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Full Results
HSP90AA1 protein, partial [Homo sapiens]
Protein Classification
HSP90 family protein ( domain architecture ID 1903338 )
HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction
List of domain hits
Name
Accession
Description
Interval
E-value
HSP90 super family
cl46693 Hsp90 protein;
18-579
0e+00
Hsp90 protein;
PTZ00272 :Pssm-ID: 481033
Cd Length: 701
Bit Score: 751.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 18 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P N K QDR TLT IV D T GIG 97
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 98 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 177
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 178 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DEA E EKEDKE E EK E KEE kesedkpe 257
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D EDE E DTKKAD E DG E EPK -------- 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 258 I E D V gs D E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWED HL A V KHFSVEGQLEF 337
Cdd:PTZ00272 235 V E E V -- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWED PA A T KHFSVEGQLEF 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 338 R ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L V 417
Cdd:PTZ00272 310 R SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I V 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 418 KKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IYYITG E 497
Cdd:PTZ00272 390 KKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IYYITG D 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 498 T K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK D 577
Cdd:PTZ00272 470 S K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK E 549
..
gi 83318444 578 I L 579
Cdd:PTZ00272 550 V L 551
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
18-579
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 751.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 18 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P N K QDR TLT IV D T GIG 97
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 98 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 177
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 178 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DEA E EKEDKE E EK E KEE kesedkpe 257
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D EDE E DTKKAD E DG E EPK -------- 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 258 I E D V gs D E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWED HL A V KHFSVEGQLEF 337
Cdd:PTZ00272 235 V E E V -- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWED PA A T KHFSVEGQLEF 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 338 R ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L V 417
Cdd:PTZ00272 310 R SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I V 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 418 KKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IYYITG E 497
Cdd:PTZ00272 390 KKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IYYITG D 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 498 T K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK D 577
Cdd:PTZ00272 470 S K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK E 549
..
gi 83318444 578 I L 579
Cdd:PTZ00272 550 V L 551
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-546
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 639.47
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 16 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R YES LTDP SKLDSGKE L H I NLIPN K QDR TLTI V D T G 95
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEIFLRELISN A SDA I DK L R FLA LTDP ELKEEDGD L K I RIEVD K EAK TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 96 IGMT KADL I N NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KV T V I T KH -- N D D E QYA WES SAG G SF T 171
Cdd:COG0326 82 IGMT REEV I E NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSA FM VA D KV E V V T RS ag E D A E AVR WES DGD G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 172 VRTDTGEP mg RGT KVI LHLKED QT E Y LEE R R IK EI V KK H S Q FI GY PI TLFV E K E RDK E V sddeaeekedkeeekekeeke 251
Cdd:COG0326 162 IEEAEKAE -- RGT EIT LHLKED AE E F LEE W R LR EI I KK Y S D FI PV PI KMEG E E E ETE E D --------------------- 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 252 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D W ED H L AVK H FS V 331
Cdd:COG0326 219 ------------------------------------ E TI N SATAL WTR SKSE IT D EEY K EFYK H L FH D F ED P L FWI H LN V 262
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 332 EG QL E FRA LL FV P RR APFDL F e N R KK K NN IKLYV R RVFIMD NC E E L I PEYL N F I RGVVDS E DLPLN I SRE M LQ QSKI LK V 411
Cdd:COG0326 263 EG PF E YTG LL YI P KK APFDL Y - D R DR K GG IKLYV K RVFIMD DA E D L L PEYL R F V RGVVDS P DLPLN V SRE I LQ EDRQ LK K 341
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 412 IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K K LSE LLR YYTSA s GDEM V S L KD Y CT RMKE N QK H 490
