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Conserved domains on  [gi|2259371901|emb|CAH2990318|]
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unnamed protein product [Chilo suppressalis]

Protein Classification

CAP family protein( domain architecture ID 10143546)

CAP (CSP/antigen 5/PR1) family protein similar to human Golgi-associated plant pathogenesis related protein 1 (GAPR1) that forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids

PubMed:  18824526
SCOP:  4001882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 206-339 1.92e-72

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


:

Pssm-ID: 349401  Cd Length: 132  Bit Score: 220.93  E-value: 1.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 206 KFEDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNEYGENIFFAWSSDPnfTVSGKEPVDKWYS 285
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSSYGENLAYFSGSGY--DLTGEEAVDSWYN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901 286 EIKDHKFGREPTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQVYVVANYYPPGNM 339
Cdd:cd05382    79 EIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 11-144 5.48e-62

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


:

Pssm-ID: 349401  Cd Length: 132  Bit Score: 194.36  E-value: 5.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  11 DFENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMSYSLNKQYGESIYCGWSPDPntKIKARDCVDKWYS 90
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSSYGENLAYFSGSGY--DLTGEEAVDSWYN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901  91 EINEFSFGREPEVLTCGHFTQIVWKGTKELGVGSAKSKSGKLYVVANYSAPGNY 144
Cdd:cd05382    79 EIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
 
Name Accession Description Interval E-value
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 206-339 1.92e-72

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 220.93  E-value: 1.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 206 KFEDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNEYGENIFFAWSSDPnfTVSGKEPVDKWYS 285
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSSYGENLAYFSGSGY--DLTGEEAVDSWYN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901 286 EIKDHKFGREPTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQVYVVANYYPPGNM 339
Cdd:cd05382    79 EIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 11-144 5.48e-62

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 194.36  E-value: 5.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  11 DFENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMSYSLNKQYGESIYCGWSPDPntKIKARDCVDKWYS 90
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSSYGENLAYFSGSGY--DLTGEEAVDSWYN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901  91 EINEFSFGREPEVLTCGHFTQIVWKGTKELGVGSAKSKSGKLYVVANYSAPGNY 144
Cdd:cd05382    79 EIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 207-335 7.36e-27

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 103.62  E-value: 7.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  207 FEDECLKAHNYYREKHG-----------VPPLELNKKLNKYAEEWAKTLAkkgsMEH-RDQNEYGENIFFAWSSDPNFTV 274
Cdd:smart00198   2 QQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQCP----FGHsTPRPGYGENLAWWSSSTALPDT 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2259371901  275 SGKEPVDKWYSEIKDHKFGR---EPTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQ---VYVVANYYP 335
Cdd:smart00198  78 YASAAVQLWYDEFQDYGYSSntcKDTNGKIGHYTQVVWAKTYKVGCGVANCPDGTkkkTVVVCNYDP 144
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 212-333 1.66e-25

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 99.20  E-value: 1.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 212 LKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQneYGENIF-FAWSSDPNFTVSGKEP----VDKWYSE 286
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHRSP--YGGNIYaRVVAAGYALGDAGPDSaedaVDGWYDS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2259371901 287 IKDHkfgreptslGTGHFTQVIWEDTKEVGVGIAKSKDGQ-VYVVANY 333
Cdd:pfam00188  79 PGTY---------NCGHRTNLLWPKSTKVGCAVAKCGDGGtYYFVCNY 117
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 17-138 2.64e-22

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 90.34  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  17 LEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDamSYSLNKQYGESIY-----CGWSPDPNTKIKARDCVDKWYSe 91
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNG--SHNHRSPYGGNIYarvvaAGYALGDAGPDSAEDAVDGWYD- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2259371901  92 inefsfgrEPEVLTCGHFTQIVWKGTKELGVGSAKSKSG-KLYVVANY 138
Cdd:pfam00188  78 --------SPGTYNCGHRTNLLWPKSTKVGCAVAKCGDGgTYYFVCNY 117
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 189-333 2.55e-19

