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Conserved domains on  [gi|148708804|gb|EDL40751|]
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ankyrin repeat and SOCS box-containing protein 9 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-234 3.01e-33

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 3.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  32 DWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666   54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 112 DCVNLLLQHGATPH-PETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN 190
Cdd:COG0666  134 EIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 148708804 191 -QGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDL 234
Cdd:COG0666  214 aKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 249-290 4.32e-15

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 67.89  E-value: 4.32e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLHL 290
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-234 3.01e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 3.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  32 DWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666   54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 112 DCVNLLLQHGATPH-PETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN 190
Cdd:COG0666  134 EIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 148708804 191 -QGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDL 234
Cdd:COG0666  214 aKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-122 1.21e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804   36 LHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHgAQVNGMTIDWrTPLFNACVSGSQDCVN 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78


                  ....*..
gi 148708804  116 LLLQHGA 122
Cdd:pfam12796  79 LLLEKGA 85
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 249-290 4.32e-15

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 67.89  E-value: 4.32e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLHL 290
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-238 2.13e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.09  E-value: 2.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  34 SPLHDAAIHGCLLTL-RNLISQGWPVNIITADHVSPLHEACLRGH-LSCASVLLSHGAQVNGMTIDWRTPLFNA-CVSGS 110
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQAsTLDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 111 QDCVNLLLQHGATPHPETEL-ASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVA-CKNQQVACAKKLLESGVS 188
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148708804 189 VN-QGKGLDSPLHVVARMS-SVELVHLLMDFGANAQAKNADGKRPVdLVPLE 238
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL-LIALE 485
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 250-288 3.77e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.09  E-value: 3.77e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148708804  250 GPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLL 288
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 253-289 6.19e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.01  E-value: 6.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148708804   253 SLRQLCRLRIRKCFGirqhhKISELLLPEDLKRFLLH 289
Cdd:smart00969   2 SLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 3.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.02e-03
                           10        20
                   ....*....|....*....|....*....
gi 148708804    64 DHVSPLHEACLRGHLSCASVLLSHGAQVN 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-234 3.01e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 3.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  32 DWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666   54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 112 DCVNLLLQHGATPH-PETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN 190
Cdd:COG0666  134 EIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 148708804 191 -QGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDL 234
Cdd:COG0666  214 aKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-230 9.60e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 9.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  32 DWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQ 111
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 112 DCVNLLLQHGATP-HPETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN 190
Cdd:COG0666  167 EIVKLLLEAGADVnARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148708804 191 -QGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKR 230
Cdd:COG0666  247 aKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-234 1.09e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.20  E-value: 1.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  31 SDWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGS 110
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 111 QDCVNLLLQHGATPH-PETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSV 189
Cdd:COG0666  100 LEIVKLLLEAGADVNaRDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 148708804 190 N-QGKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDL 234
Cdd:COG0666  180 NaRDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-186 1.79e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.04  E-value: 1.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  31 SDWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGS 110
Cdd:COG0666  119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH 198

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148708804 111 QDCVNLLLQHGATPHPETEL-ASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESG 186
Cdd:COG0666  199 LEIVKLLLEAGADVNAKDNDgKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-167 7.62e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.84  E-value: 7.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  33 WSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQD 112
Cdd:COG0666  154 NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148708804 113 CVNLLLQHGATP-HPETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPL 167
Cdd:COG0666  234 IVKLLLEAGADLnAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-122 1.21e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804   36 LHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHgAQVNGMTIDWrTPLFNACVSGSQDCVN 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78


                  ....*..
gi 148708804  116 LLLQHGA 122
Cdd:pfam12796  79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-159 1.68e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804   69 LHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHgATPHPETELASPIHEAAKRGYVKCIES 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|.
gi 148708804  149 LAAHGANIDYN 159
Cdd:pfam12796  80 LLEKGADINVK 90
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 249-290 4.32e-15

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 67.89  E-value: 4.32e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLHL 290
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-238 2.13e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.09  E-value: 2.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  34 SPLHDAAIHGCLLTL-RNLISQGWPVNIITADHVSPLHEACLRGH-LSCASVLLSHGAQVNGMTIDWRTPLFNA-CVSGS 110
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQAsTLDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 111 QDCVNLLLQHGATPHPETEL-ASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVA-CKNQQVACAKKLLESGVS 188
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148708804 189 VN-QGKGLDSPLHVVARMS-SVELVHLLMDFGANAQAKNADGKRPVdLVPLE 238
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL-LIALE 485
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 18-214 4.78e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 69.13  E-value: 4.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  18 LPFLSNPLMGDVVSDWSPLHDAAIHGCLLtLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTID 97
Cdd:PLN03192 512 LLGDNGGEHDDPNMASNLLTVASTGNAAL-LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  98 WRTPLFNACVSGSQDCVNLLLQ--HGATPHPETELaspIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQ 175
Cdd:PLN03192 591 GNTALWNAISAKHHKIFRILYHfaSISDPHAAGDL---LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDH 667

