Romo1 reactive oxygen species modulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Romo1provided by RGD
Full Name: reactive oxygen species modulator 1provided by RGD
Primary source: RGD:1587111
See related: EnsemblRapid:ENSRNOG00000045555 AllianceGenome:RGD:1587111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; protein targeting to mitochondrion; and replicative senescence. Predicted to be located in mitochondrion. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Predicted to be active in mitochondrial inner membrane. Biomarker of ureteral obstruction. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 581.7), Muscle (RPKM 480.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (165119794..165121394)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144659709..144661310)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151688213..151689813)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the expression of ROMO1 induces ROS production and activates the TGFbeta signaling pathway. It may be concluded that ROMO1 helps to provide a molecular basis for improved clinical intervention and prognosis of patients.
Title: Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HK‑2 cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cytolysis by host of symbiont cells	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reactive oxygen species modulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.