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Conserved domains on  [gi|14270308|emb|CAC39452|]
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immunophilin FKBP-52, partial [Mus musculus]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 10446594)

FKBP-type peptidyl-prolyl cis-trans isomerase acts as a PPIase that accelerates the folding of proteins

CATH:  3.10.50.40
EC:  5.2.1.8
Gene Ontology:  GO:0003755|GO:0000413|GO:0061077
PubMed:  27664121
SCOP:  4001062

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
38-129 4.49e-45

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 151.97  E-value: 4.49e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308    38 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 116
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 14270308   117 IPPNATLVFEVEL 129
Cdd:pfam00254  81 IPPNATLVFEVEL 93
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
270-419 3.61e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.34  E-value: 3.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 270 ERGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 344
Cdd:COG4785  78 ERGVAYDSLGDYDLAIADFDQ--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14270308 345 SNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 419
Cdd:COG4785 138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
38-129 4.49e-45

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 151.97  E-value: 4.49e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308    38 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 116
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 14270308   117 IPPNATLVFEVEL 129
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 30-129 2.58e-42

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 144.94  E-value: 2.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308  30 KVIKrEGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYG 109
Cdd:COG0545   4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                        90       100
                ....*....|....*....|
gi 14270308 110 AAGSPPKIPPNATLVFEVEL 129
Cdd:COG0545  82 ERGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 2-133 4.32e-20

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 89.82  E-value: 4.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308    2 EAAENGAQSAPLPLE-----GVDispKQDEGVLKVIKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDL 76
Cdd:PRK10902 120 DAADNEAKGKKYREKfakekGVK---TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRL 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 14270308   77 GKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSpPKIPPNATLVFEVELFEFK 133
Cdd:PRK10902 196 DG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
270-419 3.61e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.34  E-value: 3.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 270 ERGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 344
Cdd:COG4785  78 ERGVAYDSLGDYDLAIADFDQ--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14270308 345 SNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 419
Cdd:COG4785 138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 241-390 3.22e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 59.33  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   241 EVRLKSFEKAKESWE--MSSARSWSRATYVKerGTAYFKEGKYKQALLQYKKIVSWLEyessfsgeemQKVHALRLashl 318
Cdd:TIGR02917 271 DFQKKNYEDARETLQdaLKSAPEYLPALLLA--GASEYQLGNLEQAYQYLNQILKYAP----------NSHQARRL---- 334

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14270308   319 nLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 390
Cdd:TIGR02917 335 -LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 318-385 1.22e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.93  E-value: 1.22e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14270308 318 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 385
Cdd:cd24142   4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
TPR_1 pfam00515
Tetratricopeptide repeat;
316-347 2.76e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.87  E-value: 2.76e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 14270308   316 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 347
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 317-347 5.35e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.12  E-value: 5.35e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 14270308    317 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 347
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 321-434 5.41e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 45.16  E-value: 5.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308  321 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 400
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 14270308  401 REKKLYANMFERLAEEE-----HKVKAEVAAGDHPTDAE 434
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEE 143
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
38-129 4.49e-45

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 151.97  E-value: 4.49e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308    38 GTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGS-PPK 116
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|...
gi 14270308   117 IPPNATLVFEVEL 129
Cdd:pfam00254  81 IPPNATLVFEVEL 93
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 30-129 2.58e-42

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 144.94  E-value: 2.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308  30 KVIKrEGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYG 109
Cdd:COG0545   4 KVLK-EGTG-AKPKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYG 81

                        90       100
                ....*....|....*....|
gi 14270308 110 AAGSPPKIPPNATLVFEVEL 129
Cdd:COG0545  82 ERGAGGVIPPNSTLVFEVEL 101
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 2-133 4.32e-20

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 89.82  E-value: 4.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308    2 EAAENGAQSAPLPLE-----GVDispKQDEGVLKVIKREGTGtETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDL 76
Cdd:PRK10902 120 DAADNEAKGKKYREKfakekGVK---TTSTGLLYKVEKEGTG-EAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRL 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 14270308   77 GKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSpPKIPPNATLVFEVELFEFK 133
Cdd:PRK10902 196 DG--VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGV-PGIPANSTLVFDVELLDVK 249
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
270-419 3.61e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.34  E-value: 3.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 270 ERGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELD 344
Cdd:COG4785  78 ERGVAYDSLGDYDLAIADFDQ--------------------ALELdpdlaEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14270308 345 SNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHK 419
Cdd:COG4785 138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALALLLEDWATAYLLQGDTE 212
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 42-131 6.94e-17