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 83.12  E-value: 2.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 189 FASDLVNKLKSTSISGDKFEDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNE----------- 257
Cdd:COG2340     2 LLALLLAAAAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHTGPDGsspfdrlkaag 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 258 -----YGENIffAWSSDpnftvSGKEPVDKWYSEikdhkfgreptslgTGHFTQVIWEDTKEVGVGIAKSKDGQVYVVAN 332
Cdd:COG2340    82 ysyraAGENI--AAGYS-----TAEEAVDGWMNS--------------PGHRANILNPDFTEIGVGVAYGGDGGVYWTQV 140


                  .
gi 2259371901 333 Y 333
Cdd:COG2340   141 F 141
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 11-139 9.50e-18

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 78.97  E-value: 9.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901   11 DFENEALEVHNEYRREHG-----------VPPLILSKDICKISQKWAEELAKKDAMSYslnKQYGESIYCGWSPDPNTKI 79
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQCPFGHSTPR---PGYGENLAWWSSSTALPDT 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2259371901   80 KARDCVDKWYSEINEFSFGREPEVLT---CGHFTQIVWKGTKELGVGSAKSKSG---KLYVVANYS 139
Cdd:smart00198  78 YASAAVQLWYDEFQDYGYSSNTCKDTngkIGHYTQVVWAKTYKVGCGVANCPDGtkkKTVVVCNYD 143
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 9-141 4.81e-16

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 74.26  E-value: 4.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901   9 SSDFENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMS-----------------YSlNKQYGESIYCGW 71
Cdd:COG2340    17 LSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFShtgpdgsspfdrlkaagYS-YRAAGENIAAGY 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  72 SPdpntkikARDCVDKWYSeinefsfgrepevlTCGHFTQIVWKGTKELGVGSAKSKSGKLYVVANYSAP 141
Cdd:COG2340    96 ST-------AEEAVDGWMN--------------SPGHRANILNPDFTEIGVGVAYGGDGGVYWTQVFGRP 144
 
Name Accession Description Interval E-value
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 206-339 1.92e-72

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 220.93  E-value: 1.92e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 206 KFEDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNEYGENIFFAWSSDPnfTVSGKEPVDKWYS 285
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSSYGENLAYFSGSGY--DLTGEEAVDSWYN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901 286 EIKDHKFGREPTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQVYVVANYYPPGNM 339
Cdd:cd05382    79 EIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 11-144 5.48e-62

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 194.36  E-value: 5.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  11 DFENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMSYSLNKQYGESIYCGWSPDPntKIKARDCVDKWYS 90
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSSYGENLAYFSGSGY--DLTGEEAVDSWYN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901  91 EINEFSFGREPEVLTCGHFTQIVWKGTKELGVGSAKSKSGKLYVVANYSAPGNY 144
Cdd:cd05382    79 EIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
CAP_PRY1-like cd05384
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 207-341 2.12e-33

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349403  Cd Length: 129  Bit Score: 120.13  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 207 FEDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDqNEYGENIFFAWSSdpnftvsGKEPVDKWYSE 286
Cdd:cd05384     2 FASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSG-GPYGENLALGYSS-------GAAAVDAWYDE 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2259371901 287 IKDHKFGREPTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQ-VYVVANYYPPGNMIG 341
Cdd:cd05384    74 ISDYDYSNPGFSESTGHFTQLVWKSTTQVGCAYKDCGGAWgLYIVCEYDPAGNVIG 129
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 212-341 4.50e-28

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 106.56  E-value: 4.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 212 LKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHrDQNEYGENIFFAWSSdpnfTVSGKEPVDKWYSEIKDHK 291
Cdd:cd05381     5 LDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVH-SNGPYGENLFWGSGD----NWSPADAVKSWVDEKPYYD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2259371901 292 FG----REPTSlgTGHFTQVIWEDTKEVGVGIAK-SKDGQVYVVANYYPPGNMIG 341
Cdd:cd05381    80 YAsntcVGGKM--CGHYTQVVWRNSTRLGCARVVcDNNGGTFVICNYDPPGNYIG 132
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 207-335 7.36e-27

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 103.62  E-value: 7.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  207 FEDECLKAHNYYREKHG-----------VPPLELNKKLNKYAEEWAKTLAkkgsMEH-RDQNEYGENIFFAWSSDPNFTV 274
Cdd:smart00198   2 QQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQCP----FGHsTPRPGYGENLAWWSSSTALPDT 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2259371901  275 SGKEPVDKWYSEIKDHKFGR---EPTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQ---VYVVANYYP 335
Cdd:smart00198  78 YASAAVQLWYDEFQDYGYSSntcKDTNGKIGHYTQVVWAKTYKVGCGVANCPDGTkkkTVVVCNYDP 144
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 212-333 1.66e-25

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 99.20  E-value: 1.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 212 LKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQneYGENIF-FAWSSDPNFTVSGKEP----VDKWYSE 286
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHRSP--YGGNIYaRVVAAGYALGDAGPDSaedaVDGWYDS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2259371901 287 IKDHkfgreptslGTGHFTQVIWEDTKEVGVGIAKSKDGQ-VYVVANY 333
Cdd:pfam00188  79 PGTY---------NCGHRTNLLWPKSTKVGCAVAKCGDGGtYYFVCNY 117
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 210-333 3.91e-25

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 98.46  E-value: 3.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 210 ECLKAHNYYREKH-----GVPPLELNKKLNKYAEEWAKTLAKKGSMEhRDQNEYGENIFfaWSSDPnftVSGKEPVDKWY 284
Cdd:cd00168     3 EILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDCIFSHSSP-TSRQLAGENIA--ASSYD---MDGVAALQAWH 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2259371901 285 SEIKDHKFGRE--PTSLGTGHFTQVIWEDTKEVGVGIAKSKDGQVYVVANY 333
Cdd:cd00168    77 NEIKNYNFGTAqpGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 209-334 4.08e-23

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 93.67  E-value: 4.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 209 DECLKAHNYYREKH------------GVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNeYGENIFFAWSSDPNFTVSG 276
Cdd:cd05380     2 QEILDAHNELRSKVakgklkglppaaNMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGG-VGQNLASVSSSGKDLKELI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2259371901 277 KEPVDKWYSEIKDHKFGREPTSL---GTGHFTQVIWEDTKEVGVGIAKSKDG---QVYVVANYY 334
Cdd:cd05380    81 EDAVNAWFDELKDYGFGSNPNNNfnsGIGHFTQMVWAKTTKVGCAVARCPKGggnKTYVVCNYS 144
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 17-147 6.04e-23

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 92.70  E-value: 6.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  17 LEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMSYSlNKQYGESIYCGWSPDpntkIKARDCVDKWYSEINEFS 96
Cdd:cd05381     5 LDAHNQARAAVGVPPLVWDDTLAAYAQKYANQRRGDCSLVHS-NGPYGENLFWGSGDN----WSPADAVKSWVDEKPYYD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2259371901  97 FG----REPEVltCGHFTQIVWKGTKELGVGSAK-SKSGKLYVVANYSAPGNYSGQ 147
Cdd:cd05381    80 YAsntcVGGKM--CGHYTQVVWRNSTRLGCARVVcDNNGGTFVICNYDPPGNYIGE 133
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 14-138 7.64e-23

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 92.30  E-value: 7.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  14 NEALEVHNEYRREH-----GVPPLILSKDICKISQKWAEELAKKDAmSYSLNKQYGESIYcgWSPDPntkIKARDCVDKW 88
Cdd:cd00168     2 QEILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDCIFSHS-SPTSRQLAGENIA--ASSYD---MDGVAALQAW 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2259371901  89 YSEINEFSFGREPEVLT--CGHFTQIVWKGTKELGVGSAKSKSGKLYVVANY 138
Cdd:cd00168    76 HNEIKNYNFGTAQPGFNsgTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNY 127
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 17-138 2.64e-22

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 90.34  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  17 LEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDamSYSLNKQYGESIY-----CGWSPDPNTKIKARDCVDKWYSe 91
Cdd:pfam00188   1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNG--SHNHRSPYGGNIYarvvaAGYALGDAGPDSAEDAVDGWYD- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2259371901  92 inefsfgrEPEVLTCGHFTQIVWKGTKELGVGSAKSKSG-KLYVVANY 138
Cdd:pfam00188  78 --------SPGTYNCGHRTNLLWPKSTKVGCAVAKCGDGgTYYFVCNY 117
CAP_PRY1-like cd05384
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 11-146 4.03e-22

