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Conserved domains on  [gi|6560599|gb|AAF16677|]
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small solute channel 1 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-267 3.20e-75

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 229.63  E-value: 3.20e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   21 SLAKETLSEFLGTFILIVLGCGCVAQAILSRGrFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  101 KLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGkllivgeNATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF 180
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGIT 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  181 DSRNlgAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGfevfrAGNNFWWIPVVGPLVGAVIGGL 260
Cdd:COG0580 153 DKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGG-----SDWGYLWVPIVAPILGAALAAL 225


                ....*..
gi 6560599  261 IYVLVIE 267
Cdd:COG0580 226 LYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-267 3.20e-75

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 229.63  E-value: 3.20e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   21 SLAKETLSEFLGTFILIVLGCGCVAQAILSRGrFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  101 KLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGkllivgeNATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF 180
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGIT 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  181 DSRNlgAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGfevfrAGNNFWWIPVVGPLVGAVIGGL 260
Cdd:COG0580 153 DKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGG-----SDWGYLWVPIVAPILGAALAAL 225


                ....*..
gi 6560599  261 IYVLVIE 267
Cdd:COG0580 226 LYRALFG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 1-266 3.40e-73

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 226.55  E-value: 3.40e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     1 MQPEGAEKGK------SFKQRLVLKSSLaKETLSEFLGTFILIVLGCGCVAQAILSrGRFGGVITINVGFSMAVAMAIYV 74
Cdd:PTZ00016  23 MDEEVAEAQKrppggqNFWAPREYRPNV-REYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    75 AGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDgLMSFAGGKLLI--VGENATAHIFATYP 152
Cdd:PTZ00016 101 SAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYG-FFKDHGIPELPweTMANGFAGVFATYP 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   153 ApyLSLANAFADQVVATMILLIIVFAIFDSRNLGApRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAgW 232
Cdd:PTZ00016 180 R--EGNFYAIFSELILTAILLLVILAITDPNNCPA-FNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-W 255

                        250       260       270
                 ....*....|....*....|....*....|....
gi 6560599   233 GFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVI 266
Cdd:PTZ00016 256 GSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFI 289
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 24-265 3.77e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.05  E-value: 3.77e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   24 KETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  104 FYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGenatahIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSR 183
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG------IFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  184 NLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAgwgfevfrAGNNFWWIPVVGPLVGAVIGGLIYV 263
Cdd:cd00333 155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226


                ..
gi 6560599  264 LV 265
Cdd:cd00333 227 YV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 28-262 9.76e-55

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 176.72  E-value: 9.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     28 SEFLGTFILIVLGCGCVAQAILSRGR----FGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    104 FYVGAQFLGAFVGAATVFGIYYDGlmsfAGGKLLIVGEnatahifatyPAPYLSLANAFADQVVATMILLIIVFAIFDSR 183
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGL----FPGNLAVNGS----------ASAGVSSGQAFFVEFIGTAILVLVIFATTDDR 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6560599    184 NLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWgfevfragnNFWWIPVVGPLVGAVIGGLIY 262
Cdd:TIGR00861 147 NRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGW---------GNHWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 19-262 3.09e-46

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 155.17  E-value: 3.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     19 KSSLAKETLSEFLGTFILIVLGCGCVA--QAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGR 96
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALgvKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     97 MKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMsfaggkllivgenatAHIFATYPAPYLSLANAFADQVVATMILLIIV 176
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQR---------------AGLFANTLAPGVNAGQAFVVEIILTFQLVYCV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    177 FAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTalagWGFEVFragnnfwWIPVVGPLVGAV 256
Cdd:pfam00230 149 FATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----WKWDDH-------WVYWVGPFIGAA 217


                  ....*.
gi 6560599    257 IGGLIY 262
Cdd:pfam00230 218 LGALVY 223
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-267 3.20e-75

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 229.63  E-value: 3.20e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   21 SLAKETLSEFLGTFILIVLGCGCVAQAILSRGrFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  101 KLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGkllivgeNATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF 180
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDG-------GAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGIT 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  181 DSRNlgAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGfevfrAGNNFWWIPVVGPLVGAVIGGL 260
Cdd:COG0580 153 DKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKGG-----SDWGYLWVPIVAPILGAALAAL 225


                ....*..
gi 6560599  261 IYVLVIE 267
Cdd:COG0580 226 LYRALFG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 1-266 3.40e-73

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 226.55  E-value: 3.40e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     1 MQPEGAEKGK------SFKQRLVLKSSLaKETLSEFLGTFILIVLGCGCVAQAILSrGRFGGVITINVGFSMAVAMAIYV 74
Cdd:PTZ00016  23 MDEEVAEAQKrppggqNFWAPREYRPNV-REYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    75 AGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDgLMSFAGGKLLI--VGENATAHIFATYP 152
Cdd:PTZ00016 101 SAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYG-FFKDHGIPELPweTMANGFAGVFATYP 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   153 ApyLSLANAFADQVVATMILLIIVFAIFDSRNLGApRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAgW 232
Cdd:PTZ00016 180 R--EGNFYAIFSELILTAILLLVILAITDPNNCPA-FNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-W 255

                        250       260       270
                 ....*....|....*....|....*....|....
gi 6560599   233 GFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVI 266
Cdd:PTZ00016 256 GSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFI 289
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 24-265 3.77e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.05  E-value: 3.77e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   24 KETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  104 FYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGenatahIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSR 183
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAG------IFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599  184 NLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAgwgfevfrAGNNFWWIPVVGPLVGAVIGGLIYV 263
Cdd:cd00333 155 NGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA--------RHWHYFWVYWVGPLIGAIAGALVYD 226


                ..
gi 6560599  264 LV 265
Cdd:cd00333 227 YV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 28-262 9.76e-55

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 176.72  E-value: 9.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     28 SEFLGTFILIVLGCGCVAQAILSRGR----FGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLP 103
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgavgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    104 FYVGAQFLGAFVGAATVFGIYYDGlmsfAGGKLLIVGEnatahifatyPAPYLSLANAFADQVVATMILLIIVFAIFDSR 183
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGL----FPGNLAVNGS----------ASAGVSSGQAFFVEFIGTAILVLVIFATTDDR 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6560599    184 NLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWgfevfragnNFWWIPVVGPLVGAVIGGLIY 262
Cdd:TIGR00861 147 NRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGW---------GNHWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 19-262 3.09e-46

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 155.17  E-value: 3.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     19 KSSLAKETLSEFLGTFILIVLGCGCVA--QAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGR 96
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALgvKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599     97 MKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMsfaggkllivgenatAHIFATYPAPYLSLANAFADQVVATMILLIIV 176
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQR---------------AGLFANTLAPGVNAGQAFVVEIILTFQLVYCV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    177 FAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTalagWGFEVFragnnfwWIPVVGPLVGAV 256
Cdd:pfam00230 149 FATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----WKWDDH-------WVYWVGPFIGAA 217


                  ....*.
gi 6560599    257 IGGLIY 262
Cdd:pfam00230 218 LGALVY 223
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 23-271 1.02e-26

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 105.71  E-value: 1.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    23 AKETLSEFLGTFILIVLGCGCVAQAILSRGRFGgVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKL 102
Cdd:PLN00183  45 ARMVLAEMVGTFILMFCVCGIIASTQLSGGEVG-LLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKV 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   103 PFYVGAQFLGAFvgAATVFGIYYDGLmsfaggkllivgenaTAHIFATYPApyLSLANAFADQVVATMILLIIVFAI-FD 181
Cdd:PLN00183 124 PLYITAQTVGSV--LATYVGVSVYGV---------------KADLMTTKPA--QGCSSAFWVEFIATFIVMFLAASLtSQ 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   182 SRNLGAPRG-LEPIAIGLLIIVIasslGLNSGCAMNPARDLSPrlftALAGWGFEVFragnnfwWIPVVGPLVGAVIGGL 260
Cdd:PLN00183 185 PQSLGHLSGfVIGIAIGLAVLIT----GPVSGGSMNPARSLGP----AIVSWDFKDI-------WIYITAPTIGAVAGAL 249