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 79.07  E-value: 6.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   42 PMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKgeVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSPPKIPPNA 121
Cdd:PRK11570 117 PARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFS 194

                         90
                 ....*....|
gi 14270308  122 TLVFEVELFE 131
Cdd:PRK11570 195 TLVFEVELLE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
271-453 3.48e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.27  E-value: 3.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 271 RGTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRL-----ASHLNLAMCHLKLQAFSAAIESCNKALELDS 345
Cdd:COG0457  48 LGLAYLRLGRYEEALADYEQ--------------------ALELdpddaEALNNLGLALQALGRYEEALEDYDKALELDP 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 346 NNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC---QQRTRRQLAREKKLYANMFERLAEEEHKVKA 422
Cdd:COG0457 108 DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAlekLGRYEEALELLEKLEAAALAALLAAALGEAA 187

                       170       180       190
                ....*....|....*....|....*....|.
gi 14270308 423 EVAAGDHPTDAEMKGERNNVAENQSRVETEA 453
Cdd:COG0457 188 LALAAAEVLLALLLALEQALRKKLAILTLAA 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
271-397 7.67e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 7.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 271 RGTAYFKEGKYKQALLQYKKIVswleyessfsgeEMQKVHAlrlASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 350
Cdd:COG0457  14 LGLAYRRLGRYEEAIEDYEKAL------------ELDPDDA---EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 14270308 351 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 397
Cdd:COG0457  79 LNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 233-395 1.66e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 233 HRTAELRYEVRLKSFEKAKESWEMSSARSWSRATYVKERGTAYFKEGKYKQALLQYKKIvswLEYESSFsgeemqkvhal 312
Cdd:COG3914  80 LLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRA---LALNPDF----------- 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 313 rLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQ 392
Cdd:COG3914 146 -AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224


                ...
gi 14270308 393 QRT 395
Cdd:COG3914 225 RQA 227
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 45-149 2.08e-11

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 61.27  E-value: 2.08e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308  45 GDRVFVHYTGWLLDGTKFDSSLDRkDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGaagsppkiPPNATLV 124
Cdd:COG1047   4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 14270308 125 FEVELFEFKGEDLTEE--------EDG----GIIRRI 149
Cdd:COG1047  75 QTVPREQFPEDEELEVgmqvefqtPDGqevpGTVTEV 111
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 243-415 3.30e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 3.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 243 RLKSFEKAKESWEMSSARSWSRATYVKERGTAYFKEGKYKQALLQYKKIVSwleyessfsgEEMQKVHALRLashlnLAM 322
Cdd:COG2956  54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLE----------LDPDDAEALRL-----LAE 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 323 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTR------ 396
Cdd:COG2956 119 IYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGdyeeai 198

                       170       180
                ....*....|....*....|..
gi 14270308 397 ---RQLAREKKLYANMFERLAE 415
Cdd:COG2956 199 aalERALEQDPDYLPALPRLAE 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 243-448 3.65e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 3.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 243 RLKSFEKAKESWEMSSARSWSRATYVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFsgeemqkvhalrlasHLNLAM 322
Cdd:COG2956  88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA---------------YCELAE 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 323 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 402
Cdd:COG2956 153 LYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEAL 232

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 14270308 403 KKLyanmfERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSR 448
Cdd:COG2956 233 ELL-----RKALELDPSDDLLLALADLLERKEGLEAALALLERQLR 273
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 274-385 8.96e-11

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 58.85  E-value: 8.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 274 AYFKEGKYKQALLQYKKIVSwlEYESSfsgeemqkvhALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK---G 350
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLK--RYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdA 69

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14270308 351 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 385
Cdd:COG1729  70 LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAK 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
316-397 1.16e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 1.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 316 SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRT 395
Cdd:COG0457  10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89


                ..
gi 14270308 396 RR 397
Cdd:COG0457  90 GR 91
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 259-397 1.19e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 1.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 259 ARSWSRATYVKERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCN 338
Cdd:COG3914  72 AALLLLAALLELAALLLQALGRYEEALALYRRAL---------------ALNPDNAEALFNLGNLLLALGRLEEALAALR 136

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 14270308 339 KALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 397
Cdd:COG3914 137 RALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 270-397 1.70e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 1.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 270 ERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 349
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEAL---------------ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 14270308 350 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 397
Cdd:COG2956  78 ALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 317-402 4.21e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 4.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 317 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC-QQRT 395
Cdd:COG4235  20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAaFQQG 99


                ....*..
gi 14270308 396 RRQLARE 402
Cdd:COG4235 100 DYAEAIA 106
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 272-384 5.42e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 5.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 272 GTAYFKEGKYKQALLQYKKivswleyessfsgeemqkvhALRLAS-----HLNLAMCHLKLQAFSAAIESCNKALELDSN 346
Cdd:COG4235  24 GRAYLRLGRYDEALAAYEK--------------------ALRLDPdnadaLLDLAEALLAAGDTEEAEELLERALALDPD 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 14270308 347 NEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAA 384
Cdd:COG4235  84 NPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 271-381 1.43e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.35  E-value: 1.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 271 RGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG 350
Cdd:COG4783  44 LGEILLQLGDLDEAIVLLHEAL---------------ELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                        90       100       110
                ....*....|....*....|....*....|.
gi 14270308 351 LFRRGEAHLAVNDFDLARADFQKVLQLYPSN 381
Cdd:COG4783 109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 241-390 3.22e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 59.33  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   241 EVRLKSFEKAKESWE--MSSARSWSRATYVKerGTAYFKEGKYKQALLQYKKIVSWLEyessfsgeemQKVHALRLashl 318
Cdd:TIGR02917 271 DFQKKNYEDARETLQdaLKSAPEYLPALLLA--GASEYQLGNLEQAYQYLNQILKYAP----------NSHQARRL---- 334

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14270308   319 nLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 390
Cdd:TIGR02917 335 -LASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
274-380 1.29e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.09  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 274 AYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIEsCNKALELDSNNEKGLFR 353
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKAL---------------ELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN 64

                        90       100
                ....*....|....*....|....*..
gi 14270308 354 RGEAHLAVNDFDLARADFQKVLQLYPS 380
Cdd:COG3063  65 LAELLLELGDYDEALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 270-405 1.38e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 1.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 270 ERGTAYFKEGKYKQALLQYKKIVswleyessfsgeemqKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 349
Cdd:COG4783   9 ALAQALLLAGDYDEAEALLEKAL---------------ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14270308 350 GLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKL 405
Cdd:COG4783  74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 311-405 2.23e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.04  E-value: 2.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 311 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 390
Cdd:COG5010  51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAA 130

                        90
                ....*....|....*
gi 14270308 391 CQQRTRRQLAREKKL 405
Cdd:COG5010 131 LLLSLGQDDEAKAAL 145
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 218-379 5.19e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 5.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 218 LAMLLAVWGRRGSRSHRTAELRYEVRLKSFEKAKESWEMSSARSWSRATYVKERGTAYFKEGKYKQALLQYKKIVSWLEY 297
Cdd:COG5010   7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 298 ESSFsgeemqkvhalrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQL 377
Cdd:COG5010  87 NPEL---------------YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151


                ..
gi 14270308 378 YP 379
Cdd:COG5010 152 SP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 235-394 1.20e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 54.22  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   235 TAELRYEVRLKSFEKAKESWEMSSARSWSRATYVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRL 314
Cdd:TIGR00990 283 SNELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDP 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   315 A---SHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVC 391
Cdd:TIGR00990 363 RvtqSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVT 442


                  ...
gi 14270308   392 QQR 394
Cdd:TIGR00990 443 QYK 445
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 332-389 1.55e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 1.55e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14270308 332 AAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLA 389
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA 58
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
317-384 5.03e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.30  E-value: 5.03e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14270308 317 HLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAA 384
Cdd:COG4785  76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 302-434 9.06e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 9.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   302 SGEEMQKVHALrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 381
Cdd:TIGR02917 456 KLEKKQPDNAS---LHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKN 532

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 14270308   382 KAAKTQLAVCQQRTRRqlarekklyanmferlaEEEHKVKAEVAAGDHPTDAE 434
Cdd:TIGR02917 533 LRAILALAGLYLRTGN-----------------EEEAVAWLEKAAELNPQEIE 568
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 311-397 1.18e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 311 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 390
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80


                ....*..
gi 14270308 391 CQQRTRR 397
Cdd:COG4783  81 ALLKAGD 87
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 318-385 1.22e-06

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 49.93  E-value: 1.22e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14270308 318 LNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAK 385
Cdd:cd24142   4 LEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEK 71
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
323-397 2.92e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.55  E-value: 2.92e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14270308 323 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARAdFQKVLQLYPSNKAAKTQLAVCQQRTRR 397
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGD 74
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
272-414 5.90e-06

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 47.57  E-value: 5.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 272 GTAYFKEGKYKQALLQYkkivswleyESSFSGEEMQKVHALrlashLNLAMCHLKLQAFSAAIESCNKALELDSNnekgl 351
Cdd:COG4700  96 ADALLELGRYDEAIELY---------EEALTGIFADDPHIL-----LGLAQALFELGRYAEALETLEKLIAKNPD----- 156

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 352 FRRGEAHL-------AVNDFDLARADFQKVLQLYPsNKAAKTQLAVCQQRTRRQlAREKKLYANMFERLA 414
Cdd:COG4700 157 FKSSDAHLlyaraleALGDLEAAEAELEALARRYS-GPEARYRYAKFLARQGRT-AEAKELLEEILDEAK 224
TPR_1 pfam00515
Tetratricopeptide repeat;
316-347 2.76e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.87  E-value: 2.76e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 14270308   316 SHLNLAMCHLKLQAFSAAIESCNKALELDSNN 347
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 317-347 5.35e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.12  E-value: 5.35e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 14270308    317 HLNLAMCHLKLQAFSAAIESCNKALELDSNN 347
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 321-434 5.41e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 45.16  E-value: 5.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308  321 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNkaaktqlavcqqrtrrqlA 400
Cdd:PLN03088  43 AQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGASLAPGD------------------S 104

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 14270308  401 REKKLYANMFERLAEEE-----HKVKAEVAAGDHPTDAE 434
Cdd:PLN03088 105 RFTKLIKECDEKIAEEEkdlvqPVPSDLPSSVTAPPVEE 143
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 270-406 8.92e-05

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 43.70  E-value: 8.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   270 ERGTAYFKEGKYKQALLQYKKIvswleyESSF-SGEEMQKvhalrlaSHLNLAMCHLKLQAFSAAIESCNKALELDSNNE 348
Cdd:TIGR03302  38 EEAKEALDSGDYTEAIKYFEAL------ESRYpFSPYAEQ-------AQLDLAYAYYKSGDYAEAIAAADRFIRLHPNHP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14270308   349 K---GLFRRGEAHLA-VNDFD-------LARADFQKVLQLYPSNK---AAKTQLAVCqqrtRRQLArEKKLY 406
Cdd:TIGR03302 105 DadyAYYLRGLSNYNqIDRVDrdqtaarEAFEAFQELIRRYPNSEyapDAKKRMDYL----RNRLA-GKELY 171
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 270-401 1.47e-04

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 43.33  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 270 ERGTAYFKEGKYKQALLQYKKIVSWLEYessfsGEEMQKVhalrlasHLNLAMCHLKLQAFSAAIESCNKALELDSNNEK 349
Cdd:COG4105  37 EEAKEALEKGDYEKAIKLFEELEPRYPG-----SPYAEQA-------QLMLAYAYYKQGDYEEAIAAADRFIKLYPNSPN 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14270308 350 ---GLFRRGEAH-LAVNDFDL-------ARADFQKVLQLYP-SNKAAKtqlavCQQR---TRRQLAR 401
Cdd:COG4105 105 adyAYYLRGLSYyEQSPDSDRdqtstrkAIEAFQELINRYPdSEYAED-----AKKRideLRDKLAR 166
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 311-417 2.90e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 2.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 311 ALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAv 390
Cdd:COG2956   5 VAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA- 83

