|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
465-775 |
2.52e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 98.08 E-value: 2.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 465 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 544
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 545 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 619
Cdd:COG4886 83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 620 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 699
Cdd:COG4886 148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72533596 700 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 775
Cdd:COG4886 217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
880-1022 |
4.52e-16 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 75.82 E-value: 4.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 880 YDAYVSYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 959
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72533596 960 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1022
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
573-774 |
3.73e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.81 E-value: 3.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 573 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 642
Cdd:cd21340 4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 643 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 722
Cdd:cd21340 72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 72533596 723 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 774
Cdd:cd21340 131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
63-442 |
1.03e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 63 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 140
Cdd:COG4886 72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 141 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 218
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 219 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 297
Cdd:COG4886 204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 298 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 377
Cdd:COG4886 261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72533596 378 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 442
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
283-772 |
3.62e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.57 E-value: 3.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 283 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 359
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 360 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 415
Cdd:PLN00113 188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 416 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 495
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 496 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 572
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 573 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 635
Cdd:PLN00113 374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 636 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 710
Cdd:PLN00113 449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72533596 711 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 772
Cdd:PLN00113 519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
880-1024 |
1.04e-10 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 61.23 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 880 YDAYVSYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 955
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 956 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1014
Cdd:pfam01582 76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150
|
170
....*....|
gi 72533596 1015 WQTLRNVVLT 1024
Cdd:pfam01582 151 WKKIAYDISN 160
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
640-700 |
2.33e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.33e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72533596 640 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 700
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
65-597 |
8.27e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 8.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 143
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 144 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 222
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 223 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 288
Cdd:PLN00113 211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 289 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 368
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 369 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 429
Cdd:PLN00113 363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 430 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 509
Cdd:PLN00113 440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 510 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 586
Cdd:PLN00113 504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570
|
570
....*....|....
gi 72533596 587 KVL---NLSHNNIY 597
Cdd:PLN00113 571 ESLvqvNISHNHLH 584
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
112-321 |
1.44e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.25 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 112 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 187
Cdd:cd21340 10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 188 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 254
Cdd:cd21340 80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 255 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 321
Cdd:cd21340 129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
287-349 |
1.56e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.56e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72533596 287 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 349
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
742-829 |
1.30e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 52.78 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 742 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 821
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....*...
gi 72533596 822 CVSDVTAV 829
Cdd:TIGR00864 78 SGCDEEYV 85
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
772-817 |
5.77e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 5.77e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 72533596 772 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 817
Cdd:smart00082 1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
465-775 |
2.52e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 98.08 E-value: 2.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 465 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 544
