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Conserved domains on  [gi|13097417|gb|AAH03447|]
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FK506 binding protein 4 [Mus musculus]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 10446594)

FKBP-type peptidyl-prolyl cis-trans isomerase acts as a PPIase that accelerates the folding of proteins

CATH:  3.10.50.40
EC:  5.2.1.8
Gene Ontology:  GO:0003755|GO:0000413|GO:0061077
PubMed:  27664121
SCOP:  4001062

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 9.66e-44

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.50  E-value: 9.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417    43 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 13097417   122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
215-424 6.34e-18

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 82.27  E-value: 6.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 215 EHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEmSSAEKLEQSNIVKERGTAYFKEGKYKQALlqyk 294
Cdd:COG4785  19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERID-RALALPDLAQLYYERGVAYDSLGDYDLAI---- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 295 kivswleyeSSFSgeemqkvRALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 369
Cdd:COG4785  94 ---------ADFD-------QALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13097417 370 DLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 424
Cdd:COG4785 158 ELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 9.66e-44

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.50  E-value: 9.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417    43 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 13097417   122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 35-134 2.83e-42

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 144.94  E-value: 2.83e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417  35 KVIKrEGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYG 114
Cdd:COG0545   4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                        90       100
                ....*....|....*....|
gi 13097417 115 AAGSPPKIPPNATLVFEVEL 134
Cdd:COG0545  82 ERGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 28-138 2.75e-19

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 87.51  E-value: 2.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   28 KQDEGVLKVIKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITC 107
Cdd:PRK10902 143 TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVI 219

                         90       100       110
                 ....*....|....*....|....*....|.
gi 13097417  108 KPEYAYGAAGSpPKIPPNATLVFEVELFEFK 138
Cdd:PRK10902 220 PPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
215-424 6.34e-18

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 82.27  E-value: 6.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 215 EHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEmSSAEKLEQSNIVKERGTAYFKEGKYKQALlqyk 294
Cdd:COG4785  19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERID-RALALPDLAQLYYERGVAYDSLGDYDLAI---- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 295 kivswleyeSSFSgeemqkvRALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 369
Cdd:COG4785  94 ---------ADFD-------QALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13097417 370 DLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 424
Cdd:COG4785 158 ELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-395 1.07e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   236 QIPPHAELRY-----EVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEyessfsgee 310
Cdd:TIGR02917 256 KAPNSPLAHYlkalvDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP--------- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   311 mQKVRALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:TIGR02917 327 -NSHQARRL-----LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAAR 400


                  ....*
gi 13097417   391 TQLAV 395
Cdd:TIGR02917 401 TQLGI 405
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 323-390 2.20e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.16  E-value: 2.20e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13097417 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:cd24142   4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
TPR_1 pfam00515
Tetratricopeptide repeat;
321-352 4.56e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.48  E-value: 4.56e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 13097417   321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-439 8.32e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 44.78  E-value: 8.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417  326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 405
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13097417  406 REKKLYANMFERLAEEE-----HKVKAEVAAGDHPTDAE 439
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEE 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 322-352 8.49e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 8.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 13097417    322 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-134 9.66e-44

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.50  E-value: 9.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417    43 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 13097417   122 IPPNATLVFEVEL 134
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 35-134 2.83e-42

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 144.94  E-value: 2.83e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417  35 KVIKrEGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYG 114
Cdd:COG0545   4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                        90       100
                ....*....|....*....|
gi 13097417 115 AAGSPPKIPPNATLVFEVEL 134
Cdd:COG0545  82 ERGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 28-138 2.75e-19

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 87.51  E-value: 2.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   28 KQDEGVLKVIKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITC 107
Cdd:PRK10902 143 TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG--VIPGWTEGLKNIKKGGKIKLVI 219

                         90       100       110
                 ....*....|....*....|....*....|.
gi 13097417  108 KPEYAYGAAGSpPKIPPNATLVFEVELFEFK 138
Cdd:PRK10902 220 PPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
215-424 6.34e-18

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 82.27  E-value: 6.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 215 EHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEmSSAEKLEQSNIVKERGTAYFKEGKYKQALlqyk 294
Cdd:COG4785  19 ASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERID-RALALPDLAQLYYERGVAYDSLGDYDLAI---- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 295 kivswleyeSSFSgeemqkvRALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 369
Cdd:COG4785  94 ---------ADFD-------QALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13097417 370 DLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 424
Cdd:COG4785 158 ELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 47-136 1.31e-16

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 78.30  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   47 PMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSPPKIPPNA 126
Cdd:PRK11570 117 PARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFS 194

