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Conserved domains on  [gi|81175445|gb|ABB59060|]
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variable lymphocyte receptor B [Eptatretus stoutii]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183373)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 186-308 1.98e-63

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


:

Pssm-ID: 288750  Cd Length: 122  Bit Score: 196.33  E-value: 1.98e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   186 SCPGSDYLSRWIQTNKGQVKAKNSWSsDPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLV 265
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYV-DPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 81175445   266 PPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 308
Cdd:pfam11921  80 PPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-182 1.78e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 1.78e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  33 TTVDCESKGLTSVPSGIPSST--TILYPQRNQLQSLPNgVFDKLTQLKDLQLHQNKLQSLPHgVFDKLTQLKELRLYENQ 110
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81175445 111 LQSLPNGvFDKLTELTVLNLDYNKLQSLPhgVFDKLTKLTTLGLPSNQLKSVPDGIfdRLTSLQHIWLSNNP 182
Cdd:COG4886 217 LTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 186-308 1.98e-63

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 196.33  E-value: 1.98e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   186 SCPGSDYLSRWIQTNKGQVKAKNSWSsDPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLV 265
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYV-DPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 81175445   266 PPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 308
Cdd:pfam11921  80 PPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-182 1.78e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 1.78e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  33 TTVDCESKGLTSVPSGIPSST--TILYPQRNQLQSLPNgVFDKLTQLKDLQLHQNKLQSLPHgVFDKLTQLKELRLYENQ 110
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81175445 111 LQSLPNGvFDKLTELTVLNLDYNKLQSLPhgVFDKLTKLTTLGLPSNQLKSVPDGIfdRLTSLQHIWLSNNP 182
Cdd:COG4886 217 LTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
75-135 4.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 4.76e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81175445    75 TQLKDLQLHQNKLQSLPHGVFDKLTQLKELRLYENQLQSLPNGVFDKLTELTVLNLDYNKL 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-181 1.05e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   41 GLTSVPSGIPSSTTILYPQRNQLQSLPNGVFdklTQLKDLQLHQNKLQSLPHGVFDkltQLKELRLYENQLQSLPngvfD 120
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELP----E 258

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81175445  121 KL-TELTVLNLDYNKLQSLPHGVFDkltKLTTLGLPSNQLKSVPDGIfdrLTSLQHIWLSNN 181
Cdd:PRK15370 259 RLpSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSN 314
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-182 1.68e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  33 TTVDCESKGLTSVPS-GIPSSTTILYPQRNQLQSLPNgvFDKLTQLKDLQLHQNK------LQSLPH------------- 92
Cdd:cd21340   5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQiekienLENLVNlkklylggnrisv 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  93 --GvFDKLTQLKELRLyENqlQSLPNGV---FDKLT------ELTVLNLDYNKLQSLphGVFDKLTKLTTLGLPSNQLKS 161
Cdd:cd21340  83 veG-LENLTNLEELHI-EN--QRLPPGEkltFDPRSlaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156

                       170       180
                ....*....|....*....|...
gi 81175445 162 VPD--GIFDRLTSLQHIWLSNNP 182
Cdd:cd21340 157 LEEllDLLSSWPSLRELDLTGNP 179
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-54 5.98e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.08  E-value: 5.98e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 81175445     23 ACPSRCSCSGTTVDCESKGLTSVPSGIPSSTT 54
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-223 1.26e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 1.26e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445    154 LPSNQLKSVPDGIFDRLTSLQHIWLSNNPWDCSCpGSDYLSRWIQtnKGQVKAKNswssdPDSAKCSGSG 223
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDC-GLARLPRWAE--EKGVKVRQ-----PEAALCAGPG 63
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 186-308 1.98e-63

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 196.33  E-value: 1.98e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   186 SCPGSDYLSRWIQTNKGQVKAKNSWSsDPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLV 265
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYV-DPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 81175445   266 PPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 308
Cdd:pfam11921  80 PPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-182 1.78e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 1.78e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  33 TTVDCESKGLTSVPSGIPSST--TILYPQRNQLQSLPNgVFDKLTQLKDLQLHQNKLQSLPHgVFDKLTQLKELRLYENQ 110
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81175445 111 LQSLPNGvFDKLTELTVLNLDYNKLQSLPhgVFDKLTKLTTLGLPSNQLKSVPDGIfdRLTSLQHIWLSNNP 182
Cdd:COG4886 217 LTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-182 8.19e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 8.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  61 NQLQSLPNGVFDKLTQLKDLQLHQNKLqslphgvFDKLTQLKELRLYENQLQSLPNGvFDKLTELTVLNLDYNKLQSLPh 140
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP- 152

