U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    smim1 small integral membrane protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 799079, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    smim1provided by ZNC
    Official Full Name
    small integral membrane protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081022-87
    See related
    Ensembl:ENSDARG00000075500 AllianceGenome:ZFIN:ZDB-GENE-081022-87
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:194254; si:dkey-23c22.1
    Summary
    Acts upstream of or within nucleate erythrocyte development. Predicted to be located in plasma membrane. Orthologous to human SMIM1 (small integral membrane protein 1 (Vel blood group)). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See smim1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (22341462..22343222, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (22320223..22321983, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 104 Neighboring gene leucine rich repeat containing 47 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene zgc:153631

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SMIM1 underlies the Vel blood group and influences red blood cell traits. Cvejic A, et al. Nat Genet, 2013 May. PMID 23563608, Free PMC Article
    2. BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Shi W, et al. J Immunol, 2019 Nov 1. PMID 31562209
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC194254

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleate erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    small integral membrane protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163726.2 → NP_001157198.1  small integral membrane protein 1

      See identical proteins and their annotated locations for NP_001157198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT737125
      UniProtKB/Swiss-Prot
      B3DHH5
      UniProtKB/TrEMBL
      A0A8M1NSC3
      Related
      ENSDART00000137687.3
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 71
      DUF4731; Domain of unknown function (DUF4731)

    2. NM_001202430.2 → NP_001189359.2  small integral membrane protein 1

      See identical proteins and their annotated locations for NP_001189359.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT737125
      UniProtKB/Swiss-Prot
      B3DHH5
      UniProtKB/TrEMBL
      A0A8M1NSC3
      Related
      ENSDART00000142194.2
      Conserved Domains (1) summary
      pfam15875
      Location:3 → 71
      DUF4731; Domain of unknown function (DUF4731)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      22341462..22343222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3DHH5.1 GenPept UniProtKB/Swiss-Prot:B3DHH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.