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Conserved domains on  [gi|74185613|dbj|BAE32697|]
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unnamed protein product [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1019192)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
365-745 1.15e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 1.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 443
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  444 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 523
Cdd:COG2319  150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  524 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 602
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  603 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 682
Cdd:COG2319  267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74185613  683 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
94-445 1.07e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 1.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   94 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 173
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  174 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 251
Cdd:COG2319  222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  252 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 329
Cdd:COG2319  290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  330 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 409
Cdd:COG2319  324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 74185613  410 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 445
Cdd:COG2319  377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 984-1451 2.13e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.46  E-value: 2.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613    984 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAGKPEYPSteelSQ 1059
Cdd:pfam03154  128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATAGPTP----SA 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1060 PELPGLGNGSLPQTPEQEKflrhhfetltdapteelfhGSLGDIKISETEDYFFNPRLSISTqflSRLQKTSRCPPrlPL 1139
Cdd:pfam03154  204 PSVPPQGSPATSQPPNQTQ-------------------STAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPP--PS 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1140 HLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSISAPSSCSY 1219
Cdd:pfam03154  260 QVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIHTPPSQSQ 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1220 LES-------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDHEPAplsw 1284
Cdd:pfam03154  334 LQSqqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTHHPP---- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1285 gnheARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLHSSMFLPK 1357
Cdd:pfam03154  409 ----SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITPPSGPPTS 484

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1358 TSASGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRLQTA-FQE 1430
Cdd:pfam03154  485 TSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHASQSArFYK 561

                          490       500       510
                   ....*....|....*....|....*....|.
gi 74185613   1431 AL----------DLYRMLVSSSQLGPEQQQA 1451
Cdd:pfam03154  562 HLdrgynscartDLYFMPLAGSKLAKKREEA 592
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
365-745 1.15e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 1.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 443
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  444 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 523
Cdd:COG2319  150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  524 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 602
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  603 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 682
Cdd:COG2319  267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74185613  683 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 365-743 3.01e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 3.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqRACLPSGTFLTCSSDNTIRFWNLD 444
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDV---------AASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  445 SASDTRwqknIFsdsllkvvyvendIQHLQDlshfpdrgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELHF 524
Cdd:cd00200   82 TGECVR----TL-------------TGHTSY--------------------VSSVAFSPDGRILSSSSRDKTIKVWDVET 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  525 MDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEKNYnLEQTLDDHSSSITAIKFAGTRDvQMISCGADK 604
Cdd:cd00200  125 GKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE-KLLSSSSDG 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  605 SIyfrsaqqasdglhfvrthhvaekttlydmdiditqkyvavacqdrnvRVYNTVSGKQKKCYkgsQGDEGSLLKVHVDP 684
Cdd:cd00200  200 TI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSVAFSP 229

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74185613  685 SGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
94-445 1.07e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 1.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   94 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 173
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  174 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 251
Cdd:COG2319  222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  252 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 329
Cdd:COG2319  290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  330 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 409
Cdd:COG2319  324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 74185613  410 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 445
Cdd:COG2319  377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-442 2.54e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.03  E-value: 2.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  112 RKSLSALAFSPDGKYIVTG-ENGhrpTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKD 190
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGsGDG---TIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  191 IVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVTSTvplvgrsgilgelHNN-IFCGVACGRGRMA 267
Cdd:cd00200   84 ECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRG-------------HTDwVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  268 gntFCVSYSGL-----LCQFNEKRVL---DKWINlkvslssCLCVSD--ELIFCGCTDGIVRIFqahsllyltNLPKPHY 337
Cdd:cd00200  151 ---ASSSQDGTiklwdLRTGKCVATLtghTGEVN-------SVAFSPdgEKLLSSSSDGTIKLW---------DLSTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  338 LGVDVAHGldssflfhrkaEAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypef 417
Cdd:cd00200  212 LGTLRGHE-----------NGVN----SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL------ 267

