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Conserved domains on  [gi|332803998|gb|AEE99938|]
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vomeronasal type 1 receptor B8 [Mus musculus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11599633)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
11-304 8.50e-153

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


:

Pssm-ID: 320087  Cd Length: 295  Bit Score: 429.38  E-value: 8.50e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  11 TNMKVILSSEVSVGISANSILFISHLCMFLGESRPKPIDIYIAFFSLTHLMRLVTMGLIAVDMFMPGGRWDSTTCTFLMY 90
Cdd:cd13949    1 SNIRITFFSEVGVGISANSILLLFHIFMFFRGHRPRSTDLIIGHLSLIHLLLLLTMGIIATDAFFSWGGWDDITCKFLIY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  91 LHIVLRGPTLCATCLLNVLWTITLSPRNSCLTKFKHKSPHHISGAFLFLCVLYMSLSSELL-TITASLNLTSENFLYVSQ 169
Cdd:cd13949   81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMLISSHLLvSIIATPNLTSNNFIYVTQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998 170 SCSILPMSYSIKSMFSTKMAIREAFLIGLMVLSSGYMVALLWSHKKQAQHLHSTSLSSKASPEQRATRTIMLLMSFFVVF 249
Cdd:cd13949  161 SCSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQHLHSTSLSPKASPEQRATQTILLLMSFFVVM 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 332803998 250 YILDSVIFYSRMKFKDDSIFVCVQIIVSHSYVTVSPFVFICTEKHIIKFFWSLCG 304
Cdd:cd13949  241 YILDSIVFYSRTKFKNDSILYCVQIIVSHSYATVSPFVFLMTEKHIIKFLRSMCG 295
 
Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
11-304 8.50e-153

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


Pssm-ID: 320087  Cd Length: 295  Bit Score: 429.38  E-value: 8.50e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  11 TNMKVILSSEVSVGISANSILFISHLCMFLGESRPKPIDIYIAFFSLTHLMRLVTMGLIAVDMFMPGGRWDSTTCTFLMY 90
Cdd:cd13949    1 SNIRITFFSEVGVGISANSILLLFHIFMFFRGHRPRSTDLIIGHLSLIHLLLLLTMGIIATDAFFSWGGWDDITCKFLIY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  91 LHIVLRGPTLCATCLLNVLWTITLSPRNSCLTKFKHKSPHHISGAFLFLCVLYMSLSSELL-TITASLNLTSENFLYVSQ 169
Cdd:cd13949   81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMLISSHLLvSIIATPNLTSNNFIYVTQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998 170 SCSILPMSYSIKSMFSTKMAIREAFLIGLMVLSSGYMVALLWSHKKQAQHLHSTSLSSKASPEQRATRTIMLLMSFFVVF 249
Cdd:cd13949  161 SCSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQHLHSTSLSPKASPEQRATQTILLLMSFFVVM 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 332803998 250 YILDSVIFYSRMKFKDDSIFVCVQIIVSHSYVTVSPFVFICTEKHIIKFFWSLCG 304
Cdd:cd13949  241 YILDSIVFYSRTKFKNDSILYCVQIIVSHSYATVSPFVFLMTEKHIIKFLRSMCG 295
V1R pfam03402
Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known ...
11-301 4.07e-144

Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known vomeronasal organ receptor families, the V1R family.


