NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|49901405|gb|AAH76625|]
View 

Fibronectin type III domain containing 3C1 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 13457450)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
970-1202 3.10e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 96.61  E-value: 3.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  970 YEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVEskvpakLSSTCIAIRWEEPDchGSPITGYN 1049
Cdd:COG3401  194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA------DTPGSVTLSWDPVT--ESDATGYR 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1050 IEYGD------KKVVTVKRiTEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLR 1121
Cdd:COG3401  266 VYRSNsgdgpfTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSIT 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1122 LKWGTVSSkktlANFINYNVL-MEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKS 1198
Cdd:COG3401  345 LSWTASSD----ADVTGYNVYrSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASA 420


                 ....
gi 49901405 1199 PPTA 1202
Cdd:COG3401  421 ASGE 424
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 551-641 3.88e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 3.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  551 PDPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HKLFKLNPSTKYSFRLAAKNDF 628
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 49901405  629 GCSNFSETAVFYT 641
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 915-1004 2.25e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  915 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAEIIDYRLQWGQVEDSMHLIYTGPC---LRYEVKGLVPATTYFCRVQAVNIV 991
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 49901405  992 GVGMFGGTAKVTT 1004
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
708-844 5.10e-09

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 5.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  708 NLQRNTMYKFRIFAYNLEGRSNPSGEVKYTTRPARPGCPnKPYVVGTIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSD 787
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP-TGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGD 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 49901405  788 SAnlWKIIYSGTRQEFLYDDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPES 844
Cdd:COG3401  274 GP--FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA 329
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 661-738 6.58e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.58e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405  661 SLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFK-PKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRSNPSGEVKYTT 738
Cdd:cd00063   16 SVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
337-764 7.55e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 7.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  337 CSDNNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANM 416
Cdd:COG3401   23 VNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  417 GAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPGcFNIEKPVVSNIQTRSATVSWTRKSNEKYDINSSMTHELALSSNG 496
Cdd:COG3401  103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAAT-AGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  497 KNGTYKNIYTGNGVTVvlhDLQPCMVYFLRVTTIRNAEHRSVSEVVSFTTPGCEPDPPLAPTLISRTKNSLSLQWKASND 576
Cdd:COG3401  182 TTSLTVTSTTLVDGGG---DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  577 NGskISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDFGC-SNFSETAVFYTSGKTPPAPLPPKLK 655
Cdd:COG3401  259 SD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTAT 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  656 EAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGR-SNPSGEV 734
Cdd:COG3401  337 AVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413

                        410       420       430
                 ....*....|....*....|....*....|
gi 49901405  735 KYTTRPARPGCPNKPYVVGTIHAHQVTIGW 764
Cdd:COG3401  414 SATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1200-1296 5.28e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1200 PTALKAPKVHPLNNNSCEIKWESLEPIKGDPIVYCLQVTTGKKAN----QIYKGPNTSFSFSNYHANSRYRFKVCAgrry 1275
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRA---- 76

                         90       100
                 ....*....|....*....|.
gi 49901405 1276 ETSNGlqelWGPYSPSALFST 1296
Cdd:cd00063   77 VNGGG----ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
970-1202 3.10e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 96.61  E-value: 3.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  970 YEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVEskvpakLSSTCIAIRWEEPDchGSPITGYN 1049
Cdd:COG3401  194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA------DTPGSVTLSWDPVT--ESDATGYR 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1050 IEYGD------KKVVTVKRiTEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLR 1121
Cdd:COG3401  266 VYRSNsgdgpfTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSIT 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1122 LKWGTVSSkktlANFINYNVL-MEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKS 1198
Cdd:COG3401  345 LSWTASSD----ADVTGYNVYrSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASA 420


                 ....
gi 49901405 1199 PPTA 1202
Cdd:COG3401  421 ASGE 424
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1026-1100 7.16e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 7.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1026 LSSTCIAIRWEEPDCHGSPITGYNIEYGDKKVVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 1098
Cdd:cd00063   12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                 ..
gi 49901405 1099 KT 1100
Cdd:cd00063   92 TT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 551-641 3.88e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 3.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  551 PDPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HKLFKLNPSTKYSFRLAAKNDF 628
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 49901405  629 GCSNFSETAVFYT 641
Cdd:cd00063   81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1026-1093 7.68e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 7.68e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49901405   1026 LSSTCIAIRWEEPDCHGSPITGYNIEY------GDKKVVTVKR-ITEYVLKDLQPNTTYRIRIQAINHYGLSPFS 1093
Cdd:pfam00041   11 VTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGtTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1027-1090 8.47e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 8.47e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49901405    1027 SSTCIAIRWEEP--DCHGSPITGYNIEYGD-----KKVVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLS 1090
Cdd:smart00060   13 TSTSVTLSWEPPpdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 915-1004 2.25e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  915 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAEIIDYRLQWGQVEDSMHLIYTGPC---LRYEVKGLVPATTYFCRVQAVNIV 991
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 49901405  992 GVGMFGGTAKVTT 1004
Cdd:cd00063   81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
552-634 1.10e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405    552 DPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLE-WDEGKGEDFKSCY-SGRLKQHKLFKLNPSTKYSFRLAAKNDFG 629
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 49901405    630 CSNFS 634
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
927-996 2.78e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.78e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49901405    927 GPTCVIVSWEIPKCNGAEIIDYRLQWGQV---EDSMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGVGMF 996
Cdd:pfam00041   12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKnsgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
708-844 5.10e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 5.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  708 NLQRNTMYKFRIFAYNLEGRSNPSGEVKYTTRPARPGCPnKPYVVGTIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSD 787
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP-TGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGD 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 49901405  788 SAnlWKIIYSGTRQEFLYDDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPES 844
Cdd:COG3401  274 GP--FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA 329
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 551-631 5.59e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.59e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405     551 PDPPLAPTLISRTKNSLSLQWKASNDNG--SKISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDF 628
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 49901405     629 GCS 631
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 661-738 6.58e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.58e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405  661 SLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFK-PKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRSNPSGEVKYTT 738
Cdd:cd00063   16 SVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 752-837 7.18e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 7.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  752 VGTIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDSAnlWKII--YSGTRQEFLYDDLQAATTYKLRVFCTSPAGQSRP 829
Cdd:cd00063    9 VTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                 ....*...
gi 49901405  830 SDVLTIQT 837
Cdd:cd00063   86 SESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 915-994 7.27e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 7.27e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405     915 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAE--IIDYRLQWGQVEDS-MHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIV 991
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 49901405     992 GVG 994
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
337-764 7.55e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 7.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  337 CSDNNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANM 416
Cdd:COG3401   23 VNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  417 GAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPGcFNIEKPVVSNIQTRSATVSWTRKSNEKYDINSSMTHELALSSNG 496
Cdd:COG3401  103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAAT-AGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  497 KNGTYKNIYTGNGVTVvlhDLQPCMVYFLRVTTIRNAEHRSVSEVVSFTTPGCEPDPPLAPTLISRTKNSLSLQWKASND 576
Cdd:COG3401  182 TTSLTVTSTTLVDGGG---DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  577 NGskISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDFGC-SNFSETAVFYTSGKTPPAPLPPKLK 655
Cdd:COG3401  259 SD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTAT 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  656 EAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGR-SNPSGEV 734
Cdd:COG3401  337 AVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413

