NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29748041|gb|AAH50773|]
View 

ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 4.40e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 402.50  E-value: 4.40e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982  82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 29748041 277 HIAGFGYPDASNKKQTIHYYEQITLKSMAGSGHNVSQEAIAIKRM 321
Cdd:cd23982 160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 4.40e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 402.50  E-value: 4.40e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982  82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 29748041 277 HIAGFGYPDASNKKQTIHYYEQITLKSMAGSGHNVSQEAIAIKRM 321
Cdd:cd23982 160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 84-326 4.21e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 208.62  E-value: 4.21e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041    84 YELPFgtKGSEDLLLRVLAITSysipesIKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKT 163
Cdd:pfam00777  18 WWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041   164 TIRLFYPESA------HFDPKIENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQVRILNP 234
Cdd:pfam00777  90 TLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFLHP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041   235 FFMEIAADKLLSLPIQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaSNKKQTIHYYEQITLKSMAGSG-HNVSQ 313
Cdd:pfam00777 169 DFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGGFYGvHDMPF 243

                         250
                  ....*....|...
gi 29748041   314 EAIAIKRMLEMGA 326
Cdd:pfam00777 244 EFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 117-321 4.40e-143

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 402.50  E-value: 4.40e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMD 196
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQqpRKIKQKPTTGLLAITLALHLCDLV 276
Cdd:cd23982  82 FYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDEV 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 29748041 277 HIAGFGYPDASNKKQTIHYYEQITLKSMAGSGHNVSQEAIAIKRM 321
Cdd:cd23982 160 HIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 117-321 1.07e-110

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 320.39  E-value: 1.07e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkIENNPDTLLVLVAFKAMD 196
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDP-EEYDSDWLLVLVPFKSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FHWIETILSDKKRV-RKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQQpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23967  81 LLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCDE 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 29748041 276 VHIAGFGYpDASNKKQTIHYYEQITLKSMAGS-GHNVSQEAIAIKRM 321
Cdd:cd23967 160 VDIAGFGY-DPSDPNAPLHYYDSLTMKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 117-321 1.29e-81

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 246.58  E-value: 1.29e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkIENNPDTLLVLVAFKAMD 196
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDP-SHYDPNTTVVLIPFKPHD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQQPR-KIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23984  81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKeKKPKHPTTGIIAITLALHICNE 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 29748041 276 VHIAGFGYpDASNKKQTIHYYEQITLKSMAGSG-HNVSQEAIAIKRM 321
Cdd:cd23984 161 VHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 117-321 1.81e-66

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 208.05  E-value: 1.81e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAhfdPK--IENNPDTLLVLVAFKA 194
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKseQEYDPTSLFVAVLFKS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 195 MDFHWIETILSDKKR---VRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQQPR---KIKQKPTTGLLAITL 268
Cdd:cd23983  79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRlwgWDKNVPTLGVTAVVL 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 29748041 269 ALHLCDLVHIAGFGYpDASNKKQTIHYYEQITLKSMAGSG-HNVSQEAIAIKRM 321
Cdd:cd23983 159 ATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMNTQTmHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 84-326 4.21e-66

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 208.62  E-value: 4.21e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041    84 YELPFgtKGSEDLLLRVLAITSysipesIKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKT 163
Cdd:pfam00777  18 WWLPF--TVTEELLELLPKVSP------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041   164 TIRLFYPESA------HFDPKIENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQVRILNP 234
Cdd:pfam00777  90 TLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFLHP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041   235 FFMEIAADKLLSLPIQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaSNKKQTIHYYEQITLKSMAGSG-HNVSQ 313
Cdd:pfam00777 169 DFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGGFYGvHDMPF 243

                         250
                  ....*....|...
gi 29748041   314 EAIAIKRMLEMGA 326
Cdd:pfam00777 244 EFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 117-321 4.08e-58

