|
Name |
Accession |
Description |
Interval |
E-value |
| mycolic_MTase |
NF040660 |
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include ... |
24-306 |
0e+00 |
|
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include tailoring enzymes that make site-specific modifications to mycolic acid precursor molecules. These include Mycobacterium tuberculosis enzymes MmaA1-MmaA4, CmaA1-CmaA2, and PcaA. The family also includes UmaA, reported to be the lone member of this family not involved in mycolic acid biosynthesis. No members of this family are found in species that lack mycolic acids. This model excludes two more distantly related paralogs, Rv0447c (UfaA1 ) and Rv3720, that are also encoded in the Mycobacterium tuberculosis H37Rv genome.
Pssm-ID: 468626 Cd Length: 283 Bit Score: 575.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 24 LTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIA 103
Cdd:NF040660 1 LRPHFEDVQAHYDLSDDFFALFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAVE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 104 QYDVNVVGLTLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVL 183
Cdd:NF040660 81 KYDVNVVGLTLSKNQAAHVQQVLDEIDTPRSRRVLLQGWEEFDEPVDRIVSIGAFEHFGHERYDDFFKRAYNILPADGRM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 184 LLHTITGLTRQQMVDHGLPLTLWLARFLKFIATEIFPGGQPPTIEMVEDQSAKTGFTLTRRQSLQPHYARTLDLWAEALQ 263
Cdd:NF040660 161 LLHTITGLHRKEMHERGLPLTMELARFIKFIVTEIFPGGRLPSIEMVVEHAEKAGFTVTRVQSLQPHYARTLDLWADALQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 984973198 264 EHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQFTLAK 306
Cdd:NF040660 241 AHKDEAIAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLAK 283
|
|
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
23-302 |
4.35e-174 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 482.21 E-value: 4.35e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 23 DLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAI 102
Cdd:pfam02353 1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 103 AQYDVNVVGLTLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGV 182
Cdd:pfam02353 81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 183 LLLHTITGLTRQQMVDHGLPltlwlarfLKFIATEIFPGGQPPTIEMVEDQSAKTGFTLTRRQSLQPHYARTLDLWAEAL 262
Cdd:pfam02353 161 MLLHTITGLHPDETSERGLP--------LKFIDKYIFPGGELPSISMIVESSSEAGFTVEDVESLRPHYAKTLDLWAENL 232
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 984973198 263 QEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQF 302
Cdd:pfam02353 233 QANKDEAIALQSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
33-187 |
1.14e-66 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 205.55 E-value: 1.14e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 33 AHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGL 112
Cdd:COG2230 1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 984973198 113 TLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQF--NEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLLHT 187
Cdd:COG2230 81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
32-306 |
3.42e-61 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 198.92 E-value: 3.42e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 32 QAHYDLSDDFFRLFLDPTQTYSCAHFEREDmTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVG 111
Cdd:PRK11705 117 KEHYDLGNDLFEAMLDPRMQYSCGYWKDAD-TLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVG 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 112 LTLSKNQAAHVQKSFDEMDTprdrRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLLHTITGL 191
Cdd:PRK11705 196 VTISAEQQKLAQERCAGLPV----EIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTIGSN 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 192 TRQQMVDhglPltlWLARFlkfiateIFPGGQPPTIEMVEDQSAKTgFTLTRRQSLQPHYARTLDLWAEALQEHKSEAIA 271
Cdd:PRK11705 272 KTDTNVD---P---WINKY-------IFPNGCLPSVRQIAQASEGL-FVMEDWHNFGADYDRTLMAWHENFEAAWPELAD 337
|
250 260 270
....*....|....*....|....*....|....*..