                         90
                 ....*....|
gi 13097417  127 TLVFEVELFE 136
Cdd:PRK11570 195 TLVFEVELLE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
248-458 1.52e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 248 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvrALRL-----ASH 322
Cdd:COG0457  20 RLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQ--------------------ALELdpddaEAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC---QQR 399
Cdd:COG0457  80 NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAlekLGR 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13097417 400 TRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSRVETEA 458
Cdd:COG0457 160 YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAA 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
276-402 2.43e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 2.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 276 RGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvrALRLA-----SHLNLAMCHLKLQAFSAAIESCNKALELDS 350
Cdd:COG0457  14 LGLAYRRLGRYEEAIEDYEK--------------------ALELDpddaeALYNLGLAYLRLGRYEEALADYEQALELDP 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 13097417 351 NNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG0457  74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 236-400 4.90e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 4.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 236 QIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIvswLEYESSFsgeemqkvr 315
Cdd:COG3914  78 AALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRA---LALNPDF--------- 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 316 alrLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:COG3914 146 ---AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222


                ....*
gi 13097417 396 CQQRT 400
Cdd:COG3914 223 ALRQA 227
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 267-402 2.12e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 2.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 267 LEQSNIVKERGTAYFKEGKYKQALLQYKKivsWLEYESSFsgeemqkvralrLASHLNLAMCHLKLQAFSAAIESCNKAL 346
Cdd:COG3914  75 LLLAALLELAALLLQALGRYEEALALYRR---ALALNPDN------------AEALFNLGNLLLALGRLEEALAALRRAL 139

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13097417 347 ELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG3914 140 ALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 248-453 3.39e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 3.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 248 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvralrlasHLNLAM 327
Cdd:COG2956  88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA---------------YCELAE 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 328 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 407
Cdd:COG2956 153 LYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEAL 232

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 13097417 408 KKLyanmfERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSR 453
Cdd:COG2956 233 ELL-----RKALELDPSDDLLLALADLLERKEGLEAALALLERQLR 273
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 50-145 9.72e-11

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 59.34  E-value: 9.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417  50 GDRVFVHYTGWLLDGTKFDSSLDRkDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGaagsppkiPPNATLV 129
Cdd:COG1047   4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                        90
                ....*....|....*.
gi 13097417 130 FEVELFEFKGEDLTEE 145
Cdd:COG1047  75 QTVPREQFPEDEELEV 90
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
321-402 1.98e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 1.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRT 400
Cdd:COG0457  10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89


                ..
gi 13097417 401 RR 402
Cdd:COG0457  90 GR 91
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 279-390 2.03e-10

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 57.69  E-value: 2.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 279 AYFKEGKYKQALLQYKKIVSwlEYESSfsgeemqkvrALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK---G 355
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLK--RYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdA 69

                        90       100       110
                ....*....|....*....|....*....|....*
gi 13097417 356 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:COG1729  70 LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAK 104
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 322-407 4.61e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 4.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 322 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC-QQRT 400
Cdd:COG4235  20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99


                ....*..
gi 13097417 401 RRQLARE 407
Cdd:COG4235 100 DYAEAIA 106
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 277-389 5.49e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 5.49e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 277 GTAYFKEGKYKQALLQYKkivswleyessfsgeemqkvRALRLAS-----HLNLAMCHLKLQAFSAAIESCNKALELDSN 351
Cdd:COG4235  24 GRAYLRLGRYDEALAAYE--------------------KALRLDPdnadaLLDLAEALLAAGDTEEAEELLERALALDPD 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 13097417 352 NEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAA 389
Cdd:COG4235  84 NPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 275-402 7.56e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 7.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 275 ERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVRALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEAL---------------ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 13097417 355 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG2956  78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 248-420 2.10e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 2.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 248 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSwleyessfsgEEMQKVRALRLashlnLAM 327
Cdd:COG2956  54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE----------LDPDDAEALRL-----LAE 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 328 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTR------ 401
Cdd:COG2956 119 IYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGdyeeai 198

                       170       180
                ....*....|....*....|..
gi 13097417 402 ---RQLAREKKLYANMFERLAE 420
Cdd:COG2956 199 aalERALEQDPDYLPALPRLAE 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 276-386 4.45e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 4.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 276 RGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVRALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 355
Cdd:COG4783  44 LGEILLQLGDLDEAIVLLHEAL---------------ELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                        90       100       110
                ....*....|....*....|....*....|.
gi 13097417 356 LFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:COG4783 109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-395 1.07e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   236 QIPPHAELRY-----EVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEyessfsgee 310
Cdd:TIGR02917 256 KAPNSPLAHYlkalvDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP--------- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   311 mQKVRALRLashlnLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:TIGR02917 327 -NSHQARRL-----LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAAR 400