Cdd:COG0326 342 IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GLVL K E G AL ED FK NR E K IAD LLR FESTK - EGGY V T L AE Y VE RMKE G QK K 420
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 83318444 491 IYYITGE TKDQVAN S AFV E RLRKH G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK 546
Cdd:COG0326 421 IYYITGE SREAAEQ S PHL E IFKAK G I EV LLLTD PIDE FLISH L E EF D GK KFK SV DS 476
HSP90
pfam00183 Hsp90 protein;
196-579
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 584.13
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 196 EYLEE RR IKE I VKK H S Q FI GY PI T L F VEKE RDK EV S D D E A EE K E DK EEE KEKEE K esedkpe I E DVG sdeeeek KDGD KK 275
Cdd:pfam00183 1 EYLEE KK IKE L VKK Y S E FI NF PI Y L W VEKE EEV EV P D E E E EE E E EE EEE EDDDP K ------- V E EED ------- EEEE KK 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 276 K K KK I KE KYIDQ E E LNKTKPIWTRNP DDI T N EEY G EFYKSL TN DWED H LAVKHFSVEG QL EF RA LLF V P R RAPFDLFEN R 355
Cdd:pfam00183 67 K T KK V KE TVWEW E L LNKTKPIWTRNP KEV T E EEY A EFYKSL SK DWED P LAVKHFSVEG EV EF KS LLF I P K RAPFDLFEN K 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 356 KKKNNIKLYVRRVFI M D NC E E LIPEYLNF IR GVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K C L EL F T E L AE D KE N YK 435
Cdd:pfam00183 147 KKKNNIKLYVRRVFI T D DF E D LIPEYLNF VK GVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K A L DM F K E I AE E KE D YK 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 436 KF YEQ F S KN I KLGI H EDS Q NR K KL SE LLR Y Y T S A SGDE MV SL K DY CT RMKE N QKHIYYITGE T K DQ V A NS A F V ERL R K H G 515
Cdd:pfam00183 227 KF WKE F G KN L KLGI I EDS S NR N KL AK LLR F Y S S K SGDE LT SL D DY VS RMKE G QKHIYYITGE S K EE V E NS P F L ERL K K K G 306
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 83318444 516 L EV I Y MIE PIDEY C VQQLKEF E GK T LV S V T KEGLEL P EDEEEKKK Q EE K K TK FE N L C K IM KD I L 579
Cdd:pfam00183 307 Y EV L Y LTD PIDEY A VQQLKEF D GK K LV N V A KEGLEL E EDEEEKKK D EE L K KE FE P L T K WL KD V L 370
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214
9.34e-114
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 336.42
E-value: 9.34e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 28 QL MS LII NTF YSNKEIFLRELISN S SDALDK I RY E SLTDPS K LD SGK EL H I NLI P N K QD RTLTI V DTGIGMTK AD LINNL 107
Cdd:cd16927 2 QL LD LII HSL YSNKEIFLRELISN A SDALDK L RY L SLTDPS L LD DDP EL E I RIS P D K EN RTLTI S DTGIGMTK EE LINNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 108 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSA YL VA E KVTV I TK HN - DDE Q Y A WES SA GGS F T VRTDT GE P m GRGTK 185
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSA FM VA D KVTV T TK SA g DDE G Y R WES DG GGS Y T IEEAE GE L - GRGTK 160
170 180
....*....|....*....|....*....
gi 83318444 186 VI LHLKED QT E Y LEE R RIKE I VKK H S Q FI 214
Cdd:cd16927 161 IT LHLKED AK E F LEE A RIKE L VKK Y S D FI 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191
1.12e-11
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 61.90
E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 40 NKEIF LR ELI SN SS D ALD K IRY E sltdpsklds G KELHIN L IPNKQDRTL T IV D T G I G MTKA DL innlgtiaksg T K A F M 119
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTP E ---------- G GRITVT L ERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83318444 120 EALQAGADISM IG QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SFT V RTDT gepm G R GT KVILH L K 191
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLV E LH ------------------ GG EIS V ESEP ---- G G GT TFTIT L P 109
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
18-579
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 751.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 18 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P N K QDR TLT IV D T GIG 97
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 98 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 177
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 178 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DEA E EKEDKE E EK E KEE kesedkpe 257
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D EDE E DTKKAD E DG E EPK -------- 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 258 I E D V gs D E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWED HL A V KHFSVEGQLEF 337
Cdd:PTZ00272 235 V E E V -- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWED PA A T KHFSVEGQLEF 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 338 R ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L V 417
Cdd:PTZ00272 310 R SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I V 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 418 KKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IYYITG E 497
Cdd:PTZ00272 390 KKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IYYITG D 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 498 T K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK D 577
Cdd:PTZ00272 470 S K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK E 549
..
