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Conserved domains on  [gi|4581713|gb|AAD24735|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Macaca ochreata]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-191 9.41e-93

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 277.93  E-value: 9.41e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00110   1 MLKIIIPTIMLIPLTWLSKNNMIWINTTTYSLLISLISLLLLNQPNDNSLNFSLLFFSDSLSTPLLILTTWLLPLMLMAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00110  81 QHHLSKEPLTRKKLYITMLILLQLFLIMTFTATELIMFYILFEATLIPTLIIITRWGNQTERLNAGLYFLFYTLVGSLPL 160

                        170       180       190
                 ....*....|....*....|....*....|.
gi 4581713   161 LIMLSHTYNDTGSLNITLLTLTDQELTTTWS 191
Cdd:MTH00110 161 LVALLYIQNNLGSLNFLLLQLWAQPLPNSWS 191
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-191 9.41e-93

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 277.93  E-value: 9.41e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00110   1 MLKIIIPTIMLIPLTWLSKNNMIWINTTTYSLLISLISLLLLNQPNDNSLNFSLLFFSDSLSTPLLILTTWLLPLMLMAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00110  81 QHHLSKEPLTRKKLYITMLILLQLFLIMTFTATELIMFYILFEATLIPTLIIITRWGNQTERLNAGLYFLFYTLVGSLPL 160

                        170       180       190
                 ....*....|....*....|....*....|.
gi 4581713   161 LIMLSHTYNDTGSLNITLLTLTDQELTTTWS 191
Cdd:MTH00110 161 LVALLYIQNNLGSLNFLLLQLWAQPLPNSWS 191
Oxidored_q5_N pfam01059
NADH-ubiquinone oxidoreductase chain 4, amino terminus;
1-109 6.45e-20

NADH-ubiquinone oxidoreductase chain 4, amino terminus;


Pssm-ID: 366442 [Multi-domain]  Cd Length: 110  Bit Score: 80.26  E-value: 6.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713      1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNH-STYLSSDPLTTPLLMLTVWLLPLMIMA 79
Cdd:pfam01059   1 MLKILLPTLMLIPLTFLSKPKWLWTTSTLYSLLLALLSLLLLNNPSNFSWSNlSYFLGIDSLSYPLIILSCWLLPLMILA 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 4581713     80 SQYHLCNEPPSQKKLFLSMMILLQITLILT 109
Cdd:pfam01059  81 SQKHLKSEPNNRQRTFIFLLILLQLFLILT 110
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 59-190 2.34e-16

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 75.89  E-value: 2.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713   59 DPLTTPLLMLTVWLLPLMIMASqyhlCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGS 138
Cdd:COG1008  81 DGISLPLVLLTALLTPLAILAS----WNEIKKRPKLYYALLLLLEAGMIGVFLALDLFLFYVFWELMLIPMYFLIGIWGG 156

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 4581713  139 qAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGSLNITLLTLTDQELTTTW 190
Cdd:COG1008 157 -ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTFDIAELAAAPLPLTA 207
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 56-190 3.03e-12

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 64.19  E-value: 3.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     56 LSSDPLTTPLLMLTVWLLPLMIMASQYHLCNEPpsqkKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITK 135
Cdd:TIGR01972  73 LGVDGISLLLVLLTALLTLLAILASWESIQKRV----KEFYALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLIGV 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4581713    136 WGSQaERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGsLNITLLTLTDQELTTTW 190
Cdd:TIGR01972 149 WGGP-NRIYAAMKFFLYTLAGSLLMLLAILGLYFLGG-GTFDLLELLNLPLPFGV 201
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-191 9.41e-93

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 277.93  E-value: 9.41e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00110   1 MLKIIIPTIMLIPLTWLSKNNMIWINTTTYSLLISLISLLLLNQPNDNSLNFSLLFFSDSLSTPLLILTTWLLPLMLMAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00110  81 QHHLSKEPLTRKKLYITMLILLQLFLIMTFTATELIMFYILFEATLIPTLIIITRWGNQTERLNAGLYFLFYTLVGSLPL 160

                        170       180       190
                 ....*....|....*....|....*....|.
gi 4581713   161 LIMLSHTYNDTGSLNITLLTLTDQELTTTWS 191
Cdd:MTH00110 161 LVALLYIQNNLGSLNFLLLQLWAQPLPNSWS 191
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-191 1.46e-68

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 215.45  E-value: 1.46e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00124   1 MLKIILPTIMLIPTTLLSKPKFLWTNTTTYSLLIALLSLQWLKPPYYPTKNLTQWLGIDQISAPLLVLSCWLLPLMILAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00124  81 QNHLQHEPLQRKRTFLTTLILLQTFLILAFSATELTLFYIMFEATLIPTLILITRWGNQPERLSAGTYFLFYTLISSLPL 160

                        170       180       190
                 ....*....|....*....|....*....|.
gi 4581713   161 LIMLSHTYNDTGSLNITLLTLTDQELTTTWS 191
Cdd:MTH00124 161 LIAILYLHNQTGTLSLPMLQLTHPTLTNSWT 191
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-191 1.11e-62

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 200.53  E-value: 1.11e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00068   1 MLKIIIPTLMLLPTTWLSPKKWLWTLTTTNSLIIAFLSLMWFNLPSETMNFTNKYFGIDQISSPLLILTCWLLPLMILAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00068  81 QNHLKNEPINRQRTYISMLIILQLTLILAFSATELILFYIFFEATLIPTLIIITRWGNQEERLNAGTYFLFYTLAGSLPL 160

                        170       180       190
                 ....*....|....*....|....*....|.
gi 4581713   161 LIMLSHTYNDTGSLNITLLTLTDQELTTTWS 191
Cdd:MTH00068 161 LIALLILQNSLGSLSLILLELMSPMQLMTYT 191
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-191 3.53e-50

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 168.21  E-value: 3.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFF-NQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMA 79
Cdd:MTH00127   1 MLKILIPTLMLIPTTWLTPAKWLWTTTLAHSLLIALASLTWLkNLSETGWSSLNLYMATDPLSTPLLVLTCWLLPLMILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    80 SQYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLP 159
Cdd:MTH00127  81 SQNHTAPEPINRQRMYITLLTSLQIFLILAFGATEIIMFYVMFEATLIPTLIIITRWGNQTERLNAGTYFLFYTLAGSLP 160

                        170       180       190
                 ....*....|....*....|....*....|..
gi 4581713   160 LLIMLSHTYNDTGSLNITLLTLTDQELTTTWS 191
Cdd:MTH00127 161 LLVALLLLQNSTGTLSMLTLQYSQPLQLSSWA 192
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-182 1.95e-43

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 150.13  E-value: 1.95e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPL-LFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMA 79
Cdd:MTH00044   1 MITLILLSLGIAITSWIVPKNKLWPISISQSSLISLLSLfLLNNHWSSSWHNLSLSLATDSLSSPLIILSCWLAPLSLLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    80 SQYHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLP 159
Cdd:MTH00044  81 SINHLSNNSPNNQRTFISLIIIILTALIITFSSLELILFYIAFETTLIPTLILITRWGAQKERIQAGLYFLFYTLFGSLP 160

                        170       180
                 ....*....|....*....|...
gi 4581713   160 LLIMLSHTYNDTGSLNITLLTLT 182
Cdd:MTH00044 161 LLISLIAIYSSSSSLSIPLSELN 183
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 3-190 4.98e-43

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 148.93  E-value: 4.98e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     3 KMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFF-NQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMASQ 81
Cdd:MTH00206   1 KILIPLIMLLLMTILSKKKWLWRSTTFFSFLIALLFLLWFkWSSEVGWSFSNLYLSYDPLSSPLVILSCWLLPLMFLASQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    82 YHLCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPLL 161
Cdd:MTH00206  81 NHMKNEPINRQRIYITLLIVLQLFLILFFSSSNLLLFYILFEASLIPTLLLITRWGNQKERLNAGYYFLFYTLIGSLPLL 160

