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Conserved domains on  [gi|194381934|dbj|BAG64336|]
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unnamed protein product [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12087049)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-460 1.16e-95

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 1.16e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 181 LLWEPL----------HAN--------PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQ 241
Cdd:COG2319  145 RLWDLAtgkllrtltgHSGavtsvafsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSA 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 242 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLV 321
Cdd:COG2319  225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR---LLA 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 322 SGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSAD 401
Cdd:COG2319  263 SGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934 402 SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 460
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 9.67e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 68.70  E-value: 9.67e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194381934   17 LLVQFQDEGGQL--LGSPFDVPVDITPDRLQLVCNALLAQED---PLPLAFFVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-460 1.16e-95

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 1.16e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 181 LLWEPL----------HAN--------PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQ 241
Cdd:COG2319  145 RLWDLAtgkllrtltgHSGavtsvafsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSA 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 242 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLV 321
Cdd:COG2319  225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR---LLA 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 322 SGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSAD 401
Cdd:COG2319  263 SGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934 402 SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 460
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-460 3.60e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 268.05  E-value: 3.60e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGckngqillwep 185
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 186 lhanpecryvassSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGH 264
Cdd:cd00200   70 -------------SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 265 WVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrgqgPERLVSGSDDFTLFLWSpAEDKKPLTRM 344
Cdd:cd00200  137 WVNSVAFSPD------------------------------------------GTFVASSSQDGTIKLWD-LRTGKCVATL 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 345 TGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 424
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 194381934 425 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 460
Cdd:cd00200  254 VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 9.67e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 68.70  E-value: 9.67e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194381934   17 LLVQFQDEGGQL--LGSPFDVPVDITPDRLQLVCNALLAQED---PLPLAFFVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-142 7.53e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 7.53e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 194381934   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
105-142 1.59e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.59e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 194381934  105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 317-432 7.10e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 7.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 317 PERLVSGSDDFTLFLWS-PAEDKK-----PLTRMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 389
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 194381934 390 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 432
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 114-172 4.42e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 39.18  E-value: 4.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934  114 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGRKLA 172
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLA 249
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
101-460 1.16e-95

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 294.13  E-value: 1.16e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 181 LLWEPL----------HAN--------PECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQ 241
Cdd:COG2319  145 RLWDLAtgkllrtltgHSGavtsvafsPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSA 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 242 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLV 321
Cdd:COG2319  225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD---------------------------------------GR---LLA 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 322 SGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSAD 401
Cdd:COG2319  263 SGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934 402 SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 460
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-460 3.60e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 268.05  E-value: 3.60e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGckngqillwep 185
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 186 lhanpecryvassSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGH 264
Cdd:cd00200   70 -------------SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 265 WVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrgqgPERLVSGSDDFTLFLWSpAEDKKPLTRM 344
Cdd:cd00200  137 WVNSVAFSPD------------------------------------------GTFVASSSQDGTIKLWD-LRTGKCVATL 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 345 TGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 424
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 194381934 425 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 460
Cdd:cd00200  254 VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
104-420 6.47e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 263.70  E-value: 6.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 104 TRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLW 183
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 184 -----EPLHA-------------NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRT 244
Cdd:COG2319  190 dlatgKLLRTltghtgavrsvafSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 245 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLVSGS 324
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPD---------------------------------------GK---LLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 325 DDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRL 404
Cdd:COG2319  308 DDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                        330
                 ....*....|....*.
gi 194381934 405 LVSGSSDSTLKVWDVK 420
Cdd:COG2319  387 LASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
99-459 9.19e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 240.20  E-value: 9.19e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  99 RVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGckng 178
Cdd:COG2319   21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA---- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 179 qillweplhanpecryvassSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 257
Cdd:COG2319   97 --------------------SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 258 TLQGHGHWVNTMALSTDyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLVSGSDDFTLFLWSpAED 337
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD---------------------------------------GK---LLASGSDDGTVRLWD-LAT 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 338 KKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 417
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 194381934 418 DVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 459
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
121-460 1.02e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.92  E-value: 1.02e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 121 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGckngqillweplhanpecryvassSK 200
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAG------------------------AG 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 201 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDyalrt 279
Cdd:COG2319   57 DLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD----- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 280 gafepaeasvnpqdlqgslqelkeralsrynlvrGQgpeRLVSGSDDFTLFLWSpAEDKKPLTRMTGHQALINQVLFSPD 359
Cdd:COG2319  132 ----------------------------------GK---TLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPD 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 360 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVD 439
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                        330       340
                 ....*....|....*....|.
gi 194381934 440 WSPDGQRVASGGKDKCLRIWR 460
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-418 9.35e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.16  E-value: 9.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGrklasgckngqillwe 184
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG---------------- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 185 plhanpecRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 263
Cdd:cd00200  148 --------TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 264 HWVNTMAlstdyalrtgafepaeasvnpqdlqgslqelkeralsrynlvrgqgperlvsgsddftlflwspaedkkpltr 343
Cdd:cd00200  220 NGVNSVA------------------------------------------------------------------------- 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194381934 344 mtghqalinqvlFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 418
Cdd:cd00200  227 ------------FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
105-252 3.82e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 3.82e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGckngqillwe 184
Cdd:COG2319  279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG---------- 348

