NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|7228294|emb|CAB77148|]
View 

hypothetical protein [Homo sapiens]

Protein Classification

nucleolar protein 12( domain architecture ID 10561190)

nucleolar protein 12 (NOL12) is a nucleolar protein required for pre-large subunit rRNA processing

Gene Ontology:  GO:0003723|GO:0003697
PubMed:  16430885|11452019

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nop25 pfam09805
Nucleolar protein 12 (25kDa); Members of this family of proteins are part of the yeast nuclear ...
 20-67 3.17e-14

Nucleolar protein 12 (25kDa); Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export.


:

Pssm-ID: 430839 [Multi-domain]  Cd Length: 134  Bit Score: 66.90  E-value: 3.17e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7228294     20 LSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQ----RKLREERHQE 67
Cdd:pfam09805  12 VVFDDDARKEYLTGFHKRKLQRRKKAQEQAEKKAREERieerKELREERKKE 63
 
Name Accession Description Interval E-value
Nop25 pfam09805
Nucleolar protein 12 (25kDa); Members of this family of proteins are part of the yeast nuclear ...
 20-67 3.17e-14

Nucleolar protein 12 (25kDa); Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export.


Pssm-ID: 430839 [Multi-domain]  Cd Length: 134  Bit Score: 66.90  E-value: 3.17e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7228294     20 LSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQ----RKLREERHQE 67
Cdd:pfam09805  12 VVFDDDARKEYLTGFHKRKLQRRKKAQEQAEKKAREERieerKELREERKKE 63
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 24-68 3.94e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 37.88  E-value: 3.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 7228294    24 EEKRREylTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEY 68
Cdd:PRK00409 533 EQKAEE--AEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEA 575
 
Name Accession Description Interval E-value
Nop25 pfam09805
Nucleolar protein 12 (25kDa); Members of this family of proteins are part of the yeast nuclear ...
 20-67 3.17e-14

Nucleolar protein 12 (25kDa); Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export.


Pssm-ID: 430839 [Multi-domain]  Cd Length: 134  Bit Score: 66.90  E-value: 3.17e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7228294     20 LSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQ----RKLREERHQE 67
Cdd:pfam09805  12 VVFDDDARKEYLTGFHKRKLQRRKKAQEQAEKKAREERieerKELREERKKE 63
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 24-68 3.94e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 37.88  E-value: 3.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 7228294    24 EEKRREylTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEY 68
Cdd:PRK00409 533 EQKAEE--AEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEA 575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH