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Conserved domains on  [gi|51703369|gb|AAH80903|]
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keap1 protein [Xenopus tropicalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-148 6.33e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 253.07  E-value: 6.33e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRL 104
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLD 148
Cdd:cd18248  81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 146-236 2.21e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


:

Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 198.29  E-value: 2.21e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 51703369 226 ENRRPYIQALL 236
Cdd:cd18458  81 ENRRQYLEALL 91
PHA03098 super family cl33709
kelch-like protein; Provisional
 43-560 6.27e-61

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 211.55  E-value: 6.27e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369   43 QQLCDVKLKVKYND--VQdefvAHKIVLASSSPVFRAMFTNGLREcgmETVTIEGVHpKVMQRLLEFAYTASISVGEKCV 120
Cdd:PHA03098   7 QKFCDESIIIVNGGgiIK----VHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  121 IHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLV 200
Cdd:PHA03098  79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  201 SRDELNVRCESEVFHACINWVKYDCENRRPYIQALLRAVRCHSLTPNFLQlQLQRCEILKGDS------RCqdYLSQIFQ 274
Cdd:PHA03098 159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKKKkivfnkRC--IKIIYSK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  275 DLTLHKPTLplqgRIPNVPQFIYVAGGYYRQSLSFLEAYNPVDgEWLTLASleMPRSGLAGCV-LGGLFYAVGGRNNAPD 353
Cdd:PHA03098 236 KYNLNKILP----RSSTFGSIIYIHITMSIFTYNYITNYSPLS-EINTIID--IHYVYCFGSVvLNNVIYFIGGMNKNNL 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  354 CNKDSGAldcYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGV 433
Cdd:PHA03098 309 SVNSVVS---YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCV 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  434 AVLNRLLYAVGG-FDGTNRLNSAECYYPETDEWKDIASMNIVRSGAGACALDTSVYAMGGYDGTDQ---LNSVERYDVEK 509
Cdd:PHA03098 386 VNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNikvYNIVESYNPVT 465

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 51703369  510 DDWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWT 560
Cdd:PHA03098 466 NKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
 
Name Accession Description Interval E-value
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-148 6.33e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 253.07  E-value: 6.33e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRL 104
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLD 148
Cdd:cd18248  81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 146-236 2.21e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 198.29  E-value: 2.21e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 51703369 226 ENRRPYIQALL 236
Cdd:cd18458  81 ENRRQYLEALL 91
PHA03098 PHA03098
kelch-like protein; Provisional
 43-560 6.27e-61

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 211.55  E-value: 6.27e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369   43 QQLCDVKLKVKYND--VQdefvAHKIVLASSSPVFRAMFTNGLREcgmETVTIEGVHpKVMQRLLEFAYTASISVGEKCV 120
Cdd:PHA03098   7 QKFCDESIIIVNGGgiIK----VHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  121 IHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLV 200
Cdd:PHA03098  79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  201 SRDELNVRCESEVFHACINWVKYDCENRRPYIQALLRAVRCHSLTPNFLQlQLQRCEILKGDS------RCqdYLSQIFQ 274
Cdd:PHA03098 159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKKKkivfnkRC--IKIIYSK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  275 DLTLHKPTLplqgRIPNVPQFIYVAGGYYRQSLSFLEAYNPVDgEWLTLASleMPRSGLAGCV-LGGLFYAVGGRNNAPD 353
Cdd:PHA03098 236 KYNLNKILP----RSSTFGSIIYIHITMSIFTYNYITNYSPLS-EINTIID--IHYVYCFGSVvLNNVIYFIGGMNKNNL 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  354 CNKDSGAldcYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGV 433
Cdd:PHA03098 309 SVNSVVS---YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCV 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  434 AVLNRLLYAVGG-FDGTNRLNSAECYYPETDEWKDIASMNIVRSGAGACALDTSVYAMGGYDGTDQ---LNSVERYDVEK 509
Cdd:PHA03098 386 VNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNikvYNIVESYNPVT 465

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 51703369  510 DDWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWT 560
Cdd:PHA03098 466 NKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
318-575 2.57e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 194.22  E-value: 2.57e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 318 GEWLTLASLEMPRSGLAGCVLGGLFYAVGGRNNapdcNKDSGALDCYNPMNNQWSPCAAMS-VPRNRVGAGVIDGQIYAV 396
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG----GSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 397 GGSHGCLHH----NSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETDEWKDIASMN 472
Cdd:COG3055  77 GGFTGANPSstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 473 IVRSG-AGACALDTSVYAMGGYDGTDQLNSverydvekddWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGstFLDGVEC 551
Cdd:COG3055 157 TPRDHlAAAVLPDGKILVIGGRNGSGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                       250       260
                ....*....|....*....|....
gi 51703369 552 YNPATDTWTEVTQMTSGRSGVGVA 575
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAV 248
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 152-254 2.85e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 136.52  E-value: 2.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369   152 AIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENRRPY 231
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 51703369   232 IQALLRAVRCHSLTPNFLQLQLQ 254
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 152-250 3.34e-34

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 125.15  E-value: 3.34e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369    152 AIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENRRPY 231
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 51703369    232 IQALLRAVRCHSLTPNFLQ 250
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 36-147 3.51e-31

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 116.97  E-value: 3.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369    36 MNELRLGQQLCDVKLKVKynDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASIsV 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVG--DK--EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-I 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 51703369   116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQL 147
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 47-147 3.04e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 100.07  E-value: 3.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369     47 DVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNG 126
Cdd:smart00225   1 DVTLVVGGK----KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 51703369    127 AVMYQMDSVVKACCDFLIQQL 147
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
439-484 3.89e-16

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 72.21  E-value: 3.89e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 51703369    439 LLYAVGGFDGTNRLNSAECYYPETDEWKDIASMNIVRSGAGACALD 484
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 521-566 1.18e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 65.33  E-value: 1.18e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 51703369   521 RRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMT 566
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-148 6.33e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 253.07  E-value: 6.33e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRL 104
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLD 148
Cdd:cd18248  81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 146-236 2.21e-61

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 198.29  E-value: 2.21e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 51703369 226 ENRRPYIQALL 236
Cdd:cd18458  81 ENRRQYLEALL 91
PHA03098 PHA03098
kelch-like protein; Provisional
 43-560 6.27e-61

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 211.55  E-value: 6.27e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369   43 QQLCDVKLKVKYND--VQdefvAHKIVLASSSPVFRAMFTNGLREcgmETVTIEGVHpKVMQRLLEFAYTASISVGEKCV 120
Cdd:PHA03098   7 QKFCDESIIIVNGGgiIK----VHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  121 IHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLV 200
Cdd:PHA03098  79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  201 SRDELNVRCESEVFHACINWVKYDCENRRPYIQALLRAVRCHSLTPNFLQlQLQRCEILKGDS------RCqdYLSQIFQ 274
Cdd:PHA03098 159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKKKkivfnkRC--IKIIYSK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  275 DLTLHKPTLplqgRIPNVPQFIYVAGGYYRQSLSFLEAYNPVDgEWLTLASleMPRSGLAGCV-LGGLFYAVGGRNNAPD 353
Cdd:PHA03098 236 KYNLNKILP----RSSTFGSIIYIHITMSIFTYNYITNYSPLS-EINTIID--IHYVYCFGSVvLNNVIYFIGGMNKNNL 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  354 CNKDSGAldcYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGV 433
Cdd:PHA03098 309 SVNSVVS---YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCV 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  434 AVLNRLLYAVGG-FDGTNRLNSAECYYPETDEWKDIASMNIVRSGAGACALDTSVYAMGGYDGTDQ---LNSVERYDVEK 509
Cdd:PHA03098 386 VNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNikvYNIVESYNPVT 465

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 51703369  510 DDWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWT 560
Cdd:PHA03098 466 NKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
318-575 2.57e-57

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 194.22  E-value: 2.57e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 318 GEWLTLASLEMPRSGLAGCVLGGLFYAVGGRNNapdcNKDSGALDCYNPMNNQWSPCAAMS-VPRNRVGAGVIDGQIYAV 396
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG----GSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 397 GGSHGCLHH----NSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETDEWKDIASMN 472
Cdd:COG3055  77 GGFTGANPSstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 473 IVRSG-AGACALDTSVYAMGGYDGTDQLNSverydvekddWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGstFLDGVEC 551
Cdd:COG3055 157 TPRDHlAAAVLPDGKILVIGGRNGSGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                       250       260
                ....*....|....*....|....
gi 51703369 552 YNPATDTWTEVTQMTSGRSGVGVA 575
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
296-539 1.41e-50

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 176.11  E-value: 1.41e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 296 IYVAGGY-YRQSLSFLEAYNPVDGEWLTLASLEMPRSGLAGCVL-GGLFYAVGGRNNAPDCNKDSGALDCYNPMNNQWSP 373
Cdd:COG3055  25 VYVAGGLsGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 374 CAAMSVPRNRVGAGVIDGQIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGVAVL-NRLLYAVGGFDGTNrl 452
Cdd:COG3055 105 LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSG-- 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 453 nsaecyypETDEWKDIASMNIVRSGAGACALDTSVYAMGGYDGTdqLNSVERYDVEKDDWTFVAPMRHRRSALGVTVHQG 532
Cdd:COG3055 183 --------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252


                ....*..
gi 51703369 533 KIYVLGG 539
Cdd:COG3055 253 KVYVIGG 259
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 152-254 2.85e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 136.52  E-value: 2.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369   152 AIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENRRPY 231
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 51703369   232 IQALLRAVRCHSLTPNFLQLQLQ 254
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
417-576 2.54e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 139.91  E-value: 2.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 417 EWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETDEWKDIASMNIV-RSGAGACALDTSVYAMGGYDG 495
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 496 TDQ----LNSVERYDVEKDDWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMTSGRSG 571
Cdd:COG3055  82 ANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161