                        330       340
                 ....*....|....*....|....*.
gi 74185613  418 edqrACLPSGTFL-TCSSDNTIRFWN 442
Cdd:cd00200  268 ----AWSPDGKRLaSGSADGTIRIWD 289
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 984-1451 2.13e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.46  E-value: 2.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613    984 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAGKPEYPSteelSQ 1059
Cdd:pfam03154  128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATAGPTP----SA 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1060 PELPGLGNGSLPQTPEQEKflrhhfetltdapteelfhGSLGDIKISETEDYFFNPRLSISTqflSRLQKTSRCPPrlPL 1139
Cdd:pfam03154  204 PSVPPQGSPATSQPPNQTQ-------------------STAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPP--PS 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1140 HLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSISAPSSCSY 1219
Cdd:pfam03154  260 QVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIHTPPSQSQ 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1220 LES-------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDHEPAplsw 1284
Cdd:pfam03154  334 LQSqqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTHHPP---- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1285 gnheARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLHSSMFLPK 1357
Cdd:pfam03154  409 ----SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITPPSGPPTS 484

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1358 TSASGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRLQTA-FQE 1430
Cdd:pfam03154  485 TSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHASQSArFYK 561

                          490       500       510
                   ....*....|....*....|....*....|.
gi 74185613   1431 AL----------DLYRMLVSSSQLGPEQQQA 1451
Cdd:pfam03154  562 HLdrgynscartDLYFMPLAGSKLAKKREEA 592
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 705-744 2.87e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 74185613     705 SGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWH 744
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
706-743 1.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 74185613    706 GECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-142 2.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 74185613     103 KQQHIFNTTRKSLSALAFSPDGKYIVTG-ENGhrpTVRIWD 142
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGsDDG---TIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
102-142 4.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 4.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 74185613    102 NKQQHIFNTTRKSLSALAFSPDGKYIVTG-ENGhrpTVRIWD 142
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGsDDG---TVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
365-745 1.15e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 1.15e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNL 443
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSV----------AFSPDGKTLaSGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  444 DSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELH 523
Cdd:COG2319  150 ATG------------------------KLLRTLTGHSGA-------------VTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  524 FMDELIKVEAHDAEVLCLEYSkPEtGvTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFagTRDVQMI-SCGA 602
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFS-PD-G-KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAF--SPDGRLLaSGSA 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  603 DKSIYFRSAQqaSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHV 682
Cdd:COG2319  267 DGTVRLWDLA--TGELLRTLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAF 338

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74185613  683 DPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 365-743 3.01e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 3.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  365 ALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypefedqRACLPSGTFLTCSSDNTIRFWNLD 444
Cdd:cd00200   14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDV---------AASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  445 SASDTRwqknIFsdsllkvvyvendIQHLQDlshfpdrgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRIHELHF 524
Cdd:cd00200   82 TGECVR----TL-------------TGHTSY--------------------VSSVAFSPDGRILSSSSRDKTIKVWDVET 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  525 MDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEKNYnLEQTLDDHSSSITAIKFAGTRDvQMISCGADK 604
Cdd:cd00200  125 GKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE-KLLSSSSDG 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  605 SIyfrsaqqasdglhfvrthhvaekttlydmdiditqkyvavacqdrnvRVYNTVSGKQKKCYkgsQGDEGSLLKVHVDP 684
Cdd:cd00200  200 TI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSVAFSP 229

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74185613  685 SGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 493-745 4.53e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 4.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  493 KAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKpetGVTLLASASRDRLIHVLNVEKNyN 572
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLWDLETG-E 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  573 LEQTLDDHSSSITAIKFAGTRDVqMISCGADKSIyfRSAQQASDGLHFVRTHHvaeKTTLYDMDIDITQKYVAVACQDRN 652
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTI--KVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  653 VRVYNTVSGKqkkCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLI 732
Cdd:cd00200  159 IKLWDLRTGK---CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                        250
                 ....*....|...
gi 74185613  733 TVSGDSCVFIWHL 745
Cdd:cd00200  236 SGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
43-568 2.28e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 2.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   43 LRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSP 122
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  123 DGKYIVTGenGHRPTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHdmVLNVWDWKKDIVVAS-NKVSCR 201
Cdd:COG2319   89 DGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  202 VIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVtstvpLVGrsgilgelHNNIFCGVAcgrgrmagntfcVSYSGllc 280
Cdd:COG2319  165 VTSVAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTG--------HTGAVRSVA------------FSPDG--- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  281 qfnekrvldkwinlkvslssclcvsdELIFCGCTDGIVRIFQAHSLLYLTNLPkphylgvdvAHGldssflfhrkaEAVY 360
Cdd:COG2319  217 --------------------------KLLASGSADGTVRLWDLATGKLLRTLT---------GHS-----------GSVR 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  361 pdtvALTFDPVHQWLSCVYKDHSIYIWDVKDiDEVSKIWSElfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIR 439
Cdd:COG2319  251 ----SVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTG--HSGGVNSV----------AFSPDGKLLaSGSDDGTVR 313