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 545 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 619
Cdd:COG4886 83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 620 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 699
Cdd:COG4886 148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72533596 700 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 775
Cdd:COG4886 217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
880-1022 |
4.52e-16 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 75.82 E-value: 4.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 880 YDAYVSYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 959
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72533596 960 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1022
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
484-772 |
8.92e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.58 E-value: 8.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 484 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 563
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSN 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 564 NshyfRIAGVTHHLEfiqNFTNLKVLNLSHNNIYTLTDKYNlESKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 643
Cdd:COG4886 192 N----QITDLPEPLG---NLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQL---------TDLPELGNLTNLEE 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 644 LDLSLNRLKHIPNEAFLnlpASLTELHINDNMLKFFNWTLLQ--QFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH 721
Cdd:COG4886 255 LDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKELEllLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 72533596 722 NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
Cdd:COG4886 332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
573-774 |
3.73e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.81 E-value: 3.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 573 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 642
Cdd:cd21340 4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 643 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 722
Cdd:cd21340 72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 72533596 723 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 774
Cdd:cd21340 131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
63-442 |
1.03e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 63 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 140
Cdd:COG4886 72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 141 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 218
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 219 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 297
Cdd:COG4886 204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 298 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 377
Cdd:COG4886 261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72533596 378 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 442
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
484-769 |
1.38e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.65 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 484 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 563
Cdd:COG4886 139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSG 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 564 NshyfriaGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 643
Cdd:COG4886 215 N-------QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNL--TNLEELDLSNNQL---------TDLPPLANLTNLKT 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 644 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNR 723
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 72533596 724 ISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLEL 769
Cdd:COG4886 357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
104-433 |
1.48e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.65 E-value: 1.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 104 NGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 183
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 184 NKVCEKTNIEDgvFETLTNLELLSLSFNSlshvPPKLPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfna 263
Cdd:COG4886 81 LLSLLLLGLTD--LGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNN------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 264 pfpcvpcdggaSINIDRFAFQNLTQLRYLNLSSTSLRKINaAWFKNMPHLKVLDLEFNYLvGEIasGAFLTMLPRLEILD 343
Cdd:COG4886 147 -----------QLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 344 LSFNYIKgsypqhiNISRNFSKLLSLRALHLRGYVFQELREddfqpLMQLPNLSTINLGINFIKQIDFklFQNFSNLEII 423
Cdd:COG4886 212 LSGNQLT-------DLPEPLANLTNLETLDLSNNQLTDLPE-----LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTL 277
|
330
....*....|
gi 72533596 424 YLSENRISPL 433
Cdd:COG4886 278 DLSNNQLTDL 287
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
85-541 |
2.73e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 66.88 E-value: 2.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 85 GLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQlpqiPSGLPESLTELSLIQNNIYNITKE 164
Cdd:COG4886 56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 165 gISRLINLKNLYLAWNcyfnkvcektNIEDgvfetltnlellslsfnslshVPPKLPS--SLRKLFLSNTQIKYISEEdF 242
Cdd:COG4886 132 -LANLTNLKELDLSNN----------QLTD---------------------LPEPLGNltNLKSLDLSNNQLTDLPEE-L 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 243 KGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF--AFQNLTQLRYLNLSSTSLRKINAAwFKNMPHLKVLDLEF 320
Cdd:COG4886 179 GNLTNLKELDLSNN--------------------QITDLpePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 321 NylvgEIASGAFLTMLPRLEILDLSFNYIKgsypqhinisrnfskllslralhlrgyvfqelredDFQPLMQLPNLSTIN 400
Cdd:COG4886 238 N----QLTDLPELGNLTNLEELDLSNNQLT-----------------------------------DLPPLANLTNLKTLD 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 401 LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYhftrpLIKPQCA 480
Cdd:COG4886 279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-----LALLTLL 353
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72533596 481 AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNR 541
Cdd:COG4886 354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
283-772 |
3.62e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.57 E-value: 3.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 283 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 359
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 360 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 415
Cdd:PLN00113 188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 416 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 495