                        250
                 ....*....|.
gi 6560599   261 IYVLVIEIHHP 271
Cdd:PLN00183 250 MFHLLRLRTQP 260
PRK05420 PRK05420
aquaporin Z; Provisional
 22-267 8.54e-26

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 101.97  E-value: 8.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    22 LAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFK 101
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFGGCGSAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   102 LPFYVGAQFLGAFVGAATVFGIyydglmsfAGGKlliVGENATAHIFAT------YPAPYlSLANAFADQVVATMILLII 175
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYLI--------ASGK---AGFDLAGSGFASngygehSPGGY-SLLAALVCEVVLTAFFLLV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   176 VFAIFDSRnlgAPRGLEPIAIGL---LIIVIASSLglnSGCAMNPARDLSPRLFtaLAGWGFEVFragnnfwWIPVVGPL 252
Cdd:PRK05420 149 ILGATDKR---APAGFAPIAIGLaltLIHLISIPV---TNTSVNPARSTGVALF--VGGWALEQL-------WLFWVAPI 213

                        250
                 ....*....|....*
gi 6560599   253 VGAVIGGLIYVLVIE 267
Cdd:PRK05420 214 VGAIIGGLIYRLLLE 228
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 22-265 6.68e-25

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 100.75  E-value: 6.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    22 LAKETLSEFLGTFILIVLGCGCVAQAILsrgrFGGVIT---INVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMK 98
Cdd:PLN00182  41 LTQKLIAEMIGTYFIIFSGCGVVVVNVL----YGGTITfpgICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFP 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    99 WFKLPFYVGAQFLGAFVgaatvfgiyydglmsfAGGKLLIVGENATAHIFATYPAPylSLANAFADQVVATMILLIIVFA 178
Cdd:PLN00182 117 WYQVPLYIGAQLTGSLL----------------ASLTLRLMFNVTPEAFFGTTPTD--SSGQALVAEIIISFLLMFVISG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   179 I-FDSRNLGAPRGlepIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTAlagwgfeVFRAgnnfWWIPVVGPLVGAVI 257
Cdd:PLN00182 179 VaTDSRAVGELAG---IAVGMTIILNVFVAGPISGASMNPARSLGPAIVMG-------RYKG----IWVYIVGPFVGIIA 244


                 ....*...
gi 6560599   258 GGLIYVLV 265
Cdd:PLN00182 245 GGFVYNLI 252
PLN00026 PLN00026
aquaporin NIP; Provisional
 21-265 1.92e-21

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 91.85  E-value: 1.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    21 SLAKETLSEFLGTFILIVLGcgcVAQAILSRgRFGGVITInVGFS----MAVAMAIYVAGGVSGGHINPAVSLAMCLFGR 96
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAA---TAGPIVNQ-KYDGAETL-IGNAacagLAVMIVILSTGHISGAHLNPSLTIAFAALRH 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    97 MKWFKLPFYVGAQFLGAFVGAATVFGIYYdglmSFAGGKLLIvgenatahifatypaPYLSLANAFADQVVATMILLIIV 176
Cdd:PLN00026 144 FPWKHVPAYIAAQVSASICASFALKGVFH----PFMSGGVTV---------------PSVSTGQAFALEFIITFNLLFVV 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   177 FAI-FDSRNLGAPRGLEPIAIGLLIIVIAsslGLNSGCAMNPARDLSPRLftalagwgfevfrAGNNF--WWIPVVGPLV 253
Cdd:PLN00026 205 TAVaTDTRAVGELAGIAVGATVMLNILVA---GPSTGGSMNPVRTLGPAV-------------AAGNYraIWIYLVAPTL 268

                        250
                 ....*....|..
gi 6560599   254 GAVIGGLIYVLV 265
Cdd:PLN00026 269 GALAGAGTYTAV 280
PLN00184 PLN00184
aquaporin NIP1; Provisional
 24-265 1.22e-19

