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Conserved domains on  [gi|26334641|dbj|BAC31021|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
668-747 1.70e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 1.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNT-----STTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    743 HGNQS 747
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 57-151 5.53e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 5.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRakPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP--GSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 26334641  137 SAGIGVFSDPFLFQT 151
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 570-654 5.72e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 5.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTV---DNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpgsETSYTLTGLKPGTEYEFRVRAVNGG 80


                 ....*...
gi 26334641  647 GESSLSEE 654
Cdd:cd00063   81 GESPPSES 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 762-850 3.36e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIET---TSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|..
gi 26334641  839 EGVRSMPISILT 850
Cdd:cd00063   82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
857-934 1.44e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLK-----TINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpwneiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 26334641    932 DGK 934
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 951-1049 8.85e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQnftllEVTQEPGNVTvSARIYKLAVFSYYTFWLT 1030
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK-----EVEVTPGSET-SYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*....
gi 26334641 1031 ASTLVGNGnKSSDVIHVYT 1049
Cdd:cd00063   76 AVNGGGES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 308-393 6.93e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELY----GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAG 382
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYRekgsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|.
gi 26334641  383 VGPKSNLSVFT 393
Cdd:cd00063   82 ESPPSESVTVT 92
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
76-441 5.50e-05

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 5.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   76 SWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA 155
Cdd:COG3401    1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  156 PGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPS 235
Cdd:COG3401   81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  236 PTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVR-TPESVPEGPPQNCI 314
Cdd:COG3401  161 SSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  315 TGNVTGKAFSISWDPPAI--VTGKFSYRVELYGPTGRILdNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV-GPKSN-LS 390
Cdd:COG3401  241 ATADTPGSVTLSWDPVTEsdATGYRVYRSNSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNvVS 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 26334641  391 VFTPPDVPGAVFDLQIVEVEATEIRVSWRKPrqPNGIISQYRVKVSVLESG 441
Cdd:COG3401  320 VTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGG 368
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
668-747 1.70e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 1.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNT-----STTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    743 HGNQS 747
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 57-151 5.53e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 5.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRakPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP--GSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 26334641  137 SAGIGVFSDPFLFQT 151
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 668-755 1.54e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADA-----LFVKNTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|...
gi 26334641  743 HGNQSSSlLSVRT 755
Cdd:cd00063   82 ESPPSES-VTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 570-654 5.72e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 5.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTV---DNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpgsETSYTLTGLKPGTEYEFRVRAVNGG 80


                 ....*...
gi 26334641  647 GESSLSEE 654
Cdd:cd00063   81 GESPPSES 88
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 57-141 1.94e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.48  E-value: 1.94e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641      57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRiiSYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 26334641     137 SAGIG 141
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
58-144 2.03e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 2.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     58 GPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVcpWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENS 137
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK--NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 26334641    138 AGIGVFS 144
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 762-850 3.36e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIET---TSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|..
gi 26334641  839 EGVRSMPISILT 850
Cdd:cd00063   82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 668-744 3.65e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 3.65e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     668 SSPQDVKVTDVSPSELSLTWSPPEKPNGI--IIAYEVFYQNADALFVK---NTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEvnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 26334641     743 HG 744
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
571-652 3.78e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    571 SSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTVDN---SFLITGLKKYTRYKMRVAASTHVG 647
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGtttSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    648 ESSLS 652
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
857-934 1.44e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLK-----TINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpwneiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 26334641    932 DGK 934
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 570-649 8.29e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 8.29e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     570 PSSIQIINYKNISSSSILLYWDPPEYPN--GKITHYTIYAMELDTN-RAFQMTTVDNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 26334641     647 GES 649
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 857-944 1.97e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDK-----VSLKTINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgsgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|...
gi 26334641  932 DGKtRSSVINFRT 944
Cdd:cd00063   82 ESP-PSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 951-1049 8.85e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQnftllEVTQEPGNVTvSARIYKLAVFSYYTFWLT 1030
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK-----EVEVTPGSET-SYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*....
gi 26334641 1031 ASTLVGNGnKSSDVIHVYT 1049
Cdd:cd00063   76 AVNGGGES-PPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
536-913 1.69e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  536 RLVPFTEHTISVSAFTVMGEGPP-TVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPEYPNgkITHYTIYAMELDTNR 614
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  615 AFQMTTV-DNSFLITGLKKYTRYKMRVAASTHVG-ESSLSEENDLfvrTPEDEPESSPQDVKVTDVSPSELSLTWSPPek 692
Cdd:COG3401  276 FTKVATVtTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSV---TTDLTPPAAPSGLTATAVGSSSITLSWTAS-- 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  693 PNGIIIAYEVFYQNADALFV----KNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLSVRTSETVPDSAPENIT 768
Cdd:COG3401  351 SDADVTGYNVYRSTSGGGTYtkiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASV 430

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  769 YKNISSEEIEIFFLPPRSPNGIIQKYTIYLK----RSNSHEARTIETTSLTLTIGGLKKYTHYVIEVSASTLKGEGVRSM 844
Cdd:COG3401  431 DAVPLTDVAGATAAASAASNPGVSAAVLADGgdtgNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVS 510

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26334641  845 PISILTEEDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLKTINANEVSLELSD 913
Cdd:COG3401  511 VIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGG 579
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 308-393 6.93e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELY----GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAG 382
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYRekgsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|.
gi 26334641  383 VGPKSNLSVFT 393
Cdd:cd00063   82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
762-843 3.07e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEA---RTIETTSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    839 EGVRS 843
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
951-1041 3.85e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSStfvqnfTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLT 1030
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS------GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 26334641   1031 ASTLVGNGNKS 1041
Cdd:pfam00041   75 AVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
308-387 1.82e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELYGPTG------RILDNSTKdlRFVFTHLTPFTMYDVYVAAETS 380
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPItGYEVEYRPKNSgepwneITVPGTTT--SVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 26334641    381 AGVGPKS 387
Cdd:pfam00041   79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 308-384 2.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.41e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     308 GPPQNCITGNVTGKAFSISWDPPAiVTGKFSYRVELY------GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSA 381
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRveyreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 26334641     382 GVG 384
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 762-840 2.93e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.93e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     762 SAPENITYKNISSEEIEIFFLPPRSPNGI--IQKYTIYLKRSNSHEARTIETTSLT-LTIGGLKKYTHYVIEVSASTLKG 838
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 26334641     839 EG 840
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
26-166 5.61e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   26 DDTVYDITLSSISATTYSSPVSRTLA--TNVSKPGPPVFLAGERVGSAGILLSWNtpPNPNGRIISYVVKYKEvcpWMQT 103
Cdd:COG3401  294 NGTTYYYRVTAVDAAGNESAPSNVVSvtTDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNVYRST---SGGG 368

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26334641  104 AYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGI-GVFSDPFLFQTAESAPGKVVNLTVEA 166
Cdd:COG3401  369 TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDA 432
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 857-933 1.95e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.95e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGI--ILYYTVYVWDKVSLK---TINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 26334641     932 DG 933
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 951-1038 2.89e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 2.89e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIiqYYSVYYQNTSSTFVQNFTLLEVTQEPGNVTVSariyKLAVFSYYTFWLT 1030
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLT----GLKPGTEYEFRVR 75