                        170       180
                 ....*....|....*....|....*....
gi 4581713   162 IMLSHTYNDTGSLNITLLTLTDQELTTTW 190
Cdd:MTH00206 161 IALLFLQNSLGSLSLYILYFSKLTTWNNN 189
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-181 1.07e-28

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 110.63  E-value: 1.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTWLSKNntiWMNLTMHSLTISLIpLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00163   1 MLKFLFMLLFLIPLCFLKNS---WWLVQSLLFLLSFL-FMLLFSLSFYFSNISYFFGLDLLSFGLILLSFWICMLMILSS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEppSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00163  77 ESVYKKN--NYSNLFLFLILFLLIFLLLTFSSMNLLLFYIFFESSLIPTLFLILGWGYQPERLQAGIYLLFYTLFASLPL 154

                        170       180
                 ....*....|....*....|.
gi 4581713   161 LIMLSHTYNDTGSLNITLLTL 181
Cdd:MTH00163 155 LVGIFYLYNNSGSLSFFLLNF 175
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 39-179 1.06e-26

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 104.54  E-value: 1.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    39 LLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMASQYHLcnEPPSQKKLFLSMMILLQITLILTFMATELIMF 118
Cdd:MTH00150   3 LLLLYSSFSSYESLSELFSVDSMSSLLISLSLWISGLMMLASQKSV--KLRNKSSSFSLLVLLLCLILVLAFSVSSLLMF 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4581713   119 YILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGSLNITLL 179
Cdd:MTH00150  81 YFFFEASLIPTLLLILGWGYQPERLQAGMYMMLYTVGASLPLLLVILWMSSSYGSSFMLLI 141
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 26-180 1.02e-25

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 102.37  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    26 NLTMHSLTISLIPLLFFNQTNTNLLNH-STYLSSDPLTTPLLMLTVWLLPLMIMASQYHLcnEPPSQKKLFLSMMILLQI 104
Cdd:MTH00205  22 SFFSNLLLIGLFFSSFFFSNSFLMTSFiSSSFSFDSLSLPLIMLSFWISLLMVLASYKVF--KSNKNSKLFTVSVIMLLL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4581713   105 TLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGSLNITLLT 180
Cdd:MTH00205 100 ILILSFSVDNLLLFYITFEASLIPTLILILGWGYQPERLQASMYMMMYTLCASLPLLIGLFFLNSLNFSLSMFFNF 175
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-182 6.93e-24

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 97.12  E-value: 6.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     1 MLKMIIPTAMLLPTTwLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNHSTYLSSDPLTTPLLMLTVWLLPLMIMAS 80
Cdd:MTH00014   1 MLKLIMPLISLLLLP-LIKYPWSWALTFSTLLLLSLFTLLNLYPMSAPYSMFTESLSSDMLSAPLITLTLWITALMILAS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    81 QYHLCNEPPSqkKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPL 160
Cdd:MTH00014  80 FKIFQNNKAP--KTFMTNILILNLILLLTFSASNLLMFYIFFEASLIPTLFLILGWGYQPERLQASFYLMIYTVTASLPL 157

                        170       180
                 ....*....|....*....|..
gi 4581713   161 LIMLSHTYNDTGSLNITLLTLT 182
Cdd:MTH00014 158 LMSILLIFYTNNSLSMLMSSME 179
Oxidored_q5_N pfam01059
NADH-ubiquinone oxidoreductase chain 4, amino terminus;
1-109 6.45e-20

NADH-ubiquinone oxidoreductase chain 4, amino terminus;


Pssm-ID: 366442 [Multi-domain]  Cd Length: 110  Bit Score: 80.26  E-value: 6.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713      1 MLKMIIPTAMLLPTTWLSKNNTIWMNLTMHSLTISLIPLLFFNQTNTNLLNH-STYLSSDPLTTPLLMLTVWLLPLMIMA 79
Cdd:pfam01059   1 MLKILLPTLMLIPLTFLSKPKWLWTTSTLYSLLLALLSLLLLNNPSNFSWSNlSYFLGIDSLSYPLIILSCWLLPLMILA 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 4581713     80 SQYHLCNEPPSQKKLFLSMMILLQITLILT 109
Cdd:pfam01059  81 SQKHLKSEPNNRQRTFIFLLILLQLFLILT 110
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 55-180 8.28e-17

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 77.41  E-value: 8.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    55 YLSSDPLTTPLLMLTVWLLPLMIMASQyhlcNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIIT 134
Cdd:MTH00204  78 VFAVDGVSLFFILLTTLLIPICILISW----KSIKFLFKEFLLCLLFLEVLLIGVFSVLDLLLFYILFEGILIPMFLLIG 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 4581713   135 KWGSQAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGSLNITLLT 180
Cdd:MTH00204 154 IWGSREEKVRASYYFFFYTFAGSVFMLLGIFQLYSITGTTDYQILL 199
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 59-190 2.34e-16

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 75.89  E-value: 2.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713   59 DPLTTPLLMLTVWLLPLMIMASqyhlCNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGS 138
Cdd:COG1008  81 DGISLPLVLLTALLTPLAILAS----WNEIKKRPKLYYALLLLLEAGMIGVFLALDLFLFYVFWELMLIPMYFLIGIWGG 156

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 4581713  139 qAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGSLNITLLTLTDQELTTTW 190
Cdd:COG1008 157 -ERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTFDIAELAAAPLPLTA 207
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 59-179 3.89e-16

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 75.24  E-value: 3.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    59 DPLTTPLLMLTVWLLPLMIMASQyhlcNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGS 138
Cdd:PRK05846  81 DGISLLLVVLTALLTPLAVLASW----EEIKKRVKFYMAALLWLEGGVIGVFAALDLLLFYVFFEAMLIPMYFLIGVWGG 156

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 4581713   139 qAERLNASTYFLFYTLAGSLPLLI----MLSHTYNDTGSLNITLL 179
Cdd:PRK05846 157 -KNRIYAATKFFLYTLLGSLLMLVaiiyLVVVYYNATGTFDIADL 200
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 66-173 1.92e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 70.47  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    66 LMLTVWLLPLMIMASQyhlcNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNA 145
Cdd:MTH00217  86 LILTALLTPICILISW----NSIKFLIKEFLLCLLVIEILLMGVFTILDLVGFYILFEGILIPMFLIIGIWGSREEKVQA 161

                         90       100
                 ....*....|....*....|....*...
gi 4581713   146 STYFLFYTLAGSLPLLIMLSHTYNDTGS 173
Cdd:MTH00217 162 SYYFFFYTFIGSVFMLLGIFTLYSYAGT 189
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 59-173 3.68e-13

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 66.87  E-value: 3.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    59 DPLTTPLLMLTVWLLPLMIMASQyhlcNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGS 138
Cdd:MTH00226 101 DGISIYFIILTGFIVPCSILISW----HSVKYLTKSFLICMLILEFLLYAVFSVLDIFMFYILFEGVLIPMYLILGIWGS 176

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 4581713   139 QAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGS 173
Cdd:MTH00226 177 REEKMQAAYYFFFYTLIGSVLMLLCLFSLYNIHGT 211
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 56-190 3.03e-12

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 64.19  E-value: 3.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713     56 LSSDPLTTPLLMLTVWLLPLMIMASQYHLCNEPpsqkKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITK 135
Cdd:TIGR01972  73 LGVDGISLLLVLLTALLTLLAILASWESIQKRV----KEFYALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLIGV 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4581713    136 WGSQaERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGsLNITLLTLTDQELTTTW 190
Cdd:TIGR01972 149 WGGP-NRIYAAMKFFLYTLAGSLLMLLAILGLYFLGG-GTFDLLELLNLPLPFGV 201
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 56-187 3.73e-11

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 60.82  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    56 LSSDPLTTPLLMLTVWLLPLMIMASqYHLCNEPpsqkKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITK 135
Cdd:PRK12561  55 LGVDGLSMPLVLLSGLITTLSIFAS-WKVTRKP----RLFYFLMLVLYSAQIGVFLAQDLLLFFLMWELELVPVYLLISI 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4581713   136 WGSQaERLNASTYFLFYTLAGSLPLLI--MLSHTYNDTGSLNITLLTLTDQELT 187
Cdd:PRK12561 130 WGGQ-KRLYAATKFILYTALASIFILVagLALALSGDTFTFDLAELGAKSYPLA 182
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 112-183 1.32e-08

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 53.09  E-value: 1.32e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4581713    112 ATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGSLNITLLTLTD 183
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKAL 72
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 94-168 7.13e-08

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 51.06  E-value: 7.13e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4581713    94 LFLSMMILLQItlILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPLLIMLSHTY 168
Cdd:MTH00094  65 LILSNLLILIC--LLFFVSSNMLMLYMFFELSMFPILIMILGYGSQIEKINSSYYLLFYAAFFSFPFLFVYLKNF 137
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 58-183 1.40e-06

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 47.39  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    58 SDPLTTPLLMLTVWLLPLMIMASQyhlcnePPSQK-KLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKW 136
Cdd:PRK02546  85 ADGLSMPLILLTGFITTLAVLAAW------PVTFKpKLFYFLMLAMYGGQIAVFAVQDMLLFFLAWELELIPVYLLLAIW 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 4581713   137 GSQaERLNASTYFLFYTLAGSLPLLI--MLSHTYNDTGSLNITLLTLTD 183
Cdd:PRK02546 159 GGK-KRQYAATKFILYTAGSSLFILLaaLAMAFYGDTPTFDMTALAAKD 206
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
53-153 2.45e-05

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 43.92  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    53 STYLSSDPLTTPLLMLTVWLLPLMIMASqyhlcNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLII 132
Cdd:PRK06473  72 SYHLGVDGLSLPLLVLNSLLTLIAIYSS-----DESIQRPRFYYSLLLLLNAGVSGAFLAQDLLLFFLFYELELIPLYLL 146

                         90       100
                 ....*....|....*....|.
gi 4581713   133 ITKWGSQaERLNASTYFLFYT 153
Cdd:PRK06473 147 IAIWGGQ-RRGYAATKFLLYT 166
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
56-153 1.01e-04

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 42.01  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    56 LSSDPLTTPLLMLTVWLLPLMIMASqyhlcNEPPSQKKLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITK 135
Cdd:PRK07363  75 LGVDGLSLPLLVLNSLLTWIAIYSI-----GENTERPRLYYSLILLINGGIAGALLAQNLLLFFLFYELELIPFYLLIAI 149

                         90
                 ....*....|....*...
gi 4581713   136 WGSQaERLNASTYFLFYT 153
Cdd:PRK07363 150 WGGE-KRGYASIKFLIYT 166
ndhD CHL00011
NADH dehydrogenase subunit 4
 93-162 2.74e-04

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 40.70  E-value: 2.74e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    93 KLFLSMMILLQITLILTFMATELIMFYILFETTLIPTLIIITKWGSQaERLNASTYFLFYTLAGSLPLLI 162
Cdd:CHL00011 112 RLFYFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGK-KRLYSATKFILYTAGGSIFLLI 180
ND4 MTH00062
NADH dehydrogenase subunit 4; Provisional
 94-176 7.33e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214413 [Multi-domain]  Cd Length: 417  Bit Score: 39.52  E-value: 7.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4581713    94 LFLSMmillqITLILTFMATELIMFYILFETTLIPTLIIITKWGSQAERLNASTYFLFYTLAGSLPLLIMLSHTYNDTGS 173
Cdd:MTH00062  77 LFLSL-----IFSILCFCVNNSLLFWFFYELSIIPLLYLLFSESPYSERYLASWYFLGYLLLTSLPLLLCLLYLSLVNGS 151


                 ...
gi 4581713   174 LNI 176
Cdd:MTH00062 152 FNF 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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