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    mylk2 myosin light chain kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mylk2provided by ZNC
    Official Full Name
    myosin light chain kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080616-2
    See related
    Ensembl:ENSDARG00000031698 AllianceGenome:ZFIN:ZDB-GENE-080616-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mlck2
    Summary
    Predicted to enable myosin light chain kinase activity. Predicted to be involved in cardiac muscle tissue morphogenesis; signal transduction; and striated muscle contraction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in heart. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mylk2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (32039261..32060883)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (32117891..32134352)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 6B Neighboring gene TPX2 microtubule nucleation factor Neighboring gene CD63 molecule Neighboring gene LETM1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development. Chen F, et al. Curr Mol Med, 2017. PMID 29521230, Free PMC Article
    2. Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation. Tournoij E, et al. J Thromb Haemost, 2010 Mar. PMID 20002541, Free PMC Article
    3. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. Seguchi O, et al. J Clin Invest, 2007 Oct. PMID 17885681, Free PMC Article
    4. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Zhong H, et al. Mol Biosyst, 2009 Nov. PMID 19823752, Free PMC Article
    5. PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction. Peng X, et al. Int J Mol Sci, 2021 Oct 21. PMID 34768802, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin light chain kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in striated muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain kinase 2, skeletal/cardiac muscle
    Names
    skMLCK
    skeletal muscle MLCK
    NP_001410641.1
    XP_068072872.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423712.1 → NP_001410641.1  myosin light chain kinase 2, skeletal/cardiac muscle

      Status: VALIDATED

      Source sequence(s)
      BX927210, CU469363
      Related
      ENSDARP00000115941.1, ENSDART00000133801.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      32039261..32060883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216771.1 → XP_068072872.1  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395161.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      835..14207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001110520.2: Suppressed sequence

      Description
      NM_001110520.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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