unnamed protein product, partial [Karlodinium veneficum]
Protein Classification
glycosyltransferase family protein( domain architecture ID 27718)
glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| Glyco_tranf_GTA_type super family | cl11394 | Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ... |
229-588 | 3.46e-11 | ||||||
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities. The actual alignment was detected with superfamily member cd02537: Pssm-ID: 472172 [Multi-domain] Cd Length: 240 Bit Score: 63.43 E-value: 3.46e-11
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| Name | Accession | Description | Interval | E-value | ||||||
| GT8_Glycogenin | cd02537 | Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Glycogenin ... |
229-588 | 3.46e-11 | ||||||
Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Glycogenin initiates the biosynthesis of glycogen by incorporating glucose residues through a self-glucosylation reaction at a Tyr residue, and then acts as substrate for chain elongation by glycogen synthase and branching enzyme. It contains a conserved DxD motif and an N-terminal beta-alpha-beta Rossmann-like fold that are common to the nucleotide-binding domains of most glycosyltransferases. The DxD motif is essential for coordination of the catalytic divalent cation, most commonly Mn2+. Glycogenin can be classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. It is placed in glycosyltransferase family 8 which includes lipopolysaccharide glucose and galactose transferases and galactinol synthases. Pssm-ID: 133018 [Multi-domain] Cd Length: 240 Bit Score: 63.43 E-value: 3.46e-11
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| Glyco_transf_8 | pfam01501 | Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ... |
320-442 | 1.06e-06 | ||||||
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. Pssm-ID: 279798 [Multi-domain] Cd Length: 252 Bit Score: 50.40 E-value: 1.06e-06
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| RfaJ | COG1442 | Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
321-360 | 2.16e-04 | ||||||
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 43.42 E-value: 2.16e-04
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| Name | Accession | Description | Interval | E-value | ||||||
| GT8_Glycogenin | cd02537 | Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Glycogenin ... |
229-588 | 3.46e-11 | ||||||
Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Glycogenin initiates the biosynthesis of glycogen by incorporating glucose residues through a self-glucosylation reaction at a Tyr residue, and then acts as substrate for chain elongation by glycogen synthase and branching enzyme. It contains a conserved DxD motif and an N-terminal beta-alpha-beta Rossmann-like fold that are common to the nucleotide-binding domains of most glycosyltransferases. The DxD motif is essential for coordination of the catalytic divalent cation, most commonly Mn2+. Glycogenin can be classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. It is placed in glycosyltransferase family 8 which includes lipopolysaccharide glucose and galactose transferases and galactinol synthases. Pssm-ID: 133018 [Multi-domain] Cd Length: 240 Bit Score: 63.43 E-value: 3.46e-11
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| GT8_GNT1 | cd06914 | GNT1 is a fungal enzyme that belongs to the GT 8 family; N-acetylglucosaminyltransferase is a ... |
283-360 | 9.60e-07 | ||||||
GNT1 is a fungal enzyme that belongs to the GT 8 family; N-acetylglucosaminyltransferase is a fungal enzyme that catalyzes the addition of N-acetyl-D-glucosamine to mannotetraose side chains by an alpha 1-2 linkage during the synthesis of mannan. The N-acetyl-D-glucosamine moiety in mannan plays a role in the attachment of mannan to asparagine residues in proteins. The mannotetraose and its N-acetyl-D-glucosamine derivative side chains of mannan are the principle immunochemical determinants on the cell surface. N-acetylglucosaminyltransferase is a member of glycosyltransferase family 8, which are, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed, retaining glycosyltransferases. Pssm-ID: 133064 Cd Length: 278 Bit Score: 50.89 E-value: 9.60e-07
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| Glyco_transf_8 | pfam01501 | Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ... |
320-442 | 1.06e-06 | ||||||
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. Pssm-ID: 279798 [Multi-domain] Cd Length: 252 Bit Score: 50.40 E-value: 1.06e-06
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| GT8_A4GalT_like | cd04194 | A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ... |
322-409 | 1.49e-04 | ||||||
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS. Pssm-ID: 133037 [Multi-domain] Cd Length: 248 Bit Score: 43.74 E-value: 1.49e-04
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| RfaJ | COG1442 | Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ... |
321-360 | 2.16e-04 | ||||||
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 441051 [Multi-domain] Cd Length: 301 Bit Score: 43.42 E-value: 2.16e-04
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| Glyco_transf_8 | cd00505 | Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ... |
253-411 | 2.67e-03 | ||||||
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+. Pssm-ID: 132996 [Multi-domain] Cd Length: 246 Bit Score: 39.73 E-value: 2.67e-03
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