                ....*
gi 51703369 572 VGVAI 576
Cdd:COG3055 162 LAAAV 166
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-154 1.31e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 127.02  E-value: 1.31e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  32 AFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTA 111
Cdd:cd18238   2 SFKVLHQFYENGELCDVTLKVG----EKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 51703369 112 SISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18238  78 KLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 152-250 3.34e-34

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 125.15  E-value: 3.34e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369    152 AIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENRRPY 231
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 51703369    232 IQALLRAVRCHSLTPNFLQ 250
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-154 1.64e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 124.44  E-value: 1.64e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISV 115
Cdd:cd18256  11 LNKLRGQHEFCDVQLQVG----MELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 51703369 116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18256  87 TVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 147-249 3.24e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 122.80  E-value: 3.24e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18457   1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                        90       100
                ....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18457  81 NREEYLPELLSKVRLPLLRPQFL 103
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 147-260 1.14e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 121.57  E-value: 1.14e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18445   1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFLQLQLQRCEILK 260
Cdd:cd18445  81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 1.20e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 121.78  E-value: 1.20e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVE----GKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDF 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18242  80 VYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-146 1.45e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 121.23  E-value: 1.45e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18247   1 DLPSSGFPVMEEIRRQGKLCDVTLKVG----DQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALIN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQ 146
Cdd:cd18247  77 FAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-149 6.61e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 119.45  E-value: 6.61e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVkyNDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18235   3 QHTQKAFDVMNELRKQNLLCDVILVA--DGV--EIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLID 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18235  79 YVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 36-147 3.51e-31

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 116.97  E-value: 3.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369    36 MNELRLGQQLCDVKLKVKynDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASIsV 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVG--DK--EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-I 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 51703369   116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQL 147
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-151 1.42e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 115.89  E-value: 1.42e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  31 QAFQIMNELRLGQQLCDVKLKVkyNDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYT 110
Cdd:cd18240   3 MACNVFNELRLEGKLCDVVIRV--NGV--EFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYT 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 51703369 111 ASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18240  79 RTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-154 8.09e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 114.12  E-value: 8.09e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  33 FQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTAS 112
Cdd:cd18237   9 MGVMNNMRKQKTLCDVILIVE----GREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTAR 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18237  85 ISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 146-249 1.26e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 109.73  E-value: 1.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18444   1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                        90       100
                ....*....|....*....|....
gi 51703369 226 ENRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18444  81 PERKKHLAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 3.07e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 106.32  E-value: 3.07e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVkynDVQdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIA---DGQ-RFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDF 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18255  77 AYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-154 3.58e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 106.38  E-value: 3.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  23 YSLADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQ 102
Cdd:cd18249   1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAME 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 51703369 103 RLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18249  77 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 147-249 5.63e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 106.33  E-value: 5.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                        90       100
                ....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18452  81 EREDYLPELLQYVRLPLLSPRYI 103
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.73e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 104.16  E-value: 1.73e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVkyNDVQdeFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRV--GDVK--IHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEY 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18257  77 AYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-153 1.84e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 103.60  E-value: 1.84e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  45 LCDVKLKVkyNDVQdeFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVM 124
Cdd:cd18234   1 LCDVILIA--GDRR--IPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76

                        90       100
                ....*....|....*....|....*....
gi 51703369 125 NGAVMYQMDSVVKACCDFLIQQLDPSNAI 153
Cdd:cd18234  77 ATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-152 2.05e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 104.08  E-value: 2.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISV 115
Cdd:cd18250  12 LSELRAERKFFDVTLCAG----GREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTV 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNA 152
Cdd:cd18250  88 TQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 148-249 2.19e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 103.26  E-value: 2.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 148 DPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCEN 227
Cdd:cd18468   1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                        90       100
                ....*....|....*....|..
gi 51703369 228 RRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18468  81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 147-240 5.67e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 102.33  E-value: 5.67e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                        90
                ....*....|....
gi 51703369 227 NRRPYIQALLRAVR 240
Cdd:cd18467  81 ERQKYLAQLLHCVR 94
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-155 5.73e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 103.11  E-value: 5.73e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVG----GHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNY 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18306  77 AYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-155 7.83e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 102.82  E-value: 7.83e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18336   1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIP----AHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVH 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18336  77 YAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.99e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 101.30  E-value: 1.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKynDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18338   4 HMKKAFKVMNELRSQNLLCDVTIVAE--DV--EIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18338  80 VYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 47-147 3.04e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 100.07  E-value: 3.04e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369     47 DVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNG 126
Cdd:smart00225   1 DVTLVVGGK----KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 51703369    127 AVMYQMDSVVKACCDFLIQQL 147
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 3.66e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 101.26  E-value: 3.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18246  22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIK----AHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQY 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18246  98 AYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 6.76e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 99.80  E-value: 6.76e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKynDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18339   4 HMKKAFKVMNELRSKQLLCDVTIVAE--DV--EIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18339  80 IYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-130 4.10e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 96.08  E-value: 4.10e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  45 LCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVM 124
Cdd:cd18186   1 LCDVTLVVGGR----EFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELL 76


                ....*.
gi 51703369 125 NGAVMY 130
Cdd:cd18186  77 AAADKL 82
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 146-240 5.46e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 96.34  E-value: 5.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                        90
                ....*....|....*
gi 51703369 226 ENRRPYIQALLRAVR 240
Cdd:cd18459  81 QERRPHLPQVLQHVR 95
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 146-249 1.34e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 95.52  E-value: 1.34e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18511   1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                        90       100
                ....*....|....*....|....
gi 51703369 226 ENRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18511  81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 148-224 2.12e-23

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 94.01  E-value: 2.12e-23
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51703369 148 DPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYD 224
Cdd:cd18508   1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 147-269 2.89e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 95.48  E-value: 2.89e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18512   1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFLQLQLQRCEILKGDSRCQDYL 269
Cdd:cd18512  81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYL 123
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 149-244 4.49e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 93.92  E-value: 4.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 149 PSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENR 228
Cdd:cd18455   2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                        90
                ....*....|....*.
gi 51703369 229 RPYIQALLRAVRCHSL 244
Cdd:cd18455  82 KVHLKDLMSSCWRSGL 97
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 146-240 7.89e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 93.14  E-value: 7.89e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18448   1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                        90
                ....*....|....*
gi 51703369 226 ENRRPYIQALLRAVR 240
Cdd:cd18448  81 QHRKRHLDDLLSQVR 95
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-155 5.53e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 92.19  E-value: 5.53e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  22 QYSLADHTNQAFQIMNELRLGQQLCDVKLKV----KYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVH 97
Cdd:cd18273   3 ELEDAAHARALLAQLKSFYDARLLTDVTIEVngpgSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVD 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 51703369  98 PKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18273  83 SESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 147-249 6.36e-22

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 90.62  E-value: 6.36e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18466   1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                        90       100
                ....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18466  81 KRKKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 147-269 6.38e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 91.67  E-value: 6.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18513   1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFLQLQLQRCEILKGDSRCQDYL 269
Cdd:cd18513  81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFL 123
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-155 8.00e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 91.28  E-value: 8.00e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18337   5 NHAEQTFKKMENYLRHKQLCDVVLVAGDRRIP----AHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18337  81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-155 1.38e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 90.62  E-value: 1.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18268   5 DLSSELLRQLNSLRQERILTDVILCTG----DKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18268  81 YVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-155 2.12e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 90.05  E-value: 2.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  44 QLCDVKLKVkynDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHV 123
Cdd:cd18274  21 QLTDIVVEV---DHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQAL 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 51703369 124 MNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18274  98 FTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 146-240 2.24e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 88.95  E-value: 2.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18447   1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                        90
                ....*....|....*
gi 51703369 226 ENRRPYIQALLRAVR 240
Cdd:cd18447  81 PNRQPYMVDILAKVR 95
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-154 8.83e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 88.37  E-value: 8.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVkynDVQdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISV 115
Cdd:cd18236  15 LENLRLENSLTDVILCV---DSQ-EFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLI 90

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 51703369 116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18236  91 TKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 147-249 3.15e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 86.23  E-value: 3.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18509   2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                        90       100
                ....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18509  82 RRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-155 3.20e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 86.64  E-value: 3.20e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18335   2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIP----AHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQF 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18335  78 AYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 147-248 3.64e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 85.82  E-value: 3.64e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                        90       100
                ....*....|....*....|..
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNF 248
Cdd:cd18456  81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 146-249 4.35e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 85.74  E-value: 4.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18510   1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                        90       100
                ....*....|....*....|....
gi 51703369 226 ENRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18510  81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-143 1.22e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 84.60  E-value: 1.22e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  42 GQQLCDVKLKVkyNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECG-METVTIEGVHPKVMQRLLEFAYTASISVGEKCV 120
Cdd:cd18294  11 NPEFSDVKFLV--GPERQEIFAHKCILAARCEVFRAMFLTGPQKEStQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTV 88

                        90       100
                ....*....|....*....|...
gi 51703369 121 IHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18294  89 IEVLAAAVEYGLDELRKLCERFI 111
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-232 5.63e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 82.21  E-value: 5.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80