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 496 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 572
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 573 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 635
Cdd:PLN00113 374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 636 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 710
Cdd:PLN00113 449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72533596 711 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 772
Cdd:PLN00113 519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
50-256 |
5.42e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 66.11 E-value: 5.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 50 SNRRLQEVPQTVG--KYVTELDLSDNFITHItNESFQGLQNLTKINLNHNpnvqhqngnpgiqsnglNITD--GAFLNLK 125
Cdd:COG4886 121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-----------------QLTDlpEELGNLT 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 126 NLRELLLEDNQLPQIPSGL--PESLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgvFETLTNL 203
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----------QLTD--LPELGNL 249
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 72533596 204 ellslsfnslshvppklpSSLRKLFLSNTQIKYISEEdfKGLINLTLLDLSGN 256
Cdd:COG4886 250 ------------------TNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNN 282
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
880-1024 |
1.04e-10 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 61.23 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 880 YDAYVSYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 955
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 956 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1014
Cdd:pfam01582 76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150
|
170
....*....|
gi 72533596 1015 WQTLRNVVLT 1024
Cdd:pfam01582 151 WKKIAYDISN 160
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
309-774 |
4.15e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.10 E-value: 4.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 309 NMPHLKVLDLEFNYLVGEIASGAFltMLPRLEILDLSFNYIKGSYPQHInisrnFSKLLSLRALHLRGYVFQelredDFQ 388
Cdd:PLN00113 67 NSSRVVSIDLSGKNISGKISSAIF--RLPYIQTINLSNNQLSGPIPDDI-----FTTSSSLRYLNLSNNNFT-----GSI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENrisPLVKDTRQSYANSSSFQ--------------RHIRKR 454
Cdd:PLN00113 135 PRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN---VLVGKIPNSLTNLTSLEfltlasnqlvgqipRELGQM 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 455 RSTDFEFDPHSNFYHFTrPLIKPQCAAYGKaLDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSaIPHVKY 534
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEI-PYEIGGLTSLNH-LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS-LQKLIS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQ-------NFT-----------NLKVLNLSHNNI 596
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQvlqlwsnKFSgeipknlgkhnNLTVLDLSTNNL 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 597 YTLTDKYNLESKSLVELVFSGNRLDilwndddnryISIFKGL---KNLTRLDLSLNRLKHIPNEAFLNLPAsLTELHIND 673
Cdd:PLN00113 369 TGEIPEGLCSSGNLFKLILFSNSLE----------GEIPKSLgacRSLRRVRLQDNSFSGELPSEFTKLPL-VYFLDISN 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 674 NMLKFFNWTLLQQFPRLELLDLRGNKLLfltDSLSDFTSS--LRTLLLSHNRISH-LPSGFLSeVSSLKHLDLSSNLLKT 750
Cdd:PLN00113 438 NNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFGSkrLENLDLSRNQFSGaVPRKLGS-LSELMQLKLSENKLSG 513
|
490 500
....*....|....*....|....
gi 72533596 751 INKSalETKTTTKLSMLELHGNPF 774
Cdd:PLN00113 514 EIPD--ELSSCKKLVSLDLSHNQL 535
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
640-700 |
2.33e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.33e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72533596 640 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 700
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
883-994 |
4.17e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 55.40 E-value: 4.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 883 YVSYDTKDASVTDWVINELryhleESRDKNVLLclEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYL 962
Cdd:pfam13676 2 FISYAGEDRAWAEWLADAL-----EAAGYRVWL--DRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
|
90 100 110
....*....|....*....|....*....|....*..
gi 72533596 963 ALQRLMDENmdVIIFILLE-----PVLQHSQYLRLRQ 994
Cdd:pfam13676 75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
65-597 |
8.27e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 8.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 143
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 144 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 222
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 223 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 288
Cdd:PLN00113 211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 289 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 368
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 369 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 429
Cdd:PLN00113 363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 430 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 509
Cdd:PLN00113 440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 510 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 586
Cdd:PLN00113 504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570
|
570
....*....|....
gi 72533596 587 KVL---NLSHNNIY 597
Cdd:PLN00113 571 ESLvqvNISHNHLH 584
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
216-722 |
1.76e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.02 E-value: 1.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 216 VPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS 295
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 296 STSLRKINAAWFKNMPHLKVLDLEFNylvgeiasgAFLTMLPRLEILDLSFNYIKgsypqhiNISRNFSKLLSLRALHLR 375
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLT-------DLPEELANLTNLKELDLS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 376 GYVFQELREddfqPLMQLPNLSTINLGINFIKQIDfKLFQNFSNLEIIYLSENRISPLvkdtrqsyansssfqrhirkrr 455
Cdd:COG4886 145 NNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 456 stdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYL 535
Cdd:COG4886 198 ------------------------------------------PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETL 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 536 DLTNNRLDfdNASALTELSDLEVLDLSYNshyfRIAgvthHLEFIQNFTNLKVLNLSHNNIYTLtdkyNLESKSLVELVF 615
Cdd:COG4886 234 DLSNNQLT--DLPELGNLTNLEELDLSNN----QLT----DLPPLANLTNLKTLDLSNNQLTDL----KLKELELLLGLN 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 616 SGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDL 695
Cdd:COG4886 300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
|
490 500
....*....|....*....|....*..
