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Conserved domains on  [gi|61104911|gb|AAX38250|]
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heat shock protein 90Bb [Homo sapiens]

Protein Classification

HSP90 family protein( domain architecture ID 1903338)

HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction

CATH:  3.30.565.10
Gene Ontology:  GO:0044183|GO:0051082|GO:0034605|GO:0005524
PubMed:  19697319|30401745|36367390
SCOP:  4001945

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSP90 super family cl46693
Hsp90 protein;
54-421 8.57e-99

Hsp90 protein;


The actual alignment was detected with superfamily member PTZ00272:

Pssm-ID: 481033  Cd Length: 701  Bit Score: 309.68  E-value: 8.57e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   54 ETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTGIG 133
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  134 MTKADLINNLGTIAKF---------------------------------------------------------------- 149
Cdd:PTZ00272  83 MTKADLVNNLGTIARSgtkafmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  150 --------------QDQTEYLEEMQVKEVVEKHSQFLGYPITLYLEKEREKEISDgkaeeEKGEKEEENKDDEEKPKIED 215
Cdd:PTZ00272 163 sdmkrgtritlhlkEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTD-----EDEEDTKKADEDGEEPKVEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  216 VgsDEEDDSGKDKKKKTKKIKEKYIDQeelNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKDHLAVRYFSVE-------- 287
Cdd:PTZ00272 238 V--KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEgqlefrsi 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911      --------------------------------------------------------------------------------
Cdd:PTZ00272 313 mfvpkrapfdmfepnkkrnniklyvrrvfimdncedlcpdwlgfvkgvvdsedlplnisrenlqqnkilkvirknivkkc 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  288 ----------------------------------------------------------EYVSRMKEIQKSIYYITGESKE 309
Cdd:PTZ00272 393 lemfdevaenkedykqfyeqfgkniklgihedtanrkklmellrfystesgeemttlkDYVTRMKAGQKSIYYITGDSKK 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  310 QVANSAFVEQVWKRDSRVVYMTEPIDGY---QLKEFDGKSLVSVTKEGLELPEDGEEKKRMEERKAKFENLCKFMKETLD 386
Cdd:PTZ00272 473 KLETSPFIEQARRRGLEVLFMTEPIDEYvmqQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLG 552

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 61104911  387 KKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMK 421
Cdd:PTZ00272 553 DKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMR 587
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
 54-421 8.57e-99

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 309.68  E-value: 8.57e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   54 ETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTGIG 133
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  134 MTKADLINNLGTIAKF---------------------------------------------------------------- 149
Cdd:PTZ00272  83 MTKADLVNNLGTIARSgtkafmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  150 --------------QDQTEYLEEMQVKEVVEKHSQFLGYPITLYLEKEREKEISDgkaeeEKGEKEEENKDDEEKPKIED 215
Cdd:PTZ00272 163 sdmkrgtritlhlkEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTD-----EDEEDTKKADEDGEEPKVEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  216 VgsDEEDDSGKDKKKKTKKIKEKYIDQeelNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKDHLAVRYFSVE-------- 287
Cdd:PTZ00272 238 V--KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEgqlefrsi 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911      --------------------------------------------------------------------------------
Cdd:PTZ00272 313 mfvpkrapfdmfepnkkrnniklyvrrvfimdncedlcpdwlgfvkgvvdsedlplnisrenlqqnkilkvirknivkkc 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  288 ----------------------------------------------------------EYVSRMKEIQKSIYYITGESKE 309
Cdd:PTZ00272 393 lemfdevaenkedykqfyeqfgkniklgihedtanrkklmellrfystesgeemttlkDYVTRMKAGQKSIYYITGDSKK 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  310 QVANSAFVEQVWKRDSRVVYMTEPIDGY---QLKEFDGKSLVSVTKEGLELPEDGEEKKRMEERKAKFENLCKFMKETLD 386
Cdd:PTZ00272 473 KLETSPFIEQARRRGLEVLFMTEPIDEYvmqQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLG 552

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 61104911  387 KKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMK 421
Cdd:PTZ00272 553 DKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMR 587
HSP90 pfam00183
Hsp90 protein;
154-422 5.98e-89

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 279.05  E-value: 5.98e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   154 EYLEEMQVKEVVEKHSQFLGYPITLYLEKEREKEISDgkaeEEKGEKEEENKDDEEKPKIEDVGSDEEDdsgkdkkKKTK 233
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPD----EEEEEEEEEEEEEDDDPKVEEEDEEEEK-------KKTK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   234 KIKEKYIDQEELNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKDHLAVRYFSVE-------------------------- 287
Cdd:pfam00183  70 KVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEgevefksllfipkrapfdlfenkkkk 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911       --------------------------------------------------------------------------------
Cdd:pfam00183 150 nniklyvrrvfitddfedlipeylnfvkgvvdsddlplnvsretlqqnkilkvikkklvrkaldmfkeiaeekedykkfw 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   288 ----------------------------------------EYVSRMKEIQKSIYYITGESKEQVANSAFVEQVWKRDSRV 327
Cdd:pfam00183 230 kefgknlklgiiedssnrnklakllrfyssksgdeltsldDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEV 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   328 VYMTEPIDGY---QLKEFDGKSLVSVTKEGLELPEDGEEKKRMEERKAKFENLCKFMKETLDKKVEMVTVSNRLVSSSCC 404
Cdd:pfam00183 310 LYLTDPIDEYavqQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVDSPCV 389

                         410
                  ....*....|....*...
gi 61104911   405 IVTSTYSWTANMEQIMKA 422
Cdd:pfam00183 390 LVTSQYGWSANMERIMKA 407
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
 52-422 4.39e-80

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 258.51  E-value: 4.39e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  52 EVETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTG 131
Cdd:COG0326   2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 132 IGMTKADLINNLGTIAK-----------------------F--------------------------------------- 149
Cdd:COG0326  82 IGMTREEVIENLGTIAKsgtrefleklkgdqkkdsdligqFgvgfysafmvadkvevvtrsagedaeavrwesdgdgeyt 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 150 ------------------QDQTEYLEEMQVKEVVEKHSQFLGYPItlYLEKEREKEISDgkaeeekgekeeenkddeekp 211
Cdd:COG0326 162 ieeaekaergteitlhlkEDAEEFLEEWRLREIIKKYSDFIPVPI--KMEGEEEETEED--------------------- 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 212 kiedvgsdeeddsgkdkkkktkkikekyidqEELNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKD-----HLAV----- 281
Cdd:COG0326 219 -------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDplfwiHLNVegpfe 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 282 --------------------------------------------------------------R----------------- 282
Cdd:COG0326 268 ytgllyipkkapfdlydrdrkggiklyvkrvfimddaedllpeylrfvrgvvdspdlplnvsReilqedrqlkkirkait 347

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 283 --------------------------------------------------------YFSVEEYVSRMKEIQKSIYYITGE 306
Cdd:COG0326 348 kkvldeleklakndrekyekfwkefglvlkegaledfknrekiadllrfestkeggYVTLAEYVERMKEGQKKIYYITGE 427

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 307 SKEQVANSAFVEQVWKRDSRVVYMTEPIDGY---QLKEFDGKSLVSVTKEGLELpEDGEEKKRMEERKAKFENLCKFMKE 383
Cdd:COG0326 428 SREAAEQSPHLEIFKAKGIEVLLLTDPIDEFlisHLEEFDGKKFKSVDSGDLDL-DKLEEKKESEEEEEEFKPLLERFKE 506

                       570       580       590
                ....*....|....*....|....*....|....*....
gi 61104911 384 TLDKKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMKA 422
Cdd:COG0326 507 ALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA 545
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
 64-148 4.93e-45

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 154.60  E-value: 4.93e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  64 QLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTGIGMTKADLINNL 143
Cdd:cd16927   2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81


