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Conserved domains on  [gi|149043742|gb|EDL97193|]
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calcineurin binding protein 1, isoform CRA_a [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MEF2_binding pfam09047
MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the ...
 2118-2152 1.09e-15

MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription.


:

Pssm-ID: 370261 [Multi-domain]  Cd Length: 35  Bit Score: 72.58  E-value: 1.09e-15
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149043742  2118 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2152
Cdd:pfam09047    1 TLLSPKGSISEETKQKLKNAILSAQSAANVKKDSL 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-205 1.13e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLilkYSTYKNLAQLAAQREDLETA 109
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----------------LDPDD---AEALYNLGLAYLRLGRYEEA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  110 MEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDC 189
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170
                  ....*....|....*.
gi 149043742  190 RYSKGLVLKEKIFEEQ 205
Cdd:COG0457   142 DDADALYNLGIALEKL 157
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1914-2156 2.89e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1914 AAAQRQASGDAP---TTPKHPKDSRENF-FPATVAPSAPDTTAPD--ALQRPSDSHLKPGLAAAITCPPSASASTPDPGI 1987
Cdd:PHA03247 2581 AVTSRARRPDAPpqsARPRAPVDDRGDPrGPAPPSPLPPDTHAPDppPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR 2660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1988 PQPHRPEAVPSRAPlspdgeEVSGVTEGPSflsqepRHSHQMKMAATGPLAEQHcwPVEAACQTGAEPTFSQATSTKVPS 2067
Cdd:PHA03247 2661 VSRPRRARRLGRAA------QASSPPQRPR------RRAARPTVGSLTSLADPP--PPPPTPEPAPHALVSATPLPPGPA 2726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 2068 SGSTQTPESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEIT-----VTPPTPTLLSPKGSISEETKQKLKSAILSAQ 2142
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250
                  ....*....|....
gi 149043742 2143 SAANVRKESLCQPA 2156
Cdd:PHA03247 2807 PPAAVLAPAAALPP 2820
 
Name Accession Description Interval E-value
MEF2_binding pfam09047
MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the ...
 2118-2152 1.09e-15

MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription.


Pssm-ID: 370261 [Multi-domain]  Cd Length: 35  Bit Score: 72.58  E-value: 1.09e-15
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149043742  2118 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2152
Cdd:pfam09047    1 TLLSPKGSISEETKQKLKNAILSAQSAANVKKDSL 35
MEF2_binding cd13839
Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; ...
 2118-2152 6.39e-14

Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; The myocyte enhancer factor-2 (MEF2) binding domain, as found in the calcineurin-binding protein cabin-1, adopts an amphipathic alpha-helical structure, which allows it to bind to a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription. Cabin-1 inhibits calcineurin-mediated signal transduction in T-cell receptor-mediated signalling pathways, by binding to the activated form of calcineurin. Cabin-1 acts as a co-repressor of MEF2, the mycocyte enhancer factor-2, which regulates transcription in a calcium-dependent manner and plays vital roles in T-cell development and function.


Pssm-ID: 260103 [Multi-domain]  Cd Length: 35  Bit Score: 67.41  E-value: 6.39e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 149043742 2118 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2152
Cdd:cd13839     1 TLLSPKGSISEETKQKLKNAILSSQSAANVKKDTL 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-205 1.13e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLilkYSTYKNLAQLAAQREDLETA 109
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----------------LDPDD---AEALYNLGLAYLRLGRYEEA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  110 MEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDC 189
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170
                  ....*....|....*.
gi 149043742  190 RYSKGLVLKEKIFEEQ 205
Cdd:COG0457   142 DDADALYNLGIALEKL 157
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1914-2156 2.89e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1914 AAAQRQASGDAP---TTPKHPKDSRENF-FPATVAPSAPDTTAPD--ALQRPSDSHLKPGLAAAITCPPSASASTPDPGI 1987
Cdd:PHA03247 2581 AVTSRARRPDAPpqsARPRAPVDDRGDPrGPAPPSPLPPDTHAPDppPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR 2660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1988 PQPHRPEAVPSRAPlspdgeEVSGVTEGPSflsqepRHSHQMKMAATGPLAEQHcwPVEAACQTGAEPTFSQATSTKVPS 2067
Cdd:PHA03247 2661 VSRPRRARRLGRAA------QASSPPQRPR------RRAARPTVGSLTSLADPP--PPPPTPEPAPHALVSATPLPPGPA 2726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 2068 SGSTQTPESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEIT-----VTPPTPTLLSPKGSISEETKQKLKSAILSAQ 2142
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250
                  ....*....|....
gi 149043742 2143 SAANVRKESLCQPA 2156
Cdd:PHA03247 2807 PPAAVLAPAAALPP 2820
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1915-2155 1.48e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 1.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1915 AAQRQASGDAPTTPKHPKDSRENFFPATVAPS-------------------------------------APDTTAPDALQ 1957
Cdd:pfam17823   37 AGKQNASGDAVPRADNKSSEQ*NFCAATAAPApvtltkgtsaahlnstevtaehtphgtdlsepatregAADGAASRALA 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1958 RP---SDSHLKPGLAAAITCPPSASASTPDPGIPQPhrPEAVPSRAPLSpdgeevsgVTEGPSFLSQEPRHSHQMKMAAT 2034
Cdd:pfam17823  117 AAassSPSSAAQSLPAAIAALPSEAFSAPRAAACRA--NASAAPRAAIA--------AASAPHAASPAPRTAASSTTAAS 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  2035 GPLAEQHCWPVEA----ACQTGAEPTFSQATSTKVPSSGS--TQTPESHQGKTESSRAKSRLLPNMPKLVIPSATT--KF 2106
Cdd:pfam17823  187 STTAASSAPTTAAssapATLTPARGISTAATATGHPAAGTalAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTvaSA 266