gi 72533596 696 RGNKLLFLTDSLSDFTSSLRTLLLSHN 722
Cdd:COG4886 380 LTLALLLLTLLLLLLTTTAGVLLLTLA 406
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
486-701 |
2.44e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.98 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 486 LDLSLNSIFFIGPNQFENLPDIACL-NLSANSNAQVLSGTEFSA------IPHVKYLDLTNNRLD----FDNASALTELS 554
Cdd:cd00116 86 LDLSDNALGPDGCGVLESLLRSSSLqELKLNNNGLGDRGLRLLAkglkdlPPALEKLVLGRNRLEgascEALAKALRANR 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 555 DLEVLDLSYNShyFRIAGVTHHLEFIQNFTNLKVLNLSHNniyTLTDKynlESKSLVElvfsgnrldilwndddnryisI 634
Cdd:cd00116 166 DLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNN---GLTDE---GASALAE---------------------T 216
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72533596 635 FKGLKNLTRLDLSLNRLKHIP----NEAFLNLPASLTELHINDNMLKFFNW----TLLQQFPRLELLDLRGNKLL 701
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGaaalASALLSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGNKFG 291
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
220-676 |
8.70e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 56.39 E-value: 8.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 220 LPSSLRKLFLSNTqikyiseeDFKGLI------NLTLLDLSGN-----CPRCFNAPFPCVPCDGGASINIDRF--AFQNL 286
Cdd:PLN00113 116 TSSSLRYLNLSNN--------NFTGSIprgsipNLETLDLSNNmlsgeIPNDIGSFSSLKVLDLGGNVLVGKIpnSLTNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 287 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINisrNFSKL 366
Cdd:PLN00113 188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYNNLTGPIPSSLG---NLKNL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 367 LSLralhlrgYVFQELREDDFQP-LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYAN-- 443
Cdd:PLN00113 263 QYL-------FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRlq 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 444 -----SSSFQRHIRKrrstdfEFDPHSNFyhftrplikpqcaaygKALDLSLNS------------------IFFIGPNQ 500
Cdd:PLN00113 336 vlqlwSNKFSGEIPK------NLGKHNNL----------------TVLDLSTNNltgeipeglcssgnlfklILFSNSLE 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 501 FENLPDI-AC-----LNLSANSNAQVLSgTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFriagvt 574
Cdd:PLN00113 394 GEIPKSLgACrslrrVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG------ 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 575 hhlEFIQNF--TNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDdnryisiFKGLKNLTRLDLSLNRLK 652
Cdd:PLN00113 467 ---GLPDSFgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE-------LSSCKKLVSLDLSHNQLS 536
|
490 500
....*....|....*....|....*
gi 72533596 653 -HIPnEAFLNLPAsLTELHINDNML 676
Cdd:PLN00113 537 gQIP-ASFSEMPV-LSQLDLSQNQL 559
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
112-321 |
1.44e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.25 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 112 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 187
Cdd:cd21340 10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 188 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 254
Cdd:cd21340 80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 255 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 321
Cdd:cd21340 129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
287-349 |
1.56e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.56e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72533596 287 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 349
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
712-774 |
2.05e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 2.05e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72533596 712 SSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALEtkTTTKLSMLELHGNPF 774
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
688-748 |
2.67e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 2.67e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72533596 688 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLL 748
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
512-748 |
2.78e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.70 E-value: 2.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 512 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHyfriaGVTHHLEFIQNftNLKVLNL 591
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSN-----QLTSIPATLPD--TIQEMEL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 592 SHNNIYTLTDKynLESkSLVELVFSGNRLDILWND--DDNRYISIFKglknltrldlslNRLKHIPNeaflNLPASLTEL 669
