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Conserved domains on  [gi|30583443|gb|AAP35966|]
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3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) [Homo sapiens]

Protein Classification

hydroxymethylglutaryl-CoA synthase family protein( domain architecture ID 11493194)

hydroxymethylglutaryl-CoA (HMG-CoA) synthase family protein such as HMG-CoA synthase that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HMG-CoA-S_euk TIGR01833
3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; Hydroxymethylglutaryl(HMG)-CoA ...
13-469 0e+00

3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; Hydroxymethylglutaryl(HMG)-CoA synthase is the first step of isopentenyl pyrophosphate (IPP) biosynthesis via the mevalonate pathway. This pathway is found mainly in eukaryotes, but also in archaea and some bacteria. This model is specific for eukaryotes.


:

Pssm-ID: 273826 [Multi-domain]  Cd Length: 457  Bit Score: 947.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    13 WPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEV 92
Cdd:TIGR01833   1 WPKDVGILALEIYFPSQYVDQAELEKYDGVSAGKYTIGLGQTKMGFCTDREDINSLCLTVVSKLMERYNIDYDQIGRLEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    93 GTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTG 172
Cdd:TIGR01833  81 GTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAALFNAINWIESSSWDGRYALVVAGDIAVYAKGNARPTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   173 GVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKD 252
Cdd:TIGR01833 161 GAGAVAMLIGPNAPIVFERGLRGSHMQHAYDFYKPDLASEYPVVDGKLSIQCYLSALDRCYKSYCKKIEKQWGKSGSDRK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   253 FTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Cdd:TIGR01833 241 FTLDDFDYMIFHSPYCKLVQKSLARLLYNDFLRNPSSTDTSLYEGLEALSGLKLEDTYTDRDLEKAFMKASKELFDKKTK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRL 412
Cdd:TIGR01833 321 PSLLVPTQVGNMYTASLYGCLASLLSSKSAQELAGKRVGMFSYGSGLAASMFSLRVSQDASPGSALDKLIASLSDLKNRL 400
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30583443   413 DSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Cdd:TIGR01833 401 DSRHCVAPEEFEETMELREQAHHKKNFTPQGSIDSLFPGTWYLERVDSKHRRSYARK 457
 
Name Accession Description Interval E-value
HMG-CoA-S_euk TIGR01833
3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; Hydroxymethylglutaryl(HMG)-CoA ...
13-469 0e+00

3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; Hydroxymethylglutaryl(HMG)-CoA synthase is the first step of isopentenyl pyrophosphate (IPP) biosynthesis via the mevalonate pathway. This pathway is found mainly in eukaryotes, but also in archaea and some bacteria. This model is specific for eukaryotes.


Pssm-ID: 273826 [Multi-domain]  Cd Length: 457  Bit Score: 947.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    13 WPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEV 92
Cdd:TIGR01833   1 WPKDVGILALEIYFPSQYVDQAELEKYDGVSAGKYTIGLGQTKMGFCTDREDINSLCLTVVSKLMERYNIDYDQIGRLEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    93 GTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTG 172
Cdd:TIGR01833  81 GTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAALFNAINWIESSSWDGRYALVVAGDIAVYAKGNARPTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   173 GVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKD 252
Cdd:TIGR01833 161 GAGAVAMLIGPNAPIVFERGLRGSHMQHAYDFYKPDLASEYPVVDGKLSIQCYLSALDRCYKSYCKKIEKQWGKSGSDRK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   253 FTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Cdd:TIGR01833 241 FTLDDFDYMIFHSPYCKLVQKSLARLLYNDFLRNPSSTDTSLYEGLEALSGLKLEDTYTDRDLEKAFMKASKELFDKKTK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRL 412
Cdd:TIGR01833 321 PSLLVPTQVGNMYTASLYGCLASLLSSKSAQELAGKRVGMFSYGSGLAASMFSLRVSQDASPGSALDKLIASLSDLKNRL 400
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30583443   413 DSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Cdd:TIGR01833 401 DSRHCVAPEEFEETMELREQAHHKKNFTPQGSIDSLFPGTWYLERVDSKHRRSYARK 457
PLN02577 PLN02577
hydroxymethylglutaryl-CoA synthase
14-474 0e+00

