NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|26344648|dbj|BAC35973|]
View 

unnamed protein product [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
198-322 1.32e-14

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 198 SPDastGNYIAVGNMTPVIEVWDldiVDSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWNKTvRNVLASASAD 277
Cdd:COG2319 297 SPD---GKLLASGSDDGTVRLWD---LATGKLLRTL------------------TGHTGAVRSVAFSPD-GKTLASGSDD 351

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26344648 278 STVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR 322
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGT 395
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
198-322 1.32e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 198 SPDastGNYIAVGNMTPVIEVWDldiVDSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWNKTvRNVLASASAD 277
Cdd:COG2319 297 SPD---GKLLASGSDDGTVRLWD---LATGKLLRTL------------------TGHTGAVRSVAFSPD-GKTLASGSDD 351

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26344648 278 STVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR 322
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-321 1.94e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 1.94e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDN 321
Cdd:cd00200 132 RGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDG 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 252-284 7.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.81e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 26344648    252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 284
Cdd:smart00320   9 KGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 252-307 1.43e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 1.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 26344648  252 EGHTDAVLDLSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFH 307
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
WD40 pfam00400
WD domain, G-beta repeat;
252-284 6.56e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 6.56e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 26344648   252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 284
Cdd:pfam00400   8 EGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
198-322 1.32e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 198 SPDastGNYIAVGNMTPVIEVWDldiVDSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWNKTvRNVLASASAD 277
Cdd:COG2319 297 SPD---GKLLASGSDDGTVRLWD---LATGKLLRTL------------------TGHTGAVRSVAFSPD-GKTLASGSDD 351

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26344648 278 STVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR 322
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
183-322 9.95e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 9.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 183 LSAYPLSVEWLNFdpSPDastGNYIAVGNMTPVIEVWDldiVDSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLS 262
Cdd:COG2319 158 LTGHSGAVTSVAF--SPD---GKLLASGSDDGTVRLWD---LATGKLLRTL------------------TGHTGAVRSVA 211

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 263 WNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR 322
Cdd:COG2319 212 FSPD-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGT 269
WD40 COG2319
WD40 repeat [General function prediction only];
183-322 9.95e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 9.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 183 LSAYPLSVEWLNFdpSPDastGNYIAVGNMTPVIEVWDldiVDSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLS 262
Cdd:COG2319 200 LTGHTGAVRSVAF--SPD---GKLLASGSADGTVRLWD---LATGKLLRTL------------------TGHSGSVRSVA 253

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26344648 263 WN---KTvrnvLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR 322
Cdd:COG2319 254 FSpdgRL----LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGT 311
WD40 COG2319
WD40 repeat [General function prediction only];
198-341 1.57e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 198 SPDastGNYIAVGNMTPVIEVWDLDivdSLEPVFTlgsklskkkkkkgkksssAEGHTDAVLDLSWN---KTvrnvLASA 274
Cdd:COG2319 129 SPD---GKTLASGSADGTVRLWDLA---TGKLLRT------------------LTGHSGAVTSVAFSpdgKL----LASG 180

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 275 SADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR---WLCMTAEIPARTTASGGSV 341
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTvrlWDLATGKLLRTLTGHSGSV 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-321 1.94e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 1.94e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDN 321
Cdd:cd00200 132 RGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDG 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-322 2.73e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 2.73e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26344648 252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR 322
Cdd:cd00200 216 RGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGT 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-321 4.57e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 4.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 202 STGNYIAVGNMTPVIEVWDLDivdSLEPVFTlgsklskkkkkkgkksssAEGHTDAVLDLSWNKTvRNVLASASADSTVV 281
Cdd:cd00200  61 ADGTYLASGSSDKTIRLWDLE---TGECVRT------------------LTGHTSYVSSVAFSPD-GRILSSSSRDKTIK 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 26344648 282 LWDLSVGKSVARLTAHTDKVQTLQFHPFEaQTLISGSYDN 321
Cdd:cd00200 119 VWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDG 157
WD40 COG2319
WD40 repeat [General function prediction only];
252-341 1.74e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 252 EGHTDAVLDLSWN---KTvrnvLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDNR---WLC 325
Cdd:COG2319 117 TGHTGAVRSVAFSpdgKT----LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTvrlWDL 191

                        90
                ....*....|....*.
gi 26344648 326 MTAEIPARTTASGGSV 341
Cdd:COG2319 192 ATGKLLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-321 6.65e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 6.65e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 252 EGHTDAVLDLSWNkTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFeAQTLISGSYDN 321
Cdd:cd00200   6 KGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDK 73
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-321 4.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 4.65e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDN 321
Cdd:cd00200 174 TGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 252-284 7.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.81e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 26344648    252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 284
Cdd:smart00320   9 KGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 252-307 1.43e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 1.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 26344648  252 EGHTDAVLDLSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFH 307
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
WD40 pfam00400
WD domain, G-beta repeat;
252-284 6.56e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 6.56e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 26344648   252 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 284
Cdd:pfam00400   8 EGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 252-323 6.68e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 6.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648  252 EGHTDAVLDLSWNKTVRNVLASASADSTVVLWDL--------SVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYD--- 320
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDsfv 150


                 ...
gi 26344648  321 NRW 323
Cdd:PTZ00420 151 NIW 153
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 189-284 1.27e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 189 SVEWLNFDPSpdastGNYIAVGNMTPVIEVWDLDivdSLEPVFTlgsklskkkkkkgkksssAEGHTDAVLDLSWNKTvR 268
Cdd:cd00200 221 GVNSVAFSPD-----GYLLASGSEDGTIRVWDLR---TGECVQT------------------LSGHTNSVTSLAWSPD-G 273

                        90
                ....*....|....*.
gi 26344648 269 NVLASASADSTVVLWD 284
Cdd:cd00200 274 KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
198-286 2.58e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26344648 198 SPDastGNYIAVGNMTPVIEVWDLDivdSLEPVFTLgsklskkkkkkgkksssaEGHTDAVLDLSWNKTVRnVLASASAD 277
Cdd:COG2319 339 SPD---GKTLASGSDDGTVRLWDLA---TGELLRTL------------------TGHTGAVTSVAFSPDGR-TLASGSAD 393


                ....*....
gi 26344648 278 STVVLWDLS 286
Cdd:COG2319 394 GTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 288-321 5.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 26344648    288 GKSVARLTAHTDKVQTLQFHPFEaQTLISGSYDN 321
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH