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Conserved domains on  [gi|597799967|gb|AHN48128|]
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Hypothetical protein BSS2_II0365 [Brucella suis bv. 1 str. S2]

Protein Classification

cupredoxin domain-containing protein( domain architecture ID 10604510)

uncharacterized cupredoxin-like domain-containing protein, similar to CupA, a cell membrane-anchored Cu(I) chaperone involved in copper resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupredoxin_1 pfam13473
Cupredoxin-like domain; The cupredoxin-like fold consists of a beta-sandwich with 7 strands in ...
 32-122 3.58e-37

Cupredoxin-like domain; The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.


:

Pssm-ID: 379208 [Multi-domain]  Cd Length: 104  Bit Score: 122.31  E-value: 3.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597799967   32 VVLLAVASSVAWAEEPTFRLEFKDGVITPDRLEVPANTRFRIELVNTGSMPAEFESLELRKEKVIAAQSETVMVIRTLDP 111
Cdd:pfam13473   6 AVLFWLSKPAAAADDPTVEITVKDGGFSPSRITVPAGTPVKLEFKNKDKTPAEFESPDLGIEKVLAPGKTSTITIPPLKP 85

                          90
                  ....*....|.
gi 597799967  112 GEYPFFDDFHP 122
Cdd:pfam13473  86 GEYDFFCDMHM 96
 
Name Accession Description Interval E-value
Cupredoxin_1 pfam13473
Cupredoxin-like domain; The cupredoxin-like fold consists of a beta-sandwich with 7 strands in ...
 32-122 3.58e-37

Cupredoxin-like domain; The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.


Pssm-ID: 379208 [Multi-domain]  Cd Length: 104  Bit Score: 122.31  E-value: 3.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597799967   32 VVLLAVASSVAWAEEPTFRLEFKDGVITPDRLEVPANTRFRIELVNTGSMPAEFESLELRKEKVIAAQSETVMVIRTLDP 111
Cdd:pfam13473   6 AVLFWLSKPAAAADDPTVEITVKDGGFSPSRITVPAGTPVKLEFKNKDKTPAEFESPDLGIEKVLAPGKTSTITIPPLKP 85

                          90
                  ....*....|.
gi 597799967  112 GEYPFFDDFHP 122
Cdd:pfam13473  86 GEYDFFCDMHM 96
Cupredoxin_like_3 cd04203
Uncharacterized subfamiy of Cupredoxin; Cupredoxins contain type I copper centers and are ...
 50-130 2.27e-09

Uncharacterized subfamiy of Cupredoxin; Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. Majority of family members contain multiple cupredoxin domain repeats: ceruloplamin and coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, and spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase and the periplasmic domain of cytochrome c oxidase subunit II. Proteins of this uncharacterized subfamily contain a single cupredoxin domain.


Pssm-ID: 259866 [Multi-domain]  Cd Length: 84  Bit Score: 50.69  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597799967  50 RLEFKDGVITPDRLEVPANTRFRIELVNTGSMPAEFESLELRKEKVIAAQSETVMVIRTLDPGEYPFFDDFHPGGTPAIL 129
Cdd:cd04203    3 KITLNDDYFNPNVITVPINEKTTLILHNKGQKSEETETIKKLGIDVVVESEEINITVKPLSPGTYELICRYHLLG*EGKV 82


                 .
gi 597799967 130 I 130
Cdd:cd04203   83 I 83
 
Name Accession Description Interval E-value
Cupredoxin_1 pfam13473
Cupredoxin-like domain; The cupredoxin-like fold consists of a beta-sandwich with 7 strands in ...
 32-122 3.58e-37

Cupredoxin-like domain; The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.


Pssm-ID: 379208 [Multi-domain]  Cd Length: 104  Bit Score: 122.31  E-value: 3.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597799967   32 VVLLAVASSVAWAEEPTFRLEFKDGVITPDRLEVPANTRFRIELVNTGSMPAEFESLELRKEKVIAAQSETVMVIRTLDP 111
Cdd:pfam13473   6 AVLFWLSKPAAAADDPTVEITVKDGGFSPSRITVPAGTPVKLEFKNKDKTPAEFESPDLGIEKVLAPGKTSTITIPPLKP 85

                          90
                  ....*....|.
gi 597799967  112 GEYPFFDDFHP 122
Cdd:pfam13473  86 GEYDFFCDMHM 96
Cupredoxin_like_3 cd04203
Uncharacterized subfamiy of Cupredoxin; Cupredoxins contain type I copper centers and are ...
 50-130 2.27e-09

Uncharacterized subfamiy of Cupredoxin; Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. Majority of family members contain multiple cupredoxin domain repeats: ceruloplamin and coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, and spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase and the periplasmic domain of cytochrome c oxidase subunit II. Proteins of this uncharacterized subfamily contain a single cupredoxin domain.


Pssm-ID: 259866 [Multi-domain]  Cd Length: 84  Bit Score: 50.69  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597799967  50 RLEFKDGVITPDRLEVPANTRFRIELVNTGSMPAEFESLELRKEKVIAAQSETVMVIRTLDPGEYPFFDDFHPGGTPAIL 129
Cdd:cd04203    3 KITLNDDYFNPNVITVPINEKTTLILHNKGQKSEETETIKKLGIDVVVESEEINITVKPLSPGTYELICRYHLLG*EGKV 82


                 .
gi 597799967 130 I 130
Cdd:cd04203   83 I 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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