                        410       420       430
                 ....*....|....*....|....*....|
gi 49901405  735 KYTTRPARPGCPNKPYVVGTIHAHQVTIGW 764
Cdd:COG3401  414 SATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 661-728 1.69e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.69e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49901405     661 SLSLEWCAPTNPNPNDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRS 728
Cdd:smart00060   16 SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
PRK08581 PRK08581
amidase domain-containing protein;
271-509 1.39e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 46.32  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405   271 TVDTAPGTNTDNSTSDTYSLNTVLNTCTIDSAPRNMADNIPDTNTTDTITSSSAHTPSISTSNATFCSDNNNNITDSSIS 350
Cdd:PRK08581   21 TSPTAYADDPQKDSTAKTTSHDSKKSNDDETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDSNNIIDFIYKNLP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405   351 NYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANmgagdNKQILGENQK 430
Cdd:PRK08581  101 QTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQS-----SKQDKADNQK 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405   431 KSQSSNASLKEHNTEDRTQPGCFNIEKPVVSNIQTRSATVSwTRKSNEKYDiNSSMTHELALSSNGKNGTYKNiYTGNG 509
Cdd:PRK08581  176 APSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKS-SSKDNQSMS-DSALDSILDQYSEDAKKTQKD-YASQS 251
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 751-827 7.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 7.13e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405     751 VVGTIHAHQVTIGWDLPKDNGGMN-ISSYSLEVCENSDSanlWKIIYSGTRQ-EFLYDDLQAATTYKLRVFCTSPAGQS 827
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSE---WKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
660-731 3.62e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49901405    660 YSLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFKPKYNGEDL-TCTIRNLQRNTMYKFRIFAYNLEGRSNPS 731
Cdd:pfam00041   14 TSLTVSWTPPPDGNGPIT-GYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1200-1296 5.28e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1200 PTALKAPKVHPLNNNSCEIKWESLEPIKGDPIVYCLQVTTGKKAN----QIYKGPNTSFSFSNYHANSRYRFKVCAgrry 1275
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRA---- 76

                         90       100
                 ....*....|....*....|.
gi 49901405 1276 ETSNGlqelWGPYSPSALFST 1296
Cdd:cd00063   77 VNGGG----ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1166-1271 6.82e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 6.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1166 LSEYTEYKFKIQACNEAGEGPESDIYTFTTTKSPPTALKAPKVHPLNNNSCEIKWES--LEPIKGdPIVYcLQVTTGKKA 1243
Cdd:COG3401  199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDATG-YRVY-RSNSGDGPF 276

                         90       100
                 ....*....|....*....|....*...
gi 49901405 1244 NQIYKGPNTSFSFSNYHANSRYRFKVCA 1271
Cdd:COG3401  277 TKVATVTTTSYTDTGLTNGTTYYYRVTA 304
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
970-1202 3.10e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 96.61  E-value: 3.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  970 YEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVEskvpakLSSTCIAIRWEEPDchGSPITGYN 1049
Cdd:COG3401  194 DGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA------DTPGSVTLSWDPVT--ESDATGYR 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1050 IEYGD------KKVVTVKRiTEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLR 1121
Cdd:COG3401  266 VYRSNsgdgpfTKVATVTT-TSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSIT 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1122 LKWGTVSSkktlANFINYNVL-MEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKS 1198
Cdd:COG3401  345 LSWTASSD----ADVTGYNVYrSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASA 420


                 ....
gi 49901405 1199 PPTA 1202
Cdd:COG3401  421 ASGE 424
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1026-1100 7.16e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 7.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1026 LSSTCIAIRWEEPDCHGSPITGYNIEYGDKKVVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 1098
Cdd:cd00063   12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                 ..
gi 49901405 1099 KT 1100
Cdd:cd00063   92 TT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 551-641 3.88e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 3.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  551 PDPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HKLFKLNPSTKYSFRLAAKNDF 628
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 49901405  629 GCSNFSETAVFYT 641
Cdd:cd00063   81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1026-1093 7.68e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 7.68e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49901405   1026 LSSTCIAIRWEEPDCHGSPITGYNIEY------GDKKVVTVKR-ITEYVLKDLQPNTTYRIRIQAINHYGLSPFS 1093
Cdd:pfam00041   11 VTSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGtTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
926-1178 4.36e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 4.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  926 KGPTCVIVSWEIPKCNGAEiiDYRLQWGQVED-SMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGV-GMFGGTAKVT 1003
Cdd:COG3401  244 DTPGSVTLSWDPVTESDAT--GYRVYRSNSGDgPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVT 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1004 TPGTVPAmVPVLKEVESKVPAKlsstcIAIRWEEPDchGSPITGYNIEYGDKKVVTVKRI------TEYVLKDLQPNTTY 1077
Cdd:COG3401  322 TDLTPPA-APSGLTATAVGSSS-----ITLSWTASS--DADVTGYNVYRSTSGGGTYTKIaetvttTSYTDTGLTPGTTY 393