gi 984973198 272 IQSEEVYE--RYmkYLTGCAKLFRVGYIDVNQFTLAK 306
Cdd:PRK11705 338 NYSERFYRmwRY--YLLSCAGAFRARDIQLWQVVFSP 372
|
|
| cyclopro_CfaB |
NF040703 |
C17 cyclopropane fatty acid synthase CfaB; |
29-301 |
9.44e-58 |
|
C17 cyclopropane fatty acid synthase CfaB;
Pssm-ID: 468667 [Multi-domain] Cd Length: 393 Bit Score: 190.59 E-value: 9.44e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 29 EDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVN 108
Cdd:NF040703 105 AAISYHYDLSNDFYALWLDPDMVYSCAYFETGTEDLAQAQQAKLRHLCRKLRLQPGERLLDVGCGWGGLARFAAREFGVE 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 109 VVGLTLSKNQ-------------AAHVQKSF-DEMDTPRDrrvllagwEQFnepvDRIVSIGAFEHFGHDRHADFFARAH 174
Cdd:NF040703 185 VFGITLSKEQlklarervaaeglQDRVQLELlDYRDLPQD--------GRF----DKVVSVGMFEHVGHANLPLYCQRLF 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 175 KILPPDGVLLLHTITGL-TRQQMVDHGLPltlwlarflKFIATEIFPGGQPPTIEMVEDQSAKTGFTLTRRQSLQPHYAR 253
Cdd:NF040703 253 GAVRPGGLVMNHGITARhTDGRPVGRGAG---------EFIGRYVFPHGELPHLATITASISEAGLEVVDVESLRLHYAR 323
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 984973198 254 TLDLWAEALQEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQ 301
Cdd:NF040703 324 TLEHWSARLEARLDEAARLVPERALRIWRLYLAGCAYGFARGWINLHQ 371
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
86-190 |
1.36e-12 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 63.22 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 86 TLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAHVQKsFDEMDTPRDRRVLLAGWEQF----NEPVDRIVSIGAFEHF 161
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARK-AAAALLADNVEVLKGDAEELppeaDESFDVIISDPPLHHL 79
|
90 100
....*....|....*....|....*....
gi 984973198 162 gHDRHADFFARAHKILPPDGVLLLHTITG 190
Cdd:cd02440 80 -VEDLARFLEEARRLLKPGGVLVLTLVLA 107
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| mycolic_MTase |
NF040660 |
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include ... |
24-306 |
0e+00 |
|
cyclopropane mycolic acid synthase family methyltransferase; Members of this family include tailoring enzymes that make site-specific modifications to mycolic acid precursor molecules. These include Mycobacterium tuberculosis enzymes MmaA1-MmaA4, CmaA1-CmaA2, and PcaA. The family also includes UmaA, reported to be the lone member of this family not involved in mycolic acid biosynthesis. No members of this family are found in species that lack mycolic acids. This model excludes two more distantly related paralogs, Rv0447c (UfaA1 ) and Rv3720, that are also encoded in the Mycobacterium tuberculosis H37Rv genome.
Pssm-ID: 468626 Cd Length: 283 Bit Score: 575.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 24 LTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIA 103
Cdd:NF040660 1 LRPHFEDVQAHYDLSDDFFALFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAVE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 104 QYDVNVVGLTLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVL 183
Cdd:NF040660 81 KYDVNVVGLTLSKNQAAHVQQVLDEIDTPRSRRVLLQGWEEFDEPVDRIVSIGAFEHFGHERYDDFFKRAYNILPADGRM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 184 LLHTITGLTRQQMVDHGLPLTLWLARFLKFIATEIFPGGQPPTIEMVEDQSAKTGFTLTRRQSLQPHYARTLDLWAEALQ 263
Cdd:NF040660 161 LLHTITGLHRKEMHERGLPLTMELARFIKFIVTEIFPGGRLPSIEMVVEHAEKAGFTVTRVQSLQPHYARTLDLWADALQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 984973198 264 EHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQFTLAK 306
Cdd:NF040660 241 AHKDEAIAIQSEEVYERYMKYLTGCAKLFRDGYIDVNQFTLAK 283
|
|
| CMAS |
pfam02353 |
Mycolic acid cyclopropane synthetase; This family consist of ... |
23-302 |
4.35e-174 |
|
Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.