                ....*.
gi 51703369 227 NRRPYI 232
Cdd:cd18483  81 KREMHL 86
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-154 7.86e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 82.75  E-value: 7.86e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  26 ADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTI-EGVHPKVMQRL 104
Cdd:cd18254   3 PSHPDCVLTHLNTLRKQCMFTDVTLWAG----NRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18254  79 LDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-240 1.20e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 81.31  E-value: 1.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18485   1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                        90
                ....*....|....
gi 51703369 227 NRRPYIQALLRAVR 240
Cdd:cd18485  81 SRVQHLVELLKQVR 94
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 1.31e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 81.81  E-value: 1.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVE----GREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQY 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18253  77 VYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-155 1.73e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 82.19  E-value: 1.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQ------LCDVKLKVKYND----VQD-EFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRL 104
Cdd:cd18340   3 VEELRLYQQtllqdgLKDLLDHNKFVDcvlkIKEkEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18340  83 LHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-139 1.79e-18

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 80.85  E-value: 1.79e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  43 QQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIH 122
Cdd:cd18314   4 SEFSDVVLCVGDR----KFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                        90
                ....*....|....*..
gi 51703369 123 VMNGAVMYQMDSVVKAC 139
Cdd:cd18314  80 LLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-154 3.44e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 80.97  E-value: 3.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKYNDvqdeFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18265   6 HAERILQVLNAYRRSGTFTDVVLLVDGKD----FPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18265  82 MYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-155 4.21e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 80.91  E-value: 4.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  34 QIMNELRLGQQ------LCDVKLKVKYND----VQD-EFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQ 102
Cdd:cd18269   1 EQKEELRLYQQtllqdgLKDLLDENKFVDcvlkIGDkEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 51703369 103 RLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18269  81 MILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-143 5.08e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 80.08  E-value: 5.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  34 QIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTI--EGVHPKVMQRLLEFAYTA 111
Cdd:cd18245   3 RALNSFREEPHLCDATLVVG----GEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIelEGISVEVMEEILDYIYTG 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 51703369 112 SISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18245  79 QIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 147-224 6.39e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 78.42  E-value: 6.39e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQ-EEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYD 224
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 146-223 9.02e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 78.20  E-value: 9.02e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51703369 146 QLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKY 223
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 147-240 1.61e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 77.96  E-value: 1.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18514   1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                        90
                ....*....|....
gi 51703369 227 NRRPYIQALLRAVR 240
Cdd:cd18514  81 KRKDYLPELLRNVR 94
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-151 1.98e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 78.71  E-value: 1.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  23 YSLADHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQ 102
Cdd:cd18251   1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIE----AHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMC 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 103 RLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18251  77 KILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-154 2.64e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 78.72  E-value: 2.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  21 FQYSLADHTNQAFQIMNELRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKV 100
Cdd:cd18259   8 LDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGR----EFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAV 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 51703369 101 MQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18259  84 MESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 145-245 3.36e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 77.49  E-value: 3.36e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 145 QQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYD 224
Cdd:cd18469   1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                        90       100
                ....*....|....*....|.
gi 51703369 225 CENRRPYIQALLRAVRCHSLT 245
Cdd:cd18469  81 PQARAAHLPELLSLVHLSLLT 101
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 147-246 7.90e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 75.93  E-value: 7.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELnVRCESEVFHACINWVKYDCE 226
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                        90       100
                ....*....|....*....|
gi 51703369 227 NRRPYIQALLRAVRCHSLTP 246
Cdd:cd18476  80 ARKGYIHDLFKKVRLQYVHP 99
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-153 2.33e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 75.99  E-value: 2.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  39 LRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEK 118
Cdd:cd18264  22 LRAEGFLCDVVLEAEGN----EFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLD 97

                        90       100       110
                ....*....|....*....|....*....|....*
gi 51703369 119 CVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAI 153
Cdd:cd18264  98 TLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCC 132
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-155 3.51e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 75.25  E-value: 3.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvqDE-FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLL 105
Cdd:cd18271   6 CHGQQILSVLQNFREQNAFFDFNIIVK-----DEtIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 51703369 106 EFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18271  81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
Kelch smart00612
Kelch domain;
439-484 3.89e-16

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 72.21  E-value: 3.89e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 51703369    439 LLYAVGGFDGTNRLNSAECYYPETDEWKDIASMNIVRSGAGACALD 484
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch smart00612
Kelch domain;
392-437 7.48e-16

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 71.44  E-value: 7.48e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 51703369    392 QIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGVAVLN 437
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-153 9.15e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 74.27  E-value: 9.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRL---GQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRL 104
Cdd:cd18270   6 NTEYAVSLLEQLKFfyeQQLLTDIVLIVEGT----EFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQII 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAI 153
Cdd:cd18270  82 ITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-155 9.52e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 74.07  E-value: 9.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISV 115
Cdd:cd18276  12 LNRMKELAELTDVVLVAE----GEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18276  88 TNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-154 1.29e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 73.71  E-value: 1.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  61 FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACC 140
Cdd:cd18252  34 FHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACE 113

                        90
                ....*....|....
gi 51703369 141 DFLIQQLDPSNAIG 154
Cdd:cd18252 114 QFLVRHLDIDNCLG 127
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 1.54e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 72.98  E-value: 1.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18198   7 DHSSEILSGLNEQRTQGLLCDVVILVQ----GREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLE 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18198  83 FAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-151 4.61e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 72.14  E-value: 4.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  23 YSLADHTNQAFQIMNELRLGQQLCDVKLKVkyNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQ 102
Cdd:cd18239   1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVP--GDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLK 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 103 RLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18239  79 NIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-155 4.71e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 72.71  E-value: 4.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTI-EGVHPKVMQRLLE 106
Cdd:cd18267  23 YADSVLTHLNLLRQQRLFTDVLLHAG----NRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLLD 98

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGI 155
Cdd:cd18267  99 YAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-240 5.30e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 70.86  E-value: 5.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18479   1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                        90
                ....*....|....
gi 51703369 227 NRRPYIQALLRAVR 240
Cdd:cd18479  81 SRSQYLSSVLSQIR 94
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 147-240 6.48e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 70.92  E-value: 6.48e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18462   1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                        90
                ....*....|....
gi 51703369 227 NRRPYIQALLRAVR 240
Cdd:cd18462  81 KRIECAYDLLSSIK 94
Kelch smart00612
Kelch domain;
533-579 9.73e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 68.35  E-value: 9.73e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 51703369    533 KIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMTSGRSGVGVAITME 579
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 1.12e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 71.05  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVkyndvQDE-FVAHKIVLASSSPVFRAMFTNGLRECG------------METVTIE 94
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRV-----QDKiFRAHKVVLAACSDFFRSKLVGQASPRLvlvspagkcvldLHHVTVT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369  95 GVHPkvmqrLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18228  77 GFAP-----LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-151 2.22e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 70.31  E-value: 2.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  23 YSLADHTNQAFQIMNELRLGQQLCDVKLkvkyndVQDE--FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKV 100
Cdd:cd18266   3 YRWADHSNLVLQGLNEQRQRGLFCDVVL------VADEqrVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIG 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 51703369 101 MQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18266  77 LKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-143 2.98e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 69.69  E-value: 2.98e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  22 QYSLADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTngLREcgMETVTIEGV-HPKV 100
Cdd:cd18222   2 QLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQ----GQSFRAHKVVLAASSPYFRDHMS--LNE--MSTVSISVIkNPTV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 51703369 101 MQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18222  74 FEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 4.83e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 68.81  E-value: 4.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18326   7 DHSSDILSSLNEQRTQGLLCDVVILVE----GREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLD 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18326  83 FAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 46-149 4.90e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 68.69  E-value: 4.90e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  46 CDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMN 125
Cdd:cd18263  14 CDVQLEAD----GSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATC 89

                        90       100
                ....*....|....*....|....
gi 51703369 126 GAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18263  90 TALQLQISGALALCLDFLQREISP 113
Kelch smart00612
Kelch domain;
487-532 6.40e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.04  E-value: 6.40e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 51703369    487 VYAMGGYDGTDQLNSVERYDVEKDDWTFVAPMRHRRSALGVTVHQG 532
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 7.33e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 68.84  E-value: 7.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18261  11 HKDAVLAALNQQRNDGILCDITLVAE----EQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDF 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18261  87 AYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 8.48e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 67.98  E-value: 8.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQ----DQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILE 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18328  83 FAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 147-249 1.05e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 67.49  E-value: 1.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                        90       100
                ....*....|....*....|...
gi 51703369 227 NRRPYIQALLRAVRCHSLTPNFL 249
Cdd:cd18446  81 ERLPLLPRVLENVRLPLLDPWYF 103
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 521-566 1.18e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 65.33  E-value: 1.18e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 51703369   521 RRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMT 566
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 1.61e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 67.56  E-value: 1.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETV-------TIEGVHPK 99
Cdd:cd18327   7 EHSSELLSCLNEQRRAGLLCDLTIKTR----GLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPE 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 100 VMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18327  83 ALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-113 1.71e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 67.35  E-value: 1.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  41 LGQQL---------CDVKLkvkynDVQDE-FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYT 110
Cdd:cd18280   1 LGQHFgalleseegADVTF-----NVDGEkFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75


                ...
gi 51703369 111 ASI 113
Cdd:cd18280  76 DEL 78
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 148-202 1.86e-13

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 64.99  E-value: 1.86e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 51703369 148 DPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSR 202
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-117 2.35e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 67.19  E-value: 2.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNG-LRECGMETVTIEGVHPKVMQRLLEFAYTASIS 114
Cdd:cd18211  16 MHKLRLLGHLCDVTVQVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFASFLEFVYTAKVE 95


                ...
gi 51703369 115 VGE 117
Cdd:cd18211  96 VEE 98
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 149-240 2.56e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 65.98  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 149 PSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENR 228
Cdd:cd18464   2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                        90
                ....*....|..
gi 51703369 229 RPYIQALLRAVR 240
Cdd:cd18464  82 HEVLPELLRSVR 93
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 147-245 2.69e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 66.02  E-value: 2.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                        90
                ....*....|....*....
gi 51703369 227 NRRPYIQALLRAVRCHSLT 245
Cdd:cd18477  81 NRQKALPTVFESIRFRLLP 99
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
296-399 3.61e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.18  E-value: 3.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 296 IYVAGGYYRQS-LSFLEAYNPVDGEWLTLASLEMPRSGLAG-CVLGGLFYAVGGRNNAPDCNK----------------- 356
Cdd:COG3055 124 IYVVGGWDDGGnVAWVEVYDPATGTWTQLAPLPTPRDHLAAaVLPDGKILVIGGRNGSGFSNTwttlaplptaraghaaa 203

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 51703369 357 -----------DSGALD---CYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGGS 399
Cdd:COG3055 204 vlggkilvfggESGFSDeveAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGE 260
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 5.72e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 65.59  E-value: 5.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKynDVQdeFVAHKIVLASSSPVFRAMFTNGlRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIVE--NVQ--FRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEF 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18212  81 IYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-151 6.26e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 65.92  E-value: 6.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  32 AFQIMNELrlgqqLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMEtVTIEGVHPKVMQRLLEFAYTA 111
Cdd:cd18281  14 AFLFNNET-----LSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSD 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 112 SISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18281  88 EVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 427-472 7.19e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.01  E-value: 7.19e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 51703369   427 RRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETDEWKDIASMN 472
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 475-519 8.41e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.01  E-value: 8.41e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 51703369   475 RSGAGACALDTSVYAMGGYDGTDQLNSVERYDVEKDDWTFVAPMR 519
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PLN02193 PLN02193
nitrile-specifier protein
 429-562 9.10e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 70.75  E-value: 9.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  429 IGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPETDEWKDIASMN---IVRSGAGACALDTSVYAMGGYDGTDQLNSVERY 505
Cdd:PLN02193 220 LGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSY 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51703369  506 DVEKDDW--------TFVApmrhrRSALGVTVHQGKIYVLGGYDGSTfLDGVECYNPATDTWTEV 562
Cdd:PLN02193 300 NIVDKKWfhcstpgdSFSI-----RGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQV 358
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 9.26e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 64.95  E-value: 9.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18287   4 DHVHFLSEDIGALFLNEEYSDVTFVVE----EKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLK 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 107 FAYTASISVG---EKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18287  80 YIYTGRLTLTdlkEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-143 1.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 65.05  E-value: 1.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  22 QYSLADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLREcGMETVTIEgvHPKVM 101
Cdd:cd18220   2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQ----GQPFRAHKAVLAASSPYFRDHSALSTMS-GLSISVIK--NPNVF 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 102 QRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18220  75 EQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-153 1.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 64.83  E-value: 1.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTnglRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATK----TKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITY 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAI 153
Cdd:cd18260  74 AYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 150-241 1.23e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 64.01  E-value: 1.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 150 SNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENRR 229
Cdd:cd18516   4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                        90
                ....*....|..
gi 51703369 230 PYIQALLRAVRC 241
Cdd:cd18516  84 KALPVLLESIRF 95
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-145 1.40e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 64.99  E-value: 1.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  21 FQYSLADHTNQAFQIMNELRL-GQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTN------GLRECGMETVTi 93
Cdd:cd18207   2 YTYQVSQHSADMLHNLNQQRKsGGRFCDVLLRVG----EESFPAHRAVLAACSEYFESVFSAqegdggTPRELEMHTIS- 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 51703369  94 egvhPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQ 145
Cdd:cd18207  77 ----SKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 1.63e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 64.49  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLReCGMETVTIE-GVHPKVMQRLLE 106
Cdd:cd18331   7 HASDVLLNLNRLRSRDILTDVVIVVS----REQFRAHKTVLMACSGLFYSIFTDQLK-CNLSVINLDpEINPEGFNILLD 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18331  82 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 147-240 1.99e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 63.66  E-value: 1.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....
gi 51703369 227 NRRPYIQALLRAVR 240
Cdd:cd18460  81 HRQHFWPELLQHVR 94
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 380-425 2.17e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 61.86  E-value: 2.17e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 51703369   380 PRNRVGAGVIDGQIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMK 425
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 149-240 2.18e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 63.46  E-value: 2.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 149 PSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCENR 228
Cdd:cd18515   2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                        90
                ....*....|..
gi 51703369 229 RPYIQALLRAVR 240
Cdd:cd18515  82 HCYLSELLQTVR 93
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-150 3.04e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 63.93  E-value: 3.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVT-IEGVHPKVMQR 103
Cdd:cd18230   1 ITSHYRHLLRELNEQRQHGILCDVCIIVE----GKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKA 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 51703369 104 LLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPS 150
Cdd:cd18230  77 IIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-147 3.38e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 64.21  E-value: 3.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  33 FQIMNELRLgqqLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTAS 112
Cdd:cd18244  21 FRALYEEGL---LLDVTLVIE----DHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGT 93

                        90       100       110
                ....*....|....*....|....*....|....*
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQL 147
Cdd:cd18244  94 IELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKI 128
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 3.94e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 63.53  E-value: 3.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTI--EGVHPKVMQRLL 105
Cdd:cd18196   4 HFEQIFQQLNYQRLHGQLCDCVIVVG----NRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLdsEVVTAEAFAALI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 106 EFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18196  80 DMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-228 5.82e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 61.57  E-value: 5.82e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18480   1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                ..
gi 51703369 227 NR 228
Cdd:cd18480  81 AR 82
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 147-228 8.46e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 61.71  E-value: 8.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80


                ..
gi 51703369 227 NR 228
Cdd:cd18517  81 NR 82
PHA02790 PHA02790
Kelch-like protein; Provisional
 107-559 9.53e-12

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 67.38  E-value: 9.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVaKQE 186
Cdd:PHA02790  80 YSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL-EDD 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  187 EFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKydceNRRPYIQALL----RAVRCHSLTP---NFLQLQLQRCEIL 259
Cdd:PHA02790 159 IIDNFDYLSMKLILESDELNVPDEDYVVDFVIKWYM----KRRNRLGNLLllikNVIRSNYLSPrgiNNVKWILDCTKIF 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  260 KGDSRCQDYLSQIFQDLTLhkptlplqgripNVPQFIYVaggyyrqslsfleaynpvdgewltlasLEMPRSGLAGCVLg 339
Cdd:PHA02790 235 HCDKQPRKSYKYPFIEYPM------------NMDQIIDI---------------------------FHMCTSTHVGEVV- 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  340 glfYAVGGRNNApDCNKDSGALDCynpMNNQWSPCAAMSVPRNRVGAGVIDGQIYAVGGshgCLHHNSVERYDPERDEWH 419
Cdd:PHA02790 275 ---YLIGGWMNN-EIHNNAIAVNY---ISNNWIPIPPMNSPRLYASGVPANNKLYVVGG---LPNPTSVERWFHGDAAWV 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  420 MVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNrlNSAECYYPETDEWKDIASMNIVRSGAGACALDTSVYAMGgydgtdql 499
Cdd:PHA02790 345 NMPSLLKPRCNPAVASINNVIYVIGGHSETD--TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG-------- 414

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  500 NSVERYDVEKDDWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTW 559
Cdd:PHA02790 415 RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-155 9.69e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 62.56  E-value: 9.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  61 FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACC 140
Cdd:cd18341  39 LPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCV 118

                        90
                ....*....|....*
gi 51703369 141 DFLIQQLDPSNAIGI 155
Cdd:cd18341 119 TYLQKRLSPANCLAI 133
PHA02713 PHA02713
hypothetical protein; Provisional
 378-537 1.20e-11

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 67.34  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  378 SVPRNRV--GAGVIDGQIYAVGG-SHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTNRLNS 454
Cdd:PHA02713 289 TIPNHIInyASAIVDNEIIIAGGyNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERT 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  455 AECYYPETDEWKDIASMNIVRSGAGACALDTSVYAMGGY------------------DGTDQLNSVERYDVEKDDWTFVA 516
Cdd:PHA02713 369 IECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRtehidytsvhhmnsidmeEDTHSSNKVIRYDTVNNIWETLP 448

                        170       180
                 ....*....|....*....|.
gi 51703369  517 PMRHRRSALGVTVHQGKIYVL 537
Cdd:PHA02713 449 NFWTGTIRPGVVSHKDDIYVV 469
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-143 1.33e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 61.86  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQ-QLCDVKLKVKYNdvQDEFVAHKIVLASSSPVFRAMFTNGLR----ECGMETVTIEGvhpkvMQRLLEFAYT 110
Cdd:cd18231   4 LNEQRLFQpDLCDVDIVLVRQ--RSTFPAHKGVLAAYSQFFHSLFTQNKQlqrvELSLEALTSQG-----LQQILNFIYT 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 51703369 111 ASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18231  77 SKLLVNSCNVQDVLNAAAVLQMNDIAASCQELI 109
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 45-144 2.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 59.87  E-value: 2.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  45 LCDVKLKVkyndvQDEFV-AHKIVLASSSPVFRAMFTNgLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKcvihv 123
Cdd:cd18315   1 LVDVTLAC-----EGGSLkAHKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQE----- 69

                        90       100
                ....*....|....*....|.
gi 51703369 124 mngavmyQMDSVVKACCDFLI 144
Cdd:cd18315  70 -------QLESLLKLAELLQI 83
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-151 6.39e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 59.98  E-value: 6.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  61 FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASIS---VGEKCVIHVMNGAVMYQMDSVVK 137
Cdd:cd18297  24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDALELLRAASFFQLDGLKR 103

                        90
                ....*....|....
gi 51703369 138 ACCDFLIQQLDPSN 151
Cdd:cd18297 104 HCEILLSQQIDLDN 117
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-143 6.84e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 6.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVKyNDVqdeFVAHKIVLASSSPVFRAMFTNGLRECGMETV-TIEGVHPKVMQR 103
Cdd:cd18329   1 ISSHQSRLLQQLDEQRKQELFCDCSILVE-GQV---FKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 104 LLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18329  77 ILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 57-147 9.53e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 59.18  E-value: 9.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  57 VQDEFV-AHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGE--KCViHVMNGAVMYQMD 133
Cdd:cd18300  16 VEDGTIpAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEdgDCV-GLIVLANRLCLP 94

                        90
                ....*....|....
gi 51703369 134 SVVKACCDFLIQQL 147
Cdd:cd18300  95 RLVALCEQYIVKEL 108
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 147-227 9.68e-11

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 58.79  E-value: 9.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQL-VNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIeVILESNQELESINERKLCQLVLEWVQRSI 80


                ..
gi 51703369 226 EN 227
Cdd:cd18502  81 EE 82
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 1.87e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 58.33  E-value: 1.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVG----GTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDF 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18332  78 MYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-147 2.49e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 58.31  E-value: 2.49e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  60 EFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18279  29 EFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMC 108


                ....*...
gi 51703369 140 CDFLIQQL 147
Cdd:cd18279 109 EDALCSNL 116
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-154 3.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 58.06  E-value: 3.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMET---VTIEGVHPKVMQRLLEFAYTAS 112
Cdd:cd18258   8 LNQQRRAKEFTDLKIIVE----GKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYTGS 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAIG 154
Cdd:cd18258  84 LIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-151 4.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 57.71  E-value: 4.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  38 ELRLGQQLCDVKLKVKYNDVQ-----DEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTAS 112
Cdd:cd18343   5 ECRLAEDLGNLWENSRFTDCSlfvggQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18343  85 APNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-145 5.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 57.35  E-value: 5.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  19 RQFQYSLADHTNQAFQIMNELRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGlrecgmETVTIE---G 95
Cdd:cd18290   1 QTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGH----AFKAHRAVLAASSSYFRDLFNSS------RSAVVElpaA 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 51703369  96 VHPKVMQRLLEFAYTA--SISVGEKCVIhvMNGAVMYQMDSVVKACCDFLIQ 145
Cdd:cd18290  71 VQPQSFQQILSFCYTGrlSMNVGDQFLL--MYTAGFLQIQEIMEKGTEFFLK 120
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-152 6.64e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 57.27  E-value: 6.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  60 EFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASI----SVGEKCviHVMNGAVMYQMDSV 135
Cdd:cd18344  34 EFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAphlhSHSMAC--DVLAAADKYGLEGL 111

                        90
                ....*....|....*..
gi 51703369 136 VKACCDFLIQQLDPSNA 152
Cdd:cd18344 112 KVLCEDALCRNLSVENA 128
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-142 9.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.53  E-value: 9.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  43 QQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVtIEGVHP----KVMQRLLEFAYTASISVGEK 118
Cdd:cd18292  15 EELSDIVLRVG----GKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSE-IELVEDpecaAVFEKFLRYLYTGQISVNLE 89

                        90       100
                ....*....|....*....|....
gi 51703369 119 CVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18292  90 TALPLLMLADKYNVTDLKQLCVDF 113
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 147-242 1.04e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 55.97  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGE-VAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDC 225
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                        90
                ....*....|....*..
gi 51703369 226 ENRRPYIQALLRAVRCH 242
Cdd:cd18482  81 KERAASAAEVLKCVRWQ 97
Kelch smart00612
Kelch domain;
343-391 1.48e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 53.72  E-value: 1.48e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 51703369    343 YAVGGRNNAPDCNKdsgaLDCYNPMNNQWSPCAAMSVPRNRVGAGVIDG 391
Cdd:smart00612   3 YVVGGFDGGQRLKS----VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 147-224 1.55e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 54.82  E-value: 1.55e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYD 224
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 1.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 55.33  E-value: 1.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLREcgmETVTIEGVHPKVMQRLLEF 107
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVG----SQEFPAHSLVLAGASQQLGRQLTNPNPG---QWCLGEGISPSTFKQLLDF 73

                        90       100       110
                ....*....|....*....|....*....|..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18218  74 VYGESVEVQPGELRPLLEAARALEVESLEEAC 105
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-147 1.90e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 55.48  E-value: 1.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  37 NELrlgqqLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMEtVTIEGVHPKVMQRLLEFAYTASISVG 116
Cdd:cd18282   4 NEL-----MADVHFIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLE 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 51703369 117 EKCVIHVMNGAVMYQMDSVVKACCDFLIQQL 147
Cdd:cd18282  78 PDTVLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-152 1.90e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 55.62  E-value: 1.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  38 ELRLGQQLCDVKLKVKYNDVQ-----DEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTAS 112
Cdd:cd18345   2 ECRLSDDLGLLFERSAFSDVTlcvggREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNA 152
Cdd:cd18345  82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-143 2.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 55.33  E-value: 2.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  21 FQYSLADHTNQAFQIMNELRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVF--RAMFTNGLRecgmeTVTIEGVHP 98
Cdd:cd18227   1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGH----LFRAHKAVLAASSPYFcdQVLLKNSRR-----IVLPDVMNP 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 51703369  99 KVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18227  72 RVFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-142 3.17e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 54.42  E-value: 3.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  46 CDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGME---TVTIEGVHPKVMQRLLEFAYTASISVGEKCVIH 122
Cdd:cd18307   2 CDVVISVD----NHSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVED 77

                        90       100
                ....*....|....*....|
gi 51703369 123 VMNGAVMYQMDSVVKACCDF 142
Cdd:cd18307  78 LLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 4.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 54.35  E-value: 4.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyNDVqdeFVAHKIVLASSSPVFRAMFTNGLRECGMETV-TIEGVHPKVMQRLLE 106
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVE-GRI---FKAHRNVLFASSGYFRMLLSHYIQDTGRPSTaSFDVFSSDAFSIILD 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18199  77 FVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-151 4.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 55.06  E-value: 4.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  63 AHKIVLASSSPVFRAMFTNGLRECGMEtVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18346  46 AHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 124


                ....*....
gi 51703369 143 LIQQLDPSN 151
Cdd:cd18346 125 LTKHLRADN 133
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 54-148 4.67e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 54.61  E-value: 4.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  54 YNDVQDE-----FVAHKIVLASSSPVFRAMFTNGLREC-----GMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHV 123
Cdd:cd18296  17 FPDVCFQveghrFPCHKAFFCGRSDYFKALLRDHFAESeenngSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                        90       100
                ....*....|....*....|....*
gi 51703369 124 MNGAVMYQMDSVVKACCDFLIQQLD 148
Cdd:cd18296  97 LYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 61-146 4.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 54.41  E-value: 4.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  61 FVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSvVKACC 140
Cdd:cd18352  25 FYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEG-LKRLC 103


                ....*.
gi 51703369 141 DFLIQQ 146
Cdd:cd18352 104 EYTIAQ 109
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-152 4.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 54.72  E-value: 4.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  38 ELRLGQQLCDVKLKVKYND-----VQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTAS 112
Cdd:cd18342   6 ECRLADELGGLWENSRFTDcclcvAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGK 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNA 152
Cdd:cd18342  86 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-138 4.99e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 54.24  E-value: 4.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLREcgmETVTIEGVHPKVMQRLLEFAYTASISV 115
Cdd:cd18221   9 LNEQRELDQFTDITLIVDGH----QFKAHKAVLAACSQFFYKFFQDFTQE---PLVEIEGVSNMAFRHLIEFTYTAKLMV 81

                        90       100
                ....*....|....*....|....
gi 51703369 116 -GEKCVIHVMNGAVMYQMDSVVKA 138
Cdd:cd18221  82 qGEEEANDVWKAAEYLQMQEAIKA 105
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-135 6.04e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 54.19  E-value: 6.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  38 ELRLGQQLCDVKLKVKYNDVqdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGE 117
Cdd:cd18286   8 LLQLFLNGEDSDITIKVDGK--TFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPD 85

                        90
                ....*....|....*....
gi 51703369 118 KC-VIHVMNGAVMYQMDSV 135
Cdd:cd18286  86 DVnLGELLSLADMYGLDGL 104
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 7.37e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 53.72  E-value: 7.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLREcGMETVTIEG-VHPKVMQRLLE 106
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVG----REQFRAHKTVLMACSGLFYSIFTDQLKN-NVSVINLDPeIEPEGFRILLD 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18215  77 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTC 109
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 7.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 53.78  E-value: 7.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKYNDvqdeFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGvhpkvMQRLLEF 107
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVD----FKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAAG-----LGQVLEF 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18206  76 MYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 147-221 1.14e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 52.00  E-value: 1.14e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWV 221
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-151 1.19e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 53.54  E-value: 1.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  32 AFQIMNELrlgqqLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMEtVTIEGVHPKVMQRLLEFAYTA 111
Cdd:cd18347  14 AFLFNNEV-----LSDVHFLVGKGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSD 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 112 SISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18347  88 EVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-155 1.21e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 54.13  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  60 EFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18272  43 EFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEEC 122