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 186.67  E-value: 4.08e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPKiENNPDTLLVLVAFKAMD 196
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPE-QYEKDSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FHWIETIL-SDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPIQQPRKIKQK-PTTGLLAITLALHLCD 274
Cdd:cd23981  81 FKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNCD 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 29748041 275 LVHIAGFGYpDASNKKQTIHYYEQITLKSMAGS-GHNVSQEAIAIKRM 321
Cdd:cd23981 161 EVAVAGFGY-DMNTPNAPLHYYETIKMSAIKESwTHNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 117-328 2.28e-46

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 158.21  E-value: 2.28e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESA-HFDpkiennPDTLLVLVAFKAM 195
Cdd:cd23966  77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAvDLD------PGVHLVLVPFKVL 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 196 DFHWIETILSDKKRVRKgfWKQPPLIWDVNPKQVRILNPFFMEIAADKLLslpiqqpRKIKQKPTTGLLAITLALHLCDL 275
Cdd:cd23966 151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 276 VHIAGFGypdASNKKQTIHYYEQitlksMAGSG-------HNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23966 222 VSVFGFG---ADSKGNWHHYWEK-----NRSAGafrktgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 54-328 1.17e-41

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 146.63  E-value: 1.17e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041  54 QASKIFGNRSREQ-PIFLQLKDYF--WVKTPSTYELPFGTKG-SEDLLLRVLAITSYSIPESIKSLE-----CRRCVVVG 124
Cdd:cd23964  10 QKSPWFRERFIPDiKVLLDSEDFNpeEYNRLSHYKLPFGWGGlNREVVERLLRNLNLTSSRYMFVLRggrprCIRCAVVG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 125 NGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAH----FDPKIENnpDTLLVLVAFKAMDFHWI 200
Cdd:cd23964  90 NGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHnsllKHVPQDK--DTKYLFIPFKIRDYDYL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 201 ETILSDKKRVR---KGFWKQPPLIWDVNPKQVRILNPFFME-IAADKLLSLPIqqprkikQKPTTGLLAITLALHLCDLV 276
Cdd:cd23964 168 DAVLSGKPVPDgcdKGKRPPPLFGPKLNATNVRLLHPDFIRyLFNRWLNSSTS-------YRPTTGALMLLTALHTCDQV 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 29748041 277 HIAGFGYpdasNKKQTIHYYE-QITLKSMAGSGHNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23964 241 SVYGFGY----DPRFSLHYYDkTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 120-321 1.38e-38

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 135.57  E-value: 1.38e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 120 CVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHF--------DPKIENNPDTLLVLVA 191
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrgprcgCHPLPLEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 192 FKAMDFHWIetilsdkKRVRKGFWKQPPLiwdVNPKQVRILNpFFMEIaADKLLSLPIQQPRkikqKPTTGLLAITLALH 271
Cdd:cd19952  81 AAAADFKRL-------KRRKKRHDNAVLL---LTDPAPDLLS-YVRKR-LEKLGLKSFFGGN----APSSGLLAVLLALQ 144

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 29748041 272 LCDLVHIAGFGYPDASNKKQTIHYYEQITLKSMAGSgHNVSQEAIAIKRM 321
Cdd:cd19952 145 LCDSVDLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 115-298 4.35e-32

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 121.13  E-value: 4.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 115 LECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHFDPkiennPDTLLVLVAFKA 194
Cdd:cd23979  78 SRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKT 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 195 MDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQVRILNPFFMEIAADKLlslpiqqPRKIKQKPTTGLLAITLALHLCD 274
Cdd:cd23979 153 LDLLWITSALS-TGQIRFTYAPVKQFL-RVDKDKVQIYNPAFFKYIHDRW-------TEHHGRYPSTGMLVLFFALHVCD 223

                       170       180
                ....*....|....*....|....
gi 29748041 275 LVHIAGFGypdASNKKQTIHYYEQ 298
Cdd:cd23979 224 EVNVYGFG---ADSRGNWHHYWEN 244
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 113-297 2.17e-31