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349403  Cd Length: 129  Bit Score: 90.47  E-value: 4.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  11 DFENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELakkdAMSYSL---NKQYGESIYCGWSpdpntkiKARDCVDK 87
Cdd:cd05384     1 SFASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSY----DCSGNLvhsGGPYGENLALGYS-------SGAAAVDA 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2259371901  88 WYSEINEFSF---GREPEVltcGHFTQIVWKGTKELGVGSAKSKSGK-LYVVANYSAPGNYSG 146
Cdd:cd05384    70 WYDEISDYDYsnpGFSEST---GHFTQLVWKSTTQVGCAYKDCGGAWgLYIVCEYDPAGNVIG 129
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 189-333 2.55e-19

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 83.12  E-value: 2.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 189 FASDLVNKLKSTSISGDKFEDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNE----------- 257
Cdd:COG2340     2 LLALLLAAAAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHTGPDGsspfdrlkaag 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 258 -----YGENIffAWSSDpnftvSGKEPVDKWYSEikdhkfgreptslgTGHFTQVIWEDTKEVGVGIAKSKDGQVYVVAN 332
Cdd:COG2340    82 ysyraAGENI--AAGYS-----TAEEAVDGWMNS--------------PGHRANILNPDFTEIGVGVAYGGDGGVYWTQV 140


                  .
gi 2259371901 333 Y 333
Cdd:COG2340   141 F 141
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 11-139 9.50e-18

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 78.97  E-value: 9.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901   11 DFENEALEVHNEYRREHG-----------VPPLILSKDICKISQKWAEELAKKDAMSYslnKQYGESIYCGWSPDPNTKI 79
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaapaasnMLKLTWDCELASSAQNWANQCPFGHSTPR---PGYGENLAWWSSSTALPDT 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2259371901   80 KARDCVDKWYSEINEFSFGREPEVLT---CGHFTQIVWKGTKELGVGSAKSKSG---KLYVVANYS 139
Cdd:smart00198  78 YASAAVQLWYDEFQDYGYSSNTCKDTngkIGHYTQVVWAKTYKVGCGVANCPDGtkkKTVVVCNYD 143
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 14-139 2.11e-17

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 77.88  E-value: 2.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  14 NEALEVHNEYRREH---GVPPLILSKDICKIsqKWAEELAKKdAMSYS-----------LNKQYGESIYCGWSPDPNTKI 79
Cdd:cd05380     2 QEILDAHNELRSKVakgKLKGLPPAANMPKL--KWDCELAKL-AQNWAktcvfahspcrNTGGVGQNLASVSSSGKDLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2259371901  80 KARDCVDKWYSEINEFSFGREPEVLT---CGHFTQIVWKGTKELGVGSAKSKSG---KLYVVANYS 139
Cdd:cd05380    79 LIEDAVNAWFDELKDYGFGSNPNNNFnsgIGHFTQMVWAKTTKVGCAVARCPKGggnKTYVVCNYS 144
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 9-141 4.81e-16

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 74.26  E-value: 4.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901   9 SSDFENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMS-----------------YSlNKQYGESIYCGW 71
Cdd:COG2340    17 LSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFShtgpdgsspfdrlkaagYS-YRAAGENIAAGY 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  72 SPdpntkikARDCVDKWYSeinefsfgrepevlTCGHFTQIVWKGTKELGVGSAKSKSGKLYVVANYSAP 141
Cdd:COG2340    96 ST-------AEEAVDGWMN--------------SPGHRANILNPDFTEIGVGVAYGGDGGVYWTQVFGRP 144
CAP_bacterial cd05379
Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 208-334 2.07e-14

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.


Pssm-ID: 349398  Cd Length: 120  Bit Score: 68.95  E-value: 2.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 208 EDECLKAHNYYREKHGVPPLELNKKLNKYAEEWAKTLAKKGSMEHRDQNEYGENIFFAWSSDPNF-------TVSGKEPV 280
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGSSDRAARAGYWYRGAgeniaygQGSAEEAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901 281 DKWYSEIkdhkfgreptslgtGHFTQVIWEDTKEVGVGIAKSKDGQVYVVANYY 334
Cdd:cd05379    81 NQWINSP--------------GHRANILDPDFTEIGVGVAYNSSGGTYWTQVFG 120
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 215-335 2.08e-14

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 69.30  E-value: 2.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 215 HNYYREKhGVPPLE--LNKKLNKYAEEWAKTLAKKGSMEHRDQNEY-------GENIFFawSSDPnftVSGKEPVDKWYS 285
Cdd:cd05383    10 HNALRRS-VNPPASnmLKMSWNPEAAENAQRWANRCNFTHSPPNGRtipgircGENIFM--SSYP---ASWSEVIQAWYD 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2259371901 286 EIKDHKFGREPTSLG--TGHFTQVIWEDTKEVGVGIAK---SKDGQVYVVANYYP 335
Cdd:cd05383    84 EYKDFKYGVGAKPPGsvTGHYTQVVWYSSYLVGCAVAYcpsQGSLKYFYVCQYCP 138
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 206-337 6.48e-13

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 65.51  E-value: 6.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 206 KFEDECLKAHNYYREKhgVPP-------LELNKKLNKYAEEWAK-------TLAKKGSMEHRDQNEYGENIFFAwsSDPN 271
Cdd:cd05385     1 AFIDECVRIHNELRSK--VSPpaanmryMSWDKALAKTARAWARkckfshnICLKEPGKCHPNFTTLGENIWLG--SIFS 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2259371901 272 FTVsgKEPVDKWYSEIKDHKFGREPTSLGTGHFTQVIWEDTKEVG---------VGIAKSKDGQVYvVANYYPPG 337
Cdd:cd05385    77 FSV--ESAITSWYNEVKDYNFKTNSCSRVCGHYTQVVWADSYKVGcavhvcpngGGFFSGSSSAIF-VCNYGPAG 148
CAP_bacterial cd05379
Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 13-138 3.86e-12

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.


Pssm-ID: 349398  Cd Length: 120  Bit Score: 62.40  E-value: 3.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  13 ENEALEVHNEYRREHGVPPLILSKDICKISQKWAEELAKKDAMSYS--------------LNKQYGESIYCGWSPdpntk 78
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTgpdgssdraaragyWYRGAGENIAYGQGS----- 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  79 ikARDCVDKWYSEInefsfgrepevltcGHFTQIVWKGTKELGVGSAKSKSGKLYVVANY 138
Cdd:cd05379    76 --AEEAVNQWINSP--------------GHRANILDPDFTEIGVGVAYNSSGGTYWTQVF 119
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 212-334 7.16e-09

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 53.58  E-value: 7.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 212 LKAHNYYREKHGVPPLELNK-KLNKYAEEWAKTLAKKGSMEH-RDQNEYGENIFFawSSDPNFTVsgKEPVDKWYSEIKD 289
Cdd:cd05559     5 VDLHNQYRSQVSPSAANMLKmTWDTELEALAKAYARKCIWEHnPDRGRVGENLFA--STGKPLDV--ELAVEDWHNEKEY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2259371901 290 HKFGREPTSLGT--GHFTQVIWEDTKEVGVGIAKSKDGQV-------YVVANYY 334
Cdd:cd05559    81 YNFETKTCAPGKmcGHYTQVVWANTEKIGCGSYFCETLEGvewenatLLVCNYE 134
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 11-142 2.70e-08

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 52.41  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  11 DFENEALEVHNEYRREhgVPP-------LILSKDICKISQKWAEELA-------KKDAMSYSLNKQYGESIYCGWSPDPN 76
Cdd:cd05385     1 AFIDECVRIHNELRSK--VSPpaanmryMSWDKALAKTARAWARKCKfshniclKEPGKCHPNFTTLGENIWLGSIFSFS 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2259371901  77 tkikARDCVDKWYSEINEFSFGREPEVLTCGHFTQIVWKGTKELG--------VGSAKSKSGKLYVVANYSAPG 142
Cdd:cd05385    79 ----VESAITSWYNEVKDYNFKTNSCSRVCGHYTQVVWADSYKVGcavhvcpnGGGFFSGSSSAIFVCNYGPAG 148
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 14-138 4.63e-08

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 51.59  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  14 NEALEVHNEYRREhGVPPlilSKDICKISqkWAEELAKKDA-------MSYSL-NKQYGESIYCG-----------WSpd 74
Cdd:cd05383     4 QEIVDLHNALRRS-VNPP---ASNMLKMS--WNPEAAENAQrwanrcnFTHSPpNGRTIPGIRCGenifmssypasWS-- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  75 pntkikarDCVDKWYSEINEFSFG---REPEVLTcGHFTQIVWKGTKELGVGSAK---SKSGKLYVVANY 138
Cdd:cd05383    76 --------EVIQAWYDEYKDFKYGvgaKPPGSVT-GHYTQVVWYSSYLVGCAVAYcpsQGSLKYFYVCQY 136
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 17-125 2.12e-06

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 46.64  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  17 LEVHNEYRREHGvPPlilSKDICKISqkWAEELAKKdAMSYSLN---------KQYGESIYCGWSPDPNTKikarDCVDK 87
Cdd:cd05559     5 VDLHNQYRSQVS-PS---AANMLKMT--WDTELEAL-AKAYARKciwehnpdrGRVGENLFASTGKPLDVE----LAVED 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2259371901  88 WYSEINEFSFgrepEVLTC------GHFTQIVWKGTKELGVGSA 125
Cdd:cd05559    74 WHNEKEYYNF----ETKTCapgkmcGHYTQVVWANTEKIGCGSY 113
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 208-333 1.02e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 39.20  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 208 EDECLKAHNYYREKhgVPP-------LELNKKLNKYAEEWAKtlakKGSMEHRDQN---EYGENIFFAWSS--DPNFTVS 275
Cdd:cd18816     1 KEEILQLHNKLRGQ--VYPsasnmeyMTWDDELERSAEAWAQ----QCIWEHGPTSllpSIGQNLAVHWGRyrSPAFHVQ 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2259371901 276 GkepvdkWYSEIKDHKF-----------GREPTSLGTgHFTQVIWEDTKEVGVGIAKSK---------DGQVYVVANY 333
Cdd:cd18816    75 S------WYDEVKDYTYpyphecnpwcpERCSGPMCT-HYTQIVWATTNKVGCAVNVCRrmnvwgeiwENAVYLVCNY 145
CAP_CRISPLD1 cd18813
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 232-333 3.68e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349407  Cd Length: 146  Bit Score: 37.29  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901 232 KLNKYAEEWAKTLAkkgsMEHRDQN---EYGENIFFAWSSD--PNFTVSGkepvdkWYSEIKDHKFGREP---------- 296
Cdd:cd18813    30 ELERSAEAWAETCL----WEHGPAHllpSIGQNLGAHWGRYrpPTFHVQA------WYDEVRDFSYPYPQecnpycpfrc 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2259371901 297 TSLGTGHFTQVIWEDTKEVGVGIAKSKD----GQ-----VYVVANY 333
Cdd:cd18813   100 SGPVCTHYTQVVWATSNRIGCAINLCHNmnvwGQiwpkaIYLVCNY 145
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 13-139 4.07e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 37.27  E-value: 4.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2259371901  13 ENEALEVHNEYRREhgVPP-------LILSKDICKISQKWAEELAKKDAMSySLNKQYGESIYCGW----SPDPNtkika 81
Cdd:cd18816     1 KEEILQLHNKLRGQ--VYPsasnmeyMTWDDELERSAEAWAQQCIWEHGPT-SLLPSIGQNLAVHWgryrSPAFH----- 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2259371901  82 rdcVDKWYSEINEFSFGRE-------PEVLT---CGHFTQIVWKGTKELGVGSAKSK---------SGKLYVVANYS 139
Cdd:cd18816    73 ---VQSWYDEVKDYTYPYPhecnpwcPERCSgpmCTHYTQIVWATTNKVGCAVNVCRrmnvwgeiwENAVYLVCNYS 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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