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Conserved domains on  [gi|12841774|dbj|BAB25346|]
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unnamed protein product [Mus musculus]

Protein Classification

canopy family protein( domain architecture ID 10571424)

canopy family protein is a DUF3456 domain-containing protein; similar to Drosophila melanogaster protein seele and vertebrate protein canopy that is also known as PRAT4 (A and B), a Protein Associated with Toll-like receptor 4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3456 pfam11938
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ...
 27-171 1.78e-56

TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.


:

Pssm-ID: 463404  Cd Length: 151  Bit Score: 174.82  E-value: 1.78e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12841774    27 HCGACRALVDELEWEIARVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEVCDRMKEYGEQIDPSTHRKNYV 106
Cdd:pfam11938   1 KCEVCKALADELEYALSKTDPSKEVDVGGFRLDPDGKRKKKKIPYARSELRLTELLEGVCERMLDYNLHKERSTSTRTFV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12841774   107 RVVSRNGE---SSELDLQGIRIDS-DISGTLKFACESIVEEYEDELIEFFS--READNVKDKLCSKRTDLC 171
Cdd:pfam11938  81 TLHGLNKGvkvDLGIPYELWDEPSaEVNKSLKFQCETIVEEYEDEIEEWYFnhQDEKDLEKYLCSEDSDLC 151
 
Name Accession Description Interval E-value
DUF3456 pfam11938
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ...
 27-171 1.78e-56

TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.


Pssm-ID: 463404  Cd Length: 151  Bit Score: 174.82  E-value: 1.78e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12841774    27 HCGACRALVDELEWEIARVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEVCDRMKEYGEQIDPSTHRKNYV 106
Cdd:pfam11938   1 KCEVCKALADELEYALSKTDPSKEVDVGGFRLDPDGKRKKKKIPYARSELRLTELLEGVCERMLDYNLHKERSTSTRTFV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12841774   107 RVVSRNGE---SSELDLQGIRIDS-DISGTLKFACESIVEEYEDELIEFFS--READNVKDKLCSKRTDLC 171
Cdd:pfam11938  81 TLHGLNKGvkvDLGIPYELWDEPSaEVNKSLKFQCETIVEEYEDEIEEWYFnhQDEKDLEKYLCSEDSDLC 151
 
Name Accession Description Interval E-value
DUF3456 pfam11938
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ...
 27-171 1.78e-56

TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.


Pssm-ID: 463404  Cd Length: 151  Bit Score: 174.82  E-value: 1.78e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12841774    27 HCGACRALVDELEWEIARVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEVCDRMKEYGEQIDPSTHRKNYV 106
Cdd:pfam11938   1 KCEVCKALADELEYALSKTDPSKEVDVGGFRLDPDGKRKKKKIPYARSELRLTELLEGVCERMLDYNLHKERSTSTRTFV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12841774   107 RVVSRNGE---SSELDLQGIRIDS-DISGTLKFACESIVEEYEDELIEFFS--READNVKDKLCSKRTDLC 171
Cdd:pfam11938  81 TLHGLNKGvkvDLGIPYELWDEPSaEVNKSLKFQCETIVEEYEDEIEEWYFnhQDEKDLEKYLCSEDSDLC 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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