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1078 RIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQLNCVVYGHQSLRLKWGTVSSKKTLANFINYNVLMEDRSGRFSVIYRG 1156
Cdd:COG3401  394 YYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTT 473

                        250       260
                 ....*....|....*....|..
gi 49901405 1157 PDVTHKVQKLSEYTEYKFKIQA 1178
Cdd:COG3401  474 SSTVTATTTDTTTANLSVTTGS 495
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1027-1090 8.47e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 8.47e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 49901405    1027 SSTCIAIRWEEP--DCHGSPITGYNIEYGD-----KKVVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLS 1090
Cdd:smart00060   13 TSTSVTLSWEPPpdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
957-1222 1.43e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.88  E-value: 1.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  957 DSMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGVGMFGGTAKVTTPGTVPAMVPVLKEVESKVPAKLSStciAIRWE 1036
Cdd:COG3401   88 PPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTT---ASSVA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1037 EPDCHGSPITGYNIEYGDKKVVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRCKTKPLPPEPPQ-LNCVVY 1115
Cdd:COG3401  165 GAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTgLTATAD 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1116 GHQSLRLKWgtvsSKKTLANFINYNVL-MEDRSGRFSVIYRGPDVTHKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTF 1193
Cdd:COG3401  245 TPGSVTLSW----DPVTESDATGYRVYrSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSV 320

                        250       260
                 ....*....|....*....|....*....
gi 49901405 1194 TTTKSPPTALKAPKVHPLNNNSCEIKWES 1222
Cdd:COG3401  321 TTDLTPPAAPSGLTATAVGSSSITLSWTA 349
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 915-1004 2.25e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  915 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAEIIDYRLQWGQVEDSMHLIYTGPC---LRYEVKGLVPATTYFCRVQAVNIV 991
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 49901405  992 GVGMFGGTAKVTT 1004
Cdd:cd00063   81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
552-634 1.10e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405    552 DPPLAPTLISRTKNSLSLQWKASNDNGSKISSFLLE-WDEGKGEDFKSCY-SGRLKQHKLFKLNPSTKYSFRLAAKNDFG 629
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 49901405    630 CSNFS 634
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
927-996 2.78e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.78e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49901405    927 GPTCVIVSWEIPKCNGAEIIDYRLQWGQV---EDSMHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIVGVGMF 996
Cdd:pfam00041   12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKnsgEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1104-1195 3.20e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 3.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1104 PPEPPQLNCVVYGHQSLRLKWgtVSSKKTLANFINYNVLMEDRSGRFSVIYRGPDVT---HKVQKLSEYTEYKFKIQACN 1180
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW--TPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSetsYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 49901405 1181 EAGEGPESDIYTFTT 1195
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
708-844 5.10e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 5.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  708 NLQRNTMYKFRIFAYNLEGRSNPSGEVKYTTRPARPGCPnKPYVVGTIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSD 787
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAP-TGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGD 273

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 49901405  788 SAnlWKIIYSGTRQEFLYDDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPES 844
Cdd:COG3401  274 GP--FTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA 329
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 551-631 5.59e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.59e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405     551 PDPPLAPTLISRTKNSLSLQWKASNDNG--SKISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDF 628
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 49901405     629 GCS 631
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 661-738 6.58e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 6.58e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405  661 SLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFK-PKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRSNPSGEVKYTT 738
Cdd:cd00063   16 SVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 752-837 7.18e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 7.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  752 VGTIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDSAnlWKII--YSGTRQEFLYDDLQAATTYKLRVFCTSPAGQSRP 829
Cdd:cd00063    9 VTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85


