CCDS Report for Consensus CDS

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Report for CCDS33159.2 (current version)

CCDS	Status	Species	Chrom.	Gene	CCDS Release	NCBI Annotation Release	Ensembl Annotation Release	Links
33159.2	Public	Homo sapiens	2	ADGRF3	24	110	108

Public Note for CCDS 33159.2

There is only one full-length mRNA, AY358172.1, that supports this CCDS splice variant although it is different at the 3' end. The 3' end of AY358172.1 would cause it to be an NMD candidate. The 3' end is supported by BC043211.1, AK122995.1 and AY358214.1 although these have extra internal exons that are not in the RefSeq. Mouse ESTs, BB730166.1 and BB728829.1, support the 3' end. Human ESTs, BI559800.1, DC308501.1, and BX118758.1, show support for some splice sites but also include additional exons. The protein encoded by this CCDS contains intact PFAM Latrophilin/CL-1-like GPS (GPS) and the 7 transmembrane receptor (Secretin family) (7tm_2) domains. Given the current evidence at this locus, this is the best variant that can be represented; this could change with future transcript evidence. It seems that a combination of AY358172.1 5' and 3' ends and the inclusion of the extra AY140955.1 exons in the middle could also create a valid splice variant but there is not enough evidence for this at this time.

Public since: CCDS release 3, NCBI annotation release 36.2, Ensembl annotation release 41

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)

Sequence IDs included in CCDS 33159.2

Source	Nucleotide ID	Protein ID	Status in CCDS	Seq. Status
EBI	ENST00000333478.10	ENSP00000327396.6	Accepted	alive
EBI	ENST00000447444.5	ENSP00000404775.1	Accepted	alive
NCBI	NM_153835.4	NP_722577.2	Accepted	alive

RefSeq	Length	Related UniProtKB/SwissProt	Length	Identity	Gaps	Mismatches
NP_722577.2	873	Q8IZF5-2	873	100%	0	0

Chromosomal Locations for CCDS 33159.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '-' strand of Chromosome 2 (NC_000002.12)

Genome Browser links:

Chromosome	Start	Stop
2	26309086	26309107
2	26309526	26309581
2	26310043	26310105
2	26310196	26310237
2	26310692	26312074
2	26312943	26313122
2	26313377	26313573
2	26313760	26313903
2	26314414	26314623
2	26316912	26317055
2	26317496	26317562
2	26346121	26346234

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.

Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair.