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 119.22  E-value: 2.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 113 KSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpkiENNPDTLLVLVAF 192
Cdd:cd23980  77 RLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPF 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 193 KAMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQVRILNPFFMEIAADKLLslpiqqpRKIKQKPTTGLLAITLALHL 272
Cdd:cd23980 152 KTLDLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-------QGHGRYPSTGILSVIFSLHV 222

                       170       180
                ....*....|....*....|....*
gi 29748041 273 CDLVHIAGFGypdASNKKQTIHYYE 297
Cdd:cd23980 223 CDEVDLYGFG---ADSKGNWHHYWE 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 118-328 6.38e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 104.27  E-value: 6.38e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 118 RRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKT---TI------RLFYPESAHFDPK-----IENNP 183
Cdd:cd23963  64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnltTLnpsilkRRYNSLKKNRDRDkflnrLKEYN 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 184 DTLLVLVAFkamdfhwietilSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLlslpiqQPRKIKQKPTTGL 263
Cdd:cd23963 144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW------KRRGLEKRPSTGL 205

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29748041 264 LAITLALHLCDLVHIAGFgYP---DASNKKQTIHYYEQITLKSMAGSgHNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23963 206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 118-321 9.18e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.81  E-value: 9.18e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 118 RRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRL-----FYPESAHFDPKIENNPDTLLV---- 188
Cdd:cd23968  46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLVwdps 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 189 ------LVAFKAMDFHWIET-----ILSDKKRVrkgFWKQPPLIWDVnpkqVRILNPFFmeiaadkllslpiqqPRKIKQ 257
Cdd:cd23968 126 synvnlEKWYKKPDFDFFPNyikyrRRHPEEPF---YLIDPRFLWRL----WDILQEYT---------------PEKIKP 183

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29748041 258 K-PTTGLLAITLALHLCDLVHIAGFgYPdaSNKKQTI-HYYEQITLKSMA-GSGHNVSQEAIAIKRM 321
Cdd:cd23968 184 NpPSSGFIGIVLMLHLCDWVDVYEY-VP--SVRQTDRcHYYDVEKDLACTlGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 114-297 4.13e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 100.21  E-value: 4.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 114 SLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTirlFYPESAH-------------FDpKIE 180
Cdd:cd23973  80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHsitsslmilqkrgFK-NIP 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 181 NNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIW---DVNPKQVRILNPFFMEIAADKLL-SLPIQQPRKIK 256
Cdd:cd23973 156 QDKDIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRYVKNRFLrSKTLKGKYWAI 235

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 29748041 257 QKPTTGLLAITLALHLCDLVHIAGF---GYPDASNkkqtiHYYE 297
Cdd:cd23973 236 YRPTTGAFLLLTALHLCDTVSAYGFiteDYRKYPD-----HYYD 274
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 71-297 7.82e-22

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 92.85  E-value: 7.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041  71 QLKDYFWVKTPSTYELPFGTKGSEDLLlrvlaiTSYSIPESIKSLecRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNA 150
Cdd:cd23985   7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPL--GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 151 PVAGYEGDVGSKTTIRLFYP-----ESAHFDPKIENNPDTLLVL--VAFKAMDFHWIET----ILSDKKRVRKGFWKQPP 219
Cdd:cd23985  79 PTAGFQQDVGTKTTIRLINSqlvttEKHKFLKDSLYNEGILIVWdpAPYHSDIPEWYKNpdynFFENYKTYRRLNPNQPF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 220 LIwdVNPKQVRILNPFFMEIAADKllslpIQqprkiKQKPTTGLLAITLALHLCDLVHIAGFgypdASNKKQT--IHYYE 297
Cdd:cd23985 159 YI--LHPQMQWELWDIIQENSPEE-----IQ-----PNPPSSGMLGIILMMTLCDQVDVYEF----LPSKRKTdvCHYYQ 222
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 117-302 2.47e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 90.76  E-value: 2.47e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFypesAHFD-PKIENNPDTLLVLVAFKAM 195
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 196 DFHWietiLSDKKRVRKGFwKQPPLIW---DVNPK-QVRILNPfFMEIAADKLLSLPIQQPRKI-KQKPTTGLLAITLAL 270
Cdd:cd23965  77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSRIKsGTWLSTGWFTMLLAL 150