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  440 FWNLDSAsdtrwqknifsdsllkvvyvendiQHLQDLSHFPDRgsengtpmdmkagVRVMQVSPDGQHLASGDRSGNLRI 519
Cdd:COG2319  314 LWDLATG------------------------KLLRTLTGHTGA-------------VRSVAFSPDGKTLASGSDDGTVRL 356

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 74185613  520 HELHFMDELIKVEAHDAEVLCLEYSKPEtgvTLLASASRDRLIHVLNVE 568
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDG---RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 534-743 2.89e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 2.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  534 HDAEVLCLEYSkpeTGVTLLASASRDRLIHVLNVEKNyNLEQTLDDHSSSITAIKFAGTRDvQMISCGADKSIYFrsaqQ 613
Cdd:cd00200    8 HTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL----W 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  614 ASDGLHFVRTHHVAEKTtLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDegsLLKVHVDPSGTFLATSC 693
Cdd:cd00200   79 DLETGECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPDGTFVASSS 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 74185613  694 SDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
94-445 1.07e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 1.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   94 VVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGenGHRPTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVS 173
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  174 MGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWflEASTEAKVTStvpLVGRSGilgel 251
Cdd:COG2319  222 GSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSaDGTVRLW--DLATGELLRT---LTGHSG----- 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  252 hnnifcgvacgrgrmagntfcvsysgllcqfnekrvldkWINlkvslssCLCVS--DELIFCGCTDGIVRIFQAHSLLYL 329
Cdd:COG2319  290 ---------------------------------------GVN-------SVAFSpdGKLLASGSDDGTVRLWDLATGKLL 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  330 TNLpKPHYLGVDvahgldssflfhrkaeavypdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVW 409
Cdd:COG2319  324 RTL-TGHTGAVR-----------------------SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG---HTGAVT 376

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 74185613  410 NVevypefedqrACLPSGTFL-TCSSDNTIRFWNLDS 445
Cdd:COG2319  377 SV----------AFSPDGRTLaSGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
3-519 1.62e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613    3 AALAAGGYTRSDTIEKLSSVMAGVPARRNQSSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPG 82
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   83 TGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHrpTVRIWDVEEKTQVAEMLGHKYGVACV 162
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  163 AFSPNMKHIVSMGYqhDMVLNVWDWKKDIVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVtstvp 240
Cdd:COG2319  169 AFSPDGKLLASGSD--DGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSaDGTVRLWDLATGKLLRT----- 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  241 LVGRSGILgelhnnifcgvacgrgrmagntFCVSYSGllcqfnekrvldkwinlkvslssclcvSDELIFCGCTDGIVRI 320
Cdd:COG2319  242 LTGHSGSV----------------------RSVAFSP---------------------------DGRLLASGSADGTVRL 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  321 FqahsllyltnlpkphylgvDVAHGLDSSFLFHRKAeAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWS 400
Cdd:COG2319  273 W-------------------DLATGELLRTLTGHSG-GVN----SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  401 elfHSSFVWNVevypefedqrACLPSGTFL-TCSSDNTIRFWNLdsasDTRWQKNIFSdsllkvvyvendiQHlqdlshf 479
Cdd:COG2319  329 ---HTGAVRSV----------AFSPDGKTLaSGSDDGTVRLWDL----ATGELLRTLT-------------GH------- 371

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|
gi 74185613  480 pdrgsengtpmdmKAGVRVMQVSPDGQHLASGDRSGNLRI 519
Cdd:COG2319  372 -------------TGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
481-751 2.14e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 2.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  481 DRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkPETgvTLLASASRDR 560
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDG--KTLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  561 LIHVLNVEKNyNLEQTLDDHSSSITAIKFA--GTRdvqMISCGADKSIYFRSAQQASDgLHFVRTHhvaeKTTLYDMDID 638
Cdd:COG2319  143 TVRLWDLATG-KLLRTLTGHSGAVTSVAFSpdGKL---LASGSDDGTVRLWDLATGKL-LRTLTGH----TGAVRSVAFS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  639 ITQKYVAVACQDRNVRVYNTVSGKQKKCYKGsqgDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEI 718
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 74185613  719 VTGMKFTYDCRHLITVSGDSCVFIWHL--GPEITT 751
Cdd:COG2319  291 VNSVAFSPDGKLLASGSDDGTVRLWDLatGKLLRT 325
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-442 2.54e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.03  E-value: 2.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  112 RKSLSALAFSPDGKYIVTG-ENGhrpTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKD 190
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGsGDG---TIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  191 IVVAS-NKVSCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASTEAKVTSTvplvgrsgilgelHNN-IFCGVACGRGRMA 267
Cdd:cd00200   84 ECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRG-------------HTDwVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  268 gntFCVSYSGL-----LCQFNEKRVL---DKWINlkvslssCLCVSD--ELIFCGCTDGIVRIFqahsllyltNLPKPHY 337
Cdd:cd00200  151 ---ASSSQDGTiklwdLRTGKCVATLtghTGEVN-------SVAFSPdgEKLLSSSSDGTIKLW---------DLSTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  338 LGVDVAHGldssflfhrkaEAVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSelfHSSFVWNVevypef 417
Cdd:cd00200  212 LGTLRGHE-----------NGVN----SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL------ 267