                    ....*...
gi 26334641    1031 ASTLVGNG 1038
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
76-441 5.50e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 5.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   76 SWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA 155
Cdd:COG3401    1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  156 PGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPS 235
Cdd:COG3401   81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  236 PTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVR-TPESVPEGPPQNCI 314
Cdd:COG3401  161 SSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  315 TGNVTGKAFSISWDPPAI--VTGKFSYRVELYGPTGRILdNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV-GPKSN-LS 390
Cdd:COG3401  241 ATADTPGSVTLSWDPVTEsdATGYRVYRSNSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNvVS 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 26334641  391 VFTPPDVPGAVFDLQIVEVEATEIRVSWRKPrqPNGIISQYRVKVSVLESG 441
Cdd:COG3401  320 VTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGG 368
fn3 pfam00041
Fibronectin type III domain;
399-441 7.32e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 7.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 26334641    399 GAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 398-441 1.90e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.90e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 26334641  398 PGAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG 44
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
668-747 1.70e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 1.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNT-----STTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    743 HGNQS 747
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 57-151 5.53e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 5.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRakPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP--GSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 26334641  137 SAGIGVFSDPFLFQT 151
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 668-755 1.54e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  668 SSPQDVKVTDVSPSELSLTWSPPEKPNGIIIAYEVFYQNADA-----LFVKNTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|...
gi 26334641  743 HGNQSSSlLSVRT 755
Cdd:cd00063   82 ESPPSES-VTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 570-654 5.72e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 5.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  570 PSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTV---DNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpgsETSYTLTGLKPGTEYEFRVRAVNGG 80


                 ....*...
gi 26334641  647 GESSLSEE 654
Cdd:cd00063   81 GESPPSES 88
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 57-141 1.94e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.48  E-value: 1.94e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641      57 PGPPVFLAGERVGSAGILLSWNTPPNPNGRiiSYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAEN 136
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 26334641     137 SAGIG 141
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
58-144 2.03e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 2.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     58 GPPVFLAGERVGSAGILLSWNTPPNPNGRIISYVVKYKEVcpWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENS 137
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK--NSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 26334641    138 AGIGVFS 144
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 762-850 3.36e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIET---TSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|..
gi 26334641  839 EGVRSMPISILT 850
Cdd:cd00063   82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 668-744 3.65e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 3.65e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     668 SSPQDVKVTDVSPSELSLTWSPPEKPNGI--IIAYEVFYQNADALFVK---NTSTTNITLSDLKPYTLYNISIQSYTRLG 742
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEvnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 26334641     743 HG 744
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
571-652 3.78e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 3.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    571 SSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTVDN---SFLITGLKKYTRYKMRVAASTHVG 647
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGtttSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    648 ESSLS 652
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
857-934 1.44e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLK-----TINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpwneiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 26334641    932 DGK 934
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 570-649 8.29e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 8.29e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     570 PSSIQIINYKNISSSSILLYWDPPEYPN--GKITHYTIYAMELDTN-RAFQMTTVDNSFLITGLKKYTRYKMRVAASTHV 646
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 26334641     647 GES 649
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 857-944 1.97e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDK-----VSLKTINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgsgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|...
gi 26334641  932 DGKtRSSVINFRT 944
Cdd:cd00063   82 ESP-PSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 951-1049 8.85e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 8.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQnftllEVTQEPGNVTvSARIYKLAVFSYYTFWLT 1030
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK-----EVEVTPGSET-SYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*....
gi 26334641 1031 ASTLVGNGnKSSDVIHVYT 1049
Cdd:cd00063   76 AVNGGGES-PPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
536-913 1.69e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  536 RLVPFTEHTISVSAFTVMGEGPP-TVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPEYPNgkITHYTIYAMELDTNR 614
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGP 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  615 AFQMTTV-DNSFLITGLKKYTRYKMRVAASTHVG-ESSLSEENDLfvrTPEDEPESSPQDVKVTDVSPSELSLTWSPPek 692
Cdd:COG3401  276 FTKVATVtTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSV---TTDLTPPAAPSGLTATAVGSSSITLSWTAS-- 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  693 PNGIIIAYEVFYQNADALFV----KNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLSVRTSETVPDSAPENIT 768
Cdd:COG3401  351 SDADVTGYNVYRSTSGGGTYtkiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASV 430

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  769 YKNISSEEIEIFFLPPRSPNGIIQKYTIYLK----RSNSHEARTIETTSLTLTIGGLKKYTHYVIEVSASTLKGEGVRSM 844
Cdd:COG3401  431 DAVPLTDVAGATAAASAASNPGVSAAVLADGgdtgNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVS 510

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26334641  845 PISILTEEDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLKTINANEVSLELSD 913
Cdd:COG3401  511 VIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGG 579
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 308-393 6.93e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELY----GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAG 382
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYRekgsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                         90
                 ....*....|.
gi 26334641  383 VGPKSNLSVFT 393
Cdd:cd00063   82 ESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
707-1061 1.20e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 55.78  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  707 ADALFVKNTSTTNITLSDLKPYTLYNISIQSYTrLGHGNQSSSLLSVRTSETVPdSAPENITYKNISSEEIEIFFLPprS 786
Cdd:COG3401  181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATD-TGGESAPSNEVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDP--V 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  787 PNGIIQKYTIYLKRSNSHEARTI-ETTSLTLTIGGLKKYTHYVIEVSASTLKG-EGVRSMPISILTEEDAPdSPPQNFSV 864
Cdd:COG3401  257 TESDATGYRVYRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP-AAPSGLTA 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  865 KQLSGVTVMLSWQPPLEPNgiILYYTVYVWDKVSLKTI----NANEVSLELSDLDYHADYSAYVTASTRFGDGKTRSSVI 940
Cdd:COG3401  336 TAVGSSSITLSWTASSDAD--VTGYNVYRSTSGGGTYTkiaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEV 413

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  941 NFRT---PEGEPSDPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTFVQNFTLLEVTQE---------PG 1008
Cdd:COG3401  414 SATTasaASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTdtttanlsvTT 493

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 26334641 1009 NVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDISVFGMQWK 1061
Cdd:COG3401  494 GSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVL 546
fn3 pfam00041
Fibronectin type III domain;
762-843 3.07e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    762 SAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEA---RTIETTSLTLTIGGLKKYTHYVIEVSASTLKG 838
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 26334641    839 EGVRS 843
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
951-1041 3.85e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSStfvqnfTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLT 1030
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS------GEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 26334641   1031 ASTLVGNGNKS 1041
Cdd:pfam00041   75 AVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
308-387 1.82e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641    308 GPPQNCITGNVTGKAFSISWDPPAIVTGKF-SYRVELYGPTG------RILDNSTKdlRFVFTHLTPFTMYDVYVAAETS 380
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPItGYEVEYRPKNSgepwneITVPGTTT--SVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 26334641    381 AGVGPKS 387
Cdd:pfam00041   79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 308-384 2.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.41e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     308 GPPQNCITGNVTGKAFSISWDPPAiVTGKFSYRVELY------GPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSA 381
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRveyreeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 26334641     382 GVG 384
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 762-840 2.93e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.93e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     762 SAPENITYKNISSEEIEIFFLPPRSPNGI--IQKYTIYLKRSNSHEARTIETTSLT-LTIGGLKKYTHYVIEVSASTLKG 838
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 26334641     839 EG 840
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
26-166 5.61e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   26 DDTVYDITLSSISATTYSSPVSRTLA--TNVSKPGPPVFLAGERVGSAGILLSWNtpPNPNGRIISYVVKYKEvcpWMQT 103
Cdd:COG3401  294 NGTTYYYRVTAVDAAGNESAPSNVVSvtTDLTPPAAPSGLTATAVGSSSITLSWT--ASSDADVTGYNVYRST---SGGG 368

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26334641  104 AYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGI-GVFSDPFLFQTAESAPGKVVNLTVEA 166
Cdd:COG3401  369 TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDA 432
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 857-933 1.95e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.95e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     857 SPPQNFSVKQLSGVTVMLSWQPPLEPNGI--ILYYTVYVWDKVSLK---TINANEVSLELSDLDYHADYSAYVTASTRFG 931
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 26334641     932 DG 933
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 951-1038 2.89e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 2.89e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     951 DPPKDVHYVNLSSSSIILFWTPPVKPNGIiqYYSVYYQNTSSTFVQNFTLLEVTQEPGNVTVSariyKLAVFSYYTFWLT 1030
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLT----GLKPGTEYEFRVR 75


