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Conserved domains on  [gi|31323393|gb|AAP44069|]
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glucose-6-phosphate dehydrogenase, partial [Streptococcus mitis ATCC 6249]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 1000374)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK05722 super family cl29406
glucose-6-phosphate 1-dehydrogenase; Validated
1-151 2.56e-94

glucose-6-phosphate 1-dehydrogenase; Validated


The actual alignment was detected with superfamily member PRK05722:

Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 281.25  E-value: 2.56e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PRK05722 191 TVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQLLALVAMEPPASLDADSIRD 270
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PRK05722 271 EKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALKLEIDNWRWAGVPF 341
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
1-151 2.56e-94

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 281.25  E-value: 2.56e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PRK05722 191 TVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQLLALVAMEPPASLDADSIRD 270
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PRK05722 271 EKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALKLEIDNWRWAGVPF 341
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
1-151 5.59e-92

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 275.03  E-value: 5.59e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393   1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:COG0364 190 TVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLLQLLCLVAMEPPASLDADAIRD 269
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393  81 EKIKVFKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:COG0364 270 EKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTETFVALKLEIDNWRWAGVPF 340
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
6-151 9.67e-91

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 265.46  E-value: 9.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393     6 FAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKV 85
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31323393    86 FKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPF 146
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
1-151 1.26e-71

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 222.58  E-value: 1.26e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393     1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:TIGR00871 183 TVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLLALVAMEPPVSFDADSIRD 262
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393    81 EKIKVFKNLHQPSEEElkEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:TIGR00871 263 EKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALKLEIDNWRWAGVPF 331
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
1-151 2.56e-94

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 281.25  E-value: 2.56e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PRK05722 191 TVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQLLALVAMEPPASLDADSIRD 270
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PRK05722 271 EKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALKLEIDNWRWAGVPF 341
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
1-151 5.59e-92

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 275.03  E-value: 5.59e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393   1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:COG0364 190 TVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLLQLLCLVAMEPPASLDADAIRD 269
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393  81 EKIKVFKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:COG0364 270 EKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTETFVALKLEIDNWRWAGVPF 340
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
6-151 9.67e-91

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 265.46  E-value: 9.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393     6 FAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKV 85
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31323393    86 FKNLHQPSEEELKEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPF 146
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
2-151 1.46e-74

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 230.17  E-value: 1.46e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    2 IQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAE 81
Cdd:PRK12853 182 VQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQLLALVAMEPPASFDADAVRDE 261
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393   82 KIKVFKNLHQPSEEELkeHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PRK12853 262 KAKVLRAIRPLDPDDV--HTVRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVALKLEIDNWRWAGVPF 329
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
1-151 1.26e-71

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 222.58  E-value: 1.26e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393     1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:TIGR00871 183 TVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLLALVAMEPPVSFDADSIRD 262
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393    81 EKIKVFKNLHQPSEEElkEHFIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:TIGR00871 263 EKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALKLEIDNWRWAGVPF 331
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
3-151 2.03e-54

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 177.92  E-value: 2.03e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    3 QSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEK 82
Cdd:PRK12854 191 QNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHLFQVLAFVAMEPPTALEPDAISEEK 270
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   83 IKVFKNLH--QPSEeelkehFIRGQYrsgkiDGkkyisYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PRK12854 271 NKVFRSMRplDPAE------VVRGQY-----SG-----YRDEPGVAPDSTTETFVALKVWIDNWRWAGVPF 325
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
1-151 1.50e-49

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 166.08  E-value: 1.50e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PTZ00309 237 MVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLLQILALLAMEKPVSLSAEDIRD 316
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLhQPSEeelKEHFIRGQYrSGKIDGKKyISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PTZ00309 317 EKVKVLKCI-EPIK---MEECVLGQY-TASADGSI-PGYLEDEGVPKDSTTPTFAAAVLHINNDRWEGVPF 381
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
1-151 5.59e-43

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 149.01  E-value: 5.59e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PLN02640 268 LVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRN 347
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLHQPSEEELkehfIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PLN02640 348 EKVKVLRSMKPLQLEDV----IVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAAALFINNARWDGVPF 414
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
1-151 4.44e-42

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 147.05  E-value: 4.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PLN02333 297 LVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRN 376
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLHQPSEEELkehfIRGQYRSGKIDGKKYISYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PLN02333 377 EKVKVLRSMRPIQLEDV----VIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPF 443
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
1-151 5.48e-41

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 142.56  E-value: 5.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31323393    1 MIQSIFAVRFANMIFENVWNREHIDNVQITFAERLGVEERGGYYDESGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRA 80
Cdd:PLN02539 201 LVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQVLCLVAMEKPVSLKPEHIRD 280
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31323393   81 EKIKVFKNLHQPSEEELkehfIRGQYrsgkiDGkkyisYRSEPNVNPESTTETFASGAFFVDSDRFRGVPF 151
Cdd:PLN02539 281 EKVKVLQSVEPIKDEEV----VLGQY-----EG-----YRDDPTVPDDSNTPTFASVVLRINNERWEGVPF 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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