Chrm5 cholinergic receptor, muscarinic 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chrm5provided by RGD
Official Full Name: cholinergic receptor, muscarinic 5provided by RGD
Primary source: RGD:620027
See related: EnsemblRapid:ENSRNOG00000006397 AllianceGenome:RGD:620027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled acetylcholine receptor activity. Involved in regulation of phosphatidylinositol dephosphorylation. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Orthologous to human CHRM5 (cholinergic receptor muscarinic 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 13.0), Spleen (RPKM 8.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (119739229..119791630, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (99284846..99337252, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (103966451..104018815, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The relative mRNA expression of M3 and M5 mAChR in bones of a rat osteoporosis model, was investigated.
Title: Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis.
This study demonistrted that Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: implications for mesolimbic dopamine transmission.
Title: Somatodendritic targeting of M5 muscarinic receptor in the rat ventral tegmental area: implications for mesolimbic dopamine transmission.
M5 receptor is the major muscarinic receptor subtype in rat adrenal medullary cells and may be involved in neuronal transmission under conditions where acetylcholine spills over the synapse
Title: Identification and role of muscarinic receptor subtypes expressed in rat adrenal medullary cells.
Expression of muscarinic receptor M1, M3, M5 subunits decreased in the flocculus after unilateral labyrinthectomy.
Title: [Expression change of Muscarinic receptor subunits in rat flocculus following unilateral labyrinthectomy].
These results provide further evidence of expression of the M(1) muscarinic receptor subtype in rat heart and show that the heart contains at least one other, albeit minor, muscarinic receptor population, most likely the M(5) muscarinic receptors
Title: The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles.
In the inflamed bladder, NO seems to be released via cholinergic stimuli through mucosal muscarinic M3/M5 receptors, presumably on urothelial cells, affecting bladder function
Title: Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat.
The m1-m5 muscarinic subtypes mapped to the following chromosomes: Chrm1, chromosome 1; Chrm2, chromosome 4; Chrm3, chromosome 17; Chrm4, chromosome 3; and Chrm5, chromosome 3.
Title: Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus.

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General gene information

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Markers

PMC61174P1 (e-PCR)
- UniSTS:273413

Chrm5 (e-PCR), detects polymorphism
- UniSTS:545912

D3Got55 (e-PCR)
- UniSTS:112615

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled acetylcholine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: muscarinic acetylcholine receptor M5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017362.5 → NP_059058.1 muscarinic acetylcholine receptor M5

See identical proteins and their annotated locations for NP_059058.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P08911

UniProtKB/TrEMBL

A6HP54

Related

ENSRNOP00000008387.4, ENSRNOT00000008387.8

Conserved Domains (2) summary

pfam00001
Location:46 → 255

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:39 → 166

7tm_4; Olfactory receptor