                 ....*...
gi 49901405  830 SDVLTIQT 837
Cdd:cd00063   86 SESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 915-994 7.27e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 7.27e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405     915 PSQCGTPVLTCKGPTCVIVSWEIPKCNGAE--IIDYRLQWGQVEDS-MHLIYTGPCLRYEVKGLVPATTYFCRVQAVNIV 991
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 49901405     992 GVG 994
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
612-842 2.26e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 2.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  612 LNPSTKYSFRLAAKNDFGCSNFSETAVFYTSGKTPPAPLPPKLKEAGIYSLSLEWcaptNPNPNDTLT-YVLEMEEAKSG 690
Cdd:COG3401  199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW----DPVTESDATgYRVYRSNSGDG 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  691 lGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEG-RSNPSGEVKYTTRPARPGCPnkPYVVGTIHAH-QVTIGWDLPK 768
Cdd:COG3401  275 -PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAP--SGLTATAVGSsSITLSWTASS 351

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49901405  769 DNggmNISSYSLEVCENSDSAnlWKIIYSGTRQEFLYD-DLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPP 842
Cdd:COG3401  352 DA---DVTGYNVYRSTSGGGT--YTKIAETVTTTSYTDtGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAAS 422
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
265-782 3.81e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  265 DSLCPYTVDTAPGTNTDNSTSDTYSLNTVLNTCTIDSAPRNMADNIPDT--------NTTDTITSSSAHTPSISTSNATF 336
Cdd:COG3401   38 VYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAapptatglTTLTGSGSVGGATNTGLTSSDEV 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  337 CSD---NNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLrPSDVASISENDHEETE 413
Cdd:COG3401  118 PSPavgTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV-ATTSLTVTSTTLVDGG 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  414 ANMGAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPgcfniEKP---VVSNIQTRSATVSWTRKSNE---KYDInssmt 487
Cdd:COG3401  197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP-----SAPtglTATADTPGSVTLSWDPVTESdatGYRV----- 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  488 helaLSSNGKNGTYKNIYTGNGVTVVLHDLQPCMVYFLRVTTIRNAEHRSV-SEVVSFTTPGCEPDPPLAPTLISRTKNS 566
Cdd:COG3401  267 ----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESApSNVVSVTTDLTPPAAPSGLTATAVGSSS 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  567 LSLQWKASNDNGskISSFLLEWDEGKGEDFKSCYSGRLK-QHKLFKLNPSTKYSFRLAAKNDFGCSNFSETAVFYTSGKT 645
Cdd:COG3401  343 ITLSWTASSDAD--VTGYNVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASA 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  646 PPAPLPPKLKEAGIYSLSLEWCAPTNPNPNDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLE 725
Cdd:COG3401  421 ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGS 500

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 49901405  726 GRSNPSGEVKYttrparPGCPNKPYVVGTIHAHQVTIGWDLPKDNGGMNISSYSLEV 782
Cdd:COG3401  501 GASSVTNSVSV------IGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLV 551
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
337-764 7.55e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 7.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  337 CSDNNNNITDSSISNYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANM 416
Cdd:COG3401   23 VNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  417 GAGDNKQILGENQKKSQSSNASLKEHNTEDRTQPGcFNIEKPVVSNIQTRSATVSWTRKSNEKYDINSSMTHELALSSNG 496
Cdd:COG3401  103 VGGATNTGLTSSDEVPSPAVGTATTATAVAGGAAT-AGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  497 KNGTYKNIYTGNGVTVvlhDLQPCMVYFLRVTTIRNAEHRSVSEVVSFTTPGCEPDPPLAPTLISRTKNSLSLQWKASND 576
Cdd:COG3401  182 TTSLTVTSTTLVDGGG---DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  577 NGskISSFLLEWDEGKGEDFKSCYSGRLKQHKLFKLNPSTKYSFRLAAKNDFGC-SNFSETAVFYTSGKTPPAPLPPKLK 655
Cdd:COG3401  259 SD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTAT 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405  656 EAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGR-SNPSGEV 734
Cdd:COG3401  337 AVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413