Cdd:PRK15370 249 SINRITELPER--LPS-ALQSLDLFHNKISCLPENlpEELRYLSVYD------------NSIRTLPA----HLPSGITHL 309
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72533596 670 HINDNMLKFFNWTLLqqfPRLELLDLRGNKLLFLTDSLSdftSSLRTLLLSHNRISHLPSGFlseVSSLKHLDLSSNLL 748
Cdd:PRK15370 310 NVQSNSLTALPETLP---PGLKTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPETL---PPTITTLDVSRNAL 379
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
65-137 |
3.09e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 3.09e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72533596 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiqsNGLNITDGAFLNLKNLRELLLEDNQL 137
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN--------------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
505-750 |
9.03e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 9.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 505 PDIACLNLSANSNAQVLSGTE-----FSAIPHVKYLDLTNNRLDFDNA---SALTELSDLEVLDLSYNSH-----YFRIA 571
Cdd:cd00116 51 PSLKELCLSLNETGRIPRGLQsllqgLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLgdrglRLLAK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 572 GVTHHLEfiqnftNLKVLNLSHNNIY--TLTDKYNLESK--SLVELVFSGNRLdilwNDDDNRYIS-IFKGLKNLTRLDL 646
Cdd:cd00116 131 GLKDLPP------ALEKLVLGRNRLEgaSCEALAKALRAnrDLKELNLANNGI----GDAGIRALAeGLKANCNLEVLDL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 647 SLNRLKHIPNEAF---LNLPASLTELHINDNmlkffnwtllqqfprleLLDLRGnkLLFLTDSLSDFTSSLRTLLLSHNR 723
Cdd:cd00116 201 NNNGLTDEGASALaetLASLKSLEVLNLGDN-----------------NLTDAG--AAALASALLSPNISLLTLSLSCND 261
|
250 260 270
....*....|....*....|....*....|.
gi 72533596 724 ISHLPSGFLSEV----SSLKHLDLSSNLLKT 750
Cdd:cd00116 262 ITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
742-829 |
1.30e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 52.78 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 742 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 821
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....*...
gi 72533596 822 CVSDVTAV 829
Cdd:TIGR00864 78 SGCDEEYV 85
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
511-724 |
1.61e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 51.71 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 511 NLSANSNAQVLSGTefsaiPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNL 586
Cdd:COG5238 222 DEGAEILAEALKGN-----KSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGN--QIGAEGAIALAKALQGNTTL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 587 KVLNLSHNNIytlTDK------YNLE-SKSLVELVFSGNRLDilwnddDNRYISIFKGLK---NLTRLDLSLNRLKHIPN 656
Cdd:COG5238 295 TSLDLSVNRI---GDEgaialaEGLQgNKTLHTLNLAYNGIG------AQGAIALAKALQentTLHSLDLSDNQIGDEGA 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72533596 657 EAFLNLPASLTELHindnmlkffnwtllqqfprleLLDLRGNKL-----LFLTDSLSdfTSSLRTLLLSHNRI 724
Cdd:COG5238 366 IALAKYLEGNTTLR---------------------ELNLGKNNIgkqgaEALIDALQ--TNRLHTLILDGNLI 415
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
277-323 |
2.11e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.98 E-value: 2.11e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 72533596 277 NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 323
Cdd:pfam13855 15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
529-746 |
2.86e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 50.43 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 529 IPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTD--- 601
Cdd:cd00116 22 LLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvl 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 602 KYNLESKSLVELVFSGNRLDilwnDDDNRYISifKGLK----NLTRLDLSLNRLKHIPNEAFLN-LPA--SLTELHINDN 674
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLG----DRGLRLLA--KGLKdlppALEKLVLGRNRLEGASCEALAKaLRAnrDLKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 675 MLKFFNWTLLQQ----FPRLELLDLRGNKL-----LFLTDSLSDfTSSLRTLLLSHNRI-----SHLPSGFLSEVSSLKH 740
Cdd:cd00116 176 GIGDAGIRALAEglkaNCNLEVLDLNNNGLtdegaSALAETLAS-LKSLEVLNLGDNNLtdagaAALASALLSPNISLLT 254
|
....*.
gi 72533596 741 LDLSSN 746
Cdd:cd00116 255 LSLSCN 260
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
639-751 |
3.08e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.24 E-value: 3.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 639 KNLTRLDLSLNRLKHIPNeaflNLPASLTELHINDNMLKFFNWTLLQQfprLELLDLRGNKLLFLTDSLSdftSSLRTLL 718
Cdd:PRK15370 199 EQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSIPATLPDT---IQEMELSINRITELPERLP---SALQSLD 268
|
90 100 110
....*....|....*....|....*....|...
