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Conserved domains on  [gi|148685893|gb|EDL17840|]
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BCL2/adenovirus E1B interacting protein 1, NIP3, isoform CRA_b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BNIP3 super family cl05857
BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa ...
 1-50 1.94e-17

BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.


The actual alignment was detected with superfamily member pfam06553:

Pssm-ID: 461945  Cd Length: 181  Bit Score: 70.56  E-value: 1.94e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 148685893    1 MRNTSVMKKGgIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF 50
Cdd:pfam06553 133 MRKTGVMKKG-LFSAEFLKVLLPSLLLSHLLGLGLGIYIGKRLTTPTSST 181
 
Name Accession Description Interval E-value
BNIP3 pfam06553
BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa ...
 1-50 1.94e-17

BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.


Pssm-ID: 461945  Cd Length: 181  Bit Score: 70.56  E-value: 1.94e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 148685893    1 MRNTSVMKKGgIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF 50
Cdd:pfam06553 133 MRKTGVMKKG-LFSAEFLKVLLPSLLLSHLLGLGLGIYIGKRLTTPTSST 181
 
Name Accession Description Interval E-value
BNIP3 pfam06553
BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa ...
 1-50 1.94e-17

BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.


Pssm-ID: 461945  Cd Length: 181  Bit Score: 70.56  E-value: 1.94e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 148685893    1 MRNTSVMKKGgIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF 50
Cdd:pfam06553 133 MRKTGVMKKG-LFSAEFLKVLLPSLLLSHLLGLGLGIYIGKRLTTPTSST 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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