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 29748041 271 HLCDLVHIAGFGYPD--ASNKKQTI--HYYEQITLK 302
Cdd:cd23965 151 DVCDEIKVYGMVPENycREHPNSKVpyHYYEPGGLK 186
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 113-328 4.37e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 83.26  E-value: 4.37e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 113 KSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFY-------------------PESA 173
Cdd:cd23974  80 GRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFStntlmnslrayagvgfngpPQSK 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 174 H----FDPkiENNPDTLLVLVAfkamdfhwIETILSDKKRVRKgfwKQPPLIW--DVNPKQVRILNPFFMEIAADKLLSL 247
Cdd:cd23974 160 EtryiFLP--DHDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWS 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 248 PIQQP--RKIkQKPTTGLLAITLALHLCDLVHIAGFGYPDASnkKQTIHYYEQITLKSMAGSGHNVSQEAIAIKRMLEMG 325
Cdd:cd23974 227 PILNTkqRDI-YRPSTGAVMLLAALHTCDQVSAYGFMTPDYG--KYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAG 303


                ...
gi 29748041 326 AVK 328
Cdd:cd23974 304 LIK 306
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 118-331 8.83e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 81.69  E-value: 8.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 118 RRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIrlfypesahfdpkIENNPDtlLVLVAFKAMDF 197
Cdd:cd23969  65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-------------TTMNPS--VIPHAYGDLVN 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 198 -HWIETILSDKKRVRKGFWKQPPLIWDVNPKQVRILNpffmEIAADKLLSLPIQQP-----RKIK----------QKPTT 261
Cdd:cd23969 130 aTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTN----EIILKHKLNVKTAYPplrlnHAIRgywlttkfriKRPST 205

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29748041 262 GLLAITLALHLCDLVHIAGFgYP---DASNKKQTIHYYEQITLKSMAgSGHNVSQEAIAIKRMLEMGAVKNLT 331
Cdd:cd23969 206 GLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYDNRKYLTTA-RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 63-321 1.06e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 81.42  E-value: 1.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041  63 SREQpIFLQLKDYFWVKTPSTYELPFGTKGSEDLLLRvlaitsysIPES-IKSLECRRCVVVGNGHRLRNSSLGGVINKY 141
Cdd:cd23986   3 SRQE-LLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSkLHLRGFRSCAVVTSAGAILNSSLGKEIDSH 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 142 DVVIRLNNAPVAGYEGDVGSKTTIRLFYPE-----SAHFdpkIENNPDTLLVLVAFK----AMDFH-WIE----TILSDK 207
Cdd:cd23986  74 DAVLRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHF---IDSSLYKDVILVAWDpapySANLHkWYKkpdyNLFTPY 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 208 KRVRKGFWKQPPLIwdVNPKQVRILNPFFMEIAADKLlslpiqQPrkikQKPTTGLLAITLALHLCDLVHIagFGYPDAS 287
Cdd:cd23986 151 VQYRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QP----NPPSSGFIGILIMMSMCREVHV--YEYIPSV 216

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 29748041 288 NKKQTIHYYEQ-----ITLksmaGSGHNVSQEAIAIKRM 321
Cdd:cd23986 217 RQTDLCHYHERyydaaCTL----GAYHPLLYEKLLIQRM 251
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 106-328 5.38e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 79.74  E-value: 5.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 106 YSIPESIKSL----------ECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHf 175
Cdd:cd23970  47 FSISPNLRSLlpevspfqnkHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILE- 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 176 dpKIENNPDTLLVLVAFkamdfhwietiLSDKKRVRKGFWKQPPLIWDVNPKQVRILNPFFMEIAADKLLSLPI------ 249
Cdd:cd23970 126 --KYYNNLLTIQDRNNF-----------FLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWpgnimq 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 250 ----------QQPRKIkqkpTTGLLAITLALHLCDLVHIAGFgYP---DASNKKQTIHYYEQITLKSMAG--SGHNVSQE 314
Cdd:cd23970 193 hvnrywktkhLSPKRL----STGILMYTLASAICEEIHLYGF-WPfgfDPTGTPLPYHYYDKKGTKFTTKwqESHQLPAE 267