gi 72533596 719 LSHNRISHLPSGFLSEvssLKHLDLSSNLLKTI 751
Cdd:PRK15370 269 LFHNKISCLPENLPEE---LRYLSVYDNSIRTL 298
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
772-817 |
5.77e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 5.77e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 72533596 772 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 817
Cdd:smart00082 1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
584-676 |
5.81e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 584 TNLKVLNLSHNNIYTLTDkynleskslvelvfsgnrldilwndddnryiSIFKGLKNLTRLDLSLNRLKHIPNEAFLNLP 663
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDD-------------------------------GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
|
90
....*....|...
gi 72533596 664 aSLTELHINDNML 676
Cdd:pfam13855 50 -SLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
66-181 |
3.45e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.32 E-value: 3.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 66 TELDLSDNFITHITNesFQGLQNLTKINLNHNPnvqhqngnpgIQS-NGLNitdgaflNLKNLRELLLEDNQL------- 137
Cdd:cd21340 49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNR----------ISVvEGLE-------NLTNLEELHIENQRLppgeklt 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 72533596 138 --PQIPSGLPESLTELSLIQNNIYNItkEGISRLINLKNLYLAWNC 181
Cdd:cd21340 110 fdPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
530-596 |
3.50e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 3.50e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72533596 530 PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNShyfriagvthhLEFI-----QNFTNLKVLNLSHNNI 596
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-----------LTTLspgafSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
222-299 |
8.39e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 8.39e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 72533596 222 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCfnapfpcvpcdggasinIDRFAFQNLTQLRYLNLSSTSL 299
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
561-773 |
2.52e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.27 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 561 LSYNSHYFRIAGVTHHLEFIQNftnLKVLNLSHNNIYTLTDKY---NLESK-SLVELVFSGNRLDilwNDDDN--RYISI 634
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKAlasALRPQpSLKELCLSLNETG---RIPRGlqSLLQG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 635 FKGLKNLTRLDLSLNRLKHIPNEAFLNL--PASLTELHINDNML-----KFFNWTLLQQFPRLELLDLRGNKL-LFLTDS 706
Cdd:cd00116 77 LTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLeGASCEA 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 72533596 707 LSD---FTSSLRTLLLSHNRISHlpSGF------LSEVSSLKHLDLSSNLLKTINKSALET--KTTTKLSMLELHGNP 773
Cdd:cd00116 157 LAKalrANRDLKELNLANNGIGD--AGIralaegLKANCNLEVLDLNNNGLTDEGASALAEtlASLKSLEVLNLGDNN 232
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
123-266 |
2.80e-04 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.07 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 123 NLK-NLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLknlylawNCYFNKV-CEKTNIEDGVfETL 200
Cdd:PRK15370 217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL-------DLFHNKIsCLPENLPEEL-RYL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72533596 201 TnlellsLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEedfKGLINLTLLDLSGNCPRCFNAPFP 266
Cdd:PRK15370 289 S------VYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLP 345
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
519-757 |
3.23e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 3.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 519 QVLSGTEFSAIPHVKYLDLTNNRLDFDN----ASALTELSDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNLKVLNLSHN 594
Cdd:COG5238 169 AAISMAKALQNNSVETVYLGCNQIGDEGieelAEALTQNTTVTTLWLKRN--PIGDEGAEILAEALKGNKSLTTLDLSNN 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 595 NIytlTD-------KYNLESKSLVELVFSGNRLdilwndDDNRYISIFKGL---KNLTRLDLSLNRlkhIPNEAFLNL-- 662
Cdd:COG5238 247 QI---GDegvialaEALKNNTTVETLYLSGNQI------GAEGAIALAKALqgnTTLTSLDLSVNR---IGDEGAIALae 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 663 ----PASLTELHINDNMLKFFNWTLL----QQFPRLELLDLRGNKL-----LFLTDSLSDFTsSLRTLLLSHNRIShlPS 729
Cdd:COG5238 315 glqgNKTLHTLNLAYNGIGAQGAIALakalQENTTLHSLDLSDNQIgdegaIALAKYLEGNT-TLRELNLGKNNIG--KQ 391
|
250 260 270
....*....|....*....|....*....|...
