Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smg1provided by RGD
Official Full Name: SMG1, nonsense mediated mRNA decay associated PI3K related kinaseprovided by RGD
Primary source: RGD:1563508
See related: EnsemblRapid:ENSRNOG00000047386 AllianceGenome:RGD:1563508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563508
Summary: Predicted to enable diacylglycerol-dependent serine/threonine kinase activity and telomeric DNA binding activity. Predicted to be involved in several processes, including nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; phosphatidylinositol phosphate biosynthetic process; and protein phosphorylation. Predicted to be located in chromatoid body and nucleoplasm. Predicted to be active in nucleus. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 401.6), Spleen (RPKM 363.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 64

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (181876134..181977894, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (172441892..172543667, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (187781577..187882833, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.
Title: Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127140 (e-PCR)
- UniSTS:208189

RH134142 (e-PCR)
- UniSTS:217424

RH68916 (e-PCR)
- UniSTS:11623

D18377 (e-PCR)
- UniSTS:124775

AA848825 (e-PCR)
- UniSTS:260981

BE100230 (e-PCR)
- UniSTS:249788

AI236718 (e-PCR)
- UniSTS:250620

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatoid body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase SMG1

Names: SMG1 phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase

NP_001414224.1

EC 2.7.11.1

XP_038957091.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427295.1 → NP_001414224.1 serine/threonine-protein kinase SMG1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GK52

Related

ENSRNOP00000092355.1, ENSRNOT00000092467.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

181876134..181977894 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101163.2 → XP_038957091.1 serine/threonine-protein kinase SMG1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMC8

Related

ENSRNOP00000078916.1, ENSRNOT00000089399.3

Conserved Domains (4) summary

cd05170
Location:2095 → 2400

PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1

pfam02260
Location:3604 → 3633

FATC; FATC domain

pfam15785
Location:605 → 1216

SMG1; Serine/threonine-protein kinase smg-1

pfam17229
Location:6 → 114

DUF5303; Region of unknown function (DUF5303)