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Conserved domains on  [gi|344240178|gb|EGV96281|]
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Nuclear mitotic apparatus protein 1 [Cricetulus griseus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRPV super family cl40437
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 2230-2897 1.10e-116

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


The actual alignment was detected with superfamily member TIGR00870:

Pssm-ID: 454755 [Multi-domain]  Cd Length: 743  Bit Score: 389.83  E-value: 1.10e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2230 TLLGAIQEGQLGIVQQLLEsgsdasggGPLRNVEESEDRSWREAL-NLAIRLGHEAITDVLLaNIKFDFRQIHEALLVAV 2308
Cdd:TIGR00870   20 AFLPAAERGDLASVYRDLE--------EPKKLNINCPDRLGRSALfVAAIENENLELTELLL-NLSCRGAVGDTLLHAIS 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2309 DTNQPAVVRCLLARLEREKgrkvDTKSFSLAFfdsSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIarphPVSCA 2388
Cdd:TIGR00870   91 LEYVDAVEAILLHLLAAFR----KSGPLELAN---DQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASV----PARAC 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2389 CLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASED--AMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFEL 2466
Cdd:TIGR00870  160 GDFFVKSQGVDSFYHGESPLNAAACLGSPSIVALLSEDpaDILTADSLGNTLLHLLVMENEFKAEYEELSCQMYNFALSL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2467 LGMCRNQSEVTAVLNDLGEDSETepeseglgQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGST 2546
Cdd:TIGR00870  240 LDKLRDSKELEVILNHQGLTPLK--------LAAKEGRIVLFRLKLAIKYKQKKFVAWPNGQQLLSLYWLEELDGWRRKQ 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2547 TIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGHLLKIPVLKFLLHSASYLWFLI--------------------------- 2599
Cdd:TIGR00870  312 SVLELIVVFVIGLKFPELSDMYLIAPLSRLGQFKWKPFIKFIFHSASYLYFLYliiftsvayyrptrtdlrvtglqqtpl 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2600 ----------FLLGESLVMETQLSTFKGRSQ-SVWETSLHMIWV------------------TERSEWRTEDPQFLAEVL 2650
Cdd:TIGR00870  392 emlivtwvdgLRLGEEKLIWLGGIFEYIHQLwNILDFGMNSFYLatfldrpfailfvtqaflVLREHWLRFDPTLIEEAL 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2651 FAVTSMLSFTRLAYILPAHESLGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLNNIYVPYQETEKLGNFN-------- 2721
Cdd:TIGR00870  472 FAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMIlGDILRFLFIYAVVLFGFACGLNQLYQYYDELKLNECSNpharscek 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2722 ---------ETFQFLFWTMFGMEEhtVVDMPQFLVpEFVGRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKF 2792
Cdd:TIGR00870  552 qgnaystlfETSQELFWAIIGLGD--LLANEHKFT-EFVGLLLFGAYNVIMYILLLNMLIAMMGNTYQLIADDADEEWKF 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2793 ARSKLYLSYFREGLTLPVPFNILPSPKAAFYLVRRIFWFLCCCSSCCKAKKSDYppiptFTNPGARARPGEGERGSYRLR 2872
Cdd:TIGR00870  629 QRAKLWMSYEREGGTCPPPFNIIPGPKSFVGLFKRIEKHDGKKRQRWCRRVEEV-----NWTTWERKAETLIEDGLHYQR 703

                          730       740
                   ....*....|....*....|....*..
gi 344240178  2873 VVKALVQRYI--ETARREFEETRRKDL 2897
Cdd:TIGR00870  704 VMKRLIKRYVlaEQRPRDDEGTTEEET 730
XRCC1_N pfam01834
XRCC1 N terminal domain;
1925-2059 5.51e-59

XRCC1 N terminal domain;


:

Pssm-ID: 460356  Cd Length: 148  Bit Score: 200.54  E-value: 5.51e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1925 DPKYPVENLLNPDNHRgPWLSCPRDkSGQLKVELQLERVVPISYIDVGNCGCAFLQIDVGRSSWPLDKPFVTLLPATMLM 2004
Cdd:pfam01834   16 DPVHPAENLLKSDTYR-KWKCAKPG-EKQASVELQLERASQITSIDIGNEGSAFVEVLVGRSSWPDDQDFEVLLVTSSFM 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  2005 SLADSKEGKNRSGVRMFKNDDFLTPASGESWDRLRLLCSQPFTRHQSFGLAFVQV 2059
Cdd:pfam01834   94 TPSESKNGTNRNRVRMFGKDKLNSSAAEEKWDRVKIVCTQPFNKTVQYGLSFIKF 148
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 437-1026 7.41e-33

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 140.07  E-value: 7.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  437 LRQQVEqlssslKLKEQ--QLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEA 514
Cdd:COG1196   198 LERQLE------PLERQaeKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  515 ANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLA 594
Cdd:COG1196   272 LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE---EELEELEEELEE 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  595 LEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQR------EQEQKALEQEKAGRKGLEARLQQLEEARQA 668
Cdd:COG1196   349 AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALraaaelAAQLEELEEAEEALLERLERLEEELEELEE 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  669 ETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVHGEG 748
Cdd:COG1196   429 ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLE 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  749 QIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLvLKAGEQQEMTSLELLKEPPGAG 828
Cdd:COG1196   509 GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY-LKAAKAGRATFLPLDKIRARAA 587

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  829 NKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKA 908
Cdd:COG1196   588 LAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSR 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  909 AKAELEVRlqntlneqrvefAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAG 988
Cdd:COG1196   668 RELLAALL------------EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAERE 735

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 344240178  989 STGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLE 1026
Cdd:COG1196   736 ELLEELLEEEELLEEEALEELPEPPDLEELERELERLE 773
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 137-707 3.46e-29

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 128.13  E-value: 3.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  137 EKDAQIAMMQQRIDHLAL-LNEKQAASSQESRELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEEngdls 215
Cdd:COG1196   236 ELEAELEELEAELEELEAeLEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER----- 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  216 fkvrefashLQQLQGAFNDLTEEHnkasQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQE 295
Cdd:COG1196   311 ---------RRELEERLEELEEEL----AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  296 KGEVLGDALQLETLKQEAAKLAAHNTQLQARIETL---DCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQA 372
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALlerLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  373 KEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKE 452
Cdd:COG1196   458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE 537

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  453 QQLEEAAkdqEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQE 532
Cdd:COG1196   538 AALEAAL---AAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  533 KAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQItkgsLEEEKHR 612
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE----LAERLAE 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  613 TADALAEQQrcvtkmEAESRSLMEQREQEQKALEQEKAGRKgLEARLQQLEEARQAETEALRRELAEATASQHRAESESE 692
Cdd:COG1196   691 EELELEEAL------LAEEEEERELAEAEEERLEEELEEEA-LEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763

                         570
                  ....*....|....*
gi 344240178  693 QLIREVESWQKRFEA 707
Cdd:COG1196   764 ELERELERLEREIEA 778
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 611-1536 2.40e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.47  E-value: 2.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   611 HRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKG----LEARLQQLEEAR---QAETEALRRELAEATAS 683
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSLERQAEKAERYKELKAELRELelalLVLRLEELREELeelQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   684 QHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQlaalkgdhekagqeaqeeavevhgEGQIGEQQSPLAQLHTT 763
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL------------------------EQQKQILRERLANLERQ 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   764 LARALQQVKEKEVRAQKLADDLTTLQEKMASTskvaaclktlvlkageQQEMTSLEllkeppgagnkesnwleeqrggpf 843
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEELAELEEKLEEL----------------KEELESLE------------------------ 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   844 sspqAALKAMEQEAEQMGSELERLRVALmksqgqqqeerGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNE 923
Cdd:TIGR02168  358 ----AELEELEAELEELESRLEELEEQL-----------ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQE 422

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   924 QRVEFAALQEALDHAL-TEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGStggeEASAPEAQL 1002
Cdd:TIGR02168  423 IEELLKKLEEAELKELqAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA----RLDSLERLQ 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1003 ETVRKteaPDPEVEALRAEVSKLEQQCQQQKQQV---EGLTHSLESERASRAE------QDKALETLQGQ---------- 1063
Cdd:TIGR02168  499 ENLEG---FSEGVKALLKNQSGLSGILGVLSELIsvdEGYEAAIEAALGGRLQavvvenLNAAKKAIAFLkqnelgrvtf 575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1064 LEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKA---------------QVARGQQEAERKSSLISSLEEEVs 1128
Cdd:TIGR02168  576 LPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvddlDNALELAKKLRPGYRIVTLDGDL- 654

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1129 ILNRQVLEKEGESKELKRLvvAESEKSQKLEERLRLLQVETASSSARAAErssaLREEVQSLREEVEKQRVISENLRQEL 1208
Cdd:TIGR02168  655 VRPGGVITGGSAKTNSSIL--ERRREIEELEEKIEELEEKIAELEKALAE----LRKELEELEEELEQLRKELEELSRQI 728

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1209 TSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGL 1288
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1289 RAELMRaqrelgelgpLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEEnrglgeranlgrqfleveldqarek 1368
Cdd:TIGR02168  809 RAELTL----------LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSED------------------------- 853

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1369 yVQELAAVRTDAETHLAEMRQEAQSttrelevmtakyegakvkVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQ 1448
Cdd:TIGR02168  854 -IESLAAEIEELEELIEELESELEA------------------LLNERASLEEALALLRSELEELSEELRELESKRSELR 914

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1449 QKLKAFQAQGGESQQEVQRLQAQLNELQtqlsqkEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLrdleqlqkenKELR 1528
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQ------ERLSEEYSLTLEEAEALENKIEDDEEEARRRL----------KRLE 978


                   ....*...
gi 344240178  1529 AEAERLGR 1536
Cdd:TIGR02168  979 NKIKELGP 986
NuMA_LGNBD cd22298
LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins; ...
 1686-1744 3.92e-27

LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also called nuclear matrix protein-22 (NMP-22), nuclear mitotic apparatus protein 1 (NUMA1), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of spindle poles and the alignment and segregation of chromosomes during mitotic cell division. It is involved in the establishment of mitotic spindle orientation during metaphase, and elongation during anaphase in a dynein-dynactin-dependent manner. NuMA, in complex with LGN, forms NuMA:LGN hetero-hexamers that promote spindle orientation. The model corresponds to the LGN binding domain (LGNBD) of NuMA. LGN (named for leu-gly-asn repeats) is also known as G protein signaling modulator 2.


:

Pssm-ID: 412093  Cd Length: 56  Bit Score: 106.14  E-value: 3.92e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178 1686 LLSLPGYRPTTRSSARRSQarmSSGAPQGRNSFYMGTCQDEPEQLDDWNRIAELQQRNR 1744
Cdd:cd22298     1 LLSLPGYRPSTRSSTRRSQ---SSSATGGRSTFYMGTCQDEPEHLDDWNRIAELQQRNR 56
HkD_SF super family cl41774
Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor ...
 1-44 9.24e-08

Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor proteins, Hook-related proteins and nuclear mitotic apparatus protein (NuMA). They share an N-terminal conserved globular Hook domain, which folds as a variant of the helical calponin homology (CH) domain with an extended alpha-helix. The Hook domain is responsible for the binding of microtubule. The Hook family includes microtubule-binding proteins, Hook1-3. Hook1 is required for spermatid differentiation. Hook2 contributes to the establishment and maintenance of centrosome function. Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking, and is involved in Golgi and endosome transport. Hook proteins are components of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex. The Hook-related protein (HkRP) family includes Daple, Girdin and Gipie. Daple, also called Dvl-associating protein with a high frequency of leucine residues, or coiled-coil domain-containing protein 88C(CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Gipie, also called GRP78-interacting protein induced by ER stress, or coiled-coil domain-containing protein 88B(CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. NuMA, also called nuclear mitotic apparatus protein 1, or nuclear matrix protein-22 (NMP-22), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignment and the segregation of chromosomes during mitotic cell division.


The actual alignment was detected with superfamily member cd22224:

Pssm-ID: 425405  Cd Length: 148  Bit Score: 53.73  E-value: 9.24e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 344240178    1 MSSRNPrdWEQFEYRIQAELAVILKFMLDHEDSLNLIEDLENFL 44
Cdd:cd22224   106 MNNNLT--LEKLDYKTELELASILRFVLDNEDGLYLSEGLDKFL 147
 
Name Accession Description Interval E-value
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 2230-2897 1.10e-116

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 389.83  E-value: 1.10e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2230 TLLGAIQEGQLGIVQQLLEsgsdasggGPLRNVEESEDRSWREAL-NLAIRLGHEAITDVLLaNIKFDFRQIHEALLVAV 2308
Cdd:TIGR00870   20 AFLPAAERGDLASVYRDLE--------EPKKLNINCPDRLGRSALfVAAIENENLELTELLL-NLSCRGAVGDTLLHAIS 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2309 DTNQPAVVRCLLARLEREKgrkvDTKSFSLAFfdsSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIarphPVSCA 2388
Cdd:TIGR00870   91 LEYVDAVEAILLHLLAAFR----KSGPLELAN---DQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASV----PARAC 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2389 CLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASED--AMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFEL 2466
Cdd:TIGR00870  160 GDFFVKSQGVDSFYHGESPLNAAACLGSPSIVALLSEDpaDILTADSLGNTLLHLLVMENEFKAEYEELSCQMYNFALSL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2467 LGMCRNQSEVTAVLNDLGEDSETepeseglgQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGST 2546
Cdd:TIGR00870  240 LDKLRDSKELEVILNHQGLTPLK--------LAAKEGRIVLFRLKLAIKYKQKKFVAWPNGQQLLSLYWLEELDGWRRKQ 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2547 TIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGHLLKIPVLKFLLHSASYLWFLI--------------------------- 2599
Cdd:TIGR00870  312 SVLELIVVFVIGLKFPELSDMYLIAPLSRLGQFKWKPFIKFIFHSASYLYFLYliiftsvayyrptrtdlrvtglqqtpl 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2600 ----------FLLGESLVMETQLSTFKGRSQ-SVWETSLHMIWV------------------TERSEWRTEDPQFLAEVL 2650
Cdd:TIGR00870  392 emlivtwvdgLRLGEEKLIWLGGIFEYIHQLwNILDFGMNSFYLatfldrpfailfvtqaflVLREHWLRFDPTLIEEAL 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2651 FAVTSMLSFTRLAYILPAHESLGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLNNIYVPYQETEKLGNFN-------- 2721
Cdd:TIGR00870  472 FAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMIlGDILRFLFIYAVVLFGFACGLNQLYQYYDELKLNECSNpharscek 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2722 ---------ETFQFLFWTMFGMEEhtVVDMPQFLVpEFVGRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKF 2792
Cdd:TIGR00870  552 qgnaystlfETSQELFWAIIGLGD--LLANEHKFT-EFVGLLLFGAYNVIMYILLLNMLIAMMGNTYQLIADDADEEWKF 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2793 ARSKLYLSYFREGLTLPVPFNILPSPKAAFYLVRRIFWFLCCCSSCCKAKKSDYppiptFTNPGARARPGEGERGSYRLR 2872
Cdd:TIGR00870  629 QRAKLWMSYEREGGTCPPPFNIIPGPKSFVGLFKRIEKHDGKKRQRWCRRVEEV-----NWTTWERKAETLIEDGLHYQR 703

                          730       740
                   ....*....|....*....|....*..
gi 344240178  2873 VVKALVQRYI--ETARREFEETRRKDL 2897
Cdd:TIGR00870  704 VMKRLIKRYVlaEQRPRDDEGTTEEET 730
XRCC1_N pfam01834
XRCC1 N terminal domain;
1925-2059 5.51e-59

XRCC1 N terminal domain;


Pssm-ID: 460356  Cd Length: 148  Bit Score: 200.54  E-value: 5.51e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1925 DPKYPVENLLNPDNHRgPWLSCPRDkSGQLKVELQLERVVPISYIDVGNCGCAFLQIDVGRSSWPLDKPFVTLLPATMLM 2004
Cdd:pfam01834   16 DPVHPAENLLKSDTYR-KWKCAKPG-EKQASVELQLERASQITSIDIGNEGSAFVEVLVGRSSWPDDQDFEVLLVTSSFM 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  2005 SLADSKEGKNRSGVRMFKNDDFLTPASGESWDRLRLLCSQPFTRHQSFGLAFVQV 2059
Cdd:pfam01834   94 TPSESKNGTNRNRVRMFGKDKLNSSAAEEKWDRVKIVCTQPFNKTVQYGLSFIKF 148
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 437-1026 7.41e-33

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 140.07  E-value: 7.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  437 LRQQVEqlssslKLKEQ--QLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEA 514
Cdd:COG1196   198 LERQLE------PLERQaeKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  515 ANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLA 594
Cdd:COG1196   272 LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE---EELEELEEELEE 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  595 LEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQR------EQEQKALEQEKAGRKGLEARLQQLEEARQA 668
Cdd:COG1196   349 AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALraaaelAAQLEELEEAEEALLERLERLEEELEELEE 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  669 ETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVHGEG 748
Cdd:COG1196   429 ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLE 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  749 QIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLvLKAGEQQEMTSLELLKEPPGAG 828
Cdd:COG1196   509 GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY-LKAAKAGRATFLPLDKIRARAA 587

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  829 NKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKA 908
Cdd:COG1196   588 LAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSR 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  909 AKAELEVRlqntlneqrvefAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAG 988
Cdd:COG1196   668 RELLAALL------------EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAERE 735

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 344240178  989 STGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLE 1026
Cdd:COG1196   736 ELLEELLEEEELLEEEALEELPEPPDLEELERELERLE 773
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 100-794 1.74e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 139.42  E-value: 1.74e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   100 LQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIdhLALLNEKQAASSQE---SRELEELRGKN 176
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL--YALANEISRLEQQKqilRERLANLERQL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   177 ESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEkqthLEKE 256
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ----LELQ 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   257 LSTALQDKKYLEEKNEILQGKLSQLEERASQQceSPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQ 336
Cdd:TIGR02168  395 IASLNNEIERLEARLERLEDRRERLQQEIEEL--LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEE 472

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   337 QEAQLLAERGHFEEEKQQLASLiADLQSSISNLSQAKEELEQAsQAQGAQLTAQVASL--------TALNTTLQQQQDQE 408
Cdd:TIGR02168  473 AEQALDAAERELAQLQARLDSL-ERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyeAAIEAALGGRLQAV 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   409 LASLKEQAKKEQAQMVQSL----------QEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAE 478
Cdd:TIGR02168  551 VVENLNAAKKAIAFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDD 630

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   479 AREA-SLRERDAARQQLETLEKEKAAKLESLqqqleaaNEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQA 557
Cdd:TIGR02168  631 LDNAlELAKKLRPGYRIVTLDGDLVRPGGVI-------TGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAEL 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   558 QAHVTELEAQLkaeqqkvaerEKVMQEKAQLQEQLLALEETLQItkgsLEEEKHRTADALAEQQRCVTKMEAESRSLMEQ 637
Cdd:TIGR02168  704 RKELEELEEEL----------EQLRKELEELSRQISALRKDLAR----LEAEVEQLEERIAQLSKELTELEAEIEELEER 769

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   638 REQEQKALEQEKAGRKGLEARLQQLEEARQAETE---ALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEAR 714
Cdd:TIGR02168  770 LEEAEEELAEAEAEIEELEAQIEQLKEELKALREaldELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEE 849

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   715 ysamIQEQLAALKGDHEKAGQ--EAQEEAVEVHGEgQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKM 792
Cdd:TIGR02168  850 ----LSEDIESLAAEIEELEEliEELESELEALLN-ERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL 924


                   ..
gi 344240178   793 AS 794
Cdd:TIGR02168  925 AQ 926
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 137-707 3.46e-29

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 128.13  E-value: 3.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  137 EKDAQIAMMQQRIDHLAL-LNEKQAASSQESRELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEEngdls 215
Cdd:COG1196   236 ELEAELEELEAELEELEAeLEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER----- 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  216 fkvrefashLQQLQGAFNDLTEEHnkasQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQE 295
Cdd:COG1196   311 ---------RRELEERLEELEEEL----AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  296 KGEVLGDALQLETLKQEAAKLAAHNTQLQARIETL---DCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQA 372
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALlerLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  373 KEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKE 452
Cdd:COG1196   458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE 537

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  453 QQLEEAAkdqEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQE 532
Cdd:COG1196   538 AALEAAL---AAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  533 KAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQItkgsLEEEKHR 612
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE----LAERLAE 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  613 TADALAEQQrcvtkmEAESRSLMEQREQEQKALEQEKAGRKgLEARLQQLEEARQAETEALRRELAEATASQHRAESESE 692
Cdd:COG1196   691 EELELEEAL------LAEEEEERELAEAEEERLEEELEEEA-LEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763

                         570
                  ....*....|....*
gi 344240178  693 QLIREVESWQKRFEA 707
Cdd:COG1196   764 ELERELERLEREIEA 778
PTZ00121 PTZ00121
MAEBL; Provisional
 452-1244 1.26e-27

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 124.10  E-value: 1.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  452 EQQLEEAAKDQEAARQDhaqqlaIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEaanearDSVQTSVTQVQQ 531
Cdd:PTZ00121 1030 EELTEYGNNDDVLKEKD------IIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKE------DNRADEATEEAF 1097

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  532 EKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAErEKVMQEKAQLQEQLLALEETLQITKGSLEEEKH 611
Cdd:PTZ00121 1098 GKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAE-EARKAEDAKRVEIARKAEDARKAEEARKAEDAK 1176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  612 RTADAL-AEQQRCVTKMEA--ESRSLMEQR--EQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHR 686
Cdd:PTZ00121 1177 KAEAARkAEEVRKAEELRKaeDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRK 1256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  687 AESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEvhgegqigeqqsplaqlhttlAR 766
Cdd:PTZ00121 1257 FEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEE---------------------AK 1315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  767 ALQQVKEKEVRAQKLADDLttlqEKMASTSKVAACLKtlvlKAGEQQEMTSLELLKEPPGAGNKESNwlEEQRGGPFSSP 846
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAA----KKKAEEAKKAAEAA----KAEAEAAADEAEAAEEKAEAAEKKKE--EAKKKADAAKK 1385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  847 QAA-------LKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQaQADLAQEKAAKAELEVRLQN 919
Cdd:PTZ00121 1386 KAEekkkadeAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAK-KADEAKKKAEEAKKAEEAKK 1464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  920 TLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELK----ELQQTLEHLKTQLVKKEKEQHPAGSTGGEEA 995
Cdd:PTZ00121 1465 KAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKkkadEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  996 SAPEAQL---ETVRKTEAPDPEVEALRAE------VSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEE 1066
Cdd:PTZ00121 1545 KKKADELkkaEELKKAEEKKKAEEAKKAEedknmaLRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE 1624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1067 KTQELGHSQAASASAQRELTALHaKAQDHSKAEEEWK---AQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKE 1143
Cdd:PTZ00121 1625 LKKAEEEKKKVEQLKKKEAEEKK-KAEELKKAEEENKikaAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKK 1703

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1144 LKRLVVAESEKSQKLE-----ERLRLLQVETASssaRAAERSSALREEVQslREEVEKQRVisenlRQELTSQAERAEEL 1218
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEelkkaEEENKIKAEEAK---KEAEEDKKKAEEAK--KDEEEKKKI-----AHLKKEEEKKAEEI 1773

                         810       820
                  ....*....|....*....|....*.
gi 344240178 1219 GQELKAWQEKFFQKEQALSALQLEHT 1244
Cdd:PTZ00121 1774 RKEKEAVIEEELDEEDEKRRMEVDKK 1799
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 611-1536 2.40e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.47  E-value: 2.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   611 HRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKG----LEARLQQLEEAR---QAETEALRRELAEATAS 683
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSLERQAEKAERYKELKAELRELelalLVLRLEELREELeelQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   684 QHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQlaalkgdhekagqeaqeeavevhgEGQIGEQQSPLAQLHTT 763
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL------------------------EQQKQILRERLANLERQ 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   764 LARALQQVKEKEVRAQKLADDLTTLQEKMASTskvaaclktlvlkageQQEMTSLEllkeppgagnkesnwleeqrggpf 843
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEELAELEEKLEEL----------------KEELESLE------------------------ 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   844 sspqAALKAMEQEAEQMGSELERLRVALmksqgqqqeerGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNE 923
Cdd:TIGR02168  358 ----AELEELEAELEELESRLEELEEQL-----------ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQE 422

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   924 QRVEFAALQEALDHAL-TEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGStggeEASAPEAQL 1002
Cdd:TIGR02168  423 IEELLKKLEEAELKELqAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA----RLDSLERLQ 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1003 ETVRKteaPDPEVEALRAEVSKLEQQCQQQKQQV---EGLTHSLESERASRAE------QDKALETLQGQ---------- 1063
Cdd:TIGR02168  499 ENLEG---FSEGVKALLKNQSGLSGILGVLSELIsvdEGYEAAIEAALGGRLQavvvenLNAAKKAIAFLkqnelgrvtf 575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1064 LEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKA---------------QVARGQQEAERKSSLISSLEEEVs 1128
Cdd:TIGR02168  576 LPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvddlDNALELAKKLRPGYRIVTLDGDL- 654

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1129 ILNRQVLEKEGESKELKRLvvAESEKSQKLEERLRLLQVETASSSARAAErssaLREEVQSLREEVEKQRVISENLRQEL 1208
Cdd:TIGR02168  655 VRPGGVITGGSAKTNSSIL--ERRREIEELEEKIEELEEKIAELEKALAE----LRKELEELEEELEQLRKELEELSRQI 728

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1209 TSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGL 1288
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1289 RAELMRaqrelgelgpLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEEnrglgeranlgrqfleveldqarek 1368
Cdd:TIGR02168  809 RAELTL----------LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSED------------------------- 853

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1369 yVQELAAVRTDAETHLAEMRQEAQSttrelevmtakyegakvkVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQ 1448
Cdd:TIGR02168  854 -IESLAAEIEELEELIEELESELEA------------------LLNERASLEEALALLRSELEELSEELRELESKRSELR 914

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1449 QKLKAFQAQGGESQQEVQRLQAQLNELQtqlsqkEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLrdleqlqkenKELR 1528
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQ------ERLSEEYSLTLEEAEALENKIEDDEEEARRRL----------KRLE 978


                   ....*...
gi 344240178  1529 AEAERLGR 1536
Cdd:TIGR02168  979 NKIKELGP 986
NuMA_LGNBD cd22298
LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins; ...
 1686-1744 3.92e-27

LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also called nuclear matrix protein-22 (NMP-22), nuclear mitotic apparatus protein 1 (NUMA1), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of spindle poles and the alignment and segregation of chromosomes during mitotic cell division. It is involved in the establishment of mitotic spindle orientation during metaphase, and elongation during anaphase in a dynein-dynactin-dependent manner. NuMA, in complex with LGN, forms NuMA:LGN hetero-hexamers that promote spindle orientation. The model corresponds to the LGN binding domain (LGNBD) of NuMA. LGN (named for leu-gly-asn repeats) is also known as G protein signaling modulator 2.


Pssm-ID: 412093  Cd Length: 56  Bit Score: 106.14  E-value: 3.92e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178 1686 LLSLPGYRPTTRSSARRSQarmSSGAPQGRNSFYMGTCQDEPEQLDDWNRIAELQQRNR 1744
Cdd:cd22298     1 LLSLPGYRPSTRSSTRRSQ---SSSATGGRSTFYMGTCQDEPEHLDDWNRIAELQQRNR 56
TRP_2 pfam08344
Transient receptor ion channel II; This domain is found in the transient receptor ion channel ...
 2387-2446 2.31e-26

Transient receptor ion channel II; This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).


Pssm-ID: 462438  Cd Length: 60  Bit Score: 103.82  E-value: 2.31e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2387 CACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARKEP 2446
Cdd:pfam08344    1 CGCDECKAERERDSLRHSLSRLNAYRALASPAYISLTSEDPILTAFELSWELRRLAFVEP 60
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1036-1578 1.49e-25

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 116.57  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1036 VEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAER 1115
Cdd:COG1196   227 AELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIAR 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1116 KSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVE 1195
Cdd:COG1196   307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1196 KQRviseNLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR 1275
Cdd:COG1196   387 ELL----EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1276 EEIEQSKQAAGGLRAELMRAQRELGELGPlRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRG-------LG 1348
Cdd:COG1196   463 ELLAELLEEAALLEAALAELLEELAEAAA-RLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVeaayeaaLE 541

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1349 ERANLGRQFLEVELDQAREKYVQELAAVRTDAETHL---AEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQ----- 1420
Cdd:COG1196   542 AALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYvlgdt 621

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1421 -EERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKT- 1498
Cdd:COG1196   622 lLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLa 701

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1499 HYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGK 1578
Cdd:COG1196   702 EEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGP 781
PTZ00121 PTZ00121
MAEBL; Provisional
 547-1526 5.38e-25

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 115.24  E-value: 5.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  547 IEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEE-KHRTADALAEQQRcvt 625
Cdd:PTZ00121 1052 IDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEArKAEEAKKKAEDAR--- 1128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 KMEAESRSlmeqrEQEQKALEQEKAGRKGLEARLQQLEEARQAEtEALRRELAEATASQHRAESeseqlIREVESWQKRF 705
Cdd:PTZ00121 1129 KAEEARKA-----EDARKAEEARKAEDAKRVEIARKAEDARKAE-EARKAEDAKKAEAARKAEE-----VRKAEELRKAE 1197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  706 EARQQEEARysamiqeqlaalKGDHEKAGQEAQEEAVEVHGEGqigeqqsplaqlhttlARALQQVKEKEVRAQKLADDL 785
Cdd:PTZ00121 1198 DARKAEAAR------------KAEEERKAEEARKAEDAKKAEA----------------VKKAEEAKKDAEEAKKAEEER 1249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  786 TTLQEKMASTSKVAA-CLKTLVLKAGEQQEMTSLELLKEPPGAgnKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSEL 864
Cdd:PTZ00121 1250 NNEEIRKFEEARMAHfARRQAAIKAEEARKADELKKAEEKKKA--DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA 1327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  865 ERLRVALMKsqgqqqeergqqerevaRLTRERSQAQADLAQEKAAKAELEVrlqntlNEQRVEFAALQealdhalTEKEG 944
Cdd:PTZ00121 1328 KKKADAAKK-----------------KAEEAKKAAEAAKAEAEAAADEAEA------AEEKAEAAEKK-------KEEAK 1377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  945 KDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAgstggEEAsapEAQLETVRKT-EAPDPEVEALRAEVS 1023
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKA-----DEA---KKKAEEKKKAdEAKKKAEEAKKADEA 1449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1024 KleqQCQQQKQQVEGLTHSLESERAS-----RAEQDKALETLQGQLEE---KTQELGHSQAASASAQRELTALHA-KAQD 1094
Cdd:PTZ00121 1450 K---KKAEEAKKAEEAKKKAEEAKKAdeakkKAEEAKKADEAKKKAEEakkKADEAKKAAEAKKKADEAKKAEEAkKADE 1526

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1095 HSKAEEEWKAQVARGQQEAERKSSLISSLE----EEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETA 1170
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKAEElkkaEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1171 --SSSARAAERSSALREEVQslREEVEKQRVisENLRQELTSQAERAEELGqelKAWQEKFFQKEQalsalqlehtstqa 1248
Cdd:PTZ00121 1607 mkAEEAKKAEEAKIKAEELK--KAEEEKKKV--EQLKKKEAEEKKKAEELK---KAEEENKIKAAE-------------- 1665

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1249 lvsellpakhlcqqlQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRAE---KAS 1325
Cdd:PTZ00121 1666 ---------------EAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKI 1730

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1326 YAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKY 1405
Cdd:PTZ00121 1731 KAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANI 1810

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1406 -EGAKvkvlEERQRFQEERQKLTAQVEELS-KKLTEYDQASKVQQQKLKAfQAQGGESQQEVQRLQAQLNELQTQLSQKE 1483
Cdd:PTZ00121 1811 iEGGK----EGNLVINDSKEMEDSAIKEVAdSKNMQLEEADAFEKHKFNK-NNENGEDGNKEADFNKEKDLKEDDEEEIE 1885

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*.
gi 344240178 1484 QAAEHYKLQ---MEKAKTHYDAKKQQNQELQDQLrDLEQLQKENKE 1526
Cdd:PTZ00121 1886 EADEIEKIDkddIEREIPNNNMAGKNNDIIDDKL-DKDEYIKRDAE 1930
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 145-1228 4.42e-21

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 101.79  E-value: 4.42e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   145 MQQRIDHLALLNEKQaasSQESRELEELRGKNESLT---VRLHETLKQCQNLKTEKNQMDRKIS----QLSEENGDLSFK 217
Cdd:pfam01576    7 MQAKEEELQKVKERQ---QKAESELKELEKKHQQLCeekNALQEQLQAETELCAEAEEMRARLAarkqELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   218 VREFASHLQQLQGAFNDLTE-----EHNKASQEWAEKQTHLEKeLSTALQDKKY------LEEKNEILQGKLSQLEERAS 286
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQhiqdlEEQLDEEEAARQKLQLEK-VTTEAKIKKLeedillLEDQNSKLSKERKLLEERIS 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   287 QQCESPAQEKGEVlgDALQLETLKQEAAKlaahnTQLQARIETldCERSQQEaqllaerghFEEEKQQLASLIADLQSSI 366
Cdd:pfam01576  163 EFTSNLAEEEEKA--KSLSKLKNKHEAMI-----SDLEERLKK--EEKGRQE---------LEKAKRKLEGESTDLQEQI 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   367 SNLSQAKEELEqasqaqgAQLTAQVASLTALNTTLQQQQDQELASLKeQAKKEQAQmVQSLQEQEQAAQGLRQQVEQ--- 443
Cdd:pfam01576  225 AELQAQIAELR-------AQLAKKEEELQAALARLEEETAQKNNALK-KIRELEAQ-ISELQEDLESERAARNKAEKqrr 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   444 -LSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSV 522
Cdd:pfam01576  296 dLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANL 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQL-KAEQQKVAEREKVMQEKAQLQEQLLALEET--- 598
Cdd:pfam01576  376 EKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLsESERQRAELAEKLSKLQSELESVSSLLNEAegk 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   599 ---LQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLeearQAETEALRR 675
Cdd:pfam01576  456 nikLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTL----QAQLSDMKK 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   676 ELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAM---IQEQLAALKGDHEKAGQEAQE-EAVEVHGEGQIG 751
Cdd:pfam01576  532 KLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTknrLQQELDDLLVDLDHQRQLVSNlEKKQKKFDQMLA 611

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   752 EQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTlvlkageqqEMTSLELLKEPPGagnKE 831
Cdd:pfam01576  612 EEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRA---------EMEDLVSSKDDVG---KN 679

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   832 SNWLEEQRggpfsspqaalKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERsQAQADLAQEKAAKA 911
Cdd:pfam01576  680 VHELERSK-----------RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDL-QARDEQGEEKRRQL 747

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   912 ELEVR-LQNTLNEQRVEFAA-----------LQEALDHALTEKEGKDQELAKLRGQEAaqrtELKELQQTLEHLKTQlvk 979
Cdd:pfam01576  748 VKQVReLEAELEDERKQRAQavaakkkleldLKELEAQIDAANKGREEAVKQLKKLQA----QMKDLQRELEEARAS--- 820

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   980 keKEQHPAGSTggeeasapeaqlETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLE---SERASRAEQDKA 1056
Cdd:pfam01576  821 --RDEILAQSK------------ESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIAsgaSGKSALQDEKRR 886

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1057 LETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKS------------------- 1117
Cdd:pfam01576  887 LEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNkelkaklqemegtvkskfk 966

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1118 SLISSLEEEVSILNRQvLEKEGESKELKRLVVAESEKsqKLEERLrlLQVETASSSA--------RAAERSSALREEVQS 1189
Cdd:pfam01576  967 SSIAALEAKIAQLEEQ-LEQESRERQAANKLVRRTEK--KLKEVL--LQVEDERRHAdqykdqaeKGNSRMKQLKRQLEE 1041

                         1130      1140      1150
                   ....*....|....*....|....*....|....*....
gi 344240178  1190 LREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEK 1228
Cdd:pfam01576 1042 AEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 531-1573 7.16e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 91.39  E-value: 7.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   531 QEKAELSQKIEELHACIEAAHQEQRQAQAHVTE----LEAQLKAEQQKVAEREKVmqeKAQLQEQLLALEETLQITKGSL 606
Cdd:pfam01576    8 QAKEEELQKVKERQQKAESELKELEKKHQQLCEeknaLQEQLQAETELCAEAEEM---RARLAARKQELEEILHELESRL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   607 EEEKHRTADALAEQQrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHR 686
Cdd:pfam01576   85 EEEEERSQQLQNEKK----KMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEER 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   687 AESESEQLIREVEswqkRFEARQQEEARYSAMIQEQLAALKGDhEKAGQEAqeEAVEVHGEGQIGEQQSPLAQLHTTLAR 766
Cdd:pfam01576  161 ISEFTSNLAEEEE----KAKSLSKLKNKHEAMISDLEERLKKE-EKGRQEL--EKAKRKLEGESTDLQEQIAELQAQIAE 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   767 ALQQVKEKEvraQKLADDLTTLQEKMAStskvaaclKTLVLKAGEQQEMTSLELLKEppgagnkesnwLEEQRggpfssp 846
Cdd:pfam01576  234 LRAQLAKKE---EELQAALARLEEETAQ--------KNNALKKIRELEAQISELQED-----------LESER------- 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   847 qAALKAMEQEAEQMGSELERLRVALmksqgqqqeergqqerevarltrERSQAQADLAQEKAAKAELEVrlqntlneqrv 926
Cdd:pfam01576  285 -AARNKAEKQRRDLGEELEALKTEL-----------------------EDTLDTTAAQQELRSKREQEV----------- 329

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   927 efAALQEALDHaltEKEGKDQELAKLRGQEAAQrteLKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEA----SAPEAQL 1002
Cdd:pfam01576  330 --TELKKALEE---ETRSHEAQLQEMRQKHTQA---LEELTEQLEQAKRNKANLEKAKQALESENAELQaelrTLQQAKQ 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1003 ETVRKTEAPDPEVEALRAEVSkleqqcqqqkqqveglthslESERAsRAEQDKALETLQGQLEEKTQELGHSQAASASAQ 1082
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLS--------------------ESERQ-RAELAEKLSKLQSELESVSSLLNEAEGKNIKLS 460

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1083 RELTALHAKAQD-HSKAEEEWKAQVA---RGQQEAERKSSLISSLEEEVSI---LNRQVLEKEGESKELKRLVVAESEKS 1155
Cdd:pfam01576  461 KDVSSLESQLQDtQELLQEETRQKLNlstRLRQLEDERNSLQEQLEEEEEAkrnVERQLSTLQAQLSDMKKKLEEDAGTL 540

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1156 QKLEERLRLLQVETASSSARAAERSSA---LREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQ---ELKAWQEKF 1229
Cdd:pfam01576  541 EALEEGKKRLQRELEALTQQLEEKAAAydkLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQmlaEEKAISARY 620

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1230 F-QKEQALSALQLEHTSTQALVSELLPAKHLcQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQREL-GELGPLRQ 1307
Cdd:pfam01576  621 AeERDRAEAEAREKETRALSLARALEEALEA-KEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALeQQVEEMKT 699

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1308 KVAEQERAAQQLRAEKASYAEQLSMLKKAH--GLLAEENRGLGERANLGRQF--LEVELDQAREKYVQELAAvRTDAETH 1383
Cdd:pfam01576  700 QLEELEDELQATEDAKLRLEVNMQALKAQFerDLQARDEQGEEKRRQLVKQVreLEAELEDERKQRAQAVAA-KKKLELD 778

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1384 LAEMRQ--EAQSTTRELEVMTAKYEGAKVKvleERQRFQEE----RQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQ 1457
Cdd:pfam01576  779 LKELEAqiDAANKGREEAVKQLKKLQAQMK---DLQRELEEarasRDEILAQSKESEKKLKNLEAELLQLQEDLAASERA 855

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1458 GGESQQEVQRLQAQLN--------------ELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKE 1523
Cdd:pfam01576  856 RRQAQQERDELADEIAsgasgksalqdekrRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQK 935

                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1524 NKELRAEAERLGRELQqagLKTKEAEQACR-HLSAQVRSLEAQVAHADQQL 1573
Cdd:pfam01576  936 SESARQQLERQNKELK---AKLQEMEGTVKsKFKSSIAALEAKIAQLEEQL 983
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 137-700 4.89e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 85.56  E-value: 4.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   137 EKDAQIAMMQQRI----DHLALL-----NEKQAASSQESRELEELRGKNE----SLTVRLHETLKQCQNLKTE------- 196
Cdd:pfam15921  228 ELDTEISYLKGRIfpveDQLEALksesqNKIELLLQQHQDRIEQLISEHEveitGLTEKASSARSQANSIQSQleiiqeq 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   197 -KNQMDRKISQLSeengDLSFKVREFASHLQQLQGAFNDLTEEHNK----ASQEWAEKQThlekELSTALQDKKYLEEKN 271
Cdd:pfam15921  308 aRNQNSMYMRQLS----DLESTVSQLRSELREAKRMYEDKIEELEKqlvlANSELTEART----ERDQFSQESGNLDDQL 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   272 EILQGKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCE-RSQQEAQLLAERGHfEE 350
Cdd:pfam15921  380 QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSEcQGQMERQMAAIQGK-NE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   351 EKQQLASLIADLQSSISNLSQAKEELeqasqaqgaqltaqvaslTALNTTLqqqqdqelaslkEQAKKEQAQMVQSLQEQ 430
Cdd:pfam15921  459 SLEKVSSLTAQLESTKEMLRKVVEEL------------------TAKKMTL------------ESSERTVSDLTASLQEK 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   431 EQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDqeaarQDHAQQLAIVAEAREASLRERDaarQQLETLEKEkaakLESLQQ 510
Cdd:pfam15921  509 ERAIEATNAEITKLRSRVDLKLQELQHLKNE-----GDHLRNVQTECEALKLQMAEKD---KVIEILRQQ----IENMTQ 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   511 QLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQ-----------LKAEQQKVAERE 579
Cdd:pfam15921  577 LVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEkvklvnagserLRAVKDIKQERD 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   580 KVMQEKAQLQEQLLALEETLQITKGSLE---EEKHRTADALAEQQRCVTKMEAESRSLMEQRE-QEQKALEQEKAGRKGL 655
Cdd:pfam15921  657 QLLNEVKTSRNELNSLSEDYEVLKRNFRnksEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEgSDGHAMKVAMGMQKQI 736

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*
gi 344240178   656 EARLQQLeEARQAETEALRRELAEATASQHRAESESEQLIREVES 700
Cdd:pfam15921  737 TAKRGQI-DALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELST 780
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
96-722 1.94e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 83.19  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   96 MGDILQTPQFQMRRLKKQLADERNNRDELElelseslklltEKDAQIAMMQQRIDHLAL----LNEKQAASSQESRELEE 171
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTENIEELIK-----------EKEKELEEVLREINEISSelpeLREELEKLEKEVKELEE 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  172 LRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFAShLQQLQGAFNDLTEEHNKASQEWAEkqt 251
Cdd:PRK03918  236 LKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELRE--- 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  252 hLEKELSTALQDKKYLEEKNEILQGKLSQLEErASQQCESPAQEKGEVLGDALQLETLKQEAAKLaahnTQLQARIETLD 331
Cdd:PRK03918  312 -IEKRLSRLEEEINGIEERIKELEEKEERLEE-LKKKLKELEKRLEELEERHELYEEAKAKKEEL----ERLKKRLTGLT 385

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  332 CERSQQEAQLLAERG-HFEEEKQQLASLIADLQSSISNLSQAKEELEQASQ---AQGAQLTAQ-----VASLTALNTTLQ 402
Cdd:PRK03918  386 PEKLEKELEELEKAKeEIEEEISKITARIGELKKEIKELKKAIEELKKAKGkcpVCGRELTEEhrkelLEEYTAELKRIE 465

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  403 QQQdQELASLKEQAKKEQAQmVQSLQEQEQAAQGLRQQVEQLSS-SLKLKEQQLEEAAKDQEAARQdhaqqlaivaeare 481
Cdd:PRK03918  466 KEL-KEIEEKERKLRKELRE-LEKVLKKESELIKLKELAEQLKElEEKLKKYNLEELEKKAEEYEK-------------- 529

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  482 asLRER-DAARQQLETLEKEkAAKLESLQQQLEAANEARDSvqtsvtqVQQEKAELSQKIEEL-HACIEAAHQEQRQAQA 559
Cdd:PRK03918  530 --LKEKlIKLKGEIKSLKKE-LEKLEELKKKLAELEKKLDE-------LEEELAELLKELEELgFESVEELEERLKELEP 599

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  560 HVTELEAQLKAEQQKvaEREKVMQEKaqLQEQLLALEETLQITKGSLEEEKHRtadaLAEQQRcvtkmeaeSRSLMEQRE 639
Cdd:PRK03918  600 FYNEYLELKDAEKEL--EREEKELKK--LEEELDKAFEELAETEKRLEELRKE----LEELEK--------KYSEEEYEE 663

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  640 QEQKALEQEKAgRKGLEARLQQLEEARQaETEALRRELAEATASQHRAESESEQLirevESWQKRFEARQQEEARYSAMI 719
Cdd:PRK03918  664 LREEYLELSRE-LAGLRAELEELEKRRE-EIKKTLEKLKEELEEREKAKKELEKL----EKALERVEELREKVKKYKALL 737


                  ...
gi 344240178  720 QEQ 722
Cdd:PRK03918  738 KER 740
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 99-701 1.69e-14

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 80.40  E-value: 1.69e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    99 ILQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTekdaqiamMQQRIDHLALLNEKQAASSQESReleelrgKNES 178
Cdd:TIGR00618  312 IHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQT--------LHSQEIHIRDAHEVATSIREISC-------QQHT 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   179 LTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAfndltEEHNKASQEWAE-KQTHLEKEL 257
Cdd:TIGR00618  377 LTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHA-----KKQQELQQRYAElCAAAITCTA 451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   258 STALQDKKYLEEKNEILQGKLSQLEERaSQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQ 337
Cdd:TIGR00618  452 QCEKLEKIHLQESAQSLKEREQQLQTK-EQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRM 530

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   338 EAQLLAERGHFEEEKQQLASLIADLQsSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAK 417
Cdd:TIGR00618  531 QRGEQTYAQLETSEEDVYHQLTSERK-QRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDM 609

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   418 KEQAQMVQSLQEQEQAA-QGLRQQVEQLSsslklKEQQLEEAAKDQEA---ARQDHAQQLAIVAEAREASLRERDAARQQ 493
Cdd:TIGR00618  610 LACEQHALLRKLQPEQDlQDVRLHLQQCS-----QELALKLTALHALQltlTQERVREHALSIRVLPKELLASRQLALQK 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   494 LETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHV-TELEAQLKAEQ 572
Cdd:TIGR00618  685 MQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQArTVLKARTEAHF 764

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   573 QKVAEREKVMQEKAQLQEqllaLEETLQITKGSLEEEKHRTADALAEQQrcvTKMEAESRSLMEQREQEQKALEQEKagr 652
Cdd:TIGR00618  765 NNNEEVTAALQTGAELSH----LAAEIQFFNRLREEDTHLLKTLEAEIG---QEIPSDEDILNLQCETLVQEEEQFL--- 834

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178   653 kglearlQQLEE--ARQAETEALRRELAEATASQHRAESESEQLIREVESW 701
Cdd:TIGR00618  835 -------SRLEEksATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKL 878
growth_prot_Scy NF041483
polarized growth protein Scy;
317-1533 2.24e-12

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 73.32  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  317 AAHNTQLQARIETLDCERSQQEAQLLAERghfeeeKQQLASLIADlqssisNLSQAkEELEQASQAQGAQLTAQVASlta 396
Cdd:NF041483  111 AEHQARLQAELHTEAVQRRQQLDQELAER------RQTVESHVNE------NVAWA-EQLRARTESQARRLLDESRA--- 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  397 lnttlqqQQDQELASLKEQAKKEQAQMVQSLQEQEQAAqglRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLaiv 476
Cdd:NF041483  175 -------EAEQALAAARAEAERLAEEARQRLGSEAESA---RAEAEAILRRARKDAERLLNAASTQAQEATDHAEQL--- 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  477 aeaREASLRERDAARQQLETLEKekaAKLESLQQQLEAANEARDSVQTSVTQVQQEKAelsqkiEELHACIEAAHQEQRQ 556
Cdd:NF041483  242 ---RSSTAAESDQARRQAAELSR---AAEQRMQEAEEALREARAEAEKVVAEAKEAAA------KQLASAESANEQRTRT 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  557 AQAHVTEL--EAQLKAEQQKvAEREKVMQEKAQLQEQLLAlEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSL 634
Cdd:NF041483  310 AKEEIARLvgEATKEAEALK-AEAEQALADARAEAEKLVA-EAAEKARTVAAEDTAAQLAKAARTAEEVLTKASEDAKAT 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  635 MEQREQEQKALEQE---KAGRKGLEARLQ--QLEEARQAETEALRRELAEATASQHRAESESEQLIREV--ESWQKRFEA 707
Cdd:NF041483  388 TRAAAEEAERIRREaeaEADRLRGEAADQaeQLKGAAKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAvaEGERIRGEA 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  708 R-----QQEEARYSAmiQEQLAALKGDHEKAGQEAQEEAVEVHGEGqIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLA 782
Cdd:NF041483  468 RreavqQIEEAARTA--EELLTKAKADADELRSTATAESERVRTEA-IERATTLRRQAEETLERTRAEAERLRAEAEEQA 544

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  783 DDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESnwLEEQRGgpfSSPQAALKAMEQEAEQMGS 862
Cdd:NF041483  545 EEVRAAAERAARELREETERAIAARQAEAAEELTRLHTEAEERLTAAEEA--LADARA---EAERIRREAAEETERLRTE 619

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  863 ELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAE-LEVRLQNTLNEQRVEFAALQEALDHALTE 941
Cdd:NF041483  620 AAERIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRLRSEAAAEAErLKSEAQESADRVRAEAAAAAERVGTEAAE 699

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  942 KEGKDQELAKLRGQEAaqrtelkelQQTLEHLKTQlVKKEKEQHPAGStggEE--ASA----PEAQLETVRKTEAPDPEV 1015
Cdd:NF041483  700 ALAAAQEEAARRRREA---------EETLGSARAE-ADQERERAREQS---EEllASArkrvEEAQAEAQRLVEEADRRA 766

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1016 EALraeVSKLEQQCQQQKQQVEGLTHSLESERAS-RAEQDKALETLQGQLEEKTQELghsqAASASAQREltalhakaqd 1094
Cdd:NF041483  767 TEL---VSAAEQTAQQVRDSVAGLQEQAEEEIAGlRSAAEHAAERTRTEAQEEADRV----RSDAYAERE---------- 829

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1095 hsKAEEEwkaqVARGQQEAERKSSLISSLEEevsilnRQVLEKEGESkelKRLVVAESEKSQkleeRLRLLQVETASSSA 1174
Cdd:NF041483  830 --RASED----ANRLRREAQEETEAAKALAE------RTVSEAIAEA---ERLRSDASEYAQ----RVRTEASDTLASAE 890

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1175 RAAERSSA-LREEVQSLREEVEKQrviSENLRQELTSQAER----AEELGQELKAWQEKFFQKEQALSALQLEHTSTQAL 1249
Cdd:NF041483  891 QDAARTRAdAREDANRIRSDAAAQ---ADRLIGEATSEAERltaeARAEAERLRDEARAEAERVRADAAAQAEQLIAEAT 967

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1250 V-SELLPAKhlcqqlqaeqaaaekrHREEIEQSKQAAGGLRAELMRAqrelgelgplrqkVAEQERAAQQLRAEKASYAE 1328
Cdd:NF041483  968 GeAERLRAE----------------AAETVGSAQQHAERIRTEAERV-------------KAEAAAEAERLRTEAREEAD 1018

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1329 QLsmLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEM----RQEAQSTTRELEV---- 1400
Cdd:NF041483 1019 RT--LDEARKDANKRRSEAAEQADTLITEAAAEADQLTAKAQEEALRTTTEAEAQADTMvgaaRKEAERIVAEATVegns 1096

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1401 -----MTAKYE---GAKVKVLEERQRFQEERQKLTAQVEELSKKLT-EYDQASKVQQQK----LKAFQAQGGESQQEVQR 1467
Cdd:NF041483 1097 lvekaRTDADEllvGARRDATAIRERAEELRDRITGEIEELHERARrESAEQMKSAGERcdalVKAAEEQLAEAEAKAKE 1176

                        1210      1220      1230      1240      1250      1260      1270
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178 1468 LQAQLNELQTQLS----------QKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAER 1533
Cdd:NF041483 1177 LVSDANSEASKVRiaavkkaeglLKEAEQKKAELVREAEKIKAEAEAEAKRTVEEGKRELDVLVRRREDINAEISR 1252
growth_prot_Scy NF041483
polarized growth protein Scy;
320-1418 1.92e-11

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 70.24  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  320 NTQLQARIETLDCERSQQEAQLLAERgHFEEEKQQLASLIADL-QSSISNLSQAKEELEQASQAQGAQLTAQVASLTALN 398
Cdd:NF041483   80 NAQIQADQLRADAERELRDARAQTQR-ILQEHAEHQARLQAELhTEAVQRRQQLDQELAERRQTVESHVNENVAWAEQLR 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  399 TTLQQQQ-----------DQELASLKEQAKKEQAQMVQSLQEQEQAAqglRQQVEQLSSSLKLKEQQLEEAAKDQEAARQ 467
Cdd:NF041483  159 ARTESQArrlldesraeaEQALAAARAEAERLAEEARQRLGSEAESA---RAEAEAILRRARKDAERLLNAASTQAQEAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  468 DHAQQLaivaeaREASLRERDAARQQLETLEKekaAKLESLQQQLEAANEARDSVQTSVTQVQQEKAElsqkieELHACI 547
Cdd:NF041483  236 DHAEQL------RSSTAAESDQARRQAAELSR---AAEQRMQEAEEALREARAEAEKVVAEAKEAAAK------QLASAE 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  548 EAAHQEQRQAQAHVTEL--EAQLKAEQQKvAEREKVMQEKAQLQEQLLAlEETLQITKGSLEEEKHRTADALAEQQRCVT 625
Cdd:NF041483  301 SANEQRTRTAKEEIARLvgEATKEAEALK-AEAEQALADARAEAEKLVA-EAAEKARTVAAEDTAAQLAKAARTAEEVLT 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 KMEAESRSLMEQREQEQKALEQE---KAGRKGLEARLQ--QLEEARQAETEALRRELAEATASQHRAESESEQLIREV-- 698
Cdd:NF041483  379 KASEDAKATTRAAAEEAERIRREaeaEADRLRGEAADQaeQLKGAAKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAva 458

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  699 ESWQKRFEAR-----QQEEARYSAmiQEQLAALKGDHEKAGQEAQEEAVEVHGEGqIGEQQSPLAQLHTTLARALQQVKE 773
Cdd:NF041483  459 EGERIRGEARreavqQIEEAARTA--EELLTKAKADADELRSTATAESERVRTEA-IERATTLRRQAEETLERTRAEAER 535

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  774 KEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESnwLEEQRGgpfSSPQAALKAM 853
Cdd:NF041483  536 LRAEAEEQAEEVRAAAERAARELREETERAIAARQAEAAEELTRLHTEAEERLTAAEEA--LADARA---EAERIRREAA 610

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  854 EQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAE-LEVRLQNTLNEQRVEFAALQ 932
Cdd:NF041483  611 EETERLRTEAAERIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRLRSEAAAEAErLKSEAQESADRVRAEAAAAA 690

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  933 EALDHALTEKEGKDQELAKLRGQEA-----AQRTELKE-----LQQTLEHLKTQLVKKEKEQ-------HPAGSTGGEEA 995
Cdd:NF041483  691 ERVGTEAAEALAAAQEEAARRRREAeetlgSARAEADQereraREQSEELLASARKRVEEAQaeaqrlvEEADRRATELV 770

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  996 SAPEAQLETVRKT-----EAPDPEVEALR------AEVSKLEQQCQQQKQQVEGLThslESERAS------RAEQDKALE 1058
Cdd:NF041483  771 SAAEQTAQQVRDSvaglqEQAEEEIAGLRsaaehaAERTRTEAQEEADRVRSDAYA---ERERASedanrlRREAQEETE 847

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1059 TLQGqLEEKTQELGHSQA------ASASAQRELT----ALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVS 1128
Cdd:NF041483  848 AAKA-LAERTVSEAIAEAerlrsdASEYAQRVRTeasdTLASAEQDAARTRADAREDANRIRSDAAAQADRLIGEATSEA 926

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1129 ILNRQVLEKEGE------SKELKRLVVAESEKSQKL-------EERLRLLQVETASSSARAAERssaLREEVQSLREEVE 1195
Cdd:NF041483  927 ERLTAEARAEAErlrdeaRAEAERVRADAAAQAEQLiaeatgeAERLRAEAAETVGSAQQHAER---IRTEAERVKAEAA 1003

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1196 KQrviSENLRQELTSQAERAEELGQELK-------AWQEKFFQKEQALSALQLEHTSTQalvsELLPAKHLCQQLQAEQA 1268
Cdd:NF041483 1004 AE---AERLRTEAREEADRTLDEARKDAnkrrseaAEQADTLITEAAAEADQLTAKAQE----EALRTTTEAEAQADTMV 1076

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1269 AAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAaQQLRAEKASYAEQLSmlKKAHGLLAEENRGLG 1348
Cdd:NF041483 1077 GAARKEAERIVAEATVEGNSLVEKARTDADELLVGARRDATAIRERA-EELRDRITGEIEELH--ERARRESAEQMKSAG 1153

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1349 ERANLGRQFLEVELDQAREKYVQ------------ELAAVRTdAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEER 1416
Cdd:NF041483 1154 ERCDALVKAAEEQLAEAEAKAKElvsdanseaskvRIAAVKK-AEGLLKEAEQKKAELVREAEKIKAEAEAEAKRTVEEG 1232


                  ..
gi 344240178 1417 QR 1418
Cdd:NF041483 1233 KR 1234
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2231-2376 1.44e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2231 LLGAIQEGQLGIVQQLLESGSDAsgggplrnveESEDRSWREALNLAIRLGHEAITDVLL---ANIKFDFRQIHEALLVA 2307
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADV----------NARDKDGETPLHLAAYNGNLEIVKLLLeagADVNAQDNDGNTPLHLA 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178 2308 VDTNQPAVVRCLLarlerEKGRKVDTKSfslaffdssidgsrfAPGVTPLTLACQKDLYEIAQLLMDQG 2376
Cdd:COG0666   161 AANGNLEIVKLLL-----EAGADVNARD---------------NDGETPLHLAAENGHLEIVKLLLEAG 209
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 297-646 1.77e-09

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 64.09  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  297 GEVLGDALQLETLKQEAAKLAAHNTQLQARIETL-DCERSQQEAQLLaerghfEEEKQQLASLIADLQSSISNLSQAKee 375
Cdd:NF012221 1528 GYILDNVVATSESSQQADAVSKHAKQDDAAQNALaDKERAEADRQRL------EQEKQQQLAAISGSQSQLESTDQNA-- 1599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  376 LEQASQAQGAQLTAQVASLTALNTTLQQQQDQelasLKEQAkkeQAQMVQSLQEQEQAAQGLRQQV-EQLSSSLKLKEQQ 454
Cdd:NF012221 1600 LETNGQAQRDAILEESRAVTKELTTLAQGLDA----LDSQA---TYAGESGDQWRNPFAGGLLDRVqEQLDDAKKISGKQ 1672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  455 LEEAakdqeaaRQDHAQQLAIVAEAreaslrerdaarqqletLEKEKAAKLESLQQQLEAaneaRDSVQTSVTQVQQEKA 534
Cdd:NF012221 1673 LADA-------KQRHVDNQQKVKDA-----------------VAKSEAGVAQGEQNQANA----EQDIDDAKADAEKRKD 1724

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  535 ElsqkieelhACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQ--EQLLALEETLQITKGSLEEEKHR 612
Cdd:NF012221 1725 D---------ALAKQNEAQQAESDANAAANDAQSRGEQDASAAENKANQAQADAKgaKQDESDKPNRQGAAGSGLSGKAY 1795

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 344240178  613 TADALAEQQ---RCVTKMEAESRSLMEQREQEQKALE 646
Cdd:NF012221 1796 SVEGVAEPGshiNPDSPAAADGRFSEGLTEQEQEALE 1832
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 2672-2791 4.39e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 62.34  E-value: 4.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2672 LGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLNNIYVPyQETEKLGNFNE-------TFQfLFWTMFGMEEHTVVDMP 2743
Cdd:cd22192   447 LGPFTIMIQKIIfGDLMKFCWLMFVVILGFSSAFYMIFQT-EDPDSLGHFYDfpmtlfsTFE-LFLGLIDGPANYTVDLP 524

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 344240178 2744 QFLvpefvgRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWK 2791
Cdd:cd22192   525 FMY------KVLYTAFAVIAYLLMLNLLIAMMGDTHWRVAHERDELWR 566
HkD_NuMA cd22224
Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also ...
 1-44 9.24e-08

Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also called nuclear mitotic apparatus protein 1, or nuclear matrix protein-22 (NMP-22), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles, and the alignment and segregation of chromosomes during mitotic cell division. The model corresponds to the N-terminal conserved globular Hook domain of NuMA, which folds as a variant of the helical calponin homology (CH) domain. It directly binds dynein light intermediate chains LIC1 and LIC2 through a conserved hydrophobic patch shared among other Hook adaptors.


