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    Haus3 HAUS augmin-like complex, subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Haus3provided by RGD
    Official Full Name
    HAUS augmin-like complex, subunit 3provided by RGD
    Primary source
    RGD:1591723
    See related
    EnsemblRapid:ENSRNOG00000069005 AllianceGenome:RGD:1591723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in microtubule organizing center and mitotic spindle. Orthologous to human HAUS3 (HAUS augmin like complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 100.1), Spleen (RPKM 82.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Haus3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80805036..80977012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (76580549..76599542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81837772..81857458)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096643 Neighboring gene Max dimerization protein 4 Neighboring gene N-acetyltransferase 8-like Neighboring gene NELL2 interacting cell ontogeny regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Lawo S, et al. Curr Biol, 2009 May 26. PMID 19427217
    2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Uehara R, et al. Proc Natl Acad Sci U S A, 2009 Apr 28. PMID 19369198, Free PMC Article
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109412.2 → NP_001102882.1  HAUS augmin-like complex subunit 3

      See identical proteins and their annotated locations for NP_001102882.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      B1WC65, F7F7L8
      Related
      ENSRNOP00000020576.5, ENSRNOT00000020576.7
      Conserved Domains (1) summary
      pfam14932
      Location:29 → 281
      HAUS-augmin3; HAUS augmin-like complex subunit 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      80805036..80977012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273606.1 → XP_063129676.1  HAUS augmin-like complex subunit 3 isoform X5

    2. XM_063273602.1 → XP_063129672.1  HAUS augmin-like complex subunit 3 isoform X1

    3. XM_063273609.1 → XP_063129679.1  HAUS augmin-like complex subunit 3 isoform X6

      UniProtKB/TrEMBL
      F1M178

    4. XM_063273600.1 → XP_063129670.1  HAUS augmin-like complex subunit 3 isoform X1

    5. XM_063273610.1 → XP_063129680.1  HAUS augmin-like complex subunit 3 isoform X7

      UniProtKB/TrEMBL
      F1M178
      Related
      ENSRNOP00000054876.3, ENSRNOT00000058068.7

    6. XM_063273607.1 → XP_063129677.1  HAUS augmin-like complex subunit 3 isoform X6

      UniProtKB/TrEMBL
      F1M178
      Related
      ENSRNOP00000098993.1, ENSRNOT00000133007.1

    7. XM_063273603.1 → XP_063129673.1  HAUS augmin-like complex subunit 3 isoform X2

      Related
      ENSRNOP00000034638.6, ENSRNOT00000029784.9

    8. XM_063273605.1 → XP_063129675.1  HAUS augmin-like complex subunit 3 isoform X4

    9. XM_063273604.1 → XP_063129674.1  HAUS augmin-like complex subunit 3 isoform X3

    10. XM_063273601.1 → XP_063129671.1  HAUS augmin-like complex subunit 3 isoform X1

    11. XM_063273614.1 → XP_063129684.1  HAUS augmin-like complex subunit 3 isoform X10

    12. XM_063273612.1 → XP_063129682.1  HAUS augmin-like complex subunit 3 isoform X8

    13. XM_063273613.1 → XP_063129683.1  HAUS augmin-like complex subunit 3 isoform X9

    14. XM_063273615.1 → XP_063129685.1  HAUS augmin-like complex subunit 3 isoform X11

      UniProtKB/TrEMBL
      B1WC65, F7F7L8

    15. XM_063273608.1 → XP_063129678.1  HAUS augmin-like complex subunit 3 isoform X6

      UniProtKB/TrEMBL
      F1M178

    16. XM_039092838.2 → XP_038948766.1  HAUS augmin-like complex subunit 3 isoform X12

    RNA

    1. XR_010057411.1 RNA Sequence

    2. XR_010057415.1 RNA Sequence

    3. XR_010057412.1 RNA Sequence

    4. XR_010057410.1 RNA Sequence

    5. XR_010057414.1 RNA Sequence

    6. XR_010057413.1 RNA Sequence

    7. XR_010057409.1 RNA Sequence

    8. XR_010057416.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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