gi 83318444 578 I L 579
Cdd:PTZ00272 550 V L 551
PRK05218
PRK05218 heat shock protein 90; Provisional
16-546
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 654.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 16 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R Y E S LTDP SKLDSGKE L H I NLIPN K QD RTLTI V D T G 95
Cdd:PRK05218 2 AM ET GE FQAE VK QL LH L M I HSL YSNKEIFLRELISN A SDA I DK L R F E A LTDP ALYEGDGD L K I RISFD K EA RTLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 96 IGMT KADL I N NLGTIAKSGTK A F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KVTVIT KH -- NDD E QYA WES SAG G SF T 171
Cdd:PRK05218 82 IGMT REEV I E NLGTIAKSGTK E F L E K L K gd QKK D SQL IGQFGVGFYSA FM VA D KVTVIT RS ag PAA E AVR WES DGE G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 172 VRTDTG E P mg RGT KVI LHLKED QT E Y L E E R RI KE I V KK H S Q FI GY PI T L FV E K E rdkevsddeaeekedkeeekekeeke 251
Cdd:PRK05218 162 IEEIEK E E -- RGT EIT LHLKED ED E F L D E W RI RS I I KK Y S D FI PV PI K L EK E E E -------------------------- 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 252 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D WE D H L AVK H FS V 331
Cdd:PRK05218 214 ------------------------------------ E TI N SASAL WTR SKSE IT D EEY K EFYK H L AH D FD D P L FWI H NN V 257
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 332 EG QL E FRA LL FV P RR APFDLF e NR KK K NNI KLYV R RVFIMD NC EEL I PEYL N F IR GV V DSEDLPLN I SRE M LQ QSKIL K V 411
Cdd:PRK05218 258 EG PF E YTG LL YI P KK APFDLF - NR DR K GGL KLYV K RVFIMD DA EEL L PEYL R F VK GV I DSEDLPLN V SRE I LQ EDRVV K K 336
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 412 IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K KL SE LLR YYTSAS G d EM VSL KD Y CT RMKE N QK H 490
Cdd:PRK05218 337 IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GPVL K E G LY ED FA NR E KL AK LLR FASTHE G - KY VSL AE Y VE RMKE G QK K 415
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 83318444 491 IYYITG ETKDQVA NS AFV E RLR K H G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK 546
Cdd:PRK05218 416 IYYITG DSREAAK NS PHL E LFK K K G I EV LLLTD PIDE FWISY L E EF D GK PFK SV AR 471
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-546
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 639.47
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 16 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R YES LTDP SKLDSGKE L H I NLIPN K QDR TLTI V D T G 95
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEIFLRELISN A SDA I DK L R FLA LTDP ELKEEDGD L K I RIEVD K EAK TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 96 IGMT KADL I N NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KV T V I T KH -- N D D E QYA WES SAG G SF T 171
Cdd:COG0326 82 IGMT REEV I E NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSA FM VA D KV E V V T RS ag E D A E AVR WES DGD G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 172 VRTDTGEP mg RGT KVI LHLKED QT E Y LEE R R IK EI V KK H S Q FI GY PI TLFV E K E RDK E V sddeaeekedkeeekekeeke 251