                    ....*...
gi 26334641    1031 ASTLVGNG 1038
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
76-441 5.50e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 5.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   76 SWNTPPNPNGRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESA 155
Cdd:COG3401    1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  156 PGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLSGKLPECNENSDSFLWSTTSPS 235
Cdd:COG3401   81 AVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  236 PTLSRATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVR-TPESVPEGPPQNCI 314
Cdd:COG3401  161 SSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvTTPTTPPSAPTGLT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  315 TGNVTGKAFSISWDPPAI--VTGKFSYRVELYGPTGRILdNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV-GPKSN-LS 390
Cdd:COG3401  241 ATADTPGSVTLSWDPVTEsdATGYRVYRSNSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNvVS 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 26334641  391 VFTPPDVPGAVFDLQIVEVEATEIRVSWRKPrqPNGIISQYRVKVSVLESG 441
Cdd:COG3401  320 VTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGG 368
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
531-774 1.12e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  531 SYVIRRLVPFTEHTISVSAFTVMGE--GPPTVLTVRTREQVPSSIQIINYKNISSSSILLYWDPPeyPNGKITHYTIYAm 608
Cdd:COG3401  286 SYTDTGLTNGTTYYYRVTAVDAAGNesAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR- 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  609 elDTNRAFQMTTV-----DNSFLITGLKKYTRYKMRVAASTHVG-ESSLSEE---NDLFVRTPEDEPESSPQDVKVTDVS 679
Cdd:COG3401  363 --STSGGGTYTKIaetvtTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEvsaTTASAASGESLTASVDAVPLTDVAG 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  680 PSELSLTWSPPEKPNGIIIAYEV--FYQNADALFVKNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLSVRTSE 757
Cdd:COG3401  441 ATAAASAASNPGVSAAVLADGGDtgNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAV 520

                        250
                 ....*....|....*..
gi 26334641  758 TVPDSAPENITYKNISS 774
Cdd:COG3401  521 GGAPDGTPNVTGASPVT 537
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 75-151 4.62e-04

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 40.47  E-value: 4.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641     75 LSWNTPPNPNGRIISYVVKYKEVCPWM---QTAYTRVRAKPDSL-EVLLTNLNPGTTYEIKVAAENSagigVFSDPFLFQ 150
Cdd:pfam16656   17 VSWVTPSAVTSPVVQYGTSSSALTSTAtatSSTYTTGDGGTGYIhRATLTGLEPGTTYYYRVGDDNG----GWSEVYSFT 92


                   .
gi 26334641    151 T 151
Cdd:pfam16656   93 T 93
fn3 pfam00041
Fibronectin type III domain;
399-441 7.32e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 7.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 26334641    399 GAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG 43
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
13-417 1.31e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.68  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   13 GTSESQVDVSGSFDDTVYDITLSSISATTYSSPVSRTLATNVSKPGPPVFLAGERVGSAGIllSWNTPPNPNGRIISYVV 92
Cdd:COG3401   91 ATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVD--GANASGTTASSVAGAGV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641   93 KYKEVCPWMQTAYTRVRAKPDSLEVLLT-NLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEALNYSA 171
Cdd:COG3401  169 VVSPDTSATAAVATTSLTVTSTTLVDGGgDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGS 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  172 VNLIWylPRQPNGKITSFKISVKharsgivvkdvsikvedllsgklpecnensdsflwstTSPSPTLSRATpplrtthls 251
Cdd:COG3401  249 VTLSW--DPVTESDATGYRVYRS-------------------------------------NSGDGPFTKVA--------- 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  252 nTLARNkissvwkepiSFVVTHLRPYTTYLFEVSAVTTeAGYI--DSTIVR-TPESVPEGPPQNCITGNVTGKAFSISWD 328
Cdd:COG3401  281 -TVTTT----------SYTDTGLTNGTTYYYRVTAVDA-AGNEsaPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWT 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334641  329 PPAI--VTGKFSYRVELYGPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV--GPKSNLSVFTPPDVPGAVFDL 404
Cdd:COG3401  349 ASSDadVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVSATTASAASGESLTA 428

                        410
                 ....*....|...
gi 26334641  405 QIVEVEATEIRVS 417
Cdd:COG3401  429 SVDAVPLTDVAGA 441
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 398-441 1.90e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.63  E-value: 1.90e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 26334641  398 PGAVFDLQIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVLESG 441
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSG 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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