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Conserved domains on  [gi|2558071155|tpg|DBA12190|]
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TPA: IGLV2-33*02, partial [Gorilla gorilla gorilla]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 23-118 3.43e-33

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04984:

Pssm-ID: 472250  Cd Length: 105  Bit Score: 111.40  E-value: 3.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPPFVSGAPGQSVTISCTGTSSDVGDYdHVFWYQKRLSTTSRLLIYNVNTRPSGISDLFSGSKSGNVASLTISGLKSE 102
Cdd:cd04984     2 LTQPSSLSVSPGETVTITCTGSSGNISGN-YVNWYQQKPGSAPRYLIYEDKHRPSGIPDRFSGSKSGNTASLTISGAQTE 80

                          90
                  ....*....|....*..
gi 2558071155 103 VEANYHCSL-YSSSYTF 118
Cdd:cd04984    81 DEADYYCQVwDSNSYVF 97
 
Name Accession Description Interval E-value
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 23-118 3.43e-33

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 111.40  E-value: 3.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPPFVSGAPGQSVTISCTGTSSDVGDYdHVFWYQKRLSTTSRLLIYNVNTRPSGISDLFSGSKSGNVASLTISGLKSE 102
Cdd:cd04984     2 LTQPSSLSVSPGETVTITCTGSSGNISGN-YVNWYQQKPGSAPRYLIYEDKHRPSGIPDRFSGSKSGNTASLTISGAQTE 80

                          90
                  ....*....|....*..
gi 2558071155 103 VEANYHCSL-YSSSYTF 118
Cdd:cd04984    81 DEADYYCQVwDSNSYVF 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-116 3.44e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.85  E-value: 3.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  24 TQPPFVSGAPGQSVTISCTGTSSDVGDYDHVFWYQKRLSTTSRLLI--YNVNTRPSGISDLFSGSKSGNV--ASLTISGL 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIayYSNGSEEGVKKGRFSGRGDPSNgdGSLTIQNL 80

                          90
                  ....*....|....*..
gi 2558071155 100 KSEVEANYHCSLYSSSY 116
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGE 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-117 1.72e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.89  E-value: 1.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155   26 PPFVSGAPGQSVTISCTGTSSDVgdyDHVFWYQKRLsttsRLLIYNVNtrpsgisdlFSGSKSGNVASLTISGLKSEVEA 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP---PEVTWYKQGG----KLLAESGR---------FSVSRSGSTSTLTISNVTPEDSG 64

                           90
                   ....*....|..
gi 2558071155  106 NYHCSLYSSSYT 117
Cdd:smart00410  65 TYTCAATNSSGS 76
 
Name Accession Description Interval E-value
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 23-118 3.43e-33

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 111.40  E-value: 3.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPPFVSGAPGQSVTISCTGTSSDVGDYdHVFWYQKRLSTTSRLLIYNVNTRPSGISDLFSGSKSGNVASLTISGLKSE 102
Cdd:cd04984     2 LTQPSSLSVSPGETVTITCTGSSGNISGN-YVNWYQQKPGSAPRYLIYEDKHRPSGIPDRFSGSKSGNTASLTISGAQTE 80

                          90
                  ....*....|....*..
gi 2558071155 103 VEANYHCSL-YSSSYTF 118
Cdd:cd04984    81 DEADYYCQVwDSNSYVF 97
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 23-118 2.44e-20

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 78.97  E-value: 2.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPP-FVSGAPGQSVTISCTgTSSDVGdYDHVFWYQKRLSTTSRLLIYNVNTRPSGISDLFSGSKSGNVASLTISGLKS 101
Cdd:cd04980     3 MTQSPaSLSVSPGERVTISCK-ASQSIS-SNYLAWYQQKPGQAPKLLIYYASTLHSGVPSRFSGSGSGTDFTLTISSVEP 80

                          90
                  ....*....|....*...
gi 2558071155 102 EVEANYHC-SLYSSSYTF 118
Cdd:cd04980    81 EDAAVYYCqQGYTFPYTF 98
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 23-118 3.70e-16

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 68.51  E-value: 3.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPP-FVSGAPGQSVTISCTGTSSDvgDYDHVFWYQKRLSTTSRLLIY---NVNTRPSGISDLFSGSKSG-NVASLTIS 97
Cdd:cd00099     1 VTQSPrSLSVQEGESVTLSCEVSSSF--SSTYIYWYRQKPGQGPEFLIYlssSKGKTKGGVPGRFSGSRDGtSSFSLTIS 78

                          90       100
                  ....*....|....*....|.
gi 2558071155  98 GLKSEVEANYHCSLYSSSYTF 118
Cdd:cd00099    79 NLQPEDSGTYYCAVSESGGTD 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-116 3.44e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.85  E-value: 3.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  24 TQPPFVSGAPGQSVTISCTGTSSDVGDYDHVFWYQKRLSTTSRLLI--YNVNTRPSGISDLFSGSKSGNV--ASLTISGL 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIayYSNGSEEGVKKGRFSGRGDPSNgdGSLTIQNL 80

                          90
                  ....*....|....*..
gi 2558071155 100 KSEVEANYHCSLYSSSY 116
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGE 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-117 1.72e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.89  E-value: 1.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155   26 PPFVSGAPGQSVTISCTGTSSDVgdyDHVFWYQKRLsttsRLLIYNVNtrpsgisdlFSGSKSGNVASLTISGLKSEVEA 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP---PEVTWYKQGG----KLLAESGR---------FSVSRSGSTSTLTISNVTPEDSG 64

                           90
                   ....*....|..
gi 2558071155  106 NYHCSLYSSSYT 117
Cdd:smart00410  65 TYTCAATNSSGS 76
IGv smart00406
Immunoglobulin V-Type;
36-110 1.87e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155   36 SVTISCTGTSSDVGDYdHVFWYQKRLSTTSRLLIYNVNTRPSGISDLF------SGSKSGNVASLTISGLKSEVEANYHC 109
Cdd:smart00406   1 SVTLSCKFSGSTFSSY-YVSWVRQPPGKGLEWLGYIGSNGSSYYQESYkgrftiSKDTSKNDVSLTISNLRVEDTGTYYC 79


                   .
gi 2558071155  110 S 110
Cdd:smart00406  80 A 80
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 27-117 4.62e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 44.82  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  27 PFVSGAPGQSVTISCTGTSSDvgDYDHVFWYQKRLSTTSRLLIYNVNTRPSGISDLFSGS--KSGNVASLTISGLKSEVE 104
Cdd:cd07706     7 PDVSVQVGEEVTLNCRYETSW--TNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNfqKAQKSISLTISALQLEDS 84

                          90
                  ....*....|...
gi 2558071155 105 ANYHCSLYSSSYT 117
Cdd:cd07706    85 AKYFCALSLPYDT 97
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 23-110 1.06e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 43.81  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQ-PPFVSGAPGQSVTISCTGTSsdvgDYDHVFWYQKRLSTTSRLLIY----NVNTRPSGISDLFSGSK-SGNVASLTI 96
Cdd:cd05899     1 VTQsPRYLIKRRGQSVTLRCSQKS----GHDNMYWYRQDPGKGLQLLFYsyggGLNEEGDLPGDRFSASRpSLTRSSLTI 76

                          90
                  ....*....|....
gi 2558071155  97 SGLKSEVEANYHCS 110
Cdd:cd05899    77 KSAEPEDSAVYLCA 90
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 23-115 1.13e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 38.50  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPP-FVSGAPGQSVTISCTGTSSDVgDYDHVFWY-QKRLSTTSRLLIYNVNTRPSGISDLFSG----SKSGNV--ASL 94
Cdd:cd04982     1 LEQPQlSITREESKSVTISCKVSGIDF-STTYIHWYrQKPGQALERLLYVSSTSAVRKDSGKTKNkfeaRKDVGKstSTL 79

                          90       100
                  ....*....|....*....|.
gi 2558071155  95 TISGLKSEVEANYHCSLYSSS 115
Cdd:cd04982    80 TITNLEKEDSATYYCAYWESG 100
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 24-117 4.06e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 36.86  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  24 TQPP-FVSGAPGQSVTISCTGTSSDvgdYDHVFWYQKRLSTTSRLLIYNVNTRPSGISDLFSGS--KSGNVASLTISGLK 100
Cdd:cd04983     2 TQSPqSLSVQEGENVTLNCNYSTST---FYYLFWYRQYPGQGPQFLIYISSDSGNKKKGRFSATldKSRKSSSLHISAAQ 78

                          90
                  ....*....|....*..
gi 2558071155 101 SEVEANYHCSLYSSSYT 117
Cdd:cd04983    79 LSDSAVYFCALSESGGT 95
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 26-113 7.63e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 36.27  E-value: 7.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  26 PPFVSGAPGQSVTISCTGTSSDVGDYDHVFWYQKRLSTTSRLLIYNvntrPS-GISdlFSGSKSGNV-----------AS 93
Cdd:cd05718     6 PTEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKIGAGSSQNVAVFH----PQyGPS--VPNPYAERVeflaarlglrnAT 79

                          90       100
                  ....*....|....*....|
gi 2558071155  94 LTISGLKSEVEANYHCSLYS 113
Cdd:cd05718    80 LRIRNLRVEDEGNYICEFAT 99
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 23-109 2.32e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 34.68  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558071155  23 LTQPPFVSGAPGQSVTISCtgtssdvgDYD-HVFWYQKRL----STTSRLLIYNVNTRPSGISDLFSGSKSGNVaSLTIS 97
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQC--------PYPpKYASSRKYWckwgSEGCQTLVSSEGVVPGGRISLTDDPDNGVF-TVTLN 71

                          90
                  ....*....|..
gi 2558071155  98 GLKSEVEANYHC 109
Cdd:cd05716    72 QLRKEDAGWYWC 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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