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 148708804 176 VACAKKLLESGVSVNQGKGLDSplhvvarMSSVELVHLL 214
Cdd:PLN03192 668 VDMVRLLIMNGADVDKANTDDD-------FSPTELRELL 699
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 249-289 5.63e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 62.13  E-value: 5.63e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLY 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-221 6.52e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.48  E-value: 6.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  33 WSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTI-DWRTPLFNACVSGSQ 111
Cdd:PHA02875  36 ISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 112 DCVNLLLQHGATPH-PETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN 190
Cdd:PHA02875 116 DIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195

                        170       180       190
                 ....*....|....*....|....*....|...
gi 148708804 191 Q-GKGLDSPLHVVA-RMSSVELVHLLMDFGANA 221
Cdd:PHA02875 196 YfGKNGCVAALCYAiENNKIDIVRLFIKRGADC 228
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 48-232 1.38e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  48 LRNLI-SQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGAtphp 126
Cdd:PHA02874  17 IEKIIkNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGV---- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 127 ETELAsPIHEAAKrgyvKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN-QGKGLDSPLHVVARM 205
Cdd:PHA02874  93 DTSIL-PIPCIEK----DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNGCYPIHIAIKH 167

                        170       180
                 ....*....|....*....|....*..
gi 148708804 206 SSVELVHLLMDFGANAQAKNADGKRPV 232
Cdd:PHA02874 168 NFFDIIKLLLEKGAYANVKDNNGESPL 194
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-225 1.92e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  134 IHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVNQGKGlDSPLHVVARMSSVELVHL 213
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG-RTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 148708804  214 LMDFGANAQAKN 225
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 251-289 5.40e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.41  E-value: 5.40e-12
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLY 40
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 65-232 8.02e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.01  E-value: 8.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  65 HVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATP---HPETElaSPIHEAAKRG 141
Cdd:PHA02875   2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPdvkYPDIE--SELHDAVEEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 142 YVKCIESLAAHGANIDYNISHLG-TPLYVACKNQQVACAKKLLESGVSVN-QGKGLDSPLHVVARMSSVELVHLLMDFGA 219
Cdd:PHA02875  80 DVKAVEELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                        170
                 ....*....|...
gi 148708804 220 NAQAKNADGKRPV 232
Cdd:PHA02875 160 CLDIEDCCGCTPL 172
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-233 1.33e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  47 TLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPH- 125
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANv 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 126 PETELASPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACakKLLESGVSVN-QGKGLDSPLH-VVA 203
Cdd:PHA02874 186 KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASINdQDIDGSTPLHhAIN 263

                        170       180       190
                 ....*....|....*....|....*....|
gi 148708804 204 RMSSVELVHLLMDFGANAQAKNADGKRPVD 233
Cdd:PHA02874 264 PPCDIDIIDILLYHKADISIKDNKGENPID 293
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 51-232 1.03e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  51 LISQGWPVNIITADHVSPLHEACLRGH-----LSCASVLLSHGAQVNGMTIDWRTPLFNACV--SGSQDCVNLLLQHGAT 123
Cdd:PHA03100  54 LLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGAN 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 124 PHPET-ELASPIHEAAKRGYV--KCIESLAAHGANIDynishlgtplyVACKnqqvacAKKLLESGVSVN--QGKGlDSP 198
Cdd:PHA03100 134 VNIKNsDGENLLHLYLESNKIdlKILKLLIDKGVDIN-----------AKNR------VNYLLSYGVPINikDVYG-FTP 195

                        170       180       190
                 ....*....|....*....|....*....|....
gi 148708804 199 LHVVARMSSVELVHLLMDFGANAQAKNADGKRPV 232
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 250-288 3.77e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.09  E-value: 3.77e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148708804  250 GPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLL 288
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 48-244 4.25e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 4.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  48 LRNLISQGWPVNIITADHV-SPLHEACLRGHLSCASVLLSHGAQVNGMTIdwrtplfnacvsgsqdCVNlllqhgatphp 126
Cdd:PHA02878 150 TKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDK----------------TNN----------- 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 127 etelaSPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVA---CKNQQVacAKKLLESGVSVNQG---KGLdSPLH 200
Cdd:PHA02878 203 -----SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvgyCKDYDI--LKLLLEHGVDVNAKsyiLGL-TALH 274

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 148708804 201 VVARmsSVELVHLLMDFGANAQAKNADGKRPVDLVPLESPLIQI 244
Cdd:PHA02878 275 SSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLCINI 316
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 64-235 7.82e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.23  E-value: 7.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  64 DHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPHPET-ELASPIHEAAKRGY 142
Cdd:PHA02876 144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIAlDDLSVLECAVDSKN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 143 VKCIESLAAHGANIDYNishlGTPLYVACKNQQVACAKKLLESGVSVNQGKGL-DSPLHVVARMSSV-ELVHLLMDFGAN 220
Cdd:PHA02876 224 IDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCkNTPLHHASQAPSLsRLVPKLLERGAD 299

                        170
                 ....*....|....*
gi 148708804 221 AQAKNADGKRPVDLV 235
Cdd:PHA02876 300 VNAKNIKGETPLYLM 314
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-163 8.72e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.83  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  34 SPLHDAAIH--GCLLTLRNLISQGWPVNIITADHVSPLHEA--CLRGHLSCASVLLSHGAQVNGMT-----------IDW 98
Cdd:PHA03100 108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDINAKNrvnyllsygvpINI 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148708804  99 R-----TPLFNACVSGSQDCVNLLLQHGATPHPETELA-SPIHEAAKRGYVKCIESLAAHGANIDYNISHL 163
Cdd:PHA03100 188 KdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-223 1.25e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  34 SPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLH-----------------------------EACLRGHLSCASVL 84
Cdd:PHA02876 180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLEcavdsknidtikaiidnrsninkndlsllKAIRNEDLETSLLL 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  85 LSHGAQVNGMTIDWRTPLFNACVSGS-QDCVNLLLQHGATPHPET-ELASPIHEAAKRGY-VKCIESLAAHGANIDYNIS 161
Cdd:PHA02876 260 YDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNiKGETPLYLMAKNGYdTENIRTLIMLGADVNAADR 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148708804 162 HLGTPLYVAC---KNQQVACAkkLLESGVSVNQGKGLD-SPLHVVARMSSVELVHLLMDFGANAQA 223
Cdd:PHA02876 340 LYITPLHQAStldRNKDIVIT--LLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEA 403
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 35-232 1.60e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  35 PLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNgmtidwrtpLFNACVSGSQDCV 114
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCS---------VFYTLVAIKDAFN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 115 N-------LLLqhgaTPHPETELASPIHEAAKRGYVKCIES-----LAAHGANIDYNISHLG-TPLYVACKNQQVACAKK 181
Cdd:PHA02878 111 NrnveifkIIL----TNRYKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRHKGnTALHYATENKDQRLTEL 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148708804 182 LLESGVSVNQ-GKGLDSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPV 232
Cdd:PHA02878 187 LLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-85 1.61e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.61e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 148708804   33 WSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLL 85
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 99-234 5.54e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 5.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  99 RTPLFNACVSGSQDCVNLLLQHGATPHPETELA-SPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVA 177
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 178 CAKKLLESGVSVNQ---GKGLdSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDL 234
Cdd:PHA02875  83 AVEELLDLGKFADDvfyKDGM-TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHL 141
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 49-125 1.70e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 1.70e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148708804  49 RNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPH 125
Cdd:PTZ00322  99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHF 175
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-118 4.64e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 4.64e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148708804   65 HVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLL 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 251-287 6.06e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 45.25  E-value: 6.06e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFL 287
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
33-92 1.64e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 1.64e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804   33 WSPLHDAAIHGCLLTLRNLISQgWPVNIITaDHVSPLHEACLRGHLSCASVLLSHGAQVN 92
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADIN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 36-231 3.55e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.04  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  36 LHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVN 115
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 116 LLLQHGATPHPETELA-SPIHEAAKrgYVKCIESLAAHGANIDYNISHLGTPLYVACknqQVACAKKLLE------SGVS 188
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGfTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAI---NPPCDIDIIDillyhkADIS 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 148708804 189 VNQGKG---LDSPLHVVARMSsvelvhLLMDFGANAQAKNADGKRP 231
Cdd:PHA02874 283 IKDNKGenpIDTAFKYINKDP------VIKDIIANAVLIKEADKLK 322
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 253-289 6.19e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.01  E-value: 6.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148708804   253 SLRQLCRLRIRKCFGirqhhKISELLLPEDLKRFLLH 289
Cdd:smart00969   2 SLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLY 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
132-183 6.32e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 6.32e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148708804  132 SPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVACAKKLL 183
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 251-288 8.70e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.04  E-value: 8.70e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLL 288
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 133-248 1.23e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.20  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 133 PIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVACKNQQVA-----CAKKLLESGVSVN-QGKGLDSPLHVVA--R 204
Cdd:PHA03100  38 PLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNaPDNNGITPLLYAIskK 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148708804 205 MSSVELVHLLMDFGANAQAKNADGKRPVDLVpLESP-----LIQIFLQN 248
Cdd:PHA03100 118 SNSYSIVEYLLDNGANVNIKNSDGENLLHLY-LESNkidlkILKLLIDK 165
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 249-288 1.34e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.43  E-value: 1.34e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIrqhHKISELLLPEDLKRFLL 288
Cdd:cd03717    1 TSVRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLK 37
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 251-289 2.45e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 40.87  E-value: 2.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 249-289 2.54e-05

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 40.62  E-value: 2.54e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNH 41
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 251-290 4.16e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 40.15  E-value: 4.16e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLHL 290
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 249-289 7.52e-05

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 39.83  E-value: 7.52e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148708804 249 EGPQSLRQLCRLRIRKCFG---IRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGrlrLRCPVFMSFLPLPNRLKAYILY 44
PHA03095 PHA03095
ankyrin-like protein; Provisional
 114-233 1.79e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 114 VNLLLQHGATPHPETELAS-PIHEAAKRGYVKC---IESLAAHGANIDYNISHLGTPL-YVACKNQQVACAKKLLESGVS 188
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKtPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGAD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 148708804 189 VNQGKGLD-SPLHVVARMSSV--ELVHLLMDFGANAQAKNADGKRPVD 233
Cdd:PHA03095 110 VNAKDKVGrTPLHVYLSGFNInpKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 34-122 2.04e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  34 SPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLrgHLSCASVLLSHGAQVNGMTIDWRTPLFNA----Cvsg 109
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppC--- 266

                         90
                 ....*....|...
gi 148708804 110 SQDCVNLLLQHGA 122
Cdd:PHA02874 267 DIDIIDILLYHKA 279
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 251-289 3.33e-04

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 37.67  E-value: 3.33e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 148708804 251 PQSLRQLCRLRIRKCFGiRQH-HKISELLLPEDLKRFLLH 289
Cdd:cd03718    3 PLPLMDLCRRRVRVALG-RDRlEEIEQLPLPPSLKNYLLY 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-191 4.43e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  35 PLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSgSQDCV 114
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAI 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148708804 115 NLLLQHGATPHPETELASPIHEAAKRGYVK-CIESLAAHGANIDYNISHLGTPLYVACKN-QQVACAKKLLESGVSVNQ 191
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPCDIdIIDILLYHKADISIKDNKGENPIDTAFKYiNKDPVIKDIIANAVLIKE 317
PHA03095 PHA03095
ankyrin-like protein; Provisional
 84-228 5.64e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  84 LLSHGAQVNGMTIDWRTPLFNACVSGSQDC---VNLLLQHGATPH-PETELASPIHEAAKRGYV-KCIESLAAHGANIDY 158
Cdd:PHA03095  33 LLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNaPERCGFTPLHLYLYNATTlDVIKLLIKAGADVNA 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148708804 159 NISHLGTPLYVACKNQQVA--CAKKLLESGVSVNQGKGLD-SPLHVVARMS--SVELVHLLMDFGANAQAKNADG 228
Cdd:PHA03095 113 KDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNALDLYGmTPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRF 187
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-147 5.92e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 5.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 148708804   98 WRTPLFNACVSGSQDCVNLLLQHGATP-HPETELASPIHEAAKRGYVKCIE 147
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVLK 51
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 251-289 1.06e-03

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 36.36  E-value: 1.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03726    3 PRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKH 41
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 249-289 1.29e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 36.35  E-value: 1.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKIS---ELLLPEDLKRFLLH 289
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGLQKLQQPSsmkKLPLPPALKRYILY 44
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 249-289 1.82e-03

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 35.38  E-value: 1.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148708804 249 EGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLY 41
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 179-234 1.89e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 1.89e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 179 AKKLLESGVSVN----QGKgldSPLHVVARMSSVELVHLLMDFGANAQAKNADGKRPVDL 234
Cdd:PTZ00322  98 ARILLTGGADPNcrdyDGR---TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLEL 154
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 34-147 1.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  34 SPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEACLR-GHLSCASVLLSHGAQVNGM-TIDWRTPLFNACvsGSQ 111
Cdd:PHA02878 203 SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKsYILGLTALHSSI--KSE 280

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 148708804 112 DCVNLLLQHGATPHP-ETELASPIHEAAKRGYvkCIE 147
Cdd:PHA02878 281 RKLKLLLEYGADINSlNSYKLTPLSSAVKQYL--CIN 315
PHA02946 PHA02946
ankyin-like protein; Provisional
 48-235 2.24e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.27  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  48 LRNLISQGWPVNIITADHVSPLHEACLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNacVSGSQDCV----NLLLQHGAT 123
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYY--LSGTDDEVieriNLLVQYGAK 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 124 PHP--ETELASPI---HEAAKRGYVKcIESLAAHGANID-YNISHLGTplYVACKNQQVACAKKLLESGVSVNQ-GKGLD 196
Cdd:PHA02946 133 INNsvDEEGCGPLlacTDPSERVFKK-IMSIGFEARIVDkFGKNHIHR--HLMSDNPKASTISWMMKLGISPSKpDHDGN 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148708804 197 SPLHVVAR--MSSVELVHLLMDfGANAQAKNADGKRPVDLV 235
Cdd:PHA02946 210 TPLHIVCSktVKNVDIINLLLP-STDVNKQNKFGDSPLTLL 249
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 81-152 2.26e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 2.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148708804  81 ASVLLSHGAQVNGMTIDWRTPLFNACVSGSQDCVNLLLQHGATPHP-ETELASPIHEAAKRGYVKCIESLAAH 152
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLlDKDGKTPLELAEENGFREVVQLLSRH 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 3.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 3.02e-03
                           10        20
                   ....*....|....*....|....*....
gi 148708804    64 DHVSPLHEACLRGHLSCASVLLSHGAQVN 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 149-231 3.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.11  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 149 LAAHGANIDYNISHLGTPLYVACKNQQVACAKKLLESGVSVN-QGKGLDSPLHVVARMSSVELVHLLM-------DFGAN 220
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGAN 180

                         90
                 ....*....|.
gi 148708804 221 AQAKNADGKRP 231
Cdd:PTZ00322 181 AKPDSFTGKPP 191
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 32-122 3.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.89  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  32 DWSPLHDAAIHGCLLTLRNLISQGWPVNIITADHVSPLHEA-CLRGHLSCASVLLSHGAQVNGMTIDWRTPLFNACVSGS 110
Cdd:PHA02876 375 DKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNC 454

                         90
                 ....*....|...
gi 148708804 111 Q-DCVNLLLQHGA 122
Cdd:PHA02876 455 KlDVIEMLLDNGA 467
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 100-173 3.92e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.04  E-value: 3.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148708804 100 TPLFNACVSGSQDCVNLLLQHGATPHPETELA--SPIHEAAKRGYVKCIESLAAHGANIDYNISHLGTPLYVA---CKN 173
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkiTPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELAlmiCNN 150
PHA03095 PHA03095
ankyrin-like protein; Provisional
 40-190 4.20e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804  40 AIHGCLL-------TLRNLISQGWPVNIITADHVSPLHeACLRGHLSCASV---LLSHGAQVNGMTIDWRTPLFNACVS- 108
Cdd:PHA03095 120 PLHVYLSgfninpkVIRLLLRKGADVNALDLYGMTPLA-VLLKSRNANVELlrlLIDAGADVYAVDDRFRSLLHHHLQSf 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148708804 109 -GSQDCVNLLLQHGATPHPETELA-SPIHEAAKRGYVKC--IESLAAHGANIDYNISHLGTPLYVA-CKNQQVACAkKLL 183
Cdd:PHA03095 199 kPRARIVRELIRAGCDPAATDMLGnTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACR-RLI 277


                 ....*..
gi 148708804 184 ESGVSVN 190
Cdd:PHA03095 278 ALGADIN 284
Ank_4 pfam13637
Ankyrin repeats (many copies);
165-214 5.12e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 5.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 148708804  165 TPLYVACKNQQVACAKKLLESGVSVN-QGKGLDSPLHVVARMSSVELVHLL 214
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINaVDGNGETALHFAASNGNVEVLKLL 53
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 251-288 6.08e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 34.19  E-value: 6.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 148708804   251 PQSLRQLCRLRIRKCFGIRQhhkISELLLPEDLKRFLL 288
Cdd:smart00253   7 VPSLQHLCRFTIRRCTRTDQ---IKTLPLPPKLKDYLS 41
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 251-287 6.77e-03

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 33.78  E-value: 6.77e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 148708804 251 PQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFL 287
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYL 39
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 97-125 9.44e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 9.44e-03
                           10        20
                   ....*....|....*....|....*....
gi 148708804    97 DWRTPLFNACVSGSQDCVNLLLQHGATPH 125
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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