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 149043742  2107 PPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQP 2155
Cdd:pfam17823  267 AGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQP 315
TPR_12 pfam13424
Tetratricopeptide repeat;
36-119 1.96e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742    36 AFALYHKALDLQKHDRFEESAKAYHELLEarlLREAVSSGDekeglkHPGLILkysTYKNLAQLAAQREDLETAMEFYLE 115
Cdd:pfam13424    3 ATALNNLAAVLRRLGRYDEALELLEKALE---IARRLLGPD------HPLTAT---TLLNLGRLYLELGRYEEALELLER 70


                   ....
gi 149043742   116 AVML 119
Cdd:pfam13424   71 ALAL 74
 
Name Accession Description Interval E-value
MEF2_binding pfam09047
MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the ...
 2118-2152 1.09e-15

MEF2 binding; The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription.


Pssm-ID: 370261 [Multi-domain]  Cd Length: 35  Bit Score: 72.58  E-value: 1.09e-15
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149043742  2118 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2152
Cdd:pfam09047    1 TLLSPKGSISEETKQKLKNAILSAQSAANVKKDSL 35
MEF2_binding cd13839
Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; ...
 2118-2152 6.39e-14

Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1; The myocyte enhancer factor-2 (MEF2) binding domain, as found in the calcineurin-binding protein cabin-1, adopts an amphipathic alpha-helical structure, which allows it to bind to a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription. Cabin-1 inhibits calcineurin-mediated signal transduction in T-cell receptor-mediated signalling pathways, by binding to the activated form of calcineurin. Cabin-1 acts as a co-repressor of MEF2, the mycocyte enhancer factor-2, which regulates transcription in a calcium-dependent manner and plays vital roles in T-cell development and function.


Pssm-ID: 260103 [Multi-domain]  Cd Length: 35  Bit Score: 67.41  E-value: 6.39e-14
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 149043742 2118 TLLSPKGSISEETKQKLKSAILSAQSAANVRKESL 2152
Cdd:cd13839     1 TLLSPKGSISEETKQKLKNAILSSQSAANVKKDTL 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
30-205 1.13e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLilkYSTYKNLAQLAAQREDLETA 109
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----------------LDPDD---AEALYNLGLAYLRLGRYEEA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  110 MEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKDC 189
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170
                  ....*....|....*.
gi 149043742  190 RYSKGLVLKEKIFEEQ 205
Cdd:COG0457   142 DDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-199 1.93e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.49  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   34 AEAFALYHKALDLQkhdrfEESAKAYHELleARLLREAvssGDEKEGLKH--------PGLIlkySTYKNLAQLAAQRED 105
Cdd:COG0457    25 EEAIEDYEKALELD-----PDDAEALYNL--GLAYLRL---GRYEEALADyeqaleldPDDA---EALNNLGLALQALGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  106 LETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKAL 185
Cdd:COG0457    92 YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLE 171

