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    Zbtb34 zinc finger and BTB domain containing 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb34provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 34provided by RGD
    Primary source
    RGD:1596130
    See related
    EnsemblRapid:ENSRNOG00000032700 AllianceGenome:RGD:1596130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB34 (zinc finger and BTB domain containing 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 46.0), Spleen (RPKM 42.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb34 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (37101033..37123758, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16703355..16726082, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (12452705..12468487, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101525 Neighboring gene GTPase activating Rap/RanGAP domain-like 3 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene uncharacterized LOC102550017 Neighboring gene zinc finger and BTB domain containing 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399597.1 → NP_001386526.1  zinc finger and BTB domain-containing protein 34 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Conserved Domains (5) summary
      smart00355
      Location:390 → 412
      ZnF_C2H2; zinc finger
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:25 → 144
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:446 → 467
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:404 → 429
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001399598.1 → NP_001386527.1  zinc finger and BTB domain-containing protein 34 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1LW70
      Related
      ENSRNOP00000110918.1, ENSRNOT00000123861.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      37101033..37123758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106212.2 → XP_038962140.1  zinc finger and BTB domain-containing protein 34 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLG2
      Related
      ENSRNOP00000096094.1, ENSRNOT00000098831.2
      Conserved Domains (5) summary
      smart00355
      Location:388 → 410
      ZnF_C2H2; zinc finger
      sd00017
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:23 → 142
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:444 → 465
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 427
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039106211.2 → XP_038962139.1  zinc finger and BTB domain-containing protein 34 isoform X1

      Conserved Domains (5) summary
      smart00355
      Location:390 → 412
      ZnF_C2H2; zinc finger
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:25 → 144
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:446 → 467
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:404 → 429
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063284576.1 → XP_063140646.1  zinc finger and BTB domain-containing protein 34 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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