Pssm-ID: 411795  Cd Length: 148  Bit Score: 53.73  E-value: 9.24e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 344240178    1 MSSRNPrdWEQFEYRIQAELAVILKFMLDHEDSLNLIEDLENFL 44
Cdd:cd22224   106 MNNNLT--LEKLDYKTELELASILRFVLDNEDGLYLSEGLDKFL 147
growth_prot_Scy NF041483
polarized growth protein Scy;
548-1550 3.43e-06

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 53.29  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  548 EAAHQEQRQAQAHvTELEAQLKAE--QQKVAEREKVMQEkaqlqeqllaLEETLQITKGSLEEEKhrtadALAEQQRCVT 625
Cdd:NF041483   98 DARAQTQRILQEH-AEHQARLQAElhTEAVQRRQQLDQE----------LAERRQTVESHVNENV-----AWAEQLRART 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 kmEAESRSLMEQREQEQkalEQEKAGRKGLEARLQqlEEARQ---AETEALRrelAEATASQHRAESESEQLIREVESwq 702
Cdd:NF041483  162 --ESQARRLLDESRAEA---EQALAAARAEAERLA--EEARQrlgSEAESAR---AEAEAILRRARKDAERLLNAAST-- 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  703 krfearQQEEARYSAmiqEQL-AALKGDHEKAGQEAQEeaVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKL 781
Cdd:NF041483  230 ------QAQEATDHA---EQLrSSTAAESDQARRQAAE--LSRAAEQRMQEAEEALREARAEAEKVVAEAKEAAAKQLAS 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  782 ADdltTLQEKMASTSKvaACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESNWLEEqrggpfSSPQAALKAMEQEAEQMG 861
Cdd:NF041483  299 AE---SANEQRTRTAK--EEIARLVGEATKEAEALKAEAEQALADARAEAEKLVAE------AAEKARTVAAEDTAAQLA 367

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  862 SELERLRVALMKSQGQQQEERGQQEREVARLTRErSQAQADLAQEKAAKA--ELEVRLQNTLNEQRVEFAALQEALDHAL 939
Cdd:NF041483  368 KAARTAEEVLTKASEDAKATTRAAAEEAERIRRE-AEAEADRLRGEAADQaeQLKGAAKDDTKEYRAKTVELQEEARRLR 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  940 TEKEGKDQELA----KLRGQ---EAAQRTElkELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPD 1012
Cdd:NF041483  447 GEAEQLRAEAVaegeRIRGEarrEAVQQIE--EAARTAEELLTKAKADADELRSTATAESERVRTEAIERATTLRRQAEE 524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1013 P------EVEALRAEVSKLEQQCQQQKQQVEGLTHSlESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELT 1086
Cdd:NF041483  525 TlertraEAERLRAEAEEQAEEVRAAAERAARELRE-ETERAIAARQAEAAEELTRLHTEAEERLTAAEEALADARAEAE 603

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1087 ALHAKAQDHS-----KAEEEWKAQVARGQQEAERKSSlissleEEVSILNRQVLEKEGESKELKRLVVAESEK----SQK 1157
Cdd:NF041483  604 RIRREAAEETerlrtEAAERIRTLQAQAEQEAERLRT------EAAADASAARAEGENVAVRLRSEAAAEAERlkseAQE 677

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1158 LEERLRllqVETASSSAR----AAERSSALREEVQSLREEVEKqrvISENLRQELTSQAERAEELGQELKAWQEKFFQKE 1233
Cdd:NF041483  678 SADRVR---AEAAAAAERvgteAAEALAAAQEEAARRRREAEE---TLGSARAEADQERERAREQSEELLASARKRVEEA 751

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1234 QALSALQLEHTSTQAlvSELLPAkhlcqqlqaeQAAAEKRHREEI----EQSKQAAGGLR-AELMRAQRELGELGPLRQK 1308
Cdd:NF041483  752 QAEAQRLVEEADRRA--TELVSA----------AEQTAQQVRDSVaglqEQAEEEIAGLRsAAEHAAERTRTEAQEEADR 819

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1309 V-----AEQERA---AQQLRAEKASYAEQL-SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTD 1379
Cdd:NF041483  820 VrsdayAERERAsedANRLRREAQEETEAAkALAERTVSEAIAEAERLRSDASEYAQRVRTEASDTLASAEQDAARTRAD 899

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1380 AETHLAEMRQEAQS--------TTRELEVMTAKYEGAKVKVLEE-RQRFQEERQKLTAQVEELSKKLTEydqaskvQQQK 1450
Cdd:NF041483  900 AREDANRIRSDAAAqadrligeATSEAERLTAEARAEAERLRDEaRAEAERVRADAAAQAEQLIAEATG-------EAER 972

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1451 LKAFQAQG-GESQQEVQRLQAqlnELQTQLSQKEQAAEHYK--LQMEKAKTHYDAKKQQNQELQDQLrdlEQLQKENKEL 1527
Cdd:NF041483  973 LRAEAAETvGSAQQHAERIRT---EAERVKAEAAAEAERLRteAREEADRTLDEARKDANKRRSEAA---EQADTLITEA 1046

                        1050      1060
                  ....*....|....*....|....
gi 344240178 1528 RAEAERLGRELQQAGLK-TKEAEQ 1550
Cdd:NF041483 1047 AAEADQLTAKAQEEALRtTTEAEA 1070
growth_prot_Scy NF041483
polarized growth protein Scy;
220-800 8.30e-06

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 51.75  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  220 EFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKElstALQDKKYLEEKNEILQGklsQLEERASQQCESPAQEKGEV 299
Cdd:NF041483  412 EAADQAEQLKGAAKDDTKEYRAKTVELQEEARRLRGE---AEQLRAEAVAEGERIRG---EARREAVQQIEEAARTAEEL 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  300 LGDAlqletlKQEAAKLAAHNTQLQARIETLDCERS-----QQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQA-K 373
Cdd:NF041483  486 LTKA------KADADELRSTATAESERVRTEAIERAttlrrQAEETLERTRAEAERLRAEAEEQAEEVRAAAERAARElR 559

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  374 EELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQA---KKEQAQMVQSLQ-EQEQAAQGLRQQVEQLSSSLK 449
Cdd:NF041483  560 EETERAIAARQAEAAEELTRLHTEAEERLTAAEEALADARAEAeriRREAAEETERLRtEAAERIRTLQAQAEQEAERLR 639

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  450 lkeqqlEEAAKDQEAARQD------------HAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQqlEAAN- 516
Cdd:NF041483  640 ------TEAAADASAARAEgenvavrlrseaAAEAERLKSEAQESADRVRAEAAAAAERVGTEAAEALAAAQE--EAARr 711

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  517 --EARDSVQTSVTQVQQEKAELSQKIEELHACI-----EAAHQEQR---QAQAHVTELEAqlKAEQQKVAEREKVMQEKA 586
Cdd:NF041483  712 rrEAEETLGSARAEADQERERAREQSEELLASArkrveEAQAEAQRlveEADRRATELVS--AAEQTAQQVRDSVAGLQE 789

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  587 QLQEQLLAL----EETLQITKGSLEEEKHRT-ADALAEQQRCvtkmeAESRSLMEQREQEQKALEQEKAGRKGLEA---- 657
Cdd:NF041483  790 QAEEEIAGLrsaaEHAAERTRTEAQEEADRVrSDAYAERERA-----SEDANRLRREAQEETEAAKALAERTVSEAiaea 864

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  658 ---RLQQLEEARQAETEAL-RRELAEATASQHRAE-------------SESEQLIREVESWQKRFEARQQEEArysamiQ 720
Cdd:NF041483  865 erlRSDASEYAQRVRTEASdTLASAEQDAARTRADaredanrirsdaaAQADRLIGEATSEAERLTAEARAEA------E 938

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  721 EQLAALKGDHEKAGQEAQEEAVEVHGEGqIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAA 800
Cdd:NF041483  939 RLRDEARAEAERVRADAAAQAEQLIAEA-TGEAERLRAEAAETVGSAQQHAERIRTEAERVKAEAAAEAERLRTEAREEA 1017
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1419-1588 4.69e-05

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 48.13  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1419 FQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQmekakt 1498
Cdd:cd22656   112 LEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIARKEIKDLQ------ 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1499 hyDAKKQQNQELQDQLRD-LEQLQKENKELRAEaerlgrelqqagLKTKEAEQAC-RHLSAQVRSLEAQVAHAdqqLRDL 1576
Cdd:cd22656   186 --KELEKLNEEYAAKLKAkIDELKALIADDEAK------------LAAALRLIADlTAADTDLDNLLALIGPA---IPAL 248

                         170
                  ....*....|..
gi 344240178 1577 GKFQVATDALKS 1588
Cdd:cd22656   249 EKLQGAWQAIAT 260
antiphage_ZorA_2 NF033915
anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel ...
 286-462 5.24e-05

anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.


Pssm-ID: 411476 [Multi-domain]  Cd Length: 383  Bit Score: 48.61  E-value: 5.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  286 SQQCESPAQEKGEVLGDALQlETLKQ-----EAAKLAAHNTQLQARIETLDCERSQQEAQLLaerghfeeekQQLASLIA 360
Cdd:NF033915  215 SKESKEALQELHERIGDRLQ-ESLNGmseamQTALTDALNNIMAPAIQTLVSTTSQQSTQVL----------ESLVGNFM 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  361 DLQSSISNlsQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQ 440
Cdd:NF033915  284 DGMTSAGR--EQGLQMQQAAADVNAAVSGMSERLNQLFNSLSEQQGRQMERAQQQSSTFETQLQRLSGSANERQAQLEQR 361

                         170       180
                  ....*....|....*....|..
gi 344240178  441 VEQLSSSLKLKEQQLEEAAKDQ 462
Cdd:NF033915  362 FEELMSGLTEQLQTQLGAAQQR 383
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1395-1540 1.09e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 46.93  E-value: 1.09e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   1395 TRELEVMTAKYEgakvKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQK----LKAFQAQGGESQQEVQRLQA 1470
Cdd:smart00787  150 DENLEGLKEDYK----LLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCdpteLDRAKEKLKKLLQEIMIKVK 225

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178   1471 QLNELQTQLSQKEQAAEhyklqmekakthydAKKQQNQELQDQLRDLEQLQKENKELRA-EAERLGRELQQ 1540
Cdd:smart00787  226 KLEELEEELQELESKIE--------------DLTNKKSELNTEIAEAEKKLEQCRGFTFkEIEKLKEQLKL 282
HpsJ_fam NF038305
HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the ...
 397-512 1.79e-04

HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the biosynthesis or secretion of an extracellular polysaccharide shared by many Cyanobacteria.


Pssm-ID: 468465 [Multi-domain]  Cd Length: 230  Bit Score: 45.65  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  397 LNTTlQQQQDQELASLKEQAKKEQAQmVQSLQEQEQAAQGlRQQVEQLSSSLKLKEQQLEEAAKDQEaARQDHAQQLAIV 476
Cdd:NF038305   99 LNNT-RRLSTQALQQINQQAGQQETQ-LQQQLNQLQAQTS-PQQLNQLLKSEQKQGQALASGQLPEE-QKEQLQQFKSNP 174

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 344240178  477 AEAREASLRERDAARQQLETLEKEkaAKLESLQQQL 512
Cdd:NF038305  175 QALDKFLAQQLTQIRTQAEEAEKQ--ARLEALKSSL 208
F-BAR_FCHO2 cd07673
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein; ...
 407-590 3.91e-04

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. The specific function of FCH domain Only 2 (FCHO2) is still unknown. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCHO1 and endophilin interacting protein 1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153357 [Multi-domain]  Cd Length: 269  Bit Score: 45.05  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  407 QELasLKEQAKKEQAQMVQSLQEQEQAAQGLR--QQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQlaivAEAREASL 484
Cdd:cd07673    91 QEL--IKEVQKYGEEQVKSHKKTKEEVAGTLEavQNIQSITQALQKSKENYNAKCLEQERLKKEGATQ----REIEKAAV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  485 RERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTel 564
Cdd:cd07673   165 KSKKATESYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIRIKEIIGSYSNSVKEIHIQIGQVHEEFINNMANTT-- 242

                         170       180
                  ....*....|....*....|....*.
gi 344240178  565 eaqLKAEQQKVAEREKVMQEKAQLQE 590
Cdd:cd07673   243 ---VESLIQKFAESKGTGKERPGPIE 265
HpsJ_fam NF038305
HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the ...
 320-449 2.61e-03

HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the biosynthesis or secretion of an extracellular polysaccharide shared by many Cyanobacteria.


Pssm-ID: 468465 [Multi-domain]  Cd Length: 230  Bit Score: 42.19  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  320 NTQLQARIETldcERSQQEAQLlaerghfeeeKQQLASLIAdlQSSISNLSQ-AKEELEQASQAQGAQLTAQVASLtaln 398
Cdd:NF038305  106 STQALQQINQ---QAGQQETQL----------QQQLNQLQA--QTSPQQLNQlLKSEQKQGQALASGQLPEEQKEQ---- 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  399 ttLQQQQDQELAsLKEQAKKEQAQMVQSLQEQEQaaqglRQQVEQLSSSLK 449
Cdd:NF038305  167 --LQQFKSNPQA-LDKFLAQQLTQIRTQAEEAEK-----QARLEALKSSLR 209
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 486-580 2.63e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 40.64  E-value: 2.63e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    486 ERDAARQQLETLEKEKAAKLESLQQQLEAANEA--RDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTE 563
Cdd:smart00935   15 AGKAAQKQLEKEFKKRQAELEKLEKELQKLKEKlqKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQ 94

                            90
                    ....*....|....*...
gi 344240178    564 -LEAQLKAEQQKVAEREK 580
Cdd:smart00935   95 kILDKINKAIKEVAKKKG 112
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 321-535 4.02e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.97  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  321 TQLQARIETLDCERSQQEaqllaerghFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTT 400
Cdd:cd22656    94 AEILELIDDLADATDDEE---------LEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  401 LQQQQDQELASLKEQAKKE-QAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEA 479
Cdd:cd22656   165 LKDLLTDEGGAIARKEIKDlQKELEKLNEEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPA 244

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  480 REAslrerdaarqqLETLEK---EKAAKLESLQQQLEaaNEARDSVQTSVTQVQQEKAE 535
Cdd:cd22656   245 IPA-----------LEKLQGawqAIATDLDSLKDLLE--DDISKIPAAILAKLELEKAI 290
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 335-722 4.05e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.69  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  335 SQQEAQLLAERGHFEEEKQQLASLIADLQSSIsnlsqakEELEQASQAQGAQLTAQVASLTALNTTLqqqqdqELASLKE 414
Cdd:NF033838  117 SKTKKELDAAFEQFKKDTLEPGKKVAEATKKV-------EEAEKKAKDQKEEDRRNYPTNTYKTLEL------EIAESDV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  415 QAKKEQAQMVQSlQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDhaqqlaivaEAREASLRERDAARQQL 494
Cdd:NF033838  184 EVKKAELELVKE-EAKEPRDEEKIKQAKAKVESKKAEATRLEKIKTDREKAEEE---------AKRRADAKLKEAVEKNV 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  495 ETLEKEKA---AKLESLQQQlEAANEARDSVQTSVTQVQQEK-AELSQKieelhacieaahQEQRQAQAHVTELEAQLKA 570
Cdd:NF033838  254 ATSEQDKPkrrAKRGVLGEP-ATPDKKENDAKSSDSSVGEETlPSPSLK------------PEKKVAEAEKKVEEAKKKA 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  571 EQQKVAERE------------KVMQEKAQLQEQLLAL--EEtlqiTKGSLEEEKHRTADALAEQQRC-VTKMEAESRSLM 635
Cdd:NF033838  321 KDQKEEDRRnyptntyktlelEIAESDVKVKEAELELvkEE----AKEPRNEEKIKQAKAKVESKKAeATRLEKIKTDRK 396

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  636 EQREQ-EQKALEQEKAGRKGLEArlQQLEEARQAETEALRrelAEATASQHRAESESEQLIREVeswqkrfEARQQEEaR 714
Cdd:NF033838  397 KAEEEaKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPK---PEKPAEQPKAEKPADQQAEED-------YARRSEE-E 463


                  ....*...
gi 344240178  715 YSAMIQEQ 722
Cdd:NF033838  464 YNRLTQQQ 471
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 339-501 6.79e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.54  E-value: 6.79e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    339 AQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQ----------ASQAQGAQLTAQVASLTALNTTLQQQQDQE 408
Cdd:smart00787  126 ARLEAKKMWYEWRMKLLEGLKEGLDENLEGLKEDYKLLMKelellnsikpKLRDRKDALEEELRQLKQLEDELEDCDPTE 205

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    409 LASLKEQAKKEQAQMVQSLQEQEQaaqgLRQQVEQLssslklkEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERD 488
Cdd:smart00787  206 LDRAKEKLKKLLQEIMIKVKKLEE----LEEELQEL-------ESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIE 274

                           170
                    ....*....|...
gi 344240178    489 AARQQLETLEKEK 501
Cdd:smart00787  275 KLKEQLKLLQSLT 287
 
Name Accession Description Interval E-value
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 2230-2897 1.10e-116

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 389.83  E-value: 1.10e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2230 TLLGAIQEGQLGIVQQLLEsgsdasggGPLRNVEESEDRSWREAL-NLAIRLGHEAITDVLLaNIKFDFRQIHEALLVAV 2308
Cdd:TIGR00870   20 AFLPAAERGDLASVYRDLE--------EPKKLNINCPDRLGRSALfVAAIENENLELTELLL-NLSCRGAVGDTLLHAIS 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2309 DTNQPAVVRCLLARLEREKgrkvDTKSFSLAFfdsSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIarphPVSCA 2388
Cdd:TIGR00870   91 LEYVDAVEAILLHLLAAFR----KSGPLELAN---DQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASV----PARAC 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2389 CLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASED--AMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFEL 2466
Cdd:TIGR00870  160 GDFFVKSQGVDSFYHGESPLNAAACLGSPSIVALLSEDpaDILTADSLGNTLLHLLVMENEFKAEYEELSCQMYNFALSL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2467 LGMCRNQSEVTAVLNDLGEDSETepeseglgQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGST 2546
Cdd:TIGR00870  240 LDKLRDSKELEVILNHQGLTPLK--------LAAKEGRIVLFRLKLAIKYKQKKFVAWPNGQQLLSLYWLEELDGWRRKQ 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2547 TIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGHLLKIPVLKFLLHSASYLWFLI--------------------------- 2599
Cdd:TIGR00870  312 SVLELIVVFVIGLKFPELSDMYLIAPLSRLGQFKWKPFIKFIFHSASYLYFLYliiftsvayyrptrtdlrvtglqqtpl 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2600 ----------FLLGESLVMETQLSTFKGRSQ-SVWETSLHMIWV------------------TERSEWRTEDPQFLAEVL 2650
Cdd:TIGR00870  392 emlivtwvdgLRLGEEKLIWLGGIFEYIHQLwNILDFGMNSFYLatfldrpfailfvtqaflVLREHWLRFDPTLIEEAL 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2651 FAVTSMLSFTRLAYILPAHESLGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLNNIYVPYQETEKLGNFN-------- 2721
Cdd:TIGR00870  472 FAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMIlGDILRFLFIYAVVLFGFACGLNQLYQYYDELKLNECSNpharscek 551

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2722 ---------ETFQFLFWTMFGMEEhtVVDMPQFLVpEFVGRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKF 2792
Cdd:TIGR00870  552 qgnaystlfETSQELFWAIIGLGD--LLANEHKFT-EFVGLLLFGAYNVIMYILLLNMLIAMMGNTYQLIADDADEEWKF 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2793 ARSKLYLSYFREGLTLPVPFNILPSPKAAFYLVRRIFWFLCCCSSCCKAKKSDYppiptFTNPGARARPGEGERGSYRLR 2872
Cdd:TIGR00870  629 QRAKLWMSYEREGGTCPPPFNIIPGPKSFVGLFKRIEKHDGKKRQRWCRRVEEV-----NWTTWERKAETLIEDGLHYQR 703

                          730       740
                   ....*....|....*....|....*..
gi 344240178  2873 VVKALVQRYI--ETARREFEETRRKDL 2897
Cdd:TIGR00870  704 VMKRLIKRYVlaEQRPRDDEGTTEEET 730
XRCC1_N pfam01834
XRCC1 N terminal domain;
1925-2059 5.51e-59

XRCC1 N terminal domain;


Pssm-ID: 460356  Cd Length: 148  Bit Score: 200.54  E-value: 5.51e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1925 DPKYPVENLLNPDNHRgPWLSCPRDkSGQLKVELQLERVVPISYIDVGNCGCAFLQIDVGRSSWPLDKPFVTLLPATMLM 2004
Cdd:pfam01834   16 DPVHPAENLLKSDTYR-KWKCAKPG-EKQASVELQLERASQITSIDIGNEGSAFVEVLVGRSSWPDDQDFEVLLVTSSFM 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  2005 SLADSKEGKNRSGVRMFKNDDFLTPASGESWDRLRLLCSQPFTRHQSFGLAFVQV 2059
Cdd:pfam01834   94 TPSESKNGTNRNRVRMFGKDKLNSSAAEEKWDRVKIVCTQPFNKTVQYGLSFIKF 148
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 437-1026 7.41e-33

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 140.07  E-value: 7.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  437 LRQQVEqlssslKLKEQ--QLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEA 514
Cdd:COG1196   198 LERQLE------PLERQaeKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  515 ANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLA 594
Cdd:COG1196   272 LRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE---EELEELEEELEE 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  595 LEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQR------EQEQKALEQEKAGRKGLEARLQQLEEARQA 668
Cdd:COG1196   349 AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALraaaelAAQLEELEEAEEALLERLERLEEELEELEE 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  669 ETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVHGEG 748
Cdd:COG1196   429 ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLE 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  749 QIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLvLKAGEQQEMTSLELLKEPPGAG 828
Cdd:COG1196   509 GVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY-LKAAKAGRATFLPLDKIRARAA 587

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  829 NKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKA 908
Cdd:COG1196   588 LAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSR 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  909 AKAELEVRlqntlneqrvefAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAG 988
Cdd:COG1196   668 RELLAALL------------EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAERE 735

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 344240178  989 STGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLE 1026
Cdd:COG1196   736 ELLEELLEEEELLEEEALEELPEPPDLEELERELERLE 773
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 100-794 1.74e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 139.42  E-value: 1.74e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   100 LQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIdhLALLNEKQAASSQE---SRELEELRGKN 176
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL--YALANEISRLEQQKqilRERLANLERQL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   177 ESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEkqthLEKE 256
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ----LELQ 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   257 LSTALQDKKYLEEKNEILQGKLSQLEERASQQceSPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQ 336
Cdd:TIGR02168  395 IASLNNEIERLEARLERLEDRRERLQQEIEEL--LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEE 472

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   337 QEAQLLAERGHFEEEKQQLASLiADLQSSISNLSQAKEELEQAsQAQGAQLTAQVASL--------TALNTTLQQQQDQE 408
Cdd:TIGR02168  473 AEQALDAAERELAQLQARLDSL-ERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyeAAIEAALGGRLQAV 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   409 LASLKEQAKKEQAQMVQSL----------QEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAE 478
Cdd:TIGR02168  551 VVENLNAAKKAIAFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDD 630

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   479 AREA-SLRERDAARQQLETLEKEKAAKLESLqqqleaaNEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQA 557
Cdd:TIGR02168  631 LDNAlELAKKLRPGYRIVTLDGDLVRPGGVI-------TGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAEL 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   558 QAHVTELEAQLkaeqqkvaerEKVMQEKAQLQEQLLALEETLQItkgsLEEEKHRTADALAEQQRCVTKMEAESRSLMEQ 637
Cdd:TIGR02168  704 RKELEELEEEL----------EQLRKELEELSRQISALRKDLAR----LEAEVEQLEERIAQLSKELTELEAEIEELEER 769

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   638 REQEQKALEQEKAGRKGLEARLQQLEEARQAETE---ALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEAR 714
Cdd:TIGR02168  770 LEEAEEELAEAEAEIEELEAQIEQLKEELKALREaldELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEE 849

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   715 ysamIQEQLAALKGDHEKAGQ--EAQEEAVEVHGEgQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKM 792
Cdd:TIGR02168  850 ----LSEDIESLAAEIEELEEliEELESELEALLN-ERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL 924


                   ..
gi 344240178   793 AS 794
Cdd:TIGR02168  925 AQ 926
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 437-1220 7.31e-32

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 137.50  E-value: 7.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   437 LRQQVEqlssSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAAN 516
Cdd:TIGR02168  198 LERQLK----SLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   517 EARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKvaeREKVMQEKAQLQEQLLALE 596
Cdd:TIGR02168  274 LEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK---LDELAEELAELEEKLEELK 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   597 ETLQitkgSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEAR---QAETEAL 673
Cdd:TIGR02168  351 EELE----SLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRerlQQEIEEL 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   674 RRELAEATASQHRAesESEQLIREVESWQKRFEARQQEEARysamIQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQ 753
Cdd:TIGR02168  427 LKKLEEAELKELQA--ELEELEEELEELQEELERLEEALEE----LREELEEAEQALDAAERELAQLQARLDSLERLQEN 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   754 QSplaqlhtTLARALQQVKEKevrAQKLADDLTTLQEKMASTSKVAACLKTL-------VLKAGEQQEMTSLELLKEppg 826
Cdd:TIGR02168  501 LE-------GFSEGVKALLKN---QSGLSGILGVLSELISVDEGYEAAIEAAlggrlqaVVVENLNAAKKAIAFLKQ--- 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   827 AGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELErlRVALMKSQGQQQEERGQQEREVARLTrersQAQADLAQE 906
Cdd:TIGR02168  568 NELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLD----NALELAKKL 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   907 KAakAELEVRLQNTL-------NEQRVEFAALQEALDHALTEKEgkdQELAKLRGQEAAQRTELKELQQTLEHLKTQLVK 979
Cdd:TIGR02168  642 RP--GYRIVTLDGDLvrpggviTGGSAKTNSSILERRREIEELE---EKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   980 KEKEQHPAgstgGEEASAPEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALET 1059
Cdd:TIGR02168  717 LRKELEEL----SRQISALRKDLARLEA------EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1060 LQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEG 1139
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEE 866

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1140 ESKELKRLVVAESEKSQKLEERLRLL--QVETASSSARAAE-RSSALREEVQSLREEVEKQRVISENLRQELTSQAERAE 1216
Cdd:TIGR02168  867 LIEELESELEALLNERASLEEALALLrsELEELSEELRELEsKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS 946


                   ....
gi 344240178  1217 ELGQ 1220
Cdd:TIGR02168  947 EEYS 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 106-799 1.06e-31

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 136.72  E-value: 1.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   106 QMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHL-----ALLNEKQAASSQE---SRELEELRGKNE 177
Cdd:TIGR02168  240 ELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELqkelyALANEISRLEQQKqilRERLANLERQLE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   178 SLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEkqthLEKEL 257
Cdd:TIGR02168  320 ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ----LELQI 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   258 STALQDKKYLEEKNEILQGKLSQLEERASQQceSPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQ 337
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRRERLQQEIEEL--LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEA 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   338 EAQLLAERGHFEEEKQQLASLiADLQSSISNLSQAKEELEQAsQAQGAQLTAQVASL--------TALNTTLQQQQDQEL 409
Cdd:TIGR02168  474 EQALDAAERELAQLQARLDSL-ERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyeAAIEAALGGRLQAVV 551

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   410 ASLKEQAKKEQAQMVQSL----------QEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIV--- 476
Cdd:TIGR02168  552 VENLNAAKKAIAFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVddl 631

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   477 ---------------------------------AEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQ 523
Cdd:TIGR02168  632 dnalelakklrpgyrivtldgdlvrpggvitggSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELE 711

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   524 TSVTQVQQEKAELSQKIEELHACIEAAHQEQRQA-------QAHVTELEAQLKAEQQKV-----------AEREKVMQEK 585
Cdd:TIGR02168  712 EELEQLRKELEELSRQISALRKDLARLEAEVEQLeeriaqlSKELTELEAEIEELEERLeeaeeelaeaeAEIEELEAQI 791

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   586 AQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLM----------EQREQEQKALEQEKAGRKGL 655
Cdd:TIGR02168  792 EQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEdleeqieelsEDIESLAAEIEELEELIEEL 871

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   656 EARLQQLEEARQAETEAL---RRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEK 732
Cdd:TIGR02168  872 ESELEALLNERASLEEALallRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSL 951

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   733 AGQEAQEEAVEVhgEGQIGEQQSPLAQLHTTLAR----------ALQQVKE--KEVRAQK--LADDLTTLQEKMASTSKV 798
Cdd:TIGR02168  952 TLEEAEALENKI--EDDEEEARRRLKRLENKIKElgpvnlaaieEYEELKEryDFLTAQKedLTEAKETLEEAIEEIDRE 1029


                   .
gi 344240178   799 A 799
Cdd:TIGR02168 1030 A 1030
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 169-966 2.40e-30

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 132.49  E-value: 2.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   169 LEELRGKNESLTvRLHETLKQCQNLKTEKNQMDRKISQLSeengdlsfkVREFASHLQQLQGAFNDLTEEHNKASQEWAE 248
Cdd:TIGR02168  195 LNELERQLKSLE-RQAEKAERYKELKAELRELELALLVLR---------LEELREELEELQEELKEAEEELEELTAELQE 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   249 KQTHLEkelstALQDKKY-LEEKNEILQGKLSQLEERASQqCESpaqekgevlgdalQLETLKQEAAKLAAHNTQLQARI 327
Cdd:TIGR02168  265 LEEKLE-----ELRLEVSeLEEEIEELQKELYALANEISR-LEQ-------------QKQILRERLANLERQLEELEAQL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   328 ETLdcERSQQEAQLLAERghFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQ 407
Cdd:TIGR02168  326 EEL--ESKLDELAEELAE--LEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNE 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   408 --ELASLKEQAKKEQAQMVQSLQEQEQAAQglRQQVEQLSSSLKLKEQQLEEAAKDQEAARQdhaqQLAIVAEAREASLR 485
Cdd:TIGR02168  402 ieRLEARLERLEDRRERLQQEIEELLKKLE--EAELKELQAELEELEEELEELQEELERLEE----ALEELREELEEAEQ 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   486 ERDAARQQLETLEKEKAAkLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKI---EELHACIEAAHQEQRQA----- 557
Cdd:TIGR02168  476 ALDAAERELAQLQARLDS-LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELIsvdEGYEAAIEAALGGRLQAvvven 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   558 -QAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEE----------------------EKHRTA 614
Cdd:TIGR02168  555 lNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDlvkfdpklrkalsyllggvlvvDDLDNA 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   615 DALAEQQR-----------------CVTKMEAESRSLMEQREQEQKALEQEKAGRKG----LEARLQQLEEARQA---ET 670
Cdd:TIGR02168  635 LELAKKLRpgyrivtldgdlvrpggVITGGSAKTNSSILERRREIEELEEKIEELEEkiaeLEKALAELRKELEEleeEL 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   671 EALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALkGDHEKAGQEAQEEAVEVhgEGQI 750
Cdd:TIGR02168  715 EQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL-EEAEEELAEAEAEIEEL--EAQI 791

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   751 GEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLEL--LKEPPGAG 828
Cdd:TIGR02168  792 EQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIeeLEELIEEL 871

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   829 NKESNWLEEQRggpfSSPQAALKAMEQEAEQMGSELERLRvalmksqgqqqeergqqeREVARLTRERSQAQADLAQEKA 908
Cdd:TIGR02168  872 ESELEALLNER----ASLEEALALLRSELEELSEELRELE------------------SKRSELRRELEELREKLAQLEL 929

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178   909 AKAELEVRLQNTLNEQRVEFaalQEALDHALTEKEGKDQELAKLRGQEAAQRTELKEL 966
Cdd:TIGR02168  930 RLEGLEVRIDNLQERLSEEY---SLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 371-966 3.16e-30

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 131.60  E-value: 3.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  371 QAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQ--ELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSL 448
Cdd:COG1196   211 KAERYRELKEELKELEAELLLLKLRELEAELEELEAEleELEAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  449 KLKEQQLEEAAKDQEAARQDHAQQlaivAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQ 528
Cdd:COG1196   291 YELLAELARLEQDIARLEERRREL----EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  529 VQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEE 608
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  609 EKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAE 688
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAV 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  689 SESEQLIREVESWQKRFEA--RQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLAR 766
Cdd:COG1196   527 AVLIGVEAAYEAALEAALAaaLQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS 606

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  767 ALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAAclKTLVLKAGEQQEMTSLELLKEPPGAGNKESNWLEEQRggpfssp 846
Cdd:COG1196   607 DLREADARYYVLGDTLLGRTLVAARLEAALRRAV--TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEA------- 677

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  847 QAALKAMEQEAEQMGSELERLRVALmksqgqqqeergqqerevARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRV 926
Cdd:COG1196   678 EAELEELAERLAEEELELEEALLAE------------------EEEERELAEAEEERLEEELEEEALEEQLEAEREELLE 739

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 344240178  927 EFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKEL 966
Cdd:COG1196   740 ELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 137-707 3.46e-29

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 128.13  E-value: 3.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  137 EKDAQIAMMQQRIDHLAL-LNEKQAASSQESRELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEEngdls 215
Cdd:COG1196   236 ELEAELEELEAELEELEAeLEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER----- 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  216 fkvrefashLQQLQGAFNDLTEEHnkasQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQE 295
Cdd:COG1196   311 ---------RRELEERLEELEEEL----AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  296 KGEVLGDALQLETLKQEAAKLAAHNTQLQARIETL---DCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQA 372
Cdd:COG1196   378 EEELEELAEELLEALRAAAELAAQLEELEEAEEALlerLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE 457

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  373 KEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKE 452
Cdd:COG1196   458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE 537

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  453 QQLEEAAkdqEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQE 532
Cdd:COG1196   538 AALEAAL---AAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADAR 614

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  533 KAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQItkgsLEEEKHR 612
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE----LAERLAE 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  613 TADALAEQQrcvtkmEAESRSLMEQREQEQKALEQEKAGRKgLEARLQQLEEARQAETEALRRELAEATASQHRAESESE 692
Cdd:COG1196   691 EELELEEAL------LAEEEEERELAEAEEERLEEELEEEA-LEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763

                         570
                  ....*....|....*
gi 344240178  693 QLIREVESWQKRFEA 707
Cdd:COG1196   764 ELERELERLEREIEA 778
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 448-1443 2.92e-28

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 125.55  E-value: 2.92e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   448 LKLKEQQlEEAAKDQEAARQDHAQQLAIVAEAREA--SL-RERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQT 524
Cdd:TIGR02168  168 SKYKERR-KETERKLERTRENLDRLEDILNELERQlkSLeRQAEKAERYKELKAELRELELALLVLRLEELREELEELQE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   525 SVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLALEETLQITKG 604
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLE---QQKQILRERLANLERQLEELEA 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   605 SLEEEKHRtadaLAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARqaetEALRRELAEATASQ 684
Cdd:TIGR02168  324 QLEELESK----LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQL----ETLRSKVAQLELQI 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   685 HRAESESEQLIREVESWQKRFEARQQEearysamiqeQLAALKGDHEKAGQEAQEEAVEVhgEGQIGEQQSPLAQLHTTL 764
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRRERLQQE----------IEELLKKLEEAELKELQAELEEL--EEELEELQEELERLEEAL 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   765 ARALQQVKEKEVRAQKLADDLTTLQEKMAStskvaaclktlvLKAGEQQEMTSLELLKEppgagnkesNWLEEQRGGPFS 844
Cdd:TIGR02168  464 EELREELEEAEQALDAAERELAQLQARLDS------------LERLQENLEGFSEGVKA---------LLKNQSGLSGIL 522

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   845 SPQAALKAMEQEAEQMGSEL--ERLRVALMKSQGQQQeergqqerevarltrersQAQADLAQEKAAKA---ELEVRLQN 919
Cdd:TIGR02168  523 GVLSELISVDEGYEAAIEAAlgGRLQAVVVENLNAAK------------------KAIAFLKQNELGRVtflPLDSIKGT 584

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   920 TLNEQRVEFAALQEALDHALTEKEGKDQELAKL------------RGQEAAQRTELKELQQTLEHLKTQLVkkekeqHPA 987
Cdd:TIGR02168  585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAlsyllggvlvvdDLDNALELAKKLRPGYRIVTLDGDLV------RPG 658

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   988 GSTGGEEASAPEAQLETvrkteapdpevealRAEVSKLEQQCQQQKQQVeglthsleserasrAEQDKALETLQGQLEEK 1067
Cdd:TIGR02168  659 GVITGGSAKTNSSILER--------------RREIEELEEKIEELEEKI--------------AELEKALAELRKELEEL 710

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1068 TQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRL 1147
Cdd:TIGR02168  711 EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ 790

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1148 VVAESEKSQKLEERLrllqvetasssaraaersSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKawqe 1227
Cdd:TIGR02168  791 IEQLKEELKALREAL------------------DELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIE---- 848

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1228 kffQKEQALSALQLEHTSTQALVSELlpakhlcqqlqaeqAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGElgpLRQ 1307
Cdd:TIGR02168  849 ---ELSEDIESLAAEIEELEELIEEL--------------ESELEALLNERASLEEALALLRSELEELSEELRE---LES 908

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1308 KVAEQERAAQQLRAEKASYAEQLSMLKkahgllaeenrglGERANLgrqfleveLDQAREKYV---QELAAVRTDAETHL 1384
Cdd:TIGR02168  909 KRSELRRELEELREKLAQLELRLEGLE-------------VRIDNL--------QERLSEEYSltlEEAEALENKIEDDE 967

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  1385 AEMRQEAQSTTRELEVMTAKYEGAkvkvLEERQRFQEERQKLTAQVEELSKKLTEYDQA 1443
Cdd:TIGR02168  968 EEARRRLKRLENKIKELGPVNLAA----IEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
PTZ00121 PTZ00121
MAEBL; Provisional
 452-1244 1.26e-27

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 124.10  E-value: 1.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  452 EQQLEEAAKDQEAARQDhaqqlaIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEaanearDSVQTSVTQVQQ 531
Cdd:PTZ00121 1030 EELTEYGNNDDVLKEKD------IIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKE------DNRADEATEEAF 1097

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  532 EKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAErEKVMQEKAQLQEQLLALEETLQITKGSLEEEKH 611
Cdd:PTZ00121 1098 GKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAE-EARKAEDAKRVEIARKAEDARKAEEARKAEDAK 1176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  612 RTADAL-AEQQRCVTKMEA--ESRSLMEQR--EQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHR 686
Cdd:PTZ00121 1177 KAEAARkAEEVRKAEELRKaeDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRK 1256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  687 AESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEvhgegqigeqqsplaqlhttlAR 766
Cdd:PTZ00121 1257 FEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEE---------------------AK 1315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  767 ALQQVKEKEVRAQKLADDLttlqEKMASTSKVAACLKtlvlKAGEQQEMTSLELLKEPPGAGNKESNwlEEQRGGPFSSP 846
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAA----KKKAEEAKKAAEAA----KAEAEAAADEAEAAEEKAEAAEKKKE--EAKKKADAAKK 1385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  847 QAA-------LKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQaQADLAQEKAAKAELEVRLQN 919
Cdd:PTZ00121 1386 KAEekkkadeAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAK-KADEAKKKAEEAKKAEEAKK 1464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  920 TLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELK----ELQQTLEHLKTQLVKKEKEQHPAGSTGGEEA 995
Cdd:PTZ00121 1465 KAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKkkadEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  996 SAPEAQL---ETVRKTEAPDPEVEALRAE------VSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEE 1066
Cdd:PTZ00121 1545 KKKADELkkaEELKKAEEKKKAEEAKKAEedknmaLRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE 1624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1067 KTQELGHSQAASASAQRELTALHaKAQDHSKAEEEWK---AQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKE 1143
Cdd:PTZ00121 1625 LKKAEEEKKKVEQLKKKEAEEKK-KAEELKKAEEENKikaAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKK 1703

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1144 LKRLVVAESEKSQKLE-----ERLRLLQVETASssaRAAERSSALREEVQslREEVEKQRVisenlRQELTSQAERAEEL 1218
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEelkkaEEENKIKAEEAK---KEAEEDKKKAEEAK--KDEEEKKKI-----AHLKKEEEKKAEEI 1773

                         810       820
                  ....*....|....*....|....*.
gi 344240178 1219 GQELKAWQEKFFQKEQALSALQLEHT 1244
Cdd:PTZ00121 1774 RKEKEAVIEEELDEEDEKRRMEVDKK 1799
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 611-1536 2.40e-27

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 122.47  E-value: 2.40e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   611 HRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKG----LEARLQQLEEAR---QAETEALRRELAEATAS 683
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSLERQAEKAERYKELKAELRELelalLVLRLEELREELeelQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   684 QHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQlaalkgdhekagqeaqeeavevhgEGQIGEQQSPLAQLHTT 763
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL------------------------EQQKQILRERLANLERQ 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   764 LARALQQVKEKEVRAQKLADDLTTLQEKMASTskvaaclktlvlkageQQEMTSLEllkeppgagnkesnwleeqrggpf 843
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEELAELEEKLEEL----------------KEELESLE------------------------ 357

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   844 sspqAALKAMEQEAEQMGSELERLRVALmksqgqqqeerGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNE 923
Cdd:TIGR02168  358 ----AELEELEAELEELESRLEELEEQL-----------ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQE 422

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   924 QRVEFAALQEALDHAL-TEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGStggeEASAPEAQL 1002
Cdd:TIGR02168  423 IEELLKKLEEAELKELqAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA----RLDSLERLQ 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1003 ETVRKteaPDPEVEALRAEVSKLEQQCQQQKQQV---EGLTHSLESERASRAE------QDKALETLQGQ---------- 1063
Cdd:TIGR02168  499 ENLEG---FSEGVKALLKNQSGLSGILGVLSELIsvdEGYEAAIEAALGGRLQavvvenLNAAKKAIAFLkqnelgrvtf 575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1064 LEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKA---------------QVARGQQEAERKSSLISSLEEEVs 1128
Cdd:TIGR02168  576 LPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvddlDNALELAKKLRPGYRIVTLDGDL- 654

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1129 ILNRQVLEKEGESKELKRLvvAESEKSQKLEERLRLLQVETASSSARAAErssaLREEVQSLREEVEKQRVISENLRQEL 1208
Cdd:TIGR02168  655 VRPGGVITGGSAKTNSSIL--ERRREIEELEEKIEELEEKIAELEKALAE----LRKELEELEEELEQLRKELEELSRQI 728

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1209 TSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGL 1288
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1289 RAELMRaqrelgelgpLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEEnrglgeranlgrqfleveldqarek 1368
Cdd:TIGR02168  809 RAELTL----------LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSED------------------------- 853

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1369 yVQELAAVRTDAETHLAEMRQEAQSttrelevmtakyegakvkVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQ 1448
Cdd:TIGR02168  854 -IESLAAEIEELEELIEELESELEA------------------LLNERASLEEALALLRSELEELSEELRELESKRSELR 914

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1449 QKLKAFQAQGGESQQEVQRLQAQLNELQtqlsqkEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLrdleqlqkenKELR 1528
Cdd:TIGR02168  915 RELEELREKLAQLELRLEGLEVRIDNLQ------ERLSEEYSLTLEEAEALENKIEDDEEEARRRL----------KRLE 978


                   ....*...
gi 344240178  1529 AEAERLGR 1536
Cdd:TIGR02168  979 NKIKELGP 986
NuMA_LGNBD cd22298
LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins; ...
 1686-1744 3.92e-27

LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also called nuclear matrix protein-22 (NMP-22), nuclear mitotic apparatus protein 1 (NUMA1), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of spindle poles and the alignment and segregation of chromosomes during mitotic cell division. It is involved in the establishment of mitotic spindle orientation during metaphase, and elongation during anaphase in a dynein-dynactin-dependent manner. NuMA, in complex with LGN, forms NuMA:LGN hetero-hexamers that promote spindle orientation. The model corresponds to the LGN binding domain (LGNBD) of NuMA. LGN (named for leu-gly-asn repeats) is also known as G protein signaling modulator 2.


Pssm-ID: 412093  Cd Length: 56  Bit Score: 106.14  E-value: 3.92e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178 1686 LLSLPGYRPTTRSSARRSQarmSSGAPQGRNSFYMGTCQDEPEQLDDWNRIAELQQRNR 1744
Cdd:cd22298     1 LLSLPGYRPSTRSSTRRSQ---SSSATGGRSTFYMGTCQDEPEHLDDWNRIAELQQRNR 56
PTZ00121 PTZ00121
MAEBL; Provisional
 158-838 8.97e-27

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 121.02  E-value: 8.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  158 KQAASSQESRELEELRGKNESLTV----RLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAfn 233
Cdd:PTZ00121 1203 EAARKAEEERKAEEARKAEDAKKAeavkKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKA-- 1280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  234 dltEEHNKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKlsQLEERASQQCESpAQEKGEVLGDALQLETLKQEA 313
Cdd:PTZ00121 1281 ---DELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAK--KKAEEAKKKADA-AKKKAEEAKKAAEAAKAEAEA 1354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  314 AKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVAS 393
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD 1434

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  394 lTALNTTLQQQQDQELASLKEQAKKeqAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQL 473
Cdd:PTZ00121 1435 -EAKKKAEEAKKADEAKKKAEEAKK--AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKK 1511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  474 AivAEAREAS-LRERDAARQQLETLEKEKAAKLESLQQ--QLEAANEARDSVQtsVTQVQQEKAELSQKIEELHACIEAA 550
Cdd:PTZ00121 1512 A--DEAKKAEeAKKADEAKKAEEAKKADEAKKAEEKKKadELKKAEELKKAEE--KKKAEEAKKAEEDKNMALRKAEEAK 1587

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  551 HQEQRQAQA--HVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLqitKGSLEEEKHRTADALAEQQRCVTKME 628
Cdd:PTZ00121 1588 KAEEARIEEvmKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQL---KKKEAEEKKKAEELKKAEEENKIKAA 1664

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  629 AESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETeaLRRELAEATASQHRAESESEQLIREVESWQKRFE-- 706
Cdd:PTZ00121 1665 EEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE--LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEed 1742

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  707 ARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLT 786
Cdd:PTZ00121 1743 KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVIN 1822

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|..
gi 344240178  787 TLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESNWLEEQ 838
Cdd:PTZ00121 1823 DSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEK 1874
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 480-1115 1.38e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 119.66  E-value: 1.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  480 REASLRERDAARQQLETLE---KEKAAKLESLQQQLEAANEARdsvqtsvtQVQQEKAELsqKIEELHACIEAAHQEQRQ 556
Cdd:COG1196   174 KEEAERKLEATEENLERLEdilGELERQLEPLERQAEKAERYR--------ELKEELKEL--EAELLLLKLRELEAELEE 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  557 AQAHVTELEAQLKAEQQKVAEREKvmqEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLmE 636
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEA---ELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERL-E 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  637 QREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYS 716
Cdd:COG1196   320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  717 AMIQEQLAALKGDHEKAGQEAQEEAvevhgegqigEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTS 796
Cdd:COG1196   400 AQLEELEEAEEALLERLERLEEELE----------ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  797 KVAACLKTLVLKA-GEQQEMTSLELLKEppgagnkesNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALmkSQ 875
Cdd:COG1196   470 EEAALLEAALAELlEELAEAAARLLLLL---------EAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAY--EA 538

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  876 GQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQntlnEQRVEFAALQEALDHALTEKEGKDQELAKLRGQ 955
Cdd:COG1196   539 ALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDK----IRARAALAAALARGAIGAAVDLVASDLREADAR 614

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  956 EAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQ 1035
Cdd:COG1196   615 YYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE 694

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1036 VEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAE----EEWKAQVARGQQ 1111
Cdd:COG1196   695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEppdlEELERELERLER 774


                  ....
gi 344240178 1112 EAER 1115
Cdd:COG1196   775 EIEA 778
TRP_2 pfam08344
Transient receptor ion channel II; This domain is found in the transient receptor ion channel ...
 2387-2446 2.31e-26

Transient receptor ion channel II; This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).


Pssm-ID: 462438  Cd Length: 60  Bit Score: 103.82  E-value: 2.31e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2387 CACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARKEP 2446
Cdd:pfam08344    1 CGCDECKAERERDSLRHSLSRLNAYRALASPAYISLTSEDPILTAFELSWELRRLAFVEP 60
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1036-1578 1.49e-25

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 116.57  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1036 VEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAER 1115
Cdd:COG1196   227 AELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIAR 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1116 KSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVE 1195
Cdd:COG1196   307 LEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1196 KQRviseNLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR 1275
Cdd:COG1196   387 ELL----EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1276 EEIEQSKQAAGGLRAELMRAQRELGELGPlRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRG-------LG 1348
Cdd:COG1196   463 ELLAELLEEAALLEAALAELLEELAEAAA-RLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVeaayeaaLE 541

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1349 ERANLGRQFLEVELDQAREKYVQELAAVRTDAETHL---AEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQ----- 1420
Cdd:COG1196   542 AALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYvlgdt 621

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1421 -EERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKT- 1498
Cdd:COG1196   622 lLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLa 701

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1499 HYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGK 1578
Cdd:COG1196   702 EEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGP 781
PTZ00121 PTZ00121
MAEBL; Provisional
 385-1221 1.93e-25

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 116.78  E-value: 1.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  385 AQLTAQVASLTALNTTLQQQQ-DQELASLKEQAKKEQAQMVqslqeqEQAAQGLRQQVEQLSSSLKLKEQQlEEAAKDQE 463
Cdd:PTZ00121 1060 AEAKAHVGQDEGLKPSYKDFDfDAKEDNRADEATEEAFGKA------EEAKKTETGKAEEARKAEEAKKKA-EDARKAEE 1132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  464 AARQDHAQQlaiVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEArdsvqtsvtqVQQEKAELSQKIEEL 543
Cdd:PTZ00121 1133 ARKAEDARK---AEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKA----------EEVRKAEELRKAEDA 1199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  544 HACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRc 623
Cdd:PTZ00121 1200 RKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEAR- 1278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  624 vtKMEaESRSLMEQREQEQKALEQEKagRKGLEARlQQLEEARQAEtealrrelaEATASQHRAESESEQLIREVESWQK 703
Cdd:PTZ00121 1279 --KAD-ELKKAEEKKKADEAKKAEEK--KKADEAK-KKAEEAKKAD---------EAKKKAEEAKKKADAAKKKAEEAKK 1343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  704 RFEARQQEEARYSAMIQEQLAALKGDhEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEvRAQKLAD 783
Cdd:PTZ00121 1344 AAEAAKAEAEAAADEAEAAEEKAEAA-EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAA-AAKKKAD 1421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  784 DLttlqEKMASTSKVAACLKTlvlKAGEQQEMTSLELLKEPPGAGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSE 863
Cdd:PTZ00121 1422 EA----KKKAEEKKKADEAKK---KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEE 1494

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  864 LERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKE 943
Cdd:PTZ00121 1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEE 1574

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  944 GKDQELAK---LRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQhpagstggeeasapEAQLETVRKTEAPDPEVEALRA 1020
Cdd:PTZ00121 1575 DKNMALRKaeeAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEA--------------KIKAEELKKAEEEKKKVEQLKK 1640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1021 ----EVSKLEQQCQQqkqqveglthslESERASRAEQDKALEtlqgqlEEKTQELGHSQAASASAQRELTALHAKAQDHS 1096
Cdd:PTZ00121 1641 keaeEKKKAEELKKA------------EEENKIKAAEEAKKA------EEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK 1702

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1097 KAEeewkaQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEErlrLLQVETASSSARA 1176
Cdd:PTZ00121 1703 KAE-----ELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAH---LKKEEEKKAEEIR 1774

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*
gi 344240178 1177 AERSSALREEVqslREEVEKQRVISENLRQELTSQAERAEELGQE 1221
Cdd:PTZ00121 1775 KEKEAVIEEEL---DEEDEKRRMEVDKKIKDIFDNFANIIEGGKE 1816
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 770-1534 2.95e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 115.54  E-value: 2.95e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   770 QVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLkeppgAGNKESNWLEEQrggpFSSPQAA 849
Cdd:TIGR02168  219 KAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLE-----ELRLEVSELEEE----IEELQKE 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   850 LKAMEQEAEQMGSELERLRvalmKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVR---LQNTLNEQRV 926
Cdd:TIGR02168  290 LYALANEISRLEQQKQILR----ERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEElesLEAELEELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   927 EFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQlVKKEKEQHPAGSTGGEEASAPEAQLETVR 1006
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDR-RERLQQEIEELLKKLEEAELKELQAELEE 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1007 KTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDkALETLQGQLEEKTQELghsqAASASAQRELT 1086
Cdd:TIGR02168  445 LEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD-SLERLQENLEGFSEGV----KALLKNQSGLS 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1087 ALHAKAQDHSKAEEEWKA------------------QVARGQQEAERKSSLI-SSLEEEVSILNRQVLEKEGESKELKRL 1147
Cdd:TIGR02168  520 GILGVLSELISVDEGYEAaieaalggrlqavvvenlNAAKKAIAFLKQNELGrVTFLPLDSIKGTEIQGNDREILKNIEG 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1148 VVAESEKSQKLEERLRLL------QVETASSSARAAERSSALREE---VQSLREEVEKQRVI---SENLRQELTSQAERA 1215
Cdd:TIGR02168  600 FLGVAKDLVKFDPKLRKAlsyllgGVLVVDDLDNALELAKKLRPGyriVTLDGDLVRPGGVItggSAKTNSSILERRREI 679

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1216 EELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRA 1295
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1296 QRE----LGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR--EKY 1369
Cdd:TIGR02168  760 EAEieelEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAatERR 839

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1370 VQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAkvkvLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQ 1449
Cdd:TIGR02168  840 LEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAL----LNERASLEEALALLRSELEELSEELRELESKRSELRR 915

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1450 KLKAFQAQGGESQQEVQRLQAQLNELQtqlsqkEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKE----N- 1524
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEVRIDNLQ------ERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvNl 989

                          810
                   ....*....|...
gi 344240178  1525 ---KELRAEAERL 1534
Cdd:TIGR02168  990 aaiEEYEELKERY 1002
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 905-1519 3.76e-25

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 115.03  E-value: 3.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  905 QEKAAKAELEVRLQNTLNEQRVEFAALQeaLDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEq 984
Cdd:COG1196   206 ERQAEKAERYRELKEELKELEAELLLLK--LRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELE- 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  985 hpagstgGEEASAPEAQLETvrkteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQL 1064
Cdd:COG1196   283 -------LEEAQAEEYELLA---------ELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1065 EEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSIL----NRQVLEKEGE 1140
Cdd:COG1196   347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALlerlERLEEELEEL 426

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1141 SKELKRLVVAESEKSQKLEERLRLLQvETASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQ 1220
Cdd:COG1196   427 EEALAELEEEEEEEEEALEEAAEEEA-ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEG 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1221 ELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGG----LRAELMRAQ 1296
Cdd:COG1196   506 FLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGratfLPLDKIRAR 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1297 RELGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD-QAREKYVQELAA 1375
Cdd:COG1196   586 AALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEgEGGSAGGSLTGG 665

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1376 VRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQ 1455
Cdd:COG1196   666 SRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEE 745

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178 1456 AQGGESQQEVQRLQAQLNELQTQLSQKEQAAEhyklQMEK----AKTHYDAKKQQNQELQDQLRDLEQ 1519
Cdd:COG1196   746 ELLEEEALEELPEPPDLEELERELERLEREIE----ALGPvnllAIEEYEELEERYDFLSEQREDLEE 809
PTZ00121 PTZ00121
MAEBL; Provisional
 547-1526 5.38e-25

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 115.24  E-value: 5.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  547 IEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEE-KHRTADALAEQQRcvt 625
Cdd:PTZ00121 1052 IDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEArKAEEAKKKAEDAR--- 1128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 KMEAESRSlmeqrEQEQKALEQEKAGRKGLEARLQQLEEARQAEtEALRRELAEATASQHRAESeseqlIREVESWQKRF 705
Cdd:PTZ00121 1129 KAEEARKA-----EDARKAEEARKAEDAKRVEIARKAEDARKAE-EARKAEDAKKAEAARKAEE-----VRKAEELRKAE 1197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  706 EARQQEEARysamiqeqlaalKGDHEKAGQEAQEEAVEVHGEGqigeqqsplaqlhttlARALQQVKEKEVRAQKLADDL 785
Cdd:PTZ00121 1198 DARKAEAAR------------KAEEERKAEEARKAEDAKKAEA----------------VKKAEEAKKDAEEAKKAEEER 1249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  786 TTLQEKMASTSKVAA-CLKTLVLKAGEQQEMTSLELLKEPPGAgnKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSEL 864
Cdd:PTZ00121 1250 NNEEIRKFEEARMAHfARRQAAIKAEEARKADELKKAEEKKKA--DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA 1327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  865 ERLRVALMKsqgqqqeergqqerevaRLTRERSQAQADLAQEKAAKAELEVrlqntlNEQRVEFAALQealdhalTEKEG 944
Cdd:PTZ00121 1328 KKKADAAKK-----------------KAEEAKKAAEAAKAEAEAAADEAEA------AEEKAEAAEKK-------KEEAK 1377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  945 KDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAgstggEEAsapEAQLETVRKT-EAPDPEVEALRAEVS 1023
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKA-----DEA---KKKAEEKKKAdEAKKKAEEAKKADEA 1449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1024 KleqQCQQQKQQVEGLTHSLESERAS-----RAEQDKALETLQGQLEE---KTQELGHSQAASASAQRELTALHA-KAQD 1094
Cdd:PTZ00121 1450 K---KKAEEAKKAEEAKKKAEEAKKAdeakkKAEEAKKADEAKKKAEEakkKADEAKKAAEAKKKADEAKKAEEAkKADE 1526

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1095 HSKAEEEWKAQVARGQQEAERKSSLISSLE----EEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETA 1170
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKAEElkkaEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1171 --SSSARAAERSSALREEVQslREEVEKQRVisENLRQELTSQAERAEELGqelKAWQEKFFQKEQalsalqlehtstqa 1248
Cdd:PTZ00121 1607 mkAEEAKKAEEAKIKAEELK--KAEEEKKKV--EQLKKKEAEEKKKAEELK---KAEEENKIKAAE-------------- 1665

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1249 lvsellpakhlcqqlQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRAE---KAS 1325
Cdd:PTZ00121 1666 ---------------EAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKI 1730

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1326 YAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKY 1405
Cdd:PTZ00121 1731 KAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANI 1810

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1406 -EGAKvkvlEERQRFQEERQKLTAQVEELS-KKLTEYDQASKVQQQKLKAfQAQGGESQQEVQRLQAQLNELQTQLSQKE 1483
Cdd:PTZ00121 1811 iEGGK----EGNLVINDSKEMEDSAIKEVAdSKNMQLEEADAFEKHKFNK-NNENGEDGNKEADFNKEKDLKEDDEEEIE 1885

                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*.
gi 344240178 1484 QAAEHYKLQ---MEKAKTHYDAKKQQNQELQDQLrDLEQLQKENKE 1526
Cdd:PTZ00121 1886 EADEIEKIDkddIEREIPNNNMAGKNNDIIDDKL-DKDEYIKRDAE 1930
PTZ00121 PTZ00121
MAEBL; Provisional
 891-1549 1.84e-24

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 113.31  E-value: 1.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  891 RLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAK----LRGQEAAQRTElkEL 966
Cdd:PTZ00121 1110 KAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARkaedAKKAEAARKAE--EV 1187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  967 QQTLEHLKTQLVKKEKEQHPAGST-GGEEASAPE--AQLETVRKTE-APDPEVEALRAEvsKLEQQCQQQKQQVEGLTHS 1042
Cdd:PTZ00121 1188 RKAEELRKAEDARKAEAARKAEEErKAEEARKAEdaKKAEAVKKAEeAKKDAEEAKKAE--EERNNEEIRKFEEARMAHF 1265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1043 LESERASRAEQDKALETLQGQLEEKTQElghsQAASASAQRELTALHAKAQDHSKAEE--------EWKAQVARGQQEAE 1114
Cdd:PTZ00121 1266 ARRQAAIKAEEARKADELKKAEEKKKAD----EAKKAEEKKKADEAKKKAEEAKKADEakkkaeeaKKKADAAKKKAEEA 1341

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1115 RKSSLISSLEEEVSILNRQVLEKEGESKELKRlvvaESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQslREEV 1194
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKK----EEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELK--KAAA 1415

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1195 EKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1274
Cdd:PTZ00121 1416 AKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEA 1495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1275 REEIEQSKQAA-GGLRAELMRAQRELGELGPLRQkvAEQERAAQQLR-AEKASYAEQLsmlKKAHGLL-------AEENR 1345
Cdd:PTZ00121 1496 KKKADEAKKAAeAKKKADEAKKAEEAKKADEAKK--AEEAKKADEAKkAEEKKKADEL---KKAEELKkaeekkkAEEAK 1570

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1346 GLGERANLGRQFLEvELDQAREKYVQELAAVRTDAETHLAEMRQEAQSttrelevmtAKYEGAKVKVLEERQRFQEERQK 1425
Cdd:PTZ00121 1571 KAEEDKNMALRKAE-EAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE---------AKIKAEELKKAEEEKKKVEQLKK 1640

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1426 LTAQVEELSKKLTEYDQASKVQQQKLKafqaqggeSQQEVQRLQAQlnELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1505
Cdd:PTZ00121 1641 KEAEEKKKAEELKKAEEENKIKAAEEA--------KKAEEDKKKAE--EAKKAEEDEKKAAEALKKEAEEAKKAEELKKK 1710

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 344240178 1506 QNQElqdqLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAE 1549
Cdd:PTZ00121 1711 EAEE----KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK 1750
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 254-1258 9.45e-24

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 110.93  E-value: 9.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   254 EKELSTALQDKKYLEEKNEILQGKLSQLeeraSQQCESPAQEKGEVLG-DALQLETLKQEAaklaahnTQLQARIETLDC 332
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEK----RQQLERLRREREKAERyQALLKEKREYEG-------YELLKEKEALER 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   333 ERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTAlnttlqqqqdqELASL 412
Cdd:TIGR02169  238 QKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEA-----------EIASL 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   413 KEQAKkeqaqmvQSLQEQEQAAQGLRQQVEQLSSslklKEQQLEEAAKDQEAARQDHAQQLAIVAEAREaslrERDAARQ 492
Cdd:TIGR02169  307 ERSIA-------EKERELEDAEERLAKLEAEIDK----LLAEIEELEREIEEERKRRDKLTEEYAELKE----ELEDLRA 371

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   493 QLETLEKEKAA---KLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLK 569
Cdd:TIGR02169  372 ELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIK 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   570 AEQQKvaeREKVMQEKAQLQEQLLALEETLQItkgsLEEEkhrtadaLAEQQRCVTKMEAESRSLmEQREQEQKALEQE- 648
Cdd:TIGR02169  452 KQEWK---LEQLAADLSKYEQELYDLKEEYDR----VEKE-------LSKLQRELAEAEAQARAS-EERVRGGRAVEEVl 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   649 KAGRKGLEARLQQLEEARQAETEALrrelaEATASqhraeseseqlireveswqkrfearqqeeARYSAMIQEqlaalkg 728
Cdd:TIGR02169  517 KASIQGVHGTVAQLGSVGERYATAI-----EVAAG-----------------------------NRLNNVVVE------- 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   729 DHEKAgqeaqEEAVEVHGEGQIGeqqsPLAQLHTTLARALQQVKEKEVRAQKL--ADDLTTLQEKMASTSKVAAClKTLV 806
Cdd:TIGR02169  556 DDAVA-----KEAIELLKRRKAG----RATFLPLNKMRDERRDLSILSEDGVIgfAVDLVEFDPKYEPAFKYVFG-DTLV 625

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   807 LKAGE-------QQEMTSLE-LLKEPPGAgnkesnwleeQRGGPFSSPQAALKAMEQEAeqmgsELERLRVALMKsqgqq 878
Cdd:TIGR02169  626 VEDIEaarrlmgKYRMVTLEgELFEKSGA----------MTGGSRAPRGGILFSRSEPA-----ELQRLRERLEG----- 685

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   879 qeergqqerevarLTRERSQAQADLAqekaakaelevRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAA 958
Cdd:TIGR02169  686 -------------LKRELSSLQSELR-----------RIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE 741

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   959 QRTELKELQQTLEHLKTQLVKKEKEQhpagstggeeasapeAQLETvrkteapdpEVEALRAEVSKLEqqCQQQKQQVEG 1038
Cdd:TIGR02169  742 LEEDLSSLEQEIENVKSELKELEARI---------------EELEE---------DLHKLEEALNDLE--ARLSHSRIPE 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1039 LTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSS 1118
Cdd:TIGR02169  796 IQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEA 875

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1119 LISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASssarAAERSSALREEVQSLREEVEKQR 1198
Cdd:TIGR02169  876 ALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEA----LEEELSEIEDPKGEDEEIPEEEL 951

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  1199 VIsENLRQELTSQAERAEELG-------QELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKH 1258
Cdd:TIGR02169  952 SL-EDVQAELQRVEEEIRALEpvnmlaiQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKR 1017
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 899-1609 4.19e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 4.19e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   899 AQADLAQEKAAKAELEVRLqNTLNEQR---VEFAALQEALDHA-----LTEKEGKDQELAKLRGQEAAQRTELKELQQTL 970
Cdd:TIGR02168  184 TRENLDRLEDILNELERQL-KSLERQAekaERYKELKAELRELelallVLRLEELREELEELQEELKEAEEELEELTAEL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   971 EHLKTQLVKKEKEQHPAgstggeeasapEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASR 1050
Cdd:TIGR02168  263 QELEEKLEELRLEVSEL-----------EEEIEELQK------ELYALANEISRLEQQKQILRERLANLERQLEELEAQL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1051 AEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWkaqvargQQEAERKSSLISSLEEEVSIL 1130
Cdd:TIGR02168  326 EELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL-------EEQLETLRSKVAQLELQIASL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1131 N--RQVLEKEGESKElKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVISENLRQEL 1208
Cdd:TIGR02168  399 NneIERLEARLERLE-DRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQAL 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1209 TSQAERAEELGQELKAWQ------EKFFQKEQALSALQLEHTSTQALVSELL--PAKH-------LCQQLQAEQAAAEKR 1273
Cdd:TIGR02168  478 DAAERELAQLQARLDSLErlqenlEGFSEGVKALLKNQSGLSGILGVLSELIsvDEGYeaaieaaLGGRLQAVVVENLNA 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1274 HREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRAEKASYAEQLSM--------------LKKAHGL 1339
Cdd:TIGR02168  558 AKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvddLDNALEL 637

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1340 LAEENRGL-------------------GERANLGRQFLEVELDQAREKY-------------VQELAAVRTDAETHLAEM 1387
Cdd:TIGR02168  638 AKKLRPGYrivtldgdlvrpggvitggSAKTNSSILERRREIEELEEKIeeleekiaelekaLAELRKELEELEEELEQL 717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1388 RQEAQSTTRELEVMTAKYEGAKVKV---LEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQE 1464
Cdd:TIGR02168  718 RKELEELSRQISALRKDLARLEAEVeqlEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE 797

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1465 VQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQaglK 1544
Cdd:TIGR02168  798 LKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELES---E 874

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  1545 TKEAEQACRHLSAQVRSLEAQVAHADQQLRDL-GKFQVATDALKSREPQKPQLDLSIDSLDLSLEE 1609
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELeSKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 890-1567 4.48e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.61  E-value: 4.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   890 ARLTRERSQAQADLAQEKAAKAELEVRLqntlNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQT 969
Cdd:TIGR02168  242 EELQEELKEAEEELEELTAELQELEEKL----EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQ 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   970 LEHLKTQLVKKEKEQHPAGstggEEASAPEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERAS 1049
Cdd:TIGR02168  318 LEELEAQLEELESKLDELA----EELAELEEKLEELKE------ELESLEAELEELEAELEELESRLEELEEQLETLRSK 387

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1050 RAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAE------------EEWKAQVARGQQEAERKS 1117
Cdd:TIGR02168  388 VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKElqaeleeleeelEELQEELERLEEALEELR 467

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1118 SLISSLEEE--------------VSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAerssAL 1183
Cdd:TIGR02168  468 EELEEAEQAldaaerelaqlqarLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEA----AL 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1184 REEVQSL-REEVEKQRVISENLRQ---------ELTSQAERA-EELGQELKAWQEKFFQkeqALSALQLEHTSTQALVSE 1252
Cdd:TIGR02168  544 GGRLQAVvVENLNAAKKAIAFLKQnelgrvtflPLDSIKGTEiQGNDREILKNIEGFLG---VAKDLVKFDPKLRKALSY 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1253 LLPAKHLCQQLQAEQAAAEKRHREEIEQSKQ----------AAGGLRAELMRAQRElGELGPLRQKVAEQERAAQQLRAE 1322
Cdd:TIGR02168  621 LLGGVLVVDDLDNALELAKKLRPGYRIVTLDgdlvrpggviTGGSAKTNSSILERR-REIEELEEKIEELEEKIAELEKA 699

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1323 KASYAEQLS----MLKKAHGLLAEENRGLGE-RANLGRQFLEVELDQAR----EKYVQELAAVRTDAETHLAEMRQEAQS 1393
Cdd:TIGR02168  700 LAELRKELEeleeELEQLRKELEELSRQISAlRKDLARLEAEVEQLEERiaqlSKELTELEAEIEELEERLEEAEEELAE 779

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1394 TTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASK---VQQQKLKAFQAQGGESQQEVQRLQA 1470
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERriaATERRLEDLEEQIEELSEDIESLAA 859

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1471 QLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEqlqKENKELRAEAERLGRELQQAGLKTKEAEQ 1550
Cdd:TIGR02168  860 EIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELE---SKRSELRRELEELREKLAQLELRLEGLEV 936

                          730       740
                   ....*....|....*....|
gi 344240178  1551 ACRHLSAQVR---SLEAQVA 1567
Cdd:TIGR02168  937 RIDNLQERLSeeySLTLEEA 956
PTZ00121 PTZ00121
MAEBL; Provisional
 333-1202 1.51e-22

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 107.15  E-value: 1.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  333 ERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKE--ELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELA 410
Cdd:PTZ00121 1085 EDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDarKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDAR 1164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  411 SLKEQAKKEQAQMVQSLQEQEQAAQGlrQQVEQLSSSLKLKE-QQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDA 489
Cdd:PTZ00121 1165 KAEEARKAEDAKKAEAARKAEEVRKA--EELRKAEDARKAEAaRKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEA 1242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  490 ARqqletleKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAH-QEQRQAQahvtelEAQL 568
Cdd:PTZ00121 1243 KK-------AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKaEEKKKAD------EAKK 1309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  569 KAEQQKVAEREKVMQEKAQLQEQllALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQE 648
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAEEAKKKAD--AAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKA 1387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  649 KAGRKGLEARLQQLEEARQAEtealrrELAEATASQHRAES---ESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAA 725
Cdd:PTZ00121 1388 EEKKKADEAKKKAEEDKKKAD------ELKKAAAAKKKADEakkKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEE 1461

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  726 L--KGDHEKAGQEAQEEAVEvhgegqigeqqsplaqlhttlARALQQVKEKEVRAQKLADDLttlqEKMASTSKVAACLK 803
Cdd:PTZ00121 1462 AkkKAEEAKKADEAKKKAEE---------------------AKKADEAKKKAEEAKKKADEA----KKAAEAKKKADEAK 1516

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  804 tlvlKAGEQQEMTSLELLKEPPGAgnKESNWLEEQRGGPFSSPQAALKAMEQ--EAEQMGSELERLRVALMKSQGQQQEE 881
Cdd:PTZ00121 1517 ----KAEEAKKADEAKKAEEAKKA--DEAKKAEEKKKADELKKAEELKKAEEkkKAEEAKKAEEDKNMALRKAEEAKKAE 1590

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  882 RGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRT 961
Cdd:PTZ00121 1591 EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA 1670

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  962 ElkELQQTLEHLKtqlvKKEKEQHPAGSTGGEEASAPEaQLETVRKTEApdpevealrAEVSKLEQQCQQqkqqveglth 1041
Cdd:PTZ00121 1671 E--EDKKKAEEAK----KAEEDEKKAAEALKKEAEEAK-KAEELKKKEA---------EEKKKAEELKKA---------- 1724

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1042 slESERASRAEQDK--ALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSL 1119
Cdd:PTZ00121 1725 --EEENKIKAEEAKkeAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1120 ISSLEEEVSILNRQ-----VLEKEGESKELKRLVVAES---EKSQKLEERLRLLQVETASSSARAAERSSAlREEVQSLR 1191
Cdd:PTZ00121 1803 IFDNFANIIEGGKEgnlviNDSKEMEDSAIKEVADSKNmqlEEADAFEKHKFNKNNENGEDGNKEADFNKE-KDLKEDDE 1881

                         890
                  ....*....|.
gi 344240178 1192 EEVEKQRVISE 1202
Cdd:PTZ00121 1882 EEIEEADEIEK 1892
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 305-1115 2.09e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 106.29  E-value: 2.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   305 QLETLKQEAAK------LAAHNTQLQARIETLDCERSQQE-AQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELE 377
Cdd:TIGR02168  201 QLKSLERQAEKaerykeLKAELRELELALLVLRLEELREElEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   378 QASQAQGAQLTAQVASLTALNTTLQQQQdQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSslklKEQQLEE 457
Cdd:TIGR02168  281 EEIEELQKELYALANEISRLEQQKQILR-ERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE----LKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   458 AAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEkAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAEls 537
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL-NNEIERLEARLERLEDRRERLQQEIEELLKKLEE-- 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   538 QKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADAL 617
Cdd:TIGR02168  433 AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALL 512

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   618 AEQQRCVTKMEAESrSLMEQREQEQKALEqekagrKGLEARLQQL-----EEARQA-----ETEALRRELAEATASQHRA 687
Cdd:TIGR02168  513 KNQSGLSGILGVLS-ELISVDEGYEAAIE------AALGGRLQAVvvenlNAAKKAiaflkQNELGRVTFLPLDSIKGTE 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   688 ----ESESEQLIREVESWQKRFEarqQEEARYSAMIQEQLA------ALKGDHEKAGQEAQEEAV--------------- 742
Cdd:TIGR02168  586 iqgnDREILKNIEGFLGVAKDLV---KFDPKLRKALSYLLGgvlvvdDLDNALELAKKLRPGYRIvtldgdlvrpggvit 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   743 --EVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMAStskvaaclktlvLKAGEQQEMTSLEL 820
Cdd:TIGR02168  663 ggSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ------------LRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   821 LKEPPGAGNKESNWLEEQRGgPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQ 900
Cdd:TIGR02168  731 LRKDLARLEAEVEQLEERIA-QLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   901 ADLAQEKAAKAELEVRLQNTLNEQrvefAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLktqlvKK 980
Cdd:TIGR02168  810 AELTLLNEEAANLRERLESLERRI----AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAL-----LN 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   981 EKEQHPagstggEEASAPEAQLETVRKteapdpEVEALRAEVSKLEqqcqqqkqqvegltHSLESERASRAEQDKALETL 1060
Cdd:TIGR02168  881 ERASLE------EALALLRSELEELSE------ELRELESKRSELR--------------RELEELREKLAQLELRLEGL 934

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  1061 QGQLEEKTQELghsqaaSASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAER 1115
Cdd:TIGR02168  935 EVRIDNLQERL------SEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 137-805 9.71e-22

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 103.99  E-value: 9.71e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   137 EKDAQIAMMQQRIDHLAL-LNEKQAASSQESRELEELrGKNESLTVR-----LHETLKQCQNLKTEKNQ----MDRKISQ 206
Cdd:TIGR02169  248 SLEEELEKLTEEISELEKrLEEIEQLLEELNKKIKDL-GEEEQLRVKekigeLEAEIASLERSIAEKEReledAEERLAK 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   207 LSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLE---KELSTALQDKKYLEEKNEILQGKLSQLEE 283
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEevdKEFAETRDELKDYREKLEKLKREINELKR 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   284 RASQQCESPAQEKGEvlgdalqLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQ 363
Cdd:TIGR02169  407 ELDRLQEELQRLSEE-------LADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYD 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   364 SSISNLSQAKEELEQASQAQGAQLTAQ---VASLTALNTTLQ--QQQDQELASLKEQAKKE---------QAQMVQSLQE 429
Cdd:TIGR02169  480 RVEKELSKLQRELAEAEAQARASEERVrggRAVEEVLKASIQgvHGTVAQLGSVGERYATAievaagnrlNNVVVEDDAV 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   430 QEQAAQGLR---------------QQVEQLSSSLKLK------------EQQLEEAAK----------DQEAARqDHAQQ 472
Cdd:TIGR02169  560 AKEAIELLKrrkagratflplnkmRDERRDLSILSEDgvigfavdlvefDPKYEPAFKyvfgdtlvveDIEAAR-RLMGK 638

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   473 LAIVAEARE----------ASLRERDAARQQLETLEK--EKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKI 540
Cdd:TIGR02169  639 YRMVTLEGElfeksgamtgGSRAPRGGILFSRSEPAElqRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKI 718

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   541 EELHACIEAAHQEQRQAQAHVTELEAQLKAEQQkvaEREKVMQEKAQLQEQLLALEETLqitkGSLEEEKHRTADALAEQ 620
Cdd:TIGR02169  719 GEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ---EIENVKSELKELEARIEELEEDL----HKLEEALNDLEARLSHS 791

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   621 QrcVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQaETEALRRELAEATASQHRAESESEQLIREVES 700
Cdd:TIGR02169  792 R--IPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQ-ELQEQRIDLKEQIKSIEKEIENLNGKKEELEE 868

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   701 WQKRFEARQQEearysamIQEQLAALKGDHEKAgqeaqeeavevhgEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQK 780
Cdd:TIGR02169  869 ELEELEAALRD-------LESRLGDLKKERDEL-------------EAQLRELERKIEELEAQIEKKRKRLSELKAKLEA 928

                          730       740
                   ....*....|....*....|....*
gi 344240178   781 LADDLTTLQEKMASTSKVAACLKTL 805
Cdd:TIGR02169  929 LEEELSEIEDPKGEDEEIPEEELSL 953
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 655-1336 1.62e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 103.09  E-value: 1.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  655 LEARLQQLE-EARQAET-EALRRELAEATASQHRAEseseqlIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEK 732
Cdd:COG1196   198 LERQLEPLErQAEKAERyRELKEELKELEAELLLLK------LRELEAELEELEAELEELEAELEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  733 AGQEAQEEAVEVHgegqigEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQ 812
Cdd:COG1196   272 LRLELEELELELE------EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  813 QEMTSLELlkeppgagnkesnwleeqrggpfsspqAALKAMEQEAEQMGSELERLRVALmksqgqqqeergqqEREVARL 892
Cdd:COG1196   346 LEEAEEEL---------------------------EEAEAELAEAEEALLEAEAELAEA--------------EEELEEL 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  893 TRERSQAQADLAQEKAAKAELEVRLQNTLNEQrvefAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEH 972
Cdd:COG1196   385 AEELLEALRAAAELAAQLEELEEAEEALLERL----ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA 460

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  973 LKTQLVKKEKEQhPAGSTGGEEASAPEAQLETVRKT-EAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRA 1051
Cdd:COG1196   461 LLELLAELLEEA-ALLEAALAELLEELAEAAARLLLlLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1052 EQDKALETLQGQLEEKTQELghSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERksSLISSLEEEVSILN 1131
Cdd:COG1196   540 LEAALAAALQNIVVEDDEVA--AAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAV--DLVASDLREADARY 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1132 RQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQ 1211
Cdd:COG1196   616 YVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELEL 695

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1212 AERAEELGQELKawqekffQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAE 1291
Cdd:COG1196   696 EEALLAEEEEER-------ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 344240178 1292 LMRAQRELGELGP--LRqkvAEQEraAQQLRAEKASYAEQLSMLKKA 1336
Cdd:COG1196   769 LERLEREIEALGPvnLL---AIEE--YEELEERYDFLSEQREDLEEA 810
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 145-1228 4.42e-21

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 101.79  E-value: 4.42e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   145 MQQRIDHLALLNEKQaasSQESRELEELRGKNESLT---VRLHETLKQCQNLKTEKNQMDRKIS----QLSEENGDLSFK 217
Cdd:pfam01576    7 MQAKEEELQKVKERQ---QKAESELKELEKKHQQLCeekNALQEQLQAETELCAEAEEMRARLAarkqELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   218 VREFASHLQQLQGAFNDLTE-----EHNKASQEWAEKQTHLEKeLSTALQDKKY------LEEKNEILQGKLSQLEERAS 286
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQhiqdlEEQLDEEEAARQKLQLEK-VTTEAKIKKLeedillLEDQNSKLSKERKLLEERIS 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   287 QQCESPAQEKGEVlgDALQLETLKQEAAKlaahnTQLQARIETldCERSQQEaqllaerghFEEEKQQLASLIADLQSSI 366
Cdd:pfam01576  163 EFTSNLAEEEEKA--KSLSKLKNKHEAMI-----SDLEERLKK--EEKGRQE---------LEKAKRKLEGESTDLQEQI 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   367 SNLSQAKEELEqasqaqgAQLTAQVASLTALNTTLQQQQDQELASLKeQAKKEQAQmVQSLQEQEQAAQGLRQQVEQ--- 443
Cdd:pfam01576  225 AELQAQIAELR-------AQLAKKEEELQAALARLEEETAQKNNALK-KIRELEAQ-ISELQEDLESERAARNKAEKqrr 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   444 -LSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSV 522
Cdd:pfam01576  296 dLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANL 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQL-KAEQQKVAEREKVMQEKAQLQEQLLALEET--- 598
Cdd:pfam01576  376 EKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLsESERQRAELAEKLSKLQSELESVSSLLNEAegk 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   599 ---LQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLeearQAETEALRR 675
Cdd:pfam01576  456 nikLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTL----QAQLSDMKK 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   676 ELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAM---IQEQLAALKGDHEKAGQEAQE-EAVEVHGEGQIG 751
Cdd:pfam01576  532 KLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTknrLQQELDDLLVDLDHQRQLVSNlEKKQKKFDQMLA 611

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   752 EQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTlvlkageqqEMTSLELLKEPPGagnKE 831
Cdd:pfam01576  612 EEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRA---------EMEDLVSSKDDVG---KN 679

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   832 SNWLEEQRggpfsspqaalKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERsQAQADLAQEKAAKA 911
Cdd:pfam01576  680 VHELERSK-----------RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDL-QARDEQGEEKRRQL 747

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   912 ELEVR-LQNTLNEQRVEFAA-----------LQEALDHALTEKEGKDQELAKLRGQEAaqrtELKELQQTLEHLKTQlvk 979
Cdd:pfam01576  748 VKQVReLEAELEDERKQRAQavaakkkleldLKELEAQIDAANKGREEAVKQLKKLQA----QMKDLQRELEEARAS--- 820

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   980 keKEQHPAGSTggeeasapeaqlETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLE---SERASRAEQDKA 1056
Cdd:pfam01576  821 --RDEILAQSK------------ESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIAsgaSGKSALQDEKRR 886

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1057 LETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKS------------------- 1117
Cdd:pfam01576  887 LEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNkelkaklqemegtvkskfk 966

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1118 SLISSLEEEVSILNRQvLEKEGESKELKRLVVAESEKsqKLEERLrlLQVETASSSA--------RAAERSSALREEVQS 1189
Cdd:pfam01576  967 SSIAALEAKIAQLEEQ-LEQESRERQAANKLVRRTEK--KLKEVL--LQVEDERRHAdqykdqaeKGNSRMKQLKRQLEE 1041

                         1130      1140      1150
                   ....*....|....*....|....*....|....*....
gi 344240178  1190 LREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEK 1228
Cdd:pfam01576 1042 AEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
453-1127 1.47e-20

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 100.37  E-value: 1.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  453 QQLEEAAKDQEAARQdhaqQLAIVAEAREASlRERDAARQQLETLEKEKAA-KLESLQQQLEAANEARDSVQTSVTQVQQ 531
Cdd:COG4913   235 DDLERAHEALEDARE----QIELLEPIRELA-ERYAAARERLAELEYLRAAlRLWFAQRRLELLEAELEELRAELARLEA 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  532 EKAELSQKIEELHACIEAAHQEQRQAQ-AHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLALEETLQITKGSLEEEK 610
Cdd:COG4913   310 ELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERE---RRRARLEALLAALGLPLPASAEEFAALR 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  611 HRTADALAEqqrcvtkMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLeEARQ----AETEALRRELAEATasqhr 686
Cdd:COG4913   387 AEAAALLEA-------LEEELEALEEALAEAEAALRDLRRELRELEAEIASL-ERRKsnipARLLALRDALAEAL----- 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  687 AESESE--------QLIREVESWQKRFEA--RQQ------EEARYSAMiqeqLAALkgDHEKAGQEAQEEAVEVHGEGQI 750
Cdd:COG4913   454 GLDEAElpfvgeliEVRPEEERWRGAIERvlGGFaltllvPPEHYAAA----LRWV--NRLHLRGRLVYERVRTGLPDPE 527

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  751 GEQQSPlaqlhTTLARALqQVKEKEVRAqkladdltTLQEKMASTSKVAACLKTLVLKaGEQQEMTSLELLKEPPGAGNK 830
Cdd:COG4913   528 RPRLDP-----DSLAGKL-DFKPHPFRA--------WLEAELGRRFDYVCVDSPEELR-RHPRAITRAGQVKGNGTRHEK 592

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  831 ESNWLEEQR---GgpfSSPQAALKAMEQEAEQMGSELERLRvALMKSQGQQQEERGQQEREVARLtRERSQAQADLAQEK 907
Cdd:COG4913   593 DDRRRIRSRyvlG---FDNRAKLAALEAELAELEEELAEAE-ERLEALEAELDALQERREALQRL-AEYSWDEIDVASAE 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  908 AAKAELEVRLQNtLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQhpa 987
Cdd:COG4913   668 REIAELEAELER-LDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLA--- 743

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  988 gstggeeASAPEAQLETVRKTEAPDPEVEALRAEvskleqqcqqqkqqvegLTHSLESERASRAEQDKALETLQGQLEEK 1067
Cdd:COG4913   744 -------RLELRALLEERFAAALGDAVERELREN-----------------LEERIDALRARLNRAEEELERAMRAFNRE 799

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1068 TQELGHSQAASASAQRELTALHAKAQDHS--KAEEEWKAQVARgqQEAERKSSLISSLEEEV 1127
Cdd:COG4913   800 WPAETADLDADLESLPEYLALLDRLEEDGlpEYEERFKELLNE--NSIEFVADLLSKLRRAI 859
PTZ00121 PTZ00121
MAEBL; Provisional
 909-1551 2.06e-20

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 100.22  E-value: 2.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  909 AKAELEVRLQNTLNEQRVEFAALQEAL-DHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHL-KTQLVKKEKEQHP 986
Cdd:PTZ00121 1062 AKAHVGQDEGLKPSYKDFDFDAKEDNRaDEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDArKAEEARKAEDARK 1141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  987 AgstggEEASAPE--AQLETVRKTEapdpevEALRAEVSKleqqcqqqkqqveglthslESERASRAEQ-DKALETLQGQ 1063
Cdd:PTZ00121 1142 A-----EEARKAEdaKRVEIARKAE------DARKAEEAR-------------------KAEDAKKAEAaRKAEEVRKAE 1191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1064 LEEKTQELGHSQAASASAQREltalhaKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKE 1143
Cdd:PTZ00121 1192 ELRKAEDARKAEAARKAEEER------KAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHF 1265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1144 LKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSAlrEEVQSLREEVEKQRVISENlRQELTSQAERAEELGQELK 1223
Cdd:PTZ00121 1266 ARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKA--DEAKKKAEEAKKADEAKKK-AEEAKKKADAAKKKAEEAK 1342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1224 AWQEKFFQKEQAlSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELG 1303
Cdd:PTZ00121 1343 KAAEAAKAEAEA-AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKAD 1421

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1304 PLRQKvAEQERAAQQLR--AEKASYAEQLSmlKKAHGLLAEENrgLGERANLGRQFLEVELDQAREKYVQELAAVRTDAE 1381
Cdd:PTZ00121 1422 EAKKK-AEEKKKADEAKkkAEEAKKADEAK--KKAEEAKKAEE--AKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAK 1496

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1382 THLAEMRQEAQSTTRELEVMTAKyegaKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQ--QQKLKAFQAQGG 1459
Cdd:PTZ00121 1497 KKADEAKKAAEAKKKADEAKKAE----EAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKkaEEKKKAEEAKKA 1572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1460 ESQ-------------------QEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQL 1520
Cdd:PTZ00121 1573 EEDknmalrkaeeakkaeeariEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEEL 1652

                         650       660       670
                  ....*....|....*....|....*....|.
gi 344240178 1521 QKENKELRAEAERLGRELQQAGLKTKEAEQA 1551
Cdd:PTZ00121 1653 KKAEEENKIKAAEEAKKAEEDKKKAEEAKKA 1683
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 453-1541 2.79e-20

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 99.48  E-value: 2.79e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   453 QQLEEAAKDQEAARQDHAQQLAivaearEASLRERDAARQQLEtleKEKAAKLESLQQQLEAANEA---RDSVQTSVTQV 529
Cdd:pfam01576    3 QEEEMQAKEEELQKVKERQQKA------ESELKELEKKHQQLC---EEKNALQEQLQAETELCAEAeemRARLAARKQEL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   530 QQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQqkvAEREKVMQEKAQLQEQLLALEE---TLQITKGSL 606
Cdd:pfam01576   74 EEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEE---AARQKLQLEKVTTEAKIKKLEEdilLLEDQNSKL 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   607 EEEKHRTADALAEQQRCVTKMEAESRSLmeqreqeQKALEQEKAGRKGLEARLQQLEEARQaETEALRRELAEATASQHR 686
Cdd:pfam01576  151 SKERKLLEERISEFTSNLAEEEEKAKSL-------SKLKNKHEAMISDLEERLKKEEKGRQ-ELEKAKRKLEGESTDLQE 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   687 AESESEQLIREVeswqkRFEARQQEEarysamiqEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLAR 766
Cdd:pfam01576  223 QIAELQAQIAEL-----RAQLAKKEE--------ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNK 289

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   767 ALQQVKEkevraqkLADDLTTLQEKMASTSKVAACLKTLvlKAGEQQEMTSLEllkeppGAGNKESNWLEEQRGGPFSSP 846
Cdd:pfam01576  290 AEKQRRD-------LGEELEALKTELEDTLDTTAAQQEL--RSKREQEVTELK------KALEEETRSHEAQLQEMRQKH 354

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   847 QAALKAMEQEAEQMG---SELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLaQEKAAKAELEVRLQNTLNE 923
Cdd:pfam01576  355 TQALEELTEQLEQAKrnkANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQL-QELQARLSESERQRAELAE 433

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   924 QRVEFAALQEALDHALTEKEGKDQELAK--------------LRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGS 989
Cdd:pfam01576  434 KLSKLQSELESVSSLLNEAEGKNIKLSKdvsslesqlqdtqeLLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKR 513

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   990 TGGEEASAPEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQ 1069
Cdd:pfam01576  514 NVERQLSTLQAQLSDMKK------KLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLV 587

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1070 ELGHsqaasasaQREL-TALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRlv 1148
Cdd:pfam01576  588 DLDH--------QRQLvSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELER-- 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1149 vaeSEKSQKLEERLRLLQVETASSSARAAERSS-ALREEVQSLR---EEVEKQRVISEN--LRQELTSQAERA------- 1215
Cdd:pfam01576  658 ---TNKQLRAEMEDLVSSKDDVGKNVHELERSKrALEQQVEEMKtqlEELEDELQATEDakLRLEVNMQALKAqferdlq 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1216 --EELGQELK------------AWQEKFFQKEQALSA---LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEI 1278
Cdd:pfam01576  735 arDEQGEEKRrqlvkqvreleaELEDERKQRAQAVAAkkkLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQREL 814

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1279 EQSKQA--------------AGGLRAELMRAQRELgelgplrqkvAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1344
Cdd:pfam01576  815 EEARASrdeilaqskesekkLKNLEAELLQLQEDL----------AASERARRQAQQERDELADEIASGASGKSALQDEK 884

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1345 RGLGERAnlgrQFLEVELDQarEKYVQELAAVRTDAETHLAEMRQEAQSTTRELevmTAKYEGAkvkvleerqrfqeeRQ 1424
Cdd:pfam01576  885 RRLEARI----AQLEEELEE--EQSNTELLNDRLRKSTLQVEQLTTELAAERST---SQKSESA--------------RQ 941

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1425 KLTAQVEELSKKLTEYDQASKVQQQ--------KLKAFQAQGGESQQE-------VQRLQAQLNELQTQLSQKEQAAEHY 1489
Cdd:pfam01576  942 QLERQNKELKAKLQEMEGTVKSKFKssiaaleaKIAQLEEQLEQESRErqaanklVRRTEKKLKEVLLQVEDERRHADQY 1021

                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|..
gi 344240178  1490 KLQMEKAkthydakkqqNQELQDQLRDLEQLQKENKELRAEAERLGRELQQA 1541
Cdd:pfam01576 1022 KDQAEKG----------NSRMKQLKRQLEEAEEEASRANAARRKLQRELDDA 1063
PTZ00121 PTZ00121
MAEBL; Provisional
 808-1533 8.47e-20

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 98.29  E-value: 8.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  808 KAGEQQEMTSLELLKepPGAGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQER 887
Cdd:PTZ00121 1059 KAEAKAHVGQDEGLK--PSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKA 1136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  888 EVARLTRERSQAQADLAQEKAAKAELEVRLQNTlneQRVEFAALQEALDHAltEKEGKDQELAK---LRGQEAAQRTE-- 962
Cdd:PTZ00121 1137 EDARKAEEARKAEDAKRVEIARKAEDARKAEEA---RKAEDAKKAEAARKA--EEVRKAEELRKaedARKAEAARKAEee 1211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  963 --LKELQQTLEHLKTQLVKKEKEqhpaGSTGGEEASAPEAQ--LETVRKTEAPDPEVEALRAEVSKLEQQCQQQKqqVEG 1038
Cdd:PTZ00121 1212 rkAEEARKAEDAKKAEAVKKAEE----AKKDAEEAKKAEEErnNEEIRKFEEARMAHFARRQAAIKAEEARKADE--LKK 1285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1039 LTHSLESERASRAEQDKALETLQGQLEEKtQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSS 1118
Cdd:PTZ00121 1286 AEEKKKADEAKKAEEKKKADEAKKKAEEA-KKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEE 1364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1119 LISSLEEEVSILNRQVLEKEGESKELKRlvvAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQ---SLREEVE 1195
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKKADAAKKKAEEKKK---ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKkadEAKKKAE 1441

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1196 KQRVISE-NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQAL--VSELLPAKHLCQQLQAEQAAAEK 1272
Cdd:PTZ00121 1442 EAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKkkADEAKKAAEAKKKADEAKKAEEA 1521

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1273 RHREEI---EQSKQAAGGLRAELMRAQRELGELGPLRQ----KVAEQERAAQQLRAEKASYAEQLSMLKKAH-----GLL 1340
Cdd:PTZ00121 1522 KKADEAkkaEEAKKADEAKKAEEKKKADELKKAEELKKaeekKKAEEAKKAEEDKNMALRKAEEAKKAEEARieevmKLY 1601

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1341 AEENRGLGERANLGRQFL----EVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEER 1416
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKikaeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAK 1681

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1417 QRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQtqlsQKEQAAEHYKLQMEKA 1496
Cdd:PTZ00121 1682 KAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEE----DKKKAEEAKKDEEEKK 1757

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|.
gi 344240178 1497 KTHYDAKKQQNQELQDQLRDL----EQLQKENKELRAEAER 1533
Cdd:PTZ00121 1758 KIAHLKKEEEKKAEEIRKEKEavieEELDEEDEKRRMEVDK 1798
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 946-1609 2.96e-19

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 95.91  E-value: 2.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   946 DQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPA--------------GSTGGEEASAPEAQLETVRKT-EA 1010
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAeryqallkekreyeGYELLKEKEALERQKEAIERQlAS 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1011 PDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKA--------LETLQGQLEEKTQELGHSQAASASAQ 1082
Cdd:TIGR02169  249 LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEkigeleaeIASLERSIAEKERELEDAEERLAKLE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1083 RELTALHAKAQDHSKAEEEWKAQVARGQQEaerksslISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERL 1162
Cdd:TIGR02169  329 AEIDKLLAEIEELEREIEEERKRRDKLTEE-------YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1163 RLLQVETASSSARAAERSSA---LREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSAL 1239
Cdd:TIGR02169  402 NELKRELDRLQEELQRLSEEladLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRV 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1240 QLEHTSTQALVSELLPAKhlcqQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQR------ELGELGPLRQKVAEQE 1313
Cdd:TIGR02169  482 EKELSKLQRELAEAEAQA----RASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGEryataiEVAAGNRLNNVVVEDD 557

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1314 ----RAAQQLRAEKASYAEQLSMLK-KAHGLLAE---ENRGLGERANLgrqfleVELDQARE---KYVQELAAVRTDAET 1382
Cdd:TIGR02169  558 avakEAIELLKRRKAGRATFLPLNKmRDERRDLSilsEDGVIGFAVDL------VEFDPKYEpafKYVFGDTLVVEDIEA 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1383 HLAEMRQeAQSTTRELEV------MTAKY------EGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQK 1450
Cdd:TIGR02169  632 ARRLMGK-YRMVTLEGELfeksgaMTGGSraprggILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQE 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1451 LKAFQAQGGESQQEVQRLQAQLN-------ELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQ--LQ 1521
Cdd:TIGR02169  711 LSDASRKIGEIEKEIEQLEQEEEklkerleELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEArlSH 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1522 KENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLgkfqvaTDALKSREPQKPQLDLSID 1601
Cdd:TIGR02169  791 SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL------KEQIKSIEKEIENLNGKKE 864


                   ....*...
gi 344240178  1602 SLDLSLEE 1609
Cdd:TIGR02169  865 ELEEELEE 872
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 534-1442 4.19e-19

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 95.52  E-value: 4.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   534 AELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLK--AEQQKVAEREKVMQEKAQLQEQLLALEEtlqitKGSLEEEKH 611
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLErlRREREKAERYQALLKEKREYEGYELLKE-----KEALERQKE 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   612 RTADALAEQQRCVTKMEAEsrslMEQREQEQKALEQEkagRKGLEARLQQLEEARQAeteALRRELAEATASQHRAESEs 691
Cdd:TIGR02169  241 AIERQLASLEEELEKLTEE----ISELEKRLEEIEQL---LEELNKKIKDLGEEEQL---RVKEKIGELEAEIASLERS- 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   692 eqlIREVESWQKRFEARQQEearysamIQEQLAALKGDHEKAGQEAQEEAVEVHgegQIGEQqspLAQLHTTLARALQQV 771
Cdd:TIGR02169  310 ---IAEKERELEDAEERLAK-------LEAEIDKLLAEIEELEREIEEERKRRD---KLTEE---YAELKEELEDLRAEL 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   772 KEKEVRAQKLADDLTTLQEKmastskvaaclktlvlkageqqemtsLELLKEPPGAGNKESNWLEEQrggpfsspqaaLK 851
Cdd:TIGR02169  374 EEVDKEFAETRDELKDYREK--------------------------LEKLKREINELKRELDRLQEE-----------LQ 416

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   852 AMEQEAEQMGSELERLRVALMKSQGQQQEERGQqereVARLTRERSQAQADLaqeKAAKAELEvRLQNTLNEQRVEFAAL 931
Cdd:TIGR02169  417 RLSEELADLNAAIAGIEAKINELEEEKEDKALE----IKKQEWKLEQLAADL---SKYEQELY-DLKEEYDRVEKELSKL 488

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   932 QEALDHALTEKEGKDQElaklRGQEAAQRTELKELQQTLEHLKTQLVK-KEKEQHPAGSTGG---------EEASAPEA- 1000
Cdd:TIGR02169  489 QRELAEAEAQARASEER----VRGGRAVEEVLKASIQGVHGTVAQLGSvGERYATAIEVAAGnrlnnvvveDDAVAKEAi 564

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1001 ----QLETVRKTEAPDPEVEALRAEVSKL---------------EQQCQQQKQQVEGLTHSLESERASRAEQDKA-LETL 1060
Cdd:TIGR02169  565 ellkRRKAGRATFLPLNKMRDERRDLSILsedgvigfavdlvefDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYrMVTL 644

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1061 QGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGE 1140
Cdd:TIGR02169  645 EGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKE 724

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1141 SKELKRLVVAESEKSQKLEERLRLLQVETA---SSSARAAERSSALREEVQSLREEVEK-QRVISENLRQELTSQAERAE 1216
Cdd:TIGR02169  725 IEQLEQEEEKLKERLEELEEDLSSLEQEIEnvkSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQAELSKLE 804

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1217 ElgqELKAWQEKFFQKEQALSALQLEHTSTQALVSELLpakhlcqQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQ 1296
Cdd:TIGR02169  805 E---EVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQ-------EQRIDLKEQIKSIEKEIENLNGKKEELEEELEELE 874

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1297 RELGELGP-----------LRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDqa 1365
Cdd:TIGR02169  875 AALRDLESrlgdlkkerdeLEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELS-- 952

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  1366 rekyvqelaavrtdaETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQ 1442
Cdd:TIGR02169  953 ---------------LEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEK 1014
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 305-1367 5.35e-19

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 95.24  E-value: 5.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   305 QLETLKQEAAKL-AAHNTQLQARIETLDCERSQQeaQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQ 383
Cdd:pfam01576    3 QEEEMQAKEEELqKVKERQQKAESELKELEKKHQ--QLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   384 GAQLtaqvasltalnttlqqQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQ--QVEQLSSSLKLKE--------- 452
Cdd:pfam01576   81 ESRL----------------EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQklQLEKVTTEAKIKKleedillle 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   453 ----------QQLEEAAKD---QEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEkaakLESLQQQLEA-ANEA 518
Cdd:pfam01576  145 dqnsklskerKLLEERISEftsNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQE----LEKAKRKLEGeSTDL 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   519 RDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQ---AQAHVTELEAQLkAEQQKVAEREKVMQEKAQLQEQllAL 595
Cdd:pfam01576  221 QEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQknnALKKIRELEAQI-SELQEDLESERAARNKAEKQRR--DL 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   596 EETLQITKGSLEEekhrTADALAEQQRCVTKMEAESRSLmeqreqeQKALEQEKagrKGLEARLQQLEEARQAETEALRR 675
Cdd:pfam01576  298 GEELEALKTELED----TLDTTAAQQELRSKREQEVTEL-------KKALEEET---RSHEAQLQEMRQKHTQALEELTE 363

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   676 ELAEAT-------ASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEqLAALKGDHEKAGQEAQEEAVEVHGE- 747
Cdd:pfam01576  364 QLEQAKrnkanleKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQE-LQARLSESERQRAELAEKLSKLQSEl 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   748 ----GQIGEQQSPLAQLHTTLARA---LQQVKE--KEVRAQKLA---------DDLTTLQEKM----ASTSKVAACLKTL 805
Cdd:pfam01576  443 esvsSLLNEAEGKNIKLSKDVSSLesqLQDTQEllQEETRQKLNlstrlrqleDERNSLQEQLeeeeEAKRNVERQLSTL 522

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   806 V-----LKAGEQQEMTSLELLKEPPGAGNKESNWLEEQrggpFSSPQAALKAMEQEAEQMGSELERLRV----------A 870
Cdd:pfam01576  523 QaqlsdMKKKLEEDAGTLEALEEGKKRLQRELEALTQQ----LEEKAAAYDKLEKTKNRLQQELDDLLVdldhqrqlvsN 598

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   871 LMKSQGQQQEERGQQEREVARLTRERSQAQADlAQEKAAKAELEVRLQNTLNEQRVEF----AALQEALDHALTEKEGKD 946
Cdd:pfam01576  599 LEKKQKKFDQMLAEEKAISARYAEERDRAEAE-AREKETRALSLARALEEALEAKEELertnKQLRAEMEDLVSSKDDVG 677

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   947 QELAKLrgqEAAQRTelkeLQQTLEHLKTQLVKKEKEQHPAgstggEEA--------SAPEAQLEtvRKTEAPDPEVEAL 1018
Cdd:pfam01576  678 KNVHEL---ERSKRA----LEQQVEEMKTQLEELEDELQAT-----EDAklrlevnmQALKAQFE--RDLQARDEQGEEK 743

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1019 RAEVSKleqqcqqqkqQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKA 1098
Cdd:pfam01576  744 RRQLVK----------QVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRE 813

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1099 EEEWKAQvargqqeaeRKSSLISSLEEEvsilnRQVLEKEGESKELKR-LVVAESEKSQKLEERLRLLQVETASSSARAA 1177
Cdd:pfam01576  814 LEEARAS---------RDEILAQSKESE-----KKLKNLEAELLQLQEdLAASERARRQAQQERDELADEIASGASGKSA 879

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1178 --ERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSEL-- 1253
Cdd:pfam01576  880 lqDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMeg 959

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1254 -LPAKHLCQQLQAEQAAAEKRHREEIE-QSKQAAGGLraeLMRAQRELGElgpLRQKVAEQERAAQQLRAEKASYAEQLS 1331
Cdd:pfam01576  960 tVKSKFKSSIAALEAKIAQLEEQLEQEsRERQAANKL---VRRTEKKLKE---VLLQVEDERRHADQYKDQAEKGNSRMK 1033

                         1130      1140      1150
                   ....*....|....*....|....*....|....*.
gi 344240178  1332 MLKKAHGLLAEENrglgERANLGRQFLEVELDQARE 1367
Cdd:pfam01576 1034 QLKRQLEEAEEEA----SRANAARRKLQRELDDATE 1065
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 891-1574 9.42e-19

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 94.36  E-value: 9.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   891 RLTRERSQAQADLA-QEKAAKAELEVRLQNtLNEQRVEFAALQEALDhaltekeGKDQELAKLRGQEAAQRTELKELQQT 969
Cdd:TIGR02169  202 RLRREREKAERYQAlLKEKREYEGYELLKE-KEALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQL 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   970 LEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLEtvRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERAS 1049
Cdd:TIGR02169  274 LEELNKKIKDLGEEEQLRVKEKIGELEAEIASLE--RSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1050 R-------AEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAE-------EEWKAQVARGQQEAER 1115
Cdd:TIGR02169  352 RdklteeyAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELdrlqeelQRLSEELADLNAAIAG 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1116 KSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSS---ARAAERSSALREEVQSLRE 1192
Cdd:TIGR02169  432 IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQrelAEAEAQARASEERVRGGRA 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1193 --------------------EVEKQRVIS---------ENLRQELTSQAERAEELGQELKAWQEKFF------QKEQALS 1237
Cdd:TIGR02169  512 veevlkasiqgvhgtvaqlgSVGERYATAievaagnrlNNVVVEDDAVAKEAIELLKRRKAGRATFLplnkmrDERRDLS 591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1238 ALQLEHTSTQA----------------------LVSELLPAKHLCQQLQAEQAAAekrhrEEIEQSKQAAGG-------- 1287
Cdd:TIGR02169  592 ILSEDGVIGFAvdlvefdpkyepafkyvfgdtlVVEDIEAARRLMGKYRMVTLEG-----ELFEKSGAMTGGsraprggi 666

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1288 -----LRAELMRAQRELG----ELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL 1358
Cdd:TIGR02169  667 lfsrsEPAELQRLRERLEglkrELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1359 EvELDQAREKYVQELAAVRTDaethLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEE-RQKLTAQVEELSKKL 1437
Cdd:TIGR02169  747 S-SLEQEIENVKSELKELEAR----IEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEeVSRIEARLREIEQKL 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1438 teydqaSKVQQQKLKAfqaqggesQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKakthydaKKQQNQELQDQLRDL 1517
Cdd:TIGR02169  822 ------NRLTLEKEYL--------EKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE-------LEEELEELEAALRDL 880

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1518 EQ----LQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLR 1574
Cdd:TIGR02169  881 ESrlgdLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKG 941
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 531-1573 7.16e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 91.39  E-value: 7.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   531 QEKAELSQKIEELHACIEAAHQEQRQAQAHVTE----LEAQLKAEQQKVAEREKVmqeKAQLQEQLLALEETLQITKGSL 606
Cdd:pfam01576    8 QAKEEELQKVKERQQKAESELKELEKKHQQLCEeknaLQEQLQAETELCAEAEEM---RARLAARKQELEEILHELESRL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   607 EEEKHRTADALAEQQrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHR 686
Cdd:pfam01576   85 EEEEERSQQLQNEKK----KMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEER 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   687 AESESEQLIREVEswqkRFEARQQEEARYSAMIQEQLAALKGDhEKAGQEAqeEAVEVHGEGQIGEQQSPLAQLHTTLAR 766
Cdd:pfam01576  161 ISEFTSNLAEEEE----KAKSLSKLKNKHEAMISDLEERLKKE-EKGRQEL--EKAKRKLEGESTDLQEQIAELQAQIAE 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   767 ALQQVKEKEvraQKLADDLTTLQEKMAStskvaaclKTLVLKAGEQQEMTSLELLKEppgagnkesnwLEEQRggpfssp 846
Cdd:pfam01576  234 LRAQLAKKE---EELQAALARLEEETAQ--------KNNALKKIRELEAQISELQED-----------LESER------- 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   847 qAALKAMEQEAEQMGSELERLRVALmksqgqqqeergqqerevarltrERSQAQADLAQEKAAKAELEVrlqntlneqrv 926
Cdd:pfam01576  285 -AARNKAEKQRRDLGEELEALKTEL-----------------------EDTLDTTAAQQELRSKREQEV----------- 329

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   927 efAALQEALDHaltEKEGKDQELAKLRGQEAAQrteLKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEA----SAPEAQL 1002
Cdd:pfam01576  330 --TELKKALEE---ETRSHEAQLQEMRQKHTQA---LEELTEQLEQAKRNKANLEKAKQALESENAELQaelrTLQQAKQ 401

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1003 ETVRKTEAPDPEVEALRAEVSkleqqcqqqkqqveglthslESERAsRAEQDKALETLQGQLEEKTQELGHSQAASASAQ 1082
Cdd:pfam01576  402 DSEHKRKKLEGQLQELQARLS--------------------ESERQ-RAELAEKLSKLQSELESVSSLLNEAEGKNIKLS 460

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1083 RELTALHAKAQD-HSKAEEEWKAQVA---RGQQEAERKSSLISSLEEEVSI---LNRQVLEKEGESKELKRLVVAESEKS 1155
Cdd:pfam01576  461 KDVSSLESQLQDtQELLQEETRQKLNlstRLRQLEDERNSLQEQLEEEEEAkrnVERQLSTLQAQLSDMKKKLEEDAGTL 540

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1156 QKLEERLRLLQVETASSSARAAERSSA---LREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQ---ELKAWQEKF 1229
Cdd:pfam01576  541 EALEEGKKRLQRELEALTQQLEEKAAAydkLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQmlaEEKAISARY 620

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1230 F-QKEQALSALQLEHTSTQALVSELLPAKHLcQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQREL-GELGPLRQ 1307
Cdd:pfam01576  621 AeERDRAEAEAREKETRALSLARALEEALEA-KEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALeQQVEEMKT 699

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1308 KVAEQERAAQQLRAEKASYAEQLSMLKKAH--GLLAEENRGLGERANLGRQF--LEVELDQAREKYVQELAAvRTDAETH 1383
Cdd:pfam01576  700 QLEELEDELQATEDAKLRLEVNMQALKAQFerDLQARDEQGEEKRRQLVKQVreLEAELEDERKQRAQAVAA-KKKLELD 778

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1384 LAEMRQ--EAQSTTRELEVMTAKYEGAKVKvleERQRFQEE----RQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQ 1457
Cdd:pfam01576  779 LKELEAqiDAANKGREEAVKQLKKLQAQMK---DLQRELEEarasRDEILAQSKESEKKLKNLEAELLQLQEDLAASERA 855

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1458 GGESQQEVQRLQAQLN--------------ELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKE 1523
Cdd:pfam01576  856 RRQAQQERDELADEIAsgasgksalqdekrRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQK 935

                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1524 NKELRAEAERLGRELQqagLKTKEAEQACR-HLSAQVRSLEAQVAHADQQL 1573
Cdd:pfam01576  936 SESARQQLERQNKELK---AKLQEMEGTVKsKFKSSIAALEAKIAQLEEQL 983
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 2548-2787 8.16e-18

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 85.40  E-value: 8.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2548 IWKLFVAFLIFLTMPFLCIGYWLAPKSRLGHLLKIpvlkfllhsASYLWFLIFLLGESLVMETQ---LSTFKgrsqSVWE 2624
Cdd:pfam00520    3 YFELFILLLILLNTIFLALETYFQPEEPLTTVLEI---------LDYVFTGIFTLEMLLKIIAAgfkKRYFR----SPWN 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2625 ------TSLHMIWVTERSEWrtedpqflaevLFAVTSMLSFTRLAYILPAHESLGTLQI---SIGRMIDDMIRFMFILMI 2695
Cdd:pfam00520   70 ildfvvVLPSLISLVLSSVG-----------SLSGLRVLRLLRLLRLLRLIRRLEGLRTlvnSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2696 ILTAFLCGLNNIYVPYQETEKLGNFNET--------FQFLFWTMFGMEEHTVVDMPQFLVPEFVGRALYGIFTIVMVIVL 2767
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGRTnfdnfpnaFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLL 218

                          250       260
                   ....*....|....*....|
gi 344240178  2768 LNMLIAMITNSFQKIEDDAD 2787
Cdd:pfam00520  219 LNLFIAVIIDNFQELTERTE 238
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 942-1609 1.23e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.50  E-value: 1.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   942 KEGKDQELAKL-RGQEAAQRTE--LKELQQTLEHLKTQLVKKEKEQhpagstggeeasAPEAQLETVRKTEAPDpEVEAL 1018
Cdd:TIGR02168  171 KERRKETERKLeRTRENLDRLEdiLNELERQLKSLERQAEKAERYK------------ELKAELRELELALLVL-RLEEL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1019 RAEVSKLEqqcqqqkQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKA 1098
Cdd:TIGR02168  238 REELEELQ-------EELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1099 EEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLL--QVETASSSARA 1176
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELeeQLETLRSKVAQ 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1177 AERS-SALREEVQSLREEVEKQRVISENLRQELTSQAERAEElgQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLP 1255
Cdd:TIGR02168  391 LELQiASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAELEELEEELEELQEELERLEEALEELRE 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1256 AKHLCQQLQAEQAAAEKRHREEI-------EQSKQAAGGLRAELMRAQRELGELGPLRQKV---AEQERAAQQLRAEKAS 1325
Cdd:TIGR02168  469 ELEEAEQALDAAERELAQLQARLdslerlqENLEGFSEGVKALLKNQSGLSGILGVLSELIsvdEGYEAAIEAALGGRLQ 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1326 YA--EQLSMLKKAHGLLAEENRG------------------LGERANLGRQFLEV------------------------- 1360
Cdd:TIGR02168  549 AVvvENLNAAKKAIAFLKQNELGrvtflpldsikgteiqgnDREILKNIEGFLGVakdlvkfdpklrkalsyllggvlvv 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1361 -ELDQA---REKYVQELAAVRTDAETHL---------AEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1427
Cdd:TIGR02168  629 dDLDNAlelAKKLRPGYRIVTLDGDLVRpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1428 AQVEELSKKLTEYDQASkvqqQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDA----K 1503
Cdd:TIGR02168  709 ELEEELEQLRKELEELS----RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEaeaeI 784

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1504 KQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLK-------TKEAEQACRHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERleslerrIAATERRLEDLEEQIEELSEDIESLAAEIEEL 864

                          730       740       750
                   ....*....|....*....|....*....|....
gi 344240178  1577 GKFQ-VATDALKSREPQKPQLDLSIDSLDLSLEE 1609
Cdd:TIGR02168  865 EELIeELESELEALLNERASLEEALALLRSELEE 898
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 891-1576 1.32e-17

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 90.62  E-value: 1.32e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   891 RLTRERSQAQADLAQEKAAKAELEVRLQNtLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKE----L 966
Cdd:pfam01576  149 KLSKERKLLEERISEFTSNLAEEEEKAKS-LSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEqiaeL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   967 QQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRkteapdpEVEALRAEvskleqqcqqqkqqvegLTHSLESE 1046
Cdd:pfam01576  228 QAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIR-------ELEAQISE-----------------LQEDLESE 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1047 RASRAEQDKALETLQGQLEEKTQELGHSQAASAsAQRELTALHAKAQDHSKA--EEEWKAQVARGQQEAERKSSLISSLE 1124
Cdd:pfam01576  284 RAARNKAEKQRRDLGEELEALKTELEDTLDTTA-AQQELRSKREQEVTELKKalEEETRSHEAQLQEMRQKHTQALEELT 362

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1125 EEVSILNR---------QVLEKEGE--SKELKRLVVAESE---KSQKLEERLRLLQV---ETASSSARAAERSSALREEV 1187
Cdd:pfam01576  363 EQLEQAKRnkanlekakQALESENAelQAELRTLQQAKQDsehKRKKLEGQLQELQArlsESERQRAELAEKLSKLQSEL 442

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1188 QSLR---EEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKeqaLSALQLEHTSTQALVSELLPAKHLCQQLQ 1264
Cdd:pfam01576  443 ESVSsllNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTR---LRQLEDERNSLQEQLEEEEEAKRNVERQL 519