hydroxymethylglutaryl-CoA synthase


Pssm-ID: 178189 [Multi-domain]  Cd Length: 459  Bit Score: 627.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   14 PKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVG 93
Cdd:PLN02577   2 PKNVGILAMEVYFPPTCVQQEALEAHDGVSKGKYTIGLGQDCMAFCTDVEDVISMSLTVVKSLLEKYNIDPKQIGRLEVG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   94 TETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGG 173
Cdd:PLN02577  82 SETVIDKSKSIKTFLMQLFEESGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVAADSAVYAEGPARPTGG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  174 VGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIhaqwqKEGNDKDF 253
Cdd:PLN02577 162 AGAVAMLVGPNAPIVFESKYRGSHMAHVYDFYKPDLASEYPVVDGKLSQTCYLMALDSCYKRFCEKY-----EKLEGKQF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  254 TLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKA 333
Cdd:PLN02577 237 SISDADYFVFHAPYNKLVQKSFARLVYNDFQRNASSVDEDAKEKLAPFAGLSSDESYQNRDLEKVSQQVAKPLYDAKVQP 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  334 SLLVSNQNGNMYTSSVYGSLASVLAQYSpQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSaLDKItASLCDLKSRLD 413
Cdd:PLN02577 317 TTLIPKQVGNMYTASLYAALASLVHNKH-SELAGKRILMFSYGSGLTATMFSLRLHEGQHPFS-LSNI-AKVMDVSEKLK 393
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30583443  414 SRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPND 474
Cdd:PLN02577 394 SRHEVSPEKFVETLKLMEHRYGAKDFVPSKDVSLLAPGTYYLTEVDSLYRRFYDRKALNGS 454
HMG_CoA_synt_C pfam08540
Hydroxymethylglutaryl-coenzyme A synthase C terminal;
187-469 1.46e-166

Hydroxymethylglutaryl-coenzyme A synthase C terminal;


Pssm-ID: 400722  Cd Length: 280  Bit Score: 472.34  E-value: 1.46e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   187 LIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKegNDKDFTLNDFGFMIFHSP 266
Cdd:pfam08540   1 IVFDRGLRGSHMEHAYDFYKPDLTSEYPVVDGKLSLSCYLKALDRCYKNYRKKINRITKD--GDKIFGLNDFDYMIFHSP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   267 YCKLVQKSLARMLLNDFLNDQNRDK-NSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMY 345
Cdd:pfam08540  79 TCKLVQKSLARLLYNDFLSNPSSDKfNGVDEKLTAFGGLTLDESYTDKDLEKAFMKLSKPFFKKKVQPSLLVPTNNGNMY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   346 TSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDkiTASLCDLKSRLDSRTGVAPDVFAE 425
Cdd:pfam08540 159 TASLYAALASLLSHVSADDLAGKRIGAFSYGSGLAATLFSLRVKQDVSPGSILD--IASVLDLGKRLDSRICVTPEEFTE 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 30583443   426 NMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Cdd:pfam08540 237 AMELREQAHLKKNFKPQGSIDSLFPGTYYLTNVDDKFRRSYARK 280
init_cond_enzymes cd00827
"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
16-386 1.36e-90

"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.


Pssm-ID: 238423 [Multi-domain]  Cd Length: 324  Bit Score: 280.09  E-value: 1.36e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCtdREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTE 95
Cdd:cd00827   1 DVGIEAIGAYLPRYRVDNEELAEGLGVDPGKYTTGIGQRHMAGD--DEDVPTMAVEAARRALERAGIDPDDIGLLIVATE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  96 TIIDKSKSVKTnlmQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWdgRYALVVAGDIAVYAT---GNARPTG 172
Cdd:cd00827  79 SPIDKGKSAAT---YLAELLGLTNAEAFDLKQACYGGTAALQLAANLVESGPW--RYALVVASDIASYLLdegSALEPTL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 173 GVGAVALLIGPNAPlIFERGLRGTHMQHAYDFYKpdmlSEYPIVDGKLSIQCYlsaldrcysvYCKKIHAQWQKEGndkd 252
Cdd:cd00827 154 GDGAAAMLVSRNPG-ILAAGIVSTHSTSDPGYDF----SPYPVMDGGYPKPCK----------LAYAIRLTAEPAG---- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 253 ftlnDFGFMIFHSPYCKLVQKSLARMLLN---DFLNDQNRDKNSIYSGLEAfgdvKLEDTYFdrdvekafmKASSELFSq 329
Cdd:cd00827 215 ----RAVFEAAHKLIAKVVRKALDRAGLSediDYFVPHQPNGKKILEAVAK----KLGGPPE---------KASQTRWI- 276
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30583443 330 ktkasllVSNQNGNMYTSSVYGSLASVLAQYSPQqlAGKRIGVFSYGSGLAATLYSL 386
Cdd:cd00827 277 -------LLRRVGNMYAASILLGLASLLESGKLK--AGDRVLLFSYGSGFTAEAFVL 324
PksG COG3425
3-hydroxy-3-methylglutaryl CoA synthase [Lipid transport and metabolism]; ...
17-467 1.64e-82

