Delta and Notch-like EGF-related receptor C-terminus; This family represents the C-terminal region of the Delta and Notch-like epidermal growth factor-related receptor (DNER) containing the transmembrane domain and the short cytoplasmic region including AP-1-binding site required for its somatodendritic distribution. This receptor is highly expressed in Purkinje cells taking part in the differentiation and maturation of Bergmann glia via physical contact with Purkinje cells and granular cells. Recently, it has been demonstrated that DNER is induced in lung recruited macrophages after chronic inflammation in which induces IFNgamma expression via a non-canonical Notch NFkappaB pathway.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17062030   635 PRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPaYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVT 714
Cdd:pfam19330  11 PRESQRSTFACCSVPFPLLKFALLEANCSLISNKEQKSSRP-YRFTKATQKIDPELSKRIICIQSILFGKKSRPAMYDVT 89

                          90       100
                  ....*....|....*....|...
gi 17062030   715 PIAYEDYSPDDKPLVTLIKTKDL 737
Cdd:pfam19330  90 PIAYEDYSPDDKPLVTLIKTKDL 112

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 17062030 507 NECLSA-PCLNAATCRDLINGYECVCLAEYKGTHCE 541
Cdd:cd00054   3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 17062030 393 IDYCVL-DPCRNGATCVSSLSGFTCQCLEGYFASACE 428
Cdd:cd00054   2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Delta and Notch-like EGF-related receptor C-terminus; This family represents the C-terminal region of the Delta and Notch-like epidermal growth factor-related receptor (DNER) containing the transmembrane domain and the short cytoplasmic region including AP-1-binding site required for its somatodendritic distribution. This receptor is highly expressed in Purkinje cells taking part in the differentiation and maturation of Bergmann glia via physical contact with Purkinje cells and granular cells. Recently, it has been demonstrated that DNER is induced in lung recruited macrophages after chronic inflammation in which induces IFNgamma expression via a non-canonical Notch NFkappaB pathway.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17062030   635 PRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPaYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVT 714
Cdd:pfam19330  11 PRESQRSTFACCSVPFPLLKFALLEANCSLISNKEQKSSRP-YRFTKATQKIDPELSKRIICIQSILFGKKSRPAMYDVT 89

                          90       100
                  ....*....|....*....|...
gi 17062030   715 PIAYEDYSPDDKPLVTLIKTKDL 737
Cdd:pfam19330  90 PIAYEDYSPDDKPLVTLIKTKDL 112

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17062030    581 DINECDS-NPCHHAGTCLDQPNGYTCHCPHGWV-GANCE 617
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 17062030 507 NECLSA-PCLNAATCRDLINGYECVCLAEYKGTHCE 541
Cdd:cd00054   3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 17062030 431 VDPCMS-SPCQNNGTCYVDGVHFTCSCSPGFTGPTC 465
Cdd:cd00054   2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20
                  ....*....|....*....|....*...
gi 17062030   396 CVLDPCRNGATCVSSLSGFTCQCLEGYF 423
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 17062030   434 CMSSPCQNNGTCYVDGVHFTCSCSPGFTGPT 464
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Delta and Notch-like EGF-related receptor C-terminus; This family represents the C-terminal region of the Delta and Notch-like epidermal growth factor-related receptor (DNER) containing the transmembrane domain and the short cytoplasmic region including AP-1-binding site required for its somatodendritic distribution. This receptor is highly expressed in Purkinje cells taking part in the differentiation and maturation of Bergmann glia via physical contact with Purkinje cells and granular cells. Recently, it has been demonstrated that DNER is induced in lung recruited macrophages after chronic inflammation in which induces IFNgamma expression via a non-canonical Notch NFkappaB pathway.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17062030   635 PRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPaYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVT 714
Cdd:pfam19330  11 PRESQRSTFACCSVPFPLLKFALLEANCSLISNKEQKSSRP-YRFTKATQKIDPELSKRIICIQSILFGKKSRPAMYDVT 89

                          90       100
                  ....*....|....*....|...
gi 17062030   715 PIAYEDYSPDDKPLVTLIKTKDL 737
Cdd:pfam19330  90 PIAYEDYSPDDKPLVTLIKTKDL 112

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17062030    581 DINECDS-NPCHHAGTCLDQPNGYTCHCPHGWV-GANCE 617
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 17062030 507 NECLSA-PCLNAATCRDLINGYECVCLAEYKGTHCE 541
Cdd:cd00054   3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 17062030 584 ECD-SNPCHHAGTCLDQPNGYTCHCPHGWVGA-NCE 617
Cdd:cd00053   1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 17062030 393 IDYCVL-DPCRNGATCVSSLSGFTCQCLEGYFASACE 428
Cdd:cd00054   2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|.
gi 17062030    393 IDYCVL-DPCRNGATCVSSLSGFTCQCLEGY 422
Cdd:smart00179   2 IDECASgNPCQNGGTCVNTVGSYRCECPPGY 32