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 86.61  E-value: 1.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    24 KETLSEFLGTFILIVLGCGCVAQAIlsrgRFGGVIT---INVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWF 100
Cdd:PLN00184  55 QKLIAEVLGTYFLVFTGCASVVVNM----QNDNVVTlpgIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   101 KLPFYVGAQFLGAFVGAAT---VFGIYYDglmsFAGGKllivgenataHIFATYPAPYLSLANAFADQVVATMILLIIVF 177
Cdd:PLN00184 131 QVPAYVISQVIGSTLAAATlrlLFGLDHD----VCSGK----------HDVFIGSSPVGSDLQAFVMEFIVTFYLMFIIS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   178 AI-FDSRNLGAPRGLEPIAIGLLIIVIASSLglnSGCAMNPARDLSPRLFtalagwgFEVFRAgnnfWWIPVVGPLVGAV 256
Cdd:PLN00184 197 GVaTDNRAIGELAGLAIGSTVLLNVLIAAPV---SSASMNPGRSLGPAMV-------YGCYKG----IWIYIVAPTLGAI 262


                 ....*....
gi 6560599   257 IGGLIYVLV 265
Cdd:PLN00184 263 AGAWVYNTV 271
PLN00166 PLN00166
aquaporin TIP2; Provisional
 24-262 3.55e-14

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 70.74  E-value: 3.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    24 KETLSEFLGTFILIVLGCG-CVAQAILSRGRF---GGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKW 99
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGsAIAFAKLTSDAAldpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   100 FKLPFYVGAQFLGAFVGAAtvfgiyydgLMSFAGGkllivGENATAHIFATypapYLSLANAFADQVVATMILLIIVFAI 179
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACL---------LLVFVTN-----GESVPTHGVAA----GLGAIEGVVMEIVVTFALVYTVYAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   180 FDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPrlftalagwgfEVFRAGNNFWWIPVVGPLVGAVIGG 259
Cdd:PLN00166 161 AADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGP-----------AVVSGDFSQIWIYWVGPLVGGALAG 229


                 ...
gi 6560599   260 LIY 262
Cdd:PLN00166 230 LIY 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 23-273 6.74e-13

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 67.12  E-value: 6.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    23 AKETLSEFLGTFILIVLGCGC-VAQAILSRGRF---GGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMK 98
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSgMAFNKLTDNGSttpAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    99 WFKLPFYVGAQFLGAFVGAAtvfgiyydgLMSFAGGKLlivgenaTAHIFATYPApyLSLANAFADQVVATMILLIIVFA 178
Cdd:PLN00027 100 LLRGILYWIAQLLGSVVACL---------LLKFSTGGL-------ETSAFSLSSG--VGVWNAFVFEIVMTFGLVYTVYA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   179 IFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPrlftALAGWGFEVFragnnfwWIPVVGPLVGAVIG 258
Cdd:PLN00027 162 TAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGP----AVVSWTWTNH-------WVYWAGPLIGGGIA 230

                        250
                 ....*....|....*.
gi 6560599   259 GLIY-VLVIEIHHPEP 273
Cdd:PLN00027 231 GLVYeLIFIGSTTHEQ 246
PLN00167 PLN00167
aquaporin TIP5; Provisional
 27-262 1.38e-11

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 63.38  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599    27 LSEFLGTFILI--VLGCGCVAQAILSRGRFG--GVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKL 102
Cdd:PLN00167  26 LAEFISTFFFVfaAVGSAMSSRKLMPDAASDpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   103 PFYVGAQFLGAfvgaatvfgiyydgLMSFAGGKLLIVGENATAHIFATYPAPYlslaNAFADQVVATMILLIIVFAIFDS 182
Cdd:PLN00167 106 MFYWISQMLAS--------------VMACLFLKVTTVGQHVPTYKIAEEMTGF----GASVLEGVLTFGLVYTVYAAGDP 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6560599   183 RNlGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSprlfTALAGWGFEvfraGNNFWWipvVGPLVGAVIGGLIY 262
Cdd:PLN00167 168 RR-GLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFG----SAVVAGSFK----NQAVYW---VGPLLGGAVAGLLY 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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