3-hydroxy-3-methylglutaryl CoA synthase [Lipid transport and metabolism]; 3-hydroxy-3-methylglutaryl CoA synthase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442651 [Multi-domain]  Cd Length: 382  Bit Score: 261.27  E-value: 1.64e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDInsLCMTV--VQNLMERNNLSYDCIGRLEVGT 94
Cdd:COG3425   3 VGIDAIGFYIPRYRLDLEELAEARGVDPEKYTKGLGQEEKSVPPPDEDA--VTMAAnaARRALDRAGIDPSDIGAVYVGT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  95 ETIIDKSKSVKTNLMQLFEESGNTDieGIDTTNACYGGTAAVFNAVNWIESSSwdGRYALVVAGDIAVYATGNA-RPTGG 173
Cdd:COG3425  81 ESGPDASKPIATYVHGALGLPPNCR--AFELKFACYAGTAALQAALGWVASGP--NKKALVIASDIARYGPGSAgEYTQG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 174 VGAVALLIGPNaPLIFE-RGLRGTHMQHAYDFYKPDmLSEYPIVDGKLSIQCYLSALDRCYsvyckkihAQWQKEGNDKd 252
Cdd:COG3425 157 AGAVAMLVGAD-PRIAEiEGGSGSYTTDVMDFWRPN-GSDYPLVDGRFSEPAYLDHLEEAV--------KDYKEKTGLK- 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 253 ftLNDFGFMIFHSPYCKLVQKsLARMLLNDFLndqnrdknsiysgleafgdvkledtyfdrdvekafmKASSELFSQKTK 332
Cdd:COG3425 226 --PDDFDYFVFHQPFGKMPKK-AAKKLGRKAG------------------------------------REIQEDFEEQVE 266
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPqqLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLcDLKSRL 412
Cdd:COG3425 267 PSLIYSRRIGNTYTGSLYLGLASLLDNAKD--LPGDRIGLFSYGSGAGSEFFSGTVTPGIEERLRRPGVEEQL-ANRRYL 343
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30583443 413 DsrtgvapdvFAENMKLREDThhlvnyIPQGSIDSLFEGTWYLVRVDEkHRRTYA 467
Cdd:COG3425 344 S---------YAEYEKLRGKI------LPEDAEDVTLPGEFVLTGIKD-HERIYE 382
 
Name Accession Description Interval E-value
HMG-CoA-S_euk TIGR01833
3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; Hydroxymethylglutaryl(HMG)-CoA ...
13-469 0e+00

3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; Hydroxymethylglutaryl(HMG)-CoA synthase is the first step of isopentenyl pyrophosphate (IPP) biosynthesis via the mevalonate pathway. This pathway is found mainly in eukaryotes, but also in archaea and some bacteria. This model is specific for eukaryotes.


Pssm-ID: 273826 [Multi-domain]  Cd Length: 457  Bit Score: 947.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    13 WPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEV 92
Cdd:TIGR01833   1 WPKDVGILALEIYFPSQYVDQAELEKYDGVSAGKYTIGLGQTKMGFCTDREDINSLCLTVVSKLMERYNIDYDQIGRLEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    93 GTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTG 172
Cdd:TIGR01833  81 GTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACYGGTAALFNAINWIESSSWDGRYALVVAGDIAVYAKGNARPTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   173 GVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKD 252
Cdd:TIGR01833 161 GAGAVAMLIGPNAPIVFERGLRGSHMQHAYDFYKPDLASEYPVVDGKLSIQCYLSALDRCYKSYCKKIEKQWGKSGSDRK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   253 FTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTK 332
Cdd:TIGR01833 241 FTLDDFDYMIFHSPYCKLVQKSLARLLYNDFLRNPSSTDTSLYEGLEALSGLKLEDTYTDRDLEKAFMKASKELFDKKTK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRL 412
Cdd:TIGR01833 321 PSLLVPTQVGNMYTASLYGCLASLLSSKSAQELAGKRVGMFSYGSGLAASMFSLRVSQDASPGSALDKLIASLSDLKNRL 400
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30583443   413 DSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Cdd:TIGR01833 401 DSRHCVAPEEFEETMELREQAHHKKNFTPQGSIDSLFPGTWYLERVDSKHRRSYARK 457
PLN02577 PLN02577
hydroxymethylglutaryl-CoA synthase
14-474 0e+00

hydroxymethylglutaryl-CoA synthase


Pssm-ID: 178189 [Multi-domain]  Cd Length: 459  Bit Score: 627.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   14 PKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVG 93
Cdd:PLN02577   2 PKNVGILAMEVYFPPTCVQQEALEAHDGVSKGKYTIGLGQDCMAFCTDVEDVISMSLTVVKSLLEKYNIDPKQIGRLEVG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   94 TETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGG 173
Cdd:PLN02577  82 SETVIDKSKSIKTFLMQLFEESGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVAADSAVYAEGPARPTGG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  174 VGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIhaqwqKEGNDKDF 253
Cdd:PLN02577 162 AGAVAMLVGPNAPIVFESKYRGSHMAHVYDFYKPDLASEYPVVDGKLSQTCYLMALDSCYKRFCEKY-----EKLEGKQF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  254 TLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKA 333
Cdd:PLN02577 237 SISDADYFVFHAPYNKLVQKSFARLVYNDFQRNASSVDEDAKEKLAPFAGLSSDESYQNRDLEKVSQQVAKPLYDAKVQP 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  334 SLLVSNQNGNMYTSSVYGSLASVLAQYSpQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSaLDKItASLCDLKSRLD 413
Cdd:PLN02577 317 TTLIPKQVGNMYTASLYAALASLVHNKH-SELAGKRILMFSYGSGLTATMFSLRLHEGQHPFS-LSNI-AKVMDVSEKLK 393
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30583443  414 SRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPND 474
Cdd:PLN02577 394 SRHEVSPEKFVETLKLMEHRYGAKDFVPSKDVSLLAPGTYYLTEVDSLYRRFYDRKALNGS 454
HMG_CoA_synt_C pfam08540
Hydroxymethylglutaryl-coenzyme A synthase C terminal;
187-469 1.46e-166

Hydroxymethylglutaryl-coenzyme A synthase C terminal;


Pssm-ID: 400722  Cd Length: 280  Bit Score: 472.34  E-value: 1.46e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   187 LIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKegNDKDFTLNDFGFMIFHSP 266
Cdd:pfam08540   1 IVFDRGLRGSHMEHAYDFYKPDLTSEYPVVDGKLSLSCYLKALDRCYKNYRKKINRITKD--GDKIFGLNDFDYMIFHSP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   267 YCKLVQKSLARMLLNDFLNDQNRDK-NSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMY 345
Cdd:pfam08540  79 TCKLVQKSLARLLYNDFLSNPSSDKfNGVDEKLTAFGGLTLDESYTDKDLEKAFMKLSKPFFKKKVQPSLLVPTNNGNMY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   346 TSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDkiTASLCDLKSRLDSRTGVAPDVFAE 425
Cdd:pfam08540 159 TASLYAALASLLSHVSADDLAGKRIGAFSYGSGLAATLFSLRVKQDVSPGSILD--IASVLDLGKRLDSRICVTPEEFTE 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 30583443   426 NMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469
Cdd:pfam08540 237 AMELREQAHLKKNFKPQGSIDSLFPGTYYLTNVDDKFRRSYARK 280
HMG_CoA_synt_N pfam01154
Hydroxymethylglutaryl-coenzyme A synthase N terminal;
14-186 3.12e-125

Hydroxymethylglutaryl-coenzyme A synthase N terminal;


Pssm-ID: 307348 [Multi-domain]  Cd Length: 173  Bit Score: 363.09  E-value: 3.12e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    14 PKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVG 93
Cdd:pfam01154   1 PKDVGILALEIYFPAQYVDQTELEKFDGVEAGKYTIGLGQTRMGFCSDREDINSLCLTVVQKLMERYNLPWDKIGRLEVG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    94 TETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGG 173
Cdd:pfam01154  81 TETIIDKSKSVKSVLMQLFQESGNTDIEGIDTTNACYGGTAALFNAANWIESSSWDGRYALVVCGDIAIYPSGNARPTGG 160
                         170
                  ....*....|...
gi 30583443   174 VGAVALLIGPNAP 186
Cdd:pfam01154 161 AGAVAMLIGPKAP 173
init_cond_enzymes cd00827
"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, ...
16-386 1.36e-90

"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the utlization of CoA substrate primers, as well as the nature of their active site residues.


