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Conserved domains on  [gi|81175398|gb|ABB59038|]
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variable lymphocyte receptor B [Eptatretus stoutii]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183373)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 162-283 5.61e-65

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


:

Pssm-ID: 288750  Cd Length: 122  Bit Score: 199.41  E-value: 5.61e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   162 TCPGIRYFSEWINKHSGVVRDSSDNVNPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVP 241
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYVDPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 81175398   242 PEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 283
Cdd:pfam11921  81 PEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-157 1.18e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.18e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  33 TTVYCHDRSLTSVPTGIPAST--TYLSLADNKLQSLPNgVFDKLTSLTYLNLYNNKLQSLPNgVFDKLTSLTHLDLHTNK 110
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81175398 111 LQSLPDGvFDKLTQLKELSVRNNQLKSVPDgiFDRLTSLQYIRLYTN 157
Cdd:COG4886 217 LTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 162-283 5.61e-65

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 199.41  E-value: 5.61e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   162 TCPGIRYFSEWINKHSGVVRDSSDNVNPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVP 241
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYVDPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 81175398   242 PEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 283
Cdd:pfam11921  81 PEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-157 1.18e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.18e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  33 TTVYCHDRSLTSVPTGIPAST--TYLSLADNKLQSLPNgVFDKLTSLTYLNLYNNKLQSLPNgVFDKLTSLTHLDLHTNK 110
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81175398 111 LQSLPDGvFDKLTQLKELSVRNNQLKSVPDgiFDRLTSLQYIRLYTN 157
Cdd:COG4886 217 LTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
54-111 2.77e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.77e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 81175398    54 TYLSLADNKLQSLPNGVFDKLTSLTYLNLYNNKLQSLPNGVFDKLTSLTHLDLHTNKL 111
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-150 1.45e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 1.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  54 TYLSLADNKLQSLPNgvFDKLTSLTYLNLYNNKLQSLPNgvFDKLTSLTHLDLHTNKLQSLPDgvFDKLTQLKELSVRNN 133
Cdd:cd21340   5 THLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                        90
                ....*....|....*..
gi 81175398 134 QLkSVPDGiFDRLTSLQ 150
Cdd:cd21340  79 RI-SVVEG-LENLTNLE 93
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-55 1.09e-09

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 52.71  E-value: 1.09e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 81175398     23 ACPSRCSCSGTTVYCHDRSLTSVPTGIPASTTY 55
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-157 5.44e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 5.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   28 CSCSGTTVYCHDR-SLTSVPTGIPASTTYLSLADNKLQSLPNGVFDKLTSLtYLNlyNNKLQSLPNGVFDkltSLTHLDL 106
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTL-YAN--SNQLTSIPATLPD---TIQEMEL 248

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 81175398  107 HTNKLQSLPDGVfdkLTQLKELSVRNNQLKSVPDGIFDrltSLQYIRLYTN 157
Cdd:PRK15370 249 SINRITELPERL---PSALQSLDLFHNKISCLPENLPE---ELRYLSVYDN 293
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 130-198 6.25e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.30  E-value: 6.25e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81175398    130 VRNNQLKSVPDGIFDRLTSLQYIRLYTNPWDCTCpGIRYFSEWINKHSGVVRdssdnvNPDSAKCSGSG 198
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVR------QPEAALCAGPG 63
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 162-283 5.61e-65

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 199.41  E-value: 5.61e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   162 TCPGIRYFSEWINKHSGVVRDSSDNVNPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVP 241
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYVDPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 81175398   242 PEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 283
Cdd:pfam11921  81 PEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-157 1.18e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.18e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  33 TTVYCHDRSLTSVPTGIPAST--TYLSLADNKLQSLPNgVFDKLTSLTYLNLYNNKLQSLPNgVFDKLTSLTHLDLHTNK 110
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81175398 111 LQSLPDGvFDKLTQLKELSVRNNQLKSVPDgiFDRLTSLQYIRLYTN 157
Cdd:COG4886 217 LTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-157 2.91e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 2.91e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  54 TYLSLADNKLQSLPNGvFDKLTSLTYLNLYNNKLQSLPNgVFDKLTSLTHLDLHTNKLQSLPDgVFDKLTQLKELSVRNN 133
Cdd:COG4886 116 ESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                        90       100
                ....*....|....*....|....
gi 81175398 134 QLKSVPDGIFdRLTSLQYIRLYTN 157
Cdd:COG4886 193 QITDLPEPLG-NLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-158 2.31e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  68 NGVFDKLTSLTYLNLYNNKLQSLPNGvFDKLTSLTHLDLHTNKLQSLPDgVFDKLTQLKELSVRNNQLKSVPDGIfDRLT 147
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLT 182