                       250
                ....*....|....
gi 29748041 315 AIAIKRMLEMGAVK 328
Cdd:cd23970 268 FVLLYKMHGAGVLK 281
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 108-328 1.17e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 78.84  E-value: 1.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 108 IPE--SIKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYP--------------E 171
Cdd:cd23988  53 LPEvsPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPsvvqrafggfrnesD 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 172 SAHFDPKIENNPDTLLVLVAF--KAMDFH--WI-ETILSDKKRVRKGFwkqppliwdvnpkqvrilnPFFMEIAADKLLS 246
Cdd:cd23988 133 REKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY-------------------PSLRLIHAVRGYW 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 247 LPIQQPRKikqKPTTGLLAITLALHLCDLVHIAGF-GYP-DASNKKQTIHYYEQITLKSMAGSG-HNVSQEAIAIKRMLE 323
Cdd:cd23988 194 LTNKVNIK---RPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHRMPLEFKTLNVLHN 270


                ....*
gi 29748041 324 MGAVK 328
Cdd:cd23988 271 RGALK 275
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 119-328 6.42e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 73.45  E-value: 6.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 119 RCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAgYEGDVGSKTT--------IRLFYPE----SAHFDPKIENNPDTL 186
Cdd:cd23971  66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNlvtanpsiLREKFHNlkkrRRPFVERMKVYGNAL 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 187 LVLVAFKamdFHwIETILSDK-KRVRKGFwkqppliwdVNPKQVRILNPFFMEIAADKLLSLPIQQPRkikqkPTTGLLA 265
Cdd:cd23971 145 LLLPAFS---YT-SNTEPSLRaLYTLEDF---------GSPQKVLFFNPEYLRNLSRYWKSKGLKARR-----LSTGLML 206

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29748041 266 ITLALHLCDLVHIAGFgYP---DASNKKQTIHYYEQItlksMAGSG-HNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23971 207 VSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNV----LPKKGvHAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 82-328 2.18e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.55  E-value: 2.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041  82 STYELPFGTKG--SEDL--LLRVLAITSYS--IPESIKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGY 155
Cdd:cd23972  41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 156 EGDVGSKTTirlFYpesaHFDPKIENNPdtllvLVAFKAMDFH-----------WIETILSDKKRVRKGFWKQP-PLIWD 223
Cdd:cd23972 121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 224 ------------VNPKQVRILNPFFMEIAADKLL-SLPIQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAsnKK 290
Cdd:cd23972 189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLkSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFITSNY--WK 266

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 29748041 291 QTIHYYEQITLKSMAGSGHNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23972 267 FSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 112-328 3.31e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 71.51  E-value: 3.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 112 IKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYP---ESAHFDPKIENNPDTLLV 188
Cdd:cd23987  59 LKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPsvvQRAFEDLVNETWKEKFLQ 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 189 LVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNpkqVRILNPFFMEIAADKLLSLpiQQPRKIKqKPTTGLLAITL 268
Cdd:cd23987 139 RLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHIN---VRTAYPSLRLLHAVRGYWL--TNKVHIK-RPTTGLLMYTL 212

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29748041 269 ALHLCDLVHIAGFgYP---DASNKKQTIHYYEQITLK-SMAGSGHNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23987 213 ATRFCNRIHLYGF-WPfprDQNQNPVKYHYYDSLKYGyTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 117-297 9.54e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.50  E-value: 9.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDTLLVLVAFKAMD 196
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 197 FhW--IETILSDKKRVRKGFWKQPPLI------WDVNPKQVRILNPFF-MEIAADKllslpiqqpRKIKQKPTTGLLAIT 267
Cdd:cd23978  78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFDDLFrGETGRDR---------KKSHSWLSTGWFTMV 147