Pssm-ID: 460912  Cd Length: 292  Bit Score: 407.49  E-value: 4.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998   11 TNMKVILSSEVSVGISANSILFISHLCMFLGESRPKPIDIYIAFFSLTHLMRLVTMGLIAVDMFMPGGRWDSTTCTFLMY 90
Cdd:pfam03402   1 VNIGIIFFSEVGVGISANSILLLFHIFMFFTGHRLRPTDLIIGHLSLIHLLMLLTMGIIAMDAFGSQGRWDDTTCKFLIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998   91 LHIVLRGPTLCATCLLNVLWTITLSPRNSCLTKFKHKSPHHISGAFLFLCVLYMSLSSELL-TITASLNLTSENFLYVSQ 169
Cdd:pfam03402  81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMSISSHLLlSIIATPNLTSSSFIYVTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  170 SCSILPMSYSIKSMFSTKMAIREAFLIGLMVLSSGYMVALLWSHKKQAQHLHSTSLSSKASPEQRATRTIMLLMSFFVVF 249
Cdd:pfam03402 161 SCSILPMSYSMQSLFSTLLASRDVFLIGLMVLSSGYMVALLCRHKKQAQHLHGTSLSPKASPEQRATRTILLLMSFFVVM 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 332803998  250 YILDSVIFYSRMKFKDDSIFVCVQIIVSHSYVTVSPFVFICTEKHIIKFFWS 301
Cdd:pfam03402 241 YILDSIVSYSRTMFKNDSIFYCVQILVSHSYATVSPFVLISTEKRIIKFLRS 292
 
Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
11-304 8.50e-153

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


Pssm-ID: 320087  Cd Length: 295  Bit Score: 429.38  E-value: 8.50e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  11 TNMKVILSSEVSVGISANSILFISHLCMFLGESRPKPIDIYIAFFSLTHLMRLVTMGLIAVDMFMPGGRWDSTTCTFLMY 90
Cdd:cd13949    1 SNIRITFFSEVGVGISANSILLLFHIFMFFRGHRPRSTDLIIGHLSLIHLLLLLTMGIIATDAFFSWGGWDDITCKFLIY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  91 LHIVLRGPTLCATCLLNVLWTITLSPRNSCLTKFKHKSPHHISGAFLFLCVLYMSLSSELL-TITASLNLTSENFLYVSQ 169
Cdd:cd13949   81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMLISSHLLvSIIATPNLTSNNFIYVTQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998 170 SCSILPMSYSIKSMFSTKMAIREAFLIGLMVLSSGYMVALLWSHKKQAQHLHSTSLSSKASPEQRATRTIMLLMSFFVVF 249
Cdd:cd13949  161 SCSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQHLHSTSLSPKASPEQRATQTILLLMSFFVVM 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 332803998 250 YILDSVIFYSRMKFKDDSIFVCVQIIVSHSYVTVSPFVFICTEKHIIKFFWSLCG 304
Cdd:cd13949  241 YILDSIVFYSRTKFKNDSILYCVQIIVSHSYATVSPFVFLMTEKHIIKFLRSMCG 295
V1R pfam03402
Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known ...
11-301 4.07e-144

Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known vomeronasal organ receptor families, the V1R family.


Pssm-ID: 460912  Cd Length: 292  Bit Score: 407.49  E-value: 4.07e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998   11 TNMKVILSSEVSVGISANSILFISHLCMFLGESRPKPIDIYIAFFSLTHLMRLVTMGLIAVDMFMPGGRWDSTTCTFLMY 90
Cdd:pfam03402   1 VNIGIIFFSEVGVGISANSILLLFHIFMFFTGHRLRPTDLIIGHLSLIHLLMLLTMGIIAMDAFGSQGRWDDTTCKFLIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998   91 LHIVLRGPTLCATCLLNVLWTITLSPRNSCLTKFKHKSPHHISGAFLFLCVLYMSLSSELL-TITASLNLTSENFLYVSQ 169
Cdd:pfam03402  81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMSISSHLLlSIIATPNLTSSSFIYVTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332803998  170 SCSILPMSYSIKSMFSTKMAIREAFLIGLMVLSSGYMVALLWSHKKQAQHLHSTSLSSKASPEQRATRTIMLLMSFFVVF 249
Cdd:pfam03402 161 SCSILPMSYSMQSLFSTLLASRDVFLIGLMVLSSGYMVALLCRHKKQAQHLHGTSLSPKASPEQRATRTILLLMSFFVVM 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 332803998  250 YILDSVIFYSRMKFKDDSIFVCVQIIVSHSYVTVSPFVFICTEKHIIKFFWS 301
Cdd:pfam03402 241 YILDSIVSYSRTMFKNDSIFYCVQILVSHSYATVSPFVLISTEKRIIKFLRS 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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