                ....*
gi 61104911 144 GTIAK 148
Cdd:cd16927  82 GTIAR 86
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
 54-421 8.57e-99

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 309.68  E-value: 8.57e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   54 ETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTGIG 133
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  134 MTKADLINNLGTIAKF---------------------------------------------------------------- 149
Cdd:PTZ00272  83 MTKADLVNNLGTIARSgtkafmealeaggdmsmigqfgvgfysaylvadrvtvtsknnsdesyvwessaggtftitstpe 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  150 --------------QDQTEYLEEMQVKEVVEKHSQFLGYPITLYLEKEREKEISDgkaeeEKGEKEEENKDDEEKPKIED 215
Cdd:PTZ00272 163 sdmkrgtritlhlkEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTD-----EDEEDTKKADEDGEEPKVEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  216 VgsDEEDDSGKDKKKKTKKIKEKYIDQeelNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKDHLAVRYFSVE-------- 287
Cdd:PTZ00272 238 V--KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEgqlefrsi 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911      --------------------------------------------------------------------------------
Cdd:PTZ00272 313 mfvpkrapfdmfepnkkrnniklyvrrvfimdncedlcpdwlgfvkgvvdsedlplnisrenlqqnkilkvirknivkkc 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  288 ----------------------------------------------------------EYVSRMKEIQKSIYYITGESKE 309
Cdd:PTZ00272 393 lemfdevaenkedykqfyeqfgkniklgihedtanrkklmellrfystesgeemttlkDYVTRMKAGQKSIYYITGDSKK 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  310 QVANSAFVEQVWKRDSRVVYMTEPIDGY---QLKEFDGKSLVSVTKEGLELPEDGEEKKRMEERKAKFENLCKFMKETLD 386
Cdd:PTZ00272 473 KLETSPFIEQARRRGLEVLFMTEPIDEYvmqQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKEVLG 552

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 61104911  387 KKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMK 421
Cdd:PTZ00272 553 DKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMR 587
HSP90 pfam00183
Hsp90 protein;
154-422 5.98e-89

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 279.05  E-value: 5.98e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   154 EYLEEMQVKEVVEKHSQFLGYPITLYLEKEREKEISDgkaeEEKGEKEEENKDDEEKPKIEDVGSDEEDdsgkdkkKKTK 233
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPD----EEEEEEEEEEEEEDDDPKVEEEDEEEEK-------KKTK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   234 KIKEKYIDQEELNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKDHLAVRYFSVE-------------------------- 287
Cdd:pfam00183  70 KVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEgevefksllfipkrapfdlfenkkkk 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911       --------------------------------------------------------------------------------
Cdd:pfam00183 150 nniklyvrrvfitddfedlipeylnfvkgvvdsddlplnvsretlqqnkilkvikkklvrkaldmfkeiaeekedykkfw 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   288 ----------------------------------------EYVSRMKEIQKSIYYITGESKEQVANSAFVEQVWKRDSRV 327
Cdd:pfam00183 230 kefgknlklgiiedssnrnklakllrfyssksgdeltsldDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKGYEV 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   328 VYMTEPIDGY---QLKEFDGKSLVSVTKEGLELPEDGEEKKRMEERKAKFENLCKFMKETLDKKVEMVTVSNRLVSSSCC 404
Cdd:pfam00183 310 LYLTDPIDEYavqQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVDSPCV 389

                         410
                  ....*....|....*...
gi 61104911   405 IVTSTYSWTANMEQIMKA 422
Cdd:pfam00183 390 LVTSQYGWSANMERIMKA 407
PRK05218 PRK05218
heat shock protein 90; Provisional
 52-422 6.69e-82