Nucleotide Sequence (2622 nt):
ATGACGACCCGAAAACTGAGCGCCCACTCGGCAGCGACTCCCGGCTACAAGGCTGTGACACACAAGCACC ACACCGGCTGGGCAAGGATGGCAAAGACTGGGCTGCCCGAGAAGGGACAGAGTCAGGCTGGAGGGGAATC TGGATCTGGGCAGCTCCTGGACCAAGAGAATGGAGCAGGGGAATCAGCGCTGGTCTCCGTCTATGTACAT CTGGACTTTCCAGATAAGACCTGGCCCCCTGAACTCTCCAGGACACTGACTCTCCCTGCTGCCTCAGCTT CCTCTTCCCCAAGGCCTCTTCTCACTGGCCTCAGACTCACAACAGGTGAGTACATGAGCTGCTTCGAGGC CCAGGGCTTCAAGTGGAACCTGTATGAGGTGGTGAGGGTGCCCTTGAAGGCGACAGATGTGGCTCGACTT CCATACCAGCTGTCCATCTCCTGTGCCACCTCCCCTGGCTTCCAGCTGAGCTGCTGCATCCCCAGCACAA ACCTGGCCTACACCGCGGCCTGGAGCCCTGGAGAGGGCAGCAAAGCTTCCTCCTTCAACGAGTCAGGCTC TCAGTGCTTTGTGCTGGCTGTTCAGCGCTGCCCGATGGCTGACACCACGTACGCTTGTGACCTGCAGAGC CTGGGCCTGGCTCCACTCAGGGTCCCCATCTCCATCACCATCATCCAGGATGGAGACATCACCTGCCCTG AGGACGCCTCGGTGCTCACCTGGAATGTCACCAAGGCTGGCCACGTGGCACAGGCCCCATGTCCTGAGAG CAAGAGGGGCATAGTGAGGAGGCTCTGTGGGGCTGACGGAGTCTGGGGGCCGGTCCACAGCAGCTGCACA GATGCGAGGCTCCTGGCCTTGTTCACTAGAACCAAGCTGCTGCAGGCAGGCCAGGGCAGTCCTGCTGAGG AGGTGCCACAGATCCTGGCACAGCTGCCAGGGCAGGCGGCAGAGGCAAGTTCACCCTCCGACTTACTGAC CCTGCTGAGCACCATGAAATACGTGGCCAAGGTGGTGGCAGAGGCCAGAATACAGCTTGACCGCAGAGCC CTGAAGAATCTCCTGATTGCCACAGACAAGGTCCTAGATATGGACACCAGGTCTCTGTGGACCCTGGCCC AAGCCCGGAAGCCCTGGGCAGGCTCGACTCTCCTGCTGGCTGTGGAGACCCTGGCATGCAGCCTGTGCCC ACAGGACCACCCCTTCGCCTTCAGCTTACCCAATGTGCTGCTGCAGAGCCAGCTGTTTGGACCCACGTTT CCTGCTGACTACAGCATCTCCTTCCCTACTCGGCCCCCACTGCAGGCTCAGATTCCCAGGCACTCACTGG CCCCATTGGTCCGTAATGGAACTGAAATAAGTATTACTAGCCTGGTGCTGCGAAAACTGGACCACCTTCT GCCCTCAAACTATGGACAAGGGCTGGGGGATTCCCTCTATGCCACTCCTGGCCTGGTCCTTGTCATTTCC ATCATGGCAGGTGACCGGGCCTTCAGCCAGGGAGAGGTCATCATGGACTTTGGGAACACAGATGGTTCCC CTCACTGTGTCTTCTGGGATCACAGTCTCTTCCAGGGCAGGGGGGGTTGGTCCAAAGAAGGGTGCCAGGC ACAGGTGGCCAGTGCCAGCCCCACTGCTCAGTGCCTCTGCCAGCACCTCACTGCCTTCTCCGTCCTCATG TCCCCACACACTGTTCCGGAAGAACCCGCTCTGGCGCTGCTGACTCAAGTGGGCTTGGGAGCTTCCATAC TGGCGCTGCTTGTGTGCCTGGGTGTGTACTGGCTGGTGTGGAGAGTCGTGGTGCGGAACAAGATCTCCTA TTTCCGCCACGCCGCCCTGCTCAACATGGTGTTCTGCTTGCTGGCCGCAGACACTTGCTTCCTGGGCGCC CCATTCCTCTCTCCAGGGCCCCGAAGCCCGCTCTGCCTTGCTGCCGCCTTCCTCTGTCATTTCCTCTACC TGGCCACCTTTTTCTGGATGCTGGCGCAGGCCCTGGTGTTGGCCCACCAGCTGCTCTTTGTCTTTCACCA GCTGGCAAAGCACCGAGTTCTCCCCCTCATGGTGCTCCTGGGCTACCTGTGCCCACTGGGGTTGGCAGGT GTCACCCTGGGGCTCTACCTACCTCAAGGGCAATACCTGAGGGAGGGGGAATGCTGGTTGGATGGGAAGG GAGGGGCGTTATACACCTTCGTGGGGCCAGTGCTGGCCATCATAGGCGTGAATGGGCTGGTACTAGCCAT GGCCATGCTGAAGTTGCTGAGACCTTCGCTGTCAGAGGGACCCCCAGCAGAGAAGCGCCAAGCTCTGCTG GGGGTGATCAAAGCCCTGCTCATTCTTACACCCATCTTTGGCCTCACCTGGGGGCTGGGCCTGGCCACTC TGTTAGAGGAAGTCTCCACGGTCCCTCATTACATCTTCACCATTCTCAACACCCTCCAGGGCGTCTTCAT CCTATTGTTTGGTTGCCTCATGGACAGGAAGATACAAGAAGCTTTGCGCAAACGCTTCTGCCGCGCCCAA GCCCCCAGCTCCACCATCTCCCTGGCCACAAATGAAGGCTGCATCTTGGAACACAGCAAAGGAGGAAGCG ACACTGCCAGGAAGACAGATGCTTCAGAGTGA
Translation (873 aa):
MTTRKLSAHSAATPGYKAVTHKHHTGWARMAKTGLPEKGQSQAGGESGSGQLLDQENGAGESALVSVYVH LDFPDKTWPPELSRTLTLPAASASSSPRPLLTGLRLTTGEYMSCFEAQGFKWNLYEVVRVPLKATDVARL PYQLSISCATSPGFQLSCCIPSTNLAYTAAWSPGEGSKASSFNESGSQCFVLAVQRCPMADTTYACDLQS LGLAPLRVPISITIIQDGDITCPEDASVLTWNVTKAGHVAQAPCPESKRGIVRRLCGADGVWGPVHSSCT DARLLALFTRTKLLQAGQGSPAEEVPQILAQLPGQAAEASSPSDLLTLLSTMKYVAKVVAEARIQLDRRA LKNLLIATDKVLDMDTRSLWTLAQARKPWAGSTLLLAVETLACSLCPQDHPFAFSLPNVLLQSQLFGPTF PADYSISFPTRPPLQAQIPRHSLAPLVRNGTEISITSLVLRKLDHLLPSNYGQGLGDSLYATPGLVLVIS IMAGDRAFSQGEVIMDFGNTDGSPHCVFWDHSLFQGRGGWSKEGCQAQVASASPTAQCLCQHLTAFSVLM SPHTVPEEPALALLTQVGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGA PFLSPGPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGYLCPLGLAG VTLGLYLPQGQYLREGECWLDGKGGALYTFVGPVLAIIGVNGLVLAMAMLKLLRPSLSEGPPAEKRQALL GVIKALLILTPIFGLTWGLGLATLLEEVSTVPHYIFTILNTLQGVFILLFGCLMDRKIQEALRKRFCRAQ APSSTISLATNEGCILEHSKGGSDTARKTDASE

	Links Key
	Links to:	History report BLAST report Entrez Gene Nucleotide report Protein report
	Re-query CCDS DB by:	CCDS ID Gene ID Nucleotide ID Protein ID
	Genome Browser Links:	Ensembl Genome Browser NCBI Sequence Viewer UCSC Genome Browser VEGA Genome Browser

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