                        90
                ....*....|.
gi 81175398 148 SLQYIRLYTNP 158
Cdd:COG4886 183 NLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
54-111 2.77e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.77e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 81175398    54 TYLSLADNKLQSLPNGVFDKLTSLTYLNLYNNKLQSLPNGVFDKLTSLTHLDLHTNKL 111
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
75-135 2.72e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.72e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81175398    75 TSLTYLNLYNNKLQSLPNGVFDKLTSLTHLDLHTNKLQSLPDGVFDKLTQLKELSVRNNQL 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-157 1.79e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  33 TTVYCHDRSLTSVPTGIPAST--TYLSLADNKLQSLPNgvFDKLTSLTYLNLYNNKLQSLPNGVfdKLTSLTHLDLHTNK 110
Cdd:COG4886 208 EELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 81175398 111 LQSLPDGVFDKLTQLKELSVRNNQLKSVPDGIFDRLTSLQYIRLYTN 157
Cdd:COG4886 284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-150 1.45e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 1.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  54 TYLSLADNKLQSLPNgvFDKLTSLTYLNLYNNKLQSLPNgvFDKLTSLTHLDLHTNKLQSLPDgvFDKLTQLKELSVRNN 133
Cdd:cd21340   5 THLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                        90
                ....*....|....*..
gi 81175398 134 QLkSVPDGiFDRLTSLQ 150
Cdd:cd21340  79 RI-SVVEG-LENLTNLE 93
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-55 1.09e-09

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 52.71  E-value: 1.09e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 81175398     23 ACPSRCSCSGTTVYCHDRSLTSVPTGIPASTTY 55
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
99-154 1.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.36e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 81175398    99 TSLTHLDLHTNKLQSLPDGVFDKLTQLKELSVRNNQLKSVPDGIFDRLTSLQYIRL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-157 5.44e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 5.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   28 CSCSGTTVYCHDR-SLTSVPTGIPASTTYLSLADNKLQSLPNGVFDKLTSLtYLNlyNNKLQSLPNGVFDkltSLTHLDL 106
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTL-YAN--SNQLTSIPATLPD---TIQEMEL 248

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 81175398  107 HTNKLQSLPDGVfdkLTQLKELSVRNNQLKSVPDGIFDrltSLQYIRLYTN 157
Cdd:PRK15370 249 SINRITELPERL---PSALQSLDLFHNKISCLPENLPE---ELRYLSVYDN 293
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
20-140 2.14e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.09  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   20 NGKACPSRCSCSGTTVYCHDRSLTSVPTGIPASTTYLSLADNKLQSLPngvfDKLTS-LTYLNLYNNKLQSLPNGVFDKl 98
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFHNKISCLPENLPEE- 284

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 81175398   99 tsLTHLDLHTNKLQSLPDGVFDKLTqlkELSVRNNQLKSVPD 140
Cdd:PRK15370 285 --LRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPE 321
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
35-139 2.17e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.78  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   35 VYCHDRSLTSVPTgIPASTTYLSLADNKLQSLPNgvfdkLTSLTY-LNLYNNKLQSLPNgvfdKLTSLTHLDLHTNKLQS 113
Cdd:PRK15387 327 LWAYNNQLTSLPT-LPSGLQELSVSDNQLASLPT-----LPSELYkLWAYNNRLTSLPA----LPSGLKELIVSGNRLTS 396

                         90       100
                 ....*....|....*....|....*.
gi 81175398  114 LPdgVFDklTQLKELSVRNNQLKSVP 139
Cdd:PRK15387 397 LP--VLP--SELKELMVSGNRLTSLP 418
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-158 8.90e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 8.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398  33 TTVYCHDRSLTSVPT-GIPASTTYLSLADNKLQSLPNgvFDKLTSLTYLNLYNNKLQSLPNgvFDKLTSLTHLDLHTNKL 111
Cdd:cd21340   5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398 112 -------------------QSLPDGV---FD----------------------------KLTQLKELSVRNNQLKSVPD- 140
Cdd:cd21340  81 svveglenltnleelhienQRLPPGEkltFDprslaalsnslrvlnisgnnidsleplaPLRNLEQLDASNNQISDLEEl 160