                        330       340
                 ....*....|....*....|....*.
gi 74185613  418 edqrACLPSGTFL-TCSSDNTIRFWN 442
Cdd:cd00200  268 ----AWSPDGKRLaSGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 300-606 1.13e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 1.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  300 SCLCVSD--ELIFCGCTDGIVRIFQAHSLLYLTNLpKPHYLGV-DVAHGLDSSFLF------------------------ 352
Cdd:cd00200   13 TCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVrDVAASADGTYLAsgssdktirlwdletgecvrtltg 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  353 HRKAeaVYpdtvALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIwseLFHSSFVWNVEVypefedqracLPSGTFLTC 432
Cdd:cd00200   92 HTSY--VS----SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL---RGHTDWVNSVAF----------SPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  433 SS-DNTIRFWNLDSasdtrwqknifsdsllkvvyvendiqhlqdlshfpdrGSENGTPMDMKAGVRVMQVSPDGQHLASG 511
Cdd:cd00200  153 SSqDGTIKLWDLRT-------------------------------------GKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  512 DRSGNLRIHELHfMDELIKV-EAHDAEVLCLEYSKPEtgvTLLASASRDRLIHVLNVEKNYNLeQTLDDHSSSITAIKFA 590
Cdd:cd00200  196 SSDGTIKLWDLS-TGKCLGTlRGHENGVNSVAFSPDG---YLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWS 270

                        330
                 ....*....|....*.
gi 74185613  591 GTRDVqMISCGADKSI 606
Cdd:cd00200  271 PDGKR-LASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-564 1.03e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  154 GHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWDWKKDIVVASNKV-SCRVIALSFSEDSSYFVTVG-NRHVRFWFLEASt 231
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSsDKTIRLWDLETG- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  232 eaKVTSTvpLVGrsgilgelHNnifcgvacgrgrmaGNTFCVSYSgllcqfnekrvldkwinlkvslssclcVSDELIFC 311
Cdd:cd00200   84 --ECVRT--LTG--------HT--------------SYVSSVAFS---------------------------PDGRILSS 110

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  312 GCTDGIVRIFQAHSLLYLTnlpkphylgvdvahgldsSFLFHRKaeavypDTVALTFDPVHQWLSCVYKDHSIYIWDVKD 391
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLT------------------TLRGHTD------WVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  392 IdevSKIWSELFHSSFVWNVEVYPEfedqraclpSGTFLTCSSDNTIRFWNLDSAsdtrwqknifsdsllkvvyvendiQ 471
Cdd:cd00200  167 G---KCVATLTGHTGEVNSVAFSPD---------GEKLLSSSSDGTIKLWDLSTG------------------------K 210

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  472 HLQDLshfpdRGSENgtpmdmkaGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkPETGVt 551
Cdd:cd00200  211 CLGTL-----RGHEN--------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS-PDGKR- 275

                        410
                 ....*....|...
gi 74185613  552 lLASASRDRLIHV 564
Cdd:cd00200  276 -LASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
481-751 1.02e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.03  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  481 DRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSkpeTGVTLLASASRDR 560
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS---PDGRLLASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  561 LIHVLNVEKNYNLeQTLDDHSSSITAIKFAgtrdvqmiscgadksiyfrsaqqaSDGlhfvrthhvaekttlydmdidit 640
Cdd:COG2319  101 TVRLWDLATGLLL-RTLTGHTGAVRSVAFS------------------------PDG----------------------- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  641 qKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSllkVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVT 720
Cdd:COG2319  133 -KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS---VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208