Cdd:COG0326 162 IEEAEKAE -- RGT EIT LHLKED AE E F LEE W R LR EI I KK Y S D FI PV PI KMEG E E E ETE E D --------------------- 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 252 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D W ED H L AVK H FS V 331
Cdd:COG0326 219 ------------------------------------ E TI N SATAL WTR SKSE IT D EEY K EFYK H L FH D F ED P L FWI H LN V 262
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 332 EG QL E FRA LL FV P RR APFDL F e N R KK K NN IKLYV R RVFIMD NC E E L I PEYL N F I RGVVDS E DLPLN I SRE M LQ QSKI LK V 411
Cdd:COG0326 263 EG PF E YTG LL YI P KK APFDL Y - D R DR K GG IKLYV K RVFIMD DA E D L L PEYL R F V RGVVDS P DLPLN V SRE I LQ EDRQ LK K 341
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 412 IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K K LSE LLR YYTSA s GDEM V S L KD Y CT RMKE N QK H 490
Cdd:COG0326 342 IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GLVL K E G AL ED FK NR E K IAD LLR FESTK - EGGY V T L AE Y VE RMKE G QK K 420
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 83318444 491 IYYITGE TKDQVAN S AFV E RLRKH G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK 546
Cdd:COG0326 421 IYYITGE SREAAEQ S PHL E IFKAK G I EV LLLTD PIDE FLISH L E EF D GK KFK SV DS 476
HSP90
pfam00183 Hsp90 protein;
196-579
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 584.13
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 196 EYLEE RR IKE I VKK H S Q FI GY PI T L F VEKE RDK EV S D D E A EE K E DK EEE KEKEE K esedkpe I E DVG sdeeeek KDGD KK 275
Cdd:pfam00183 1 EYLEE KK IKE L VKK Y S E FI NF PI Y L W VEKE EEV EV P D E E E EE E E EE EEE EDDDP K ------- V E EED ------- EEEE KK 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 276 K K KK I KE KYIDQ E E LNKTKPIWTRNP DDI T N EEY G EFYKSL TN DWED H LAVKHFSVEG QL EF RA LLF V P R RAPFDLFEN R 355
Cdd:pfam00183 67 K T KK V KE TVWEW E L LNKTKPIWTRNP KEV T E EEY A EFYKSL SK DWED P LAVKHFSVEG EV EF KS LLF I P K RAPFDLFEN K 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 356 KKKNNIKLYVRRVFI M D NC E E LIPEYLNF IR GVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K C L EL F T E L AE D KE N YK 435
Cdd:pfam00183 147 KKKNNIKLYVRRVFI T D DF E D LIPEYLNF VK GVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K A L DM F K E I AE E KE D YK 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 436 KF YEQ F S KN I KLGI H EDS Q NR K KL SE LLR Y Y T S A SGDE MV SL K DY CT RMKE N QKHIYYITGE T K DQ V A NS A F V ERL R K H G 515
Cdd:pfam00183 227 KF WKE F G KN L KLGI I EDS S NR N KL AK LLR F Y S S K SGDE LT SL D DY VS RMKE G QKHIYYITGE S K EE V E NS P F L ERL K K K G 306
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 83318444 516 L EV I Y MIE PIDEY C VQQLKEF E GK T LV S V T KEGLEL P EDEEEKKK Q EE K K TK FE N L C K IM KD I L 579
Cdd:pfam00183 307 Y EV L Y LTD PIDEY A VQQLKEF D GK K LV N V A KEGLEL E EDEEEKKK D EE L K KE FE P L T K WL KD V L 370
PTZ00130
PTZ00130 heat shock protein 90; Provisional
3-546
5.13e-134
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 410.59
E-value: 5.13e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 3 E E TQTQDQ P MEE ee V E TFAF Q A E IAQ LM SL I I N TF Y SN KE I FLRELISN SS DAL D KIR YE SL T D P S K L DSG K E L H I NLIP 82
Cdd:PTZ00130 53 P E IEDGEK P TSG -- I E QHQY Q T E VTR LM DI I V N SL Y TQ KE V FLRELISN AA DAL E KIR FL SL S D E S V L GEE K K L E I RISA 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 83 NK QDRT L T I V DTGIGMTK A DLINNLGTIAKSGT KA F M EA L - QA G A D I S M IGQFGVGFYSA Y LVA E KV T V I TK H N D DEQY A 161
Cdd:PTZ00130 131 NK EKNI L S I T DTGIGMTK E DLINNLGTIAKSGT SN F L EA I s KS G G D M S L IGQFGVGFYSA F LVA D KV I V Y TK N N N DEQY I 210
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 162 WES S A GGS FT VRT D T - G EPMG RGT KVI LHLKED Q T EYLEERRIKEIVK K H SQFI G YPI T L FV E KERDK EV sddeaeeked 240
Cdd:PTZ00130 211 WES T A DAK FT IYK D P r G STLK RGT RIS LHLKED A T NLMNDKKLVDLIS K Y SQFI Q YPI Y L LH E NVYTE EV ---------- 280
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 241 keeekekee KESED K PEIE D VGS D EEEEKKDG D KK KK KKIK EK YIDQEE L - N KT KPIW T R N P DDI T N E E Y GE F YKS L TND 319
Cdd:PTZ00130 281 --------- LADIA K EMEN D PNY D SVKVEETD D PN KK TRTV EK KVKKWK L m N EQ KPIW L R P P KEL T D E D Y KK F FSV L SGF 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 320 WEDH L AVK HF SV EG QL EF RA L LFV P R RAP FDLFENRK K K N N IKLYVRRV FIM D NCE E LI P E Y LN F IR GVVDS E DLPLN I S 399
Cdd:PTZ00130 352 NDEP L YHI HF FA EG EI EF KC L IYI P S RAP SINDHLFT K Q N S IKLYVRRV LVA D EFV E FL P R Y MS F VK GVVDS D DLPLN V S 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 400 RE M LQQ S KILK VIR K NL V K K C L E ---- L FT E LAED KE N -------------------------- YK KF Y EQFS K NI K L G I 449
Cdd:PTZ00130 432 RE Q LQQ N KILK AVS K RI V R K I L D tfrt L YK E GKKN KE T lraelaketdeekkkeiqkkinepst YK LI Y KEYR K YL K T G C 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 450 H ED SQ NR K K LSE LL RYY T SAS g DEMV SL KD Y CTR MK EN QK H IYY IT G ETKDQVANSAFVERLR K HGLE V IYMI E PI DE Y C 529
Cdd:PTZ00130 512 Y ED DI NR N K IVK LL LFK T MLH - PKSI SL DT Y IEN MK PD QK F IYY AS G DSYEYLSKIPQLQIFK K KNID V VFLT E SV DE S C 590
570
....*....|....*..
gi 83318444 530 VQ QLK E FE GK TLV S VT K 546
Cdd:PTZ00130 591 VQ RVQ E YD GK KFK S IQ K 607
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214
9.34e-114
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 336.42
E-value: 9.34e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 28 QL MS LII NTF YSNKEIFLRELISN S SDALDK I RY E SLTDPS K LD SGK EL H I NLI P N K QD RTLTI V DTGIGMTK AD LINNL 107
Cdd:cd16927 2 QL LD LII HSL YSNKEIFLRELISN A SDALDK L RY L SLTDPS L LD DDP EL E I RIS P D K EN RTLTI S DTGIGMTK EE LINNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 108 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSA YL VA E KVTV I TK HN - DDE Q Y A WES SA GGS F T VRTDT GE P m GRGTK 185
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSA FM VA D KVTV T TK SA g DDE G Y R WES DG GGS Y T IEEAE GE L - GRGTK 160
170 180
....*....|....*....|....*....
