NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119588719|gb|EAW68313|]
View 

hCG1650756, isoform CRA_b [Homo sapiens]

Protein Classification

small VCP/p97-interacting protein( domain architecture ID 11239345)

small VCP/p97-interacting protein is a novel VCP/p97 adaptor whose function is related to the integrity of the endoplasmic reticulum

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SVIP pfam15811
Small VCP/p97-interacting protein; SVIP, small VCP/p97-interacting protein, is a family of ...
 1-73 1.18e-17

Small VCP/p97-interacting protein; SVIP, small VCP/p97-interacting protein, is a family of proteins found in eukaryotes. SVIP was identified by yeast two-hybrid screening to be an interactive partner of VCP/p97. Mammalian VCP/p97 and its yeast counterpart Cdc48p participate in the formation of organelles, including the endoplasmic reticulum (ER), Golgi apparatus, and nuclear envelope. Over-expression of SVIP caused the formation of large vacuoles that seemed to be derived from the ER. The family has two putative coiled-coil regions and contains proteins of approximately 80 amino acids in length.


:

Pssm-ID: 464888 [Multi-domain]  Cd Length: 77  Bit Score: 69.71  E-value: 1.18e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119588719   1 MGLCFPCPGESAPP---TPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPP-EGGLR 73
Cdd:pfam15811  1 MGLCLSCFGGSAEEvvlTPDAEERRQQQAEAAEKRQEEAESRGIKNPESVRRKQKRAEELEKREQEAARSGgGPGLK 77
 
Name Accession Description Interval E-value
SVIP pfam15811
Small VCP/p97-interacting protein; SVIP, small VCP/p97-interacting protein, is a family of ...
 1-73 1.18e-17

Small VCP/p97-interacting protein; SVIP, small VCP/p97-interacting protein, is a family of proteins found in eukaryotes. SVIP was identified by yeast two-hybrid screening to be an interactive partner of VCP/p97. Mammalian VCP/p97 and its yeast counterpart Cdc48p participate in the formation of organelles, including the endoplasmic reticulum (ER), Golgi apparatus, and nuclear envelope. Over-expression of SVIP caused the formation of large vacuoles that seemed to be derived from the ER. The family has two putative coiled-coil regions and contains proteins of approximately 80 amino acids in length.


Pssm-ID: 464888 [Multi-domain]  Cd Length: 77  Bit Score: 69.71  E-value: 1.18e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119588719   1 MGLCFPCPGESAPP---TPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPP-EGGLR 73
Cdd:pfam15811  1 MGLCLSCFGGSAEEvvlTPDAEERRQQQAEAAEKRQEEAESRGIKNPESVRRKQKRAEELEKREQEAARSGgGPGLK 77
 
Name Accession Description Interval E-value
SVIP pfam15811
Small VCP/p97-interacting protein; SVIP, small VCP/p97-interacting protein, is a family of ...
 1-73 1.18e-17

Small VCP/p97-interacting protein; SVIP, small VCP/p97-interacting protein, is a family of proteins found in eukaryotes. SVIP was identified by yeast two-hybrid screening to be an interactive partner of VCP/p97. Mammalian VCP/p97 and its yeast counterpart Cdc48p participate in the formation of organelles, including the endoplasmic reticulum (ER), Golgi apparatus, and nuclear envelope. Over-expression of SVIP caused the formation of large vacuoles that seemed to be derived from the ER. The family has two putative coiled-coil regions and contains proteins of approximately 80 amino acids in length.


Pssm-ID: 464888 [Multi-domain]  Cd Length: 77  Bit Score: 69.71  E-value: 1.18e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119588719   1 MGLCFPCPGESAPP---TPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPP-EGGLR 73
Cdd:pfam15811  1 MGLCLSCFGGSAEEvvlTPDAEERRQQQAEAAEKRQEEAESRGIKNPESVRRKQKRAEELEKREQEAARSGgGPGLK 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH