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Conserved domains on  [gi|10435738|dbj|BAB14656|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-96 6.70e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 6.70e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10435738     35 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLaGIAVSKPDLITCLEQGKEPWN 96
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-272 1.55e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.55e-06
                          10        20
                  ....*....|....*....|....*
gi 10435738   248 LTRHRRIHTGEKPYKCEQCGKAFKQ 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-303 7.61e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 7.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 202 KKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQC--EECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSStlTTH 279
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA--SSS 108

                        90       100
                ....*....|....*....|....
gi 10435738 280 KIIHTGEKPYRCENVAKPLTGPHT 303
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSS 132
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-280 4.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 4.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 106 PPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCRSVDECNLHKecyDELNQCLTTTQSEIFQYDKYVNV 185
Cdd:COG5189 259 GPSNEEMLYKYISPSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGISTGEMID---VRKLPCTNSSSNGKLAHGGERNI 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 186 FYKFSNpniQKIRhtGKKPFKCK--KCDKSFCMLLHLTQHkRIHIRENSYQCEECGKVfnwfstltRHRRIHTGEKPYKC 263
Cdd:COG5189 336 DTPSRM---LKVK--DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRC 401

                       170
                ....*....|....*..
gi 10435738 264 EQCGKAFKQSSTLTTHK 280
Cdd:COG5189 402 EVCDKRYKNLNGLKYHR 418
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-96 6.70e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 6.70e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10435738     35 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLaGIAVSKPDLITCLEQGKEPWN 96
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 10435738    34 PLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 1.41e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 1.41e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 10435738  35 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFL 74
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-272 1.55e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.55e-06
                          10        20
                  ....*....|....*....|....*
gi 10435738   248 LTRHRRIHTGEKPYKCEQCGKAFKQ 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-303 7.61e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 7.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 202 KKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQC--EECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSStlTTH 279
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA--SSS 108

                        90       100
                ....*....|....*....|....
gi 10435738 280 KIIHTGEKPYRCENVAKPLTGPHT 303
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSS 132
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-280 4.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 4.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 106 PPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCRSVDECNLHKecyDELNQCLTTTQSEIFQYDKYVNV 185
Cdd:COG5189 259 GPSNEEMLYKYISPSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGISTGEMID---VRKLPCTNSSSNGKLAHGGERNI 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 186 FYKFSNpniQKIRhtGKKPFKCK--KCDKSFCMLLHLTQHkRIHIRENSYQCEECGKVfnwfstltRHRRIHTGEKPYKC 263
Cdd:COG5189 336 DTPSRM---LKVK--DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRC 401

                       170
                ....*....|....*..
gi 10435738 264 EQCGKAFKQSSTLTTHK 280
Cdd:COG5189 402 EVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-243 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|....*
gi 10435738   219 HLTQHKRIHIRENSYQCEECGKVFN 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-96 6.70e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 6.70e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10435738     35 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFLaGIAVSKPDLITCLEQGKEPWN 96
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 1.05e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 1.05e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 10435738    34 PLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 1.41e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 1.41e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 10435738  35 LTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYRNLVFL 74
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-272 1.55e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.55e-06
                          10        20
                  ....*....|....*....|....*
gi 10435738   248 LTRHRRIHTGEKPYKCEQCGKAFKQ 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-303 7.61e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 7.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 202 KKPFKCKKCDKSFCMLLHLTQHKRIHIRENSYQC--EECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSStlTTH 279
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA--SSS 108

                        90       100
                ....*....|....*....|....
gi 10435738 280 KIIHTGEKPYRCENVAKPLTGPHT 303
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSS 132
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-280 4.34e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 4.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 106 PPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCRSVDECNLHKecyDELNQCLTTTQSEIFQYDKYVNV 185
Cdd:COG5189 259 GPSNEEMLYKYISPSQGSAELFEESSLGFDYEFIHKSVGNKEIRGGISTGEMID---VRKLPCTNSSSNGKLAHGGERNI 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 186 FYKFSNpniQKIRhtGKKPFKCK--KCDKSFCMLLHLTQHkRIHIRENSYQCEECGKVfnwfstltRHRRIHTGEKPYKC 263
Cdd:COG5189 336 DTPSRM---LKVK--DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRC 401

                       170
                ....*....|....*..
gi 10435738 264 EQCGKAFKQSSTLTTHK 280
Cdd:COG5189 402 EVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-275 4.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435738 184 NVFYKFSNPNIQKIrhtgkKPFKCKKCDKSFCMLLHLTQHKR--IHIRENSYQCEE----CGKVFNWFSTLTRHRRIHTG 257
Cdd:COG5048 274 SPNESDSSSEKGFS-----LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTS 348

                        90       100
                ....*....|....*....|
gi 10435738 258 EKPYKC--EQCGKAFKQSST 275
Cdd:COG5048 349 ISPAKEklLNSSSKFSPLLN 368
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 261-283 2.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.44e-03
                          10        20
                  ....*....|....*....|...
gi 10435738   261 YKCEQCGKAFKQSSTLTTHKIIH 283
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-243 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|....*
gi 10435738   219 HLTQHKRIHIRENSYQCEECGKVFN 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-291 4.80e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 4.80e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10435738 231 NSYQCEECGKVFNWFSTLTRHRR--IHTGE--KPYKC--EQCGKAFKQSSTLTTHKIIHTGEKPYRC 291
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
196-214 9.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.32e-03
                          10
                  ....*....|....*....
gi 10435738   196 KIRHTGKKPFKCKKCDKSF 214
Cdd:pfam13465   6 MRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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