                  ....*
gi 13097417   391 TQLAV 395
Cdd:TIGR02917 401 TQLGI 405
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 314-410 2.04e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.43  E-value: 2.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 314 VRALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQL 393
Cdd:COG5010  49 KLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNL 128

                        90
                ....*....|....*..
gi 13097417 394 AVCQQRTRRQLAREKKL 410
Cdd:COG5010 129 AALLLSLGQDDEAKAAL 145
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
279-385 3.29e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.94  E-value: 3.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 279 AYFKEGKYKQALLQYKKIVswleyessfsgeemqKVRALRLASHLNLAMCHLKLQAFSAAIEsCNKALELDSNNEKGLFR 358
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKAL---------------ELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN 64

                        90       100
                ....*....|....*....|....*..
gi 13097417 359 RGEAHLAVNDFDLARADFQKVLQLYPS 385
Cdd:COG3063  65 LAELLLELGDYDEALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 275-410 3.86e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 3.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 275 ERGTAYFKEGKYKQALLQYKKIVSwleyessfsgEEMQKVRALrlashLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 354
Cdd:COG4783   9 ALAQALLLAGDYDEAEALLEKALE----------LDPDNPEAF-----ALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13097417 355 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKL 410
Cdd:COG4783  74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 337-394 1.64e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 1.64e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13097417 337 AAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLA 394
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA 58
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 241-384 1.69e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 241 AELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvralrla 320
Cdd:COG5010  25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL-------------- 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13097417 321 sHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYP 384
Cdd:COG5010  91 -YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 241-399 5.63e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 51.91  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   241 AELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVRALRLA 320
Cdd:TIGR00990 284 NELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDPR 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   321 ---SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQ 397
Cdd:TIGR00990 364 vtqSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQ 443


                  ..
gi 13097417   398 QR 399
Cdd:TIGR00990 444 YK 445
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 307-439 1.50e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.85  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   307 SGEEMQKVRALrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:TIGR02917 456 KLEKKQPDNAS---LHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN 532

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 13097417   387 KAAKTQLAVCQQRTRRqlarekklyanmferlaEEEHKVKAEVAAGDHPTDAE 439
Cdd:TIGR02917 533 LRAILALAGLYLRTGN-----------------EEEAVAWLEKAAELNPQEIE 568
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 316-402 2.07e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.11  E-value: 2.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80


                ....*..
gi 13097417 396 CQQRTRR 402
Cdd:COG4783  81 ALLKAGD 87
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 323-390 2.20e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.16  E-value: 2.20e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13097417 323 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 390
Cdd:cd24142   4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
328-402 3.81e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 3.81e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13097417 328 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARAdFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGD 74
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 251-406 2.18e-05

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 45.64  E-value: 2.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 251 SFEKAKESWemsSAEKLeqsnivKERGTAYFKEGKYKQALLQYKKIVSWLEYessfsGEEMQKVRalrlashLNLAMCHL 330
Cdd:COG4105  22 SFKKALKSW---DAEEL------YEEAKEALEKGDYEKAIKLFEELEPRYPG-----SPYAEQAQ-------LMLAYAYY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 331 KLQAFSAAIESCNKALELDSNNEK---GLFRRGEAH-LAVNDFDL-------ARADFQKVLQLYP-SNKAAKtqlavCQQ 398
Cdd:COG4105  81 KQGDYEEAIAAADRFIKLYPNSPNadyAYYLRGLSYyEQSPDSDRdqtstrkAIEAFQELINRYPdSEYAED-----AKK 155

                       170
                ....*....|.
gi 13097417 399 R---TRRQLAR 406
Cdd:COG4105 156 RideLRDKLAR 166
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
264-419 3.71e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 45.26  E-value: 3.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 264 AEKLEQSNIVKER---GTAYFKEGKYKQALLQYkkivswleyESSFSGEEMQKVRALrlashLNLAMCHLKLQAFSAAIE 340
Cdd:COG4700  80 EKALEFADTVQNRvrlADALLELGRYDEAIELY---------EEALTGIFADDPHIL-----LGLAQALFELGRYAEALE 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 341 SCNKALELDSNnekglFRRGEAHL-------AVNDFDLARADFQKVLQLYPsNKAAKTQLAVCQQRTRRQlAREKKLYAN 413
Cdd:COG4700 146 TLEKLIAKNPD-----FKSSDAHLlyaraleALGDLEAAEAELEALARRYS-GPEARYRYAKFLARQGRT-AEAKELLEE 218


                ....*.
gi 13097417 414 MFERLA 419
Cdd:COG4700 219 ILDEAK 224
TPR_1 pfam00515
Tetratricopeptide repeat;
321-352 4.56e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.48  E-value: 4.56e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 13097417   321 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 275-411 8.11e-05