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1265 AEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELgelgplrqkvaeqERAAQQLrAEKASYAEQLsmlKKAHGLLAEEN 1344
Cdd:pfam01576  520 STLQAQLSDMKKKLEEDAGTLEALEEGKKRLQREL-------------EALTQQL-EEKAAAYDKL---EKTKNRLQQEL 582

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1345 RGLGERANLGRQFLEvELDQAREKYVQELAAVRTdAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQ 1424
Cdd:pfam01576  583 DDLLVDLDHQRQLVS-NLEKKQKKFDQMLAEEKA-ISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNK 660

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1425 KLTAQVEELskkLTEYDQASKVQQQKLKAFQAQggesQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKK 1504
Cdd:pfam01576  661 QLRAEMEDL---VSSKDDVGKNVHELERSKRAL----EQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDL 733

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  1505 QQNQELQDQLRdlEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:pfam01576  734 QARDEQGEEKR--RQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLKKL 803
PTZ00121 PTZ00121
MAEBL; Provisional
 1041-1596 2.15e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 90.20  E-value: 2.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1041 HSLESERASRAEQDKALETLQGQLEEKTQElgHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLI 1120
Cdd:PTZ00121 1056 HEGKAEAKAHVGQDEGLKPSYKDFDFDAKE--DNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEA 1133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1121 SSLEEEVSIlnrqvlEKEGESKELKRLVVA-ESEKSQKLEERLRLLQVETASSSARAAERSSAlrEEVQSLRE--EVEKQ 1197
Cdd:PTZ00121 1134 RKAEDARKA------EEARKAEDAKRVEIArKAEDARKAEEARKAEDAKKAEAARKAEEVRKA--EELRKAEDarKAEAA 1205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1198 RVISENLRQELTSQAERAEELgQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHlcQQLQAEQAAAEKRHREE 1277
Cdd:PTZ00121 1206 RKAEEERKAEEARKAEDAKKA-EAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHF--ARRQAAIKAEEARKADE 1282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1278 IEQSKQAAgglRAELMRAQRELGELGPLRQKvAEQERAAQQLRAEKASYAEQLSMLKKAhgllAEENRGLGERANLGRQF 1357
Cdd:PTZ00121 1283 LKKAEEKK---KADEAKKAEEKKKADEAKKK-AEEAKKADEAKKKAEEAKKKADAAKKK----AEEAKKAAEAAKAEAEA 1354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1358 LEVELDQAREKyvQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAK-----VKVLEERQRFQEERQKLTAQV-- 1430
Cdd:PTZ00121 1355 AADEAEAAEEK--AEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkkadeLKKAAAAKKKADEAKKKAEEKkk 1432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1431 -EELSKKLTE----------YDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTH 1499
Cdd:PTZ00121 1433 aDEAKKKAEEakkadeakkkAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA 1512

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1500 YDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGlKTKEAEqacrhlsaQVRSLEAQVAHADQQLRDLGKF 1579
Cdd:PTZ00121 1513 DEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAE-ELKKAE--------EKKKAEEAKKAEEDKNMALRKA 1583

                         570
                  ....*....|....*..
gi 344240178 1580 QVATDALKSREPQKPQL 1596
Cdd:PTZ00121 1584 EEAKKAEEARIEEVMKL 1600
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 674-1535 3.90e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 88.97  E-value: 3.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   674 RRELAEATASQHRAESESEQLIREVEswqkrfEARQQEEaRYSAMIQE---QLAALKGDHEKAG--QEAQEEAVEVHGEG 748
Cdd:TIGR02169  155 RRKIIDEIAGVAEFDRKKEKALEELE------EVEENIE-RLDLIIDEkrqQLERLRREREKAEryQALLKEKREYEGYE 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   749 QIGEQQSPLAQLHTTLAralqQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEppgag 828
Cdd:TIGR02169  228 LLKEKEALERQKEAIER----QLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGE----- 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   829 nkesnwLEEQRggpfSSPQAALKAMEQEAEQMgselerlrvalmksqgqqqeergqqerevarlTRERSQAQADLAQEKA 908
Cdd:TIGR02169  299 ------LEAEI----ASLERSIAEKERELEDA--------------------------------EERLAKLEAEIDKLLA 336

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   909 AKAELEVRLQntlnEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQhpag 988
Cdd:TIGR02169  337 EIEELEREIE----EERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKREL---- 408

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   989 STGGEEASAPEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKT 1068
Cdd:TIGR02169  409 DRLQEELQRLSEELADLNA------AIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVE 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1069 QELghsqaasASAQRELTALHAKAQDHSKAEEEWKAQV----ARGQQEAERKSSLISSLEE-----EVSILNRQ---VLE 1136
Cdd:TIGR02169  483 KEL-------SKLQRELAEAEAQARASEERVRGGRAVEevlkASIQGVHGTVAQLGSVGERyataiEVAAGNRLnnvVVE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1137 KEGESKE----LKR------------------------------------------------------LVVAESEKSQKL 1158
Cdd:TIGR02169  556 DDAVAKEaielLKRrkagratflplnkmrderrdlsilsedgvigfavdlvefdpkyepafkyvfgdtLVVEDIEAARRL 635

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1159 EERLRLLQVET------------ASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQ 1226
Cdd:TIGR02169  636 MGKYRMVTLEGelfeksgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1227 EKffqkeqaLSALQLEhtstqalvsellpakhlcqqlqaeqaaaekrhREEIEQSKQAAGGLRAELMRAQRElgelgpLR 1306
Cdd:TIGR02169  716 RK-------IGEIEKE--------------------------------IEQLEQEEEKLKERLEELEEDLSS------LE 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1307 QKVAEQERAAQQLRAEKASYAEQLSMLKKAhgllaeenrglgeRANLGRQFLEVELDQAREKYvQELAAVRTDAETHLAE 1386
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEA-------------LNDLEARLSHSRIPEIQAEL-SKLEEEVSRIEARLRE 816

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1387 MRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQkltaQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQ 1466
Cdd:TIGR02169  817 IEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEK----EIENLNGKKEELEEELEELEAALRDLESRLGDLKKERD 892

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  1467 RLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLR----------DLEQLQKENKELRAEAERLG 1535
Cdd:TIGR02169  893 ELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGedeeipeeelSLEDVQAELQRVEEEIRALE 971
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
369-793 6.45e-17

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 88.17  E-value: 6.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  369 LSQAKEELEQ-ASQAQGAQLTAQVASLTALNTTLQQQQDQ--ELASLKEQAKKEQAQMVQSLQEQEQAaqglRQQVEQLS 445
Cdd:PRK02224  182 LSDQRGSLDQlKAQIEEKEEKDLHERLNGLESELAELDEEieRYEEQREQARETRDEADEVLEEHEER----REELETLE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  446 SSLKLKEQQLEEAAKDQEAAR---QDHAQQLAIVAEAREASLRE-------RDAARQQLETLEKEKAAKLESLQQQ---L 512
Cdd:PRK02224  258 AEIEDLRETIAETEREREELAeevRDLRERLEELEEERDDLLAEaglddadAEAVEARREELEDRDEELRDRLEECrvaA 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  513 EAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVA-----------EREKV 581
Cdd:PRK02224  338 QAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGdapvdlgnaedFLEEL 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  582 MQEKAQLQEQLLALEETLQITKGSLEEekhrtADALAEQQRCVT-----KMEAESRSLMEQREQEQK---ALEQEKAGRK 653
Cdd:PRK02224  418 REERDELREREAELEATLRTARERVEE-----AEALLEAGKCPEcgqpvEGSPHVETIEEDRERVEEleaELEDLEEEVE 492

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  654 GLEARLQQLEEARQAETEALRRElaeatasqHRAESeSEQLIREveswqKRFEARQQEEARysamiqEQLAALKGDHEKA 733
Cdd:PRK02224  493 EVEERLERAEDLVEAEDRIERLE--------ERRED-LEELIAE-----RRETIEEKRERA------EELRERAAELEAE 552

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  734 GQEAQEEAVEVHGEGQ-----IGEQQSPLAQLHTTLARaLQQVKEKEVRAQKLADDLTTLQEKMA 793
Cdd:PRK02224  553 AEEKREAAAEAEEEAEeareeVAELNSKLAELKERIES-LERIRTLLAAIADAEDEIERLREKRE 616
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1185-1575 1.90e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 86.53  E-value: 1.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1185 EEVQSLREEVEKQRvisenlrQELTSQAERAEELgqelKAWQEKFFQKEQALSALQLEHTSTQAlvsellpakhlcqqlq 1264
Cdd:COG1196   189 ERLEDILGELERQL-------EPLERQAEKAERY----RELKEELKELEAELLLLKLRELEAEL---------------- 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1265 aeqaaaeKRHREEIEQSKQAAGGLRAELMRAQRELGELgplRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1344
Cdd:COG1196   242 -------EELEAELEELEAELEELEAELAELEAELEEL---RLELEELELELEEAQAEEYELLAELARLEQDIARLEERR 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1345 RGLGERAnlgrqfleveldqarekyvQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQ 1424
Cdd:COG1196   312 RELEERL-------------------EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1425 KLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEhyklqmekakthydAKK 1504
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE--------------EEE 438

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178 1505 QQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRD 1575
Cdd:COG1196   439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 136-797 2.09e-16

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 86.56  E-value: 2.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   136 TEKDAQIAMMQQRIDHLALLNE---------KQAASSQESRELEELRGKnesltVRLHETLKQCQNLKTEKNQMDRKISQ 206
Cdd:TIGR00618  227 ELKHLREALQQTQQSHAYLTQKreaqeeqlkKQQLLKQLRARIEELRAQ-----EAVLEETQERINRARKAAPLAAHIKA 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   207 LSEENgdlsfkvrefashlQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELStalqdkkyLEEKNEILQGKLSQlEERAS 286
Cdd:TIGR00618  302 VTQIE--------------QQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSS--------IEEQRRLLQTLHSQ-EIHIR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   287 QQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQ---ARIETLDCERSQQEAQLLAERghfeEEKQQLASLIADLQ 363
Cdd:TIGR00618  359 DAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQslcKELDILQREQATIDTRTSAFR----DLQGQLAHAKKQQE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   364 SSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKK-EQAQMVQSLQEQEQAAQGLRQQVE 442
Cdd:TIGR00618  435 LQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKaVVLARLLELQEEPCPLCGSCIHPN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   443 QLSSSLKLKE-------------QQLEEAAKDQEAARQDHAQQLAIVaEAREASLRERDAARQQLETLEKEKAAKL---- 505
Cdd:TIGR00618  515 PARQDIDNPGpltrrmqrgeqtyAQLETSEEDVYHQLTSERKQRASL-KEQMQEIQQSFSILTQCDNRSKEDIPNLqnit 593

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   506 ESLQQQLEAANEARDSVQTSvTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEReKVMQEK 585
Cdd:TIGR00618  594 VRLQDLTEKLSEAEDMLACE-QHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHAL-SIRVLP 671

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   586 AQLQEQLLALEETLQITKGSLEEEKHRTADALaEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQlEEA 665
Cdd:TIGR00618  672 KELLASRQLALQKMQSEKEQLTYWKEMLAQCQ-TLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLK-ELM 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   666 RQAETEALRRELAEATASQH-----RAESESEQLIREVESWQKRFEARQQEEARYSAMIQeqlaalkgdhEKAGQEAQEE 740
Cdd:TIGR00618  750 HQARTVLKARTEAHFNNNEEvtaalQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIG----------QEIPSDEDIL 819

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178   741 AVEVHGEGQIGEQ-QSPLAQLHTTLARALQQVKEKEVRAQKLaDDLTTLQEKMASTSK 797
Cdd:TIGR00618  820 NLQCETLVQEEEQfLSRLEEKSATLGEITHQLLKYEECSKQL-AQLTQEQAKIIQLSD 876
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 406-1224 2.65e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 86.18  E-value: 2.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   406 DQELASLKEQAKKEQAQMvQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQlAIVAEAREASLR 485
Cdd:pfam02463  159 EEEAAGSRLKRKKKEALK-KLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEE-YLLYLDYLKLNE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   486 ERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELhacIEAAHQEQRQAQAHVTELE 565
Cdd:pfam02463  237 ERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKE---EEELKSELLKLERRKVDDE 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   566 AQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKAL 645
Cdd:pfam02463  314 EKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLK 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   646 EQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAA 725
Cdd:pfam02463  394 EEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDL 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   726 LKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLhttLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACL--- 802
Cdd:pfam02463  474 LKETQLVKLQEQLELLLSRQKLEERSQKESKARSG---LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTavi 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   803 ----KTLVLKAGEQQEMTSLELLKEPPG--AGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQG 876
Cdd:pfam02463  551 vevsATADEVEERQKLVRALTELPLGARklRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILK 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   877 QQQEERGQQErevARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLrgqe 956
Cdd:pfam02463  631 DTELTKLKES---AKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKK---- 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   957 AAQRTELKELQQTLEHLKTQLVKKEKEQHPAgstggEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQV 1036
Cdd:pfam02463  704 KEQREKEELKKLKLEAEELLADRVQEAQDKI-----NEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAE 778

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1037 EglthsLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERK 1116
Cdd:pfam02463  779 E-----REKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAE 853

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1117 SSLISSLEE-EVSILNRQVLEKEGESKELK---RLVVAESEKSQKLEERLRLLQVETA--SSSARAAERSSALREEVQSL 1190
Cdd:pfam02463  854 EELERLEEEiTKEELLQELLLKEEELEEQKlkdELESKEEKEKEEKKELEEESQKLNLleEKENEIEERIKEEAEILLKY 933

                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 344240178  1191 REEVEK---QRVISENLRQELTSQAERAEELGQELKA 1224
Cdd:pfam02463  934 EEEPEElllEEADEKEKEENNKEEEEERNKRLLLAKE 970
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 137-700 4.89e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 85.56  E-value: 4.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   137 EKDAQIAMMQQRI----DHLALL-----NEKQAASSQESRELEELRGKNE----SLTVRLHETLKQCQNLKTE------- 196
Cdd:pfam15921  228 ELDTEISYLKGRIfpveDQLEALksesqNKIELLLQQHQDRIEQLISEHEveitGLTEKASSARSQANSIQSQleiiqeq 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   197 -KNQMDRKISQLSeengDLSFKVREFASHLQQLQGAFNDLTEEHNK----ASQEWAEKQThlekELSTALQDKKYLEEKN 271
Cdd:pfam15921  308 aRNQNSMYMRQLS----DLESTVSQLRSELREAKRMYEDKIEELEKqlvlANSELTEART----ERDQFSQESGNLDDQL 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   272 EILQGKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCE-RSQQEAQLLAERGHfEE 350
Cdd:pfam15921  380 QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSEcQGQMERQMAAIQGK-NE 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   351 EKQQLASLIADLQSSISNLSQAKEELeqasqaqgaqltaqvaslTALNTTLqqqqdqelaslkEQAKKEQAQMVQSLQEQ 430
Cdd:pfam15921  459 SLEKVSSLTAQLESTKEMLRKVVEEL------------------TAKKMTL------------ESSERTVSDLTASLQEK 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   431 EQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDqeaarQDHAQQLAIVAEAREASLRERDaarQQLETLEKEkaakLESLQQ 510
Cdd:pfam15921  509 ERAIEATNAEITKLRSRVDLKLQELQHLKNE-----GDHLRNVQTECEALKLQMAEKD---KVIEILRQQ----IENMTQ 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   511 QLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQ-----------LKAEQQKVAERE 579
Cdd:pfam15921  577 LVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEkvklvnagserLRAVKDIKQERD 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   580 KVMQEKAQLQEQLLALEETLQITKGSLE---EEKHRTADALAEQQRCVTKMEAESRSLMEQRE-QEQKALEQEKAGRKGL 655
Cdd:pfam15921  657 QLLNEVKTSRNELNSLSEDYEVLKRNFRnksEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEgSDGHAMKVAMGMQKQI 736

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*
gi 344240178   656 EARLQQLeEARQAETEALRRELAEATASQHRAESESEQLIREVES 700
Cdd:pfam15921  737 TAKRGQI-DALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELST 780
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
293-774 1.44e-15

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 83.81  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  293 AQEKGEVLGdalQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERghfeeekqqlasliadlqssISNLSQA 372
Cdd:COG4913   247 AREQIELLE---PIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAE--------------------LEELRAE 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  373 KEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKeqakKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKE 452
Cdd:COG4913   304 LARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLE----REIERLERELEERERRRARLEALLAALGLPLPASA 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  453 QQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKA----------AKLESLQQQLE--------- 513
Cdd:COG4913   380 EEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIAslerrksnipARLLALRDALAealgldeae 459

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  514 ----------------------------------------AANEARDS-----------VQTSVTQVQQEKAE---LSQK 539
Cdd:COG4913   460 lpfvgelievrpeeerwrgaiervlggfaltllvppehyaAALRWVNRlhlrgrlvyerVRTGLPDPERPRLDpdsLAGK 539

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  540 IE------------EL-----HACIEAAHQEQRQAQAhVTeLEAQLKAE----------------------QQKVAEREk 580
Cdd:COG4913   540 LDfkphpfrawleaELgrrfdYVCVDSPEELRRHPRA-IT-RAGQVKGNgtrhekddrrrirsryvlgfdnRAKLAALE- 616

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  581 vmQEKAQLQEQLLALEETLQITKGSLE--EEKHRTADALAEQQRcvtkMEAESRSLMEQREQEQKALEQEKAGRKGLEAr 658
Cdd:COG4913   617 --AELAELEEELAEAEERLEALEAELDalQERREALQRLAEYSW----DEIDVASAEREIAELEAELERLDASSDDLAA- 689

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  659 LQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVEswqkrfEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQ 738
Cdd:COG4913   690 LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD------ELQDRLEAAEDLARLELRALLEERFAAALGDAV 763

                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 344240178  739 EEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEK 774
Cdd:COG4913   764 ERELRENLEERIDALRARLNRAEEELERAMRAFNRE 799
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
222-773 1.56e-15

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 83.81  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  222 ASHLQQLQGAFNDLTEEHnkASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQcespaqeKGEVLG 301
Cdd:COG4913   271 LAELEYLRAALRLWFAQR--RLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGN-------GGDRLE 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  302 D-ALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSsisNLSQAKEELEQAs 380
Cdd:COG4913   342 QlEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEE---ALAEAEAALRDL- 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  381 QAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQM------VQSLQEQEQ---AAQG-LRQQ---------- 440
Cdd:COG4913   418 RRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAELpfvgelIEVRPEEERwrgAIERvLGGFaltllvppeh 497

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  441 -------VEQLSSSLKLKEQQLEEAAKDQEAARQDH---AQQLAI----VAEAREASLRERDAAR-----QQLETLEK-- 499
Cdd:COG4913   498 yaaalrwVNRLHLRGRLVYERVRTGLPDPERPRLDPdslAGKLDFkphpFRAWLEAELGRRFDYVcvdspEELRRHPRai 577

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  500 -------------EK----------------AAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAA 550
Cdd:COG4913   578 tragqvkgngtrhEKddrrrirsryvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYS 657

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  551 HQEQ--RQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCvtkme 628
Cdd:COG4913   658 WDEIdvASAEREIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDEL----- 732

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  629 aesrslmeQREQEQKALEQEKAGRKGLEARLQQL--EEARQAETEALRRELAEATASQHRAEsesEQLIREVESWQKRFE 706
Cdd:COG4913   733 --------QDRLEAAEDLARLELRALLEERFAAAlgDAVERELRENLEERIDALRARLNRAE---EELERAMRAFNREWP 801

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178  707 ARQQE---EARYSAMIQEQLAALKGD----HEKAGQEAQEEAVEVHgegqigeqqspLAQLHTTLARALQQVKE 773
Cdd:COG4913   802 AETADldaDLESLPEYLALLDRLEEDglpeYEERFKELLNENSIEF-----------VADLLSKLRRAIREIKE 864
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
96-722 1.94e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 83.19  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   96 MGDILQTPQFQMRRLKKQLADERNNRDELElelseslklltEKDAQIAMMQQRIDHLAL----LNEKQAASSQESRELEE 171
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTENIEELIK-----------EKEKELEEVLREINEISSelpeLREELEKLEKEVKELEE 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  172 LRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFAShLQQLQGAFNDLTEEHNKASQEWAEkqt 251
Cdd:PRK03918  236 LKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELRE--- 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  252 hLEKELSTALQDKKYLEEKNEILQGKLSQLEErASQQCESPAQEKGEVLGDALQLETLKQEAAKLaahnTQLQARIETLD 331
Cdd:PRK03918  312 -IEKRLSRLEEEINGIEERIKELEEKEERLEE-LKKKLKELEKRLEELEERHELYEEAKAKKEEL----ERLKKRLTGLT 385

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  332 CERSQQEAQLLAERG-HFEEEKQQLASLIADLQSSISNLSQAKEELEQASQ---AQGAQLTAQ-----VASLTALNTTLQ 402
Cdd:PRK03918  386 PEKLEKELEELEKAKeEIEEEISKITARIGELKKEIKELKKAIEELKKAKGkcpVCGRELTEEhrkelLEEYTAELKRIE 465

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  403 QQQdQELASLKEQAKKEQAQmVQSLQEQEQAAQGLRQQVEQLSS-SLKLKEQQLEEAAKDQEAARQdhaqqlaivaeare 481
Cdd:PRK03918  466 KEL-KEIEEKERKLRKELRE-LEKVLKKESELIKLKELAEQLKElEEKLKKYNLEELEKKAEEYEK-------------- 529

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  482 asLRER-DAARQQLETLEKEkAAKLESLQQQLEAANEARDSvqtsvtqVQQEKAELSQKIEEL-HACIEAAHQEQRQAQA 559
Cdd:PRK03918  530 --LKEKlIKLKGEIKSLKKE-LEKLEELKKKLAELEKKLDE-------LEEELAELLKELEELgFESVEELEERLKELEP 599

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  560 HVTELEAQLKAEQQKvaEREKVMQEKaqLQEQLLALEETLQITKGSLEEEKHRtadaLAEQQRcvtkmeaeSRSLMEQRE 639
Cdd:PRK03918  600 FYNEYLELKDAEKEL--EREEKELKK--LEEELDKAFEELAETEKRLEELRKE----LEELEK--------KYSEEEYEE 663

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  640 QEQKALEQEKAgRKGLEARLQQLEEARQaETEALRRELAEATASQHRAESESEQLirevESWQKRFEARQQEEARYSAMI 719
Cdd:PRK03918  664 LREEYLELSRE-LAGLRAELEELEKRRE-EIKKTLEKLKEELEEREKAKKELEKL----EKALERVEELREKVKKYKALL 737


                  ...
gi 344240178  720 QEQ 722
Cdd:PRK03918  738 KER 740
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 203-981 2.30e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 83.09  E-value: 2.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   203 KISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQDKKYLEEKneiLQGKLSQLE 282
Cdd:TIGR00618  177 QYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAY---LTQKREAQE 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   283 ERASQQcespaQEKGEVLGdalQLETLKQEAAKLAAHNTQLqarietldcERSQQEAQLLAERGHFEEEKQQLASLIADL 362
Cdd:TIGR00618  254 EQLKKQ-----QLLKQLRA---RIEELRAQEAVLEETQERI---------NRARKAAPLAAHIKAVTQIEQQAQRIHTEL 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   363 QSSISNLSQAKEElEQASQAQGAQLTAQVASLTALNTT--LQQQQDQELASLKEQAKKEQA--QMVQSLQEQEQAAqglr 438
Cdd:TIGR00618  317 QSKMRSRAKLLMK-RAAHVKQQSSIEEQRRLLQTLHSQeiHIRDAHEVATSIREISCQQHTltQHIHTLQQQKTTL---- 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   439 QQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRerdaarqQLETLEKEKAAKLESLQQQLEAANEA 518
Cdd:TIGR00618  392 TQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQR-------YAELCAAAITCTAQCEKLEKIHLQES 464

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   519 RDSVQTSVTQVQQeKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEET 598
Cdd:TIGR00618  465 AQSLKEREQQLQT-KEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETS 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   599 LQITKGSLEEEkhrtadalaeqqrcvTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELA 678
Cdd:TIGR00618  544 EEDVYHQLTSE---------------RKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAED 608

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   679 EATASQHRaesESEQLIREVESWQKRFEARQQEEArysamIQEQLAALKGDHEKAGQEAQEEAvevhgegqigeqqspLA 758
Cdd:TIGR00618  609 MLACEQHA---LLRKLQPEQDLQDVRLHLQQCSQE-----LALKLTALHALQLTLTQERVREH---------------AL 665

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   759 QLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELlkeppgagnkesnwleeq 838
Cdd:TIGR00618  666 SIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENAS------------------ 727

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   839 rggpfSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQ 918
Cdd:TIGR00618  728 -----SSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLK 802

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178   919 NTLNEqrvefaaLQEALDHALTEKEGKDQELAKlrgQEAAQRTELKELQQTLEHLKTQLVKKE 981
Cdd:TIGR00618  803 TLEAE-------IGQEIPSDEDILNLQCETLVQ---EEEQFLSRLEEKSATLGEITHQLLKYE 855
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1275-1576 2.56e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 83.06  E-value: 2.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1275 REEIEQSKQAAGGLRAELMRAQRELgelgpLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERanlg 1354
Cdd:COG1196   219 KEELKELEAELLLLKLRELEAELEE-----LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAE---- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1355 rqflEVELDQAREKYVQELAavrtdaetHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELS 1434
Cdd:COG1196   290 ----EYELLAELARLEQDIA--------RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1435 KKLteyDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQL 1514
Cdd:COG1196   358 AEL---AEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1515 RDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:COG1196   435 EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
283-694 2.99e-15

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 82.12  E-value: 2.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  283 ERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLdcERSQQEAQLLAERGHFEEEKQQLASLIADL 362
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL--EKLLQLLPLYQELEALEAELAELPERLEEL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  363 QSSISNLSQAKEELEQASQAQgAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVE 442
Cdd:COG4717   152 EERLEELRELEEELEELEAEL-AELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  443 QLSSSLKL--KEQQLEEA----------------AKDQEAARQDHAQQLAIVAEA----------REASLRERDAARQQL 494
Cdd:COG4717   231 QLENELEAaaLEERLKEArlllliaaallallglGGSLLSLILTIAGVLFLVLGLlallflllarEKASLGKEAEELQAL 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  495 ETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQ----AHVT---ELEAQ 567
Cdd:COG4717   311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAllaeAGVEdeeELRAA 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  568 LKAEQQKVAEREKVMQEKAQLQEQLLALEETL-QITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLmeqrEQEQKALE 646
Cdd:COG4717   391 LEQAEEYQELKEELEELEEQLEELLGELEELLeALDEEELEEELEELEEELEELEEELEELREELAEL----EAELEQLE 466

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 344240178  647 QEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQL 694
Cdd:COG4717   467 EDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERL 514
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 418-1115 3.37e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 82.71  E-value: 3.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   418 KEQAQMVQSLQEQEQAAQ----------GLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEArEASLRER 487
Cdd:TIGR00618  163 KEKKELLMNLFPLDQYTQlalmefakkkSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREA-LQQTQQS 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   488 DAARQQLETLEKEKAAKLESLQQQLEAANEARDsvQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQ 567
Cdd:TIGR00618  242 HAYLTQKREAQEEQLKKQQLLKQLRARIEELRA--QEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   568 LKAEQQKVAEREKVMQEKAQLQEQlLALEETLQitkgSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQ 647
Cdd:TIGR00618  320 MRSRAKLLMKRAAHVKQQSSIEEQ-RRLLQTLH----SQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQK 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   648 EKAGRKGLEA--RLQQLEEARQAETEALRRELAEATAS---QHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQ 722
Cdd:TIGR00618  395 LQSLCKELDIlqREQATIDTRTSAFRDLQGQLAHAKKQqelQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQ 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   723 LAALKGDHEkagQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEV---RAQKLADDLTTLQEKMASTSKVA 799
Cdd:TIGR00618  475 LQTKEQIHL---QETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPltrRMQRGEQTYAQLETSEEDVYHQL 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   800 ACLKTLV--LKAGEQQEMTSLELLKEPPGAGNKESNWL--EEQRGGPFSSPQAALKAMEQEAEQmgSELERLRVALMKSQ 875
Cdd:TIGR00618  552 TSERKQRasLKEQMQEIQQSFSILTQCDNRSKEDIPNLqnITVRLQDLTEKLSEAEDMLACEQH--ALLRKLQPEQDLQD 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   876 GQQQEERGQQEREVARLTRERSqaQADLAQEKAAKAELEVRLQNTLNEQRVEFA--ALQEALDHALTEKEGKDQELAKLR 953
Cdd:TIGR00618  630 VRLHLQQCSQELALKLTALHAL--QLTLTQERVREHALSIRVLPKELLASRQLAlqKMQSEKEQLTYWKEMLAQCQTLLR 707

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   954 GQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGE-EASAPEAQLETVRKTEAPDPEV---EALRAEVSKLEQQC 1029
Cdd:TIGR00618  708 ELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKElMHQARTVLKARTEAHFNNNEEVtaaLQTGAELSHLAAEI 787

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1030 QQQKQQVEGLTHSL---ESERASRAEQDKALETLQGQLEEKTQELGHSQAASASA-QRELTALHAKAQDHSKAEEEWKAQ 1105
Cdd:TIGR00618  788 QFFNRLREEDTHLLktlEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSAtLGEITHQLLKYEECSKQLAQLTQE 867

                          730
                   ....*....|
gi 344240178  1106 VARGQQEAER 1115
Cdd:TIGR00618  868 QAKIIQLSDK 877
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 106-790 4.15e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 82.42  E-value: 4.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   106 QMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDhlallnEKQAASSQESRELEELRGKNESLTVRLhe 185
Cdd:TIGR02169  288 EQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEID------KLLAEIEELEREIEEERKRRDKLTEEY-- 359

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   186 tlkqcQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNK---ASQEWAEKQTHLEKELSTALQ 262
Cdd:TIGR02169  360 -----AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRlqeELQRLSEELADLNAAIAGIEA 434

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   263 DKKYLEEKNEILQGKLSQLEERASQQCEspaqekgevlgdalQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLL 342
Cdd:TIGR02169  435 KINELEEEKEDKALEIKKQEWKLEQLAA--------------DLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQAR 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   343 AERGHFEEEKQQLASLIADLQS---SISNLSQAKEELEQASQ-AQGAQLTAQV---------------------ASLTAL 397
Cdd:TIGR02169  501 ASEERVRGGRAVEEVLKASIQGvhgTVAQLGSVGERYATAIEvAAGNRLNNVVveddavakeaiellkrrkagrATFLPL 580

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   398 NTTLQQQQDQELASLK---------------------------------EQAKKE--QAQMVQ---SLQEQEQAAQG--- 436
Cdd:TIGR02169  581 NKMRDERRDLSILSEDgvigfavdlvefdpkyepafkyvfgdtlvvediEAARRLmgKYRMVTlegELFEKSGAMTGgsr 660

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   437 LRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEkaakLESLQQQLEAAN 516
Cdd:TIGR02169  661 APRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKE----IEQLEQEEEKLK 736

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   517 EARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAE--QQKVAEREKVMQEKAQLQEQLLA 594
Cdd:TIGR02169  737 ERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSriPEIQAELSKLEEEVSRIEARLRE 816

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   595 LEETLQitkgSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEarqaETEALR 674
Cdd:TIGR02169  817 IEQKLN----RLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLES----RLGDLK 888

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   675 RELAEATASQHRAESESEQLIREVEswQKRFEARQQEEARysAMIQEQLAALkgdhEKAGQEAQEEAVEVHGEGQIGEQQ 754
Cdd:TIGR02169  889 KERDELEAQLRELERKIEELEAQIE--KKRKRLSELKAKL--EALEEELSEI----EDPKGEDEEIPEEELSLEDVQAEL 960

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|
gi 344240178   755 SPLAQLHTTLA----RALQQVKEKEVRAQKLADDLTTLQE 790
Cdd:TIGR02169  961 QRVEEEIRALEpvnmLAIQEYEEVLKRLDELKEKRAKLEE 1000
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
136-593 5.04e-15

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 81.35  E-value: 5.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  136 TEKDAQIAMMQQRIDHLALLNEKQAASSQESRELEELRGKNESLT--VRLHETLKQCQNLKTEKNQMDRKISQLSEENGD 213
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELReeLEKLEKLLQLLPLYQELEALEAELAELPERLEE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  214 LSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQqcespA 293
Cdd:COG4717   151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEE-----L 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  294 QEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIEtldcersqqeaqLLAERGHFEEEKQQLASLIADLQSSISNLSQAK 373
Cdd:COG4717   226 EEELEQLENELEAAALEERLKEARLLLLIAAALLA------------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLL 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  374 EELEQASQAQGAQLTAQVASltalnTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQ 453
Cdd:COG4717   294 AREKASLGKEAEELQALPAL-----EELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEEL 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  454 QLEEAAKDQEAARQDHAQ--QLAIVAEAREASLRERDAARQQLETLEKE-----KAAKLESLQQQLEAANEARDSVQTSV 526
Cdd:COG4717   369 EQEIAALLAEAGVEDEEElrAALEQAEEYQELKEELEELEEQLEELLGEleellEALDEEELEEELEELEEELEELEEEL 448

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  527 TQVQQEKAELSQKIEELHACIEAAHQEQRQAQAhVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLL 593
Cdd:COG4717   449 EELREELAELEAELEQLEEDGELAELLQELEEL-KAELRELAEEWAALKLALELLEEAREEYREERL 514
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1302-1598 6.16e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.52  E-value: 6.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1302 LGPLRQKvAEQERAAQQLRAEKASYaEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA-REKYVQELAAVRTDA 1380
Cdd:COG1196   202 LEPLERQ-AEKAERYRELKEELKEL-EAELLLLKLRELEAELEELEAELEELEAELEELEAELAeLEAELEELRLELEEL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1381 ETHLAEMRQEAQSTTRELEvmtaKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGE 1460
Cdd:COG1196   280 ELELEEAQAEEYELLAELA----RLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1461 SQQEVQRLQAQLNELQTQLSQKEQA-AEHYKLQMEKAKTHYDAKKQQNQ---ELQDQLRDLEQLQKENKELRAEAERLGR 1536
Cdd:COG1196   356 AEAELAEAEEALLEAEAELAEAEEElEELAEELLEALRAAAELAAQLEEleeAEEALLERLERLEEELEELEEALAELEE 435

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1537 ELQQAglKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQKPQLDL 1598
Cdd:COG1196   436 EEEEE--EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1158-1585 8.79e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.14  E-value: 8.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1158 LEERLRLLQVEtasssARAAERSSALREEVQSLREEVEKQRVisENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1237
Cdd:COG1196   198 LERQLEPLERQ-----AEKAERYRELKEELKELEAELLLLKL--RELEAELEELEAELEELEAELEELEAELAELEAELE 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1238 ALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELgplrqkVAEQERAAQ 1317
Cdd:COG1196   271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEEL------EEELEELEE 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1318 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREkyvqelAAVRTDAETHLAEMRQEAQSTTRE 1397
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA------AAELAAQLEELEEAEEALLERLER 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1398 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQT 1477
Cdd:COG1196   419 LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1478 QLSQKEQAAEHYKLQMEKAKTHYDAK------------------------KQQNQELQDQLRDLEQLQKENKELRAEAER 1533
Cdd:COG1196   499 AEADYEGFLEGVKAALLLAGLRGLAGavavligveaayeaaleaalaaalQNIVVEDDEVAAAAIEYLKAAKAGRATFLP 578

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1534 LGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDA 1585
Cdd:COG1196   579 LDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAA 630
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 218-976 9.24e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 81.32  E-value: 9.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   218 VREFASHLQQLQGAFNDLTEEHNKasQEWAEKQTHLEkeLSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQE-- 295
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELHEK--QKFYLRQSVID--LQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHEle 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   296 -----KGEVLGDA-LQLETLKQeaaKLAAHNTQLQaRIETLDCERSQQEAQLLAERG-----HFEEEKQQLASLIADLQS 364
Cdd:pfam15921  156 aakclKEDMLEDSnTQIEQLRK---MMLSHEGVLQ-EIRSILVDFEEASGKKIYEHDsmstmHFRSLGSAISKILRELDT 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   365 SISNLSQAKEELEQASQAQGAQltaqvaSLTALNTTLQQQQDQ----------ELASLKEQAK--KEQAQMVQSLQE--Q 430
Cdd:pfam15921  232 EISYLKGRIFPVEDQLEALKSE------SQNKIELLLQQHQDRieqlisehevEITGLTEKASsaRSQANSIQSQLEiiQ 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   431 EQAAQG---LRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQ-------QLETL--- 497
Cdd:pfam15921  306 EQARNQnsmYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQesgnlddQLQKLlad 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   498 --EKEKAAKLESLQQQLEAANEARDSVqtSVTQVQQEKAELSQKIEELHACIEAAHQEQRqaqahvTELEAQLKAEQQKV 575
Cdd:pfam15921  386 lhKREKELSLEKEQNKRLWDRDTGNSI--TIDHLRRELDDRNMEVQRLEALLKAMKSECQ------GQMERQMAAIQGKN 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   576 AEREKVMQEKAQLQ---EQLLALEETLQITKGSLEEEKHRTAD---ALAEQQRCVTKMEAES---RSLMEQREQEQKALE 646
Cdd:pfam15921  458 ESLEKVSSLTAQLEstkEMLRKVVEELTAKKMTLESSERTVSDltaSLQEKERAIEATNAEItklRSRVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   647 QEkagrkglEARLQQLeearQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAAL 726
Cdd:pfam15921  538 NE-------GDHLRNV----QTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLEL 606

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   727 KgdhEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLV 806
Cdd:pfam15921  607 Q---EFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNF 683

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   807 LKAGEQQEMTSLELLKEPPGAGNKesnwLEEQRGgpfsspqaALKAMEqeaeqmGSELERLRVALMKSQgqqqeergqqe 886
Cdd:pfam15921  684 RNKSEEMETTTNKLKMQLKSAQSE----LEQTRN--------TLKSME------GSDGHAMKVAMGMQK----------- 734

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   887 revaRLTRERSQAQAdlaqekaakaelevrLQNtlneqRVEFaaLQEALDHALTEKEGKDQELAKLRGQEAAQRTELKEL 966
Cdd:pfam15921  735 ----QITAKRGQIDA---------------LQS-----KIQF--LEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKM 788

                          810
                   ....*....|
gi 344240178   967 QQTLEHLKTQ 976
Cdd:pfam15921  789 AGELEVLRSQ 798
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 137-868 1.21e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 80.93  E-value: 1.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   137 EKDAQIAMMQQRIDHLALLNEKQAASSQES-----RELEELRGKNESLT-VRLHETlkqcQNLKTEKNQMDRKISQL--- 207
Cdd:pfam15921   82 EYSHQVKDLQRRLNESNELHEKQKFYLRQSvidlqTKLQEMQMERDAMAdIRRRES----QSQEDLRNQLQNTVHELeaa 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   208 --------SEENGDLSFKVREFASH---LQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQdkKYLEEkneiLQG 276
Cdd:pfam15921  158 kclkedmlEDSNTQIEQLRKMMLSHegvLQEIRSILVDFEEASGKKIYEHDSMSTMHFRSLGSAIS--KILRE----LDT 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   277 KLSQLeerasqqcespaqeKGEVLGDALQLETLKQEAaklaahntqlQARIETLDCERSQQEAQLLAERghfEEEKQQLA 356
Cdd:pfam15921  232 EISYL--------------KGRIFPVEDQLEALKSES----------QNKIELLLQQHQDRIEQLISEH---EVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   357 SLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQ-------QDQELASLKEQAKKEQAQMVQSLQE 429
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSElreakrmYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   430 QEQAAQ---GLRQQVEQLSSSLKLKEQQLE-EAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQ--LETLEKEKAA 503
Cdd:pfam15921  365 RDQFSQesgNLDDQLQKLLADLHKREKELSlEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEalLKAMKSECQG 444

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   504 KLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQaqahVTELEAQLKAEQQKVaerEKVMQ 583
Cdd:pfam15921  445 QMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT----VSDLTASLQEKERAI---EATNA 517

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   584 EKAQLQEQL-LALEEtLQITKGslEEEKHRTADALAEQQRCvtkMEAESRSLMEQREQEQKALEQeKAGRKGLEARLQQL 662
Cdd:pfam15921  518 EITKLRSRVdLKLQE-LQHLKN--EGDHLRNVQTECEALKL---QMAEKDKVIEILRQQIENMTQ-LVGQHGRTAGAMQV 590

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   663 EEAR-QAETEALRRELAEATASQHRAESEseqlIREVESwqkRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEA 741
Cdd:pfam15921  591 EKAQlEKEINDRRLELQEFKILKDKKDAK----IRELEA---RVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVK 663

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   742 VEVHGEGQIGEQQSPLA--------QLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACL-KTLVLKAGEQ 812
Cdd:pfam15921  664 TSRNELNSLSEDYEVLKrnfrnkseEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMqKQITAKRGQI 743

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178   813 QEMTS-LELLKEPPGAGNKESNWLEEQRggpfSSPQAALKAMEQEAEQMGSELERLR 868
Cdd:pfam15921  744 DALQSkIQFLEEAMTNANKEKHFLKEEK----NKLSQELSTVATEKNKMAGELEVLR 796
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 413-1350 1.26e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 80.88  E-value: 1.26e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   413 KEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQ 492
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   493 QLETLEK---EKAAKLESLQQQLEAANEA-RDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQL 568
Cdd:TIGR02169  252 ELEKLTEeisELEKRLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEI 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   569 KAEQQKVAEREKVMQE----KAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEA----------ESRSL 634
Cdd:TIGR02169  332 DKLLAEIEELEREIEEerkrRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKlkreinelkrELDRL 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   635 MEQREQEQKALEQEKAGRKGLEARLQQLEEAR---QAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQE 711
Cdd:TIGR02169  412 QEELQRLSEELADLNAAIAGIEAKINELEEEKedkALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   712 ----EARYSAMIQEQlaalkgdhekAGQEAQEEAVEVHGEGQIGeqqsplaqlhttLARALQQVKEKEVRAQKLADDlTT 787
Cdd:TIGR02169  492 laeaEAQARASEERV----------RGGRAVEEVLKASIQGVHG------------TVAQLGSVGERYATAIEVAAG-NR 548

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   788 LQEKMASTSKVAAclktlvlkageqqemTSLELLKEppgagnkesnwleeQRGGPFSS-PQAALKAMEQEAEqMGSELER 866
Cdd:TIGR02169  549 LNNVVVEDDAVAK---------------EAIELLKR--------------RKAGRATFlPLNKMRDERRDLS-ILSEDGV 598

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   867 LRVALmksqgqqqeergqqerevarltrersqaqaDLAQ--EKAAKAELEVrLQNTLNEQRVEFAALQE------ALDHA 938
Cdd:TIGR02169  599 IGFAV------------------------------DLVEfdPKYEPAFKYV-FGDTLVVEDIEAARRLMgkyrmvTLEGE 647

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   939 LTEKEGK----DQELAKLRGQEAAQRTELKELQQTLEHLKTQLvkkekeqhpagstggeeasapeaqletvrkteapdpe 1014
Cdd:TIGR02169  648 LFEKSGAmtggSRAPRGGILFSRSEPAELQRLRERLEGLKREL------------------------------------- 690

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1015 vEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQD 1094
Cdd:TIGR02169  691 -SSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEE 769

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1095 HSKAEEEWKAQVArgqqeaerksslisslEEEVSILNRQVLEKEGESKELKrlvvaesEKSQKLEERLRLLQVETASSSA 1174
Cdd:TIGR02169  770 LEEDLHKLEEALN----------------DLEARLSHSRIPEIQAELSKLE-------EEVSRIEARLREIEQKLNRLTL 826

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1175 RAAerssALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELL 1254
Cdd:TIGR02169  827 EKE----YLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELE 902

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1255 PAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRA----------EKA 1324
Cdd:TIGR02169  903 RKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRAlepvnmlaiqEYE 982

                          970       980
                   ....*....|....*....|....*.
gi 344240178  1325 SYAEQLSMLKKAHGLLAEENRGLGER 1350
Cdd:TIGR02169  983 EVLKRLDELKEKRAKLEEERKAILER 1008
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 137-793 1.31e-14

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 80.65  E-value: 1.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   137 EKDAQIAMMQQRIDHLALLNEKQAASSQESReLEELRGKNESLTVRLHETLKQCQNLKTEKNQ----MDRKISQLSEE-N 211
Cdd:pfam12128  229 DIQAIAGIMKIRPEFTKLQQEFNTLESAELR-LSHLHFGYKSDETLIASRQEERQETSAELNQllrtLDDQWKEKRDElN 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   212 GDLSF---KVREFASHLQQLQ---GAFNDLTEEHNKASQE----WAEKQTHLEKELstalqdkKYLEEKNEILQGKLSQL 281
Cdd:pfam12128  308 GELSAadaAVAKDRSELEALEdqhGAFLDADIETAAADQEqlpsWQSELENLEERL-------KALTGKHQDVTAKYNRR 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   282 EERASQQCespaqeKGEVLGDALQLETLKQEAAKLAAhntQLQARIETLDCE-RSQQEAQLLaergHFEEEKQQLASLIA 360
Cdd:pfam12128  381 RSKIKEQN------NRDIAGIKDKLAKIREARDRQLA---VAEDDLQALESElREQLEAGKL----EFNEEEYRLKSRLG 447

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   361 DLQSSISNLSQAKEELEQASQAQGAQLTAQVAsLTALNTTLQQQQDQELA--SLKEQAKKEQAQMVQSLQEQEQAAQGLR 438
Cdd:pfam12128  448 ELKLRLNQATATPELLLQLENFDERIERAREE-QEAANAEVERLQSELRQarKRRDQASEALRQASRRLEERQSALDELE 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   439 QQ--------VEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETleKEKAAKLESLQQ 510
Cdd:pfam12128  527 LQlfpqagtlLHFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDV--PEWAASEEELRE 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   511 QLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKvmQEKAQLQE 590
Cdd:pfam12128  605 RLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALA--ERKDSANE 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   591 QLLALEetlqitkGSLEEEKHRTADALAEQQRcvtkmeaESRSLMEQREQEQKALEQEkagRKGLEARLQQLEEARQ--- 667
Cdd:pfam12128  683 RLNSLE-------AQLKQLDKKHQAWLEEQKE-------QKREARTEKQAYWQVVEGA---LDAQLALLKAAIAARRsga 745

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   668 -AETEALRRELAEATASQHRAESESEQLIREVESWQKRFE---ARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVE 743
Cdd:pfam12128  746 kAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIEriaVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISE 825

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 344240178   744 VhgEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMA 793
Cdd:pfam12128  826 L--QQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLA 873
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 99-701 1.69e-14

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 80.40  E-value: 1.69e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    99 ILQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTekdaqiamMQQRIDHLALLNEKQAASSQESReleelrgKNES 178
Cdd:TIGR00618  312 IHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQT--------LHSQEIHIRDAHEVATSIREISC-------QQHT 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   179 LTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAfndltEEHNKASQEWAE-KQTHLEKEL 257
Cdd:TIGR00618  377 LTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHA-----KKQQELQQRYAElCAAAITCTA 451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   258 STALQDKKYLEEKNEILQGKLSQLEERaSQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQ 337
Cdd:TIGR00618  452 QCEKLEKIHLQESAQSLKEREQQLQTK-EQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRM 530

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   338 EAQLLAERGHFEEEKQQLASLIADLQsSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAK 417
Cdd:TIGR00618  531 QRGEQTYAQLETSEEDVYHQLTSERK-QRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDM 609

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   418 KEQAQMVQSLQEQEQAA-QGLRQQVEQLSsslklKEQQLEEAAKDQEA---ARQDHAQQLAIVAEAREASLRERDAARQQ 493
Cdd:TIGR00618  610 LACEQHALLRKLQPEQDlQDVRLHLQQCS-----QELALKLTALHALQltlTQERVREHALSIRVLPKELLASRQLALQK 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   494 LETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHV-TELEAQLKAEQ 572
Cdd:TIGR00618  685 MQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQArTVLKARTEAHF 764

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   573 QKVAEREKVMQEKAQLQEqllaLEETLQITKGSLEEEKHRTADALAEQQrcvTKMEAESRSLMEQREQEQKALEQEKagr 652
Cdd:TIGR00618  765 NNNEEVTAALQTGAELSH----LAAEIQFFNRLREEDTHLLKTLEAEIG---QEIPSDEDILNLQCETLVQEEEQFL--- 834

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178   653 kglearlQQLEE--ARQAETEALRRELAEATASQHRAESESEQLIREVESW 701
Cdd:TIGR00618  835 -------SRLEEksATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKL 878
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1050-1576 1.80e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 80.34  E-value: 1.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1050 RAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHS-KAEEEWKAQVARGQQEAERKSSLISSLEEEVS 1128
Cdd:COG4913   290 LELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLA 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1129 ILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLReevEKQRVISEN---LR 1205
Cdd:COG4913   370 ALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLE---RRKSNIPARllaLR 446

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1206 QELTSQAERAE----------ELGQELKAWQEKFfqkEQALsalqlehtSTQALvSELLPAKHLcqqlqaeqaaaekrhr 1275
Cdd:COG4913   447 DALAEALGLDEaelpfvgeliEVRPEEERWRGAI---ERVL--------GGFAL-TLLVPPEHY---------------- 498

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1276 eeieqskqaagglrAELMRAQRELGELGPLR-QKVAEQERAAQQLRAEKASYAEQlsmlkkahgllaeenrglgeranlg 1354
Cdd:COG4913   499 --------------AAALRWVNRLHLRGRLVyERVRTGLPDPERPRLDPDSLAGK------------------------- 539

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1355 rqfLEVELDQAREkYVQELAAVRTDAE--THLAEMRQEAQSTTRelEVMTAKYEGAKVK----------VL-----EERQ 1417
Cdd:COG4913   540 ---LDFKPHPFRA-WLEAELGRRFDYVcvDSPEELRRHPRAITR--AGQVKGNGTRHEKddrrrirsryVLgfdnrAKLA 613

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1418 RFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGES---------QQEVQRLQAQLNELQT---QLSQKEQA 1485
Cdd:COG4913   614 ALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSwdeidvasaEREIAELEAELERLDAssdDLAALEEQ 693

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1486 AEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVR-SLEA 1564
Cdd:COG4913   694 LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELReNLEE 773

                         570
                  ....*....|..
gi 344240178 1565 QVAHADQQLRDL 1576
Cdd:COG4913   774 RIDALRARLNRA 785
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
136-642 1.89e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 80.08  E-value: 1.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  136 TEKDAQIAMMQQRIDHlALLNEKQAASSQESRELEEL----------RGKNESLTVRLHETLKQCQNLKTEKNQMDRKIS 205
Cdd:PRK02224  190 DQLKAQIEEKEEKDLH-ERLNGLESELAELDEEIERYeeqreqaretRDEADEVLEEHEERREELETLEAEIEDLRETIA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  206 QLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKAS----------QEWAEKQTHLEKELSTALQDKKYLEEKNEILQ 275
Cdd:PRK02224  269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDadaeavearrEELEDRDEELRDRLEECRVAAQAHNEEAESLR 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  276 GKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQL 355
Cdd:PRK02224  349 EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRERE 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  356 ASLIADLQSSISNLSQAKEELEQA--------------------SQAQGAQLTAQVASLTALNTTLQQQQDQeLASLKEQ 415
Cdd:PRK02224  429 AELEATLRTARERVEEAEALLEAGkcpecgqpvegsphvetieeDRERVEELEAELEDLEEEVEEVEERLER-AEDLVEA 507

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  416 AK-----KEQAQMVQSL--------QEQEQAAQGLRQQVEQLSSslklKEQQLEEAAKDQEAARQDHAQQLAivaeAREA 482
Cdd:PRK02224  508 EDrierlEERREDLEELiaerretiEEKRERAEELRERAAELEA----EAEEKREAAAEAEEEAEEAREEVA----ELNS 579

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  483 SLRERDAARQQLETLEkEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELH-----ACIEAAHQEQRQA 557
Cdd:PRK02224  580 KLAELKERIESLERIR-TLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEaefdeARIEEAREDKERA 658

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  558 QAHVTELEAQLkaeQQKVAEREKVMQEKAQLQEQLLALEEtLQITKGSLeEEKHRTADALAEQQRCVTKMEAESRSLMEQ 637
Cdd:PRK02224  659 EEYLEQVEEKL---DELREERDDLQAEIGAVENELEELEE-LRERREAL-ENRVEALEALYDEAEELESMYGDLRAELRQ 733


                  ....*
gi 344240178  638 REQEQ 642
Cdd:PRK02224  734 RNVET 738
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 454-1197 2.23e-14

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 79.88  E-value: 2.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   454 QLEEAAKDQEAAR--QDHAQQLAIVAEAREASLRERDAarQQLETLEKEKAA---KLESLQQQLEAANEARDSVQTSV-T 527
Cdd:pfam12128  213 PPKSRLNRQQVEHwiRDIQAIAGIMKIRPEFTKLQQEF--NTLESAELRLSHlhfGYKSDETLIASRQEERQETSAELnQ 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   528 QVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKA-QLQEQLLALEETLQITKGSL 606
Cdd:pfam12128  291 LLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLpSWQSELENLEERLKALTGKH 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   607 E--EEKHRTADALAEQQrCVTKMEAESRSLMEQREQEQKALEQEkagrkglEARLQQLEEARQAETEALRRELaeatasq 684
Cdd:pfam12128  371 QdvTAKYNRRRSKIKEQ-NNRDIAGIKDKLAKIREARDRQLAVA-------EDDLQALESELREQLEAGKLEF------- 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   685 hraeSESEQLIREVESWQKrfeaRQQEEARYSAMIQEQLAALKGDHEKAgQEAQEEAvevhgEGQIGEQQSPLAQLHTTL 764
Cdd:pfam12128  436 ----NEEEYRLKSRLGELK----LRLNQATATPELLLQLENFDERIERA-REEQEAA-----NAEVERLQSELRQARKRR 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   765 ARALQQVKEKEVRAQKLADDLTTLQEKMASTSkvAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESNWLEEQRGGP-- 842
Cdd:pfam12128  502 DQASEALRQASRRLEERQSALDELELQLFPQA--GTLLHFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGEln 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   843 FSSPQAALKAME-QEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTL 921
Cdd:pfam12128  580 LYGVKLDLKRIDvPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLF 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   922 NEQRVEFAALQEALdhalteKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQL-----VKKEKEQHPAGSTGGEEAS 996
Cdd:pfam12128  660 DEKQSEKDKKNKAL------AERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKreartEKQAYWQVVEGALDAQLAL 733

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   997 APEA-------------QLETVRKTE----APDP--------EVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRA 1051
Cdd:pfam12128  734 LKAAiaarrsgakaelkALETWYKRDlaslGVDPdviaklkrEIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLA 813

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1052 EQ----DKALETLQGQLEEKTQE-------LGHSQAASASAQRELTALHAKAqdhsKAEEEWKAQVARGQQEAErkssli 1120
Cdd:pfam12128  814 TQlsniERAISELQQQLARLIADtklrrakLEMERKASEKQQVRLSENLRGL----RCEMSKLATLKEDANSEQ------ 883

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  1121 ssLEEEVSILNRQVlekegesKELKRLVVAESEKSQKLEERLRllqvetassSARAAERSSALREEVQSLREEVEKQ 1197
Cdd:pfam12128  884 --AQGSIGERLAQL-------EDLKLKRDYLSESVKKYVEHFK---------NVIADHSGSGLAETWESLREEDHYQ 942
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
322-743 3.15e-14

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 79.04  E-value: 3.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  322 QLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQAsQAQGAQLTAQVASLTALNTtl 401
Cdd:COG4717    50 RLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEEL-EAELEELREELEKLEKLLQ-- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  402 QQQQDQELASLKEQAKKEQAQmVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEARE 481
Cdd:COG4717   127 LLPLYQELEALEAELAELPER-LEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQ 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  482 ASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARD-----------SVQTSVTQVQQEKAELSQKIEELHACIEAA 550
Cdd:COG4717   206 QRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlkearlllliaAALLALLGLGGSLLSLILTIAGVLFLVLGL 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  551 HQEQRQAQAHVTELEAQLKAEQQKVAEREKVmqEKAQLQEQLLALEETLQITKGSLEEEKHRTADAlaeQQRCVTKMEAE 630
Cdd:COG4717   286 LALLFLLLAREKASLGKEAEELQALPALEEL--EEEELEELLAALGLPPDLSPEELLELLDRIEEL---QELLREAEELE 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  631 SRSLMEQREQEQKALEQEK--AGRKGLEARLQQLEEARQAETE--ALRRELAE---------ATASQHRAESESEQLIRE 697
Cdd:COG4717   361 EELQLEELEQEIAALLAEAgvEDEEELRAALEQAEEYQELKEEleELEEQLEEllgeleellEALDEEELEEELEELEEE 440

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 344240178  698 VESWQKRFEARQQEEARysamIQEQLAALKGDHEKAGQEAQEEAVE 743
Cdd:COG4717   441 LEELEEELEELREELAE----LEAELEQLEEDGELAELLQELEELK 482
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1120-1586 4.72e-14

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 78.80  E-value: 4.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1120 ISSLEEEVSILNR--QVLEKEGESKELKRLVVAESEKSQKLEERLRLLQ-VETASSSARAAERSSALREEVQSLREEVEK 1196
Cdd:COG4913   227 ADALVEHFDDLERahEALEDAREQIELLEPIRELAERYAAARERLAELEyLRAALRLWFAQRRLELLEAELEELRAELAR 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1197 QRVISENLRQELTSQAERAEEL--------GQELKAWQEKFFQKEQALSALQLEHTSTQALVSELlpakhlcQQLQAEQA 1268
Cdd:COG4913   307 LEAELERLEARLDALREELDELeaqirgngGDRLEQLEREIERLERELEERERRRARLEALLAAL-------GLPLPASA 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1269 AAEKRHREEIEQSKQAAGGLRAELMRAQRELgelgplRQKVAEQERAAQQLRAEKAS-----------YAEQLSMLKKAH 1337
Cdd:COG4913   380 EEFAALRAEAAALLEALEEELEALEEALAEA------EAALRDLRRELRELEAEIASlerrksniparLLALRDALAEAL 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1338 GLLAEENRGLGEranlgrqFLEVELDQAR--------------------EKYVQELAAV-RTDAETHL------------ 1384
Cdd:COG4913   454 GLDEAELPFVGE-------LIEVRPEEERwrgaiervlggfaltllvppEHYAAALRWVnRLHLRGRLvyervrtglpdp 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1385 AEMRQEAQSTTRELEVMTAKYEGAKVKVLEER---------QRFQEERQKLTA--QVEElSKKLTEYDQASKVQQQ---- 1449
Cdd:COG4913   527 ERPRLDPDSLAGKLDFKPHPFRAWLEAELGRRfdyvcvdspEELRRHPRAITRagQVKG-NGTRHEKDDRRRIRSRyvlg 605

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1450 -----KLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ--ELQDQLRDLEQLQK 1522
Cdd:COG4913   606 fdnraKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREiaELEAELERLDASSD 685

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178 1523 ENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1586
Cdd:COG4913   686 DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRA 749
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
889-1474 5.80e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 78.54  E-value: 5.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  889 VARLTRERSQAQADLAQEKAAKAELEvrLQNTLNEQRVEFAALQEALDHALTEKEgkdqeLAKLRGQEAAQR-TELKELQ 967
Cdd:PRK02224  178 VERVLSDQRGSLDQLKAQIEEKEEKD--LHERLNGLESELAELDEEIERYEEQRE-----QARETRDEADEVlEEHEERR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  968 QTLEHLKTQLVKKEkeqhpagstggeeasapEAQLETVRKTEAPDPEVEALRAEVSKLEQQCqqqkqqvEGLTHSLESER 1047
Cdd:PRK02224  251 EELETLEAEIEDLR-----------------ETIAETEREREELAEEVRDLRERLEELEEER-------DDLLAEAGLDD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1048 ASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEV 1127
Cdd:PRK02224  307 ADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEI 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1128 SILNRQVLEKEgeskelKRLVVAESEKsQKLEERLRLLQVETASSSARAAERSSALR------EEVQSLREEVE----KQ 1197
Cdd:PRK02224  387 EELEEEIEELR------ERFGDAPVDL-GNAEDFLEELREERDELREREAELEATLRtarervEEAEALLEAGKcpecGQ 459

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1198 RVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQlEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1277
Cdd:PRK02224  460 PVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAE-DLVEAEDRIERLEERREDLEELIAERRETIEEKRER 538

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1278 IEQSKQAAGGLRAEL-----------MRAQRELGELGPLRQKVAEQERAAQQLR------AEKASYAEQLSMLKKAHGLL 1340
Cdd:PRK02224  539 AEELRERAAELEAEAeekreaaaeaeEEAEEAREEVAELNSKLAELKERIESLErirtllAAIADAEDEIERLREKREAL 618

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1341 AEENR----GLGERANLGRQfLEVELDQARekyVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKvLEER 1416
Cdd:PRK02224  619 AELNDerreRLAEKRERKRE-LEAEFDEAR---IEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENE-LEEL 693

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1417 QRFQEERQKLTAQVEELSkklTEYDQASKVQQQ--KLKAfqaqgGESQQEVQRLQAQLNE 1474
Cdd:PRK02224  694 EELRERREALENRVEALE---ALYDEAEELESMygDLRA-----ELRQRNVETLERMLNE 745
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 220-595 6.24e-14

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 78.46  E-value: 6.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  220 EFASHLQQLQGAFNDLTEEHNKASQewaekqtHLEKeLSTALQdkkyLEEKNEILQGKLSQLEERASQQCESPAQEKGEV 299
Cdd:COG3096   310 EMARELEELSARESDLEQDYQAASD-------HLNL-VQTALR----QQEKIERYQEDLEELTERLEEQEEVVEEAAEQL 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  300 LGDALQLETLKQEAAKLAahnTQLQARIETLDCERS-----QQEAQLLaerghfeEEKQQLASLiADLqsSISNLsqakE 374
Cdd:COG3096   378 AEAEARLEAAEEEVDSLK---SQLADYQQALDVQQTraiqyQQAVQAL-------EKARALCGL-PDL--TPENA----E 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  375 ELEQASQAQGAQLTAQVASLtalnttlqqqqDQELaSLKEQAKKEQAQMVQSLQ------EQEQAAQGLRQQVEQLSSSL 448
Cdd:COG3096   441 DYLAAFRAKEQQATEEVLEL-----------EQKL-SVADAARRQFEKAYELVCkiagevERSQAWQTARELLRRYRSQQ 508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  449 KLKEQ------QLEEAakDQEAARQDHAQQLAivAEAREASLRERDAArQQLETLEKEKAAKLESLQQQLEAANEARDSV 522
Cdd:COG3096   509 ALAQRlqqlraQLAEL--EQRLRQQQNAERLL--EEFCQRIGQQLDAA-EELEELLAELEAQLEELEEQAAEAVEQRSEL 583

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEA-------QLKAEQQKVAEREKVMQEKAQLQEQLLAL 595
Cdd:COG3096   584 RQQLEQLRARIKELAARAPAWLAAQDALERLREQSGEALADSQEvtaamqqLLEREREATVERDELAARKQALESQIERL 663
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 482-707 9.44e-14

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 75.96  E-value: 9.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  482 ASLRERDAARQQLETLEKEkaakLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHV 561
Cdd:COG4942    17 AQADAAAEAEAELEQLQQE----IAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  562 TELEAQLKAEQQKVAEREKVMQEKAQL--------QEQLLALEETLQITKGSLEEEKHR------TADALAEQQRCVTKM 627
Cdd:COG4942    93 AELRAELEAQKEELAELLRALYRLGRQpplalllsPEDFLDAVRRLQYLKYLAPARREQaeelraDLAELAALRAELEAE 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  628 EAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRElaeatasQHRAESESEQLIREVESWQKRFEA 707
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQE-------AEELEALIARLEAEAAAAAERTPA 245
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 240-1163 2.00e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 76.93  E-value: 2.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   240 NKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQgKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAH 319
Cdd:pfam02463  145 EIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIE-ETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEE 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   320 NTQLQARIETLDCERSQQEAQLLAERghfeEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNT 399
Cdd:pfam02463  224 EYLLYLDYLKLNEERIDLLQELLRDE----QEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELK 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   400 TLQQQQDQELASLKEQAKKEQAQmVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQL-AIVAE 478
Cdd:pfam02463  300 SELLKLERRKVDDEEKLKESEKE-KKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEeELLAK 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   479 AREASLRERDAARQQLETLEK----EKAAKLES-LQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELhacieaahqe 553
Cdd:pfam02463  379 KKLESERLSSAAKLKEEELELkseeEKEAQLLLeLARQLEDLLKEEKKEELEILEEEEESIELKQGKLTE---------- 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   554 qrqaQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRS 633
Cdd:pfam02463  449 ----EKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   634 LMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEA--------TASQHRAESESEQLIREVESWQKRF 705
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTelplgarkLRLLIPKLKLPLKSIAVLEIDPILN 604

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   706 EARQQEEARysaMIQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDL 785
Cdd:pfam02463  605 LAQLDKATL---EADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQEL 681

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   786 TTLQEKMASTSKVAACLKTLVLKAG-EQQEMTSLELLKEPPGAGNKESNWLEEQRggpfsspqaALKAMEQEAEQMGSEL 864
Cdd:pfam02463  682 QEKAESELAKEEILRRQLEIKKKEQrEKEELKKLKLEAEELLADRVQEAQDKINE---------ELKLLKQKIDEEEEEE 752

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   865 ERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADlaQEKAAKAELEVRLQNTLNEQRVEFAALQealdhaltekeg 944
Cdd:pfam02463  753 EKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE--EKEEKLKAQEEELRALEEELKEEAELLE------------ 818

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   945 kdQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSK 1024
Cdd:pfam02463  819 --EEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEK 896

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1025 LEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTqelghsqaasasaqrELTALHAKAQDHSKAEEEWKA 1104
Cdd:pfam02463  897 EEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEEL---------------LLEEADEKEKEENNKEEEEER 961

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  1105 QVARGQQEAERKSSLISSLEEEVsilnRQVLEKEGESKELKRLVVAESEKSQKLEERLR 1163
Cdd:pfam02463  962 NKRLLLAKEELGKVNLMAIEEFE----EKEERYNKDELEKERLEEEKKKLIRAIIEETC 1016
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 397-722 2.46e-13

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 76.32  E-value: 2.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   397 LNTTLQQQQDQELASLKEQAKKEQAQmvqslqEQEQaaqgLRQQVEQLSSSLKlKEQQLEEAakdqEAARQ-DHAQQLAI 475
Cdd:pfam17380  271 LNQLLHIVQHQKAVSERQQQEKFEKM------EQER----LRQEKEEKAREVE-RRRKLEEA----EKARQaEMDRQAAI 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   476 VAE-AREASLRERDAARQQLE--------------TLEKEKAAKLESLQQQLEAANE-ARDSVQTSVTQVQQEKaELSQK 539
Cdd:pfam17380  336 YAEqERMAMERERELERIRQEerkrelerirqeeiAMEISRMRELERLQMERQQKNErVRQELEAARKVKILEE-ERQRK 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   540 IEELHACIEAAHQEQRQAQahvtELEAQlKAEQQKVAEREKVMQEKAQLQEQLLALEETlqitkgslEEEKHRTADALAE 619
Cdd:pfam17380  415 IQQQKVEMEQIRAEQEEAR----QREVR-RLEEERAREMERVRLEEQERQQQVERLRQQ--------EEERKRKKLELEK 481

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   620 QQRCVTKMEAESRSLMEQREQEQK-ALEQEKAGRKGLEarlQQLEEARQAETEALRRELAEatasqhrAESESEQLIREV 698
Cdd:pfam17380  482 EKRDRKRAEEQRRKILEKELEERKqAMIEEERKRKLLE---KEMEERQKAIYEEERRREAE-------EERRKQQEMEER 551

                          330       340
                   ....*....|....*....|....
gi 344240178   699 ESWQKRFEARQQEEARYSAMIQEQ 722
Cdd:pfam17380  552 RRIQEQMRKATEERSRLEAMERER 575
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 111-934 2.87e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 76.16  E-value: 2.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   111 KKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAASSQESRELEELRGKNESLTVRLHETLKQC 190
Cdd:pfam02463  180 EETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   191 QNLKTEKNQ-------MDRKISQLSEENGDLSFKVREF-ASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQ 262
Cdd:pfam02463  260 IEKEEEKLAqvlkenkEEEKEKKLQEEELKLLAKEEEElKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEE 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   263 DKKYLEEKNeilqgKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIEtldcERSQQEAQLL 342
Cdd:pfam02463  340 LEKELKELE-----IKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELK----SEEEKEAQLL 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   343 AERghfeeeKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNtTLQQQQDQELASLKEQAKKEQAQ 422
Cdd:pfam02463  411 LEL------ARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKL-LKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   423 MVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEARE-----ASLRERDAARQQLETL 497
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKvaistAVIVEVSATADEVEER 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   498 EKEKAAKLESLQ--------QQLEAANEARDSVQTSVTQVQQEKAELS-------QKIEELHACIEAAHQEQRQAQAHVT 562
Cdd:pfam02463  564 QKLVRALTELPLgarklrllIPKLKLPLKSIAVLEIDPILNLAQLDKAtleadedDKRAKVVEGILKDTELTKLKESAKA 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   563 ELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQ 642
Cdd:pfam02463  644 KESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   643 KALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQ 722
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   723 LAALKGDHEKAGQEAQEEAVEVHGEgqigeqqsplaQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMastSKVAACL 802
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEE-----------KIKEEELEELALELKEEQKLEKLAEEELERLEEE---ITKEELL 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   803 KTLVLKAGEQQEMTSLELLKEPPGAGNKESNWLEEQRggpfSSPQAALKAMEQEAEQMGSELERLRVAL-MKSQGQQQEE 881
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEES----QKLNLLEEKENEIEERIKEEAEILLKYEeEPEELLLEEA 945

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 344240178   882 RGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEA 934
Cdd:pfam02463  946 DEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKE 998
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 145-677 4.57e-13

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 75.65  E-value: 4.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   145 MQQRIDHLALLNEKQAASSQESRELEELRGKNESLTvRLHETLKQC--QNLKTEKNQMDRKISQLSEEngdlsfKVREFA 222
Cdd:pfam12128  339 IETAAADQEQLPSWQSELENLEERLKALTGKHQDVT-AKYNRRRSKikEQNNRDIAGIKDKLAKIREA------RDRQLA 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   223 SHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELSTA---LQDKKYLEEKNEILQGKLSQLEeRASQQCESPAQEKGEV 299
Cdd:pfam12128  412 VAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELklrLNQATATPELLLQLENFDERIE-RAREEQEAANAEVERL 490

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   300 LGDALQLETLKQEAAKlaaHNTQLQARIETLDCERSQQEAQLLAERG---HFEEE-----KQQLASLIA-------DLQS 364
Cdd:pfam12128  491 QSELRQARKRRDQASE---ALRQASRRLEERQSALDELELQLFPQAGtllHFLRKeapdwEQSIGKVISpellhrtDLDP 567

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   365 SISNLSQAKE--------ELEQASQAQGAQLTAQV-ASLTALNTTLQ------QQQDQELASLKEQAKKEQAQMVQSLQE 429
Cdd:pfam12128  568 EVWDGSVGGElnlygvklDLKRIDVPEWAASEEELrERLDKAEEALQsarekqAAAEEQLVQANGELEKASREETFARTA 647

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   430 QEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQL--------AIVAEAREASLRERDAARQQLETLEKEK 501
Cdd:pfam12128  648 LKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLkqldkkhqAWLEEQKEQKREARTEKQAYWQVVEGAL 727

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   502 AAKLESLQQQLEAANEARDSVQTSVTQ----------VQQEK-AELSQKIEELHACIE-AAHQEQRQAQAHVTELEAQLK 569
Cdd:pfam12128  728 DAQLALLKAAIAARRSGAKAELKALETwykrdlaslgVDPDViAKLKREIRTLERKIErIAVRRQEVLRYFDWYQETWLQ 807

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   570 AEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEK 649
Cdd:pfam12128  808 RRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGS 887

                          570       580
                   ....*....|....*....|....*...
gi 344240178   650 AGRKglEARLQQLEEARQAETEALRREL 677
Cdd:pfam12128  888 IGER--LAQLEDLKLKRDYLSESVKKYV 913
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 889-1730 5.73e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 75.15  E-value: 5.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   889 VARLTRERSQAQADLAQEkaakaelevrLQNTLNEQRVEFAALQEALDHALTEKEgkdqelaKLRGQEAAQRTELKELQQ 968
Cdd:pfam15921  129 MADIRRRESQSQEDLRNQ----------LQNTVHELEAAKCLKEDMLEDSNTQIE-------QLRKMMLSHEGVLQEIRS 191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   969 TLEHLKTQLVKKEKEQHpagstggeeasapeaQLETVrkteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESE-R 1047
Cdd:pfam15921  192 ILVDFEEASGKKIYEHD---------------SMSTM--------HFRSLGSAISKILRELDTEISYLKGRIFPVEDQlE 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1048 ASRAEQDKALETLQGQLEEKTQELghsqaaSASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSL----ISSL 1123
Cdd:pfam15921  249 ALKSESQNKIELLLQQHQDRIEQL------ISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMymrqLSDL 322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1124 EEEVSILNRQVLEK----EGESKEL-KRLVVAESEKSQKLEERLRLLQvETASSSARAAERSSAL--REEVQSLREEVEK 1196
Cdd:pfam15921  323 ESTVSQLRSELREAkrmyEDKIEELeKQLVLANSELTEARTERDQFSQ-ESGNLDDQLQKLLADLhkREKELSLEKEQNK 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1197 Q--------RVISENLRQELTSQAERAEELGQELKAWQ-EKFFQKEQALSALQLEHTSTQAlVSELLPAKHLCQQLQAEQ 1267
Cdd:pfam15921  402 RlwdrdtgnSITIDHLRRELDDRNMEVQRLEALLKAMKsECQGQMERQMAAIQGKNESLEK-VSSLTAQLESTKEMLRKV 480

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1268 AAAEKRHREEIEQSKQAAGGLRAELMRAQREL----GELGPLRQKVAEQERAAQQLRAEkasyAEQLSMLKKAHGLLAEE 1343
Cdd:pfam15921  481 VEELTAKKMTLESSERTVSDLTASLQEKERAIeatnAEITKLRSRVDLKLQELQHLKNE----GDHLRNVQTECEALKLQ 556

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1344 NRGLGERANLGRQFLE--VELDQAREKYVQELAAVRTDAETHLAEMRQEAQ----------STTRELEVMTAKYEGAKVK 1411
Cdd:pfam15921  557 MAEKDKVIEILRQQIEnmTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQefkilkdkkdAKIRELEARVSDLELEKVK 636

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1412 VL---EERQR----FQEERQKLTAQVEELSKKLTEYDQASKVQQQKlkaFQAQGGESQQEVQRLQAQLNELQTQLSQKEQ 1484
Cdd:pfam15921  637 LVnagSERLRavkdIKQERDQLLNEVKTSRNELNSLSEDYEVLKRN---FRNKSEEMETTTNKLKMQLKSAQSELEQTRN 713

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1485 A----------AEHYKLQMEKAKThydAKKQQNQELQDQLRDLEQ-LQKENKE---LRAEAERLGRELQQAGLKTKEAEQ 1550
Cdd:pfam15921  714 TlksmegsdghAMKVAMGMQKQIT---AKRGQIDALQSKIQFLEEaMTNANKEkhfLKEEKNKLSQELSTVATEKNKMAG 790

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1551 ACRHLSAQVRSLEAQVAHADQQLrDLGKFQVA--TDALKSREPQKPQLDLSiDSLDLSLEEG--------------TPCS 1614
Cdd:pfam15921  791 ELEVLRSQERRLKEKVANMEVAL-DKASLQFAecQDIIQRQEQESVRLKLQ-HTLDVKELQGpgytsnssmkprllQPAS 868

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1615 VTRS-GDMSASLPCACLLSvccsslwfwYDDRRLLRAQEN-TQSAPASQASLRATSSTQSLARLG-SPDDGNSALLSLPG 1691
Cdd:pfam15921  869 FTRThSNVPSSQSTASFLS---------HHSRKTNALKEDpTRDLKQLLQELRSVINEEPTVQLSkAEDKGRAPSLGALD 939

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|..
gi 344240178  1692 YRPT---TRSSARRSQARMSSGAPQGRNSFYMGTCQDEPEQL 1730
Cdd:pfam15921  940 DRVRdciIESSLRSDICHSSSNSLQTEGSKSSETCSREPVLL 981
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
351-1020 7.04e-13

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 74.95  E-value: 7.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  351 EKQQLASLIADLQSSISNLSQAKEELEQASQaqgaqltaQVASLTALnttlqQQQDQELASLKEQakkeqaqmvqsLQEQ 430
Cdd:COG4913   219 EEPDTFEAADALVEHFDDLERAHEALEDARE--------QIELLEPI-----RELAERYAAARER-----------LAEL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  431 EQAAQGLRQQVEQLSSSLklkeqqLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLekeKAAKLESLQQ 510
Cdd:COG4913   275 EYLRAALRLWFAQRRLEL------LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGN---GGDRLEQLER 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  511 QLEAANEARDsvqtsvtQVQQEKAELSQKIEELHACIEAAHQE----QRQAQAHVTELEAQLKAEQQKVAEREkvmQEKA 586
Cdd:COG4913   346 EIERLERELE-------ERERRRARLEALLAALGLPLPASAEEfaalRAEAAALLEALEEELEALEEALAEAE---AALR 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  587 QLQEQLLALEETLQI---TKGSLEEEKHRTADALAEQqrcVTKMEAESR---SLMEQREQE---QKALEQEKAGRKgleA 657
Cdd:COG4913   416 DLRRELRELEAEIASlerRKSNIPARLLALRDALAEA---LGLDEAELPfvgELIEVRPEEerwRGAIERVLGGFA---L 489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  658 RL----QQLEEARQA-ETEALRREL-----AEATASQHRAESESEQLIREVESWQKRFEA--RQQEEARYSAMIQEQLAA 725
Cdd:COG4913   490 TLlvppEHYAAALRWvNRLHLRGRLvyervRTGLPDPERPRLDPDSLAGKLDFKPHPFRAwlEAELGRRFDYVCVDSPEE 569

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  726 LKgDHEKA----GQEAQEEAVEVHG-EGQIGEQ-------QSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMA 793
Cdd:COG4913   570 LR-RHPRAitraGQVKGNGTRHEKDdRRRIRSRyvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERRE 648

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  794 STSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKEsnwleeqrggpfsspqaaLKAMEQEAEQMGSELERLRvalmk 873
Cdd:COG4913   649 ALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDD------------------LAALEEQLEELEAELEELE----- 705

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  874 sqgqqqeergqqeREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVE-FAALQEALDHALTEKEGKDQElAKL 952
Cdd:COG4913   706 -------------EELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLElRALLEERFAAALGDAVERELR-ENL 771

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  953 RGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPDPEVEALRA 1020
Cdd:COG4913   772 EERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLEEDGLPEYEERFKEL 839
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 894-1578 8.20e-13

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 74.99  E-value: 8.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  894 RERSQAQADLAQE--KAAKAELeVRLQNTLNEQRVEFAALQEALdHALTEK-----------EGKDQELAKLRGQEAAQR 960
Cdd:COG3096   377 LAEAEARLEAAEEevDSLKSQL-ADYQQALDVQQTRAIQYQQAV-QALEKAralcglpdltpENAEDYLAAFRAKEQQAT 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  961 TELKELQQTLehlktQLVKKEKEQHP---------AGSTGGEEA-SAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQ 1030
Cdd:COG3096   455 EEVLELEQKL-----SVADAARRQFEkayelvckiAGEVERSQAwQTARELLRRYRSQQALAQRLQQLRAQLAELEQRLR 529

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1031 QQKQQV---EGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEW-KAQV 1106
Cdd:COG3096   530 QQQNAErllEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWlAAQD 609

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1107 ARGQQEAERKSSLISSleEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERL---------RLLQV---------- 1167
Cdd:COG3096   610 ALERLREQSGEALADS--QEVTAAMQQLLEREREATVERDELAARKQALESQIERLsqpggaedpRLLALaerlggvlls 687

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1168 ---------ETASSSARAAERSSAL--------REEVQSL-----------------------REEVEKQRVISENLRQE 1207
Cdd:COG3096   688 eiyddvtleDAPYFSALYGPARHAIvvpdlsavKEQLAGLedcpedlyliegdpdsfddsvfdAEELEDAVVVKLSDRQW 767

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1208 LTS------------QAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVsellpAKHLcqqlqaeqaaaekrhr 1275
Cdd:COG3096   768 RYSrfpevplfgraaREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQFV-----GGHL---------------- 826

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1276 eeieqSKQAAGGLRAELMRAQRELGElgpLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHG---LLAEEnrGLGERan 1352
Cdd:COG3096   827 -----AVAFAPDPEAELAALRQRRSE---LERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPqanLLADE--TLADR-- 894

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1353 lgRQFLEVELDQARE--KYVQELAAVRTDAETHLAEMRQEAQSttrelevmtakYEGAKVKVLEERQRFQEERQKLTAqV 1430
Cdd:COG3096   895 --LEELREELDAAQEaqAFIQQHGKALAQLEPLVAVLQSDPEQ-----------FEQLQADYLQAKEQQRRLKQQIFA-L 960

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1431 EELSKKLTE--YDQAskvqqqklkafQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKA-------KTHYD 1501
Cdd:COG3096   961 SEVVQRRPHfsYEDA-----------VGLLGENSDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYnqvlaslKSSRD 1029

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178 1502 AKKQQNQELQDQLRDLEQLQKENKELRAEAERlgRELQQAGLKTKeaeQACRHLSAQVRSLEAQVAHADQQLRDLGK 1578
Cdd:COG3096  1030 AKQQTLQELEQELEELGVQADAEAEERARIRR--DELHEELSQNR---SRRSQLEKQLTRCEAEMDSLQKRLRKAER 1101
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 108-609 9.32e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 74.29  E-value: 9.32e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   108 RRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQaasSQESRELEELRGKNESLTVRLHETL 187
Cdd:TIGR04523  162 NDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKN---KSLESQISELKKQNNQLKDNIEKKQ 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   188 KQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWA----EKQTHLEKELSTALQD 263
Cdd:TIGR04523  239 QEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISdlnnQKEQDWNKELKSELKN 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   264 KkylEEKNEILQGKLSQLEERASQ-------------QCESPAQEKGEVLGDAL-QLETLKQEAAKLAAHNTQLQARIET 329
Cdd:TIGR04523  319 Q---EKKLEEIQNQISQNNKIISQlneqisqlkkeltNSESENSEKQRELEEKQnEIEKLKKENQSYKQEIKNLESQIND 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   330 LDCERSQQE--AQLLAERGH-FEEEKQQLASLIADLQSSISNLSQAKEELEQasqaqgaQLTAQVASLTALNTTLQQQQd 406
Cdd:TIGR04523  396 LESKIQNQEklNQQKDEQIKkLQQEKELLEKEIERLKETIIKNNSEIKDLTN-------QDSVKELIIKNLDNTRESLE- 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   407 QELASLKEQAKKEQaqmvqslQEQEQAAQGLRQQVEQLsSSLKLKEQQLEEAAKDqeaarqdhaqqlaivAEAREASLRE 486
Cdd:TIGR04523  468 TQLKVLSRSINKIK-------QNLEQKQKELKSKEKEL-KKLNEEKKELEEKVKD---------------LTKKISSLKE 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   487 RDaarQQLETLEKEKAAKLESLQQQLEAANEARDSvqtsvTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEA 566
Cdd:TIGR04523  525 KI---EKLESEKKEKESKISDLEDELNKDDFELKK-----ENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEK 596

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 344240178   567 QLKAEQQKVAERE-KVMQEKAQLQ------EQLLALEETLQITKGSLEEE 609
Cdd:TIGR04523  597 EKKDLIKEIEEKEkKISSLEKELEkakkenEKLSSIIKNIKSKKNKLKQE 646
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
478-1066 1.12e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 74.31  E-value: 1.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  478 EAREASLRERDAARQQLETLEKEKAAKLE-SLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAaHQEQRQ 556
Cdd:PRK02224  173 DARLGVERVLSDQRGSLDQLKAQIEEKEEkDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEE-HEERRE 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  557 AqahVTELEAQLKAEQQKVA----EREKVMQEKAQLQEQLLALEETLQITKGSLEEEKhRTADALAEQQRCVTKMEAESR 632
Cdd:PRK02224  252 E---LETLEAEIEDLRETIAeterEREELAEEVRDLRERLEELEEERDDLLAEAGLDD-ADAEAVEARREELEDRDEELR 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  633 -SLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQaETEALRRELAEATASQHRAESESEQLIREVESWQKRFE---AR 708
Cdd:PRK02224  328 dRLEECRVAAQAHNEEAESLREDADDLEERAEELRE-EAAELESELEEAREAVEDRREEIEELEEEIEELRERFGdapVD 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  709 QQEEARYSAMIQEQLAALKGDHE------KAGQEAQEEAVEVHGEGQIGEQQSPLAQlhttlARALQQVKEKEVRAQKLA 782
Cdd:PRK02224  407 LGNAEDFLEELREERDELREREAeleatlRTARERVEEAEALLEAGKCPECGQPVEG-----SPHVETIEEDRERVEELE 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  783 DDLTTLQEKMASTSKVAACLKTLVLKAGEqqemtsLELLKEPPGAGNKEsnwLEEQRggpfsspqAALKAMEQEAEQMGS 862
Cdd:PRK02224  482 AELEDLEEEVEEVEERLERAEDLVEAEDR------IERLEERREDLEEL---IAERR--------ETIEEKRERAEELRE 544

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  863 ELERLRvalmksqgqqqeergqqerevarltrERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDH---AL 939
Cdd:PRK02224  545 RAAELE--------------------------AEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERirtLL 598

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  940 TEKEGKDQELAKLRgqeaAQRTELKELQ-QTLEHLKTqlvKKEKEQHPAGSTGG---EEASAPEAQLETVrkTEAPDPEV 1015
Cdd:PRK02224  599 AAIADAEDEIERLR----EKREALAELNdERRERLAE---KRERKRELEAEFDEariEEAREDKERAEEY--LEQVEEKL 669

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 344240178 1016 EALRAEVSKLEQQCQQQKQQVEGLtHSLESERASRAEQDKALETLQGQLEE 1066
Cdd:PRK02224  670 DELREERDDLQAEIGAVENELEEL-EELRERREALENRVEALEALYDEAEE 719
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
943-1533 1.17e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.33  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  943 EGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQhpagstggeeasapEAQLETVRKTEapdPEVEALRAEV 1022
Cdd:PRK03918  161 ENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKEL--------------EEVLREINEIS---SELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1023 SKLEQQCQQQKQQVEGLThSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEE-- 1100
Cdd:PRK03918  224 EKLEKEVKELEELKEEIE-ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEfy 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1101 -EWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLV--VAESEKSQKLEERLRLLQVETASSSARAA 1177
Cdd:PRK03918  303 eEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEkrLEELEERHELYEEAKAKKEELERLKKRLT 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1178 ----ERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQ--------------------------- 1226
Cdd:PRK03918  383 gltpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKgkcpvcgrelteehrkelleeytaelk 462

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1227 ------EKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQS-------KQAAGGLRAELM 1293
Cdd:PRK03918  463 riekelKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKaeeyeklKEKLIKLKGEIK 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1294 RAQRELGELGPLRQKVAEQERAAQQLRAEKASYAEQLSmlKKAHGLLAEENRGLGERANLGRQFLEVEldqarekyvqel 1373
Cdd:PRK03918  543 SLKKELEKLEELKKKLAELEKKLDELEEELAELLKELE--ELGFESVEELEERLKELEPFYNEYLELK------------ 608

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1374 aavrtDAETHLAEMRQEAQSTTRELEvmtakyegakvKVLEERQRFQEERQKLTAQVEELSKKLTEyDQASKVQQQKLka 1453
Cdd:PRK03918  609 -----DAEKELEREEKELKKLEEELD-----------KAFEELAETEKRLEELRKELEELEKKYSE-EEYEELREEYL-- 669

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1454 fqaqggESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKThydaKKQQNQELQDQLRDLEQLQKENKELRAEAER 1533
Cdd:PRK03918  670 ------ELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK----AKKELEKLEKALERVEELREKVKKYKALLKE 739
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
305-578 1.29e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 74.18  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  305 QLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGhfeeekqqlaslIADLQSSISNLSQAKEELeqasqaqg 384
Cdd:COG4913   611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQR------------LAEYSWDEIDVASAEREI-------- 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  385 AQLTAQVASLTALNTTLQQQQDQElaslkEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEA 464
Cdd:COG4913   671 AELEAELERLDASSDDLAALEEQL-----EELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARL 745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  465 ARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANE----ARDSVQTSVTQVQQEKAELSQ-- 538
Cdd:COG4913   746 ELRALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNRewpaETADLDADLESLPEYLALLDRle 825

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 344240178  539 --KIEELHAciEAAHQEQRQAQAHVTELEAQLKAEQQKVAER 578
Cdd:COG4913   826 edGLPEYEE--RFKELLNENSIEFVADLLSKLRRAIREIKER 865
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
418-805 1.58e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 73.26  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  418 KEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAakDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETL 497
Cdd:COG4717    74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL--REELEKLEKLLQLLPLYQELEALEAELAELPERLEEL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  498 EkEKAAKLESLQQQLEAANEARDSVQTSVTQ-VQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVA 576
Cdd:COG4717   152 E-ERLEELRELEEELEELEAELAELQEELEElLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  577 EREKVMqEKAQLQEQLLALEETLQIT----------------------------------KGSLEEEKHRTADALAEQQR 622
Cdd:COG4717   231 QLENEL-EAAALEERLKEARLLLLIAaallallglggsllsliltiagvlflvlgllallFLLLAREKASLGKEAEELQA 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  623 CVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQaETEALRRELAEATASQHRAE------SESEQlir 696
Cdd:COG4717   310 LPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLR-EAEELEEELQLEELEQEIAAllaeagVEDEE--- 385

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  697 EVESWQKRFEARQQEEARYSAmIQEQLAALKGDHEKAGQEAQEEAVEV---HGEGQIGEQQSPLAQLHTTLARALQQVK- 772
Cdd:COG4717   386 ELRAALEQAEEYQELKEELEE-LEEQLEELLGELEELLEALDEEELEEeleELEEELEELEEELEELREELAELEAELEq 464

                         410       420       430
                  ....*....|....*....|....*....|....
gi 344240178  773 -EKEVRAQKLADDLTTLQEKMASTSKVAACLKTL 805
Cdd:COG4717   465 lEEDGELAELLQELEELKAELRELAEEWAALKLA 498
growth_prot_Scy NF041483
polarized growth protein Scy;
317-1533 2.24e-12

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 73.32  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  317 AAHNTQLQARIETLDCERSQQEAQLLAERghfeeeKQQLASLIADlqssisNLSQAkEELEQASQAQGAQLTAQVASlta 396
Cdd:NF041483  111 AEHQARLQAELHTEAVQRRQQLDQELAER------RQTVESHVNE------NVAWA-EQLRARTESQARRLLDESRA--- 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  397 lnttlqqQQDQELASLKEQAKKEQAQMVQSLQEQEQAAqglRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLaiv 476
Cdd:NF041483  175 -------EAEQALAAARAEAERLAEEARQRLGSEAESA---RAEAEAILRRARKDAERLLNAASTQAQEATDHAEQL--- 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  477 aeaREASLRERDAARQQLETLEKekaAKLESLQQQLEAANEARDSVQTSVTQVQQEKAelsqkiEELHACIEAAHQEQRQ 556
Cdd:NF041483  242 ---RSSTAAESDQARRQAAELSR---AAEQRMQEAEEALREARAEAEKVVAEAKEAAA------KQLASAESANEQRTRT 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  557 AQAHVTEL--EAQLKAEQQKvAEREKVMQEKAQLQEQLLAlEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSL 634
Cdd:NF041483  310 AKEEIARLvgEATKEAEALK-AEAEQALADARAEAEKLVA-EAAEKARTVAAEDTAAQLAKAARTAEEVLTKASEDAKAT 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  635 MEQREQEQKALEQE---KAGRKGLEARLQ--QLEEARQAETEALRRELAEATASQHRAESESEQLIREV--ESWQKRFEA 707
Cdd:NF041483  388 TRAAAEEAERIRREaeaEADRLRGEAADQaeQLKGAAKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAvaEGERIRGEA 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  708 R-----QQEEARYSAmiQEQLAALKGDHEKAGQEAQEEAVEVHGEGqIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLA 782
Cdd:NF041483  468 RreavqQIEEAARTA--EELLTKAKADADELRSTATAESERVRTEA-IERATTLRRQAEETLERTRAEAERLRAEAEEQA 544

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  783 DDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESnwLEEQRGgpfSSPQAALKAMEQEAEQMGS 862
Cdd:NF041483  545 EEVRAAAERAARELREETERAIAARQAEAAEELTRLHTEAEERLTAAEEA--LADARA---EAERIRREAAEETERLRTE 619

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  863 ELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAE-LEVRLQNTLNEQRVEFAALQEALDHALTE 941
Cdd:NF041483  620 AAERIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRLRSEAAAEAErLKSEAQESADRVRAEAAAAAERVGTEAAE 699

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  942 KEGKDQELAKLRGQEAaqrtelkelQQTLEHLKTQlVKKEKEQHPAGStggEE--ASA----PEAQLETVRKTEAPDPEV 1015
Cdd:NF041483  700 ALAAAQEEAARRRREA---------EETLGSARAE-ADQERERAREQS---EEllASArkrvEEAQAEAQRLVEEADRRA 766

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1016 EALraeVSKLEQQCQQQKQQVEGLTHSLESERAS-RAEQDKALETLQGQLEEKTQELghsqAASASAQREltalhakaqd 1094
Cdd:NF041483  767 TEL---VSAAEQTAQQVRDSVAGLQEQAEEEIAGlRSAAEHAAERTRTEAQEEADRV----RSDAYAERE---------- 829

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1095 hsKAEEEwkaqVARGQQEAERKSSLISSLEEevsilnRQVLEKEGESkelKRLVVAESEKSQkleeRLRLLQVETASSSA 1174
Cdd:NF041483  830 --RASED----ANRLRREAQEETEAAKALAE------RTVSEAIAEA---ERLRSDASEYAQ----RVRTEASDTLASAE 890

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1175 RAAERSSA-LREEVQSLREEVEKQrviSENLRQELTSQAER----AEELGQELKAWQEKFFQKEQALSALQLEHTSTQAL 1249
Cdd:NF041483  891 QDAARTRAdAREDANRIRSDAAAQ---ADRLIGEATSEAERltaeARAEAERLRDEARAEAERVRADAAAQAEQLIAEAT 967

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1250 V-SELLPAKhlcqqlqaeqaaaekrHREEIEQSKQAAGGLRAELMRAqrelgelgplrqkVAEQERAAQQLRAEKASYAE 1328
Cdd:NF041483  968 GeAERLRAE----------------AAETVGSAQQHAERIRTEAERV-------------KAEAAAEAERLRTEAREEAD 1018

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1329 QLsmLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEM----RQEAQSTTRELEV---- 1400
Cdd:NF041483 1019 RT--LDEARKDANKRRSEAAEQADTLITEAAAEADQLTAKAQEEALRTTTEAEAQADTMvgaaRKEAERIVAEATVegns 1096

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1401 -----MTAKYE---GAKVKVLEERQRFQEERQKLTAQVEELSKKLT-EYDQASKVQQQK----LKAFQAQGGESQQEVQR 1467
Cdd:NF041483 1097 lvekaRTDADEllvGARRDATAIRERAEELRDRITGEIEELHERARrESAEQMKSAGERcdalVKAAEEQLAEAEAKAKE 1176

                        1210      1220      1230      1240      1250      1260      1270
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178 1468 LQAQLNELQTQLS----------QKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAER 1533
Cdd:NF041483 1177 LVSDANSEASKVRiaavkkaeglLKEAEQKKAELVREAEKIKAEAEAEAKRTVEEGKRELDVLVRRREDINAEISR 1252
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1116-1567 2.47e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.88  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1116 KSSLISSLEEEV-SILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQ--VETASSSARAAERSSALREEVQSLRE 1192
Cdd:COG4717    44 RAMLLERLEKEAdELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEelEELEEELEELEAELEELREELEKLEK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1193 EVEKQRVISE--NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHlcqQLQAEQAAA 1270
Cdd:COG4717   124 LLQLLPLYQEleALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATE---EELQDLAEE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1271 EKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAaQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1350
Cdd:COG4717   201 LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERL-KEARLLLLIAAALLALLGLGGSLLSLILTIAGVL 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1351 ANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQrfqEERQKLTAQV 1430
Cdd:COG4717   280 FLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRI---EELQELLREA 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1431 EELSKKLtEYDQASKVQQQKLKAFQA-------QGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAkthydak 1503
Cdd:COG4717   357 EELEEEL-QLEELEQEIAALLAEAGVedeeelrAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEE------- 428

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178 1504 kQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTK--EAEQACRHLSAQVRSLEAQVA 1567
Cdd:COG4717   429 -ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGElaELLQELEELKAELRELAEEWA 493
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1015-1500 2.51e-12

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 72.88  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1015 VEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALhAKAQD 1094
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKL-EKLLQ 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1095 HSKAEEEWkaqvargqQEAERKsslISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSA 1174
Cdd:COG4717   127 LLPLYQEL--------EALEAE---LAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1175 RAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQA-LSALQLEHTSTQALVSEL 1253
Cdd:COG4717   196 DLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAaLLALLGLGGSLLSLILTI 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1254 LPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELgplrqkVAEQERAAQQLRAEKASYAEQLSML 1333
Cdd:COG4717   276 AGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEEL------LAALGLPPDLSPEELLELLDRIEEL 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1334 KKAHGLLAEENRglgeranlgrqflEVELDQAREKYVQELAAVRTDAET---HLAEMRQEAQSTTRELEVMTAKYEGAKV 1410
Cdd:COG4717   350 QELLREAEELEE-------------ELQLEELEQEIAALLAEAGVEDEEelrAALEQAEEYQELKEELEELEEQLEELLG 416

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1411 KVLEERQRFQEERqkLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGG--ESQQEVQRLQAQLNELQTQLSQKEQAAEH 1488
Cdd:COG4717   417 ELEELLEALDEEE--LEEELEELEEELEELEEELEELREELAELEAELEqlEEDGELAELLQELEELKAELRELAEEWAA 494

                         490
                  ....*....|....*
gi 344240178 1489 YKLQ---MEKAKTHY 1500
Cdd:COG4717   495 LKLAlelLEEAREEY 509
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 167-778 3.60e-12

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 72.77  E-value: 3.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   167 RELEELRGKNESLTvRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEW 246
Cdd:TIGR00606  515 RKLRKLDQEMEQLN-HHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRL 593

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   247 AEkqthLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQEkgevlgdaLQLETLKQEAAKLAAHNTQLQAR 326
Cdd:TIGR00606  594 AK----LNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEE--------SDLERLKEEIEKSSKQRAMLAGA 661

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   327 IETLD--CERSQQEAQ---LLAERgHFEEEKQqLASLIADLQSSISNLSQAKEELEQASQAQgaqltaqvasltalnttl 401
Cdd:TIGR00606  662 TAVYSqfITQLTDENQsccPVCQR-VFQTEAE-LQEFISDLQSKLRLAPDKLKSTESELKKK------------------ 721

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   402 qQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAArQDHAQQLAIVAeare 481
Cdd:TIGR00606  722 -EKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESA-KVCLTDVTIME---- 795

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   482 aslrerdaaRQQLETLEKEKaaKLESLQQQLEAANEARdsvqtSVTQVQQEKAE-------LSQKIEELHACIeaahQEQ 554
Cdd:TIGR00606  796 ---------RFQMELKDVER--KIAQQAAKLQGSDLDR-----TVQQVNQEKQEkqheldtVVSKIELNRKLI----QDQ 855

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   555 RQAQAHVTELEAQLKAEQQKVAERekvMQEKAQLQEQLLALEETLQITKGSLEEEKHRTA-------DALAEQQRCVTKM 627
Cdd:TIGR00606  856 QEQIQHLKSKTNELKSEKLQIGTN---LQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSpletfleKDQQEKEELISSK 932

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   628 EAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEAlrrELAEATASQHRAESESEQLIREVESWQKRFEA 707
Cdd:TIGR00606  933 ETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKET---ELNTVNAQLEECEKHQEKINEDMRLMRQDIDT 1009

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178   708 RQQEEarysAMIQEQLAALKGDHE-KAGQEAQEEAVEVHGEGQIGEQQsplaQLHTTLARALQQVKEKEVRA 778
Cdd:TIGR00606 1010 QKIQE----RWLQDNLTLRKRENElKEVEEELKQHLKEMGQMQVLQMK----QEHQKLEENIDLIKRNHVLA 1073
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 155-729 4.26e-12

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 72.06  E-value: 4.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   155 LNEKQAASSQESRELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFND 234
Cdd:pfam05483  108 LQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   235 LT----------------------EEHNKASQEWaEKQTHLEKELSTALQDK---------KYLEEKN---------EIL 274
Cdd:pfam05483  188 LNnniekmilafeelrvqaenarlEMHFKLKEDH-EKIQHLEEEYKKEINDKekqvsllliQITEKENkmkdltfllEES 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   275 QGKLSQLEERASQQCESPAQ--EKGEVLGDALQ--LETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLlaerGHFEE 350
Cdd:pfam05483  267 RDKANQLEEKTKLQDENLKEliEKKDHLTKELEdiKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQM----EELNK 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   351 EKQQLASLIADLQSSISNLsqakEELEQASQAQgaqLTAQVASLTALNTTLQQQQDQ--ELASLKEQAKKEQAQMVQSLQ 428
Cdd:pfam05483  343 AKAAHSFVVTEFEATTCSL----EELLRTEQQR---LEKNEDQLKIITMELQKKSSEleEMTKFKNNKEVELEELKKILA 415

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   429 EQEQAAQGlRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETlEKEKAAKL--- 505
Cdd:pfam05483  416 EDEKLLDE-KKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEK-EKLKNIELtah 493

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   506 -------------ESLQQQLEAANEARD----------------SVQTSVTQVQQE----KAELSQKIEELHACIEAAHQ 552
Cdd:pfam05483  494 cdklllenkeltqEASDMTLELKKHQEDiinckkqeermlkqieNLEEKEMNLRDElesvREEFIQKGDEVKCKLDKSEE 573

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   553 EQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLlaLEETLQITKGSLEEEKHRTADALAeqqrcVTKMEAESR 632
Cdd:pfam05483  574 NARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEEL--HQENKALKKKGSAENKQLNAYEIK-----VNKLELELA 646

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   633 SLMEQREQ----EQKALEQEKAGRKGLearLQQLEEARQAETEALR----------RELAEATASQHRAESESEQLIREV 698
Cdd:pfam05483  647 SAKQKFEEiidnYQKEIEDKKISEEKL---LEEVEKAKAIADEAVKlqkeidkrcqHKIAEMVALMEKHKHQYDKIIEER 723

                          650       660       670
                   ....*....|....*....|....*....|.
gi 344240178   699 ESWQKRFEARQQEEARYSAMIQEQLAALKGD 729
Cdd:pfam05483  724 DSELGLYKNKEQEQSSAKAALEIELSNIKAE 754
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
533-1197 6.02e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 71.63  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  533 KAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETlqitKGSLEEEKHR 612
Cdd:PRK03918  171 IKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEEL----KEEIEELEKE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  613 TAdalaeqqrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETE--ALRRELAEATASQHRAESE 690
Cdd:PRK03918  247 LE-----------SLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEyiKLSEFYEEYLDELREIEKR 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  691 SEQLIREVESWQKRFEARQQEEARYSAM------IQEQLAALKGDHEkagqeAQEEAVEVhgEGQIGEQQSPLAQLhtTL 764
Cdd:PRK03918  316 LSRLEEEINGIEERIKELEEKEERLEELkkklkeLEKRLEELEERHE-----LYEEAKAK--KEELERLKKRLTGL--TP 386

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  765 ARALQQVKEKEVRAQKLADDLTTLQEKMAStskvaaclktlvLKAGEQQEMTSLELLKEPPG---AGNKESNwlEEQRGG 841
Cdd:PRK03918  387 EKLEKELEELEKAKEEIEEEISKITARIGE------------LKKEIKELKKAIEELKKAKGkcpVCGRELT--EEHRKE 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  842 PFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERgqqerevaRLTRERSQAQadlaQEKAAKAELEVRLQNTL 921
Cdd:PRK03918  453 LLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKES--------ELIKLKELAE----QLKELEEKLKKYNLEEL 520

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  922 NEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEaaqrTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASapeaq 1001
Cdd:PRK03918  521 EKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK----KKLAELEKKLDELEEELAELLKELEELGFESVEELE----- 591

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1002 lETVRKTEAPDPEVEALRAEVSKLEqqcqQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELghsqaasasa 1081
Cdd:PRK03918  592 -ERLKELEPFYNEYLELKDAEKELE----REEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKY---------- 656

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1082 qreltalhakaqdhskAEEEWKaqvaRGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRlvvaESEKSQKLEER 1161
Cdd:PRK03918  657 ----------------SEEEYE----ELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKE----ELEEREKAKKE 712

                         650       660       670
                  ....*....|....*....|....*....|....*.
gi 344240178 1162 LRLLQvetasssaRAAERSSALREEVQSLREEVEKQ 1197
Cdd:PRK03918  713 LEKLE--------KALERVEELREKVKKYKALLKER 740
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 333-750 6.23e-12

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 71.69  E-value: 6.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   333 ERSQQEAQLLAERGHFEEEKQQLASLIadlqssisnlsQAKEELEQASQAQGAQLTAQvASLTALNTTLQQQQDQELASL 412
Cdd:pfam17380  286 ERQQQEKFEKMEQERLRQEKEEKAREV-----------ERRRKLEEAEKARQAEMDRQ-AAIYAEQERMAMERERELERI 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   413 KEQAKKEQAQMVQslqeQEQAAQglrqqveQLSSSLKLKEQQLEEAAKDqEAARQDhaqqlaiVAEAREASLRERDAAR- 491
Cdd:pfam17380  354 RQEERKRELERIR----QEEIAM-------EISRMRELERLQMERQQKN-ERVRQE-------LEAARKVKILEEERQRk 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   492 --QQLETLEKEKAAKLESLQQQLEAANEARdsvQTSVTQVQQEKAELSQKIEELhacieaahqEQRQAQAHVTELEAQLK 569
Cdd:pfam17380  415 iqQQKVEMEQIRAEQEEARQREVRRLEEER---AREMERVRLEEQERQQQVERL---------RQQEEERKRKKLELEKE 482

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   570 AEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEK 649
Cdd:pfam17380  483 KRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKAT 562

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   650 AGRKGLEARLQQLEEARQ-AETEALRRELAEATASQ-----HRAESeSEQLIREVESWQKRFEARQQEEARYS-AMIQEQ 722
Cdd:pfam17380  563 EERSRLEAMEREREMMRQiVESEKARAEYEATTPITtikpiYRPRI-SEYQPPDVESHMIRFTTQSPEWATPSpATWNPE 641

                          410       420
                   ....*....|....*....|....*...
gi 344240178   723 LAALKGDHEKAGQEAQEEAVEVHGEGQI 750
Cdd:pfam17380  642 WNTVTAEEETPGIPIIHSQCQVNGECEL 669
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 305-739 6.48e-12

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 71.76  E-value: 6.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  305 QLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASL--IADLQSSISNLSQAKEELEQASQA 382
Cdd:PRK10246  427 RLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVktICEQEARIKDLEAQRAQLQAGQPC 506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  383 Q--GAQLTAQVASLTALNTTLQQ----QQDQELASLKEQAKKEQAQ---MVQSLQEQEQAAQGLRQQVEQLSS------- 446
Cdd:PRK10246  507 PlcGSTSHPAVEAYQALEPGVNQsrldALEKEVKKLGEEGAALRGQldaLTKQLQRDESEAQSLRQEEQALTQqwqavca 586

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  447 SLKLKEQQLEEAAkDQEAARQDHAQQLAIvaeareasLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSV 526
Cdd:PRK10246  587 SLNITLQPQDDIQ-PWLDAQEEHERQLRL--------LSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYALTL 657

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  527 TQVQQEKAELSQKIEElhACIEAAHQEQRQA-QAHVTELEA---QLKAEQQKVAEREKV-MQEKAQLQEQLLALEETLQI 601
Cdd:PRK10246  658 PQEDEEASWLATRQQE--AQSWQQRQNELTAlQNRIQQLTPlleTLPQSDDLPHSEETVaLDNWRQVHEQCLSLHSQLQT 735

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  602 TKGSLEEEKHRTADALAE-----QQRCVTKMEAESRSLME-----QREQEQKALEQEKAGRKGLEARLQQLEEARQAETE 671
Cdd:PRK10246  736 LQQQDVLEAQRLQKAQAQfdtalQASVFDDQQAFLAALLDeetltQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHRP 815

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  672 ALRRELAEATASQHRAESESEQLiREVESWQKrfEARQQeeARYSAMIQEQLAALKGDHEKAGQEAQE 739
Cdd:PRK10246  816 DGLDLTVTVEQIQQELAQLAQQL-RENTTRQG--EIRQQ--LKQDADNRQQQQALMQQIAQATQQVED 878
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 349-576 7.64e-12

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 69.79  E-value: 7.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  349 EEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQ--ELASLKEQAKKEQAQMVQS 426
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAElaELEKEIAELRAELEAQKEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  427 LQEQEQAAQGLRQQveqlsSSLKLkeqqLEEAAKDQEAARQdhAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLE 506
Cdd:COG4942   106 LAELLRALYRLGRQ-----PPLAL----LLSPEDFLDAVRR--LQYLKYLAPARREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  507 SLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVA 576
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 965-1549 1.33e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 70.52  E-value: 1.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   965 ELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLE 1044
Cdd:pfam05483   82 KLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLK 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1045 SERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQREL--TALHAKAQDHSKAEEEWKaQVARGQQEAERKsslISS 1122
Cdd:pfam05483  162 ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELrvQAENARLEMHFKLKEDHE-KIQHLEEEYKKE---IND 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1123 LEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRlLQVETASSSaraAERSSALREEVQSLREEVEKQRVISE 1202
Cdd:pfam05483  238 KEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK-LQDENLKEL---IEKKDHLTKELEDIKMSLQRSMSTQK 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1203 NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLpakhlcqqlqaeqaaaeKRHREEIEQSK 1282
Cdd:pfam05483  314 ALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELL-----------------RTEQQRLEKNE 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1283 QAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRAEKasyaEQLSMLKKAHGLLAEENRGLGERAnlgrqfleVEL 1362
Cdd:pfam05483  377 DQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAED----EKLLDEKKQFEKIAEELKGKEQEL--------IFL 444

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1363 DQAREKYVQELaavrtdaETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLE---ERQRFQEERQKLTAQ----VEELSK 1435
Cdd:pfam05483  445 LQAREKEIHDL-------EIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIEltaHCDKLLLENKELTQEasdmTLELKK 517

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1436 KLTEYDQASKVQQQKLKAFQA-QGGESQ--QEVQRLQAQL----NELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ 1508
Cdd:pfam05483  518 HQEDIINCKKQEERMLKQIENlEEKEMNlrDELESVREEFiqkgDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCN 597

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*
gi 344240178  1509 ELQDQL----RDLEQLQKENKELRAEAERLGRELQQAGLKTKEAE 1549
Cdd:pfam05483  598 NLKKQIenknKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLE 642
mukB PRK04863
chromosome partition protein MukB;
248-612 1.71e-11

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 70.76  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  248 EKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERAS---QQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQ 324
Cdd:PRK04863  286 EEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESdleQDYQAASDHLNLVQTALRQQEKIERYQADLEELEERLE 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  325 ARIETLDcERSQQEAQLLAERGHFEEEKQQLASLIADLQSSI-------SNLSQAKEELEQASQ-AQGAQLTAqvASLTA 396
Cdd:PRK04863  366 EQNEVVE-EADEQQEENEARAEAAEEEVDELKSQLADYQQALdvqqtraIQYQQAVQALERAKQlCGLPDLTA--DNAED 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  397 LNTTLQ---QQQDQELASLKE-----QAKKEQ----AQMVQSLQ---EQEQAAQGLRQQVEQLSSSLKLKEQ--QLEEAA 459
Cdd:PRK04863  443 WLEEFQakeQEATEELLSLEQklsvaQAAHSQfeqaYQLVRKIAgevSRSEAWDVARELLRRLREQRHLAEQlqQLRMRL 522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  460 KDQEAARQDHAQQLAIVAEAREASLRERDAArQQLETLEKEKAAKLESLQQQLEAANEARdsvqtsvTQVQQEKAELSQK 539
Cdd:PRK04863  523 SELEQRLRQQQRAERLLAEFCKRLGKNLDDE-DELEQLQEELEARLESLSESVSEARERR-------MALRQQLEQLQAR 594

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  540 IEELhaciEAAHQEQRQAQAHVTELEAQLKAEQqkvAEREKVMQEKAQLQEQLLAL---EETLQITKGSLEEEKHR 612
Cdd:PRK04863  595 IQRL----AARAPAWLAAQDALARLREQSGEEF---EDSQDVTEYMQQLLERERELtveRDELAARKQALDEEIER 663
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 736-1506 1.80e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 70.38  E-value: 1.80e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   736 EAQEEAVEVHGEGQIGEQQSPLAQLHTTlaralQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEM 815
Cdd:TIGR00618  184 MEFAKKKSLHGKAELLTLRSQLLTLCTP-----CMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKK 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   816 TSL--ELLKEPPGAGNKESNwLEEQRGGPFSSPQAALKAMEQEA-EQMGSELERLRVALmksqgqqqeergqqEREVARL 892
Cdd:TIGR00618  259 QQLlkQLRARIEELRAQEAV-LEETQERINRARKAAPLAAHIKAvTQIEQQAQRIHTEL--------------QSKMRSR 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   893 TRERSQAQADLAQEkaAKAELEVRLQNTLNEQRVEFAalqEALDHALTEKEGKDQELAklrgqeaaQRTELKELQQTLEH 972
Cdd:TIGR00618  324 AKLLMKRAAHVKQQ--SSIEEQRRLLQTLHSQEIHIR---DAHEVATSIREISCQQHT--------LTQHIHTLQQQKTT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   973 LKTQL----VKKEKEQHPAGSTGGEEAS--APEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQvegltHSLESE 1046
Cdd:TIGR00618  391 LTQKLqslcKELDILQREQATIDTRTSAfrDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKI-----HLQESA 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1047 RASRA--EQDKALETLQGQLEEKTQELGHSQAASASAQRELTA----LHAKAQDHSKAE------EEWKAQVARGQQEAE 1114
Cdd:TIGR00618  466 QSLKEreQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGscihPNPARQDIDNPGpltrrmQRGEQTYAQLETSEE 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1115 RKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEV 1194
Cdd:TIGR00618  546 DVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQ 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1195 EKQRV------ISENLRQELTSQAERAEELGQE--LKAWQEKFFQKEQALSALQLEHTSTQALVSEL------LPAKHLC 1260
Cdd:TIGR00618  626 DLQDVrlhlqqCSQELALKLTALHALQLTLTQErvREHALSIRVLPKELLASRQLALQKMQSEKEQLtywkemLAQCQTL 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1261 QQLQAEQAAAEKRHREEIEQSKQAAGG-LRAELMRAQRELGELGPLRQKVAEQERAAQQLRAEKASYAEQL-SMLKKAHG 1338
Cdd:TIGR00618  706 LRELETHIEEYDREFNEIENASSSLGSdLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTgAELSHLAA 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1339 LLAEENRGLGERANLGRQfLEVELDQAREKYVQELaavrtDAETHLaeMRQEAQSTTRELEVMTAKYEGAK--VKVLEER 1416
Cdd:TIGR00618  786 EIQFFNRLREEDTHLLKT-LEAEIGQEIPSDEDIL-----NLQCET--LVQEEEQFLSRLEEKSATLGEIThqLLKYEEC 857

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1417 QRFQEERQKLTAQVEELSKKLTEYDQASkvqqqklkafqaqggeSQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKA 1496
Cdd:TIGR00618  858 SKQLAQLTQEQAKIIQLSDKLNGINQIK----------------IQFDGDALIKFLHEITLYANVRLANQSEGRFHGRYA 921

                          810
                   ....*....|
gi 344240178  1497 KTHYDAKKQQ 1506
Cdd:TIGR00618  922 DSHVNARKYQ 931
growth_prot_Scy NF041483
polarized growth protein Scy;
320-1418 1.92e-11

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 70.24  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  320 NTQLQARIETLDCERSQQEAQLLAERgHFEEEKQQLASLIADL-QSSISNLSQAKEELEQASQAQGAQLTAQVASLTALN 398
Cdd:NF041483   80 NAQIQADQLRADAERELRDARAQTQR-ILQEHAEHQARLQAELhTEAVQRRQQLDQELAERRQTVESHVNENVAWAEQLR 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  399 TTLQQQQ-----------DQELASLKEQAKKEQAQMVQSLQEQEQAAqglRQQVEQLSSSLKLKEQQLEEAAKDQEAARQ 467
Cdd:NF041483  159 ARTESQArrlldesraeaEQALAAARAEAERLAEEARQRLGSEAESA---RAEAEAILRRARKDAERLLNAASTQAQEAT 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  468 DHAQQLaivaeaREASLRERDAARQQLETLEKekaAKLESLQQQLEAANEARDSVQTSVTQVQQEKAElsqkieELHACI 547
Cdd:NF041483  236 DHAEQL------RSSTAAESDQARRQAAELSR---AAEQRMQEAEEALREARAEAEKVVAEAKEAAAK------QLASAE 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  548 EAAHQEQRQAQAHVTEL--EAQLKAEQQKvAEREKVMQEKAQLQEQLLAlEETLQITKGSLEEEKHRTADALAEQQRCVT 625
Cdd:NF041483  301 SANEQRTRTAKEEIARLvgEATKEAEALK-AEAEQALADARAEAEKLVA-EAAEKARTVAAEDTAAQLAKAARTAEEVLT 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 KMEAESRSLMEQREQEQKALEQE---KAGRKGLEARLQ--QLEEARQAETEALRRELAEATASQHRAESESEQLIREV-- 698
Cdd:NF041483  379 KASEDAKATTRAAAEEAERIRREaeaEADRLRGEAADQaeQLKGAAKDDTKEYRAKTVELQEEARRLRGEAEQLRAEAva 458

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  699 ESWQKRFEAR-----QQEEARYSAmiQEQLAALKGDHEKAGQEAQEEAVEVHGEGqIGEQQSPLAQLHTTLARALQQVKE 773
Cdd:NF041483  459 EGERIRGEARreavqQIEEAARTA--EELLTKAKADADELRSTATAESERVRTEA-IERATTLRRQAEETLERTRAEAER 535

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  774 KEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESnwLEEQRGgpfSSPQAALKAM 853
Cdd:NF041483  536 LRAEAEEQAEEVRAAAERAARELREETERAIAARQAEAAEELTRLHTEAEERLTAAEEA--LADARA---EAERIRREAA 610

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  854 EQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAE-LEVRLQNTLNEQRVEFAALQ 932
Cdd:NF041483  611 EETERLRTEAAERIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRLRSEAAAEAErLKSEAQESADRVRAEAAAAA 690

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  933 EALDHALTEKEGKDQELAKLRGQEA-----AQRTELKE-----LQQTLEHLKTQLVKKEKEQ-------HPAGSTGGEEA 995
Cdd:NF041483  691 ERVGTEAAEALAAAQEEAARRRREAeetlgSARAEADQereraREQSEELLASARKRVEEAQaeaqrlvEEADRRATELV 770

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  996 SAPEAQLETVRKT-----EAPDPEVEALR------AEVSKLEQQCQQQKQQVEGLThslESERAS------RAEQDKALE 1058
Cdd:NF041483  771 SAAEQTAQQVRDSvaglqEQAEEEIAGLRsaaehaAERTRTEAQEEADRVRSDAYA---ERERASedanrlRREAQEETE 847

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1059 TLQGqLEEKTQELGHSQA------ASASAQRELT----ALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVS 1128
Cdd:NF041483  848 AAKA-LAERTVSEAIAEAerlrsdASEYAQRVRTeasdTLASAEQDAARTRADAREDANRIRSDAAAQADRLIGEATSEA 926

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1129 ILNRQVLEKEGE------SKELKRLVVAESEKSQKL-------EERLRLLQVETASSSARAAERssaLREEVQSLREEVE 1195
Cdd:NF041483  927 ERLTAEARAEAErlrdeaRAEAERVRADAAAQAEQLiaeatgeAERLRAEAAETVGSAQQHAER---IRTEAERVKAEAA 1003

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1196 KQrviSENLRQELTSQAERAEELGQELK-------AWQEKFFQKEQALSALQLEHTSTQalvsELLPAKHLCQQLQAEQA 1268
Cdd:NF041483 1004 AE---AERLRTEAREEADRTLDEARKDAnkrrseaAEQADTLITEAAAEADQLTAKAQE----EALRTTTEAEAQADTMV 1076

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1269 AAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAaQQLRAEKASYAEQLSmlKKAHGLLAEENRGLG 1348
Cdd:NF041483 1077 GAARKEAERIVAEATVEGNSLVEKARTDADELLVGARRDATAIRERA-EELRDRITGEIEELH--ERARRESAEQMKSAG 1153

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1349 ERANLGRQFLEVELDQAREKYVQ------------ELAAVRTdAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEER 1416
Cdd:NF041483 1154 ERCDALVKAAEEQLAEAEAKAKElvsdanseaskvRIAAVKK-AEGLLKEAEQKKAELVREAEKIKAEAEAEAKRTVEEG 1232


                  ..
gi 344240178 1417 QR 1418
Cdd:NF041483 1233 KR 1234
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1046-1539 4.08e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 68.91  E-value: 4.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1046 ERASRA---------EQDKALETLQGQLEEKTQELGHSQAASASAQR-ELTALHAKAQDHSKAEEEWKAQVARGQQEAER 1115
Cdd:PRK02224  169 ERASDArlgvervlsDQRGSLDQLKAQIEEKEEKDLHERLNGLESELaELDEEIERYEEQREQARETRDEADEVLEEHEE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1116 KSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSA---RAAERSSALREEVQSLRE 1192
Cdd:PRK02224  249 RREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDAdaeAVEARREELEDRDEELRD 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1193 EVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSEL---LPAKHLCQQLQAEQAA 1269
Cdd:PRK02224  329 RLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELeeeIEELRERFGDAPVDLG 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1270 AEKRHREEIEQSKQAAGG----LRAELMRAQ------RELGELG-------PL------------RQKVAEQERAAQQLR 1320
Cdd:PRK02224  409 NAEDFLEELREERDELREreaeLEATLRTARerveeaEALLEAGkcpecgqPVegsphvetieedRERVEELEAELEDLE 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1321 AEKASYAEQLSMLKKAHGLLAEENRgLGERANLGRQFLEVELDQAREKYVQeLAAVRTDAETHLAEMR-QEAQSTTRELE 1399
Cdd:PRK02224  489 EEVEEVEERLERAEDLVEAEDRIER-LEERREDLEELIAERRETIEEKRER-AEELRERAAELEAEAEeKREAAAEAEEE 566

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1400 VMTAKYEgakVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQ--- 1476
Cdd:PRK02224  567 AEEAREE---VAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEaef 643

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178 1477 -----TQLSQKEQAAEHYklqMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQ 1539
Cdd:PRK02224  644 deariEEAREDKERAEEY---LEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 391-644 4.15e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 67.87  E-value: 4.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  391 VASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHA 470
Cdd:COG4942     7 LALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  471 QqlaivaeareaslrerdaARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAA 550
Cdd:COG4942    87 E------------------LEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  551 HQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAE 630
Cdd:COG4942   149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228

                         250
                  ....*....|....
gi 344240178  631 SRSLMEQREQEQKA 644
Cdd:COG4942   229 IARLEAEAAAAAER 242
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1055-1576 5.42e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.51  E-value: 5.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1055 KALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQV 1134
Cdd:TIGR04523   40 KKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQK 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1135 LEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAaerssalreevqslrEEVEKQRvisENLRQELTSQAER 1214
Cdd:TIGR04523  120 NKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKY---------------NDLKKQK---EELENELNLLEKE 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1215 AEELGQELKAWQEKFFQKEQALSALQL---EHTSTQALVSELlpakhlcqqlqaeqAAAEKRHREEIEQSKQAAGGLRAE 1291
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLLKLELLLSNLKKkiqKNKSLESQISEL--------------KKQNNQLKDNIEKKQQEINEKTTE 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1292 LMRAQRELGELGPLRQKVAEQERAAQ-----------QLRAEKASYAEQLSMLK--KAHGLLAEENRGLGERANLGRQfL 1358
Cdd:TIGR04523  248 ISNTQTQLNQLKDEQNKIKKQLSEKQkeleqnnkkikELEKQLNQLKSEISDLNnqKEQDWNKELKSELKNQEKKLEE-I 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1359 EVELDQArEKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEgakvKVLEERQRFQEERQKLTAQVEELSKKLT 1438
Cdd:TIGR04523  327 QNQISQN-NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIE----KLKKENQSYKQEIKNLESQINDLESKIQ 401

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1439 EYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLR--- 1515
Cdd:TIGR04523  402 NQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINkik 481

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  1516 -DLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:TIGR04523  482 qNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDL 543
mukB PRK04863
chromosome partition protein MukB;
407-1217 7.78e-11

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 68.45  E-value: 7.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  407 QELASLKEQAKKEQ---AQMVQSLQEQEQAAQGLRQQVEQLSSSLKL------KEQQLEEAAKDQEAARQDHAQQLAIVA 477
Cdd:PRK04863  293 RELYTSRRQLAAEQyrlVEMARELAELNEAESDLEQDYQAASDHLNLvqtalrQQEKIERYQADLEELEERLEEQNEVVE 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  478 EAREaslrERDAARQQLETLEKEkaakLESLQQQLEAANEARDSVQTSVTQVQQEKaelsQKIEELHACIEAAHQEQRQA 557
Cdd:PRK04863  373 EADE----QQEENEARAEAAEEE----VDELKSQLADYQQALDVQQTRAIQYQQAV----QALERAKQLCGLPDLTADNA 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  558 QAHVTELEAQLKaeqqkvaerekvmqekaQLQEQLLALEETLQITkgslEEEKHRTADALAEQQRCVTKMEAE-----SR 632
Cdd:PRK04863  441 EDWLEEFQAKEQ-----------------EATEELLSLEQKLSVA----QAAHSQFEQAYQLVRKIAGEVSRSeawdvAR 499

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  633 SLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAEteALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEE 712
Cdd:PRK04863  500 ELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAE--RLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEA 577

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  713 ARYSAMIQEQLAALKGDHEKAGQEAQE-----EAVEVHGEgQIGEQQSPLAQLHTtlarALQQVKEKEVRAQKLADDLTT 787
Cdd:PRK04863  578 RERRMALRQQLEQLQARIQRLAARAPAwlaaqDALARLRE-QSGEEFEDSQDVTE----YMQQLLERERELTVERDELAA 652

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  788 LQEKMastskvaaclktlvlkagEQQemtsLELLKEPPGAGNKESNWLEEQRGG---------------PFSSpqAAL-- 850
Cdd:PRK04863  653 RKQAL------------------DEE----IERLSQPGGSEDPRLNALAERFGGvllseiyddvsledaPYFS--ALYgp 708

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  851 -----------KAMEQEAEQMG---------SELERLRVALMKSQGQQQEERGQQEREVARLTRERS------------- 897
Cdd:PRK04863  709 arhaivvpdlsDAAEQLAGLEDcpedlylieGDPDSFDDSVFSVEELEKAVVVKIADRQWRYSRFPEvplfgraarekri 788

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  898 ---QAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHAltekEGKDQELAKLRGQEAAQRTELKELQQTLEHLK 974
Cdd:PRK04863  789 eqlRAEREELAERYATLSFDVQKLQRLHQAFSRFIGSHLAVAFE----ADPEAELRQLNRRRVELERALADHESQEQQQR 864

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  975 TQLvKKEKEQhpagsTGGEEASAPEAQLETVrktEAPDPEVEALRAEVSKLEQQCQ------QQKQQVEGLTHSLESE-- 1046
Cdd:PRK04863  865 SQL-EQAKEG-----LSALNRLLPRLNLLAD---ETLADRVEEIREQLDEAEEAKRfvqqhgNALAQLEPIVSVLQSDpe 935

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1047 -----RASRAEQDKALETLQGQ------LEEKTQELGHSQAA-----SASAQRELTALHAKA-QDHSKAEEEWKAQVARG 1109
Cdd:PRK04863  936 qfeqlKQDYQQAQQTQRDAKQQafalteVVQRRAHFSYEDAAemlakNSDLNEKLRQRLEQAeQERTRAREQLRQAQAQL 1015

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1110 QQEAERKSSLISSLeeevSILNRQVLEKEGESKELKrlVVAESEksqkLEERLRllqvetasssARAAERSSALREEvQS 1189
Cdd:PRK04863 1016 AQYNQVLASLKSSY----DAKRQMLQELKQELQDLG--VPADSG----AEERAR----------ARRDELHARLSAN-RS 1074

                         890       900
                  ....*....|....*....|....*...
gi 344240178 1190 LREEVEKQRVISENLRQELTSQAERAEE 1217
Cdd:PRK04863 1075 RRNQLEKQLTFCEAEMDNLTKKLRKLER 1102
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 338-665 8.47e-11

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 68.44  E-value: 8.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  338 EAQLLAERGHFEEEKQqlaslIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQ-----DQELASL 412
Cdd:COG3096   285 ERALELRRELFGARRQ-----LAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVQTALRQQEkieryQEDLEEL 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  413 KEQAKkEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLK---------LKEQQ------------LEEA------------- 458
Cdd:COG3096   360 TERLE-EQEEVVEEAAEQLAEAEARLEAAEEEVDSLKsqladyqqaLDVQQtraiqyqqavqaLEKAralcglpdltpen 438

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  459 AKDQEAARQDHAQQLAIVAEAREASLRERDAARQQ----LETLEK-----EKAAKLESLQQQLEAANEARDSVQTsVTQV 529
Cdd:COG3096   439 AEDYLAAFRAKEQQATEEVLELEQKLSVADAARRQfekaYELVCKiagevERSQAWQTARELLRRYRSQQALAQR-LQQL 517

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  530 QQEKAELSQKIEELHACIEAA---HQEQRQAQAHVTELEAQLkAEQQkvAEREKVMQEKAQLQEQLLALEETLQITKGSL 606
Cdd:COG3096   518 RAQLAELEQRLRQQQNAERLLeefCQRIGQQLDAAEELEELL-AELE--AQLEELEEQAAEAVEQRSELRQQLEQLRARI 594

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  607 EEEKHRTADALAEQQRCVTKME------AESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEA 665
Cdd:COG3096   595 KELAARAPAWLAAQDALERLREqsgealADSQEVTAAMQQLLEREREATVERDELAARKQALESQ 659
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 466-859 1.10e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 68.06  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  466 RQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLES---LQQQLEAANEARDSVQTSVTQvqQEKAElsqkiee 542
Cdd:COG3096   280 RRELSERALELRRELFGARRQLAEEQYRLVEMARELEELSAResdLEQDYQAASDHLNLVQTALRQ--QEKIE------- 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  543 lhacieaahqeqrQAQAHVTELEAQLKAEQQKVAERekvmqekaqlQEQLLALEETLQITKGSLEEEKHRTAD---ALAE 619
Cdd:COG3096   351 -------------RYQEDLEELTERLEEQEEVVEEA----------AEQLAEAEARLEAAEEEVDSLKSQLADyqqALDV 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  620 QQRcvtkmeaesRSLmeQREQEQKALEQEKA-------GRKGLEARLQQLEEARQAETEAL-----RRELAEATASQHRA 687
Cdd:COG3096   408 QQT---------RAI--QYQQAVQALEKARAlcglpdlTPENAEDYLAAFRAKEQQATEEVleleqKLSVADAARRQFEK 476

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  688 ESES-EQLIREVESWQKRFEARQQ-EEARYSAMIQEQLAALKGDHEKAGQ--EAQEEAVEVHGE--GQIGEQQSPLAQLH 761
Cdd:COG3096   477 AYELvCKIAGEVERSQAWQTARELlRRYRSQQALAQRLQQLRAQLAELEQrlRQQQNAERLLEEfcQRIGQQLDAAEELE 556

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  762 TTLARALQQVKEKEVRAQKLADDLTTLQekmastskvaaclKTLVLKAGEQQEMTSlellKEPPG-AGNKESNWLEEQRG 840
Cdd:COG3096   557 ELLAELEAQLEELEEQAAEAVEQRSELR-------------QQLEQLRARIKELAA----RAPAWlAAQDALERLREQSG 619

                         410
                  ....*....|....*....
gi 344240178  841 GPFSSPQAALKAMEQEAEQ 859
Cdd:COG3096   620 EALADSQEVTAAMQQLLER 638
PRK11637 PRK11637
AmiB activator; Provisional
 491-714 1.15e-10

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 66.64  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  491 RQQLETLEKEKAAKLESLQQ----------QLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQah 560
Cdd:PRK11637   46 RDQLKSIQQDIAAKEKSVRQqqqqrasllaQLKKQEEAISQASRKLRETQNTLNQLNKQIDELNASIAKLEQQQAAQE-- 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  561 vTELEAQLKA--EQQKVAEREKVMQ-EKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQ 637
Cdd:PRK11637  124 -RLLAAQLDAafRQGEHTGLQLILSgEESQRGERILAYFGYLNQARQETIAELKQTREELAAQKAELEEKQSQQKTLLYE 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  638 REQEQKALEQEKAGRK----GLEARL----QQLEEARQAETEaLRRELAEA-TASQHRAESESeqliREVEswqkRFEAR 708
Cdd:PRK11637  203 QQAQQQKLEQARNERKktltGLESSLqkdqQQLSELRANESR-LRDSIARAeREAKARAEREA----REAA----RVRDK 273


                  ....*.
gi 344240178  709 QQEEAR 714
Cdd:PRK11637  274 QKQAKR 279
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 79-378 1.26e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.79  E-value: 1.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    79 ASSSSENNFLSGSPSSP-MGDILQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIdhlallne 157
Cdd:TIGR02169  661 APRGGILFSRSEPAELQrLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEE-------- 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   158 kqaasSQESRELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLsfKVREFASHLQQLQGAFNDLTE 237
Cdd:TIGR02169  733 -----EKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL--EARLSHSRIPEIQAELSKLEE 805

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   238 EHnkasQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCEspaqekgEVLGDALQLETLKQEAAKLA 317
Cdd:TIGR02169  806 EV----SRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEK-------EIENLNGKKEELEEELEELE 874

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178   318 AHNTQLQARIETLDCERSQQEAQLlaerGHFEEEKQQLASLIADLQSSISNLSQAKEELEQ 378
Cdd:TIGR02169  875 AALRDLESRLGDLKKERDELEAQL----RELERKIEELEAQIEKKRKRLSELKAKLEALEE 931
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 523-739 1.35e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.94  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLALEETLQIT 602
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALE---QELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  603 KGSLEEEKHRTADALAEQQRcvtkmeaesrslMEQREQEQKALEQEKAGRKGLEAR-LQQLEEARQAETEALRRELAEAT 681
Cdd:COG4942    96 RAELEAQKEELAELLRALYR------------LGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELA 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178  682 ASQHRAESESEQL---IREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQE 739
Cdd:COG4942   164 ALRAELEAERAELealLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEE 224
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 305-689 1.40e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 67.67  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  305 QLETLKQEAAKLAAHNTQLQARIEtlDCER-SQQEAQLLAERGH--FEEEKQQLASLIADLQSSISNLSQAKEELEQASQ 381
Cdd:COG3096   786 RLEELRAERDELAEQYAKASFDVQ--KLQRlHQAFSQFVGGHLAvaFAPDPEAELAALRQRRSELERELAQHRAQEQQLR 863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  382 AQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQqVEQLSSSLKLKEQQLEEAAKD 461
Cdd:COG3096   864 QQLDQLKEQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAFIQQHGKALAQ-LEPLVAVLQSDPEQFEQLQAD 942

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  462 QEAA--RQDHAQQ----LAIVAEAREAsLRERDAARQQLETlekekAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAE 535
Cdd:COG3096   943 YLQAkeQQRRLKQqifaLSEVVQRRPH-FSYEDAVGLLGEN-----SDLNEKLRARLEQAEEARREAREQLRQAQAQYSQ 1016

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  536 LSQKIEELHACIEAAHQEQRQAQAHVTELEAQL--KAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKgsleeekhrt 613
Cdd:COG3096  1017 YNQVLASLKSSRDAKQQTLQELEQELEELGVQAdaEAEERARIRRDELHEELSQNRSRRSQLEKQLTRCE---------- 1086

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  614 adalAEQQRCVTKMEAESRSLMEQREQeqkaLEQEKAGRkgleARLQQLEEARQAETEALRRELAEATASQHRAES 689
Cdd:COG3096  1087 ----AEMDSLQKRLRKAERDYKQEREQ----VVQAKAGW----CAVLRLARDNDVERRLHRRELAYLSADELRSMS 1150
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 504-756 1.46e-10

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 66.01  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  504 KLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQ 583
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  584 EK--------------------------AQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQ 637
Cdd:COG3883    97 RSggsvsyldvllgsesfsdfldrlsalSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  638 REQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSA 717
Cdd:COG3883   177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAG 256

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 344240178  718 MIQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSP 756
Cdd:COG3883   257 AAAGSAGAAGAAAGAAGAGAAAASAAGGGAGGAGGGGGG 295
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1133-1609 1.48e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.37  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1133 QVLEKEgeSKEL-KRLVVAESEKSQKLEERLRL-LQVETASSSARAA----ERSSALREEVQSLREEVEK-QRVIS---- 1201
Cdd:PRK02224  195 QIEEKE--EKDLhERLNGLESELAELDEEIERYeEQREQARETRDEAdevlEEHEERREELETLEAEIEDlRETIAeter 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1202 --ENLRQELTSQAERAEELGQELkawqekffqkEQALSALQLEHTSTQAL---VSELLPAKHLCQQLQAEQAAAEKRHRE 1276
Cdd:PRK02224  273 erEELAEEVRDLRERLEELEEER----------DDLLAEAGLDDADAEAVearREELEDRDEELRDRLEECRVAAQAHNE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1277 EIEQSKQAAGGLRAELMRAQRELGELGplrQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERanlgRQ 1356
Cdd:PRK02224  343 EAESLREDADDLEERAEELREEAAELE---SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDF----LE 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1357 FLEVELDQAREKyVQELAAVRTDAETHLAEMRQ---EAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEEL 1433
Cdd:PRK02224  416 ELREERDELRER-EAELEATLRTARERVEEAEAlleAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEV 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1434 SKKLTEYDQASKVQQQ------------KLKAFQAQGGESQQE-VQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTH- 1499
Cdd:PRK02224  495 EERLERAEDLVEAEDRierleerredleELIAERRETIEEKRErAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEv 574

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1500 --YDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQ-----VAHADQQ 1572
Cdd:PRK02224  575 aeLNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEfdearIEEARED 654

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 344240178 1573 LRDLGKFQV-ATDALKSREPQKPQLDLSIDSLDLSLEE 1609
Cdd:PRK02224  655 KERAEEYLEqVEEKLDELREERDDLQAEIGAVENELEE 692
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 255-790 1.70e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 67.28  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  255 KELSTALQDKKYLEEKNEILQGKLSQLEERASQQCEspaqekgevlgdalqLETLKQEAAKlaAHNTQLQARIEtLDCER 334
Cdd:COG3096   498 RELLRRYRSQQALAQRLQQLRAQLAELEQRLRQQQN---------------AERLLEEFCQ--RIGQQLDAAEE-LEELL 559

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  335 SQQEAQLlaerghfEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQvaslTALNTtLQQQQDQELASLKE 414
Cdd:COG3096   560 AELEAQL-------EELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQ----DALER-LREQSGEALADSQE 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  415 QakkeQAQMvQSLQEQEQAAQGLRQQVEQlssslklKEQQLEEAAKDQEAARQDHAQQLAIVAE---------------- 478
Cdd:COG3096   628 V----TAAM-QQLLEREREATVERDELAA-------RKQALESQIERLSQPGGAEDPRLLALAErlggvllseiyddvtl 695

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  479 ------------AREA-SLRERDAARQQLETL-------------------------EKEKAAKLESLQQQLE------- 513
Cdd:COG3096   696 edapyfsalygpARHAiVVPDLSAVKEQLAGLedcpedlyliegdpdsfddsvfdaeELEDAVVVKLSDRQWRysrfpev 775

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  514 -----AANEAR-DSVQTSVTQVQQEKAELS---QKIEELH--------------------ACIEAAHQEQRQAQAHVTEL 564
Cdd:COG3096   776 plfgrAAREKRlEELRAERDELAEQYAKASfdvQKLQRLHqafsqfvgghlavafapdpeAELAALRQRRSELERELAQH 855

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  565 EAQLKAEQQKVAE-REKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRC---VTKMEAESRSLM---EQ 637
Cdd:COG3096   856 RAQEQQLRQQLDQlKEQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAFIQQHgkaLAQLEPLVAVLQsdpEQ 935

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  638 REQEQKALEQEKAGRKGLEARLQQLEEARQaETEALRRELAEATASQHRAESES-EQLIREVESWQKRF-EARQQEEARY 715
Cdd:COG3096   936 FEQLQADYLQAKEQQRRLKQQIFALSEVVQ-RRPHFSYEDAVGLLGENSDLNEKlRARLEQAEEARREArEQLRQAQAQY 1014

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  716 SAMIQEqLAALKGDHEKAGQEAQE-----EAVEVHG---------------EGQIGEQQSPLAQLHTTLARALQQVKEKE 775
Cdd:COG3096  1015 SQYNQV-LASLKSSRDAKQQTLQEleqelEELGVQAdaeaeerarirrdelHEELSQNRSRRSQLEKQLTRCEAEMDSLQ 1093

                         650
                  ....*....|....*
gi 344240178  776 VRAQKLADDLTTLQE 790
Cdd:COG3096  1094 KRLRKAERDYKQERE 1108
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 269-483 2.22e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.56  E-value: 2.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  269 EKNEILQGKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHF 348
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  349 EEEKQQLASLIADLQS-----------SISNLSQAK------EELEQASQAQGAQLTAQVASLTALNTTLQQQQdQELAS 411
Cdd:COG4942   100 EAQKEELAELLRALYRlgrqpplalllSPEDFLDAVrrlqylKYLAPARREQAEELRADLAELAALRAELEAER-AELEA 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  412 LKEQAKKEQAQMVQSLQEQEQAaqglrqqVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREAS 483
Cdd:COG4942   179 LLAELEEERAALEALKAERQKL-------LARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 749-1575 2.41e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 66.61  E-value: 2.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   749 QIGEQQSPLAQLHTTLARALQQVKEKevrAQKLADDLTTLQEKMASTSKVAAC----LKTLVLKAGEQQEMTS------- 817
Cdd:TIGR00606  193 QVRQTQGQKVQEHQMELKYLKQYKEK---ACEIRDQITSKEAQLESSREIVKSyeneLDPLKNRLKEIEHNLSkimkldn 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   818 -LELLKEPPGAGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRE- 895
Cdd:TIGR00606  270 eIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEq 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   896 -RSQAQADLAQEKAAKAELEvRLQNTLneqRVEFAALQEAldhALTEKEGKDQELAKLRGQEAAQRT---ELKELQQTLE 971
Cdd:TIGR00606  350 gRLQLQADRHQEHIRARDSL-IQSLAT---RLELDGFERG---PFSERQIKNFHTLVIERQEDEAKTaaqLCADLQSKER 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   972 HLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQ---------QVEGLTHS 1042
Cdd:TIGR00606  423 LKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERelskaeknsLTETLKKE 502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1043 LESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEE---------WKAQVargQQEA 1113
Cdd:TIGR00606  503 VKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDEltsllgyfpNKKQL---EDWL 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1114 ERKSSLISSLEEEVSILNRQVLEKEGE----SKELKRLVVAESEKSQKL---------EERLRLLQVETASSSARAAERS 1180
Cdd:TIGR00606  580 HSKSKEINQTRDRLAKLNKELASLEQNknhiNNELESKEEQLSSYEDKLfdvcgsqdeESDLERLKEEIEKSSKQRAMLA 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1181 SA----------LREEVQS--------LREEVEKQRVISEnLRQELTSQAERAEELGQELKAWQEKffqKEQALSALQLE 1242
Cdd:TIGR00606  660 GAtavysqfitqLTDENQSccpvcqrvFQTEAELQEFISD-LQSKLRLAPDKLKSTESELKKKEKR---RDEMLGLAPGR 735

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1243 HTSTQALVSELLPAKHlcqqLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQ----------KVAEQ 1312
Cdd:TIGR00606  736 QSIIDLKEKEIPELRN----KLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERfqmelkdverKIAQQ 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1313 ---------ERAAQQLRAEKASYAEQLSMLKKAhgllAEENRGLGERANLGRQFLEVELDQAREKYVQ--ELAAVRTDAE 1381
Cdd:TIGR00606  812 aaklqgsdlDRTVQQVNQEKQEKQHELDTVVSK----IELNRKLIQDQQEQIQHLKSKTNELKSEKLQigTNLQRRQQFE 887

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1382 THLAEMRQEAQSTTRELEVMTAK---YEGAKVKVLEERQ----RFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLkaf 1454
Cdd:TIGR00606  888 EQLVELSTEVQSLIREIKDAKEQdspLETFLEKDQQEKEelisSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKI--- 964

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1455 qaQGGESQQEVQRlQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLrdleQLQKENKELRAEAERL 1534
Cdd:TIGR00606  965 --QDGKDDYLKQK-ETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNL----TLRKRENELKEVEEEL 1037

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  1535 GRELQQAG-LKTKEAEQACRHLSAQVRSL--------------EAQVAHADQQLRD 1575
Cdd:TIGR00606 1038 KQHLKEMGqMQVLQMKQEHQKLEENIDLIkrnhvlalgrqkgyEKEIKHFKKELRE 1093
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 847-1550 2.77e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 66.53  E-value: 2.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   847 QAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKaELEVRLQnTLNEQRV 926
Cdd:TIGR00618  200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLK-QLRARIE-ELRAQEA 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   927 EFAALQEALDHAltekegkdQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQ--LET 1004
Cdd:TIGR00618  278 VLEETQERINRA--------RKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRrlLQT 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1005 VRKTE---APDPEVEAL-RAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKaLETLQGQLEEKTQEL----GHSQA 1076
Cdd:TIGR00618  350 LHSQEihiRDAHEVATSiREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDI-LQREQATIDTRTSAFrdlqGQLAH 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1077 ASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLvvaeSEKSQ 1156
Cdd:TIGR00618  429 AKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLEL----QEEPC 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1157 KLEERLRLLQVEtasssARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1236
Cdd:TIGR00618  505 PLCGSCIHPNPA-----RQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1237 SALQLEHTSTQALVSELLPAKhlcqqlqaeqaaaekrhREEIEQSKQAAGGLRAELMRAQRELGELgPLRQKVAEQERAA 1316
Cdd:TIGR00618  580 NRSKEDIPNLQNITVRLQDLT-----------------EKLSEAEDMLACEQHALLRKLQPEQDLQ-DVRLHLQQCSQEL 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1317 QQLRAEKASYAEQLSMLKKAHGLLAeeNRGLGERANLGRQFLEveldQAREKYVQELAAVRTDAETHLAEMRQEAQS--- 1393
Cdd:TIGR00618  642 ALKLTALHALQLTLTQERVREHALS--IRVLPKELLASRQLAL----QKMQSEKEQLTYWKEMLAQCQTLLRELETHiee 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1394 TTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLN 1473
Cdd:TIGR00618  716 YDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLRE 795

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  1474 ELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQnqELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQ 1550
Cdd:TIGR00618  796 EDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQ--EEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAK 870
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
480-974 2.99e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.94  E-value: 2.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  480 REASLRERDAARQQLETLEkEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEelhacIEAAHQEQRQAQA 559
Cdd:COG4717    66 PELNLKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ-----LLPLYQELEALEA 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  560 HVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQitkgsleeekhrtadalAEQQRCVTKMEAESRSLMEQRE 639
Cdd:COG4717   140 ELAELPERLEELEERLEELRELEEELEELEAELAELQEELE-----------------ELLEQLSLATEEELQDLAEELE 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  640 QEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMI 719
Cdd:COG4717   203 ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLV 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  720 QEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSplAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVA 799
Cdd:COG4717   283 LGLLALLFLLLAREKASLGKEAEELQALPALEELEE--EELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELE 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  800 ACLKTlvlkageQQEMTSLELLKEPPGAGNKES--NWLEEQRggpfsspqaALKAMEQEAEQMGSELERLRVALmkSQGQ 877
Cdd:COG4717   361 EELQL-------EELEQEIAALLAEAGVEDEEElrAALEQAE---------EYQELKEELEELEEQLEELLGEL--EELL 422

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  878 QQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRvefaalqeaLDHALTEKEGKDQELAKLRGQEA 957
Cdd:COG4717   423 EALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGE---------LAELLQELEELKAELRELAEEWA 493

                         490
                  ....*....|....*..
gi 344240178  958 AQRTELKELQQTLEHLK 974
Cdd:COG4717   494 ALKLALELLEEAREEYR 510
mukB PRK04863
chromosome partition protein MukB;
219-790 3.09e-10

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 66.52  E-value: 3.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  219 REFASHLQQLQGAFNDLTEEHNKasQEWAEKQ-THLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQEKG 297
Cdd:PRK04863  509 RHLAEQLQQLRMRLSELEQRLRQ--QQRAERLlAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQ 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  298 evlgdalQLETLKQEAAKLAAHNT---QLQARIETL------DCERSQQ-----EAQLLAERGhFEEEKQQLASLIADLQ 363
Cdd:PRK04863  587 -------QLEQLQARIQRLAARAPawlAAQDALARLreqsgeEFEDSQDvteymQQLLERERE-LTVERDELAARKQALD 658

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  364 SSISNLSQAK----EELEQASQAQGAQLTAQ-------------------------VASLTALNTTLQQQQD-QELASLK 413
Cdd:PRK04863  659 EEIERLSQPGgsedPRLNALAERFGGVLLSEiyddvsledapyfsalygparhaivVPDLSDAAEQLAGLEDcPEDLYLI 738

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  414 EQAKKEQAQMVQSLQEQEQA------AQGLR----------------QQVEQLSSSLKLKEQQLEEAAKDQ-------EA 464
Cdd:PRK04863  739 EGDPDSFDDSVFSVEELEKAvvvkiaDRQWRysrfpevplfgraareKRIEQLRAEREELAERYATLSFDVqklqrlhQA 818

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  465 ARQDHAQQLAIVAEAR-EASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQ-EKAELSQKIEE 542
Cdd:PRK04863  819 FSRFIGSHLAVAFEADpEAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLlADETLADRVEE 898

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  543 LHACIEAAHQEQR---QAQAHVTELEAQLKAEQQKvaerekvMQEKAQLQEQLLALEETLQITKgsleeekhRTADALAE 619
Cdd:PRK04863  899 IREQLDEAEEAKRfvqQHGNALAQLEPIVSVLQSD-------PEQFEQLKQDYQQAQQTQRDAK--------QQAFALTE 963

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  620 qqrcvtkmeaesrsLMEQR-----EQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRrelaeatasqhRAESESEQL 694
Cdd:PRK04863  964 --------------VVQRRahfsyEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLR-----------QAQAQLAQY 1018

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  695 IREVESWQKRFEARQQEEARysamIQEQLAALkGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEK 774
Cdd:PRK04863 1019 NQVLASLKSSYDAKRQMLQE----LKQELQDL-GVPADSGAEERARARRDELHARLSANRSRRNQLEKQLTFCEAEMDNL 1093

                         650
                  ....*....|....*.
gi 344240178  775 EVRAQKLADDLTTLQE 790
Cdd:PRK04863 1094 TKKLRKLERDYHEMRE 1109
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 137-676 3.56e-10

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 66.00  E-value: 3.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   137 EKDAQIAMMQQRIDHL-ALLNEKQAASSQESRELE-ELRGKNESLTVRLHETLKQCQNLKTekNQMDRKISQLSEE---- 210
Cdd:pfam10174  182 ERTRRIAEAEMQLGHLeVLLDQKEKENIHLREELHrRNQLQPDPAKTKALQTVIEMKDTKI--SSLERNIRDLEDEvqml 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   211 --NGDLSFKVRE--------FASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKeLSTALQDKKyleEKNEILQGKLSQ 280
Cdd:pfam10174  260 ktNGLLHTEDREeeikqmevYKSHSKFMKNKIDQLKQELSKKESELLALQTKLET-LTNQNSDCK---QHIEVLKESLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   281 LEERASQ-QCESPA-----QEKGEVLGD-ALQLETLKQEAAKLAAHNTQLQariETLDC-ERS----QQEAQLLAERghF 348
Cdd:pfam10174  336 KEQRAAIlQTEVDAlrlrlEEKESFLNKkTKQLQDLTEEKSTLAGEIRDLK---DMLDVkERKinvlQKKIENLQEQ--L 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   349 EEEKQQLASL---IADLQSSISNLSQAKEELEQASqaqgAQLTAQVASLTALNTTLQQQQDQELASLKEQAK--KEQAQM 423
Cdd:pfam10174  411 RDKDKQLAGLkerVKSLQTDSSNTDTALTTLEEAL----SEKERIIERLKEQREREDRERLEELESLKKENKdlKEKVSA 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   424 VQS-LQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAAR--QQLETLEKE 500
Cdd:pfam10174  487 LQPeLTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTNPEinDRIRLLEQE 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   501 KAA-KLESLQQQLEAanearDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLK---AEQQKVA 576
Cdd:pfam10174  567 VARyKEESGKAQAEV-----ERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKkkgAQLLEEA 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   577 EREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHR---TADALAEQQRCVTKMEAESRSLMEQR-EQEQKALE---QEK 649
Cdd:pfam10174  642 RRREDNLADNSQQLQLEELMGALEKTRQELDATKARlssTQQSLAEKDGHLTNLRAERRKQLEEIlEMKQEALLaaiSEK 721

                          570       580
                   ....*....|....*....|....*..
gi 344240178   650 AGRKGLEARLQQLEEARQAETEALRRE 676
Cdd:pfam10174  722 DANIALLELSSSKKKKTQEEVMALKRE 748
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1044-1611 5.02e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 65.58  E-value: 5.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1044 ESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELT-ALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISS 1122
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQeQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1123 LEEE-----------------VSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALRE 1185
Cdd:pfam01576   84 LEEEeersqqlqnekkkmqqhIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1186 EVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKffqkEQALSALQLEHTSTQALVSELlpakhlcqqlqa 1265
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQEL----EKAKRKLEGESTDLQEQIAEL------------ 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1266 eqaaaekrhREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRAEkasYAEQLSMLKKAHGLLAEENR 1345
Cdd:pfam01576  228 ---------QAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISE---LQEDLESERAARNKAEKQRR 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1346 GLGERANLGRQFLEVELD------QAREKYVQELAAVR-------TDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKV 1412
Cdd:pfam01576  296 DLGEELEALKTELEDTLDttaaqqELRSKREQEVTELKkaleeetRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANL 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1413 LEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQL---SQKEQAAEHY 1489
Cdd:pfam01576  376 EKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELesvSSLLNEAEGK 455

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1490 KLQMEKAKTHYDAKKQQNQEL-QDQLRDLEQLQKENKELRAEAERLGRELQqaglktkEAEQACRHLSAQVRSLEAQVAH 1568
Cdd:pfam01576  456 NIKLSKDVSSLESQLQDTQELlQEETRQKLNLSTRLRQLEDERNSLQEQLE-------EEEEAKRNVERQLSTLQAQLSD 528

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 344240178  1569 ADQQLRDLgkfqvaTDALKSREPQKPQLDLSIDSLDLSLEEGT 1611
Cdd:pfam01576  529 MKKKLEED------AGTLEALEEGKKRLQRELEALTQQLEEKA 565
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
106-539 5.25e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 5.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  106 QMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAASSQ---ESRELEELRGKNESLTVR 182
Cdd:COG4717    82 EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAElaeLPERLEELEERLEELREL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  183 LHETLKQCQNLKTEKNQMDRKISQLSEENgdlsfkvrefASHLQQLQGAFNDLTEEHNKASQEWAEkqthLEKELSTALQ 262
Cdd:COG4717   162 EEELEELEAELAELQEELEELLEQLSLAT----------EEELQDLAEELEELQQRLAELEEELEE----AQEELEELEE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  263 DKKYLEEKNEILqgklsQLEERASQQCESPAQEKG--EVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQ 340
Cdd:COG4717   228 ELEQLENELEAA-----ALEERLKEARLLLLIAAAllALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGK 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  341 LLAERGHFEE----EKQQLASLIADLQ-SSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQ 415
Cdd:COG4717   303 EAEELQALPAleelEEEELEELLAALGlPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVE 382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  416 AKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQ-EAARQDHAQQLAIVAEAREASLRERDAARQQL 494
Cdd:COG4717   383 DEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEElEEELEELEEELEELEEELEELREELAELEAEL 462

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 344240178  495 ETLEK-----EKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQK 539
Cdd:COG4717   463 EQLEEdgelaELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 958-1580 5.54e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 65.38  E-value: 5.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   958 AQRTELKELQQTLEHLK--TQLVKKEKEQHPAgSTGGEEASAPEAQLETVRKTEAPDP---EVEALRAEVSKLEQQCQQQ 1032
Cdd:TIGR00618  160 AKSKEKKELLMNLFPLDqyTQLALMEFAKKKS-LHGKAELLTLRSQLLTLCTPCMPDTyheRKQVLEKELKHLREALQQT 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1033 KQQVEGLTHSLESERASRAEQdKALETLQGQLEEKTQELghSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQE 1112
Cdd:TIGR00618  239 QQSHAYLTQKREAQEEQLKKQ-QLLKQLRARIEELRAQE--AVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1113 AERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAE--------------SEKSQKLEERLRLLQVETASSSARaaE 1178
Cdd:TIGR00618  316 LQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEihirdahevatsirEISCQQHTLTQHIHTLQQQKTTLT--Q 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1179 RSSALREEVQSLREEVEKQ--RVISENLRQELTSQAERAEELGQELKAWQEKFFQKE-----QALSALQLEHTSTQALVS 1251
Cdd:TIGR00618  394 KLQSLCKELDILQREQATIdtRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTaqcekLEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1252 ELLPAKHLCQQLQAEQAAAEKRHRE-------------EIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQ 1318
Cdd:TIGR00618  474 QLQTKEQIHLQETRKKAVVLARLLElqeepcplcgsciHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTS 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1319 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV------ELDQAREKYVQELAA--VRTDAETHLAEMRQE 1390
Cdd:TIGR00618  554 ERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRlqdlteKLSEAEDMLACEQHAllRKLQPEQDLQDVRLH 633

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1391 AQSTTRELEVMTAKYEGAKVKVLEERQR------------FQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQG 1458
Cdd:TIGR00618  634 LQQCSQELALKLTALHALQLTLTQERVRehalsirvlpkeLLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHI 713

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1459 GESQQEVQRLQAQLNELQTQLSQKEQAAEH-YKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRE 1537
Cdd:TIGR00618  714 EEYDREFNEIENASSSLGSDLAAREDALNQsLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRL 793

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1538 LQ--QAGLKTKEAE--QACRH----LSAQVRSLEAQVAHADQQLRDLGKFQ 1580
Cdd:TIGR00618  794 REedTHLLKTLEAEigQEIPSdediLNLQCETLVQEEEQFLSRLEEKSATL 844
mukB PRK04863
chromosome partition protein MukB;
205-973 6.17e-10

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 65.36  E-value: 6.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  205 SQLSEENGDLsfkvREFASHLQQLQGAFNDLTEEHNKASQewaekqtHLEKELsTALQdkkyLEEKNEILQGKLSQLEER 284
Cdd:PRK04863  300 RQLAAEQYRL----VEMARELAELNEAESDLEQDYQAASD-------HLNLVQ-TALR----QQEKIERYQADLEELEER 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  285 ASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQ-QEAQLLAERGH---------------- 347
Cdd:PRK04863  364 LEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQyQQAVQALERAKqlcglpdltadnaedw 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  348 ---FEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQ---GAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQA 421
Cdd:PRK04863  444 leeFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVrkiAGEVSRSEAWDVARELLRRLREQRHLAEQLQQLRMRLS 523

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  422 QMVQSLQEQeQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEK-- 499
Cdd:PRK04863  524 ELEQRLRQQ-QRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAAra 602

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  500 ----EKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAeqqkV 575
Cdd:PRK04863  603 pawlAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDEEIERLSQPGGSEDPRLNA----L 678

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  576 AER----------EKVMQEKA--------------------QLQEQLLALE---ETLQITKGSLEEEKHRTADAlAEQQR 622
Cdd:PRK04863  679 AERfggvllseiyDDVSLEDApyfsalygparhaivvpdlsDAAEQLAGLEdcpEDLYLIEGDPDSFDDSVFSV-EELEK 757

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  623 CVTKMEAEsRSLMEQREQEQKALeqekaGRKGLEARLQQLEEARQAETEalrrelaeatasqhraesESEQLIREVESWQ 702
Cdd:PRK04863  758 AVVVKIAD-RQWRYSRFPEVPLF-----GRAAREKRIEQLRAEREELAE------------------RYATLSFDVQKLQ 813

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  703 KRFEArqqeearYSAMIQEQLA-ALKGDHEKAGQEAQEEAVEVHGE-GQIGEQQSPLAQLHTTLARALQQVKEKEVRAQK 780
Cdd:PRK04863  814 RLHQA-------FSRFIGSHLAvAFEADPEAELRQLNRRRVELERAlADHESQEQQQRSQLEQAKEGLSALNRLLPRLNL 886

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  781 LADD-----LTTLQEKMASTSKVAACLKTLVlKAGEQQEmTSLELLKEPPgagnkesnwleeqrggpfsSPQAALKAMEQ 855
Cdd:PRK04863  887 LADEtladrVEEIREQLDEAEEAKRFVQQHG-NALAQLE-PIVSVLQSDP-------------------EQFEQLKQDYQ 945

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  856 EAEQMGSELERLRVALmksqgqqqeergqqEREVARLTR-ERSQAQADLAQEkaakAELEVRLQNTLNEQRVEFAALQEA 934
Cdd:PRK04863  946 QAQQTQRDAKQQAFAL--------------TEVVQRRAHfSYEDAAEMLAKN----SDLNEKLRQRLEQAEQERTRAREQ 1007

                         810       820       830
                  ....*....|....*....|....*....|....*....
gi 344240178  935 LDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHL 973
Cdd:PRK04863 1008 LRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDL 1046
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1108-1537 6.54e-10

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 64.76  E-value: 6.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1108 RGQQEAERKSS-LISSLEEEVSilnrQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSAL--- 1183
Cdd:pfam05557   27 RARIELEKKASaLKRQLDRESD----RNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKLNEKESQLada 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1184 REEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQlehTSTQALVSELLPAKHLcqql 1263
Cdd:pfam05557  103 REVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLE---KQQSSLAEAEQRIKEL---- 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1264 qaeqaaaeKRHREEIEQSKQAAGGLRAELMRaqrelgelgplrqkVAEQERAAQQLRAEKasyaEQLSMLKKAHGLLAEE 1343
Cdd:pfam05557  176 --------EFEIQSQEQDSEIVKNSKSELAR--------------IPELEKELERLREHN----KHLNENIENKLLLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1344 NRGLgeRANLGRQ--------FLEVELdqarEKYVQELAAVRTDAETHLAEMRQ-EAQST------TRELEVMTAKYE-G 1407
Cdd:pfam05557  230 VEDL--KRKLEREekyreeaaTLELEK----EKLEQELQSWVKLAQDTGLNLRSpEDLSRrieqlqQREIVLKEENSSlT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1408 AKVKVLEERQR-FQEERQKLTAQVEELSKKLTEYD-QASKVQQQKLKAFQAQGG-------------------------- 1459
Cdd:pfam05557  304 SSARQLEKARReLEQELAQYLKKIEDLNKKLKRHKaLVRRLQRRVLLLTKERDGyrailesydkeltmsnyspqllerie 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1460 ESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ--ELQDQLRDLEQLQKENKELRAEAERLGRE 1537
Cdd:pfam05557  384 EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESlaDPSYSKEEVDSLRRKLETLELERQRLREQ 463
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
895-1576 7.63e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.94  E-value: 7.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  895 ERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDH-----ALTEKEGKDQELAKLRGQEAAQRTELKELQQT 969
Cdd:COG4913   238 ERAHEALEDAREQIELLEPIRELAERYAAARERLAELEYLRAAlrlwfAQRRLELLEAELEELRAELARLEAELERLEAR 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  970 LEHLKTQL--VKKEKEQHpagstGGEeasapeaqletvrkteapdpEVEALRAEvskleqqcqqqkqqVEGLTHSLESER 1047
Cdd:COG4913   318 LDALREELdeLEAQIRGN-----GGD--------------------RLEQLERE--------------IERLERELEERE 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1048 ASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDhskAEEEWKAQVARGQQEAERKSSLISSLEEEV 1127
Cdd:COG4913   359 RRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEE---ALAEAEAALRDLRRELRELEAEIASLERRK 435

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1128 SILNRQVLekegeskELKRLVVAESEKSqklEERLR----LLQVETASSSAR-AAERssALREEVQSL--REEVEKQ--R 1198
Cdd:COG4913   436 SNIPARLL-------ALRDALAEALGLD---EAELPfvgeLIEVRPEEERWRgAIER--VLGGFALTLlvPPEHYAAalR 503

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1199 VI-SENLRQELTSQAERAEELGQELKAwqekfFQKEQALSALQLEHTSTQALVSELL--PAKHLCQqlqaeqaaaekrhr 1275
Cdd:COG4913   504 WVnRLHLRGRLVYERVRTGLPDPERPR-----LDPDSLAGKLDFKPHPFRAWLEAELgrRFDYVCV-------------- 564

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1276 EEIEQSKQAAGGL-RAELMRAQRELGELGPL-------------RQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLA 1341
Cdd:COG4913   565 DSPEELRRHPRAItRAGQVKGNGTRHEKDDRrrirsryvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQ 644

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1342 EENRGLGERANLgrQFLEVELDQAREKYV---QELAAVRTDAEThLAEMRQEAQSTTRELEVMTAKYEGAKvkvlEERQR 1418
Cdd:COG4913   645 ERREALQRLAEY--SWDEIDVASAEREIAeleAELERLDASSDD-LAALEEQLEELEAELEELEEELDELK----GEIGR 717

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1419 FQEERQKLTAQVEELSKKLTEYDQASKVQQQKL---KAFQAQGGESQQEVQR-LQAQLNELQTQLSQKEQAAEhykLQME 1494
Cdd:COG4913   718 LEKELEQAEEELDELQDRLEAAEDLARLELRALleeRFAAALGDAVERELREnLEERIDALRARLNRAEEELE---RAMR 794

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1495 KAKTHYDAkkqQNQELQDQLRDLEQLQKENKELRAEA-----ERLGRELQQAglKTKEAEQACRHLSAQVRSLEAQVAHA 1569
Cdd:COG4913   795 AFNREWPA---ETADLDADLESLPEYLALLDRLEEDGlpeyeERFKELLNEN--SIEFVADLLSKLRRAIREIKERIDPL 869


                  ....*..
gi 344240178 1570 DQQLRDL 1576
Cdd:COG4913   870 NDSLKRI 876
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1108-1542 8.29e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 64.97  E-value: 8.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1108 RGQQEAERKSSLISSLEEEVSILNRQVLEKEGE----SKELKRLVVAESEKSQKLE---ERLRLLQvetasSSARAAERS 1180
Cdd:COG3096   275 RHANERRELSERALELRRELFGARRQLAEEQYRlvemARELEELSARESDLEQDYQaasDHLNLVQ-----TALRQQEKI 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1181 SALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLC 1260
Cdd:COG3096   350 ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALEKARALC 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1261 QQLQAEQAAAEKRHREEIEQSKQAAGGLRAelmraqrelgelgpLRQKVAEQERAAQQlraekasYAEQLSMLKKAHGll 1340
Cdd:COG3096   430 GLPDLTPENAEDYLAAFRAKEQQATEEVLE--------------LEQKLSVADAARRQ-------FEKAYELVCKIAG-- 486

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1341 aeenrglgeranlgrqflEVELDQAREKYVQELAAVRTDAetHLAEMRQEAQSTTRELEVMTAKYEGAkvkvleerQRFQ 1420
Cdd:COG3096   487 ------------------EVERSQAWQTARELLRRYRSQQ--ALAQRLQQLRAQLAELEQRLRQQQNA--------ERLL 538

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1421 EERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKE-------QAAEHYKLQM 1493
Cdd:COG3096   539 EEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARApawlaaqDALERLREQS 618

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 344240178 1494 EKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAG 1542
Cdd:COG3096   619 GEALADSQEVTAAMQQLLEREREATVERDELAARKQALESQIERLSQPG 667
mukB PRK04863
chromosome partition protein MukB;
894-1578 9.80e-10

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 64.98  E-value: 9.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  894 RERSQAQADLAQEKAAKAELEV-RLQNTLN--EQRVEFA---ALQ-----EALDHALTEKEGKDQELAKLRGQEAAQRTE 962
Cdd:PRK04863  371 VEEADEQQEENEARAEAAEEEVdELKSQLAdyQQALDVQqtrAIQyqqavQALERAKQLCGLPDLTADNAEDWLEEFQAK 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  963 LKELQQTLEHLKTQLVKKE--KEQHPAG-----STGGEeASAPEAQ------LETVRKTEAPDPEVEALRAEVSKLEQQC 1029
Cdd:PRK04863  451 EQEATEELLSLEQKLSVAQaaHSQFEQAyqlvrKIAGE-VSRSEAWdvarelLRRLREQRHLAEQLQQLRMRLSELEQRL 529

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1030 QQQKQQVEGLTHSleSERASRAEQDKA-LETLQGQLEEKTQELgHSQAASASAQR-----ELTALHAKAQDHSKAEEEW- 1102
Cdd:PRK04863  530 RQQQRAERLLAEF--CKRLGKNLDDEDeLEQLQEELEARLESL-SESVSEARERRmalrqQLEQLQARIQRLAARAPAWl 606

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1103 KAQVARGQQEAERKSSLISSleEEVSILNRQVLEKEGESKELKRLVvaESEKSQKLEERLRLLQVETASSS--ARAAER- 1179
Cdd:PRK04863  607 AAQDALARLREQSGEEFEDS--QDVTEYMQQLLERERELTVERDEL--AARKQALDEEIERLSQPGGSEDPrlNALAERf 682

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1180 ------------------------------------SSALRE----------------EVQSLR------EEVEKQRVIS 1201
Cdd:PRK04863  683 ggvllseiyddvsledapyfsalygparhaivvpdlSDAAEQlagledcpedlyliegDPDSFDdsvfsvEELEKAVVVK 762

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1202 ENLRQELTSQ------------AERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVsellpAKHLcqqlqaeqaa 1269
Cdd:PRK04863  763 IADRQWRYSRfpevplfgraarEKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-----GSHL---------- 827

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1270 aekrhreeieqSKQAAGGLRAELMRAQRELGELGplrQKVAEQERAAQQLRAEKASYAEQLSMLKKAHG---LLAEENrg 1346
Cdd:PRK04863  828 -----------AVAFEADPEAELRQLNRRRVELE---RALADHESQEQQQRSQLEQAKEGLSALNRLLPrlnLLADET-- 891

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1347 LGERAnlgrQFLEVELDQARE--KYVQELAAVRTDAETHLAEMRQEAQsttrELEVMTAKYEGAkvkvlEERQRFQEERQ 1424
Cdd:PRK04863  892 LADRV----EEIREQLDEAEEakRFVQQHGNALAQLEPIVSVLQSDPE----QFEQLKQDYQQA-----QQTQRDAKQQA 958

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1425 KLTAQV---------EELSKKLTEYDQASKVQQQKLKafqaqggesqqevqRLQAQLNELQTQLSQKEQAAEHYKLQMEK 1495
Cdd:PRK04863  959 FALTEVvqrrahfsyEDAAEMLAKNSDLNEKLRQRLE--------------QAEQERTRAREQLRQAQAQLAQYNQVLAS 1024

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1496 AKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERlgRELQQAglkTKEAEQACRHLSAQVRSLEAQVAHADQQLRD 1575
Cdd:PRK04863 1025 LKSSYDAKRQMLQELKQELQDLGVPADSGAEERARARR--DELHAR---LSANRSRRNQLEKQLTFCEAEMDNLTKKLRK 1099


                  ...
gi 344240178 1576 LGK 1578
Cdd:PRK04863 1100 LER 1102
mukB PRK04863
chromosome partition protein MukB;
1124-1542 1.33e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 64.21  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1124 EEEVSILNRQVLEKEGESKELKRLVVAE-------SEKSQKLEERLRLLQVETASSSARAAERSSALR---------EEV 1187
Cdd:PRK04863  278 ANERRVHLEEALELRRELYTSRRQLAAEqyrlvemARELAELNEAESDLEQDYQAASDHLNLVQTALRqqekieryqADL 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1188 QSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQ 1267
Cdd:PRK04863  358 EELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQLCGLPDLTA 437

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1268 AAAEKRHREEIEQSKQAAGGLRAelmraqrelgelgpLRQKVAEQERAAQQlraekasYAEQLSMLKKAHGLLaeenrgl 1347
Cdd:PRK04863  438 DNAEDWLEEFQAKEQEATEELLS--------------LEQKLSVAQAAHSQ-------FEQAYQLVRKIAGEV------- 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1348 gERANLGRQFLEVELDQAREKYvqeLAAVRTDAETHLAEMRQEAQSTtRELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1427
Cdd:PRK04863  490 -SRSEAWDVARELLRRLREQRH---LAEQLQQLRMRLSELEQRLRQQ-QRAERLLAEFCKRLGKNLDDEDELEQLQEELE 564

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1428 AQVEELSKKLTEYDQASKVQQQKLKAFQAQGGE-SQQEVQRLQAQ--LNELQTQLSQkeqaaehyklqmekaktHYDAKK 1504
Cdd:PRK04863  565 ARLESLSESVSEARERRMALRQQLEQLQARIQRlAARAPAWLAAQdaLARLREQSGE-----------------EFEDSQ 627

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 344240178 1505 QQNQELQDQLRDLEQLQKENKELRAEAERLGRE---LQQAG 1542
Cdd:PRK04863  628 DVTEYMQQLLERERELTVERDELAARKQALDEEierLSQPG 668
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
593-1228 1.33e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.29  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  593 LALEETLQITKGSLEEEKHRTA--------DALAEQQRCVTKMEAESRSLMEQREQEQKALEQekagrkgLEARLQQLEE 664
Cdd:PRK02224  176 LGVERVLSDQRGSLDQLKAQIEekeekdlhERLNGLESELAELDEEIERYEEQREQARETRDE-------ADEVLEEHEE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  665 ARQaETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEearysamIQEQLAalkgdhEKAGQEAQEEAVEV 744
Cdd:PRK02224  249 RRE-ELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE-------RDDLLA------EAGLDDADAEAVEA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  745 HGEgqigEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKmastskvaaclktlvlkAGEQQEmtslellkep 824
Cdd:PRK02224  315 RRE----ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEER-----------------AEELRE---------- 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  825 pgagnkesnwleeqrggpfsspqaalkameqEAEQMGSELERLRVALmksqgqqqeergqqerevarltRERSQAQADLA 904
Cdd:PRK02224  364 -------------------------------EAAELESELEEAREAV----------------------EDRREEIEELE 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  905 QEKAAkaelevrlqntlNEQRVEFAAlqEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVK---KE 981
Cdd:PRK02224  391 EEIEE------------LRERFGDAP--VDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAgkcPE 456

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  982 KEQHPAGSTGGEEASAPEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEglthsLESERASRAEQDKALETLQ 1061
Cdd:PRK02224  457 CGQPVEGSPHVETIEEDRERVEELEA------ELEDLEEEVEEVEERLERAEDLVE-----AEDRIERLEERREDLEELI 525

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1062 GQLEEKTQElghsqaasasaQRE-LTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEvsilnRQVLEKEGE 1140
Cdd:PRK02224  526 AERRETIEE-----------KRErAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSK-----LAELKERIE 589

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1141 SKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVisENLRQELTSQAERAEELGQ 1220
Cdd:PRK02224  590 SLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARI--EEAREDKERAEEYLEQVEE 667


                  ....*...
gi 344240178 1221 ELKAWQEK 1228
Cdd:PRK02224  668 KLDELREE 675
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
300-534 1.34e-09

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 63.88  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  300 LGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAER-----GHFEEEKQQLASLIADLQSSisnLSQAKE 374
Cdd:COG3206   157 LAEAYLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRqknglVDLSEEAKLLLQQLSELESQ---LAEARA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  375 ELEQAsQAQGAQLTAQVAS-LTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKlkeQ 453
Cdd:COG3206   234 ELAEA-EARLAALRAQLGSgPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQ---Q 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  454 QLEEAAKDQEAARQdhaqqlaiVAEAREASLRER-DAARQQLETLeKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQE 532
Cdd:COG3206   310 EAQRILASLEAELE--------ALQAREASLQAQlAQLEARLAEL-PELEAELRRLEREVEVARELYESLLQRLEEARLA 380


                  ..
gi 344240178  533 KA 534
Cdd:COG3206   381 EA 382
mukB PRK04863
chromosome partition protein MukB;
341-713 1.37e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 64.21  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  341 LLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQ-----DQELASLKEQ 415
Cdd:PRK04863  284 HLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQQEkieryQADLEELEER 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  416 AkKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLK---------LKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRE 486
Cdd:PRK04863  364 L-EEQNEVVEEADEQQEENEARAEAAEEEVDELKsqladyqqaLDVQQTRAIQYQQAVQALERAKQLCGLPDLTADNAED 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  487 RDAarqQLETLEKEKAAKLESLQQQLEAANEARD-------SVQTSVTQVQQEKAElSQKIEELHACIEAAHQEQR--QA 557
Cdd:PRK04863  443 WLE---EFQAKEQEATEELLSLEQKLSVAQAAHSqfeqayqLVRKIAGEVSRSEAW-DVARELLRRLREQRHLAEQlqQL 518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  558 QAHVTELEAQLkaEQQKVAERekVMQEKAQLQEQLLALEETLQitkgSLEEEKHRTADALAEQQrcvtkmeaesRSLMEQ 637
Cdd:PRK04863  519 RMRLSELEQRL--RQQQRAER--LLAEFCKRLGKNLDDEDELE----QLQEELEARLESLSESV----------SEARER 580