                        90       100       110
                ....*....|....*....|....*....|
gi 14270308 391 cqqrtrrQLAREKKLYA---NMFERLAEEE 417
Cdd:COG2956  84 -------QDYLKAGLLDraeELLEKLLELD 106
TPR_1 pfam00515
Tetratricopeptide repeat;
349-381 3.35e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.79  E-value: 3.35e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 14270308   349 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 381
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 241-403 5.59e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   241 EVRLKSFEKAKESWEMSSARSwSRATYVKeRGTAYFK--EGKYKQALLQYKKIVSwleyessfsgEEMQKVHALRLASHL 318
Cdd:TIGR02917 135 YLGLGQLELAQKSYEQALAID-PRSLYAK-LGLAQLAlaENRFDEARALIDEVLT----------ADPGNVDALLLKGDL 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   319 NLAmchlkLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYP-SNKAAKTQLAVCQQRTRR 397
Cdd:TIGR02917 203 LLS-----LGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPnSPLAHYLKALVDFQKKNY 277


                  ....*.
gi 14270308   398 QLAREK 403
Cdd:TIGR02917 278 EDARET 283
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
321-397 6.78e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 6.78e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14270308 321 AMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 397
Cdd:COG4785  46 LALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGD 122
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 349-379 1.49e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.96  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 14270308   349 KGLFRRGEAHLAVNDFDLARADFQKVLQLYP 379
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
341-397 1.63e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 1.63e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 14270308 341 LELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRR 397
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR 57
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 349-381 1.67e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 14270308    349 KGLFRRGEAHLAVNDFDLARADFQKVLQLYPSN 381
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
243-415 4.93e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 4.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 243 RLKSFEKAKESWEMSSARSWSRATYVKERGTAYFKEGKYKQALLQYKKIvswLEYESSFSgeemqkvhalrlASHLNLAM 322
Cdd:COG0457  88 ALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA---LELDPDDA------------DALYNLGI 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 323 CHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLARE 402
Cdd:COG0457 153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232

                       170
                ....*....|...
gi 14270308 403 KKLYANMFERLAE 415
Cdd:COG0457 233 LRLAALALYQYRA 245
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 272-390 5.43e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 5.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   272 GTAYFKEGKYKQALLQYKKIVSwleyessfSGEEMQKVHALrlashlnLAMCHLKLQAFSAAIESCNKALELDSNNE-KG 350
Cdd:TIGR02917  63 GKIYLALGDYAAAEKELRKALS--------LGYPKNQVLPL-------LARAYLLQGKFQQVLDELPGKTLLDDEGAaEL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 14270308   351 LFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAV 390
Cdd:TIGR02917 128 LALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQ 167
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 274-381 5.67e-03

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 37.91  E-value: 5.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308 274 AYFKEGKYKQALLQYKKIVSwleyesSFSGEEMQKVHALRLAShlnlamCHLKLQAFSAAIESCNKAlelDSNNEKGLF- 352
Cdd:COG2976  99 AAVDAGDLDKAAAQLQWVLD------NAKDPALKALARLRLAR------VLLAQKKYDEALATLDAV---KPEAFAALYa 163

                        90       100       110
                ....*....|....*....|....*....|
gi 14270308 353 -RRGEAHLAVNDFDLARADFQKVLQLYPSN 381
Cdd:COG2976 164 eLRGDILLAQGDKAEARAAYQKALAALPED 193
TPR_12 pfam13424
Tetratricopeptide repeat;
312-380 6.99e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 6.99e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14270308   312 LRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKG--------LFRRGEAHLAVNDFDLARADFQKVLQLYPS 380
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPdhpltattLLNLGRLYLELGRYEEALELLERALALAEK 77
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 265-371 7.04e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 38.81  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14270308   265 ATYVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSgeemqkvhalrlashlNLAMCHLKLQAFSAAIESCNKALELD 344
Cdd:TIGR00990 127 AAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPDPVYYS----------------NRAACHNALGDWEKVVEDTTAALELD 190

                          90       100
                  ....*....|....*....|....*..
gi 14270308   345 SNNEKGLFRRGEAHLAVNDFDLARADF 371
Cdd:TIGR00990 191 PDYSKALNRRANAYDGLGKYADALLDL 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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