                         170
                  ....*....|....
gi 149043742  186 EKDCRYSKGLVLKE 199
Cdd:COG0457   172 AAALAALLAAALGE 185
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 27-188 1.03e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   27 QTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEARLLREAvssGDEKEGLKHPGLILK-----YSTYKNLAQLAA 101
Cdd:COG3914    47 LLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL---GRYEEALALYRRALAlnpdnAEALFNLGNLLL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  102 QREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFI 181
Cdd:COG3914   124 ALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAY 203


                  ....*..
gi 149043742  182 CKALEKD 188
Cdd:COG3914   204 RRALELD 210
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 30-205 3.08e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   30 EAQEAEAFALYHKALDLQKHDRFEESAKAYHELLE---------ARLLREAVSSGDEKEGLKHPGLILKYS-----TYKN 95
Cdd:COG2956    70 ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEldpddaealRLLAEIYEQEGDWEKAIEVLERLLKLGpenahAYCE 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   96 LAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYT 175
Cdd:COG2956   150 LAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPE 229

                         170       180       190
                  ....*....|....*....|....*....|
gi 149043742  176 TCLYFICKALEKDCRYSKGLVLKEKIFEEQ 205
Cdd:COG2956   230 EALELLRKALELDPSDDLLLALADLLERKE 259
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 33-188 3.59e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 3.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   33 EAEAFALYHKALDLQKHDRFEESAKAYHELLEArllreavsSGDEKEGlkhpglilkystYKNLAQLAAQREDLETAMEF 112
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALEL--------DPDNPEA------------FALLGEILLQLGDLDEAIVL 60

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149043742  113 YLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKD 188
Cdd:COG4783    61 LHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1914-2156 2.89e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1914 AAAQRQASGDAP---TTPKHPKDSRENF-FPATVAPSAPDTTAPD--ALQRPSDSHLKPGLAAAITCPPSASASTPDPGI 1987
Cdd:PHA03247 2581 AVTSRARRPDAPpqsARPRAPVDDRGDPrGPAPPSPLPPDTHAPDppPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR 2660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1988 PQPHRPEAVPSRAPlspdgeEVSGVTEGPSflsqepRHSHQMKMAATGPLAEQHcwPVEAACQTGAEPTFSQATSTKVPS 2067
Cdd:PHA03247 2661 VSRPRRARRLGRAA------QASSPPQRPR------RRAARPTVGSLTSLADPP--PPPPTPEPAPHALVSATPLPPGPA 2726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 2068 SGSTQTPESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEIT-----VTPPTPTLLSPKGSISEETKQKLKSAILSAQ 2142
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                         250
                  ....*....|....
gi 149043742 2143 SAANVRKESLCQPA 2156
Cdd:PHA03247 2807 PPAAVLAPAAALPP 2820
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 38-188 6.29e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.11  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   38 ALYHKALDLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAV 117
Cdd:COG5010     2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149043742  118 MLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYFICKALEKD 188
Cdd:COG5010    82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1915-2155 1.48e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 1.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1915 AAQRQASGDAPTTPKHPKDSRENFFPATVAPS-------------------------------------APDTTAPDALQ 1957
Cdd:pfam17823   37 AGKQNASGDAVPRADNKSSEQ*NFCAATAAPApvtltkgtsaahlnstevtaehtphgtdlsepatregAADGAASRALA 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1958 RP---SDSHLKPGLAAAITCPPSASASTPDPGIPQPhrPEAVPSRAPLSpdgeevsgVTEGPSFLSQEPRHSHQMKMAAT 2034
Cdd:pfam17823  117 AAassSPSSAAQSLPAAIAALPSEAFSAPRAAACRA--NASAAPRAAIA--------AASAPHAASPAPRTAASSTTAAS 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  2035 GPLAEQHCWPVEA----ACQTGAEPTFSQATSTKVPSSGS--TQTPESHQGKTESSRAKSRLLPNMPKLVIPSATT--KF 2106
Cdd:pfam17823  187 STTAASSAPTTAAssapATLTPARGISTAATATGHPAAGTalAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTvaSA 266

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 149043742  2107 PPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESLCQP 2155
Cdd:pfam17823  267 AGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQP 315
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1752-2122 1.70e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1752 RPPVGPTEPMDTGEtaARHPDLEPTPRLlPGRPPRDRGPESRSAELSLEELSiSTRQQPAPLVPSPVTPTTAAPTTMGAR 1831
Cdd:PHA03247 2572 RPAPRPSEPAVTSR--ARRPDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPD-THAPDPPPPSPSPAANEPDPHPPPTVP 2647

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1832 AAGHPEEAPP-----RPNRKRKLLQDTESGKTLLLDAYRVWQQGQKAMAyDLSRIEKimsetymliKQVDEETALEQAVK 1906
Cdd:PHA03247 2648 PPERPRDDPApgrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADPPP---------PPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1907 FCQVHLGAAAQRQASGDAPTTPKHPKDSRENFFPATVAPSA--PDTTAPDALQRPSDSHLKPglAAAITCPPSASASTPD 1984
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArpPTTAGPPAPAPPAAPAAGP--PRRLTRPAVASLSESR 2795

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1985 PGIPQPHRPEAVP------------SRAPLSPDGEEVSGVTEGPSFLSQEPRHSHQM--KMAATGPLAEQHcwPVEAACQ 2050
Cdd:PHA03247 2796 ESLPSPWDPADPPaavlapaaalppAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggSVAPGGDVRRRP--PSRSPAA 2873

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149043742 2051 TGAEPTFSQATSTKVPSSgSTQTPESHQGKTESSRAKSrllPNMPKLVIPSATTKFPPEITVTPPTPTLLSP 2122
Cdd:PHA03247 2874 KPAAPARPPVRRLARPAV-SRSTESFALPPDQPERPPQ---PQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP 2941
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
99-188 2.00e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   99 LAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARhAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL 178
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|
gi 149043742  179 YFICKALEKD 188
Cdd:COG3063    80 AYLERALELD 89
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
29-174 6.62e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.53  E-value: 6.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   29 KEAQEAEAFALYHKALDLQKHDRFEE-------SAKAYHELLEARLLREAVSSGDEKEGLKHPGLIlkySTYKNLAQLAA 101
Cdd:COG4785     8 LLLALALAAAAASKAAILLAALLFAAvlalaiaLADLALALAAAALAAAALAAERIDRALALPDLA---QLYYERGVAYD 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149043742  102 QREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDY 174
Cdd:COG4785    85 SLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 95-174 1.35e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   95 NLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDY 174
Cdd:COG4235    22 LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDY 101
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1-155 2.17e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.88  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742    1 MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKALDLQKhdRFEESAKAYHELLEArllreavssgdekeg 80
Cdd:COG5010    21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLG--DFEESLALLEQALQL--------------- 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149043742   81 lkHPGlilKYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNP 155
Cdd:COG5010    84 --DPN---NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1751-2137 4.01e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1751 ERPPVGPTEPMDTGETAARHPDLEPTPRLLP--GRPPRDRGPESRSAELSLEELSISTRQQPAPLVPSPVTPTTaapttm 1828
Cdd:pfam03154  177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPpqGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQ------ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1829 garaaGHPEEAPPRPNRKRKLLQDTESGKTLLLDayRVWQQGQKAMAYDLSriekimSETYMLIKQVDEETALEQAVKFC 1908
Cdd:pfam03154  251 -----PMTQPPPPSQVSPQPLPQPSLHGQMPPMP--HSLQTGPSHMQHPVP------PQPFPLTPQSSQSQVPPGPSPAA 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1909 QVHLGAAAQRQASGDAPTTPKHPKDSRENFFPATVAPSAPDTTAPDALQRPSDSHLKPGLAAAiTCPPSASASTPDP--- 1985
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSG-PSPFQMNSNLPPPpal 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  1986 ----GIPQPHRPEAVPSRAPLSPDGEEVSGVTEGPSFLSQEPRH----SHQMKMAATGPLAEQHCWPVEAACQTGAEPTF 2057
Cdd:pfam03154  397 kplsSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLpppaASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIT 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742  2058 SQAT-STKVPSSGSTQTPEShqgktESSRAKSRLLPNMPKLVIPSATTKFPP-----EITVTPPTPTLLSPKGSISEETK 2131
Cdd:pfam03154  477 PPSGpPTSTSSAMPGIQPPS-----SASVSSSGPVPAAVSCPLPPVQIKEEAldeaeEPESPPPPPRSPSPEPTVVNTPS 551