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 263.13  E-value: 6.69e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   52 EVETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTG 131
Cdd:PRK05218   2 AMETGEFQAEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFEALTDPALYEGDGDLKIRISFDKEARTLTISDNG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  132 IGMTKADLINNLGTIAK---------------------------F----------------------------------- 149
Cdd:PRK05218  82 IGMTREEVIENLGTIAKsgtkefleklkgdqkkdsqligqfgvgFysafmvadkvtvitrsagpaaeavrwesdgegeyt 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  150 ------------------QDQTEYLEEMQVKEVVEKHSQFLGYPItlYLEKErekeisdgkaeeekgekeeenkddeekp 211
Cdd:PRK05218 162 ieeiekeergteitlhlkEDEDEFLDEWRIRSIIKKYSDFIPVPI--KLEKE---------------------------- 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  212 kiedvgsdeeddsgkdkkkktkkikekyiDQEELNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKD-----HLAV----- 281
Cdd:PRK05218 212 -----------------------------EEETINSASALWTRSKSEITDEEYKEFYKHLAHDFDDplfwiHNNVegpfe 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  282 --------------------------------------------------------------R----------------- 282
Cdd:PRK05218 263 ytgllyipkkapfdlfnrdrkgglklyvkrvfimddaeellpeylrfvkgvidsedlplnvsReilqedrvvkkirkait 342

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  283 --------------------------------------------------------YFSVEEYVSRMKEIQKSIYYITGE 306
Cdd:PRK05218 343 kkvldeleklakndrekyekfwkefgpvlkeglyedfanreklakllrfasthegkYVSLAEYVERMKEGQKKIYYITGD 422

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  307 SKEQVANSAFVEQVWKRDSRVVYMTEPIDGY---QLKEFDGKSLVSVTKEGLELP-EDGEEKKRMEERKAKFENLCKFMK 382
Cdd:PRK05218 423 SREAAKNSPHLELFKKKGIEVLLLTDPIDEFwisYLEEFDGKPFKSVARGDLDLGkEDEEEKEEKEEAEEEFKPLLERLK 502

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|
gi 61104911  383 ETLDKKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMKA 422
Cdd:PRK05218 503 EALGDKVKDVRLSHRLTDSPACLVADEGDMSTQMEKLLKA 542
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
 52-422 4.39e-80

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 258.51  E-value: 4.39e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  52 EVETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTG 131
Cdd:COG0326   2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 132 IGMTKADLINNLGTIAK-----------------------F--------------------------------------- 149
Cdd:COG0326  82 IGMTREEVIENLGTIAKsgtrefleklkgdqkkdsdligqFgvgfysafmvadkvevvtrsagedaeavrwesdgdgeyt 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 150 ------------------QDQTEYLEEMQVKEVVEKHSQFLGYPItlYLEKEREKEISDgkaeeekgekeeenkddeekp 211
Cdd:COG0326 162 ieeaekaergteitlhlkEDAEEFLEEWRLREIIKKYSDFIPVPI--KMEGEEEETEED--------------------- 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 212 kiedvgsdeeddsgkdkkkktkkikekyidqEELNKTKPIWTRNTEDITQEEYGEFYKSLTNDWKD-----HLAV----- 281
Cdd:COG0326 219 -------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDplfwiHLNVegpfe 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 282 --------------------------------------------------------------R----------------- 282
Cdd:COG0326 268 ytgllyipkkapfdlydrdrkggiklyvkrvfimddaedllpeylrfvrgvvdspdlplnvsReilqedrqlkkirkait 347

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 283 --------------------------------------------------------YFSVEEYVSRMKEIQKSIYYITGE 306
Cdd:COG0326 348 kkvldeleklakndrekyekfwkefglvlkegaledfknrekiadllrfestkeggYVTLAEYVERMKEGQKKIYYITGE 427

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911 307 SKEQVANSAFVEQVWKRDSRVVYMTEPIDGY---QLKEFDGKSLVSVTKEGLELpEDGEEKKRMEERKAKFENLCKFMKE 383
Cdd:COG0326 428 SREAAEQSPHLEIFKAKGIEVLLLTDPIDEFlisHLEEFDGKKFKSVDSGDLDL-DKLEEKKESEEEEEEFKPLLERFKE 506

                       570       580       590
                ....*....|....*....|....*....|....*....
gi 61104911 384 TLDKKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMKA 422
Cdd:COG0326 507 ALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA 545
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
 64-148 4.93e-45

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 154.60  E-value: 4.93e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  64 QLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNTQEHTLTLVDTGIGMTKADLINNL 143
Cdd:cd16927   2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81


                ....*
gi 61104911 144 GTIAK 148
Cdd:cd16927  82 GTIAR 86
PTZ00130 PTZ00130
heat shock protein 90; Provisional
 44-421 1.25e-28

heat shock protein 90; Provisional


Pssm-ID: 185466 [Multi-domain]  Cd Length: 814  Bit Score: 118.61  E-value: 1.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   44 EEVHLGEK---EVETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNT 120
Cdd:PTZ00130  53 PEIEDGEKptsGIEQHQYQTEVTRLMDIIVNSLYTQKEVFLRELISNAADALEKIRFLSLSDESVLGEEKKLEIRISANK 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  121 QEHTLTLVDTGIGMTKADLINNLGTIAKF--------------------------------------------------- 149
Cdd:PTZ00130 133 EKNILSITDTGIGMTKEDLINNLGTIAKSgtsnfleaisksggdmsligqfgvgfysaflvadkvivytknnndeqyiwe 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  150 -----------------------------QDQTEYLEEMQVKEVVEKHSQFLGYPITLYLEKEREKEIsdgkaeeekgeK 200
Cdd:PTZ00130 213 stadakftiykdprgstlkrgtrislhlkEDATNLMNDKKLVDLISKYSQFIQYPIYLLHENVYTEEV-----------L 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  201 EEENKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIdqeeLNKTKPIWTRNTEDITQEEYGEFYKSLT--ND---- 274
Cdd:PTZ00130 282 ADIAKEMENDPNYDSVKVEETDDPNKKTRTVEKKVKKWKL----MNEQKPIWLRPPKELTDEDYKKFFSVLSgfNDeply 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  275 ------------------------WKDHLAVRYFSVEEYVSR-------------------------------------- 292
Cdd:PTZ00130 358 hihffaegeiefkcliyipsrapsINDHLFTKQNSIKLYVRRvlvadefveflprymsfvkgvvdsddlplnvsreqlqq 437

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911      --------------------------------------------------------------------------------
Cdd:PTZ00130 438 nkilkavskrivrkildtfrtlykegkknketlraelaketdeekkkeiqkkinepstykliykeyrkylktgcyeddin 517

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911  293 ---------------------------MKEIQKSIYYITGESKEQVANSAFVEQVWKRDSRVVYMTEPIDG---YQLKEF 342
Cdd:PTZ00130 518 rnkivklllfktmlhpksisldtyienMKPDQKFIYYASGDSYEYLSKIPQLQIFKKKNIDVVFLTESVDEscvQRVQEY 597

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61104911  343 DGKSLVSVTKEGLELPEDGEEKKRMEERKAKFENLCKFMKETLDKKVEMVTVSNRLVSSSCCIVTSTYSWTANMEQIMK 421
Cdd:PTZ00130 598 DGKKFKSIQKGEITFELTEDEKKKEEKVKKMYKALIDVISDTLRNQIFKVEISRRLVDAPCAVVSTEWGLSGQMEKLMK 676
PRK14083 PRK14083
HSP90 family protein; Provisional
 57-147 5.71e-07

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 51.87  E-value: 5.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61104911   57 AFQAEIAQLMSLIINTFYSNKEIFLWELISNASDAldkIRYESLTDPSkldsgKELKIDIIP-NTQEHTLTLVDTGIGMT 135
Cdd:PRK14083   4 RFQVDLRGVIDLLSRHLYSSPRVYVRELLQNAVDA---ITARRALDPT-----APGRIRIELtDAGGGTLIVEDNGIGLT 75

                         90
                 ....*....|..
gi 61104911  136 KADLINNLGTIA 147
Cdd:PRK14083  76 EEEVHEFLATIG 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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