                        250       260       270
                 ....*....|....*....|....*....|...
gi 74185613  721 GMKFTYDCRHLITVSGDSCVFIWHL--GPEITT 751
Cdd:COG2319  209 SVAFSPDGKLLASGSADGTVRLWDLatGKLLRT 241
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-225 1.72e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   88 YLAGC----VVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHrpTVRIWDVEEKTQVAEMLGHKYGVACVA 163
Cdd:cd00200  107 ILSSSsrdkTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG--TIKLWDLRTGKCVATLTGHTGEVNSVA 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74185613  164 FSPNMKHIVSMGyqHDMVLNVWDWKKDIVVASNKVSC-RVIALSFSEDSSYFVTVG-NRHVRFW 225
Cdd:cd00200  185 FSPDGEKLLSSS--SDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGYLLASGSeDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 633-756 1.45e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613  633 YDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSqgdEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKM 712
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 74185613  713 FGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL-GPEITTCMKQH 756
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGH 134
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 984-1451 2.13e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.46  E-value: 2.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613    984 EETEAGPEDQQGDTYLRVSSVSS-KDQSPPEDSGESEAELECS---FAAAHSSAPQTDPGPHLTMTAGKPEYPSteelSQ 1059
Cdd:pfam03154  128 DEGSSDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILQTQppvLQAQSGAASPPSPPPPGTTQAATAGPTP----SA 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1060 PELPGLGNGSLPQTPEQEKflrhhfetltdapteelfhGSLGDIKISETEDYFFNPRLSISTqflSRLQKTSRCPPrlPL 1139
Cdd:pfam03154  204 PSVPPQGSPATSQPPNQTQ-------------------STAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPP--PS 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1140 HLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALslldrkPPTPTSVLTTGREQSISAPSSCSY 1219
Cdd:pfam03154  260 QVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV------PPGPSPAAPGQSQQRIHTPPSQSQ 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1220 LES-------------TTSSHAKTTRSISLGDSEGPVTAELPQSLHKPlSPGQELQAIPTTVALT--SSIKDHEPAplsw 1284
Cdd:pfam03154  334 LQSqqppreqplppapLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGP-SPFQMNSNLPPPPALKplSSLSTHHPP---- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1285 gnheARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEP--VDVPPSMAVTVASFCAPSP-----VDMSTLGLHSSMFLPK 1357
Cdd:pfam03154  409 ----SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaASHPPTSGLHQVPSQSPFPqhpfvPGGPPPITPPSGPPTS 484

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613   1358 TSASGPLTPPAHLQLLETRSRVPGSTAALLEPT------PDASGVIADSPGHWDTEVPTPELlgsVESVLHRLQTA-FQE 1430
Cdd:pfam03154  485 TSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeeaLDEAEEPESPPPPPRSPSPEPTV---VNTPSHASQSArFYK 561

                          490       500       510
                   ....*....|....*....|....*....|.
gi 74185613   1431 AL----------DLYRMLVSSSQLGPEQQQA 1451
Cdd:pfam03154  562 HLdrgynscartDLYFMPLAGSKLAKKREEA 592
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 705-744 2.87e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 74185613     705 SGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWH 744
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
706-743 1.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 74185613    706 GECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIW 743
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 635-727 3.26e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 3.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74185613    635 MDIditqkyVAVACQDRNVRVYNTvSGKqkKCYKGSQGDEGSLLK-VHVDPSGTFLATSCSDKSISLIDFYSGECVAKMF 713
Cdd:pfam12894    7 MDL------IALATEDGELLLHRL-NWQ--RVWTLSPDKEDLEVTsLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFS 77

                           90
                   ....*....|....
gi 74185613    714 GHSEIVTGMKFTYD 727
Cdd:pfam12894   78 AGSDLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 103-142 2.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 74185613     103 KQQHIFNTTRKSLSALAFSPDGKYIVTG-ENGhrpTVRIWD 142
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGsDDG---TIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-186 4.25e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 4.25e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 74185613     146 KTQVAEMLGHKYGVACVAFSPNMKHIVSMGYqhDMVLNVWD 186
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
102-142 4.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 4.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 74185613    102 NKQQHIFNTTRKSLSALAFSPDGKYIVTG-ENGhrpTVRIWD 142
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGsDDG---TVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 714-762 6.08e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 6.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 74185613  714 GHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL-GPEITTCMKQHLLEINH 762
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLeTGELLRTLKGHTGPVRD 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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