gi 83318444 186 VI LHLKED QT E Y LEE R RIKE I VKK H S Q FI 214
Cdd:cd16927 161 IT LHLKED AK E F LEE A RIKE L VKK Y S D FI 189
PRK14083
PRK14083 HSP90 family protein; Provisional
21-416
1.21e-32
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 132.76
E-value: 1.21e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 21 A FQ AEIAQLMS L IINTF YS NKEIFL REL IS N SS DA ldk I RYESLT DP S kl DS G K e LH I N L i PNKQDR TL TIV D T GIG M T K 100
Cdd:PRK14083 4 R FQ VDLRGVID L LSRHL YS SPRVYV REL LQ N AV DA --- I TARRAL DP T -- AP G R - IR I E L - TDAGGG TL IVE D N GIG L T E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 101 ADLINN L G TI AK S GTKA fm E A L QAGAD i SMI GQFG V G FY S AY LVA EKVT V ITKHND D EQ - YA W ESS A G G SFT VR TDTG E P 179
Cdd:PRK14083 77 EEVHEF L A TI GR S SKRD -- E N L GFARN - DFL GQFG I G LL S CF LVA DEIV V VSRSAK D GP a VE W RGK A D G TYS VR KLET E R 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 180 MGR GT K V I L HLKE D QT E Y LE ERRIK E IV KK HSQFIGY PI TLFV EK ER dkevsddeaeekedkeeekekeekesedkpeie 259
Cdd:PRK14083 154 AEP GT T V Y L RPRP D AE E W LE RETVE E LA KK YGSLLPV PI RVEG EK GG --------------------------------- 200
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 260 dvgsdeeeekkdgdkkkkkkikekyidqee L N K T K P I WTR NPD D ITNE ----- E YGE fy KS L TNDWE D H -- L A V KHFSV E 332
Cdd:PRK14083 201 ------------------------------ V N E T P P P WTR DYP D PETR reall A YGE -- EL L GFTPL D V ip L D V PSGGL E 248
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 333 G qlefra LLF V - P RRAPF dlfe NRKK K N ni KL Y VR R VFIMDNC E E L I P EYLN F I R G VV DSED L PLNI SRE M L QQSKI L KV 411
Cdd:PRK14083 249 G ------ VAY V l P YAVSP ---- AARR K H -- RV Y LK R MLLSEEA E N L L P DWAF F V R C VV NTDE L RPTA SRE A L YEDDA L AA 316
....*
gi 83318444 412 I R KN L 416
Cdd:PRK14083 317 V R EE L 321
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191
1.12e-11
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 61.90
E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 40 NKEIF LR ELI SN SS D ALD K IRY E sltdpsklds G KELHIN L IPNKQDRTL T IV D T G I G MTKA DL innlgtiaksg T K A F M 119
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTP E ---------- G GRITVT L ERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83318444 120 EALQAGADISM IG QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SFT V RTDT gepm G R GT KVILH L K 191
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLV E LH ------------------ GG EIS V ESEP ---- G G GT TFTIT L P 109
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
42-159
3.85e-09
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 55.03
E-value: 3.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 42 E IF L R ELI S NS S DA ldkiryesltdpskld SGKELH I NLIP N KQDR T - LT I V D T G I GM TKAD LIN N L G t I A K S GTK afme 120
Cdd:pfam13589 2 E GA L A ELI D NS I DA ---------------- DATNIK I EVNK N RGGG T e IV I E D D G H GM SPEE LIN A L R - L A T S AKE ---- 60
90 100 110 120
....*....|....*....|....*....|....*....|
gi 83318444 121 alq A GADISMI G QF G V G FYS A Y L V - AE K V TV IT K HNDDEQ 159
Cdd:pfam13589 61 --- A KRGSTDL G RY G I G LKL A S L S l GA K L TV TS K KEGKSS 97
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
40-194
8.70e-06
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 45.05
E-value: 8.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83318444 40 NK E IF LR ELI SN SS D ALD K IRYE sltdpsklds GK E LHIN L IP n KQDR TLT IV D T GIG MTKA DL innlgti AKSGTK a F M 119
Cdd:pfam02518 1 GD E LR LR QVL SN LL D NAL K HAAK ---------- AG E ITVT L SE - GGEL TLT VE D N GIG IPPE DL ------- PRIFEP - F S 61
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 83318444 120 E alqag AD ISMI G QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SF TV RTDT gepm G R GT K V I L H L KED Q 194
Cdd:pfam02518 62 T ----- AD KRGG G GT G L G LSIVRKLV E LL ------------------ GG TI TV ESEP ---- G G GT T V T L T L PLA Q 109
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
