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    Hes3 hes family bHLH transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hes3provided by RGD
    Official Full Name
    hes family bHLH transcription factor 3provided by RGD
    Primary source
    RGD:621339
    See related
    EnsemblRapid:ENSRNOG00000010893 AllianceGenome:RGD:621339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 18.1), Heart (RPKM 8.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hes3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168076337..168082270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162793611..162799578, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169463196..169469795, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 7 Neighboring gene G protein-coupled receptor 153 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Sharma S, et al. Cancer Res, 2001 Sep 1. PMID 11522634
    2. Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons. Hirata H, et al. J Biol Chem, 2000 Jun 23. PMID 10858455
    3. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Sasai Y, et al. Genes Dev, 1992 Dec. PMID 1340473
    4. Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. Hirata H, et al. EMBO J, 2001 Aug 15. PMID 11500373, Free PMC Article
    5. Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. Kinameri E, et al. PLoS One, 2008. PMID 19050759, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hindbrain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within midbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oculomotor nerve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of timing of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within trochlear nerve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor HES-3
    Names
    hairy and enhancer of split 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430098.1 → NP_001417027.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q04667
      UniProtKB/TrEMBL
      A0A8I6AIT4, A6IUH8, A6IUH9

    2. NM_001430099.1 → NP_001417028.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q04667
      UniProtKB/TrEMBL
      A0A8I6AIT4, A6IUH8, A6IUH9

    3. NM_001430100.1 → NP_001417029.1  transcription factor HES-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q04667
      UniProtKB/TrEMBL
      A0A8I6AIT4, A6IUH8, A6IUH9

    4. NM_022687.3 → NP_073178.1  transcription factor HES-3

      See identical proteins and their annotated locations for NP_073178.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q04667
      UniProtKB/TrEMBL
      A0A8I6AIT4, A6IUH8, A6IUH9
      Related
      ENSRNOP00000014535.1, ENSRNOT00000014536.5
      Conserved Domains (1) summary
      cd18933
      Location:1 → 55
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168076337..168082270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764381.4 → XP_008762603.1  transcription factor HES-3 isoform X1

      Conserved Domains (1) summary
      cd18933
      Location:1 → 55
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    2. XM_017593614.3 → XP_017449103.1  transcription factor HES-3 isoform X1

      Conserved Domains (1) summary
      cd18933
      Location:1 → 55
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins

    3. XM_017593612.3 → XP_017449101.1  transcription factor HES-3 isoform X1

      Conserved Domains (1) summary
      cd18933
      Location:1 → 55
      bHLH-O_HES3; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04667.1 GenPept UniProtKB/Swiss-Prot:Q04667

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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