                       170
                ....*....|....*....
gi 81175398 141 -GIFDRLTSLQYIRLYTNP 158
Cdd:cd21340 161 lDLLSSWPSLRELDLTGNP 179
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-50 3.18e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.70  E-value: 3.18e-07
                          10        20
                  ....*....|....*....|....*...
gi 81175398    23 ACPSRCSCSGTTVYCHDRSLTSVPTGIP 50
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 61-154 6.06e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.84  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398    61 NKLQSLPNGVFDKLTSLTYLNLYNNkLQSLPNGVFDKlTSLTHLDLHTNkLQSLPDGVFDKLTQLKELSVRNNqLKSVPD 140
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                          90
                  ....*....|....
gi 81175398   141 GIFDRlTSLQYIRL 154
Cdd:pfam13306  96 YAFSN-CSLKSITI 108
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
39-139 3.14e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   39 DRSLTSVPTGIPASTTYLSLADNKLQSLP-----------NGvfDKLTSLTY-------LNLYNNKLQSLPNgvfdKLTS 100
Cdd:PRK15387 210 ESGLTTLPDCLPAHITTLVIPDNNLTSLPalppelrtlevSG--NQLTSLPVlppglleLSIFSNPLTHLPA----LPSG 283

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 81175398  101 LTHLDLHTNKLQSLPdgVFDKltQLKELSVRNNQLKSVP 139
Cdd:PRK15387 284 LCKLWIFGNQLTSLP--VLPP--GLQELSVSDNQLASLP 318
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 75-116 3.46e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 3.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 81175398    75 TSLTYLNLYNNKLQSLPNgvFDKLTSLTHLDL-HTNKLQSLPD 116
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLsGNNKITDLSD 41
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-157 3.62e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   34 TVYCHDRSLTSVPTGIPASTTYLSLADNKLQSLPNGVfdkLTSLTYLNLYNNKLQSLPNGVfdkLTSLTHLDLHTNKLQS 113
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITV 360

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 81175398  114 LPDGVFDKLTqlkELSVRNNQLKSVPDGIfdrLTSLQYIRLYTN 157
Cdd:PRK15370 361 LPETLPPTIT---TLDVSRNALTNLPENL---PAALQIMQASRN 398
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
42-139 5.90e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 5.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   42 LTSVPTgIPASTTYLSLADNKLQSLPNgvfdKLTSLTYLNLYNNKLQSLPngvfdkltslthldlhtnklqSLPDGvfdk 121
Cdd:PRK15387 294 LTSLPV-LPPGLQELSVSDNQLASLPA----LPSELCKLWAYNNQLTSLP---------------------TLPSG---- 343

                         90
                 ....*....|....*...
gi 81175398  122 ltqLKELSVRNNQLKSVP 139
Cdd:PRK15387 344 ---LQELSVSDNQLASLP 358
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 130-198 6.25e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.30  E-value: 6.25e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81175398    130 VRNNQLKSVPDGIFDRLTSLQYIRLYTNPWDCTCpGIRYFSEWINKHSGVVRdssdnvNPDSAKCSGSG 198
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVR------QPEAALCAGPG 63
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-178 1.17e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   73 KLTSLTYLNL-YNNKLQSLPNGVFDkLTSLTHLDLHTNKLQ-SLPDGVFDkLTQLKELSVRNNQLKSVPDGIFDRLTSLQ 150
Cdd:PLN00113 234 GLTSLNHLDLvYNNLTGPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLE 311

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 81175398  151 YIRLYTNPWD-------CTCPGIRYFSEWINKHSG 178
Cdd:PLN00113 312 ILHLFSNNFTgkipvalTSLPRLQVLQLWSNKFSG 346
LRR smart00370
Leucine-rich repeats, outliers;
98-120 1.47e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 38.10  E-value: 1.47e-04
                           10        20
                   ....*....|....*....|...
gi 81175398     98 LTSLTHLDLHTNKLQSLPDGVFD 120
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
98-120 1.47e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 38.10  E-value: 1.47e-04
                           10        20
                   ....*....|....*....|...
gi 81175398     98 LTSLTHLDLHTNKLQSLPDGVFD 120
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PLN03150 PLN03150
hypothetical protein; Provisional
 66-167 1.89e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   66 LPNGVfDKLTSLTYLNLYNNKLQSLPNGVFDKLTSLTHLDLHTNKLQ-SLPDGVfDKLTQLKELSVRNNQLKS-VPDGIF 143
Cdd:PLN03150 434 IPNDI-SKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESL-GQLTSLRILNLNGNSLSGrVPAALG 511

                         90       100
                 ....*....|....*....|....
gi 81175398  144 DRLTSLQYIRLYTNPWDCTCPGIR 167
Cdd:PLN03150 512 GRLLHRASFNFTDNAGLCGIPGLR 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-157 3.74e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   52 STTYLSLADNKLQSLPNGVFDKLTSLTYLNLYNNKLQ-SLPNGVFDkLTSLTHLDLHTNklqSLPDGVFDKLTQLKELSV 130
Cdd:PLN00113 237 SLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDN---SLSGEIPELVIQLQNLEI 312

                         90       100       110
                 ....*....|....*....|....*....|.
gi 81175398  131 ----RNNQLKSVPDGIfDRLTSLQYIRLYTN 157
Cdd:PLN00113 313 lhlfSNNFTGKIPVAL-TSLPRLQVLQLWSN 342
LRR smart00370
Leucine-rich repeats, outliers;
74-96 3.82e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 3.82e-04
                           10        20
                   ....*....|....*....|...
gi 81175398     74 LTSLTYLNLYNNKLQSLPNGVFD 96
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
74-96 3.82e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.95  E-value: 3.82e-04
                           10        20
                   ....*....|....*....|...
gi 81175398     74 LTSLTYLNLYNNKLQSLPNGVFD 96
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 42-157 8.29e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 8.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398   42 LTSVPTGIPASTTyLSLADNKLQ-SLPNGVFDKLTSLTYLNLYNNKLQ-SLPNGvfdKLTSLTHLDLHTNKLQ-SLPD-- 116
Cdd:PLN00113  85 ISSAIFRLPYIQT-INLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRG---SIPNLETLDLSNNMLSgEIPNdi 160

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 81175398  117 GVFdklTQLKELSVRNNQLKSVPDGIFDRLTSLQYIRLYTN 157
Cdd:PLN00113 161 GSF---SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN 198
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 54-92 1.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 81175398    54 TYLSLADNKLQSLPNgvFDKLTSLTYLNLY-NNKLQSLPN 92
Cdd:pfam12799   4 EVLDLSNNQITDIPP--LAKLPNLETLDLSgNNKITDLSD 41
LRR smart00370
Leucine-rich repeats, outliers;
122-144 2.04e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.04e-03
                           10        20
                   ....*....|....*....|...
gi 81175398    122 LTQLKELSVRNNQLKSVPDGIFD 144
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
122-144 2.04e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.04e-03
                           10        20
                   ....*....|....*....|...
gi 81175398    122 LTQLKELSVRNNQLKSVPDGIFD 144
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-115 2.52e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 2.52e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81175398  39 DRSLTSvptgIPASTTYLSLADNKLQSLpnGVFDKLTSLTYLNLYNNKLQSLPN--GVFDKLTSLTHLDLHTNKLQSLP 115
Cdd:cd21340 112 PRSLAA----LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PHA03332 PHA03332
membrane glycoprotein; Provisional
 41-168 8.28e-03

membrane glycoprotein; Provisional


Pssm-ID: 223047 [Multi-domain]  Cd Length: 1328  Bit Score: 37.64  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175398    41 SLTSVPTGIPASTTYLSLADNKLQSLPNGVFDKLTSLT--YLNLYNNKLQSL-------PNGVFD----------KLTSL 101
Cdd:PHA03332  316 RVSGFPGECPDVGLELAFNNFGLENLIRTTADRLTILTrgILDIRNNKLNGLvfpwiptPELLDTfqcpgfdgyrHLSYA 395

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81175398   102 THLDLHTNKLQSLPDGVfDKLTQLKELSVRNNQLKSvpdgiFDRLtslQYIRLYTNPWDCTCPGIRY 168
Cdd:PHA03332  396 VRYLLGHMSLEKLTLGV-VVSCQLWGRRVRQYDTNW-----YFQD---NLVTELTTGTDVIYNNMTY 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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