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 81175445 141 GVFDKLTKLTTLGLPSNQLKSVPDGIfDRLTSLQHIWLSNNP 182
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
75-135 4.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 4.76e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81175445    75 TQLKDLQLHQNKLQSLPHGVFDKLTQLKELRLYENQLQSLPNGVFDKLTELTVLNLDYNKL 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
99-159 8.57e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 8.57e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81175445    99 TQLKELRLYENQLQSLPNGVFDKLTELTVLNLDYNKLQSLPHGVFDKLTKLTTLGLPSNQL 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
123-182 7.48e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 7.48e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   123 TELTVLNLDYNKLQSLPHGVFDKLTKLTTLGLPSNQLKSVPDGIFDRLTSLQHIWLSNNP 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-181 1.05e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 59.33  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   41 GLTSVPSGIPSSTTILYPQRNQLQSLPNGVFdklTQLKDLQLHQNKLQSLPHGVFDkltQLKELRLYENQLQSLPngvfD 120
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELP----E 258

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81175445  121 KL-TELTVLNLDYNKLQSLPHGVFDkltKLTTLGLPSNQLKSVPDGIfdrLTSLQHIWLSNN 181
Cdd:PRK15370 259 RLpSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSN 314
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-182 1.68e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  33 TTVDCESKGLTSVPS-GIPSSTTILYPQRNQLQSLPNgvFDKLTQLKDLQLHQNK------LQSLPH------------- 92
Cdd:cd21340   5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQiekienLENLVNlkklylggnrisv 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  93 --GvFDKLTQLKELRLyENqlQSLPNGV---FDKLT------ELTVLNLDYNKLQSLphGVFDKLTKLTTLGLPSNQLKS 161
Cdd:cd21340  83 veG-LENLTNLEELHI-EN--QRLPPGEkltFDPRSlaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156

                       170       180
                ....*....|....*....|...
gi 81175445 162 VPD--GIFDRLTSLQHIWLSNNP 182
Cdd:cd21340 157 LEEllDLLSSWPSLRELDLTGNP 179
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
20-181 4.73e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 4.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   20 NGKACPSRCSCSGTTVDCESKGLTSVPSGIPSSTTILYPQRNQLQSLPngvfDKL-TQLKDLQLHQNKLQSLPHGVFDkl 98
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP----ERLpSALQSLDLFHNKISCLPENLPE-- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   99 tQLKELRLYENQLQSLPNGVFDKLTELTVLNldyNKLQSLPHGVfdkLTKLTTLGLPSNQLKSVPDGIfdrLTSLQHIWL 178
Cdd:PRK15370 284 -ELRYLSVYDNSIRTLPAHLPSGITHLNVQS---NSLTALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDV 353


                 ...
gi 81175445  179 SNN 181
Cdd:PRK15370 354 SKN 356
LRRNT smart00013
Leucine rich repeat N-terminal domain;
23-54 5.98e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.08  E-value: 5.98e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 81175445     23 ACPSRCSCSGTTVDCESKGLTSVPSGIPSSTT 54
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRR_8 pfam13855
Leucine rich repeat;
51-111 2.69e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 2.69e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81175445    51 SSTTILYPQRNQLQSLPNGVFDKLTQLKDLQLHQNKLQSLPHGVFDKLTQLKELRLYENQL 111
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-166 3.35e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   34 TVDCESKGLTSVPSGIPSSTTILYPQRNQLQSLPNGVfdkLTQLKDLQLHQNKLQSLPHGVfdkLTQLKELRLYENQLQS 113
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITV 360

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 81175445  114 LPNGVFDKLTELTVlnlDYNKLQSLPHGVfdkLTKLTTLGLPSNQLKSVPDGI 166
Cdd:PRK15370 361 LPETLPPTITTLDV---SRNALTNLPENL---PAALQIMQASRNNLVRLPESL 407
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 23-50 4.86e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.31  E-value: 4.86e-07
                          10        20
                  ....*....|....*....|....*...
gi 81175445    23 ACPSRCSCSGTTVDCESKGLTSVPSGIP 50
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-180 1.71e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  71 FDKLTQLKdlqLHQNKLQSLphGVFDKLTQLKELRLYENQLQSLPNgvFDKLTELTVLNLDYNKLQSLPHgvFDKLTKLT 150
Cdd:cd21340   1 LKRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLK 71

                        90       100       110
                ....*....|....*....|....*....|
gi 81175445 151 TLGLPSNQLkSVPDGiFDRLTSLQHIWLSN 180
Cdd:cd21340  72 KLYLGGNRI-SVVEG-LENLTNLEELHIEN 99
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 154-223 1.26e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 1.26e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445    154 LPSNQLKSVPDGIFDRLTSLQHIWLSNNPWDCSCpGSDYLSRWIQtnKGQVKAKNswssdPDSAKCSGSG 223
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDC-GLARLPRWAE--EKGVKVRQ-----PEAALCAGPG 63
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
28-181 5.98e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.77  E-value: 5.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   28 CSCSGTTV-DCESKGLTSVPSGIPSSTTILYPQRNQLQSLPNgvfdKLTQLKDLQLHQNKLQSLPhgVFDKltQLKELRL 106
Cdd:PRK15387 198 CLNNGNAVlNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA----LPPELRTLEVSGNQLTSLP--VLPP--GLLELSI 269