                   ....*.
gi 149043742  2132 QKLKSA 2137
Cdd:pfam03154  552 HASQSA 557
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
92-158 4.32e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 4.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149043742   92 TYKNLAQLAAQREDLETAMEFyLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHW 158
Cdd:COG3063    28 ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSAL 93
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 34-174 7.02e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742   34 AEAFALYHKALDLQKHDRFEESAKAYHELLEarllreavssgdekeglKHPGLIlkySTYKNLAQLAAQREDLETAMEFY 113
Cdd:COG2956     6 AAALGWYFKGLNYLLNGQPDKAIDLLEEALE-----------------LDPETV---EAHLALGNLYRRRGEYDRAIRIH 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149043742  114 LEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDY 174
Cdd:COG2956    66 QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126
TPR_12 pfam13424
Tetratricopeptide repeat;
36-119 1.96e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742    36 AFALYHKALDLQKHDRFEESAKAYHELLEarlLREAVSSGDekeglkHPGLILkysTYKNLAQLAAQREDLETAMEFYLE 115
Cdd:pfam13424    3 ATALNNLAAVLRRLGRYDEALELLEKALE---IARRLLGPD------HPLTAT---TLLNLGRLYLELGRYEEALELLER 70


                   ....
gi 149043742   116 AVML 119
Cdd:pfam13424   71 ALAL 74
TPR_21 pfam09976
Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.
 48-151 4.02e-03

Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.


Pssm-ID: 430959 [Multi-domain]  Cd Length: 194  Bit Score: 40.65  E-value: 4.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742    48 KHDRFEESAKAYHELLEArllreaVSSGDEKEGL--------KHPGlilkySTYKNLAQL-----AAQREDLETAMEfYL 114
Cdd:pfam09976   32 QRSQAEEASALYQQLLEA------VAAGDAAKAQaaaaqlkdEYGG-----TGYAALAALllakaAVEAGDLAAAKA-QL 99

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 149043742   115 EAVMLDSTDVNLwykiGHVA-LRLIRLPLARHAFEEGL 151
Cdd:pfam09976  100 EWVADNAKDEAL----KALArLRLARVLLAQGKYDEAL 133
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1920-2085 5.68e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1920 ASGDAPTTPKHPKDsrenffPATVAPSAPDTTAPDALQRPSDSHLKPGLAAAITCPP---SASASTPDPGIPQPHRPEAV 1996
Cdd:PHA03307  158 SPAAVASDAASSRQ------AALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRrssPISASASSPAPAPGRSAADD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1997 PSRAPLSPDGEEVSGVTEGPsfLSQEPRHSHQMKMAATGPLAEQHCWPVEAACQTGAEPTFSQ----ATSTKVPSSGSTQ 2072
Cdd:PHA03307  232 AGASSSDSSSSESSGCGWGP--ENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRerspSPSPSSPGSGPAP 309

                         170
                  ....*....|...
gi 149043742 2073 TPESHQGKTESSR 2085
Cdd:PHA03307  310 SSPRASSSSSSSR 322
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1690-2108 8.03e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1690 VSHKASPEDgQESLPHPKKLPLADGSGPGPEPGGKVGPLHQLPVATDTRDNTEQGGEPKDKERPPVGPTEPMDTGETAAR 1769
Cdd:PHA03247 2695 LTSLADPPP-PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1770 HPDLEPTPRLLP----------GRPPRDRGPESRSAELSLEELSISTRQQPAPLVPSPVTPttaapttmgARAAGHPEEA 1839
Cdd:PHA03247 2774 APAAGPPRRLTRpavaslsesrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA---------QPTAPPPPPG 2844

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1840 PPRPnrkrkllqdtesgkTLLLdayrvwqQGQKAMAYDLSRiekimsetymlikqvdeetaleqavkfcqvhlgaAAQRQ 1919
Cdd:PHA03247 2845 PPPP--------------SLPL-------GGSVAPGGDVRR----------------------------------RPPSR 2869

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1920 ASGDAPTTPKHPKDSRENfFPATVAPSAPDTTAPDALQRP--SDSHLKPGLAAAITCPPSASASTPDPGIPQP-----HR 1992
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLA-RPAVSRSTESFALPPDQPERPpqPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPplaptTD 2948

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149043742 1993 PEAVPSRAPLSPD---GEEVSGVTEGPSFLSQEPRHSHQMKMAATGPLAEQH-----CWPVEAACQTGAEPTFSQATSTK 2064
Cdd:PHA03247 2949 PAGAGEPSGAVPQpwlGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSlsrvsSWASSLALHEETDPPPVSLKQTL 3028

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 149043742 2065 VPSSGSTQTPESHQGKTESSRAKSRLL-PNMPKLVIPSATTKFPP 2108
Cdd:PHA03247 3029 WPPDDTEDSDADSLFDSDSERSDLEALdPLPPEPHDPFAHEPDPA 3073
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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