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Conserved domains on  [gi|119581118|gb|EAW60714|]
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keratin associated protein 4-2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-135 5.48e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.51  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118    4 SCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSSC---CRPQCCQSVCCQPTCCSPSCCQTTCCRTTCCRPSC 80
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   81 CVSSCFRPQCCQSVCCQPTCCRPSCGQTTCCRT-----TCYRPSCCVSTCCRPTCSSGSC 135
Cdd:pfam01500  98 SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACCCQCS 157
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-135 5.48e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.51  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118    4 SCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSSC---CRPQCCQSVCCQPTCCSPSCCQTTCCRTTCCRPSC 80
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   81 CVSSCFRPQCCQSVCCQPTCCRPSCGQTTCCRT-----TCYRPSCCVSTCCRPTCSSGSC 135
Cdd:pfam01500  98 SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACCCQCS 157
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-135 5.48e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.51  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118    4 SCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSSC---CRPQCCQSVCCQPTCCSPSCCQTTCCRTTCCRPSC 80
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVS 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   81 CVSSCFRPQCCQSVCCQPTCCRPSCGQTTCCRT-----TCYRPSCCVSTCCRPTCSSGSC 135
Cdd:pfam01500  98 SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
85-129 9.18e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 55.85  E-value: 9.18e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 119581118   85 CFRPQCCQSVCCQPTCCRPSCGQTTCCRTTCYRPSCCVSTCCRPT 129
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
90-130 9.22e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.84  E-value: 9.22e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 119581118   90 CCQSVCCQPTCCRPSCGQTTCCRTTCYRPSCCVSTCCRPTC 130
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
95-136 5.23e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 5.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 119581118   95 CCQPTCCRPSCGQTTCCRTTCYRPSCCVSTCCRPTCSSGSCC 136
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
45-104 2.01e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.38  E-value: 2.01e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   45 CCRPQCCQSVCCQPTCCSPSccqttccrttccrpsCCVSSCFRPQCCQSVCCQPTCCRPS 104
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPS---------------CCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
55-112 2.38e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 2.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 119581118   55 CCQPTCCspsccqttccrttccRPSCCVSSCFRPQCCQSVCCQPTCCRPSCGQTTCCR 112
Cdd:pfam13885   1 CCQPSCC---------------QPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
40-99 4.19e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 4.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   40 CCVSSCCRPQCCQSVCCQPTCCSpsccqttccrttccrPSCCVSSCFRPQCCQSVCCQPT 99
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQ---------------PSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 38-136 8.76e-07

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 45.55  E-value: 8.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   38 PSCCVSSCCRPQCCQSvCC-QPTCCSPSCCQTTCCRTTCCRPSCCVSSCfrPQCCQSVCCQPTCCRPSCGQTTC------ 110
Cdd:pfam01500  12 PTCSTGGTCGSGCCQP-CCcQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCggigyg 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 119581118  111 --------------CRTTCYRPSCCVSTCCRPTCSSGSCC 136
Cdd:pfam01500  89 qegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCC 128
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
20-64 2.85e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.60  E-value: 2.85e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 119581118   20 CCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCSPS 64
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 40-126 5.69e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 43.24  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581118   40 CCVSSCCRPQCCQSVCCQPTCCSPSCcqttccrttcCRPSCCVSSCFRPQCCQSVCCQPTCcrPSCGQTTCCRTTCYRPS 119
Cdd:pfam01500   9 CGFPTCSTGGTCGSGCCQPCCCQSSC----------CRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTS 76


                  ....*..
gi 119581118  120 CCVSTCC 126
Cdd:pfam01500  77 SCQTGCG 83
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 83-136 5.39e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.15  E-value: 5.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 119581118   83 SSCFRPQCCQSVCCQPTCCRPSCGQTTCCRTTCYRPSCCVSTCCRPTCSSGSCC 136
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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