gi 72533596 730 GFLSEVSSLKH-----LDLSSNLLKTINKSALE 757
Cdd:COG5238 392 GAEALIDALQTnrlhtLILDGNLIGAEAQQRLE 424
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
286-354 |
3.95e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 44.42 E-value: 3.95e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72533596 286 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAsgAFLTMLPRLEILDLSFNYIKGSYP 354
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP--ESLGQLTSLRILNLNGNSLSGRVP 507
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
311-376 |
3.97e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 3.97e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72533596 311 PHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYIKGSYPQHinisrnFSKLLSLRALHLRG 376
Cdd:pfam13855 1 PNLRSLDLSNNRLTS-LDDGAFKG-LSNLKVLDLSNNLLTTLSPGA------FSGLPSLRYLDLSG 58
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
486-542 |
5.02e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 5.02e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 72533596 486 LDLSLNSIFFIGPNQFENLPDIACLNLSaNSNAQVLSGTEFSAIPHVKYLDLTNNRL 542
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLS-NNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
510-564 |
5.60e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 5.60e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 72533596 510 LNLSANsNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 564
Cdd:pfam13855 6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
266-376 |
6.11e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 6.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 266 PCVPCD---GGASINIDRFAFQNLtqLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIaSGAFLTMlPRLEIL 342
Cdd:PLN03150 396 PCVPQQhpwSGADCQFDSTKGKWF--IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI-PPSLGSI-TSLEVL 471
|
90 100 110
....*....|....*....|....*....|....
gi 72533596 343 DLSFNYIKGSYPQHInisrnfSKLLSLRALHLRG 376
Cdd:PLN03150 472 DLSYNSFNGSIPESL------GQLTSLRILNLNG 499
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
586-656 |
1.80e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.80e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 72533596 586 LKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLDilwndDDNRYISIFKGLKNLTRLDLSLNRLKHIPN 656
Cdd:cd21340 122 LRVLNISGNNIDSLEPLAPL--RNLEQLDASNNQIS-----DLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
23-175 |
2.26e-03 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 41.99 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 23 ELCAEENFSRSYPcdEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN------H 96
Cdd:PRK15370 224 TLYANSNQLTSIP--ATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSirtlpaH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 97 NPN-VQHQNgnpgIQSNGLNITDGAFLnlKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIY--------NITKEGIS 167
Cdd:PRK15370 302 LPSgITHLN----VQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQITvlpetlppTITTLDVS 375
|
170
....*....|.
gi 72533596 168 R--LINL-KNL 175
Cdd:PRK15370 376 RnaLTNLpENL 386
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
125-362 |
3.28e-03 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 41.61 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 125 KNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNItKEGISRliNLKNLYLAWNcyfnkvcEKTNIEDGVFETLtnlE 204
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSN-------QLTSIPATLPDTI---Q 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 205 LLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDlsgNCPRCFNAPFPcvpcdggasinidrfafq 284
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPAHLP------------------ 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72533596 285 nlTQLRYLNLSSTSLRKINAAWfknMPHLKVLDLEFNYLVGEIASgafltMLPRLEILDLSFNYIK---GSYP---QHIN 358
Cdd:PRK15370 304 --SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPAS-----LPPELQVLDVSKNQITvlpETLPptiTTLD 373
|
....
gi 72533596 359 ISRN 362
Cdd:PRK15370 374 VSRN 377
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
523-594 |
4.82e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.95 E-value: 4.82e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72533596 523 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAgvthhlEFIQNFTNLKVLNLSHN 594
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP------ESLGQLTSLRILNLNGN 500
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
394-431 |
9.83e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 9.83e-03
10 20 30
....*....|....*....|....*....|....*...
gi 72533596 394 PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRIS 431
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
|
|
| |