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 44.08  E-value: 8.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   275 ERGTAYFKEGKYKQALLQYKKIvswleyESSF-SGEEMQKVRalrlashLNLAMCHLKLQAFSAAIESCNKALELDSNNE 353
Cdd:TIGR03302  38 EEAKEALDSGDYTEAIKYFEAL------ESRYpFSPYAEQAQ-------LDLAYAYYKSGDYAEAIAAADRFIRLHPNHP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13097417   354 K---GLFRRGEAHLA-VNDFD-------LARADFQKVLQLYPSNK---AAKTQLAVCqqrtRRQLArEKKLY 411
Cdd:TIGR03302 105 DadyAYYLRGLSNYNqIDRVDrdqtaarEAFEAFQELIRRYPNSEyapDAKKRMDYL----RNRLA-GKELY 171
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 326-439 8.32e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 44.78  E-value: 8.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417  326 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 405
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13097417  406 REKKLYANMFERLAEEE-----HKVKAEVAAGDHPTDAE 439
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEE 143
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 322-352 8.49e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 8.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 13097417    322 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 352
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 246-408 8.91e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.07  E-value: 8.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   246 EVRLKSFEKAKESWEmsSAEKLEQSNIVKERGTAYFK--EGKYKQALLQYKKIVSwleyessfsgEEMQKVRALRLASHL 323
Cdd:TIGR02917 135 YLGLGQLELAQKSYE--QALAIDPRSLYAKLGLAQLAlaENRFDEARALIDEVLT----------ADPGNVDALLLKGDL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   324 NLAmchlkLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYP-SNKAAKTQLAVCQQRTRR 402
Cdd:TIGR02917 203 LLS-----LGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPnSPLAHYLKALVDFQKKNY 277


                  ....*.
gi 13097417   403 QLAREK 408
Cdd:TIGR02917 278 EDARET 283
TPR_1 pfam00515
Tetratricopeptide repeat;
354-386 5.02e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 5.02e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 13097417   354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 316-422 5.93e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 5.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 316 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAv 395
Cdd:COG2956   5 VAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA- 83

                        90       100       110
                ....*....|....*....|....*....|
gi 13097417 396 cqqrtrrQLAREKKLYA---NMFERLAEEE 422
Cdd:COG2956  84 -------QDYLKAGLLDraeELLEKLLELD 106
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 354-384 2.09e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 13097417   354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYP 384
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
346-402 2.27e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 2.27e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13097417 346 LELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 402
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR 57
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 277-395 2.34e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   277 GTAYFKEGKYKQALLQYKKIVSwleyessfSGEEMQKVRALrlashlnLAMCHLKLQAFSAAIESCNKALELDSNNE-KG 355
Cdd:TIGR02917  63 GKIYLALGDYAAAEKELRKALS--------LGYPKNQVLPL-------LARAYLLQGKFQQVLDELPGKTLLDDEGAaEL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 13097417   356 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 395
Cdd:TIGR02917 128 LALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQ 167
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 354-386 2.43e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 2.43e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 13097417    354 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 261-376 3.52e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 39.97  E-value: 3.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417   261 MSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSgeemqkvralrlashlNLAMCHLKLQAFSAAIE 340
Cdd:TIGR00990 118 LSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDPVYYS----------------NRAACHNALGDWEKVVE 181

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 13097417   341 SCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADF 376
Cdd:TIGR00990 182 DTTAALELDPDYSKALNRRANAYDGLGKYADALLDL 217
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 279-386 5.75e-03

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 37.91  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 279 AYFKEGKYKQALLQYKKIVSwleyesSFSGEEMQKVRALRLAShlnlamCHLKLQAFSAAIESCNKAlelDSNNEKGLF- 357
Cdd:COG2976  99 AAVDAGDLDKAAAQLQWVLD------NAKDPALKALARLRLAR------VLLAQKKYDEALATLDAV---KPEAFAALYa 163

                        90       100       110
                ....*....|....*....|....*....|
gi 13097417 358 -RRGEAHLAVNDFDLARADFQKVLQLYPSN 386
Cdd:COG2976 164 eLRGDILLAQGDKAEARAAYQKALAALPED 193
TPR_12 pfam13424
Tetratricopeptide repeat;
317-385 7.43e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 7.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13097417   317 LRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG--------LFRRGEAHLAVNDFDLARADFQKVLQLYPS 385
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPdhpltattLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
248-420 7.57e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 7.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 248 RLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIvswLEYESSFSgeemqkvralrlASHLNLAM 327
Cdd:COG0457  88 ALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA---LELDPDDA------------DALYNLGI 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13097417 328 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 407
Cdd:COG0457 153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232

                       170
                ....*....|...
gi 13097417 408 KKLYANMFERLAE 420
Cdd:COG0457 233 LRLAALALYQYRA 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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