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Conserved domains on  [gi|12860823|dbj|BAB32054|]
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unnamed protein product [Mus musculus]

Protein Classification

RhoGEF domain-containing protein( domain architecture ID 4023)

RhoGEF domain-containing protein contains guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family

CATH:  1.20.900.10
Gene Ontology:  GO:0005085
PubMed:  16393146|11911885|15817389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGEF super family cl02571
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
 98-170 2.38e-08

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


The actual alignment was detected with superfamily member smart00325:

Pssm-ID: 470622 [Multi-domain]  Cd Length: 180  Bit Score: 51.15  E-value: 2.38e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12860823     98 IIRELIQTERDYLTDLELCLREVVQPLRSKQ--IDRLDVEGLFSNIEFVRQISAKLLSLLEEATTYVEPAMQVIG 170
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVFLKPLKKELklLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDDSVERIG 75
 
Name Accession Description Interval E-value
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
 98-170 2.38e-08

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 51.15  E-value: 2.38e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12860823     98 IIRELIQTERDYLTDLELCLREVVQPLRSKQ--IDRLDVEGLFSNIEFVRQISAKLLSLLEEATTYVEPAMQVIG 170
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVFLKPLKKELklLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDDSVERIG 75
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
 98-152 4.77e-08

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 49.99  E-value: 4.77e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12860823    98 IIRELIQTERDYLTDLELcLREVVQPLRSKQIDRL--DVEGLFSNIEFVRQISAKLL 152
Cdd:pfam00621   1 VIKELLQTERSYVRDLEI-LVEVFLPPNSKPLSESeeEIKTIFSNIEEIYELHRQLL 56
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
 95-158 2.50e-07

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 48.06  E-value: 2.50e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12860823  95 RAKIIRELIQTERDYLTDLELCLREVVQPLRS--KQIDRLDVEGLFSNIEFVRQISAKLLSLLEEA 158
Cdd:cd00160   1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKelLPLSPEEVELLFGNIEEIYEFHRIFLKSLEER 66
 
Name Accession Description Interval E-value
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
 98-170 2.38e-08

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 51.15  E-value: 2.38e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12860823     98 IIRELIQTERDYLTDLELCLREVVQPLRSKQ--IDRLDVEGLFSNIEFVRQISAKLLSLLEEATTYVEPAMQVIG 170
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVFLKPLKKELklLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDDSVERIG 75
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
 98-152 4.77e-08

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 49.99  E-value: 4.77e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 12860823    98 IIRELIQTERDYLTDLELcLREVVQPLRSKQIDRL--DVEGLFSNIEFVRQISAKLL 152
Cdd:pfam00621   1 VIKELLQTERSYVRDLEI-LVEVFLPPNSKPLSESeeEIKTIFSNIEEIYELHRQLL 56
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
 95-158 2.50e-07

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 48.06  E-value: 2.50e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12860823  95 RAKIIRELIQTERDYLTDLELCLREVVQPLRS--KQIDRLDVEGLFSNIEFVRQISAKLLSLLEEA 158
Cdd:cd00160   1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKelLPLSPEEVELLFGNIEEIYEFHRIFLKSLEER 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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