                        410       420       430
                 ....*....|....*....|....*....|
gi 49901405  735 KYTTRPARPGCPNKPYVVGTIHAHQVTIGW 764
Cdd:COG3401  414 SATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1104-1185 2.22e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 2.22e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405    1104 PPEPPQLNCVVYGHQSLRLKWGTVSSKKTLANFINYNVLMEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEA 1182
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 49901405    1183 GEG 1185
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 661-728 1.69e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.69e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49901405     661 SLSLEWCAPTNPNPNDTLTYVLEMEEAKSGLGFKPKYNGEDLTCTIRNLQRNTMYKFRIFAYNLEGRS 728
Cdd:smart00060   16 SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
PRK08581 PRK08581
amidase domain-containing protein;
271-509 1.39e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 46.32  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405   271 TVDTAPGTNTDNSTSDTYSLNTVLNTCTIDSAPRNMADNIPDTNTTDTITSSSAHTPSISTSNATFCSDNNNNITDSSIS 350
Cdd:PRK08581   21 TSPTAYADDPQKDSTAKTTSHDSKKSNDDETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDSNNIIDFIYKNLP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405   351 NYNQVTYDETHKPPDAKSIPSCTSQSASNPSVSENAHNPSSINDGLRPSDVASISENDHEETEANmgagdNKQILGENQK 430
Cdd:PRK08581  101 QTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQS-----SKQDKADNQK 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405   431 KSQSSNASLKEHNTEDRTQPGCFNIEKPVVSNIQTRSATVSwTRKSNEKYDiNSSMTHELALSSNGKNGTYKNiYTGNG 509
Cdd:PRK08581  176 APSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKS-SSKDNQSMS-DSALDSILDQYSEDAKKTQKD-YASQS 251
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 751-827 7.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 7.13e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 49901405     751 VVGTIHAHQVTIGWDLPKDNGGMN-ISSYSLEVCENSDSanlWKIIYSGTRQ-EFLYDDLQAATTYKLRVFCTSPAGQS 827
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSE---WKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1105-1188 1.04e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405   1105 PEPPQLNCVVYGHQSLRLKWGTVSSKKtlANFINYNVLMEDRSG-----RFSViyRGPDVTHKVQKLSEYTEYKFKIQAC 1179
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGN--GPITGYEVEYRPKNSgepwnEITV--PGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 49901405   1180 NEAGEGPES 1188
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
660-731 3.62e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49901405    660 YSLSLEWCAPTNPNPNDTlTYVLEMEEAKSGLGFKPKYNGEDL-TCTIRNLQRNTMYKFRIFAYNLEGRSNPS 731
Cdd:pfam00041   14 TSLTVSWTPPPDGNGPIT-GYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1200-1296 5.28e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1200 PTALKAPKVHPLNNNSCEIKWESLEPIKGDPIVYCLQVTTGKKAN----QIYKGPNTSFSFSNYHANSRYRFKVCAgrry 1275
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDwkevEVTPGSETSYTLTGLKPGTEYEFRVRA---- 76

                         90       100
                 ....*....|....*....|.
gi 49901405 1276 ETSNGlqelWGPYSPSALFST 1296
Cdd:cd00063   77 VNGGG----ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1166-1271 6.82e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 6.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49901405 1166 LSEYTEYKFKIQACNEAGEGPESDIYTFTTTKSPPTALKAPKVHPLNNNSCEIKWES--LEPIKGdPIVYcLQVTTGKKA 1243
Cdd:COG3401  199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtESDATG-YRVY-RSNSGDGPF 276

                         90       100
                 ....*....|....*....|....*...
gi 49901405 1244 NQIYKGPNTSFSFSNYHANSRYRFKVCA 1271
Cdd:COG3401  277 TKVATVTTTSYTDTGLTNGTTYYYRVTA 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH