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Conserved domains on  [gi|148700584|gb|EDL32531|]
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solute carrier family 17 (sodium phosphate), member 2, isoform CRA_c, partial [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 79-364 2.42e-79

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 249.07  E-value: 2.42e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  79 ALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTegpvmdllsnqsrGIKDFSTRAAVYQWSTETQGIIFSSISY 158
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 159 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 238
Cdd:cd17318   68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 239 LTSIAGSGS-----------------------------IGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqsssp 289
Cdd:cd17318  148 LTSIAYSGSqfgtviamplsgflceslgwpsifyifggLGLLWCLLWFFL------------------------------ 197

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148700584 290 rrsvpikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDvstllycgcdnNGCSPALPTIFQCI 364
Cdd:cd17318  198 -----------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKS-----------NGFLSSLPYLAMWI 250
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 79-364 2.42e-79

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 249.07  E-value: 2.42e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  79 ALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTegpvmdllsnqsrGIKDFSTRAAVYQWSTETQGIIFSSISY 158
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 159 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 238
Cdd:cd17318   68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 239 LTSIAGSGS-----------------------------IGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqsssp 289
Cdd:cd17318  148 LTSIAYSGSqfgtviamplsgflceslgwpsifyifggLGLLWCLLWFFL------------------------------ 197

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148700584 290 rrsvpikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDvstllycgcdnNGCSPALPTIFQCI 364
Cdd:cd17318  198 -----------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKS-----------NGFLSSLPYLAMWI 250
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 59-338 3.15e-76

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 243.50  E-value: 3.15e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584   59 MDEKPTTRKGSGFCSLRYALALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTEGPVmdllsnqsrgikdFSTR 138
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  139 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 218
Cdd:TIGR00894  68 NPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  219 AWTGQFTIWAKWAPPLERSKLTSIAGSGS------------------------------IGCVCCVLWFTVIYDDPMHHP 268
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFqlgtfiflpisgwlceswggwpmifyvfgiVGCAWSLLWFVFPADDPSIHP 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  269 CISVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIR 338
Cdd:TIGR00894 228 CISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGK 297
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
142-344 2.44e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.45  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 142 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMAWT 221
Cdd:COG2271   40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL--LLLRFLLGLGEAGFFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 222 GQFTIWAKWAPPLERSKLTSIAGSG-SIGCVCCVLWFTVIyddpMHHpcISVREKEHITSSVAqqsssprrsvpikAMVR 300
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWL----LAA--FGWRAAFLILGLPG-------------LLLA 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 148700584 301 CLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDVSTLL 344
Cdd:COG2271  179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
MFS_1 pfam07690
Major Facilitator Superfamily;
142-331 2.35e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.52  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  142 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMAWT 221
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  222 GQFTIWAKWAPPLERSKLTSIAGSGS-----------------------------IGCVCCVLWFtvIYDDPMHHPCISV 272
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFglgaalgpllggllaslfgwraaflilaiLSLLAAVLLL--LPRPPPESKRPKP 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148700584  273 REKEHItssvaqqssspRRSVPIKAMVRCLPLWaIFMGFFSHFWLCTIIITYLPTYIST 331
Cdd:pfam07690 183 AEEARL-----------SLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEV 229
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 79-364 2.42e-79

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 249.07  E-value: 2.42e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  79 ALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTegpvmdllsnqsrGIKDFSTRAAVYQWSTETQGIIFSSISY 158
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 159 GIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 238
Cdd:cd17318   68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 239 LTSIAGSGS-----------------------------IGCVCCVLWFTViyddpmhhpcisvrekehitssvaqqsssp 289
Cdd:cd17318  148 LTSIAYSGSqfgtviamplsgflceslgwpsifyifggLGLLWCLLWFFL------------------------------ 197

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148700584 290 rrsvpikamvrCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDvstllycgcdnNGCSPALPTIFQCI 364
Cdd:cd17318  198 -----------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKS-----------NGFLSSLPYLAMWI 250
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 59-338 3.15e-76

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 243.50  E-value: 3.15e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584   59 MDEKPTTRKGSGFCSLRYALALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTEGPVmdllsnqsrgikdFSTR 138
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  139 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGM 218
Cdd:TIGR00894  68 NPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  219 AWTGQFTIWAKWAPPLERSKLTSIAGSGS------------------------------IGCVCCVLWFTVIYDDPMHHP 268
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFqlgtfiflpisgwlceswggwpmifyvfgiVGCAWSLLWFVFPADDPSIHP 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  269 CISVREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIR 338
Cdd:TIGR00894 228 CISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGK 297
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 78-348 1.21e-48

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 169.58  E-value: 1.21e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  78 LALIMHFSNFTMITQRVSLSIAIIAMVNSTQHQDPANASTEGPVmdllSNQSRGIKDFSTrAAVYQWSTETQGIIFSSIS 157
Cdd:cd17381    1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPE----HSSSPSVEHNET-GKKYDWDAETQGWILGSFF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 158 YGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERS 237
Cdd:cd17381   76 YGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 238 KLTSIAGSGS----------IGCVCCVL-WFTVIYddpmhhpcisvrekehITSSVAQQSSsprrsvpIKAMVRCLPLWA 306
Cdd:cd17381  156 RLLTISYAGAqlgtvvslplSGLICYYLdWTYVFY----------------IFGAVGLLWF-------FLWIWLVMPLWA 212

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 148700584 307 IFMGFFSHFWLCTIIITYLPTYISTVLHVNIRD---VSTLLYCGC 348
Cdd:cd17381  213 IVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQEngfLSALPYLGC 257
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 93-247 6.38e-27

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 110.12  E-value: 6.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  93 RVSLSIAIIAMVNSTQHQDPANASTEGPVMDllsnqsrgikdfstraavyqWSTETQGIIFSSISYGIILTLIPSGYLAG 172
Cdd:cd17382   15 RCNLGVAIVRMVNNFTDAYGGKVIVHKAEFN--------------------WTPETVGLIESSFFWGYLVTQIPGGFIAA 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148700584 173 IFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSGS 247
Cdd:cd17382   75 KFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGS 149
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 93-333 6.69e-23

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 98.78  E-value: 6.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  93 RVSLSIAIIAMvnstqhqdpanastegpvmdllsnqsrgikdfstrAAVYQWSTETQGIIFSSISYGIILTLIPSGYLAG 172
Cdd:cd17380   15 RVNMPIAIVPM-----------------------------------AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLAD 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 173 IFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSGS-IGCV 251
Cdd:cd17380   60 RFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSyLGTL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 252 CCVLwftviyddpmhhpcisvrekehITSSVAQQS--SSPRRSVPIKAMVRCL-------PLWAIFMGFFSHFWLCTIII 322
Cdd:cd17380  140 LGGL----------------------IGPLLLEYYgwPSVFYFFGLLGLLWALvwliylpPVWAIIVAHFCMNWGFYILL 197

                        250
                 ....*....|.
gi 148700584 323 TYLPTYISTVL 333
Cdd:cd17380  198 SWLPTYFHEVL 208
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
142-344 2.44e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.45  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 142 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMAWT 221
Cdd:COG2271   40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL--LLLRFLLGLGEAGFFP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 222 GQFTIWAKWAPPLERSKLTSIAGSG-SIGCVCCVLWFTVIyddpMHHpcISVREKEHITSSVAqqsssprrsvpikAMVR 300
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGgPLGGALAPPLLGWL----LAA--FGWRAAFLILGLPG-------------LLLA 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 148700584 301 CLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDVSTLL 344
Cdd:COG2271  179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 139-334 1.48e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 71.30  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 139 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILviVIRTVQGMAQGM 218
Cdd:cd06174   23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL--LGRFLLGLGSGL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 219 AWTGQFTIWAKWAPPLERSKLTSIAGSGS---------------------------IGCVCCVLWFTVIYddpmhhpcIS 271
Cdd:cd06174  101 IDPAVLALIADLFPERERGRALGLLQAFGsvggilgpllggilasslgfgwravflIAAALALLAAILLL--------LV 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148700584 272 VREKEHITSSVAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLH 334
Cdd:cd06174  173 VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
MFS_1 pfam07690
Major Facilitator Superfamily;
142-331 2.35e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.52  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  142 YQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMAWT 221
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  222 GQFTIWAKWAPPLERSKLTSIAGSGS-----------------------------IGCVCCVLWFtvIYDDPMHHPCISV 272
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFglgaalgpllggllaslfgwraaflilaiLSLLAAVLLL--LPRPPPESKRPKP 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148700584  273 REKEHItssvaqqssspRRSVPIKAMVRCLPLWaIFMGFFSHFWLCTIIITYLPTYIST 331
Cdd:pfam07690 183 AEEARL-----------SLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEV 229
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
139-344 2.37e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 2.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 139 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGM 218
Cdd:COG2814   37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLL--LAARFLQGLGAGA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 219 AWTGQFTIWAKWAPPLERSKLTSIAGSGS-------------------------IGCVCCVLWFTVIYddpmhhpcISVR 273
Cdd:COG2814  115 LFPAALALIADLVPPERRGRALGLLGAGLglgpalgpllgglladlfgwrwvflVNAVLALLALLLLL--------RLLP 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148700584 274 EkehitssvAQQSSSPRRSVPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDVSTLL 344
Cdd:COG2814  187 E--------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 150-344 2.58e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.44  E-value: 2.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 150 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRTVQGMAQGMAWTGQFTIWAK 229
Cdd:cd17325   34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQL--LLARFLQGLASAAVWPAAMALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 230 WAPPLERSKLTSIAGSG-SIGCVCCVLWFTVIYDDPMHH---------------PCISVREkEHITSSVAQQSSSPRRSV 293
Cdd:cd17325  112 IAPPEERGRAMGIFSSAiGLGFLIGPLLGGLLADALGYRapflvcaalallalvLALLLLP-EPRPPPNKRAVSAARLRS 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148700584 294 PIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDVSTLL 344
Cdd:cd17325  191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 143-247 2.87e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 61.05  E-value: 2.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 143 QWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQGMAQGMAWTG 222
Cdd:cd17319   34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPG 111

                         90       100
                 ....*....|....*....|....*
gi 148700584 223 QFTIWAKWAPPLERSKLTSIAGSGS 247
Cdd:cd17319  112 AIKALAEWFPARERGRATGLFNSGA 136
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 133-247 3.35e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 60.60  E-value: 3.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 133 KDFSTRAAVYQWstetqgiIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAadFGVILVIVIRTVQ 212
Cdd:COG0477   42 ADLGASSAQLGW-------IVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQ 112

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 148700584 213 GMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSGS 247
Cdd:COG0477  113 GIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
139-344 1.44e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.96  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 139 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILviVIRTVQGMAQGM 218
Cdd:COG2223   32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLL--LLGLLLGIGGGG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 219 AWTGQFTIWAKWAPPLERSKLTSI-AGSGSIG----------------------------CVCCVLWFTVIYDDPMHhpc 269
Cdd:COG2223  110 SFAVGIALVSKWFPPDRRGLALGLaAGGGNLGaavaaflaplliaafgwrnaflilgillLVVAVLAWLFLRDPPAG--- 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148700584 270 isvrekehitssVAQQSSSPRRSvpIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHVNIRDVSTLL 344
Cdd:COG2223  187 ------------AAAAAKASLRD--QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLA 247
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 150-335 2.41e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 52.38  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  150 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFtpLAADFGVILVIVIRTVQGMAQGMAWTGQFTIWAK 229
Cdd:TIGR00881  33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  230 WAPPLERSKLTSI------------------------------AGSGSIGCVCCVLWFTVIYDDPMHHPCISVREKEHIT 279
Cdd:TIGR00881 111 WFSRSERGTWVSFwncshnvgggllpplvlfgiaelyswhwvfIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148700584  280 SSVAQQSSSPRRS---VPIKAMVRCLPLWAIFMGFFSHFWLCTIIITYLPTYISTVLHV 335
Cdd:TIGR00881 191 PDGDAEKKEEELTkkqIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGF 249
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 139-344 1.31e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.93  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 139 AAVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGM 218
Cdd:cd17475   23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF--LVGAGYGS 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 219 AWTGQFTIWAKWAPPLERSKLTSI-------------------------------AGSGSIGC-VCCVLWftviYDDPMh 266
Cdd:cd17475  101 VQPGGGRAIMRWFPPRERGLAMGIrqtgvplggalaaallpplalhygwraafvvAGLVSILAaVLFWLF----YREPP- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 267 hpcisvrekehITSSVAQQSSSPRRSvpIKAMVRCLPLWAIfmgFFSHFWLCTI---IITYLPTYISTVLHVNIRDVSTL 343
Cdd:cd17475  176 -----------AASAATESASTLLRS--LKEVLRNRDVWLI---AIAGALLVAPqfaLLTFLLLFLHDHLGLSVVAAGAL 239


                 .
gi 148700584 344 L 344
Cdd:cd17475  240 L 240
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
140-245 1.34e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.97  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 140 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMA 219
Cdd:COG2814  236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF--LLGFGFGLL 313

                         90       100
                 ....*....|....*....|....*.
gi 148700584 220 WTGQFTIWAKWAPPLERSKLTSIAGS 245
Cdd:COG2814  314 FPLLQALVAELAPPEARGRASGLYNS 339
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 142-242 4.01e-06

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 48.39  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 142 YQWSTETQGIIFS--SISYGIILTLipSGYLAGIFGAKQILGAGLLISSLLTLF--TPLAADFGVILVIVIRTVQGMAQG 217
Cdd:cd17345   33 YGLSKTEIGLIGSalSIAYGLSKFV--MGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQG 110

                         90       100
                 ....*....|....*....|....*
gi 148700584 218 MAWTGQFTIWAKWAPPLERSKLTSI 242
Cdd:cd17345  111 MGWPPSGRTMVHWFSKKERGTWTSI 135
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 141-249 5.92e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 5.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 141 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMAW 220
Cdd:cd17325  229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA--LLGLGLGLVF 306

                         90       100       110
                 ....*....|....*....|....*....|
gi 148700584 221 TGQFTIWAKWAPPLERSKLTSIAGS-GSIG 249
Cdd:cd17325  307 PATLALLADIVPPEGRGTAMGLFNTaFSLG 336
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 145-345 6.06e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 145 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIviRTVQGMAQGMAWTGQF 224
Cdd:cd17324   32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--RALAGLAHGGFWAIAA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 225 TIWAKWAPPLERSKLTSIAGSG-SIG-----------------------------CVCCVLWFTVIYDDPMHHPcisvre 274
Cdd:cd17324  110 AYAADLVPPEKRGRAIGLVFSGlTLGlvlgrplggllgqllgwraaflaiavlalLAALLLWRLLPSLPPKKPG------ 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148700584 275 kehITSSVAQQSSSPRRSVPIKAMVrclplwAIFMGFFSHFwlctIIITYLPTYISTVLHVNIRDVSTLLY 345
Cdd:cd17324  184 ---SLGLLSSLLLLLRNPRLRLAYL------ITFLLFGGFF----ALYTYLAPFLTDVPGFSSSAIIGLLL 241
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 150-244 2.43e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.05  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 150 GIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAAdfGVILVIVIRTVQGMAQGMAWTGQFTIWAK 229
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111

                         90
                 ....*....|....*
gi 148700584 230 WAPPLERSKLTSIAG 244
Cdd:cd17489  112 IIPPSRRGEGIGYYG 126
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 141-221 1.57e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.32  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 141 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSL-LTLFTPLAADFGVILVIVIRTVQGMAQGMA 219
Cdd:cd17321  198 VLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgLLLLALLGADSSVWLLLPGLVLLGLGLGLF 277


                 ..
gi 148700584 220 WT 221
Cdd:cd17321  278 AT 279
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
140-251 1.61e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.30  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 140 AVYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMA 219
Cdd:COG0738   36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALF--LLGLGLGLL 113

                         90       100       110
                 ....*....|....*....|....*....|..
gi 148700584 220 WTGQFTIWAKWAPPLERSKLTSIAGSGSIGCV 251
Cdd:COG0738  114 DVAANPYVAALGPETAASRLNLLHAFFSLGAL 145
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 145-262 2.91e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 2.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 145 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMAWTGQF 224
Cdd:cd17316   34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 148700584 225 TIWAKWAPPLERSKLTSI-AGSGSIGCVCCVLWFTVIYD 262
Cdd:cd17316  112 TYVAEFAPSKRRGFALGLlQSGWALGALLAALVASLLIP 150
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 133-248 7.99e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.41  E-value: 7.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 133 KDFSTRAAVYQWSTetqgiifssISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVIlvIVIRT 210
Cdd:cd17503   24 GDLGASLDTVQWVI---------TSYLLALaIMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--IIFRI 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 148700584 211 VQGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAGSGSI 248
Cdd:cd17503   93 LQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVIL 130
MFS_1 pfam07690
Major Facilitator Superfamily;
141-251 1.12e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  141 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTL-FTPLAADFGVILVIVIRTVQGMAQGMA 219
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLV 308

                          90       100       110
                  ....*....|....*....|....*....|...
gi 148700584  220 WTGQFTIWAKWAPPLERSKLTSIAGS-GSIGCV 251
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTaGSLGGA 341
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 140-272 1.96e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.87  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 140 AVYQWSTETQGIIFSSISYGIILTLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGM 218
Cdd:cd17330  203 DRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAA--ILAFGTGI 280

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148700584 219 AWTGQFTIWAKWAPPLERSK-LTSIAGSGSIGCVCCVLWFTVIYDDPMHHPCISV 272
Cdd:cd17330  281 VFPALSALLSKSVPSKEQGKaQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 141-245 2.02e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584 141 VYQWSTETQGIIFSSISYGIILTLIPSGYLAGI-FGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIrtVQGMAQGMA 219
Cdd:cd17474  228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIV--LFGLGLGLN 305

                         90       100
                 ....*....|....*....|....*.
gi 148700584 220 WTGQFTIWAKWAPPLERSKLTSIAGS 245
Cdd:cd17474  306 LPLLTTLVTELAPEEERGTASSLYNF 331
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 145-246 4.93e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  145 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTVQGMAQGMAWTGQF 224
Cdd:TIGR00895  50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV--TQLLILRFLAGLGLGGLMPNLN 127

                          90       100
                  ....*....|....*....|..
gi 148700584  225 TIWAKWAPPLERSKLTSIAGSG 246
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCG 149
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 134-244 7.98e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 38.13  E-value: 7.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700584  134 DFSTRAAVYQWSTetqgiifssISYGIIL-TLIP-SGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFgvILVIVIRTV 211
Cdd:TIGR00711  31 DLGSSLSQVQWVI---------TSYMLANaISIPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL--ELMIIFRVI 99

                          90       100       110
                  ....*....|....*....|....*....|...
gi 148700584  212 QGMAQGMAWTGQFTIWAKWAPPLERSKLTSIAG 244
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWG 132
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
145-221 9.82e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 37.96  E-value: 9.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148700584 145 STETQGIIFSSISYGIILTLIPSGYLAGIFGAKQILGAGLLISSLLTLFTPLAADFGVILVIVIRTVQGMAQGMAWT 221
Cdd:COG2211  262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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