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Conserved domains on  [gi|332364484|gb|EGJ42255|]
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XRE family transcriptional regulator [Streptococcus sanguinis SK355]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-66 4.32e-07

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 44.60  E-value: 4.32e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 332364484   6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYLLGLANRSAIEQLGSEKK 66
Cdd:COG1396   23 QEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEEE 83
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-66 4.32e-07

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 44.60  E-value: 4.32e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 332364484   6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYLLGLANRSAIEQLGSEKK 66
Cdd:COG1396   23 QEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEEE 83
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-49 3.82e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 36.38  E-value: 3.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 332364484   6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYL 49
Cdd:cd00093   15 QEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-49 2.16e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.42  E-value: 2.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 332364484     6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYL 49
Cdd:smart00530  13 QEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 6-49 2.84e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.05  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 332364484    6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYL 49
Cdd:pfam01381  12 QEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-66 4.32e-07

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 44.60  E-value: 4.32e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 332364484   6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYLLGLANRSAIEQLGSEKK 66
Cdd:COG1396   23 QEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEEE 83
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
7-52 2.11e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 37.13  E-value: 2.11e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 332364484   7 ERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYLLGL 52
Cdd:COG1476   21 EELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSL 66
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-49 3.82e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 36.38  E-value: 3.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 332364484   6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYL 49
Cdd:cd00093   15 QEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-49 2.16e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.42  E-value: 2.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 332364484     6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYL 49
Cdd:smart00530  13 QEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 6-49 2.84e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.05  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 332364484    6 LERLAEILHVSKAAVCKWESNTNLPKVMELKNMSSLFHVSADYL 49
Cdd:pfam01381  12 QEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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