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934 185 plhanpecryvassSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHD 252
Cdd:COG2319  349 --------------SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDLAT 403
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 17-77 9.67e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 68.70  E-value: 9.67e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194381934   17 LLVQFQDEGGQL--LGSPFDVPVDITPDRLQLVCNALLAQED---PLPLAFFVHDAEIVSSLGKTL 77
Cdd:pfam08154   1 VQVRFVTKEGELavPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-142 7.53e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 7.53e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 194381934   105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 379-418 8.23e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 8.23e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194381934   379 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 418
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
105-142 1.59e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.59e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 194381934  105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 317-432 7.10e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 7.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 317 PERLVSGSDDFTLFLWS-PAEDKK-----PLTRMTGHQALINQVLFSPDSR-IVASASFDKSIKLWDGRTGKYLASLRGH 389
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 194381934 390 VAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 432
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-184 1.26e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.26e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194381934   145 TETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWE 184
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
380-418 1.36e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.36e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194381934  380 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 418
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 337-376 4.38e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 4.38e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 194381934   337 DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 376
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 423-459 5.48e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 5.48e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 194381934   423 KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 459
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 300-430 8.75e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 8.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 300 ELKERALSRYNL-VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTghQALINQVLFSPDS-RIVASASFDKSIKLWDG 377
Cdd:PLN00181 570 EMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgRSLAFGSADHKVYYYDL 647

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194381934 378 RTGKY-LASLRGHVAAVYQIAWsADSRLLVSGSSDSTLKVWDvkaqkLAMDLPG 430
Cdd:PLN00181 648 RNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD-----LSMSISG 695
WD40 pfam00400
WD domain, G-beta repeat;
338-376 1.13e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 194381934  338 KKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 376
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-248 1.34e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.34e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 194381934   212 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 248
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
423-459 2.42e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.42e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 194381934  423 KLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 459
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 98-417 2.61e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  98 FRVRAVTRcTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTetphfTCKGHRHWVLSISWSPDGRKLASGCKN 177
Cdd:PLN00181 468 LRVKADLK-QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECES-----IIKDGRDIHYPVVELASRSKLSGICWN 541

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 178 GQILlweplhanpecRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVtclrWGGD------GLLYSASQDRTIKVWRAH 251
Cdd:PLN00181 542 SYIK-----------SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRV----WSIDyssadpTLLASGSDDGSVKLWSIN 606

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 252 DGVlcrtlqghghwvntmalstdyalrtgafepaeasvnpqdlqgSLQELKERAlsryNLVRGQGP----ERLVSGSDDF 327
Cdd:PLN00181 607 QGV------------------------------------------SIGTIKTKA----NICCVQFPsesgRSLAFGSADH 640

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 328 TLFLWSPAEDKKPLTRMTGHQALINQVLFSpDSRIVASASFDKSIKLWD------GRTGKYLASLRGHVAAVYQIAWSAD 401
Cdd:PLN00181 641 KVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGHTNVKNFVGLSVS 719

                        330
                 ....*....|....*.
gi 194381934 402 SRLLVSGSSDSTLKVW 417
Cdd:PLN00181 720 DGYIATGSETNEVFVY 735
PTZ00421 PTZ00421
coronin; Provisional
 346-458 4.60e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.20  E-value: 4.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 346 GHQALINQVLFSP-DSRIVASASFDKSIKLWD-------GRTGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKV 416
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 194381934 417 WDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 458
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
212-248 4.71e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 194381934  212 GRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW 248
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 110-252 1.40e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 110 LEGHSEAVISVAFSPTGK-YLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWEPlha 188
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP--- 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194381934 189 nPECRYVASSSKDGSVR----IWdttAGRCERILTghtqsvtclrwggdgLLYSASQDRTIKVWRAHD 252
Cdd:PTZ00421 198 -RDGTIVSSVEAHASAKsqrcLW---AKRKDLIIT---------------LGCSKSQQRQIMLWDTRK 246
WD40 pfam00400
WD domain, G-beta repeat;
147-184 2.15e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 194381934  147 TPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWE 184
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 110-280 7.44e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.41  E-value: 7.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 110 LEGHSEAVISVAFSPT-GKYLASGSGDTTVRFWDLSTE--------TPHFTCKGHRHWVLSISWSPdgrklasgcKNGQI 180
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNdesvkeikDPQCILKGHKKKISIIDWNP---------MNYYI 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 181 LlweplhanpecryvASSSKDGSVRIWDT-TAGRCERILTghTQSVTCLRWGGDGLLYSAS-QDRTIKVWRAHDGVLCRT 258
Cdd:PTZ00420 141 M--------------CSSGFDSFVNIWDIeNEKRAFQINM--PKKLSSLKWNIKGNLLSGTcVGKHMHIIDPRKQEIASS 204

                        170       180
                 ....*....|....*....|....*....
gi 194381934 259 LQGHGH-------WVNTMALSTDYALRTG 280
Cdd:PTZ00420 205 FHIHDGgkntkniWIDGLGGDDNYILSTG 233
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 350-459 2.21e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 350 LINQVLFSPDSRIVASASFDKSIKLW-------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS-DSTLKVWDVKA 421
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFecesiikDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQVWDVAR 564

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 194381934 422 QKLAMDLPGHADEVYAVDW-SPDGQRVASGGKDKCLRIW 459
Cdd:PLN00181 565 SQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
PTZ00420 PTZ00420
coronin; Provisional
 338-428 2.67e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 338 KKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWDGRTGKY--------LASLRGHVAAVYQIAWSADSRLLVSG 408
Cdd:PTZ00420  64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCS 143

                         90       100
                 ....*....|....*....|.
gi 194381934 409 SS-DSTLKVWDVKAQKLAMDL 428
Cdd:PTZ00420 144 SGfDSFVNIWDIENEKRAFQI 164
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 363-419 4.73e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 4.73e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194381934 363 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDV 419
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSsADPTLLASGSDDGSVKLWSI 605
PTZ00420 PTZ00420
coronin; Provisional
 318-376 1.35e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.35e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194381934 318 ERLVSGSDDFTLFLWS-PAED------KKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD 376
Cdd:PTZ00420  88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 113-448 1.49e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 44.26  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  113 HSEAVISVAFSPTGKYL--ASGSGDTTVRFWDL---------STETPHftckghrHWVLSISWSPDGRKLASGCKNGQIL 181
Cdd:COG4946   103 HPANDRVVGWTPDGKSVlfASNRGSPPSRSNQLytvpvdgglPERLPL-------PPAGDGSFSPDGKKLAYTRIGREFR 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  182 LWEplhanpecRYvaSSSKDGSVRIWDTTAGRCERILTG---HTQSVtclrWGGDGLLYSASQDRTIKVWRahdgvlcrt 258
Cdd:COG4946   176 TWK--------RY--RGGTAGDIWIYDLGTGEFTRLTDFggnDRNPM----WIGDRIYFLSDRDGTFNLYS--------- 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  259 lqghghwvntmalstdYALRTGAFE--------PA-EASVNPQDL---QG------SLQELKERALS-RYNLVRGQGPER 319
Cdd:COG4946   233 ----------------YDPDGKDLRqlthfkdfDVrFPSTDGGRIvyeQGgdlyllDLASGEPRKLNiTLAGDFPQRRPR 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  320 LVSGSDDFT-----------LF------LWSPAEDK--KPLTRMTGHQALinQVLFSPDSRIVASASfDKSiklwdGRTG 380
Cdd:COG4946   297 WVDVSGYLTsfalspdgkrvAFeargevFTVPAEKGptRNLTNTPGVRER--LPAWSPDGKSIAYFS-DAS-----GEYE 368

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934  381 KYLASLRGHVAA----------VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLA-MDLPGHADEVYAVDWSPDGQRVA 448
Cdd:COG4946   369 LYIAPADGSGEPkqltlgdlgrVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRkVDTDGYGDGISDLAWSPDSKWLA 447
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 107-165 5.22e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 5.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934  107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 159-231 1.40e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 1.40e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194381934  159 VLSISWSPDGRKLASGCKNGQIllweplhanpecryvassskdgsvRIWDTTAGRCERILTGHTQSVTCLRWG 231
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTV------------------------RLLDAENGKIVHHFSAGSDLITCLGWG 89
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 337-448 1.67e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 337 DKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLW----DGRTGKYLASLRGHVAAvyqIAWSADSRLLV-SGSS 410
Cdd:COG0823   19 DGGEPRRLTNSPGIDTSPAWSPDgRRIAFTSDRGGGPQIYvvdaDGGEPRRLTFGGGYNAS---PSWSPDGKRLAfVSRS 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 194381934 411 DSTLKVWdvkaqklAMDLPGHA-----DEVYAVDWSPDGQRVA 448
Cdd:COG0823   96 DGRFDIY-------VLDLDGGAprrltDGPGSPSWSPDGRRIV 131
PTZ00420 PTZ00420
coronin; Provisional
 386-459 4.22e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934 386 LRGHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDVKAQKLAMD--------LPGHADEVYAVDWSPDGQRV-ASGGKDKC 455
Cdd:PTZ00420  70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDWNPMNYYImCSSGFDSF 149


                 ....
gi 194381934 456 LRIW 459
Cdd:PTZ00420 150 VNIW 153
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 105-197 4.31e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194381934  105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLS-----------------------TETP-HFTCkGHRHWVL 160
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLrgrssekrsrntqtefprkdhviAETPfHILC-GHDDIIT 193

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 194381934  161 SISWSPDGRKLASGCKNGQILlwepLHANPECRYVAS 197
Cdd:pfam20426 194 CLYVSVELDIVISGSKDGTCI----FHTLREGRYVRS 226
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 114-172 4.42e-03

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 39.18  E-value: 4.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194381934  114 SEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTetphftckGHRHWVLSI-------SWSPDGRKLA 172
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLAT--------GQREKVASFpgmngapAFSPDGSKLA 249
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 367-419 5.86e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.86e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194381934  367 SFdKSIKLWDGRTgkyLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 419
Cdd:pfam20426 105 SF-QVISLNDGRM---VQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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