                        90
                ....*....|....*.
gi 51703369 140 CDFLIQQLDPSNAIGI 155
Cdd:cd18272 123 SRFLARTVQVRNCLQV 138
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-149 1.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 53.50  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  30 NQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFtNGLRECGMETVTieGVHPKVMQRLLEFAY 109
Cdd:cd18289  14 NTVLGCLNEQRLMGLYCDVSIVVK----GQAFKAHRAVLAASSLYFRDLF-SGNSKSAFELPA--TVPPACFQQILSFCY 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 51703369 110 TASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18289  87 TGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-145 1.79e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 52.55  E-value: 1.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  29 TNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVtiegVHPKVMQRLLEFA 108
Cdd:cd18229   2 SKSLLETLNAQRLGGHFCDVTVRIHDASLR----AHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFM 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51703369 109 YTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQ 145
Cdd:cd18229  74 YSGSLVVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 2.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 52.45  E-value: 2.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFtnglRECGMETVTI--EGVHPKVMQRLL 105
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIG----QFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKLL 72

                        90       100       110
                ....*....|....*....|....*....|....
gi 51703369 106 EFAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18217  73 EFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-149 2.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 52.52  E-value: 2.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  22 QYSLADHTNQAFQIMNELRLGQQLCDVklKVKYNDVqdEFVAHKIVLASSSPVFRAMFTngLRECGMETVTIEGvHPKVM 101
Cdd:cd18214   2 HFRFENYGDSMLQKMNKLREQNKFCDV--TVHIDDL--EVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQ-NSEVG 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 51703369 102 QRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18214  75 RQLLLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-149 3.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 52.19  E-value: 3.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  22 QYSLADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTngLRECGMETVTIegVH-PKV 100
Cdd:cd18203   2 RFQLPGHEAATLRNMNQLRSEERFCDVTIVAD----SLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSL--MHsSRV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 51703369 101 MQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDP 149
Cdd:cd18203  74 VADLLLSCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-112 3.95e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 51.13  E-value: 3.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  34 QIMNELRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAMFTNGLRECGM----ETVTIEGVHPKVMQRLLEFAY 109
Cdd:cd18301   7 KLLDEADEGDNIHDVVFQVGGK----TFPAHKFILASRSDYFRKLFLSSLLTSEDavgcDVVHIEKVPPEIFEQLLQFIY 82


                ...
gi 51703369 110 TAS 112
Cdd:cd18301  83 TDT 85
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-139 3.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 52.14  E-value: 3.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18323   5 DHSRHLLQSLREQRHQGFLCDCTVLVG----STQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLE 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18323  81 FMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC 113
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-139 5.02e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 51.78  E-value: 5.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFT-NGLRECGMETVTIEGVHPKVMQRLLEFAYTASIS 114
Cdd:cd18202  10 LNQQRLNNQFCDVTLLIE----GEEYKAHKSVLAANSEYFRELFIeKGAVSSHEAVVDLSGFCKSSFLPLLEFAYTSELT 85

                        90       100
                ....*....|....*....|....*
gi 51703369 115 VGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18202  86 FDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 60-110 9.03e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 49.59  E-value: 9.03e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 51703369  60 EFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYT 110
Cdd:cd01165   9 KFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYG 59
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-110 1.04e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 50.29  E-value: 1.04e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51703369  36 MNELrLGQQLC-DVKLkvkYNDVQDEFVAHKIVLASSSPVFRAMFTNglrecgMETVTIEG-VHPKVMQRLLEFAYT 110
Cdd:cd18299   3 LRNL-LHSPSCaDVVF---ILQGGVRIFAHRIVLAAASSVFADLFLM------MTVVTLDSdITPEAFRRVLEFLYT 69
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-143 1.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 50.37  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  43 QQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLREcGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIH 122
Cdd:cd18349   6 ELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLAE-VKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLA 84

                        90       100
                ....*....|....*....|.
gi 51703369 123 VMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18349  85 TLYAAKKYIVPALAKACVNFL 105
Kelch smart00612
Kelch domain;
296-340 1.21e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 1.21e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 51703369    296 IYVAGGY-YRQSLSFLEAYNPVDGEWLTLASLEMPRSGLAGCVLGG 340
Cdd:smart00612   2 IYVVGGFdGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PLN02153 PLN02153
epithiospecifier protein
 380-562 1.34e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 53.84  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  380 PRNRVGAGVIDGQIYAVGGSHGCLHHNSVERY--DPERDEWHMVSPM----KTRRIGVGVAVLNRLLYAVGGFDGTNRLN 453
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGELKPNEHIDKDLYvfDFNTHTWSIAPANgdvpRISCLGVRMVAVGTKLYIFGGRDEKREFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  454 SAECYYPETDEWKDIASMNIV-----RSGAGACALDTSVYAMGGYD--GT----DQLNSVERYDVEKDDWTFVA-PMRH- 520
Cdd:PLN02153 102 DFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSkgGLmktpERFRTIEAYNIADGKWVQLPdPGENf 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 51703369  521 -RRSALGVTVHQGKIYVLGGYDGSTFLDG--------VECYNPATDTWTEV 562
Cdd:PLN02153 182 eKRGGAGFAVVQGKIWVVYGFATSILPGGksdyesnaVQFFDPASGKWTEV 232
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-148 1.43e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 50.34  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  31 QAFQIMNELRLGQQLCDVKLKVKYNdvqdEFVAHKIVLASSSPVFRAM--FTNGlRECGMETVT-IEGVHPKVMQRLLEF 107
Cdd:cd18201   7 QLLQELNEQRKKGILCDVNIVVSGK----VFRAHKNILVAGSRFFKTLycFTNK-ESCDQTTVThLDVVAVQGFSVILDF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLD 148
Cdd:cd18201  82 MYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-145 1.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 50.06  E-value: 1.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  24 SLADHTNQAFQIMNELRLGQQLCDVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVtiegVHPKVMQR 103
Cdd:cd18208   4 NLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLR----AHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQK 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 51703369 104 LLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQ 145
Cdd:cd18208  76 LIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-143 1.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 50.25  E-value: 1.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  33 FQIMNELRLGQQLCDVKLKVkyNDVqdEFVAHKIVLASSSPVFRAMFTngLRECGMETVTIEGvHPKVMQRLLEFAYTAS 112
Cdd:cd18197  13 LQKMNLLRQQNLFCDVSIYI--NDT--EFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQ-SAEVGRKLLLSCYTGA 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 51703369 113 ISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18197  86 LEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-143 1.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 49.39  E-value: 1.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  45 LCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFT----NGLRECGMETVTIEGVHPkvmqrLLEFAYTASISVGEKCV 120
Cdd:cd18955   1 LCDVTIVVE----DQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENV 71

                        90       100
                ....*....|....*....|...
gi 51703369 121 IHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18955  72 LEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-115 2.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 49.49  E-value: 2.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLREcGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVG----DQKFRAHKNVLAASSEYFQSLFTEKENE-SQSVFQLDFCEPDAFENVLNY 75


                ....*...
gi 51703369 108 AYTASISV 115
Cdd:cd18209  76 IYSSSLFV 83
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
296-351 3.19e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.08  E-value: 3.19e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 51703369 296 IYVAGGYYRQSLSfLEAYNPVDGEWLTLASLEMPRSGLAGCVLGGLFYAVGGRNNA 351
Cdd:COG3055 209 ILVFGGESGFSDE-VEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 329-378 3.51e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.84  E-value: 3.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 51703369   329 PRSGLAGCVLGGLFYAVGGRNNAPDCNKdsgaLDCYNPMNNQWSPCAAMS 378
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNS----VEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-143 3.87e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 49.07  E-value: 3.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTngLRecGMETVTIEGV-HPKVMQRLLEFAYTASIS 114
Cdd:cd18210  12 LNQQRMEGKLCDISIHVQ----GRVFRAHRAVLAASSPYFHDQVL--LK--NMSSISLPGVmDPGAFESVLASAYTGKLT 83

                        90       100
                ....*....|....*....|....*....
gi 51703369 115 VGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18210  84 MLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-139 4.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 49.06  E-value: 4.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  26 ADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNglreCGME---TVTIEGVHPKVMQ 102
Cdd:cd18224   7 SDHPNNLLKELNKCRLSETMCDVTIVVG----NRSFAAHKAVLACAAGYFQKLFLS----TELDvarTYVVDFITPANFE 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 51703369 103 RLLEFAYTASIsvgekcVIHVMNGAVMYQ------MDSVVKAC 139
Cdd:cd18224  79 KVLSFIYTSEL------FTDLINVGVIYEvaeklgMEDLLKAC 115
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-143 4.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 49.18  E-value: 4.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  21 FQYSLADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFT----NGLRECGMETVTIEGV 96
Cdd:cd18278   7 YVYESTVHCTNILLCLNDQRKQDILCDVTLIVE----GKEFRAHRAVLAACSEYFLQALVgqteNDLVVSLPEEVTARGF 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 51703369  97 HPkvmqrLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18278  83 GP-----LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-143 4.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 48.49  E-value: 4.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  37 NELRLGQQLCDVKLKVkynDVQdEFVAHKIVLASSSPVFRAMFTNGlrecgMETVTIEGVHPKVMQRLLEFAYTASISVG 116
Cdd:cd18205  10 NQMRLAGTLCDVVIMV---DSQ-EFHAHRTVLACTSKMFEILFHRN-----SQHYTLDFLSPKTFQQILEYAYTATLQAK 80

                        90       100
                ....*....|....*....|....*..
gi 51703369 117 EKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18205  81 VEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-139 6.24e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 48.38  E-value: 6.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGM-ETVTIEGVHPKVMQRLLEFAYTASIS 114
Cdd:cd18330   9 LNEQRKRDFFCDCSIIVE----GRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSEAFSIILDFLYSGKLD 84

                        90       100
                ....*....|....*....|....*
gi 51703369 115 VGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18330  85 LCSENVIEVMSAASYLQMTDVVNFC 109
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 8.15e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 48.11  E-value: 8.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKynDVQdeFVAHKIVLASSSPVFRAMFTNgLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVE--DVK--FRAHRCVLAACSTYFKKLFKK-LEVDSSSVIEIDFLRSDIFEEVLNY 75

                        90       100       110
                ....*....|....*....|....*....|..
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18204  76 MYTAKISVKKEDVNLMMSSGQILGIRFLDKLC 107
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-143 9.87e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 47.90  E-value: 9.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVkyNDVQdeFVAHKIVLASSSPVFRAMFTNglrecgMETVTIEG--VHPKVMQ 102
Cdd:cd18225   3 LPNYSRQLLQQLHTLRKEQQFCDCTIFI--GTFH--FRAHKLVLAASSLLFKSLLDS------TDTISIDAsvVSPEEFA 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 51703369 103 RLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18225  73 LLLEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
PRK14131 PRK14131
N-acetylneuraminate epimerase;
464-576 1.52e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.78  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  464 EWKDIASM-NIVRSGAGACALDTSVYAMGGY-----DGTDQL-NSVERYDVEKDDWTFVaPMRHRRSALG---VTVHQGK 533
Cdd:PRK14131  63 GWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNSWQKL-DTRSPVGLAGhvaVSLHNGK 141

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51703369  534 IYVLGGYDGSTFlDG-----------------------------------VECYNPATDTWTEVTQMT-SGRSGVGVAI 576
Cdd:PRK14131 142 AYITGGVNKNIF-DGyfedlaaagkdktpkdkindayfdkkpedyffnkeVLSYDPSTNQWKNAGESPfLGTAGSAVVI 219
Kelch_6 pfam13964
Kelch motif;
522-569 2.99e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 44.63  E-value: 2.99e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 51703369   522 RSALGVTVHQGKIYVLGGY-DGSTFLDGVECYNPATDTWTEVTQMTSGR 569
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-151 2.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 46.33  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  63 AHKIVLASSSPVFRAMFTNglrecgmETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18275  18 AHKSVLAAKSDYFRARLSR-------DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAVDA 90


                ....*....
gi 51703369 143 LIQQLDPSN 151
Cdd:cd18275  91 VRAQLCLGN 99
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-139 3.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 46.74  E-value: 3.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVkyNDVQdeFVAHKIVLASSSPVFRAMFTNglRECGMETVTIEG--VHPKVMQRL 104
Cdd:cd18194   5 EHSRQLLQCLREQRSQGFLCDCTVLV--GSAQ--FPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNSdiVTAPAFGLL 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 51703369 105 LEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18194  79 LDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-140 3.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 46.33  E-value: 3.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQ-QLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTnglRECGMETVTIEGVHPKVMQRLLEFAYTASIS 114
Cdd:cd18226  12 LNDDRQKQsSFCDLVITVE----GKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEFF 84

                        90       100
                ....*....|....*....|....*.
gi 51703369 115 VGEkcvihvmngavmYQMDSVVKACC 140
Cdd:cd18226  85 VYE------------NEIPLVLEAAK 98
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-143 3.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 46.21  E-value: 3.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  21 FQYSLADHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTnGLRECGM-----ETVTIEG 95
Cdd:cd18277   3 FAYESSVHSTNVLLSLNDQRKKDVLCDVTILVE----GQRFRAHRSVLAACSSYFHSRIV-GQADAELnitlpEEVTVKG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 51703369  96 VHPkvmqrLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18277  78 FEP-----LIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 147-223 5.07e-06

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 44.65  E-value: 5.07e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKY 223
Cdd:cd18503   1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 147-233 7.13e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 44.57  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDCE 226
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                ....*..
gi 51703369 227 NRRPYIQ 233
Cdd:cd18451  81 ERERYFE 87
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-151 9.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 45.62  E-value: 9.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  37 NELRLGQQLCDVKLKVKYNDVQdEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIE------GVHPKVMQRLLEFAYT 110
Cdd:cd18241  15 NEQRKQGLFCDITLAFGGAGGR-EFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPDPDTVEAVIQYMYT 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 51703369 111 ASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18241  94 GRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 1.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 45.42  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTnglrecgMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18243  15 HSDNLLHGLNLLWRKQLFCDVTLTAQ----GQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSN 151
Cdd:cd18243  84 LYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-139 1.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 45.41  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVkyNDVQdeFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18324   5 DHSRHLLQCLSEQRHQGFLCDCTVLV--GDAQ--FRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLE 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18324  81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVC 113
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-152 1.69e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 44.62  E-value: 1.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  63 AHKIVLASSSPVFRAMFTNGLREcGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18348  39 GHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 117

                        90
                ....*....|
gi 51703369 143 LIQQLDPSNA 152
Cdd:cd18348 118 LETSLSAKNA 127
Kelch_3 pfam13415
Galactose oxidase, central domain;
532-571 1.74e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 1.74e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 51703369   532 GKIYVLGGYD--GSTFLDGVECYNPATDTWTEVTQMTSGRSG 571
Cdd:pfam13415   2 DKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSG 43
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 521-565 2.34e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 41.94  E-value: 2.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 51703369   521 RRSALGVTVHQGKIYVLGGYD--GSTFLDGVECYNPATDTWTEVTQM 565
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-139 3.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 43.87  E-value: 3.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  27 DHTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLE 106
Cdd:cd18325   5 DHSRQLLQCLSQQRHQGFLCDCTVLVG----EAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLE 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 51703369 107 FAYTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18325  81 FMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113
Kelch_6 pfam13964
Kelch motif;
388-428 3.95e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 3.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 51703369   388 VIDGQIYAVGG-SHGCLHHNSVERYDPERDEWHMVSPMKTRR 428
Cdd:pfam13964   9 SVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 151-240 4.94e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 42.56  E-value: 4.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 151 NAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDcENRRP 230
Cdd:cd18470   5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                        90
                ....*....|
gi 51703369 231 YIQALLRAVR 240
Cdd:cd18470  84 YAADLLSNIR 93
Kelch_6 pfam13964
Kelch motif;
475-522 5.00e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 5.00e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 51703369   475 RSGAGACALDTSVYAMGGY-DGTDQLNSVERYDVEKDDWTFVAPMRHRR 522
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02713 PHA02713
hypothetical protein; Provisional
 483-576 6.62e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.77  E-value: 6.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  483 LDTSVYAMGGYDGTD-QLNSVERYDVEKDDWTFVAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWTE 561
Cdd:PHA02713 302 VDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKM 381

                         90
                 ....*....|....*
gi 51703369  562 VTQMTSGRSGVGVAI 576
Cdd:PHA02713 382 LPDMPIALSSYGMCV 396
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-153 6.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 42.91  E-value: 6.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  61 FVAHKIVLASSSPVFRAMFTN--GLRECGMETVTIEGVHPKVMQRLLEFAY---TASISVGEKCVIHVMNGAVMYQMDSV 135
Cdd:cd18350  36 FYAHKVLLVTASNRFKSLLTNksEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEIPIADVLELLSAASLFQLDAL 115

                        90
                ....*....|....*...
gi 51703369 136 VKACCDFLIQQLDPSNAI 153
Cdd:cd18350 116 QRHCEILCSQTINLENAV 133
PLN02153 PLN02153
epithiospecifier protein
 428-576 8.08e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.98  E-value: 8.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  428 RIGVGVAVLNRLLYAVGGFDGTNRLNSAECY--YPETDEWKdIASMN-----IVRSGAGACALDTSVYAMGGYDGTDQLN 500
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGELKPNEHIDKDLYvfDFNTHTWS-IAPANgdvprISCLGVRMVAVGTKLYIFGGRDEKREFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  501 SVERYDVEKDDWTFVAPMRHRRSALGVTVH-----QGKIYVLGGYDGSTFLD------GVECYNPATDTWTEVT---QMT 566
Cdd:PLN02153 102 DFYSYDTVKNEWTFLTKLDEEGGPEARTFHsmasdENHVYVFGGVSKGGLMKtperfrTIEAYNIADGKWVQLPdpgENF 181

                        170
                 ....*....|
gi 51703369  567 SGRSGVGVAI 576
Cdd:PLN02153 182 EKRGGAGFAV 191
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-139 8.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 42.65  E-value: 8.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  25 LADHTNQAFQIMNELRLGQQLCDVKLKVKyNDVqdeFVAHKIVLASSSPVFRAMFTNGlrecGMETVTIEGVHPKVMQRL 104
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVE-NAL---FRAHKNILAASSMYFKSLVLHD----NLINLDTDMVNPTVFRQI 72

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 51703369 105 LEFAYT----ASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18334  73 LDFIYTgkllTSDQPGEQNFNALLTAASYLQLHDLAALC 111
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-115 8.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 42.57  E-value: 8.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  36 MNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLrECGMETVT--------------IEGVHPKVM 101
Cdd:cd18195   9 LNEQRLRGLFCDVTLIAG----DTKFRAHRSVLAASSPYFRELLSSPL-PLGAAAVAaapgatqspervleLPGVKAGVF 83

                        90
                ....*....|....
gi 51703369 102 QRLLEFAYTASISV 115
Cdd:cd18195  84 SDVLNFIYSSRVAL 97
PHA02713 PHA02713
hypothetical protein; Provisional
 411-539 9.11e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.39  E-value: 9.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  411 YDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPETDEWKDIASMNIVRSGAGACALDTSVYA 489
Cdd:PHA02713 277 YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYA 356

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 51703369  490 MGGYDGTDQLNSVERYDVEKDDWTFVAPMRHRRSALGVTVHQGKIYVLGG 539
Cdd:PHA02713 357 IGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
PLN02193 PLN02193
nitrile-specifier protein
 428-576 9.82e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 9.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  428 RIGVGVAVLNRLLYAVGGFDGTNRLNSAECYY--PETDEWK------DIASMNIVrsGAGACALDTSVYAMGGYDGTDQL 499
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYVfdLETRTWSispatgDVPHLSCL--GVRMVSIGSTLYVFGGRDASRQY 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  500 NSVERYDVEKDDWTFVAPMRH---RRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWTEVT---QMTSGRSGVG 573
Cdd:PLN02193 244 NGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCStpgDSFSIRGGAG 323


                 ...
gi 51703369  574 VAI 576
Cdd:PLN02193 324 LEV 326
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 158-221 1.40e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 40.64  E-value: 1.40e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51703369 158 FAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWV 221
Cdd:cd18493  11 YAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
Kelch_3 pfam13415
Galactose oxidase, central domain;
437-483 1.58e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 1.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 51703369   437 NRLLYAVGG--FDGTNRLNSAECYYPETDEWKDIASMNIVRSGAGACAL 483
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 151-240 1.64e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 40.87  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 151 NAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDcENRRP 230
Cdd:cd18449   5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                        90
                ....*....|
gi 51703369 231 YIQALLRAVR 240
Cdd:cd18449  84 FAAKLMENIR 93
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 153-240 1.81e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 41.05  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 153 IGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHACINWVKYDcENRRPYI 232
Cdd:cd18465   7 LNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASA 85


                ....*...
gi 51703369 233 QALLRAVR 240
Cdd:cd18465  86 SHVLCHIR 93
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 165-228 2.45e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 40.43  E-value: 2.45e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51703369 165 HELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRcESEVFHACINWVKYDCENR 228
Cdd:cd18488  19 PELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAECQRR 81
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-145 2.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 41.11  E-value: 2.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  64 HKIVLaSSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFA----YTASISVGEKCVIHVMNGAVMYQMDSVVKAC 139
Cdd:cd18305  30 HKIYL-CQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVfgslYRDEIEIKPSRVVSILAAATLLQLDGLIQQC 108


                ....*.
gi 51703369 140 CDFLIQ 145
Cdd:cd18305 109 SEVMKE 114
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-118 2.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 40.93  E-value: 2.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKynDVQdeFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVE--DTK--FKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNF 76

                        90
                ....*....|.
gi 51703369 108 AYTASISVGEK 118
Cdd:cd18223  77 IYSSKVVVKRQ 87
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-153 3.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.77  E-value: 3.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  43 QQLCDvklKVKYNDV----QDE-FVAHKIVLASSSPVFRamFTNGlreCGMETVTIEGVHPKVMQRLLEFAYT--ASISV 115
Cdd:cd18303  10 ASLFD---KELYSDItiklADKsIPAHKFVLAARSEKWS--NENL---ASTNELDLSDISYEVVLALLRWLYTdeLDLTL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 51703369 116 GEKCVIHVMNGAVMYQMDSVVKACCDFLIQQLDPSNAI 153
Cdd:cd18303  82 DDEFLLELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
PHA02713 PHA02713
hypothetical protein; Provisional
 45-443 3.49e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 43.46  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369   45 LCDVKLKVKYNDvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMET-VTIEGVHPKVMQRLLEFAYTASISvgEKCVIHV 123
Cdd:PHA02713  25 LCDVIITIGDGE---EIKAHKTILAAGSKYFRTLFTTPMIIRDLVTrVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  124 MNGAVMYQMDSVVKAC------------CDFLIQQLDPSNAIGIATFAE---------------------QIGCHELHQK 170
Cdd:PHA02713 100 LKCADYLLIDDLVTDCesyikdytnhdtCIYMYHRLYEMSHIPIVKYIKrmlmsniptlittdafkktvfEILFDIISTN 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  171 AREYIYMQFGEVA-----------KQEEFFNLSSC---QLVNLVSRDELNVRCESEVFHACINWVKYDCENRRPYIQALl 236
Cdd:PHA02713 180 DNVYLYREGYKVTillkwleynyiTEEQLLCILSCidiQNLDKKSRLLLYSNKTINMYPSCIQFLLDNKQNRNIIPRQL- 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  237 rAVRCHSLTPNFLQlqlqRCeILKGDSRCQDYlSQIFqdlTLHKPTLPLQGRIpnVPQFIYVAGGYYRQSLSFLEAY--N 314
Cdd:PHA02713 259 -CLVCHDTKYNVCN----PC-ILVYNINTMEY-SVIS---TIPNHIINYASAI--VDNEIIIAGGYNFNNPSLNKVYkiN 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  315 PVDGEWLTLASLEMPRSGLAGCVLGGLFYAVGGRNNApdcnKDSGALDCYNPMNNQWSPCAAMSVPRNRVGAGVIDGQIY 394
Cdd:PHA02713 327 IENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGT----NVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIY 402

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51703369  395 AVGGS-----HGCLHH-------------NSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAV 443
Cdd:PHA02713 403 IIGGRtehidYTSVHHmnsidmeedthssNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
PRK14131 PRK14131
N-acetylneuraminate epimerase;
360-448 3.60e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.08  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  360 ALDCYNPmNNQWSPCAAM-SVPRNRVGAGVIDGQIYAVGGSHGCLH------HNSVERYDPERDEWHMV---SPMKTrrI 429
Cdd:PRK14131  54 KLDLNAP-SKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVYKYDPKTNSWQKLdtrSPVGL--A 130

                         90       100
                 ....*....|....*....|....*
gi 51703369  430 G-VGVAVLNRLLYAVGG-----FDG 448
Cdd:PRK14131 131 GhVAVSLHNGKAYITGGvnkniFDG 155
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 5.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 39.84  E-value: 5.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEgvhPKVMQRLLEF 107
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQ----GRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIE---AAAFENLLQL 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18200  74 IYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 6.30e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 39.88  E-value: 6.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGLREcGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVK----GVCFKAHKNVLAAFSQYFRSLFQNSSSQ-KNDVFHLDIKNVGGIGQILDF 75

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFL 143
Cdd:cd18233  76 MYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 45-114 6.36e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 39.65  E-value: 6.36e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51703369  45 LCDVKLKVKYNDvqdEFVAHKIVLASSSPVFRAMFTNGLRECGMET-VTIEgVHPKVMQRLLEFAYTASIS 114
Cdd:cd18302   5 LYDVTIVSEDGK---EFPCHKCVLVARLEYFHSMLSSSWIEASSCSaLTMP-IPSDILEIILDYLYTDEAS 71
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 6.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 39.36  E-value: 6.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyndvQDEFVAHKIVLASSSPVFRAMFTNGlrecGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVG----GRVFKAHWSVLACCSHFFQSLYGDG----TSGSVVLPESFAEVFGLLLDF 72

                        90       100       110
                ....*....|....*....|....*....|....*
gi 51703369 108 AYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDF 142
Cdd:cd18232  73 FYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-145 8.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 39.16  E-value: 8.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  47 DVKLKVKYNDVQdefvAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNG 126
Cdd:cd18298  14 DLKFRVDGKYIY----VHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDL 89

                        90
                ....*....|....*....
gi 51703369 127 AVMYQMDSVVKACCDFLIQ 145
Cdd:cd18298  90 ANSYCEERLKKLCEDIIKQ 108
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-117 9.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 38.70  E-value: 9.74e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 51703369  68 LASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGE 117
Cdd:cd18319  20 LIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQ 69
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-139 2.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 38.42  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  61 FVAHKIVLASSSPVFRAMFTNglrECGMETVTIEGVHPK--VMQRLLEFAY---TASISVGEKCVIHVMNGAVMYQMDSV 135
Cdd:cd18351  36 FYAHKVLLFTASPRFKALLSN---KPSAENTCIEISYVKyhIFQLVMQYLYcggTESLLIKNNEIMELLSAAKFFQLEAL 112


                ....
gi 51703369 136 VKAC 139
Cdd:cd18351 113 QRHC 116
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-114 3.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 37.90  E-value: 3.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  28 HTNQAFQIMNELRLGQQLCDVKLKVKyNDVqdeFVAHKIVLASSSPVFRAMFTNGlrecGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVVE-NSL---FRAHKNVLAASSGYFKSLVLHD----NLIHLDQDMVSPTVFQQILDF 74


                ....*..
gi 51703369 108 AYTASIS 114
Cdd:cd18216  75 IYTGKLL 81
Kelch_4 pfam13418
Galactose oxidase, central domain;
520-567 5.13e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 51703369   520 HRRSALGVTVHQGKIYVLGGYDGS-TFLDGVECYNPATDTWTEVTQMTS 567
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_6 pfam13964
Kelch motif;
329-381 7.82e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 7.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 51703369   329 PRSGLAGCVLGGLFYAVGGRNNApdcNKDSGALDCYNPMNNQWSPCAAMSVPR 381
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNA---SPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 380-424 8.35e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.62  E-value: 8.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 51703369   380 PRNRVGAGVIDGQIYAVGGS--HGCLHHNSVERYDPERDEWHMVSPM 424
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSdgLGDLSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-107 8.72e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 36.33  E-value: 8.72e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 51703369  56 DVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEF 107
Cdd:cd18191   9 DGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHY 60
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 147-216 9.15e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 36.28  E-value: 9.15e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369 147 LDPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVAKQEEFFNLSSCQLVNLVSRDELNVRCESEVFHA 216
Cdd:cd18461   1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEG 70
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-147 9.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 35.92  E-value: 9.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51703369  54 YNDVQDEFVAHKIVLASSSPVFRAMFTNGLRECGMETVTIEGVHPKVMQRLLEFAYTASISVGE--KCVIHVMNGAVMYQ 131
Cdd:cd18313   7 ETDNNSHIPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEmeKFGIHLLVLSHVYV 86

                        90
                ....*....|....*.
gi 51703369 132 MDSVVKACCDFLIQQL 147
Cdd:cd18313  87 VPQLKRVCEKGLEQGL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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