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81175445  107 YENQLQSLPnGVFDKLTELTVLNLDYNKLQSLPHGvfdkltkLTTLGLPSNQLKSVPdgifDRLTSLQHIWLSNN 181
Cdd:PRK15387 270 FSNPLTHLP-ALPSGLCKLWIFGNQLTSLPVLPPG-------LQELSVSDNQLASLP----ALPSELCKLWAYNN 332
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
42-173 2.87e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   42 LTSVPSgIPSSTTILYPQRNQLQSLPNgvfdKLTQLKDLQLHQNKLQSLPhgvfDKLTQLKELRLYENQLQSLPNgVFDK 121
Cdd:PRK15387 294 LTSLPV-LPPGLQELSVSDNQLASLPA----LPSELCKLWAYNNQLTSLP----TLPSGLQELSVSDNQLASLPT-LPSE 363

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 81175445  122 LTELTVLNLDYNKLQSLPHGVFDKL---TKLTTLG-LPSNQLKSVPDGifDRLTSL 173
Cdd:PRK15387 364 LYKLWAYNNRLTSLPALPSGLKELIvsgNRLTSLPvLPSELKELMVSG--NRLTSL 417
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
42-135 5.18e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   42 LTSVPSgIPSSTTILYPQRNQLQSLPngVFDklTQLKDLQLHQNKLQSLPHgvfdKLTQLKELRLYENQLQSLPNGVFDK 121
Cdd:PRK15387 374 LTSLPA-LPSGLKELIVSGNRLTSLP--VLP--SELKELMVSGNRLTSLPM----LPSGLLSLSVYRNQLTRLPESLIHL 444

                         90
                 ....*....|....
gi 81175445  122 LTELTVlNLDYNKL 135
Cdd:PRK15387 445 SSETTV-NLEGNPL 457
LRR smart00370
Leucine-rich repeats, outliers;
122-144 8.82e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 8.82e-04
                           10        20
                   ....*....|....*....|...
gi 81175445    122 LTELTVLNLDYNKLQSLPHGVFD 144
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
122-144 8.82e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 8.82e-04
                           10        20
                   ....*....|....*....|...
gi 81175445    122 LTELTVLNLDYNKLQSLPHGVFD 144
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR smart00370
Leucine-rich repeats, outliers;
98-120 2.54e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 2.54e-03
                           10        20
                   ....*....|....*....|...
gi 81175445     98 LTQLKELRLYENQLQSLPNGVFD 120
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
98-120 2.54e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 2.54e-03
                           10        20
                   ....*....|....*....|...
gi 81175445     98 LTQLKELRLYENQLQSLPNGVFD 120
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
PLN03150 PLN03150
hypothetical protein; Provisional
 97-189 3.10e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   97 KLTQLKELRLYENQLQSLPNGVFDKLTELTVLNLDYNKLQSLPHGVFDKLTKLTTLGLPSNQLKS-VPDGIFDRLTSLQH 175
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGrVPAALGGRLLHRAS 519

                         90
                 ....*....|....
gi 81175445  176 IWLSNNPWDCSCPG 189
Cdd:PLN03150 520 FNFTDNAGLCGIPG 533
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-135 4.26e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 4.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 81175445    99 TQLKELRLYENQLQSLPNgvFDKLTELTVLNLDYNKL 135
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-181 4.56e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 4.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445  95 FDKLTQLKelrLYENQLQSLPNgvFDKLTELTVLNLDYNKLQSLPHgvFDKLTKLTTLGLPSNQLKSVPDgiFDRLTSLQ 174
Cdd:cd21340   1 LKRITHLY---LNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLK 71


                ....*..
gi 81175445 175 HIWLSNN 181
Cdd:cd21340  72 KLYLGGN 78
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-188 5.21e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175445   76 QLKDLQLHQNKLQSLPHGVFDKLTQLKELRLYENQLQSLPNGVFDKLTELTVLNLDYNKLQSLPHGVFDKLTKLTTLGLP 155
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                         90       100       110
                 ....*....|....*....|....*....|...
gi 81175445  156 SNQLKSVPDGIFDRLTSLQHIWLSNNPWDCSCP 188
Cdd:PLN00113 556 QNQLSGEIPKNLGNVESLVQVNISHNHLHGSLP 588
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 109-181 7.75e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 35.98  E-value: 7.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81175445   109 NQLQSLPNGVFDKLTELTVLNLdYNKLQSLPHGVFDKlTKLTTLGLPSNqLKSVPDGIFDRLTSLQHIWLSNN 181
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITL-PSSLTSIGSYAFYN-CSLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN 89
LRR smart00370
Leucine-rich repeats, outliers;
74-96 8.94e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.09  E-value: 8.94e-03
                           10        20
                   ....*....|....*....|...
gi 81175445     74 LTQLKDLQLHQNKLQSLPHGVFD 96
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
74-96 8.94e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.09  E-value: 8.94e-03
                           10        20
                   ....*....|....*....|...
gi 81175445     74 LTQLKDLQLHQNKLQSLPHGVFD 96
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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