Pssm-ID: 396777 [Multi-domain] Cd Length: 272 Bit Score: 482.21 E-value: 4.35e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 23 DLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAI 102
Cdd:pfam02353 1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 103 AQYDVNVVGLTLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGV 182
Cdd:pfam02353 81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 183 LLLHTITGLTRQQMVDHGLPltlwlarfLKFIATEIFPGGQPPTIEMVEDQSAKTGFTLTRRQSLQPHYARTLDLWAEAL 262
Cdd:pfam02353 161 MLLHTITGLHPDETSERGLP--------LKFIDKYIFPGGELPSISMIVESSSEAGFTVEDVESLRPHYAKTLDLWAENL 232
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 984973198 263 QEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQF 302
Cdd:pfam02353 233 QANKDEAIALQSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
33-187 |
1.14e-66 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 205.55 E-value: 1.14e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 33 AHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGL 112
Cdd:COG2230 1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 984973198 113 TLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQF--NEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLLHT 187
Cdd:COG2230 81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
|
|
| PRK11705 |
PRK11705 |
cyclopropane fatty acyl phospholipid synthase; |
32-306 |
3.42e-61 |
|
cyclopropane fatty acyl phospholipid synthase;
Pssm-ID: 183282 Cd Length: 383 Bit Score: 198.92 E-value: 3.42e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 32 QAHYDLSDDFFRLFLDPTQTYSCAHFEREDmTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVG 111
Cdd:PRK11705 117 KEHYDLGNDLFEAMLDPRMQYSCGYWKDAD-TLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVG 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 112 LTLSKNQAAHVQKSFDEMDTprdrRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLLHTITGL 191
Cdd:PRK11705 196 VTISAEQQKLAQERCAGLPV----EIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTIGSN 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 192 TRQQMVDhglPltlWLARFlkfiateIFPGGQPPTIEMVEDQSAKTgFTLTRRQSLQPHYARTLDLWAEALQEHKSEAIA 271
Cdd:PRK11705 272 KTDTNVD---P---WINKY-------IFPNGCLPSVRQIAQASEGL-FVMEDWHNFGADYDRTLMAWHENFEAAWPELAD 337
|
250 260 270
....*....|....*....|....*....|....*..
gi 984973198 272 IQSEEVYE--RYmkYLTGCAKLFRVGYIDVNQFTLAK 306
Cdd:PRK11705 338 NYSERFYRmwRY--YLLSCAGAFRARDIQLWQVVFSP 372
|
|
| cyclopro_CfaB |
NF040703 |
C17 cyclopropane fatty acid synthase CfaB; |
29-301 |
9.44e-58 |
|
C17 cyclopropane fatty acid synthase CfaB;
Pssm-ID: 468667 [Multi-domain] Cd Length: 393 Bit Score: 190.59 E-value: 9.44e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 29 EDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVN 108
Cdd:NF040703 105 AAISYHYDLSNDFYALWLDPDMVYSCAYFETGTEDLAQAQQAKLRHLCRKLRLQPGERLLDVGCGWGGLARFAAREFGVE 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 109 VVGLTLSKNQ-------------AAHVQKSF-DEMDTPRDrrvllagwEQFnepvDRIVSIGAFEHFGHDRHADFFARAH 174
Cdd:NF040703 185 VFGITLSKEQlklarervaaeglQDRVQLELlDYRDLPQD--------GRF----DKVVSVGMFEHVGHANLPLYCQRLF 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 175 KILPPDGVLLLHTITGL-TRQQMVDHGLPltlwlarflKFIATEIFPGGQPPTIEMVEDQSAKTGFTLTRRQSLQPHYAR 253
Cdd:NF040703 253 GAVRPGGLVMNHGITARhTDGRPVGRGAG---------EFIGRYVFPHGELPHLATITASISEAGLEVVDVESLRLHYAR 323
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 984973198 254 TLDLWAEALQEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVGYIDVNQ 301
Cdd:NF040703 324 TLEHWSARLEARLDEAARLVPERALRIWRLYLAGCAYGFARGWINLHQ 371
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
73-212 |
4.79e-13 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 65.40 E-value: 4.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 73 DLALGKLGLQPGMTLLDIGCGWGATMrRAIAQYDVNVVGLTLSKNQAAHVQKSFDEMDtpRDRRVLLAGWEQF---NEPV 149
Cdd:COG2226 12 EALLAALGLRPGARVLDLGCGTGRLA-LALAERGARVTGVDISPEMLELARERAAEAG--LNVEFVVGDAEDLpfpDGSF 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 984973198 150 DRIVSIGAFEHFGHDRHAdfFARAHKILPPDGVLLLhtitgltrqqmVDHGLPLTLWLARFLK 212
Cdd:COG2226 89 DLVISSFVLHHLPDPERA--LAEIARVLKPGGRLVV-----------VDFSPPDLAELEELLA 138
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
86-190 |
1.36e-12 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 63.22 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 86 TLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAHVQKsFDEMDTPRDRRVLLAGWEQF----NEPVDRIVSIGAFEHF 161
Cdd:cd02440 1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARK-AAAALLADNVEVLKGDAEELppeaDESFDVIISDPPLHHL 79
|
90 100
....*....|....*....|....*....