                       170       180       190
                ....*....|....*....|....*....|....*
gi 29748041 268 LALHLCDLVHIAGFGYPDASNKKQTI-----HYYE 297
Cdd:cd23978 148 IAVELCDNVHVYGMVPPNYCSKRPTPkkmpyHYYE 182
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 110-328 6.36e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 64.78  E-value: 6.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 110 ESIKSLECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEG-DVGSKTT--------IRLFYPE----SAHFD 176
Cdd:cd23991  57 QPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISkDVGSKTNlvtanpsiISIKYAKlnerRKPFL 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 177 PKIENNPDTLLVLVAFK-----AMDFHWIETILSDKKRVRKGFWkqppliwdvNPKQVRILNPFFmeiaadklLSLPIQQ 251
Cdd:cd23991 137 ETVSVYGDAFLLLPAFSyrsntALSFKVYYTLEDFKAKQKVIFF---------HPIYLKHLAQFW--------RSKGVQV 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 252 PRKikqkpTTGLLAITLALHLCDLVHIAGFgYPDASN---KKQTIHYYEQITLKSmagSGHNVSQEAIAIKRMLEMGAVK 328
Cdd:cd23991 200 YRL-----STGLMITSAALELCEEVKLYGF-WPFSKNtegKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 117-167 7.29e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.03  E-value: 7.29e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRL 167
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 115-297 2.34e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 59.88  E-value: 2.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 115 LECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAHfdpKIENNPDTLLVlVAFKA 194
Cdd:cd23976  13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQGT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 195 MDFHWIETilSDKKRVRKGF-WKQPPLIWDVNPK-QVRILNPFFMeIAADKLLSLPIQQPRKIKQK-PTTGLLAITLALH 271
Cdd:cd23976  89 VFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIALE 165

                       170       180       190
                ....*....|....*....|....*....|
gi 29748041 272 LCDLVHIAGFGYPD--ASNKKQTI--HYYE 297
Cdd:cd23976 166 LCDRINVYGMVPPDfcRDPNHPSVpyHYYE 195
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 118-299 1.66e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 57.92  E-value: 1.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 118 RRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAG-YEGDVGSKTTIRLFYP----ESAH--------FDPKIENNPD 184
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYEN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 185 TLLVLVAFkamdFHWIETILSDK-KRVRKGFwkqppliwdVNPKQVRILNPFFMEIAADKLLSLPIQQPRkikqkPTTGL 263
Cdd:cd23990 145 ASVVLPAF----YNTRNTDVSIRvKYVLDDF---------ESQQAVYYFHPQYLLNVSRFWLRQGVRAKR-----ISSGL 206

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 29748041 264 LAITLALHLCDLVHIAGF-GYP-DASNKKQTIHYYEQI 299
Cdd:cd23990 207 MLVTAALELCEEVHLYGFwAFPmNPSGIFITHHYYDNV 244
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 115-299 3.08e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 57.15  E-value: 3.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 115 LECRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVA-GYEGDVGSKTTIRLFYPESahfdpkIENNPDTLL-----V 188
Cdd:cd23989  61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANPSI------IDKRFQNLLwsrksF 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29748041 189 LVAFKAMDFHWIET-ILSDKKRVRKGFWKQPPLIwDVNPKQ-VRILNPFFMEiaadkllslPIQQPRKIK----QKPTTG 262
Cdd:cd23989 135 VESMKVYGRSYIYMpAFSMKTGTDPSLRVYYTLA-DVGANQtVLFANPNFLR---------NVGKFWKSKgvhaKRLSTG 204

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 29748041 263 LLAITLALHLCDLVHIAGFgYP---DASNKKQTIHYYEQI 299
Cdd:cd23989 205 LFLVSAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNV 243
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 117-184 1.28e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.47  E-value: 1.28e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29748041 117 CRRCVVVGNGHRLRNSSLGGVINKYDVVIRLNNAPVAGYEGDVGSKTTIRLFYPESAhfdPKIENNPD 184
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH