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Conserved domains on  [gi|149021407|gb|EDL78870|]
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similar to low density lipoprotein receptor-related protein binding protein (predicted), isoform CRA_b [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 5.10e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  10 EDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVR 89
Cdd:COG0666  100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100
                 ....*....|....*....|....*..
gi 149021407  90 IDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLL 205
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 5.10e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  10 EDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVR 89
Cdd:COG0666  100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100
                 ....*....|....*....|....*..
gi 149021407  90 IDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-116 6.30e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 6.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   36 HLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASdVRIDLCNkNGQTAEDLAWSCGFPECARF 115
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  .
gi 149021407  116 L 116
Cdd:pfam12796  80 L 80
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 13-99 1.40e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  13 LKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDL 92
Cdd:PHA02874 140 IKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMN 218


                 ....*..
gi 149021407  93 CNKNGQT 99
Cdd:PHA02874 219 KCKNGFT 225
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 3.71e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 3.71e-03
                           10        20
                   ....*....|....*....|....*....
gi 149021407    64 GETPLHKAAKVGSLECLSLLVASDVRIDL 92
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 5.10e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  10 EDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVR 89
Cdd:COG0666  100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100
                 ....*....|....*....|....*..
gi 149021407  90 IDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-116 6.71e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 6.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  13 LKNLLETGASVNAPpDPQEQSPVHLAAGGG---LACFLLwqlQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVR 89
Cdd:COG0666  136 VKLLLEAGADVNAQ-DNDGNTPLHLAAANGnleIVKLLL---EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                         90       100
                 ....*....|....*....|....*..
gi 149021407  90 IDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-116 1.47e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.61  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   1 MLLLSCNLEEDGLKNLLETGASVNAPPDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECL 80
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 149021407  81 SLLVASDVRIDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-116 6.30e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 6.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   36 HLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASdVRIDLCNkNGQTAEDLAWSCGFPECARF 115
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  .
gi 149021407  116 L 116
Cdd:pfam12796  80 L 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-116 1.31e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  16 LLETGASVNAPpDPQEQSPVHLAAGGG---LACFLLwqlQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDL 92
Cdd:COG0666  172 LLEAGADVNAR-DNDGETPLHLAAENGhleIVKLLL---EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247

                         90       100
                 ....*....|....*....|....
gi 149021407  93 CNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  248 KDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-116 5.34e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 5.34e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149021407   66 TPLHKAAKVGSLECLSLLVASDVRIDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-116 8.14e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 8.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   1 MLLLSCNLEEDGLKNLLETGASVNAPPDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECL 80
Cdd:COG0666   24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 149021407  81 SLLVASDVRIDLCNKNGQTAEDLAWSCGFPECARFL 116
Cdd:COG0666  104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
Ank_2 pfam12796
Ankyrin repeats (3 copies);
11-92 5.34e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 5.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   11 DGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLAcFLLWQLQTGADLNQQDvLGETPLHKAAKVGSLECLSLLVASDVRI 90
Cdd:pfam12796  11 ELVKLLLENGADANLQ-DKNGRTALHLAAKNGHL-EIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87


                  ..
gi 149021407   91 DL 92
Cdd:pfam12796  88 NV 89
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-104 7.39e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 7.39e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 149021407   55 ADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDLCNKNGQTAEDLA 104
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 1.05e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 1.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 149021407   33 SPVHLAAGGGlaCFLLWQ--LQTGADLNQQDVLGETPLHKAAKVGSLECLSLLV 84
Cdd:pfam13637   3 TALHAAAASG--HLELLRllLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 13-99 1.40e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  13 LKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDL 92
Cdd:PHA02874 140 IKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMN 218


                 ....*..
gi 149021407  93 CNKNGQT 99
Cdd:PHA02874 219 KCKNGFT 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-116 4.20e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.80  E-value: 4.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149021407   68 LHKAAKVGSLECLSLLVASDVRIDLCNKNGQTAedLAWSC--GFPECARFL 116
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTA--LHLAAknGHLEIVKLL 49
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-121 2.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   8 LEEDGLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASD 87
Cdd:PHA02874 102 IEKDMIKTILDCGIDVNIK-DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 149021407  88 VRIDLCNKNGQTAEDLAWSCGFPECARFL------TMIKC 121
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLidhgnhIMNKC 220
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 36-139 3.57e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 3.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  36 HLAAGG-GLACFLLwqLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDLCNKNGQTAEDLAWSCGFPECAR 114
Cdd:PTZ00322  88 QLAASGdAVGARIL--LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90       100
                 ....*....|....*....|....*
gi 149021407 115 FLTmikctqtaKSSREHPEGDPYAP 139
Cdd:PTZ00322 166 LLS--------RHSQCHFELGANAK 182
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 28-135 4.13e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.47  E-value: 4.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407  28 DPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDLCNKNGQTAEDLAWSC 107
Cdd:PLN03192 522 DPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISA 601

                         90       100
                 ....*....|....*....|....*...
gi 149021407 108 GFPECARFLtmikcTQTAKSSREHPEGD 135
Cdd:PLN03192 602 KHHKIFRIL-----YHFASISDPHAAGD 624
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 13-84 1.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.32  E-value: 1.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149021407  13 LKNLLETGASVNAPPDPQEQSPVHLAAGGGLACFLLwqLQTGADLNQQDVLGETPLHKAAKVGS-LECLSLLV 84
Cdd:PHA02878 251 LKLLLEHGVDVNAKSYILGLTALHSSIKSERKLKLL--LEYGADINSLNSYKLTPLSSAVKQYLcINIGRILI 321
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-99 2.19e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 37.34  E-value: 2.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 149021407  54 GADLNQQDVLGETPLHKAAKVGSLECLSLLVASDVRIDLCNKNGQT 99
Cdd:PHA03100 182 GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 15-68 2.68e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 36.93  E-value: 2.68e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 149021407  15 NLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPL 68
Cdd:PHA03095 242 PLLIAGISINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-83 3.27e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 36.80  E-value: 3.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149021407  12 GLKNLLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQLQTGADLNQQDVLGETPLHKAAKVGSLECLSLL 83
Cdd:PTZ00322  97 GARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 51-90 3.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.97  E-value: 3.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149021407  51 LQTGADLNQQDVLGETPLHKAAKVGSLECLSLLVA--SDVRI 90
Cdd:PHA02876 165 LEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSygADVNI 206
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 64-92 3.71e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 3.71e-03
                           10        20
                   ....*....|....*....|....*....
gi 149021407    64 GETPLHKAAKVGSLECLSLLVASDVRIDL 92
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 9-120 5.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 36.18  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   9 EEDGLKNLLETGASVNAPPDpQEQSPVHLAAGGG--------LACFLLwqlQTGADLNQQDVLGETPLHKAA--KVGSLE 78
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTK-NNSTPLHYLSNIKynltdvkeIVKLLL---EYGANVNAPDNNGITPLLYAIskKSNSYS 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 149021407  79 CLSLLVASDVRIDLCNKNGQTAEDLAWSCGFPEcarfLTMIK 120
Cdd:PHA03100 123 IVEYLLDNGANVNIKNSDGENLLHLYLESNKID----LKILK 160
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 64-95 6.07e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.03  E-value: 6.07e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 149021407   64 GETPLHKAA-KVGSLECLSLLVASDVRIDLCNK 95
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 16-75 6.74e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.19  E-value: 6.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149021407  16 LLETGASVNAPpDPQEQSPVHLAAGG-GLACFLLWQLQTGADLNQQDVLGETPLHKAAKVG 75
Cdd:PHA02876 259 LYDAGFSVNSI-DDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 8-99 7.71e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 35.63  E-value: 7.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149021407   8 LEEDGLKNLLETGASVNAPPDPQEQSPVHLAAGG---GLACFLLWQlqtGADLNQQDVLGETPLHKAAKVGSLECLSLLV 84
Cdd:PHA02878 145 IEAEITKLLLSYGADINMKDRHKGNTALHYATENkdqRLTELLLSY---GANVNIPDKTNNSPLHHAVKHYNKPIVHILL 221

                         90
                 ....*....|....*
gi 149021407  85 ASDVRIDLCNKNGQT 99
Cdd:PHA02878 222 ENGASTDARDKCGNT 236
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-69 8.12e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 35.77  E-value: 8.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149021407   2 LLLSCNLEE--DGLKNLLETGASVNAPpDPQEQSPVHLaagggLACF--------LLwqLQTGADLNQQDVLGETPLH 69
Cdd:PHA03095  53 LYLHYSSEKvkDIVRLLLEAGADVNAP-ERCGFTPLHL-----YLYNattldvikLL--IKAGADVNAKDKVGRTPLH 122
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 16-72 9.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 35.42  E-value: 9.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 149021407  16 LLETGASVNAPpDPQEQSPVHLAAGGGLACFLLWQL-QTGADLNQQDVLGETPLHKAA 72
Cdd:PHA02876 293 LLERGADVNAK-NIKGETPLYLMAKNGYDTENIRTLiMLGADVNAADRLYITPLHQAS 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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