gi 984973198 162 gHDRHADFFARAHKILPPDGVLLLHTITG 190
Cdd:cd02440 80 -VEDLARFLEEARRLLKPGGVLVLTLVLA 107
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
88-181 |
2.84e-12 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 61.81 E-value: 2.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 88 LDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAHVQKSFDEMDtPRDRRVL--LAGWEQFNEPVDRIVSIGAFEHFGHDR 165
Cdd:pfam13649 2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAG-LNVEFVQgdAEDLPFPDGSFDLVVSSGVLHHLPDPD 80
|
90
....*....|....*.
gi 984973198 166 HADFFARAHKILPPDG 181
Cdd:pfam13649 81 LEAALREIARVLKPGG 96
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
81-188 |
7.48e-11 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 58.88 E-value: 7.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 81 LQPGMTLLDIGCGWGATMrRAIAQYDVNVVGLTLSKNQAAHVQKSFDEMDTprdrRVLLAGWEQF---NEPVDRIVSIGA 157
Cdd:COG2227 22 LPAGGRVLDVGCGTGRLA-LALARRGADVTGVDISPEALEIARERAAELNV----DFVQGDLEDLpleDGSFDLVICSEV 96
|
90 100 110
....*....|....*....|....*....|.
gi 984973198 158 FEHFGHDrhADFFARAHKILPPDGVLLLHTI 188
Cdd:COG2227 97 LEHLPDP--AALLRELARLLKPGGLLLLSTP 125
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
83-185 |
8.43e-10 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 54.83 E-value: 8.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 83 PGMTLLDIGCGWGATMRRAIAQY-DVNVVGLTLSKNQAAHVQKSFDEMdtprdrRVLLAGWEQF--NEPVDRIVSIGAFE 159
Cdd:COG4106 1 PPRRVLDLGCGTGRLTALLAERFpGARVTGVDLSPEMLARARARLPNV------RFVVADLRDLdpPEPFDLVVSNAALH 74
|
90 100
....*....|....*....|....*.
gi 984973198 160 HFghDRHADFFARAHKILPPDGVLLL 185
Cdd:COG4106 75 WL--PDHAALLARLAAALAPGGVLAV 98
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
71-209 |
2.85e-08 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 52.69 E-value: 2.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 71 KIDLALGKLGLQPGMTLLDIGCGWGaTMRRAIAQYDVNVVGLTLSKNQAAH-----VQKSFDEMDtprdrrvlLAGWEQF 145
Cdd:COG4976 34 LAEELLARLPPGPFGRVLDLGCGTG-LLGEALRPRGYRLTGVDLSEEMLAKarekgVYDRLLVAD--------LADLAEP 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 984973198 146 NEPVDRIVSIGAFEHFGhdRHADFFARAHKILPPDGVLLL------------HTITGLtRQQMVDHGLPL--TLWLAR 209
Cdd:COG4976 105 DGRFDLIVAADVLTYLG--DLAAVFAGVARALKPGGLFIFsvedadgsgryaHSLDYV-RDLLAAAGFEVpgLLVVAR 179
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
65-218 |
4.39e-08 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 52.61 E-value: 4.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 65 EEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLTLSK----------NQAAHVQKSFDEMDtprd 134
Cdd:COG0500 8 DELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPeaialararaAKAGLGNVEFLVAD---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 135 rrvlLAGWEQFN-EPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLL----------HTITGLTRQQMVDHGLPL 203
Cdd:COG0500 84 ----LAELDPLPaESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLsasdaaaalsLARLLLLATASLLELLLL 159
|
170
....*....|....*
gi 984973198 204 TLWLARFLKFIATEI 218
Cdd:COG0500 160 LRLLALELYLRALLA 174
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
88-185 |
5.85e-08 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 49.59 E-value: 5.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 88 LDIGCGWGAtMRRAIAQYDVNVVGLTLSKNQAAHVQKSFdemdTPRDRRVLLAGWEQF---NEPVDRIVSIGAFEHFghD 164
Cdd:pfam08241 1 LDVGCGTGL-LTELLARLGARVTGVDISPEMLELAREKA----PREGLTFVVGDAEDLpfpDNSFDLVLSSEVLHHV--E 73
|
90 100
....*....|....*....|.
gi 984973198 165 RHADFFARAHKILPPDGVLLL 185
Cdd:pfam08241 74 DPERALREIARVLKPGGILII 94
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
88-183 |
4.73e-07 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 47.36 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 88 LDIGCGWGATMRRAIAQY-DVNVVGLTLSKNQAAHVQKSFDE---MDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGH 163
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERLAAlglLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80
|
90 100
....*....|....*....|
gi 984973198 164 DRhaDFFARAHKILPPDGVL 183
Cdd:pfam08242 81 PR--AVLRNIRRLLKPGGVL 98
|
|
| Methyltransf_23 |
pfam13489 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
83-189 |
4.33e-05 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 404385 [Multi-domain] Cd Length: 162 Bit Score: 43.19 E-value: 4.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 83 PGMTLLDIGCGWGaTMRRAIAQYDVNVVGLTLS-----KNQAAHVQKSFDEMDtprdrrvllagWEQFNEPVDRIVSIGA 157
Cdd:pfam13489 22 SPGRVLDFGCGTG-IFLRLLRAQGFSVTGVDPSpiaieRALLNVRFDQFDEQE-----------AAVPAGKFDVIVAREV 89
|
90 100 110
....*....|....*....|....*....|..
gi 984973198 158 FEHFGHdrHADFFARAHKILPPDGVLLLHTIT 189
Cdd:pfam13489 90 LEHVPD--PPALLRQIAALLKPGGLLLLSTPL 119
|
|
| PLN02336 |
PLN02336 |
phosphoethanolamine N-methyltransferase |
39-117 |
9.87e-05 |
|
phosphoethanolamine N-methyltransferase
Pssm-ID: 177970 [Multi-domain] Cd Length: 475 Bit Score: 43.59 E-value: 9.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 39 DDFFRLFLDPTQtYSCAHFEREDMTLEEAQIAKIDLA-----LGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLT 113
Cdd:PLN02336 218 DKGFQRFLDNVQ-YKSSGILRYERVFGEGFVSTGGLEttkefVDKLDLKPGQKVLDVGCGIGGGDFYMAENFDVHVVGID 296
|
....
gi 984973198 114 LSKN 117
Cdd:PLN02336 297 LSVN 300
|
|
| CobL |
COG2242 |
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ... |
57-96 |
3.10e-03 |
|
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 441843 [Multi-domain] Cd Length: 403 Bit Score: 38.99 E-value: 3.10e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 984973198 57 FERED--MTLEEAQIakidLALGKLGLQPGMTLLDIGCGWGA 96
Cdd:COG2242 223 FERDKgpITKREVRA----LTLAKLALRPGDVLWDIGAGSGS 260
|
|
| PLN02244 |
PLN02244 |
tocopherol O-methyltransferase |
66-120 |
3.74e-03 |
|
tocopherol O-methyltransferase
Pssm-ID: 215135 [Multi-domain] Cd Length: 340 Bit Score: 38.57 E-value: 3.74e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 66 EAQIAKIDLALGKLGLQPGM-----TLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAA 120
Cdd:PLN02244 96 QAQIRMIEESLAWAGVPDDDekrpkRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAA 155
|
|
| cbiT |
PRK00377 |
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional |
57-96 |
4.52e-03 |
|
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
Pssm-ID: 234740 Cd Length: 198 Bit Score: 37.47 E-value: 4.52e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 984973198 57 FERED---MTLEEAQIakidLALGKLGLQPGMTLLDIGCGWGA 96
Cdd:PRK00377 15 FERDEeipMTKEEIRA----LALSKLRLRKGDMILDIGCGTGS 53
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
71-185 |
6.47e-03 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 37.09 E-value: 6.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 984973198 71 KIDLA----LGKLGLQPGMTLLDIGCGWG-----ATMRRAIAQ---YDVNVVGLTLSK-----NQ--AAHVQKSfDEMDT 131
Cdd:COG2813 33 RLDIGtrllLEHLPEPLGGRVLDLGCGYGviglaLAKRNPEARvtlVDVNARAVELARanaaaNGleNVEVLWS-DGLSG 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 984973198 132 PRDRRvllagweqfnepVDRIVS---IgafeHFGHDRHAD----FFARAHKILPPDGVLLL 185
Cdd:COG2813 112 VPDGS------------FDLILSnppF----HAGRAVDKEvahaLIADAARHLRPGGELWL 156
|
|
| |