Pssm-ID: 238423 [Multi-domain]  Cd Length: 324  Bit Score: 280.09  E-value: 1.36e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  16 DVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCtdREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTE 95
Cdd:cd00827   1 DVGIEAIGAYLPRYRVDNEELAEGLGVDPGKYTTGIGQRHMAGD--DEDVPTMAVEAARRALERAGIDPDDIGLLIVATE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  96 TIIDKSKSVKTnlmQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWdgRYALVVAGDIAVYAT---GNARPTG 172
Cdd:cd00827  79 SPIDKGKSAAT---YLAELLGLTNAEAFDLKQACYGGTAALQLAANLVESGPW--RYALVVASDIASYLLdegSALEPTL 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 173 GVGAVALLIGPNAPlIFERGLRGTHMQHAYDFYKpdmlSEYPIVDGKLSIQCYlsaldrcysvYCKKIHAQWQKEGndkd 252
Cdd:cd00827 154 GDGAAAMLVSRNPG-ILAAGIVSTHSTSDPGYDF----SPYPVMDGGYPKPCK----------LAYAIRLTAEPAG---- 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 253 ftlnDFGFMIFHSPYCKLVQKSLARMLLN---DFLNDQNRDKNSIYSGLEAfgdvKLEDTYFdrdvekafmKASSELFSq 329
Cdd:cd00827 215 ----RAVFEAAHKLIAKVVRKALDRAGLSediDYFVPHQPNGKKILEAVAK----KLGGPPE---------KASQTRWI- 276
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30583443 330 ktkasllVSNQNGNMYTSSVYGSLASVLAQYSPQqlAGKRIGVFSYGSGLAATLYSL 386
Cdd:cd00827 277 -------LLRRVGNMYAASILLGLASLLESGKLK--AGDRVLLFSYGSGFTAEAFVL 324
PksG COG3425
3-hydroxy-3-methylglutaryl CoA synthase [Lipid transport and metabolism]; ...
17-467 1.64e-82

3-hydroxy-3-methylglutaryl CoA synthase [Lipid transport and metabolism]; 3-hydroxy-3-methylglutaryl CoA synthase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442651 [Multi-domain]  Cd Length: 382  Bit Score: 261.27  E-value: 1.64e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDInsLCMTV--VQNLMERNNLSYDCIGRLEVGT 94
Cdd:COG3425   3 VGIDAIGFYIPRYRLDLEELAEARGVDPEKYTKGLGQEEKSVPPPDEDA--VTMAAnaARRALDRAGIDPSDIGAVYVGT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  95 ETIIDKSKSVKTNLMQLFEESGNTDieGIDTTNACYGGTAAVFNAVNWIESSSwdGRYALVVAGDIAVYATGNA-RPTGG 173
Cdd:COG3425  81 ESGPDASKPIATYVHGALGLPPNCR--AFELKFACYAGTAALQAALGWVASGP--NKKALVIASDIARYGPGSAgEYTQG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 174 VGAVALLIGPNaPLIFE-RGLRGTHMQHAYDFYKPDmLSEYPIVDGKLSIQCYLSALDRCYsvyckkihAQWQKEGNDKd 252
Cdd:COG3425 157 AGAVAMLVGAD-PRIAEiEGGSGSYTTDVMDFWRPN-GSDYPLVDGRFSEPAYLDHLEEAV--------KDYKEKTGLK- 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 253 ftLNDFGFMIFHSPYCKLVQKsLARMLLNDFLndqnrdknsiysgleafgdvkledtyfdrdvekafmKASSELFSQKTK 332
Cdd:COG3425 226 --PDDFDYFVFHQPFGKMPKK-AAKKLGRKAG------------------------------------REIQEDFEEQVE 266
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443 333 ASLLVSNQNGNMYTSSVYGSLASVLAQYSPqqLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLcDLKSRL 412
Cdd:COG3425 267 PSLIYSRRIGNTYTGSLYLGLASLLDNAKD--LPGDRIGLFSYGSGAGSEFFSGTVTPGIEERLRRPGVEEQL-ANRRYL 343
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30583443 413 DsrtgvapdvFAENMKLREDThhlvnyIPQGSIDSLFEGTWYLVRVDEkHRRTYA 467
Cdd:COG3425 344 S---------YAEYEKLRGKI------LPEDAEDVTLPGEFVLTGIKD-HERIYE 382
HMG-CoA-S_prok TIGR01835
3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; This clade of ...
17-388 5.37e-53

3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; This clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.


Pssm-ID: 213655 [Multi-domain]  Cd Length: 379  Bit Score: 183.80  E-value: 5.37e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    17 VGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYdcIGRLEVGTET 96
Cdd:TIGR01835   1 IGIDKISFFTPQNYLDMTALAEARGVDPEKFHIGIGQKKMAVPPIDEDIVTMAASAAKPILDRNDKQK--IDMVIFGTES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443    97 IIDKSKSVKTNLMQLFEESGNTdiEGIDTTNACYGGTAAVFNAVNWIESSSwdGRYALVVAGDIAVYAT-GNARPTGGVG 175
Cdd:TIGR01835  79 GIDQSKAAAVYVHGLLGLQPFC--RSFELKQACYGATAALQMAKGHVALSP--DRKVLVIASDIAKYGLeSPGEPTQGAG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   176 AVALLIGPNaPLIFERGL-RGTHMQHAYDFYKPDMlSEYPIVDGKLSIQCYLSALDRCYSVYCKKihaqwqkegndKDFT 254
Cdd:TIGR01835 155 AVAMLVSAD-PKLLAINEdSVLYTDDIMDFWRPNY-STTALVDGQYSNEQYLNAFENAWNDYAKR-----------TGLS 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   255 LNDFGFMIFHSPYCKLVQKSLaRMLLNDFLNDQnrdknsiysgleafgdvkledtyfDRDVEKAFMKasselfsqktkaS 334
Cdd:TIGR01835 222 LADFAAFCFHVPFTKMGLKAL-RHILKKNYEDE------------------------DESVQNAYLE------------S 264
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 30583443   335 LLVSNQNGNMYTSSVYGSLASVLAQySPQQLAGKRIGVFSYGSGLAATLYSLKV 388
Cdd:TIGR01835 265 IIYNREVGNLYTGSLYLGLASLLEN-AFEDTTGDKIGLFSYGSGAVAEFFSGTL 317
PRK04262 PRK04262
hypothetical protein; Provisional
15-389 2.21e-07

hypothetical protein; Provisional


Pssm-ID: 235266 [Multi-domain]  Cd Length: 347  Bit Score: 52.99  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLG---QAKMGFctdreDINSLCMTV--VQNLMERNNLSYDCIGR 89
Cdd:PRK04262   1 MMVGIVGYGAYIPRYRIKVEEIARVWGDDPEAIKRGLGveeKSVPGP-----DEDTATIAVeaARNALKRAGIDPKEIGA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443   90 LEVGTETiidKSKSVKTNLMQLFEESGNT-DIEGIDTTNACYGGTAAVFNAVNWIESSSwdGRYALVVAGDiavyaTGNA 168
Cdd:PRK04262  76 VYVGSES---HPYAVKPTATIVAEALGATpDLTAADLEFACKAGTAALQAAMGLVKSGM--IKYALAIGAD-----TAQG 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  169 RP------TGGVGAVALLIGPNAPL-IFErglrgthmqHAY-------DFYKPDmLSEYPIVDGKLSIQcylsaldrcyS 234
Cdd:PRK04262 146 APgdaleyTAAAGGAAFIIGKEEVIaEIE---------ATYsyttdtpDFWRRE-GEPYPRHGGRFTGE----------P 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30583443  235 VYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKsLARMLlndflndqnrdknsiysgleAFGDVKLEDTyfdrd 314
Cdd:PRK04262 206 AYFKHIISAAKGLMEKLGLKPSDYDYAVFHQPNGKFPLR-VAKML--------------------GFTKEQVKPG----- 259
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30583443  315 vekafmkasselfsqktkaslLVSNQNGNMYTSSVYGSLASVLAQYSPqqlaGKRIGVFSYGSGLAATLYSLKVT 389
Cdd:PRK04262 260 ---------------------LLTPYIGNTYSGSALLGLAAVLDVAKP----GDRILVVSFGSGAGSDAFSITVT 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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