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  638 REQEQKALEQEKAGRKGLEARLQQLEEArQAETEALRRELAEATASQHRAESE-SEQLIREVESWQKRFEARQQEEA 713
Cdd:PRK04863  581 RMALRQQLEQLQARIQRLAARAPAWLAA-QDALARLREQSGEEFEDSQDVTEYmQQLLERERELTVERDELAARKQA 656
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2231-2376 1.44e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2231 LLGAIQEGQLGIVQQLLESGSDAsgggplrnveESEDRSWREALNLAIRLGHEAITDVLL---ANIKFDFRQIHEALLVA 2307
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADV----------NARDKDGETPLHLAAYNGNLEIVKLLLeagADVNAQDNDGNTPLHLA 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178 2308 VDTNQPAVVRCLLarlerEKGRKVDTKSfslaffdssidgsrfAPGVTPLTLACQKDLYEIAQLLMDQG 2376
Cdd:COG0666   161 AANGNLEIVKLLL-----EAGADVNARD---------------NDGETPLHLAAENGHLEIVKLLLEAG 209
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 355-721 1.46e-09

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 63.16  E-value: 1.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   355 LASLIADLQSSISNLSQAKEELEQASqaqgaqltAQVASLTALNTTLQQQQDQelaslkeqAKKEQAQMVQSLQEQEQAA 434
Cdd:pfam19220   22 LRSLKADFSQLIEPIEAILRELPQAK--------SRLLELEALLAQERAAYGK--------LRRELAGLTRRLSAAEGEL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   435 QGLRQQVEQLSSSLKLKEQQLEEAA---KDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEK---EKAAKLESL 508
Cdd:pfam19220   86 EELVARLAKLEAALREAEAAKEELRielRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKalqRAEGELATA 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   509 QQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAH-VTELEAQLKAEQQKVAEREKVMQEKAQ 587
Cdd:pfam19220  166 RERLALLEQENRRLQALSEEQAAELAELTRRLAELETQLDATRARLRALEGQlAAEQAERERAEAQLEEAVEAHRAERAS 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   588 LQEQLLALEETLQITKGSLEEEKHRTADaLAEQQRCVTKMEAESRSLMEQREQEQKALEQEkagRKGLEARLQQLEEARQ 667
Cdd:pfam19220  246 LRMKLEALTARAAATEQLLAEARNQLRD-RDEAIRAAERRLKEASIERDTLERRLAGLEAD---LERRTQQFQEMQRARA 321

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178   668 AETE---ALRRELAEATASQHRAESESEQLIREVESWQKRFEA-RQQEEARYSAMIQE 721
Cdd:pfam19220  322 ELEEraeMLTKALAAKDAALERAEERIASLSDRIAELTKRFEVeRAALEQANRRLKEE 379
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1349-1594 1.68e-09

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 63.50  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1349 ERANLGRQFLEVELDQAREKYVQ-ELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1427
Cdd:COG3206   171 EEARKALEFLEEQLPELRKELEEaEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLG 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1428 AQVEEL-----SKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAehyklqMEKAKTHYDA 1502
Cdd:COG3206   251 SGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRI------LASLEAELEA 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1503 KKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQqaglkTKEAeqacRHLSAQVRSLEAQVAHADQQlrdlGKFQVA 1582
Cdd:COG3206   325 LQAREASLQAQLAQLEARLAELPELEAELRRLEREVE-----VARE----LYESLLQRLEEARLAEALTV----GNVRVI 391

                         250
                  ....*....|..
gi 344240178 1583 TDALKSREPQKP 1594
Cdd:COG3206   392 DPAVVPLKPVSP 403
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 297-646 1.77e-09

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 64.09  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  297 GEVLGDALQLETLKQEAAKLAAHNTQLQARIETL-DCERSQQEAQLLaerghfEEEKQQLASLIADLQSSISNLSQAKee 375
Cdd:NF012221 1528 GYILDNVVATSESSQQADAVSKHAKQDDAAQNALaDKERAEADRQRL------EQEKQQQLAAISGSQSQLESTDQNA-- 1599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  376 LEQASQAQGAQLTAQVASLTALNTTLQQQQDQelasLKEQAkkeQAQMVQSLQEQEQAAQGLRQQV-EQLSSSLKLKEQQ 454
Cdd:NF012221 1600 LETNGQAQRDAILEESRAVTKELTTLAQGLDA----LDSQA---TYAGESGDQWRNPFAGGLLDRVqEQLDDAKKISGKQ 1672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  455 LEEAakdqeaaRQDHAQQLAIVAEAreaslrerdaarqqletLEKEKAAKLESLQQQLEAaneaRDSVQTSVTQVQQEKA 534
Cdd:NF012221 1673 LADA-------KQRHVDNQQKVKDA-----------------VAKSEAGVAQGEQNQANA----EQDIDDAKADAEKRKD 1724

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  535 ElsqkieelhACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQ--EQLLALEETLQITKGSLEEEKHR 612
Cdd:NF012221 1725 D---------ALAKQNEAQQAESDANAAANDAQSRGEQDASAAENKANQAQADAKgaKQDESDKPNRQGAAGSGLSGKAY 1795

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 344240178  613 TADALAEQQ---RCVTKMEAESRSLMEQREQEQKALE 646
Cdd:NF012221 1796 SVEGVAEPGshiNPDSPAAADGRFSEGLTEQEQEALE 1832
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1112-1433 1.85e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.60  E-value: 1.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1112 EAERKSSLISSLEEEVSILNRQVLEKeGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLR 1191
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKAVSERQQQEK-FEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAME 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1192 EEVEKQRVISENLRQELtsQAERAEELGQELKAWQEkffqkeqaLSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE 1271
Cdd:pfam17380  346 RERELERIRQEERKREL--ERIRQEEIAMEISRMRE--------LERLQMERQQKNERVRQELEAARKVKILEEERQRKI 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1272 KRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAaQQLRAEKASYAEQlsmlKKAHGLLAEENRGLGERA 1351
Cdd:pfam17380  416 QQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQ-QQVERLRQQEEER----KRKKLELEKEKRDRKRAE 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1352 NLGRQFLEVELDQAREKYVQElaavRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1431
Cdd:pfam17380  491 EQRRKILEKELEERKQAMIEE----ERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERS 566


                   ..
gi 344240178  1432 EL 1433
Cdd:pfam17380  567 RL 568
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 303-519 1.92e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.47  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  303 ALQLETLKQEAAKLAAHNTQLQARIETLDcERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQA 382
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELEKELA-ALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  383 QGAQLTAQVASLTALNTTLQQQQDQ-ELASLKEQAKKEQA--------QMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQ 453
Cdd:COG4942    95 LRAELEAQKEELAELLRALYRLGRQpPLALLLSPEDFLDAvrrlqylkYLAPARREQAEELRADLAELAALRAELEAERA 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  454 QLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEkAAKLESLQQQLEAANEAR 519
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQE-AEELEALIARLEAEAAAA 239
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 100-704 2.39e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 63.27  E-value: 2.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   100 LQTPQFQMRRLKKQLADernnrDELELELSESLKLLTEKDAQIAMMQqridhlalLNEKQAASSQESRELEELRGKNESL 179
Cdd:pfam01576  519 LSTLQAQLSDMKKKLEE-----DAGTLEALEEGKKRLQRELEALTQQ--------LEEKAAAYDKLEKTKNRLQQELDDL 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   180 TVRLHETLKQCQNLktEKNQmdRKISQLSEENGDLSFKvrefashlqqlqgafndLTEEHNKASQEWAEKQTH---LEKE 256
Cdd:pfam01576  586 LVDLDHQRQLVSNL--EKKQ--KKFDQMLAEEKAISAR-----------------YAEERDRAEAEAREKETRalsLARA 644

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   257 LSTALQDKKYLEEKNEILQGKLSQLE-------------ERASQQCESPAQEKGEVLgDALQLETLKQEAAKL------- 316
Cdd:pfam01576  645 LEEALEAKEELERTNKQLRAEMEDLVsskddvgknvhelERSKRALEQQVEEMKTQL-EELEDELQATEDAKLrlevnmq 723

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   317 ---AAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTaQVAS 393
Cdd:pfam01576  724 alkAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVK-QLKK 802

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   394 LtalnttlqQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAakdqEAARQDHAQQL 473
Cdd:pfam01576  803 L--------QAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQA----QQERDELADEI 870

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   474 AIVAEAREASLRERDAARQQLETLEKEkaakLESLQQQLEAANearDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQE 553
Cdd:pfam01576  871 ASGASGKSALQDEKRRLEARIAQLEEE----LEEEQSNTELLN---DRLRKSTLQVEQLTTELAAERSTSQKSESARQQL 943

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   554 QRQAQahvtELEAQLKAEQQKVaeREKVMQEKAQLQEQLLALEETLQItkgsleEEKHRTADAlaeqqRCVTKMEAESRS 633
Cdd:pfam01576  944 ERQNK----ELKAKLQEMEGTV--KSKFKSSIAALEAKIAQLEEQLEQ------ESRERQAAN-----KLVRRTEKKLKE 1006

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   634 LMEQREQEQKALEQEKAGRKGLEARLQ----QLEEARQAETEA------LRRELAEATASqhraeseSEQLIREVESWQK 703
Cdd:pfam01576 1007 VLLQVEDERRHADQYKDQAEKGNSRMKqlkrQLEEAEEEASRAnaarrkLQRELDDATES-------NESMNREVSTLKS 1079


                   .
gi 344240178   704 R 704
Cdd:pfam01576 1080 K 1080
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 490-1240 2.98e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.21  E-value: 2.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   490 ARQQLETLEKEKAAKLESLQQQLEAANEARDS----VQTSVTQVQQEKAELSQKIEELHACIEAAHQEQR----QAQAHV 561
Cdd:pfam15921   72 GKEHIERVLEEYSHQVKDLQRRLNESNELHEKqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEdlrnQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   562 TELEAQlKAEQQKVAEREKVMQEkaQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTkmeAESRSLMEQREQE 641
Cdd:pfam15921  152 HELEAA-KCLKEDMLEDSNTQIE--QLRKMMLSHEGVLQEIRSILVDFEEASGKKIYEHDSMST---MHFRSLGSAISKI 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   642 QKALEQEKAGRKGleaRLQQLEEarqaETEALRRElaeatasqhrAESESEQLIreveswqkrfearQQEEARYSAMIQE 721
Cdd:pfam15921  226 LRELDTEISYLKG---RIFPVED----QLEALKSE----------SQNKIELLL-------------QQHQDRIEQLISE 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   722 QLAALKGDHEKAgQEAQEEAVEVHGEGQIGEQQSplaqlHTTLARALQQVKEKEVRAQKLADDLTtlQEKMASTSKVAAC 801
Cdd:pfam15921  276 HEVEITGLTEKA-SSARSQANSIQSQLEIIQEQA-----RNQNSMYMRQLSDLESTVSQLRSELR--EAKRMYEDKIEEL 347

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   802 LKTLVLKAGEQQEMtslellKEPPGAGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERlrvalmksqgqqqee 881
Cdd:pfam15921  348 EKQLVLANSELTEA------RTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDR--------------- 406

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   882 RGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDH--ALTEK-EGKDQELAKLRGQEAA 958
Cdd:pfam15921  407 DTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKvsSLTAQlESTKEMLRKVVEELTA 486

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   959 QRTELKELQQTLEHLKTQLVKKEkeqhpagstggeeasapeaqletvRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEG 1038
Cdd:pfam15921  487 KKMTLESSERTVSDLTASLQEKE------------------------RAIEATNAEITKLRSRVDLKLQELQHLKNEGDH 542

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1039 LTH---SLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQvargqqeAER 1115
Cdd:pfam15921  543 LRNvqtECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKIL-------KDK 615

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1116 KSSLISSLEEEVSILNrqvLEKegeskelKRLVVAESEKSQKL----EERLRLL-QVETAsssaraaerssalREEVQSL 1190
Cdd:pfam15921  616 KDAKIRELEARVSDLE---LEK-------VKLVNAGSERLRAVkdikQERDQLLnEVKTS-------------RNELNSL 672

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 344240178  1191 REEVEkqrVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQ 1240
Cdd:pfam15921  673 SEDYE---VLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSME 719
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 460-665 3.65e-09

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 61.75  E-value: 3.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  460 KDQEAARQDHAQQLAIVAEAREASLRERDAARQQ-LETLEKEKAAKLESLQQQLEAANEARDsvqtsvtqvQQEKAELSQ 538
Cdd:PRK09510   68 QQQQKSAKRAEEQRKKKEQQQAEELQQKQAAEQErLKQLEKERLAAQEQKKQAEEAAKQAAL---------KQKQAEEAA 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  539 KIEELHACIEAAHQEQR-QAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEEtlqiTKGSLEEEKHRTADAL 617
Cdd:PRK09510  139 AKAAAAAKAKAEAEAKRaAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAE----AKKKAEAEAKKKAAAE 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 344240178  618 AEQqrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEA 665
Cdd:PRK09510  215 AKK-----KAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAA 257
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 489-682 3.67e-09

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 59.94  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  489 AARQQLETLEKekaakLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQL 568
Cdd:COG1579     1 AMPEDLRALLD-----LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  569 KAEQQKvaerekvmQEKAQLQEQLLALEEtlqitkgsleeekhrtadALAEQQRCVTKMEAESRSLMEQREQEQKALEQE 648
Cdd:COG1579    76 KKYEEQ--------LGNVRNNKEYEALQK------------------EIESLKRRISDLEDEILELMERIEELEEELAEL 129

                         170       180       190
                  ....*....|....*....|....*....|....
gi 344240178  649 KAGRKGLEARLQQLEEARQAETEALRRELAEATA 682
Cdd:COG1579   130 EAELAELEAELEEKKAELDEELAELEAELEELEA 163
mukB PRK04863
chromosome partition protein MukB;
323-1150 3.89e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 62.67  E-value: 3.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  323 LQARIETLDCERSQQEAQ--LLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQ-----LTAQVASLT 395
Cdd:PRK04863  289 LELRRELYTSRRQLAAEQyrLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQQEKIERYQadleeLEERLEEQN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  396 ALNTTLQQQQDqELASLKEQAKKEQ-------AQMVQSLQEQE-------QAAQGLRQ-------------QVEQLSSSL 448
Cdd:PRK04863  369 EVVEEADEQQE-ENEARAEAAEEEVdelksqlADYQQALDVQQtraiqyqQAVQALERakqlcglpdltadNAEDWLEEF 447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  449 KLKEQQLEEAAKDQE-------AARQDHAQQLAIVAEAREASLRER--DAARQQLETLEKEK--AAKLESLQQQL----- 512
Cdd:PRK04863  448 QAKEQEATEELLSLEqklsvaqAAHSQFEQAYQLVRKIAGEVSRSEawDVARELLRRLREQRhlAEQLQQLRMRLseleq 527

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  513 -----EAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQ 587
Cdd:PRK04863  528 rlrqqQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAWLA 607

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  588 LQEQLLALEEtlqitkgsleeekhRTADALAEQQRCVtkmeaesrSLMEQREQEQKALEQEkagRKGLEARLQQLEEarQ 667
Cdd:PRK04863  608 AQDALARLRE--------------QSGEEFEDSQDVT--------EYMQQLLERERELTVE---RDELAARKQALDE--E 660

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  668 AEtEALRRELAEATASQHRAESESEQLIREVeswqkrFEARQQEEARY-SAM---------------IQEQLAALKG--- 728
Cdd:PRK04863  661 IE-RLSQPGGSEDPRLNALAERFGGVLLSEI------YDDVSLEDAPYfSALygparhaivvpdlsdAAEQLAGLEDcpe 733

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  729 ------------DHEKAGQEAQEEAVEVhgegQIGEQQSPLAQL--HTTLARAlqqvkEKEVRAQKLADDLTTLQEKMAS 794
Cdd:PRK04863  734 dlyliegdpdsfDDSVFSVEELEKAVVV----KIADRQWRYSRFpeVPLFGRA-----AREKRIEQLRAEREELAERYAT 804

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  795 TSKVAACLKTLVlKAGEQQEMTSLELLKEPpgagnkesnwleeqrggpfsSPQAALKAMEQEAEQMGSELERLRvalmks 874
Cdd:PRK04863  805 LSFDVQKLQRLH-QAFSRFIGSHLAVAFEA--------------------DPEAELRQLNRRRVELERALADHE------ 857

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  875 qgqqqeergqqerevarlTRERSQAQadlaQEKAAKAELevrlqntlneqrvefAALQEALDHA-LTEKEGKDQELAKLR 953
Cdd:PRK04863  858 ------------------SQEQQQRS----QLEQAKEGL---------------SALNRLLPRLnLLADETLADRVEEIR 900

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  954 GQ-EAAQRTE--LKELQQTLEHLKTQL--VKKEKEQHPAGSTGGEEAsapEAQLETVRKTEAPDPEVEALRAEVSKLEQQ 1028
Cdd:PRK04863  901 EQlDEAEEAKrfVQQHGNALAQLEPIVsvLQSDPEQFEQLKQDYQQA---QQTQRDAKQQAFALTEVVQRRAHFSYEDAA 977

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1029 CQQQKQQ--VEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQD---HSKAEEEWK 1103
Cdd:PRK04863  978 EMLAKNSdlNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDlgvPADSGAEER 1057

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178 1104 AQVARGQQEAE------RKSSL---ISSLEEEVSILNRQVLEKEGESKELKRLVVA 1150
Cdd:PRK04863 1058 ARARRDELHARlsanrsRRNQLekqLTFCEAEMDNLTKKLRKLERDYHEMREQVVN 1113
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 2672-2791 4.39e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 62.34  E-value: 4.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2672 LGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLNNIYVPyQETEKLGNFNE-------TFQfLFWTMFGMEEHTVVDMP 2743
Cdd:cd22192   447 LGPFTIMIQKIIfGDLMKFCWLMFVVILGFSSAFYMIFQT-EDPDSLGHFYDfpmtlfsTFE-LFLGLIDGPANYTVDLP 524

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 344240178 2744 QFLvpefvgRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWK 2791
Cdd:cd22192   525 FMY------KVLYTAFAVIAYLLMLNLLIAMMGDTHWRVAHERDELWR 566
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 631-1571 4.83e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 62.55  E-value: 4.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   631 SRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLireveswqkrfearqq 710
Cdd:pfam12128  264 HFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAL---------------- 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   711 eEARYSAMIQEQLAALKGDHEKAGQ-EAQEEAVEVHGEGQIGEQQSplaqlhttLARALQQVKEKevRAQKLADDLTTLQ 789
Cdd:pfam12128  328 -EDQHGAFLDADIETAAADQEQLPSwQSELENLEERLKALTGKHQD--------VTAKYNRRRSK--IKEQNNRDIAGIK 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   790 EKMASTSKVAACLKTLVLKAGEQQEmtslELLKEPPGAGNKESNwleeqrggpfsspqaalkameQEAEQMGSELERLRV 869
Cdd:pfam12128  397 DKLAKIREARDRQLAVAEDDLQALE----SELREQLEAGKLEFN---------------------EEEYRLKSRLGELKL 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   870 ALmksqgqqqeergqqerevarltrERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHAlteKEGKDQEL 949
Cdd:pfam12128  452 RL-----------------------NQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQA---RKRRDQAS 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   950 AKLRGQEAA---QRTELKELQQTL--------EHLKTQ----------------LVKKEKEQHPAGSTGGEEASAPEAQL 1002
Cdd:pfam12128  506 EALRQASRRleeRQSALDELELQLfpqagtllHFLRKEapdweqsigkvispelLHRTDLDPEVWDGSVGGELNLYGVKL 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1003 EtVRKTEAPD--PEVEALRAEVSKLEQqcqqqkqqveglthSLESERASRAEQDKALETLQGQLEEktQELGHSQAASAS 1080
Cdd:pfam12128  586 D-LKRIDVPEwaASEEELRERLDKAEE--------------ALQSAREKQAAAEEQLVQANGELEK--ASREETFARTAL 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1081 AQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERksslISSLEEEVSILNRQVLEKEGESKELKRlvVAESEKSQKLEE 1160
Cdd:pfam12128  649 KNARLDLRRLFDEKQSEKDKKNKALAERKDSANER----LNSLEAQLKQLDKKHQAWLEEQKEQKR--EARTEKQAYWQV 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1161 RLRLLQVETASSSARAAERSSALREEVQSLREE---------VEKQRVIS-ENLRQELTSQAERAEELGQELKAW----Q 1226
Cdd:pfam12128  723 VEGALDAQLALLKAAIAARRSGAKAELKALETWykrdlaslgVDPDVIAKlKREIRTLERKIERIAVRRQEVLRYfdwyQ 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1227 EKFFQKEQALsALQLEHTSTQalVSELlpakhlcQQLQAEQAAAEKRHREEIEQSKQAaggLRAELMRAQRELGELGPLR 1306
Cdd:pfam12128  803 ETWLQRRPRL-ATQLSNIERA--ISEL-------QQQLARLIADTKLRRAKLEMERKA---SEKQQVRLSENLRGLRCEM 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1307 QKVAEQERAA--QQLRAEKASYAEQLSMLKKAHGLLAEenrglgeranlgrqfleveldqAREKYVQELAAVRTD-AETH 1383
Cdd:pfam12128  870 SKLATLKEDAnsEQAQGSIGERLAQLEDLKLKRDYLSE----------------------SVKKYVEHFKNVIADhSGSG 927

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1384 LAEMRQEAQSTTRELevmtakyeGAK-VKVLEERQRFQEERQKLTAQVEELSKKLteYDQASkVQQQKLKAFQaqgGESQ 1462
Cdd:pfam12128  928 LAETWESLREEDHYQ--------NDKgIRLLDYRKLVPYLEQWFDVRVPQSIMVL--REQVS-ILGVDLTEFY---DVLA 993

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1463 QEVQRLQAQLNELQTQLSqkeqaaehyklqmekAKTHYDAKKQQNQELQDQLRDLEQLqkenKELR--AEAERLGRELQQ 1540
Cdd:pfam12128  994 DFDRRIASFSRELQREVG---------------EEAFFEGVSESAVRIRSKVSELEYW----PELRvfVKAFRLWKSDGF 1054

                          970       980       990
                   ....*....|....*....|....*....|.
gi 344240178  1541 AGLKTKEAEQACRHLSAQVRSLEAQVAHADQ 1571
Cdd:pfam12128 1055 GELPDEEYTQAMRRASDILPSAALSGGLNDL 1085
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
152-600 5.01e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 62.24  E-value: 5.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  152 LALLNEKQAASSQESRELEELRGKNESLTVRLHETLKQCQNLK-----TEKNQMDRKISQLSEENGDLSFKVREFASHLQ 226
Cdd:COG4913   290 LELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIrgnggDRLEQLEREIERLERELEERERRRARLEALLA 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  227 QL-------QGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERAS-----------QQ 288
Cdd:COG4913   370 ALglplpasAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSniparllalrdAL 449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  289 CESPAQEKGEV--LGDALQLETL-----------------------KQEAAKLAA-HNTQLQARIETLDCERSQQEAQL- 341
Cdd:COG4913   450 AEALGLDEAELpfVGELIEVRPEeerwrgaiervlggfaltllvppEHYAAALRWvNRLHLRGRLVYERVRTGLPDPERp 529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  342 ------LAERGHFEEEKQQ--LASLIADLQSSISNLSQakEELEQASQAqgaqLTAQVasLTALNTTLQQQQDQEL---- 409
Cdd:COG4913   530 rldpdsLAGKLDFKPHPFRawLEAELGRRFDYVCVDSP--EELRRHPRA----ITRAG--QVKGNGTRHEKDDRRRirsr 601

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  410 -------ASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSsslklKEQQLEEAAKDQEAARQDHAQQLAIVAEAREA 482
Cdd:COG4913   602 yvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQ-----ERREALQRLAEYSWDEIDVASAEREIAELEAE 676

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  483 sLRERDAARQQLETLEKEkaakLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAhqEQRQAQAHVT 562
Cdd:COG4913   677 -LERLDASSDDLAALEEQ----LEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAA--EDLARLELRA 749

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 344240178  563 ELEAQLKAEQQKVAEREKvmqeKAQLQEQLLALEETLQ 600
Cdd:COG4913   750 LLEERFAAALGDAVEREL----RENLEERIDALRARLN 783
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1042-1578 5.03e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.39  E-value: 5.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1042 SLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHskaeEEWKAQVARGQQEAERKSSLIS 1121
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKEL----EELKEEIEELEKELESLEGSKR 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1122 SLEEEVSILNRQVLEKEGESKELKRLV--VAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEkqrv 1199
Cdd:PRK03918  256 KLEEKIRELEERIEELKKEIEELEEKVkeLKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK---- 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1200 isenlrqELTSQAERAEELGQELKAWQEKffqkeqaLSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIE 1279
Cdd:PRK03918  332 -------ELEEKEERLEELKKKLKELEKR-------LEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELE 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1280 QSKQaagglraELMRAQREL-GELGPLRQKVAEQERAaqqlraekasyaeqLSMLKKAHG-------LLAEENRG-LGER 1350
Cdd:PRK03918  398 KAKE-------EIEEEISKItARIGELKKEIKELKKA--------------IEELKKAKGkcpvcgrELTEEHRKeLLEE 456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1351 ANLGRQFLEVELDQAREKyVQELAAVRTDAETHLAEMRQ-----EAQSTTRELEVMTAKYEgakvkvLEERQRFQEERQK 1425
Cdd:PRK03918  457 YTAELKRIEKELKEIEEK-ERKLRKELRELEKVLKKESEliklkELAEQLKELEEKLKKYN------LEELEKKAEEYEK 529

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1426 LTAQVEELSKKLTEYDQASKvqqqKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQK-----EQAAEHYKlQMEKAKTHY 1500
Cdd:PRK03918  530 LKEKLIKLKGEIKSLKKELE----KLEELKKKLAELEKKLDELEEELAELLKELEELgfesvEELEERLK-ELEPFYNEY 604

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1501 DAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQA-----GLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRD 1575
Cdd:PRK03918  605 LELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELrkeleELEKKYSEEEYEELREEYLELSRELAGLRAELEE 684


                  ...
gi 344240178 1576 LGK 1578
Cdd:PRK03918  685 LEK 687
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 391-599 8.53e-09

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 60.61  E-value: 8.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  391 VASLTALNTTLQQQQDQELASLKEQAKKEQAQmVQSLQEQEQAAQglrQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHA 470
Cdd:COG3883     7 AAPTPAFADPQIQAKQKELSELQAELEAAQAE-LDALQAELEELN---EEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  471 QQLAIVAEaREASLRERDAARQQLETLEKEK-----AAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHA 545
Cdd:COG3883    83 ERREELGE-RARALYRSGGSVSYLDVLLGSEsfsdfLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 344240178  546 CIEAAHQEQRQAQAHVTELEAQLKAEQqkvAEREKVMQEKAQLQEQLLALEETL 599
Cdd:COG3883   162 LKAELEAAKAELEAQQAEQEALLAQLS---AEEAAAEAQLAELEAELAAAEAAA 212
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1154-1612 8.68e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.52  E-value: 8.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1154 KSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERA--EELGQELKAWQEKFFQ 1231
Cdd:TIGR00618  195 KAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLkkQQLLKQLRARIEELRA 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1232 KEQALSALQLEHTSTQALVSELLPAKHLC-----QQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQ---------- 1296
Cdd:TIGR00618  275 QEAVLEETQERINRARKAAPLAAHIKAVTqieqqAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRrllqtlhsqe 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1297 ------------------RELGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL-GRQF 1357
Cdd:TIGR00618  355 ihirdahevatsireiscQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAkKQQE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1358 LEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTREL---EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELS 1434
Cdd:TIGR00618  435 LQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLqtkEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1435 KKLTEYD-------------QASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYD 1501
Cdd:TIGR00618  515 PARQDIDnpgpltrrmqrgeQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITV 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1502 AKK---QQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQ------------AGLKTKEAEQACRHLSAQVRSLEAQv 1566
Cdd:TIGR00618  595 RLQdltEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQcsqelalkltalHALQLTLTQERVREHALSIRVLPKE- 673

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 344240178  1567 aHADQQLRDLGKFQVATDALKSREPQKPQLDLSIDSLDLSLEEGTP 1612
Cdd:TIGR00618  674 -LLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDR 718
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
566-977 1.08e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  566 AQLKAEQQKVAEREKVMQEKAQLQEQLLALEEtlQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKAL 645
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEELEE--ELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  646 EQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARysamIQEQLAA 725
Cdd:COG4717   149 EELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEE----AQEELEE 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  726 LKGDHEKAGQEAQEEAVEvhgegQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMAstskvAACLKTL 805
Cdd:COG4717   225 LEEELEQLENELEAAALE-----ERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLA-----LLFLLLA 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  806 VLKAGEQQEMTSLELLKEPPGAGNKE-SNWLEEQRGGPFSSPQAALKAME--QEAEQMGSELERLRVALMKSQGQQQEER 882
Cdd:COG4717   295 REKASLGKEAEELQALPALEELEEEElEELLAALGLPPDLSPEELLELLDriEELQELLREAEELEEELQLEELEQEIAA 374

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  883 GQQEREVARLT--RERSQAQADLAQEKAAKAELEVRLQNTLNE-----QRVEFAALQEALDHALTEKEGKDQELAKLRGQ 955
Cdd:COG4717   375 LLAEAGVEDEEelRAALEQAEEYQELKEELEELEEQLEELLGEleellEALDEEELEEELEELEEELEELEEELEELREE 454

                         410       420
                  ....*....|....*....|....
gi 344240178  956 EAAQRTELKEL--QQTLEHLKTQL 977
Cdd:COG4717   455 LAELEAELEQLeeDGELAELLQEL 478
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 415-724 1.21e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 61.12  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  415 QAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEA----AKDQEAARQ----DHAQQ--------LAIVAE 478
Cdd:COG3096   289 ELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAAsdhlNLVQTALRQqekiERYQEdleelterLEEQEE 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  479 AREASLRERDAARQQLETLEKEkaakLESLQQQLEAANEARDSVQTSVTQVQQEKaelsQKIEELHACIEAAHQEQRQAQ 558
Cdd:COG3096   369 VVEEAAEQLAEAEARLEAAEEE----VDSLKSQLADYQQALDVQQTRAIQYQQAV----QALEKARALCGLPDLTPENAE 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  559 AHVTELEAQLKAEQQKVAE-REKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADAL----AEQQRCVTKMEAESRS 633
Cdd:COG3096   441 DYLAAFRAKEQQATEEVLElEQKLSVADAARRQFEKAYELVCKIAGEVERSQAWQTARELlrryRSQQALAQRLQQLRAQ 520

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  634 L--MEQREQEQKALE-----------QEKAGRKGLEARLQQLEeARQAETEALRRELAEATASQHRAESESEQLIREVES 700
Cdd:COG3096   521 LaeLEQRLRQQQNAErlleefcqrigQQLDAAEELEELLAELE-AQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAA 599

                         330       340
                  ....*....|....*....|....
gi 344240178  701 WQKRFEARQQEEARYSAMIQEQLA 724
Cdd:COG3096   600 RAPAWLAAQDALERLREQSGEALA 623
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1083-1587 1.45e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.85  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1083 RELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLE------------------------EEVSILNRQVLEKE 1138
Cdd:PRK03918  172 KEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISselpelreeleklekevkeleelkEEIEELEKELESLE 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1139 GESKELKRLVVAESEKSQKLEERLRLLQ-----VETASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAE 1213
Cdd:PRK03918  252 GSKRKLEEKIRELEERIEELKKEIEELEekvkeLKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1214 RAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQaagglraELM 1293
Cdd:PRK03918  332 ELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKE-------EIE 404

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1294 RAQREL-GELGPLRQKVAEQERAAQQLRAEK-------------------ASYAEQLSMLKKAHGLLAEENRGLGERANL 1353
Cdd:PRK03918  405 EEISKItARIGELKKEIKELKKAIEELKKAKgkcpvcgrelteehrkellEEYTAELKRIEKELKEIEEKERKLRKELRE 484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1354 GRQFLEVELDQAREKYV-QELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGaKVKVLEERqrfQEERQKLTAQVEE 1432
Cdd:PRK03918  485 LEKVLKKESELIKLKELaEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKG-EIKSLKKE---LEKLEELKKKLAE 560

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1433 LSKKLTEYDQASKVQQQKLKAFqaqGGESQQEVQRLQAQLNEL----------QTQLSQKEQAAEHYKLQMEKAKTHYDA 1502
Cdd:PRK03918  561 LEKKLDELEEELAELLKELEEL---GFESVEELEERLKELEPFyneylelkdaEKELEREEKELKKLEEELDKAFEELAE 637

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1503 KKQQNQELQDQLRDLEQL--QKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQ 1580
Cdd:PRK03918  638 TEKRLEELRKELEELEKKysEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLE 717


                  ....*..
gi 344240178 1581 VATDALK 1587
Cdd:PRK03918  718 KALERVE 724
mukB PRK04863
chromosome partition protein MukB;
1341-1574 1.59e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 60.74  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1341 AEENRGLGERANLGRQflevELDQAREKyvqelaavRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAK---VKVLEERq 1417
Cdd:PRK04863  278 ANERRVHLEEALELRR----ELYTSRRQ--------LAAEQYRLVEMARELAELNEAESDLEQDYQAASdhlNLVQTAL- 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1418 RFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQL-------NELQTQLSQKEQAAEHYK 1490
Cdd:PRK04863  345 RQQEKIERYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLadyqqalDVQQTRAIQYQQAVQALE 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1491 ----------LQMEKAKTHYDAKKQQNQELQDQLRDLEQ---LQKENKELRAEAERLGREL------QQAGLKTKEAEQA 1551
Cdd:PRK04863  425 rakqlcglpdLTADNAEDWLEEFQAKEQEATEELLSLEQklsVAQAAHSQFEQAYQLVRKIagevsrSEAWDVARELLRR 504

                         250       260
                  ....*....|....*....|....*.
gi 344240178 1552 C---RHLSAQVRSLEAQVAHADQQLR 1574
Cdd:PRK04863  505 LreqRHLAEQLQQLRMRLSELEQRLR 530
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 397-723 1.77e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 59.91  E-value: 1.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   397 LNTTLQQQQD--QELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKL---KEQQLEEAAKDQEAARQDHAQ 471
Cdd:pfam07888   36 LEECLQERAEllQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQsreKHEELEEKYKELSASSEELSE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   472 QLAIVAEAREAS---LRERDAARQQLETLEKEKAAKLESLQQQLEAA-------NEARDSVQTSVTQVQQEKAELSQKIE 541
Cdd:pfam07888  116 EKDALLAQRAAHearIRELEEDIKTLTQRVLERETELERMKERAKKAgaqrkeeEAERKQLQAKLQQTEEELRSLSKEFQ 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   542 ELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQ 621
Cdd:pfam07888  196 ELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELH 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   622 RCVTKMEAESRSLME--------------QREQEQKALEQEKAGRKGLEARLQQLEEARQAET---EALRRELAEATASQ 684
Cdd:pfam07888  276 QARLQAAQLTLQLADaslalregrarwaqERETLQQSAEADKDRIEKLSAELQRLEERLQEERmerEKLEVELGREKDCN 355

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 344240178   685 HRAESESEQLIREVESWQKrfeARQQEEARYSAMIQEQL 723
Cdd:pfam07888  356 RVQLSESRRELQELKASLR---VAQKEKEQLQAEKQELL 391
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
928-1528 1.82e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 60.70  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  928 FAALQEALDHaLTEKEGKDQELAKLRgQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEeasapeaqletvRK 1007
Cdd:COG4913   224 FEAADALVEH-FDDLERAHEALEDAR-EQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQ------------RR 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1008 TEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQD-KALETLQGQLEEKTQELGHSQAASASAQRELT 1086
Cdd:COG4913   290 LELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLA 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1087 ALHAKAQDHskaEEEWKAQVARGQQEAERKSSLISSLEEEV-------SILNRQVLEKEGESKELKRLVVAESEKSQKLE 1159
Cdd:COG4913   370 ALGLPLPAS---AEEFAALRAEAAALLEALEEELEALEEALaeaeaalRDLRRELRELEAEIASLERRKSNIPARLLALR 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1160 ERLR---------------LLQVETASSSAR-AAER----------------SSALR-------------EEVQSLREEV 1194
Cdd:COG4913   447 DALAealgldeaelpfvgeLIEVRPEEERWRgAIERvlggfaltllvppehyAAALRwvnrlhlrgrlvyERVRTGLPDP 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1195 EKQRV----------ISEN-----LRQELTSQA-----ERAEELGQELKA-------------------------W---- 1225
Cdd:COG4913   527 ERPRLdpdslagkldFKPHpfrawLEAELGRRFdyvcvDSPEELRRHPRAitragqvkgngtrhekddrrrirsrYvlgf 606

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1226 --QEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEqskqaAGGLRAELMRAQREL---- 1299
Cdd:COG4913   607 dnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEID-----VASAEREIAELEAELerld 681

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1300 ---GELGPLRQKVAEQERAAQQLRAEKASyaeqlsmLKKAHGLLAEEnrglgeranlgRQFLEVELDQAREKYVQELAAV 1376
Cdd:COG4913   682 assDDLAALEEQLEELEAELEELEEELDE-------LKGEIGRLEKE-----------LEQAEEELDELQDRLEAAEDLA 743

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1377 RTDAETHLAEMRQEAQSTTRELEVmtakyegakvkvleeRQRFQEERQKLTAQVEELSKKLTEYDQASKvqqQKLKAFQA 1456
Cdd:COG4913   744 RLELRALLEERFAAALGDAVEREL---------------RENLEERIDALRARLNRAEEELERAMRAFN---REWPAETA 805

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178 1457 QGGESQQEVQRLQAQLNELQTQ-LSQKEQAAEHYKL-QMEKAKTHYDAK-KQQNQELQDQLRDLeqlqkeNKELR 1528
Cdd:COG4913   806 DLDADLESLPEYLALLDRLEEDgLPEYEERFKELLNeNSIEFVADLLSKlRRAIREIKERIDPL------NDSLK 874
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 382-676 2.02e-08

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 60.04  E-value: 2.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   382 AQGAQLTAQVASLTALNTTLQQQQDQELASLKEQA---------------KKEQAQMVQSLQEQEQAAQGLRQQVEQLSS 446
Cdd:pfam05667  196 AQPSSRASVVPSLLERNAAELAAAQEWEEEWNSQGlasrltpeeyrkrkrTKLLKRIAEQLRSAALAGTEATSGASRSAQ 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   447 SLKLKEQQLEEAAKDQ----EAARQDHAQQLAiVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEaaneardsv 522
Cdd:pfam05667  276 DLAELLSSFSGSSTTDtgltKGSRFTHTEKLQ-FTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLE--------- 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   523 qtsvtqvqqekaELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQIT 602
Cdd:pfam05667  346 ------------DLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDLLPDAEENIAKLQALVDAS 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   603 KGSLEE-----EKHRTAD-----ALAEQQrcvTKMEAESRSLMEQ----REQEQKAleQEKAGRKglEARLQQLeearQA 668
Cdd:pfam05667  414 AQRLVElagqwEKHRVPLieeyrALKEAK---SNKEDESQRKLEEikelREKIKEV--AEEAKQK--EELYKQL----VA 482


                   ....*...
gi 344240178   669 ETEALRRE 676
Cdd:pfam05667  483 EYERLPKD 490
mukB PRK04863
chromosome partition protein MukB;
1169-1566 2.04e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 60.36  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1169 TASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKA-------------WQEKFFQKEQA 1235
Cdd:PRK04863  277 HANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAasdhlnlvqtalrQQEKIERYQAD 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1236 LSAL--QLEHtstQALVSELlpakhlcqqlqaeQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELgplrQKVAEQE 1313
Cdd:PRK04863  357 LEELeeRLEE---QNEVVEE-------------ADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQ----QTRAIQY 416

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1314 RAAQQL--RAEKASYAEQLSmLKKAHGLLAE---ENRGLGERANLGRQFLEVElDQAREKYVQELAAVRTDA-ETHLAEM 1387
Cdd:PRK04863  417 QQAVQAleRAKQLCGLPDLT-ADNAEDWLEEfqaKEQEATEELLSLEQKLSVA-QAAHSQFEQAYQLVRKIAgEVSRSEA 494

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1388 RQEAQSTTRELEvmTAKYEGAKVKVLEERQRFQEERQKLTAQVEELskkLTEYDQASKVQQQKLKAFQAQGGESQQEVQR 1467
Cdd:PRK04863  495 WDVARELLRRLR--EQRHLAEQLQQLRMRLSELEQRLRQQQRAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLES 569

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1468 LQAQLNELQTQLSQKEQAAEHYKLQMEKakthYDAKKQQNQELQDQlrdLEQLQKENKELRAEAERLGRELQQAGLKTKE 1547
Cdd:PRK04863  570 LSESVSEARERRMALRQQLEQLQARIQR----LAARAPAWLAAQDA---LARLREQSGEEFEDSQDVTEYMQQLLERERE 642

                         410
                  ....*....|....*....
gi 344240178 1548 AEQACRHLSAQVRSLEAQV 1566
Cdd:PRK04863  643 LTVERDELAARKQALDEEI 661
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 2654-2794 3.05e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 59.51  E-value: 3.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2654 TSMLSFTRlayilpAHESLGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLnniYVPYQE--TEKLGNFN-------ET 2723
Cdd:cd21882   420 CNVLYYTR------GFQMLGIYTVMIQKMIlRDLMRFCWVYLVFLFGFASAF---VILFQTedPNKLGEFRdypdallEL 490

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178 2724 FQFlFWTMFGMEEHTVVDMPqflvpeFVGRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFAR 2794
Cdd:cd21882   491 FKF-TIGMGDLPFNENVDFP------FVYLILLLAYVILTYLLLLNMLIALMGETVNRVAQESDEIWKLQK 554
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 219-1192 3.64e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 59.68  E-value: 3.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   219 REFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCEspaqekge 298
Cdd:TIGR00606  137 REMISHLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVQEHQME-------- 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   299 vlgdalqLETLKQEAAKLAAHNTQLQARIETLDCERS-----QQEAQLLAERghfEEEKQQLASLIADLQSSISNLSQAK 373
Cdd:TIGR00606  209 -------LKYLKQYKEKACEIRDQITSKEAQLESSREivksyENELDPLKNR---LKEIEHNLSKIMKLDNEIKALKSRK 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   374 EELEQASQaqgaqltaqvaSLTALNTTLQQQQDQELASLKE-------QAKKEQAQMVQSLQEQEQAAQGLRQQVEQL-- 444
Cdd:TIGR00606  279 KQMEKDNS-----------ELELKMEKVFQGTDEQLNDLYHnhqrtvrEKERELVDCQRELEKLNKERRLLNQEKTELlv 347

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   445 -SSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREA-SLRERDAA----RQQLETLEKEKAAKLESLQQQL----EA 514
Cdd:TIGR00606  348 eQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPfSERQIKNFhtlvIERQEDEAKTAAQLCADLQSKErlkqEQ 427

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   515 ANEARDSVQTSVTQVQQEKAELSQKIEELHACIeaahQEQRQAQAHVTELeaqLKAEQQ-KVAEREKVMQEKAQLQEQLL 593
Cdd:TIGR00606  428 ADEIRDEKKGLGRTIELKKEILEKKQEELKFVI----KELQQLEGSSDRI---LELDQElRKAERELSKAEKNSLTETLK 500

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   594 ALEETLQITKGSLEEEKHRTADALAEQQR---CVTKMEAESRSLMEQREQEQKALEQ---EKAGRKGLEARLQQLEE--- 664
Cdd:TIGR00606  501 KEVKSLQNEKADLDRKLRKLDQEMEQLNHhttTRTQMEMLTKDKMDKDEQIRKIKSRhsdELTSLLGYFPNKKQLEDwlh 580

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   665 ARQAETEALRRELAEATASQHRAESESEQLIREVESwqkrfeaRQQEEARYSAMIqeqlaalkgdHEKAGQEAQEEAVEV 744
Cdd:TIGR00606  581 SKSKEINQTRDRLAKLNKELASLEQNKNHINNELES-------KEEQLSSYEDKL----------FDVCGSQDEESDLER 643

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   745 HGEgQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKep 824
Cdd:TIGR00606  644 LKE-EIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKK-- 720

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   825 pgagnkesnwLEEQRggpfsspqaalKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLA 904
Cdd:TIGR00606  721 ----------KEKRR-----------DEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMP 779

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   905 QEKAAKAEL-------EVRLQNTLNEQRVE-FAALQEALDHALT------EKEGKDQELAKLRGQEAAQRTELKELQQTL 970
Cdd:TIGR00606  780 EEESAKVCLtdvtimeRFQMELKDVERKIAqQAAKLQGSDLDRTvqqvnqEKQEKQHELDTVVSKIELNRKLIQDQQEQI 859

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   971 EHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERasr 1050
Cdd:TIGR00606  860 QHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSN--- 936

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1051 aeqDKALETLQGQLEEKTQELGHSQAASASAQ-----------RELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSL 1119
Cdd:TIGR00606  937 ---KKAQDKVNDIKEKVKNIHGYMKDIENKIQdgkddylkqkeTELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQ 1013

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1120 ISSLEEEVSILNRQVLEKEGES------KELKRLVVAESEKS-QKLEERLRLLQVETASSSARAAERSSALREEVQSLRE 1192
Cdd:TIGR00606 1014 ERWLQDNLTLRKRENELKEVEEelkqhlKEMGQMQVLQMKQEhQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELRE 1093
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
766-1298 4.72e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.16  E-value: 4.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  766 RALQQVKEKEVRAQKLADDLTTLQekmastskvaACLKTLVLKAGEQQemtsLELLKEPPGAGNKESNWLEEQRggpfss 845
Cdd:COG4913   252 ELLEPIRELAERYAAARERLAELE----------YLRAALRLWFAQRR----LELLEAELEELRAELARLEAEL------ 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  846 pqAALKAMEQEAEQmgsELERLRVALMKSQGQQqeergqqereVARLTRERSQAQADLAQEKAAKAELEVRLQN---TLN 922
Cdd:COG4913   312 --ERLEARLDALRE---ELDELEAQIRGNGGDR----------LEQLEREIERLERELEERERRRARLEALLAAlglPLP 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  923 EQRVEFAALQEALDHALT----EKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAP 998
Cdd:COG4913   377 ASAEEFAALRAEAAALLEaleeELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLD 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  999 EAQLE------TVRKTEAP------------------DPEVEALRAEVskLEQQCQQQKQQVEGLTHSLESERASRAEQD 1054
Cdd:COG4913   457 EAELPfvgeliEVRPEEERwrgaiervlggfaltllvPPEHYAAALRW--VNRLHLRGRLVYERVRTGLPDPERPRLDPD 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1055 -----------KALETLQGQLE--------EKTQEL-GHSQAASASAQ-RELTALHAKaQDHSKAEEEW------KAQVA 1107
Cdd:COG4913   535 slagkldfkphPFRAWLEAELGrrfdyvcvDSPEELrRHPRAITRAGQvKGNGTRHEK-DDRRRIRSRYvlgfdnRAKLA 613

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1108 RGQQEAERksslissLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARaAERSSALRE-- 1185
Cdd:COG4913   614 ALEAELAE-------LEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELE-AELERLDASsd 685

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1186 EVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEkffQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQA 1265
Cdd:COG4913   686 DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEE---ELDELQDRLEAAEDLARLELRALLEERFAAALGDA 762

                         570       580       590
                  ....*....|....*....|....*....|...
gi 344240178 1266 EQAAAEKRHREEIEQSKQAAGGLRAELMRAQRE 1298
Cdd:COG4913   763 VERELRENLEERIDALRARLNRAEEELERAMRA 795
PRK11637 PRK11637
AmiB activator; Provisional
 409-675 4.99e-08

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 58.17  E-value: 4.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  409 LASLKEQAKKEQAQMvQSLQ----EQEQAAQGLRQQVEQLSSSLKLKEQQLeeaakdQEAARQDHAQQLAIVAEAREASL 484
Cdd:PRK11637   35 LCAFSAHASDNRDQL-KSIQqdiaAKEKSVRQQQQQRASLLAQLKKQEEAI------SQASRKLRETQNTLNQLNKQIDE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  485 RERDAARqqletLEKEKAAKLESLQQQLEAA-------------------------------NEARdsvQTSVTQVQQEK 533
Cdd:PRK11637  108 LNASIAK-----LEQQQAAQERLLAAQLDAAfrqgehtglqlilsgeesqrgerilayfgylNQAR---QETIAELKQTR 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  534 AELSQkieelhaciEAAHQEQRQAQahvtelEAQLKAEQQkvAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKH-- 611
Cdd:PRK11637  180 EELAA---------QKAELEEKQSQ------QKTLLYEQQ--AQQQKLEQARNERKKTLTGLESSLQKDQQQLSELRAne 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  612 -RTADALAEQQRcvtkmEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRR 675
Cdd:PRK11637  243 sRLRDSIARAER-----EAKARAEREAREAARVRDKQKQAKRKGSTYKPTESERSLMSRTGGLGR 302
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1416-1576 5.10e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 58.63  E-value: 5.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1416 RQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKlkafqaqggesQQEVQRLQAQLNELQTQLSQKEQAAEHYKL--QM 1493
Cdd:COG4717    66 PELNLKELKELEEELKEAEEKEEEYAELQEELEEL-----------EEELEELEAELEELREELEKLEKLLQLLPLyqEL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1494 EKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTK-EAEQACRHLSAQVRSLEAQVAHADQQ 1572
Cdd:COG4717   135 EALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSlATEEELQDLAEELEELQQRLAELEEE 214


                  ....
gi 344240178 1573 LRDL 1576
Cdd:COG4717   215 LEEA 218
PRK11281 PRK11281
mechanosensitive channel MscK;
360-728 5.27e-08

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 59.15  E-value: 5.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  360 ADLQSSISNLsqAKEELEQASQAqgaqltaqvASLTALNTTLQ-----QQQDQELASLKEQAkkeqaqmvqslqeqEQAA 434
Cdd:PRK11281   39 ADVQAQLDAL--NKQKLLEAEDK---------LVQQDLEQTLAlldkiDRQKEETEQLKQQL--------------AQAP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  435 QGLRQQVEQLSsslKLKEQqleeaakDQEAARQDHAQQlaivaeareaSLRerdaarqQLETLEKEKAAKLESLQQQLEA 514
Cdd:PRK11281   94 AKLRQAQAELE---ALKDD-------NDEETRETLSTL----------SLR-------QLESRLAQTLDQLQNAQNDLAE 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  515 ANEARDSVQTSVTQVQQEKAELSQKIeelhacieaahQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQE-KAQLQEQLL 593
Cdd:PRK11281  147 YNSQLVSLQTQPERAQAALYANSQRL-----------QQIRNLLKGGKVGGKALRPSQRVLLQAEQALLNaQNDLQRKSL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  594 ALEETLQitkgSLEEEKHrtaDALAEQQRCVTKMEAE------SRSLMEQREQEQKALEQEKAGRKGLEARLQQ-LEEAR 666
Cdd:PRK11281  216 EGNTQLQ----DLLQKQR---DYLTARIQRLEHQLQLlqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQeLEINL 288

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  667 QaeteaLRRELAEATAsqhRAESESEQLIReVESWQKRfeARQQEEArysamIQEQLAALKG 728
Cdd:PRK11281  289 Q-----LSQRLLKATE---KLNTLTQQNLR-VKNWLDR--LTQSERN-----IKEQISVLKG 334
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 577-1439 5.45e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.96  E-value: 5.45e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   577 EREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESrslmeqreQEQKALEQEKAGRKGLE 656
Cdd:pfam05483   86 EAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEI--------QENKDLIKENNATRHLC 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   657 ARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKrfearQQEEARYsamiqEQLAALKGDHEKAGQE 736
Cdd:pfam05483  158 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV-----QAENARL-----EMHFKLKEDHEKIQHL 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   737 AQEEAVEVHGEgqigEQQSPLAqlhttlaraLQQVKEKEVRAQkladDLTTLQEKMAStskvaaclktlvlKAGEQQEMT 816
Cdd:pfam05483  228 EEEYKKEINDK----EKQVSLL---------LIQITEKENKMK----DLTFLLEESRD-------------KANQLEEKT 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   817 SLEllkeppgagnkesnwleeqrggpfsspQAALKAMEQEAEQMGSELERLRVALMKSQGQQQEERGQ---QEREVARLT 893
Cdd:pfam05483  278 KLQ---------------------------DENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDlqiATKTICQLT 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   894 RERSQAQADLAQEKAAKAELEVRLQNTL---------NEQRVEfaALQEALDHALTEKEGKDQELAKLRGQEAAQRTELK 964
Cdd:pfam05483  331 EEKEAQMEELNKAKAAHSFVVTEFEATTcsleellrtEQQRLE--KNEDQLKIITMELQKKSSELEEMTKFKNNKEVELE 408

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   965 ELQQTLEHLKTQLVKKEKEQHPAGSTGGEEAsapeaqlETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLE 1044
Cdd:pfam05483  409 ELKKILAEDEKLLDEKKQFEKIAEELKGKEQ-------ELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELE 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1045 SERASRAEQDKALETLQGQLEEKTQElghsqaasasaqreltalhakAQDHSKAEEEWKAQVARGQQEAERKSSLISSLE 1124
Cdd:pfam05483  482 KEKLKNIELTAHCDKLLLENKELTQE---------------------ASDMTLELKKHQEDIINCKKQEERMLKQIENLE 540

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1125 EEVSILNRqvlEKEGESKELKRLVVAESEKSQKLEERLRLLQVETAsssaRAAERSSALREEVQSLREEVEKQRVISENL 1204
Cdd:pfam05483  541 EKEMNLRD---ELESVREEFIQKGDEVKCKLDKSEENARSIEYEVL----KKEKQMKILENKCNNLKKQIENKNKNIEEL 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1205 RQELTSQAERAEELGQELKAWQEKffqkeqaLSALQLEHTSTQALVSELLpakhlcqqlqaeqaaaeKRHREEIEQSKQA 1284
Cdd:pfam05483  614 HQENKALKKKGSAENKQLNAYEIK-------VNKLELELASAKQKFEEII-----------------DNYQKEIEDKKIS 669

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1285 AGGLRAELMRAQRELGELGPLRQKVaeqERAAQQLRAEKASYAEQLsmlKKAHGLLAEENRGlgeranlgrqflEVELDQ 1364
Cdd:pfam05483  670 EEKLLEEVEKAKAIADEAVKLQKEI---DKRCQHKIAEMVALMEKH---KHQYDKIIEERDS------------ELGLYK 731

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  1365 AREkyvQELAAVRTDAETHLAEMRQEAQSTTRELEVMtakyegakvkvleerqrfQEERQKLTAQVEELSKKLTE 1439
Cdd:pfam05483  732 NKE---QEQSSAKAALEIELSNIKAELLSLKKQLEIE------------------KEEKEKLKMEAKENTAILKD 785
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 372-805 6.05e-08

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 58.66  E-value: 6.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  372 AKEELEQ-ASQAQG------AQLTAQVASLTALN------TTLQQQQDQELASL--KEQAKKEQAQMVQSLQEQEQA--- 433
Cdd:PRK10246  196 ARTELEKlQAQASGvalltpEQVQSLTASLQVLTdeekqlLTAQQQQQQSLNWLtrLDELQQEASRRQQALQQALAAeek 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  434 -------------AQGLR---QQVEQLSSSLKLKEQQLEEA-AKDQEAARQDhaqqlaivAEAREASLRERDAARQQLET 496
Cdd:PRK10246  276 aqpqlaalslaqpARQLRphwERIQEQSAALAHTRQQIEEVnTRLQSTMALR--------ARIRHHAAKQSAELQAQQQS 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  497 LEKEKAA--KLESLQQQLEA-----ANEARDSVQtsVTQVQQEKAELSQKIEELH-----------ACIEAAHQEQRQAQ 558
Cdd:PRK10246  348 LNTWLAEhdRFRQWNNELAGwraqfSQQTSDREQ--LRQWQQQLTHAEQKLNALPaitltltadevAAALAQHAEQRPLR 425

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  559 AHVTELEAQLKAEQQKVAEREKVMQekaQLQEQLLALEETLQITKGSLEEEKHRTADAlaeqqRCVTKMEAESRSLMEQR 638
Cdd:PRK10246  426 QRLVALHGQIVPQQKRLAQLQVAIQ---NVTQEQTQRNAALNEMRQRYKEKTQQLADV-----KTICEQEARIKDLEAQR 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  639 EQ-------------EQKALEQEKAGRKGL-EARLQQLE---EARQAETEALRRELAEATASQHRAESESEQLIRE---- 697
Cdd:PRK10246  498 AQlqagqpcplcgstSHPAVEAYQALEPGVnQSRLDALEkevKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQEeqal 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  698 VESWQKRFEARQ-------------QEEARYsamiQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTL 764
Cdd:PRK10246  578 TQQWQAVCASLNitlqpqddiqpwlDAQEEH----ERQLRLLSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGY 653

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  765 ARALQQVKEKEV----------RAQKLADDLTTLQEKMAstsKVAACLKTL 805
Cdd:PRK10246  654 ALTLPQEDEEASwlatrqqeaqSWQQRQNELTALQNRIQ---QLTPLLETL 701
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
417-714 6.54e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 58.49  E-value: 6.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  417 KKEQAQMVQSLQEQEQAAQGLRQQVEQLSS---------SLKLKEQQLEEAAKDQEAARQ-------------------- 467
Cdd:COG3206    63 PQSSDVLLSGLSSLSASDSPLETQIEILKSrpvlervvdKLNLDEDPLGEEASREAAIERlrknltvepvkgsnvieisy 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  468 --DHAQQLAIVAEA------REASLRERDAARQQLETLEKEkaakLESLQQQLEAANEARDS--VQTSVTQVQQEKAELS 537
Cdd:COG3206   143 tsPDPELAAAVANAlaeaylEQNLELRREEARKALEFLEEQ----LPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  538 QKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVmQEKAQLQEQLLALEETLQITKGSLEEEkHRTADAL 617
Cdd:COG3206   219 QQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQS-PVIQQLRAQLAELEAELAELSARYTPN-HPDVIAL 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  618 AEQQrcvtkmeAESRSLMEQREQeqKALEQEKAGRKGLEARLQQLeearQAETEALRRELAEATasqhRAESESEQLIRE 697
Cdd:COG3206   297 RAQI-------AALRAQLQQEAQ--RILASLEAELEALQAREASL----QAQLAQLEARLAELP----ELEAELRRLERE 359

                         330
                  ....*....|....*....
gi 344240178  698 VESWQKRFEA--RQQEEAR 714
Cdd:COG3206   360 VEVARELYESllQRLEEAR 378
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 402-697 6.62e-08

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 57.24  E-value: 6.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   402 QQQQDQELASLKEQAKKEQAQMVQSLQEQ--EQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEA 479
Cdd:pfam13868   53 RERALEEEEEKEEERKEERKRYRQELEEQieEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEI 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   480 REA-----SLRERDAARQQLETLE-----KEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEA 549
Cdd:pfam13868  133 DEFneeqaEWKELEKEEEREEDERileylKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQ 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   550 AHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEetlqitkgslEEEKHRTADALAEQQRcvtkmea 629
Cdd:pfam13868  213 EEQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAERE----------EEEFERMLRKQAEDEE------- 275

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178   630 esRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIRE 697
Cdd:pfam13868  276 --IEQEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEEAERRERIEEERQKKLKE 341
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 362-642 6.68e-08

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 58.53  E-value: 6.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  362 LQSSISNLSQAKEELEQASQAQGAQLTAQVASL-TALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQ---------- 430
Cdd:PRK10929   18 YAATAPDEKQITQELEQAKAAKTPAQAEIVEALqSALNWLEERKGSLERAKQYQQVIDNFPKLSAELRQQlnnerdeprs 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  431 ---EQAAQGLRQQVEQLSSSLKLKEQQLEEaakDQEAARQ--DHAQQL-AIVAEAReaslRERDAARQQLETLEKEKAAK 504
Cdd:PRK10929   98 vppNMSTDALEQEILQVSSQLLEKSRQAQQ---EQDRAREisDSLSQLpQQQTEAR----RQLNEIERRLQTLGTPNTPL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  505 LESLQQQLEAANEARDSvqtsvtQVQQ-EKAELS----QKIEELHAciEAAHQEQRQAQAHVTELEAQLKAEQQKVAER- 578
Cdd:PRK10929  171 AQAQLTALQAESAALKA------LVDElELAQLSannrQELARLRS--ELAKKRSQQLDAYLQALRNQLNSQRQREAERa 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  579 ----EKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTaDALAEQQRCVTKMEAESR-SLMEQREQEQ 642
Cdd:PRK10929  243 lestELLAEQSGDLPKSIVAQFKINRELSQALNQQAQRM-DLIASQQRQAASQTLQVRqALNTLREQSQ 310
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1411-1589 6.75e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 6.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1411 KVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQ-----KEQA 1485
Cdd:COG4942    31 QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAqkeelAELL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1486 AEHYKL----------------QMEKAKTHYDAKKQQNQELQDQLR-DLEQLQKENKELRAEAERLGRELQQAGLKTKEA 1548
Cdd:COG4942   111 RALYRLgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELRaDLAELAALRAELEAERAELEALLAELEEERAAL 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 344240178 1549 EQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSR 1589
Cdd:COG4942   191 EALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1301-1526 7.06e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 7.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1301 ELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEvELDQAREKYVQELAAVRTDA 1380
Cdd:COG4942    28 ELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA-ELEKEIAELRAELEAQKEEL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1381 ETHLAEMrQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGE 1460
Cdd:COG4942   107 AELLRAL-YRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEE 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178 1461 SQQEVQRLQAQLNELQTQLSQKEQAAEhyklqmekakTHYDAKKQQNQELQDQLRDLEQLQKENKE 1526
Cdd:COG4942   186 ERAALEALKAERQKLLARLEKELAELA----------AELAELQQEAEELEALIARLEAEAAAAAE 241
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 427-599 7.21e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 56.09  E-value: 7.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  427 LQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDhaqqlaivaeareasLRERDAARQQLETLEKEKAAKLE 506
Cdd:COG1579    12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---------------LEDLEKEIKRLELEIEEVEARIK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  507 SLQQQLEAANEARD--SVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKV-AEREKVMQ 583
Cdd:COG1579    77 KYEEQLGNVRNNKEyeALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELdEELAELEA 156

                         170
                  ....*....|....*.
gi 344240178  584 EKAQLQEQLLALEETL 599
Cdd:COG1579   157 ELEELEAEREELAAKI 172
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 245-699 9.06e-08

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 57.78  E-value: 9.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   245 EWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQceSPAQEKgeVLGDALQLETLKQEAAKLAAHNTQLQ 324
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQERLDQLESGDDSG--TPGGKK--YLLLQKQLEQLQEENFRLETARDDYR 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   325 ARIETLDCErsqqeaqlLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELeqasqaqgAQLTAQVASLtalnttlqQQ 404
Cdd:pfam05622   87 IKCEELEKE--------VLELQHRNEELTSLAEEAQALKDEMDILRESSDKV--------KKLEATVETY--------KK 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   405 QDQELASLKEQAK------KEQAQMVQSLQEQEQAAQGLRQQVEqlssslkLKEQQLEEAAK--DQEAARQDHAQ----- 471
Cdd:pfam05622  143 KLEDLGDLRRQVKlleernAEYMQRTLQLEEELKKANALRGQLE-------TYKRQVQELHGklSEESKKADKLEfeykk 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   472 ---QLAIVAEAREASLRERDAARQQLETL--------------------------------------------------- 497
Cdd:pfam05622  216 leeKLEALQKEKERLIIERDTLRETNEELrcaqlqqaelsqadallspssdpgdnlaaeimpaeireklirlqhenkmlr 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   498 ---EKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELhacieaahQEQRQAQAHVTELEAQLKaeQQK 574
Cdd:pfam05622  296 lgqEGSYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEEL--------QKALQEQGSKAEDSSLLK--QKL 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   575 VAEREKVMQEKAQLQEQLLALEETLQitkgSLEEEKHRTADALaeqQRCVTKMEAESRSlMEQReqEQKALEQEKAGRKG 654
Cdd:pfam05622  366 EEHLEKLHEAQSELQKKKEQIEELEP----KQDSNLAQKIDEL---QEALRKKDEDMKA-MEER--YKKYVEKAKSVIKT 435

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 344240178   655 LEARLQQleeARQAETEALRRELAEATASQHRAESESEQ--LIREVE 699
Cdd:pfam05622  436 LDPKQNP---ASPPEIQALKNQLLEKDKKIEHLERDFEKskLQREQE 479
HkD_NuMA cd22224
Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also ...
 1-44 9.24e-08

Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins; NuMA, also called nuclear mitotic apparatus protein 1, or nuclear matrix protein-22 (NMP-22), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles, and the alignment and segregation of chromosomes during mitotic cell division. The model corresponds to the N-terminal conserved globular Hook domain of NuMA, which folds as a variant of the helical calponin homology (CH) domain. It directly binds dynein light intermediate chains LIC1 and LIC2 through a conserved hydrophobic patch shared among other Hook adaptors.


Pssm-ID: 411795  Cd Length: 148  Bit Score: 53.73  E-value: 9.24e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 344240178    1 MSSRNPrdWEQFEYRIQAELAVILKFMLDHEDSLNLIEDLENFL 44
Cdd:cd22224   106 MNNNLT--LEKLDYKTELELASILRFVLDNEDGLYLSEGLDKFL 147
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
311-608 9.42e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 58.10  E-value: 9.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  311 QEAAKLAAHNTQLQARIETLdceRSQQEAQLLAER----GHFEEEKQQLASLIADLQSSISnLSQAKE------ELEQAS 380
Cdd:COG3206    71 SGLSSLSASDSPLETQIEIL---KSRPVLERVVDKlnldEDPLGEEASREAAIERLRKNLT-VEPVKGsnvieiSYTSPD 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  381 QAQGAQLTAQVAS--LTALNTTLQQQQDQELASLKEQAKKEQAQmvqsLQEQEQAAQGLRQQ--VEQLSSSLKLKEQQLE 456
Cdd:COG3206   147 PELAAAVANALAEayLEQNLELRREEARKALEFLEEQLPELRKE----LEEAEAALEEFRQKngLVDLSEEAKLLLQQLS 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  457 EAAKDQEAARQDHAQQLAIVAEAREASLRERDAA------------RQQLETLEkekaAKLESLQQQLEAANEArdsvqt 524
Cdd:COG3206   223 ELESQLAEARAELAEAEARLAALRAQLGSGPDALpellqspviqqlRAQLAELE----AELAELSARYTPNHPD------ 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  525 sVTQVQQEKAELSQKI-EELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITK 603
Cdd:COG3206   293 -VIALRAQIAALRAQLqQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLL 371


                  ....*
gi 344240178  604 GSLEE 608
Cdd:COG3206   372 QRLEE 376
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 484-648 1.06e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 55.32  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  484 LRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQ------RQA 557
Cdd:COG1579    12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnvrnnKEY 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  558 QAHVTELEAqLKAEQQKVAEREK-VMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEqqrcvtkMEAESRSLME 636
Cdd:COG1579    92 EALQKEIES-LKRRISDLEDEILeLMERIEELEEELAELEAELAELEAELEEKKAELDEELAE-------LEAELEELEA 163

                         170
                  ....*....|..
gi 344240178  637 QREQEQKALEQE 648
Cdd:COG1579   164 EREELAAKIPPE 175
Caldesmon pfam02029
Caldesmon;
894-1210 1.24e-07

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 57.18  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   894 RERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAAL------QEALD--HALTEKEGKDQELAKLRGQEAAQRTELKE 965
Cdd:pfam02029   11 RRRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSelkpsgQGGLDeeEAFLDRTAKREERRQKRLQEALERQKEFD 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   966 LQQTLEHLKTQLVKKEKEQHPAGS------TGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGL 1039
Cdd:pfam02029   91 PTIADEKESVAERKENNEEEENSSwekeekRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVP 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1040 THSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHS-------KAEEEWKAQVARGQQE 1112
Cdd:pfam02029  171 TENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQgglsqsqEREEEAEVFLEAEQKL 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1113 AERKSSLISSLEEEVSILNRQVLEKEGESKELKRlvvaeseksqKLEERLRLLQVETASSSARAAERSSALREEVQSLRE 1192
Cdd:pfam02029  251 EELRRRRQEKESEEFEKLRQKQQEAELELEELKK----------KREERRKLLEEEEQRRKQEEAERKLREEEEKRRMKE 320

                          330
                   ....*....|....*...
gi 344240178  1193 EVEKQRVISENLRQELTS 1210
Cdd:pfam02029  321 EIERRRAEAAEKRQKLPE 338
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 354-974 1.43e-07

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 57.45  E-value: 1.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   354 QLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQE------LASLK------EQAKKEQA 421
Cdd:pfam07111   63 QQAELISRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELDALAVAEKAGQAEAeglraaLAGAEmvrknlEEGSQREL 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   422 QMVQSLQEQEQAAqgLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAeareaslRERDAARQQLETLEKEK 501
Cdd:pfam07111  143 EEIQRLHQEQLSS--LTQAHEEALSSLTSKAEGLEKSLNSLETKRAGEAKQLAEAQ-------KEAELLRKQLSKTQEEL 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   502 AAKL---ESLQQQL----------EAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEA-----AHQEQ---RQAQ-A 559
Cdd:pfam07111  214 EAQVtlvESLRKYVgeqvppevhsQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSlthmlALQEEeltRKIQpS 293

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   560 HVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLeeekhrtadalAEQQRCVTKMEAESRSLMEQRE 639
Cdd:pfam07111  294 DSLEPEFPKKCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQV-----------AELQEQVTSQSQEQAILQRALQ 362

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   640 QEQKALEQEKAGRKGLEARLQQLEEArqaetealRRELAEATASqhrAESESEQLIREVESWQKRFEAR----QQEEARY 715
Cdd:pfam07111  363 DKAAEVEVERMSAKGLQMELSRAQEA--------RRRQQQQTAS---AEEQLKFVVNAMSSTQIWLETTmtrvEQAVARI 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   716 SAMIQEQLAALKGDHEKAGQEAQEEAVevhgeGQIGEQQSPLAQ----LHTTLARALQQVKEKEVRAQkladdlttlqek 791
Cdd:pfam07111  432 PSLSNRLSYAVRKVHTIKGLMARKVAL-----AQLRQESCPPPPpappVDADLSLELEQLREERNRLD------------ 494

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   792 mASTSKVAACLKTLVLKAGEQQEMTSLELlkeppgagNKESNWLEEQrggpfsspqaaLKAMEQEAEQMGSELERLRVAL 871
Cdd:pfam07111  495 -AELQLSAHLIQQEVGRAREQGEAERQQL--------SEVAQQLEQE-----------LQRAQESLASVGQQLEVARQGQ 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   872 MKSqgqqqeergqqEREVARLTRERSQAQ---ADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEA--------LDHALT 940
Cdd:pfam07111  555 QES-----------TEEAASLRQELTQQQeiyGQALQEKVAEVETRLREQLSDTKRRLNEARREQAkavvslrqIQHRAT 623

                          650       660       670
                   ....*....|....*....|....*....|....
gi 344240178   941 EKEGKDQELAKLrgQEAAQRTELKELQQTLEHLK 974
Cdd:pfam07111  624 QEKERNQELRRL--QDEARKEEGQRLARRVQELE 655
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 277-531 1.49e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 56.38  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  277 KLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLlaerghfEEEKQQLA 356
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI-------EERREELG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  357 SLIADLQSSISNLSQAKEELEQASQA---QGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQA 433
Cdd:COG3883    90 ERARALYRSGGSVSYLDVLLGSESFSdflDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  434 AQGLRQQVEQLSSSL-KLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQL 512
Cdd:COG3883   170 KAELEAQQAEQEALLaQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGA 249

                         250
                  ....*....|....*....
gi 344240178  513 EAANEARDSVQTSVTQVQQ 531
Cdd:COG3883   250 GAAGAAGAAAGSAGAAGAA 268
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
931-1396 1.66e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 57.08  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  931 LQEALDHALTEK-EGKDQELAKLRGQEAA-QRTELKELQQTLEHLKTQL--VKKEKEQHPAGSTGGEEASAPEAQLETVR 1006
Cdd:COG4717    39 LLAFIRAMLLERlEKEADELFKPQGRKPElNLKELKELEEELKEAEEKEeeYAELQEELEELEEELEELEAELEELREEL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1007 KTEAPDPEVEALRAEVSKLEQQCQQQKQQVEglthSLESERASRAEQDKALETLQGQLEEKTQELG-HSQAASASAQREL 1085
Cdd:COG4717   119 EKLEKLLQLLPLYQELEALEAELAELPERLE----ELEERLEELRELEEELEELEAELAELQEELEeLLEQLSLATEEEL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1086 TALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILN--RQVLEKEGESKELKRLVVAESEKSQKLEERLR 1163
Cdd:COG4717   195 QDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAAleERLKEARLLLLIAAALLALLGLGGSLLSLILT 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1164 LLQVETASSSARAAERSSALREE--VQSLREEVEKQRVISENLRQELTSQAER-----------AEELGQELKAWQEKFF 1230
Cdd:COG4717   275 IAGVLFLVLGLLALLFLLLAREKasLGKEAEELQALPALEELEEEELEELLAAlglppdlspeeLLELLDRIEELQELLR 354

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1231 QKEQALSALQLEHtsTQALVSELLPAKHLCQQLQAEQAAAEKRHREEieqskqaaggLRAELMRAQRELGELGPLRQKVA 1310
Cdd:COG4717   355 EAEELEEELQLEE--LEQEIAALLAEAGVEDEEELRAALEQAEEYQE----------LKEELEELEEQLEELLGELEELL 422

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1311 EQ------ERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHL 1384
Cdd:COG4717   423 EAldeeelEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELL 502

                         490
                  ....*....|..
gi 344240178 1385 AEMRQEAQSTTR 1396
Cdd:COG4717   503 EEAREEYREERL 514
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 159-408 2.09e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  159 QAASSQESRELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEengdlsfKVREFASHLQQLQGAFNDLTEE 238
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALAR-------RIRALEQELAALEAELAELEKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  239 HNKASQEWAEKQTHLEKELSTALQdkkyleekneilQGKLSQLEERASQQCESPAQEKGEVLGDALQleTLKQEAAKLAA 318
Cdd:COG4942    92 IAELRAELEAQKEELAELLRALYR------------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAP--ARREQAEELRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  319 HNTQLQARIETLDCERSQQEAQLLAErghfEEEKQQLASLIADLQSSISNLSQAKEELEQASqaqgAQLTAQVASLTALN 398
Cdd:COG4942   158 DLAELAALRAELEAERAELEALLAEL----EEERAALEALKAERQKLLARLEKELAELAAEL----AELQQEAEELEALI 229

                         250
                  ....*....|
gi 344240178  399 TTLQQQQDQE 408
Cdd:COG4942   230 ARLEAEAAAA 239
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1208-1486 2.30e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1208 LTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELlpakhlcqqlqaeqaaaekrhREEIEQSKQAAGG 1287
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL---------------------ERRIAALARRIRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1288 LRAELMRAQRELGELGplrqkvAEQERAAQQLRAEKASYAEQLSMLKKAhgllaeenrGLGERANLGRQFLEVELDQARE 1367
Cdd:COG4942    74 LEQELAALEAELAELE------KEIAELRAELEAQKEELAELLRALYRL---------GRQPPLALLLSPEDFLDAVRRL 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1368 KYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKvq 1447
Cdd:COG4942   139 QYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA-- 216

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 344240178 1448 qqklkafqaqggESQQEVQRLQAQLNELQTQLSQKEQAA 1486
Cdd:COG4942   217 ------------ELQQEAEELEALIARLEAEAAAAAERT 243
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 223-676 2.44e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 56.67  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   223 SHLQQLQGAFNDLTEEHNKASQEwaekqthLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCES----------- 291
Cdd:pfam05557    9 ARLSQLQNEKKQMELEHKRARIE-------LEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEAlreqaelnrlk 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   292 ---------PAQEKGEVLGDALQLET-LKQEAAKLA--AHNTQLQARIETLDCERSQQEAQLLAERGhfeeekQQLASLI 359
Cdd:pfam05557   82 kkylealnkKLNEKESQLADAREVIScLKNELSELRrqIQRAELELQSTNSELEELQERLDLLKAKA------SEAEQLR 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   360 ADLQSSISNLSQAKE---ELEQ--ASQAQGAQLT----AQVASLTALNTTLQQQQDQ--ELASLKEQAK--KEQAQMVQS 426
Cdd:pfam05557  156 QNLEKQQSSLAEAEQrikELEFeiQSQEQDSEIVknskSELARIPELEKELERLREHnkHLNENIENKLllKEEVEDLKR 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   427 LQEQEQAAQglrqqvEQLsSSLKLKEQQLEEAAKDQEAARQDHAqqlaivaeareASLRERDAARQQLETLEKEKAAkle 506
Cdd:pfam05557  236 KLEREEKYR------EEA-ATLELEKEKLEQELQSWVKLAQDTG-----------LNLRSPEDLSRRIEQLQQREIV--- 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   507 sLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEK- 585
Cdd:pfam05557  295 -LKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSn 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   586 --AQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQkaLEQEKAGRKGLEARLQQLE 663
Cdd:pfam05557  374 ysPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQES--LADPSYSKEEVDSLRRKLE 451

                          490
                   ....*....|...
gi 344240178   664 EARqAETEALRRE 676
Cdd:pfam05557  452 TLE-LERQRLREQ 463
PRK11637 PRK11637
AmiB activator; Provisional
 350-585 2.61e-07

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 55.85  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  350 EEKQQLASLIADLQSSISNLSQAKEELEQaSQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQA----KKEQAQMVQ 425
Cdd:PRK11637   65 QQQQQRASLLAQLKKQEEAISQASRKLRE-TQNTLNQLNKQIDELNASIAKLEQQQAAQERLLAAQLdaafRQGEHTGLQ 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  426 SLQEQEQAaqglrQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQlaivaearEASLRERDAARQQLETLEKEKaakl 505
Cdd:PRK11637  144 LILSGEES-----QRGERILAYFGYLNQARQETIAELKQTREELAAQ--------KAELEEKQSQQKTLLYEQQAQ---- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  506 eslQQQLEAANEARD----SVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRqAQAhvtELEAQlkaEQQKVAEREKV 581
Cdd:PRK11637  207 ---QQKLEQARNERKktltGLESSLQKDQQQLSELRANESRLRDSIARAEREAK-ARA---EREAR---EAARVRDKQKQ 276


                  ....
gi 344240178  582 MQEK 585
Cdd:PRK11637  277 AKRK 280
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1094-1574 2.74e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 56.77  E-value: 2.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1094 DHSKAEEEWKAQVARGQQEAERKSSLISSLeeevSILNRQVLEKEGESKELKRlvvAESEKSQKLEERLRLLQVETASSS 1173
Cdd:pfam12128  231 QAIAGIMKIRPEFTKLQQEFNTLESAELRL----SHLHFGYKSDETLIASRQE---ERQETSAELNQLLRTLDDQWKEKR 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1174 ARAAERSSALREEVQSLREEVEkqrVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQA----- 1248
Cdd:pfam12128  304 DELNGELSAADAAVAKDRSELE---ALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAkynrr 380

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1249 --LVSELLPAK---------------------------HLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQREL 1299
Cdd:pfam12128  381 rsKIKEQNNRDiagikdklakireardrqlavaeddlqALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATP 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1300 GELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGeRANLGRQFLEVELDQAREKYVQE----LAA 1375
Cdd:pfam12128  461 ELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALR-QASRRLEERQSALDELELQLFPQagtlLHF 539

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1376 VRTDA---ETHLAEMRQEAQSTTRELE-VMTAKYEGAKVKVLEERQRFQE-ERQKLTAQVEELSKKLTEYDQASKVQQQK 1450
Cdd:pfam12128  540 LRKEApdwEQSIGKVISPELLHRTDLDpEVWDGSVGGELNLYGVKLDLKRiDVPEWAASEEELRERLDKAEEALQSAREK 619

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1451 LKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQ-----AAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENK 1525
Cdd:pfam12128  620 QAAAEEQLVQANGELEKASREETFARTALKNARLdlrrlFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQ 699

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 344240178  1526 ELRAEAERLGRELQQAGL-KTKEAEQAcrhLSAQVRSLEAQVAHADQQLR 1574
Cdd:pfam12128  700 AWLEEQKEQKREARTEKQaYWQVVEGA---LDAQLALLKAAIAARRSGAK 746
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 459-693 2.84e-07

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 56.49  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  459 AKDQEAARQDHAqqlaivaeareaslRERDAARQQleTLEKEKAAKLESLQQQLEA-ANEARDSVQTSVTQVQQEKAELS 537
Cdd:PRK05035  440 AIEQEKKKAEEA--------------KARFEARQA--RLEREKAAREARHKKAAEArAAKDKDAVAAALARVKAKKAAAT 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  538 QKIEELH----------ACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLE 607
Cdd:PRK05035  504 QPIVIKAgarpdnsaviAAREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVA 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  608 EEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAgRKGLEARLQQLEEARQAETEALRRELAEATA---SQ 684
Cdd:PRK05035  584 AAIARAKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKA-KKAEQQANAEPEEPVDPRKAAVAAAIARAKArkaAQ 662


                  ....*....
gi 344240178  685 HRAESESEQ 693
Cdd:PRK05035  663 QQANAEPEE 671
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 403-571 2.94e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.16  E-value: 2.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  403 QQQDQELASLKEQAKKEQAQmVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAearea 482
Cdd:COG1579    13 QELDSELDRLEHRLKELPAE-LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR----- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  483 SLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVT 562
Cdd:COG1579    87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                  ....*....
gi 344240178  563 ELEAQLKAE 571
Cdd:COG1579   167 ELAAKIPPE 175
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 402-599 2.96e-07

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 55.58  E-value: 2.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  402 QQQQDQELASLKEQAKKEQAQMVQSLQEQEQAA--QGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQlaivAEA 479
Cdd:PRK09510   66 RQQQQQKSAKRAEEQRKKKEQQQAEELQQKQAAeqERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAA----AKA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  480 REASLRERDAARQQLETLEK---EKAAKLESLQQQLEAANEARdsvQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQ 556
Cdd:PRK09510  142 AAAAKAKAEAEAKRAAAAAKkaaAEAKKKAEAEAAKKAAAEAK---KKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKK 218

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 344240178  557 AQAHVTELEAQLKAEQQKVAEREKVMQ--EKAQLQEQLLALEETL 599
Cdd:PRK09510  219 AAAEAKAAAAKAAAEAKAAAEKAAAAKaaEKAAAAKAAAEVDDLF 263
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1358-1572 3.13e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.54  E-value: 3.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1358 LEVELDQAREKyVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKL 1437
Cdd:COG4942    32 LQQEIAELEKE-LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1438 TEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDL 1517
Cdd:COG4942   111 RALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAAL 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178 1518 EQLQKENKELRAEAERLGRELQQAGLKTKEAEQAcrhLSAQVRSLEAQVAHADQQ 1572
Cdd:COG4942   191 EALKAERQKLLARLEKELAELAAELAELQQEAEE---LEALIARLEAEAAAAAER 242
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 107-543 3.42e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 3.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   107 MRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLALLN-EKQAASSQESRELEELRGKNESLtvrlhe 185
Cdd:TIGR04523  309 NKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENsEKQRELEEKQNEIEKLKKENQSY------ 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   186 tLKQCQNLKTEKNQMDRKISQLSEENgdlsfkvrefashlQQLQGAFNDLTEEHNKASQEwaekQTHLEKELSTALQDKK 265
Cdd:TIGR04523  383 -KQEIKNLESQINDLESKIQNQEKLN--------------QQKDEQIKKLQQEKELLEKE----IERLKETIIKNNSEIK 443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   266 YLEEKNEILQGKLSQLEERASQQCEspaqekgevlgdalQLETLKQEAAKLAAHNTQLQARIEtldcersQQEAQLLAer 345
Cdd:TIGR04523  444 DLTNQDSVKELIIKNLDNTRESLET--------------QLKVLSRSINKIKQNLEQKQKELK-------SKEKELKK-- 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   346 ghFEEEKQQLASLIADLQSSISNLSQAKEELEqasqaqgaqltaqvasltalntTLQQQQDQELASLKEQAKKEQAQMVQ 425
Cdd:TIGR04523  501 --LNEEKKELEEKVKDLTKKISSLKEKIEKLE----------------------SEKKEKESKISDLEDELNKDDFELKK 556

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   426 SLQEQEqaAQGLRQQVEQL---SSSLKLKEQQLEEAAKDQEAARQDHAQQLA---IVAEAREASLRERDAARQQLETLEK 499
Cdd:TIGR04523  557 ENLEKE--IDEKNKEIEELkqtQKSLKKKQEEKQELIDQKEKEKKDLIKEIEekeKKISSLEKELEKAKKENEKLSSIIK 634

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 344240178   500 EKAAKLESLQQQLEAaneardsVQTSVTQVQQEKAELSQKIEEL 543
Cdd:TIGR04523  635 NIKSKKNKLKQEVKQ-------IKETIKEIRNKWPEIIKKIKES 671
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1416-1587 3.46e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.18  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1416 RQRFQEERQKLTAQVEELSKKLTEydqaskvQQQKLKAFQAQ------GGESQQEVQR---LQAQLNELQTQLSQKEQAA 1486
Cdd:COG3206   170 REEARKALEFLEEQLPELRKELEE-------AEAALEEFRQKnglvdlSEEAKLLLQQlseLESQLAEARAELAEAEARL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1487 EHYKLQMEKAKTH---------YDAKKQQNQELQDQLRDLEQLQKEN----KELRAEAERLGRELQQAGLKTK-EAEQAC 1552
Cdd:COG3206   243 AALRAQLGSGPDAlpellqspvIQQLRAQLAELEAELAELSARYTPNhpdvIALRAQIAALRAQLQQEAQRILaSLEAEL 322

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 344240178 1553 RHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALK 1587
Cdd:COG3206   323 EALQAREASLQAQLAQLEARLAELPELEAELRRLE 357
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 900-1533 3.46e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 56.39  E-value: 3.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   900 QADLAQEKAAKAELE------VRLQNTLNEQRVEFAALQEALDHALTEKEGKDQEL-AKLRGQEAAQRTELKELQQTLEH 972
Cdd:pfam12128  247 QQEFNTLESAELRLShlhfgyKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKrDELNGELSAADAAVAKDRSELEA 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   973 LKTQL----------VKKEKEQHPAGSTGGEEASAP-EAQLETVRKTEApdpEVEALRAEVSkleqqcQQQKQQVEGLTH 1041
Cdd:pfam12128  327 LEDQHgafldadietAAADQEQLPSWQSELENLEERlKALTGKHQDVTA---KYNRRRSKIK------EQNNRDIAGIKD 397

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1042 SLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAK----AQDHSKAEEEWKAQVARGQQEAERKS 1117
Cdd:pfam12128  398 KLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGelklRLNQATATPELLLQLENFDERIERAR 477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1118 SLISSLEEEVSILNRQVLEKEGESKELKRlvvAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKq 1197
Cdd:pfam12128  478 EEQEAANAEVERLQSELRQARKRRDQASE---ALRQASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQSIGK- 553

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1198 rVISenlrQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLE--HTSTQALVSELLPAKhlcqQLQAEQAAAEKRHR 1275
Cdd:pfam12128  554 -VIS----PELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPewAASEEELRERLDKAE----EALQSAREKQAAAE 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1276 EEIEQSKQAAGGLRAELMRAQREL--GELGPLR---QKVAEQERAAQQLRAEKASYAE-------QLSMLKKAHGLLAEE 1343
Cdd:pfam12128  625 EQLVQANGELEKASREETFARTALknARLDLRRlfdEKQSEKDKKNKALAERKDSANErlnsleaQLKQLDKKHQAWLEE 704

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1344 NRG----LGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQST--------------TRELEVMTAKY 1405
Cdd:pfam12128  705 QKEqkreARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALETWYKRDlaslgvdpdviaklKREIRTLERKI 784

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1406 EGAKV---KVLE-----------ERQRFQEERQKLTAQVEELSKKLTEYDQASKVQqqkLKAFQAQGGESqqevQRLQAQ 1471
Cdd:pfam12128  785 ERIAVrrqEVLRyfdwyqetwlqRRPRLATQLSNIERAISELQQQLARLIADTKLR---RAKLEMERKAS----EKQQVR 857

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178  1472 LNELQTQLsqkeqaaehyKLQMEK-AKTHYDAKKQQNQ-ELQDQLRDLEQLQKENKELRAEAER 1533
Cdd:pfam12128  858 LSENLRGL----------RCEMSKlATLKEDANSEQAQgSIGERLAQLEDLKLKRDYLSESVKK 911
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
585-1071 3.58e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.93  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  585 KAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEE 664
Cdd:COG4717    44 RAMLLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  665 ARQA-----ETEALRRELAEataSQHRAESESEQlIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQE 739
Cdd:COG4717   124 LLQLlplyqELEALEAELAE---LPERLEELEER-LEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  740 EAVEVhgEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLE 819
Cdd:COG4717   200 ELEEL--QQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAG 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  820 LLKEPPGAGNKESNWLEEQRGGPFSSPQAALKAMEQEAEQmGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQA 899
Cdd:COG4717   278 VLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELE-EEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  900 QAdlAQEKAAKAELEVRLQNTLNEQRVEFAalqEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVK 979
Cdd:COG4717   357 EE--LEEELQLEELEQEIAALLAEAGVEDE---EELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  980 KEKEQHpagstgGEEASAPEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEglTHSLESERASRAEQDKALET 1059
Cdd:COG4717   432 EELEEL------EEELEELEEELEELRE------ELAELEAELEQLEEDGELAELLQE--LEELKAELRELAEEWAALKL 497

                         490
                  ....*....|..
gi 344240178 1060 LQGQLEEKTQEL 1071
Cdd:COG4717   498 ALELLEEAREEY 509
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 228-689 3.69e-07

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 55.67  E-value: 3.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   228 LQGAFNDLTEEHNKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQEKGEVLGDALQLE 307
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   308 TLKQEAAKLAAHNTQLQARIETLdcersQQEAQLLAERGHFEEekqqlasliadlqssiSNLSQAKEELEQAsqaqGAQL 387
Cdd:pfam07888  112 ELSEEKDALLAQRAAHEARIREL-----EEDIKTLTQRVLERE----------------TELERMKERAKKA----GAQR 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   388 TAQVASLTALNTTLQQQQdQELASLkeqaKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLklkeqqleeaakdqEAARQ 467
Cdd:pfam07888  167 KEEEAERKQLQAKLQQTE-EELRSL----SKEFQELRNSLAQRDTQVLQLQDTITTLTQKL--------------TTAHR 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   468 DHAQQLAIVAEAReaSLRERDAARQQletlekekaaKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACI 547
Cdd:pfam07888  228 KEAENEALLEELR--SLQERLNASER----------KVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLAL 295

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   548 eaahqeqRQAQAHvtelEAQLKAEQQKVAEREKVMQEKaqLQEQLLALEETLQ-------ITKGSLEEEKHRTADALAEQ 620
Cdd:pfam07888  296 -------REGRAR----WAQERETLQQSAEADKDRIEK--LSAELQRLEERLQeermereKLEVELGREKDCNRVQLSES 362

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178   621 QRCVTKMEAESRSLmeQREQEQKALEQEKAGR--KGLEARLQQLEEARQAETEALRRELAEATASQHRAES 689
Cdd:pfam07888  363 RRELQELKASLRVA--QKEKEQLQAEKQELLEyiRQLEQRLETVADAKWSEAALTSTERPDSPLSDSEDEN 431
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1175-1603 3.76e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 56.11  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1175 RAAERSSALREEVQSLREEVEKQRvisenlrQELTSQAERAEELGQELKawqekffQKEQALSALQLEHTSTQ---ALVS 1251
Cdd:COG3096   275 RHANERRELSERALELRRELFGAR-------RQLAEEQYRLVEMARELE-------ELSARESDLEQDYQAASdhlNLVQ 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1252 ELLpakhlcqqlqaeqaaaekRHREEIEqskqaagglraelmRAQRELGELgplRQKVAEQERAAQQLRAEKASYAEQLS 1331
Cdd:COG3096   341 TAL------------------RQQEKIE--------------RYQEDLEEL---TERLEEQEEVVEEAAEQLAEAEARLE 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1332 M----LKKAHGLLAEENRGLGE---RANLGRQFLEVeLDQAREkyVQELAAVRTD-AETHLAEMRQEAQSTTRELEVMTA 1403
Cdd:COG3096   386 AaeeeVDSLKSQLADYQQALDVqqtRAIQYQQAVQA-LEKARA--LCGLPDLTPEnAEDYLAAFRAKEQQATEEVLELEQ 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1404 KYEGAKvkvlEERQRFQEERQKLTAQVEELSKklteyDQASKVQQQKLKAFQAQGGESQQEVQrLQAQLNELQTQLSQKE 1483
Cdd:COG3096   463 KLSVAD----AARRQFEKAYELVCKIAGEVER-----SQAWQTARELLRRYRSQQALAQRLQQ-LRAQLAELEQRLRQQQ 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1484 QAAE-------HYKLQMEKA---KTHYDAKKQQNQELQDQLR----DLEQLQKENKELRAEAERLG------RELQQAgl 1543
Cdd:COG3096   533 NAERlleefcqRIGQQLDAAeelEELLAELEAQLEELEEQAAeaveQRSELRQQLEQLRARIKELAarapawLAAQDA-- 610

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1544 ktkeAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRepqKPQLDLSIDSL 1603
Cdd:COG3096   611 ----LERLREQSGEALADSQEVTAAMQQLLEREREATVERDELAAR---KQALESQIERL 663
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 522-799 3.80e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 55.24  E-value: 3.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   522 VQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQI 601
Cdd:TIGR02794   34 GAEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQ 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   602 tkgslEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEAT 681
Cdd:TIGR02794  114 -----AEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAK 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   682 ASQHRAESESEQLireveswqkrfEARQQEEARYSAMiQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLH 761
Cdd:TIGR02794  189 AKAEEAKAKAEAA-----------KAKAAAEAAAKAE-AEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAA 256

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 344240178   762 TT------LARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVA 799
Cdd:TIGR02794  257 AGsevdkyAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDGTLL 300
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1090-1218 6.08e-07

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 55.25  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1090 AKAQDHSKAEEEWKAQVARGQQEAERkssliSSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVEt 1169
Cdd:COG2433   383 EELIEKELPEEEPEAEREKEHEEREL-----TEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSE- 456

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 344240178 1170 ASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELtsqaERAEEL 1218
Cdd:COG2433   457 ERREIRKDREISRLDREIERLERELEEERERIEELKRKL----ERLKEL 501
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 941-1576 6.22e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 55.73  E-value: 6.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  941 EKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQhpagSTGGEEASAPEAQLETVRKTEAPDPEVEALRA 1020
Cdd:COG3096   279 ERRELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARE----SDLEQDYQAASDHLNLVQTALRQQEKIERYQE 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1021 EVSKLEQQCQQQKQQVEGLTHSLES--ERASRAEQDkaLETLQGQLEEKTQELGHSQAASASAQRELTALhAKAQDHSKA 1098
Cdd:COG3096   355 DLEELTERLEEQEEVVEEAAEQLAEaeARLEAAEEE--VDSLKSQLADYQQALDVQQTRAIQYQQAVQAL-EKARALCGL 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1099 EEEWKAQVARGQQEAERKsslisslEEEVSilnRQVLEKEgeskelKRLVVAESEKSQkLEERLRLLQvetasSSARAAE 1178
Cdd:COG3096   432 PDLTPENAEDYLAAFRAK-------EQQAT---EEVLELE------QKLSVADAARRQ-FEKAYELVC-----KIAGEVE 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1179 RSSALREEVQSLREEVEKQrvisenlrqeltSQAERAEELGQELKAWQEKFFQKEQAlsalqlehtstQALVSELLPAKH 1258
Cdd:COG3096   490 RSQAWQTARELLRRYRSQQ------------ALAQRLQQLRAQLAELEQRLRQQQNA-----------ERLLEEFCQRIG 546

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1259 LCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPL--------------------------------- 1305
Cdd:COG3096   547 QQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARikelaarapawlaaqdalerlreqsgealadsq 626

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1306 -----RQKVAEQERAAQ----QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN---LGRQFLEVELDQARE---KY- 1369
Cdd:COG3096   627 evtaaMQQLLEREREATverdELAARKQALESQIERLSQPGGAEDPRLLALAERLGgvlLSEIYDDVTLEDAPYfsaLYg 706

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1370 -------VQELAAVRtdaeTHLAEMR-------------QEAQSTTRELEVMtakyEGAKVKVLEERQ----RF------ 1419
Cdd:COG3096   707 parhaivVPDLSAVK----EQLAGLEdcpedlyliegdpDSFDDSVFDAEEL----EDAVVVKLSDRQwrysRFpevplf 778

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1420 ----QEER-QKLTAQVEELSKkltEYDQASKVQQ------QKLKAFQAQG------GESQQEVQRLQAQLNELQTQLSQK 1482
Cdd:COG3096   779 graaREKRlEELRAERDELAE---QYAKASFDVQklqrlhQAFSQFVGGHlavafaPDPEAELAALRQRRSELERELAQH 855

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1483 EQAAEHYKLQMEKAKTHYdakkQQNQELQDQL-----RDLEQLQKENKELRAEAERLGRELQQAGLKTKEAE---QACRH 1554
Cdd:COG3096   856 RAQEQQLRQQLDQLKEQL----QLLNKLLPQAnlladETLADRLEELREELDAAQEAQAFIQQHGKALAQLEplvAVLQS 931

                         730       740
                  ....*....|....*....|..
gi 344240178 1555 LSAQVRSLEAQVAHADQQLRDL 1576
Cdd:COG3096   932 DPEQFEQLQADYLQAKEQQRRL 953
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
847-1249 6.60e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.16  E-value: 6.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  847 QAALKAMEQEAEQMGSELERLRVALmkSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELE------VRLQNT 920
Cdd:COG4717    87 EEEYAELQEELEELEEELEELEAEL--EELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEerleelRELEEE 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  921 LNEQRVEFAALQEALDHAL------TEKEGKD--QELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGS--- 989
Cdd:COG4717   165 LEELEAELAELQEELEELLeqlslaTEEELQDlaEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALeer 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  990 -TGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQ-LEEK 1067
Cdd:COG4717   245 lKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEeLEEL 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1068 TQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRL 1147
Cdd:COG4717   325 LAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEEL 404

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1148 VVAESEKSQKLEERLRLLQVETAsssARAAERSSALREEVQSLREEVEKQRVISENLRQELtSQAERAEELgQELKAWQE 1227
Cdd:COG4717   405 EELEEQLEELLGELEELLEALDE---EELEEELEELEEELEELEEELEELREELAELEAEL-EQLEEDGEL-AELLQELE 479

                         410       420
                  ....*....|....*....|..
gi 344240178 1228 kffQKEQALSALQLEHTSTQAL 1249
Cdd:COG4717   480 ---ELKAELRELAEEWAALKLA 498
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
 352-456 6.83e-07

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 54.35  E-value: 6.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   352 KQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNT---TLQQQQDQELASLKEQAKKEQAQmVQSLQ 428
Cdd:TIGR04320  253 PNSLAALQAKLATAQADLAAAQTALNTAQAALTSAQTAYAAAQAALATaqkELANAQAQALQTAQNNLATAQAA-LANAE 331

                           90       100
                   ....*....|....*....|....*...
gi 344240178   429 EQEQAAQglrQQVEQLSSSLKLKEQQLE 456
Cdd:TIGR04320  332 ARLAKAK---EALANLNADLAKKQAALD 356
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 368-700 7.41e-07

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 54.84  E-value: 7.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  368 NLSQAKEELEQASQAqgaqltaqvasltaLNTTLQQQQD--QELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLS 445
Cdd:PRK04778   99 RFRKAKHEINEIESL--------------LDLIEEDIEQilEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSFG 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  446 SSLKLKEQQLEEAAKD-----QEAARQDHAQQLAIVAEAREaslrERDAARQQLE-------TLEKEKAAKLESLQ---Q 510
Cdd:PRK04778  165 PALDELEKQLENLEEEfsqfvELTESGDYVEAREILDQLEE----ELAALEQIMEeipellkELQTELPDQLQELKagyR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  511 QLEAANEARDSVQ--TSVTQVQQEKAELSQKIEELHacIEAAHQEQRQAQAHVTELEAQLKAEqqkVAEREKVMQEKAQL 588
Cdd:PRK04778  241 ELVEEGYHLDHLDieKEIQDLKEQIDENLALLEELD--LDEAEEKNEEIQERIDQLYDILERE---VKARKYVEKNSDTL 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  589 QEQLLALEETLQITKGSLEEEKHR---TADALAEQQrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEa 665
Cdd:PRK04778  316 PDFLEHAKEQNKELKEEIDRVKQSytlNESELESVR----QLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILK- 390

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 344240178  666 RQAETEALRRELAEATASQHRAESESEQLIREVES 700
Cdd:PRK04778  391 QLEEIEKEQEKLSEMLQGLRKDELEAREKLERYRN 425
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 549-751 8.08e-07

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 54.43  E-value: 8.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  549 AAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLALEETLQitkgsLEEEKHRTADALAEQQRCVTKME 628
Cdd:PRK09510   77 AEEQRKKKEQQQAEELQQKQAAEQERLKQLE---KERLAAQEQKKQAEEAAK-----QAALKQKQAEEAAAKAAAAAKAK 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  629 AESRS-----LMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQK 703
Cdd:PRK09510  149 AEAEAkraaaAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAA 228

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 344240178  704 RFEARQQEEArysamiqEQLAALKGDHEKAGQEAQEEAVEVHGEGQIG 751
Cdd:PRK09510  229 KAAAEAKAAA-------EKAAAAKAAEKAAAAKAAAEVDDLFGGLDSG 269
Caldesmon pfam02029
Caldesmon;
403-683 1.02e-06

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 54.10  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   403 QQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKdQEAARQDHAQQLAIVAEAREA 482
Cdd:pfam02029   55 QGGLDEEEAFLDRTAKREERRQKRLQEALERQKEFDPTIADEKESVAERKENNEEEEN-SSWEKEEKRDSRLGRYKEEET 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   483 SLRERDAARQQLETLEKEKAAKLE-SLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHA-CIEAAHQEQRQAQA- 559
Cdd:pfam02029  134 EIREKEYQENKWSTEVRQAEEEGEeEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFlDQKRGHPEVKSQNGe 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   560 -HVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEE----KHRTADALAEQQRCVTKMEaESRSL 634
Cdd:pfam02029  214 eEVTKLKVTTKRRQGGLSQSQEREEEAEVFLEAEQKLEELRRRRQEKESEEfeklRQKQQEAELELEELKKKRE-ERRKL 292

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 344240178   635 MEQREQEQKALEQEKAGRKGLEAR-LQQLEEARQAETEALRRELAEATAS 683
Cdd:pfam02029  293 LEEEEQRRKQEEAERKLREEEEKRrMKEEIERRRAEAAEKRQKLPEDSSS 342
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 175-564 1.28e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 53.75  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   175 KNESLTVRLHETLKQ----CQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHnkasQEWAEKQ 250
Cdd:pfam07888   28 RAELLQNRLEECLQEraelLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKH----EELEEKY 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   251 THLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCEspaqekgEVLGDALQLETLKQEAAKLAAHNTQLQArietl 330
Cdd:pfam07888  104 KELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQ-------RVLERETELERMKERAKKAGAQRKEEEA----- 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   331 dcERSQQEAQLlaerghfEEEKQQLASLIADLQSSISNLSQakeeleQASQAQgaQLTAQVASLTALNTTLQQQQDQELA 410
Cdd:pfam07888  172 --ERKQLQAKL-------QQTEEELRSLSKEFQELRNSLAQ------RDTQVL--QLQDTITTLTQKLTTAHRKEAENEA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   411 SLKEqakkeqaqmVQSLQEQEQAAQglrQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAA 490
Cdd:pfam07888  235 LLEE---------LRSLQERLNASE---RKVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARW 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   491 RQQLETL------EKEKAAKL-ESLQQQLEAANEARDSVQTSVTQVQQEK-------AELSQKIEELHACIEAAHQEQRQ 556
Cdd:pfam07888  303 AQERETLqqsaeaDKDRIEKLsAELQRLEERLQEERMEREKLEVELGREKdcnrvqlSESRRELQELKASLRVAQKEKEQ 382


                   ....*...
gi 344240178   557 AQAHVTEL 564
Cdd:pfam07888  383 LQAEKQEL 390
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
437-579 1.28e-06

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 53.13  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  437 LRQQVEQLSSSLKLKEQQLEeAAKDQEAARQDHAQQLAIVAEAR-EASLRERDAARQQleTLEKEKAAKleslQQQLEaa 515
Cdd:COG1566    81 LQAALAQAEAQLAAAEAQLA-RLEAELGAEAEIAAAEAQLAAAQaQLDLAQRELERYQ--ALYKKGAVS----QQELD-- 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178  516 nEARDSVQTSVTQVQQEKAELSQKIEELhacieAAHQEQRQAQAHVTELEAQLKAEQQKVAERE 579
Cdd:COG1566   152 -EARAALDAAQAQLEAAQAQLAQAQAGL-----REEEELAAAQAQVAQAEAALAQAELNLARTT 209
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
422-744 1.40e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 53.37  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  422 QMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEk 501
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEE- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  502 aakLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkv 581
Cdd:COG4372    82 ---LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELE-- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  582 mQEKAQLQEQLLALEETLQITKGSLEEEK----HRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEA 657
Cdd:COG4372   157 -EQLESLQEELAALEQELQALSEAEAEQAldelLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  658 RLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEA 737
Cdd:COG4372   236 SALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALED 315


                  ....*..
gi 344240178  738 QEEAVEV 744
Cdd:COG4372   316 ALLAALL 322
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
1454-1576 1.46e-06

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 53.13  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1454 FQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEhYKLQMEKAKTHYDAKKQQ---NQELQDQ----LRDLEQLQKENKE 1526
Cdd:COG1566    81 LQAALAQAEAQLAAAEAQLARLEAELGAEAEIAA-AEAQLAAAQAQLDLAQRElerYQALYKKgavsQQELDEARAALDA 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 344240178 1527 LRAEAERLGRELQQAGLKTKEAEQAcRHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:COG1566   160 AQAQLEAAQAQLAQAQAGLREEEEL-AAAQAQVAQAEAALAQAELNLART 208
PRK11637 PRK11637
AmiB activator; Provisional
 559-783 1.57e-06

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 53.54  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  559 AHVTELEAQLKAEQQKVAEREKVMQEKAQ----LQEQLLALEETLQITKGSLeeekHRTADALAEQQRCVTKMEAESRSL 634
Cdd:PRK11637   40 AHASDNRDQLKSIQQDIAAKEKSVRQQQQqrasLLAQLKKQEEAISQASRKL----RETQNTLNQLNKQIDELNASIAKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  635 MEQREQEQKALEQE--KAGRKGLEARLQ-------------------QLEEARQAETEAL---RRELAEATASQHRAESE 690
Cdd:PRK11637  116 EQQQAAQERLLAAQldAAFRQGEHTGLQlilsgeesqrgerilayfgYLNQARQETIAELkqtREELAAQKAELEEKQSQ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  691 SEQLIREVESWQKRFEARQQEEarysamiQEQLAALKGDHEKAGQeaqeeavevhgegQIGEQQSPLAQLHTTLARALQQ 770
Cdd:PRK11637  196 QKTLLYEQQAQQQKLEQARNER-------KKTLTGLESSLQKDQQ-------------QLSELRANESRLRDSIARAERE 255

                         250
                  ....*....|....*..
gi 344240178  771 VK---EKEVR-AQKLAD 783
Cdd:PRK11637  256 AKaraEREAReAARVRD 272
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 960-1583 1.60e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 53.98  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   960 RTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLE-TVRKTEAPDPEVEALRAEVSKLEQQCQQQKQQVEG 1038
Cdd:pfam05557    1 RAELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDrESDRNQELQKRIRLLEKREAEAEEALREQAELNRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1039 LTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKA---QVARGQQEAER 1115
Cdd:pfam05557   81 KKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAkasEAEQLRQNLEK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1116 KSSLISSLEEEVSILNRQVLEKEGESKELKRlVVAESEKSQKLEERLRLLQVETASSSArAAERSSALREEVQSLREEVE 1195
Cdd:pfam05557  161 QQSSLAEAEQRIKELEFEIQSQEQDSEIVKN-SKSELARIPELEKELERLREHNKHLNE-NIENKLLLKEEVEDLKRKLE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1196 KQrvisENLRQELTSQAERAEELGQELKAWqEKFFQkeqalsALQLEHTSTQALVSELlpakhlcqqlqAEQAAAEKRHR 1275
Cdd:pfam05557  239 RE----EKYREEAATLELEKEKLEQELQSW-VKLAQ------DTGLNLRSPEDLSRRI-----------EQLQQREIVLK 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1276 EEIEQSKQAAGGLRAelmrAQRELgelgplRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLgeRANLG- 1354
Cdd:pfam05557  297 EENSSLTSSARQLEK----ARREL------EQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGY--RAILEs 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1355 --RQFLEVELDQAREKYVQELAAVRTDAETHLAEMRqeAQSTTRELEVMTAKYEGAKVKV---LEERQRFQEERQKLTAQ 1429
Cdd:pfam05557  365 ydKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEME--AQLSVAEEELGGYKQQAQTLERelqALRQQESLADPSYSKEE 442

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1430 VEELSKKLTEYdqaskvqqqklkafqaqggesQQEVQRLQAQLNELQTQLSQKEQAAEH-------YKLQMEKAKTHYDA 1502
Cdd:pfam05557  443 VDSLRRKLETL---------------------ELERQRLREQKNELEMELERRCLQGDYdpkktkvLHLSMNPAAEAYQQ 501

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1503 KKQQnqelqdqlrdLEQLQKENKELRAEAERLGRELQQAGlktKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGK-FQV 1581
Cdd:pfam05557  502 RKNQ----------LEKLQAEIERLKRLLKKLEDDLEQVL---RLPETTSTMNFKEVLDLRKELESAELKNQRLKEvFQA 568


                   ..
gi 344240178  1582 AT 1583
Cdd:pfam05557  569 KI 570
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 890-1110 1.61e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  890 ARLTRERSQAQADLAQEKAAKAELEVR---LQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKEL 966
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEekaLLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  967 QQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRK-TEAPDPEVEALRA---EVSKLEQQCQQQKQQVEGLTHS 1042
Cdd:COG4942   103 KEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYlAPARREQAEELRAdlaELAALRAELEAERAELEALLAE 182

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1043 LESERAS----RAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQ 1110
Cdd:COG4942   183 LEEERAAlealKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGK 254
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 350-693 1.74e-06

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 53.81  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  350 EEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQmvQSLQE 429
Cdd:COG5185   239 QDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKAT--ESLEE 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  430 QEQAAqGLRQQVEQLS----SSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAaRQQLETLEKEKAAKL 505
Cdd:COG5185   317 QLAAA-EAEQELEESKreteTGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEEL-DSFKDTIESTKESLD 394

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  506 ESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQA------HVTELEAQLKAEQQKVAERE 579
Cdd:COG5185   395 EIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISelnkvmREADEESQSRLEEAYDEINR 474

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  580 KVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKagRKGLEARL 659
Cdd:COG5185   475 SVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENL--IPASELIQ 552

                         330       340       350
                  ....*....|....*....|....*....|....
gi 344240178  660 QQLEEARQAETEALRRELAEATASQHRAESESEQ 693
Cdd:COG5185   553 ASNAKTDGQAANLRTAVIDELTQYLSTIESQQAR 586
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
451-597 1.90e-06

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 53.34  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  451 KEQQLEEAAKDQEAARQDHAQQLAIvaEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQ 530
Cdd:COG2268   210 RETEIAIAQANREAEEAELEQEREI--ETARIAEAEAELAKKKAEERREAETARAEAEAAYEIAEANAEREVQRQLEIAE 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  531 QEKA-ELSQK-IEELHACIEAAHQEQRQAQAHVTELEAQLKAE------------QQKVAEREKVMQEKAQLQEQLLALE 596
Cdd:COG2268   288 REREiELQEKeAEREEAELEADVRKPAEAEKQAAEAEAEAEAEairakglaeaegKRALAEAWNKLGDAAILLMLIEKLP 367


                  .
gi 344240178  597 E 597
Cdd:COG2268   368 E 368
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
357-811 2.03e-06

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 53.37  E-value: 2.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  357 SLIADLQSSISNLSQAKEELEQASQAQGAQLtAQVASLTALNTTLQQQQDQELAsLKEQAKKEQAQMVQSLQEQEQAAQG 436
Cdd:COG5278    76 SFLEPYEEARAEIDELLAELRSLTADNPEQQ-ARLDELEALIDQWLAELEQVIA-LRRAGGLEAALALVRSGEGKALMDE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  437 LRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAAN 516
Cdd:COG5278   154 IRARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALE 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  517 EARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALE 596
Cdd:COG5278   234 LLAALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAA 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  597 ETLQITKGSLEEEKHRTADALAEQ--QRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALR 674
Cdd:COG5278   314 AAAAAAAAAAALAALLALALATALaaAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVL 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  675 RELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQ 754
Cdd:COG5278   394 AIAAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAA 473

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  755 SPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGE 811
Cdd:COG5278   474 LAALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALAAALASAEL 530
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1288-1596 2.10e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.62  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1288 LRAELMRAQRELGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGL---------LAEENRGLGERANLGRQFL 1358
Cdd:COG4717    76 LEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLlplyqeleaLEAELAELPERLEELEERL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1359 E--VELDQAREKYVQELAAVRTDAETHL----AEMRQEAQSTTRELEVMTAKYEGAKvkvlEERQRFQEERQKLTAQVEE 1432
Cdd:COG4717   156 EelRELEEELEELEAELAELQEELEELLeqlsLATEEELQDLAEELEELQQRLAELE----EELEEAQEELEELEEELEQ 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1433 LSKKLTEYDQASKVQQQKLKAFQA--------------------------------------QGGESQQEVQRLQAQLNE 1474
Cdd:COG4717   232 LENELEAAALEERLKEARLLLLIAaallallglggsllsliltiagvlflvlgllallflllAREKASLGKEAEELQALP 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1475 LQTQLSQKEQA--AEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERlGRELQQAGLKTKEAEQAC 1552
Cdd:COG4717   312 ALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEI-AALLAEAGVEDEEELRAA 390

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 344240178 1553 RHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQKPQL 1596
Cdd:COG4717   391 LEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEEL 434
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 908-1126 2.19e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  908 AAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPA 987
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  988 GSTGGEEASAPEAQLETVRKTEAPDPEVEALRAEVSkleQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEK 1067
Cdd:COG4942    96 RAELEAQKEELAELLRALYRLGRQPPLALLLSPEDF---LDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178 1068 TQELGHSQAASASAQRELTALHAKAQD----HSKAEEEWKAQVARGQQEAERKSSLISSLEEE 1126
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKllarLEKELAELAAELAELQQEAEELEALIARLEAE 235
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1455-1564 2.42e-06

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 53.29  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1455 QAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLR-DLEQ-LQKENKELRAEAE 1532
Cdd:PRK00409  508 KKLIGEDKEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLeEAEKeAQQAIKEAKKEAD 587

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 344240178 1533 RLGREL------QQAGLKTKEAEQACRHLSAQVRSLEA 1564
Cdd:PRK00409  588 EIIKELrqlqkgGYASVKAHELIEARKRLNKANEKKEK 625
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1175-1538 2.65e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.14  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1175 RAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELL 1254
Cdd:PRK03918  162 NAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIE 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1255 PAKhlcqQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERaaqqLRAEKASYAEQLSMLK 1334
Cdd:PRK03918  242 ELE----KELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIK----LSEFYEEYLDELREIE 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1335 KAHGLLAEENRGLGERanlgrqfleveLDQAREKyvqelaavrtdaETHLAEMRQEAQSTTRELEVMTAK---YEGAKVK 1411
Cdd:PRK03918  314 KRLSRLEEEINGIEER-----------IKELEEK------------EERLEELKKKLKELEKRLEELEERhelYEEAKAK 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1412 vLEERQRFQEERQKLTaqVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQ-----LSQKEQAA 1486
Cdd:PRK03918  371 -KEELERLKKRLTGLT--PEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGRELTE 447

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1487 EHYKLQMEKakthYDAkkqqnqELQDQLRDLEQLQKENKELRAEAERLGREL 1538
Cdd:PRK03918  448 EHRKELLEE----YTA------ELKRIEKELKEIEEKERKLRKELRELEKVL 489
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1411-1581 2.74e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 52.60  E-value: 2.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1411 KVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYK 1490
Cdd:COG4372     7 KVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1491 LQMEKAKTHYDAKKQQNQELQDQL----RDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQV 1566
Cdd:COG4372    87 EQLQAAQAELAQAQEELESLQEEAeelqEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEEL 166

                         170
                  ....*....|....*
gi 344240178 1567 AHADQQLRDLGKFQV 1581
Cdd:COG4372   167 AALEQELQALSEAEA 181
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 156-641 3.05e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 52.82  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   156 NEKQAASSQESrELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEengdLSFKVREFASHLQQLQgafnDL 235
Cdd:pfam05557  122 RAELELQSTNS-ELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKE----LEFEIQSQEQDSEIVK----NS 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   236 TEEHNKASQEWAEKQTHLE--KELSTALQDKKYLEEKNEILQGKLSQLEErasqqcespAQEKGEVLGdaLQLETLKQE- 312
Cdd:pfam05557  193 KSELARIPELEKELERLREhnKHLNENIENKLLLKEEVEDLKRKLEREEK---------YREEAATLE--LEKEKLEQEl 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   313 -AAKLAAHNTQLQARI-ETLdcerSQQEAQLLAERGHFEEEKqqlasliADLQSSISNLSQAKEELEQasqaqgaQLTAQ 390
Cdd:pfam05557  262 qSWVKLAQDTGLNLRSpEDL----SRRIEQLQQREIVLKEEN-------SSLTSSARQLEKARRELEQ-------ELAQY 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   391 VASLTALNTTLQQQqdqelaslKEQAKKEQAQMVQSLQEQEqaaqGLRQQVEQLSSSLKLKE--QQLEEAAKDQEAARQD 468
Cdd:pfam05557  324 LKKIEDLNKKLKRH--------KALVRRLQRRVLLLTKERD----GYRAILESYDKELTMSNysPQLLERIEEAEDMTQK 391

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   469 HAQQLAIVAEAREASLRERDAARQQLETLEKEkaakLESLQQQLEAA-----NEARDSVQTSVTQVQQEKAELSQKIEEL 543
Cdd:pfam05557  392 MQAHNEEMEAQLSVAEEELGGYKQQAQTLERE----LQALRQQESLAdpsysKEEVDSLRRKLETLELERQRLREQKNEL 467

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   544 HACIEaaHQEQRQ----AQAHVTELEAQ--LKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEeekhrTADAL 617
Cdd:pfam05557  468 EMELE--RRCLQGdydpKKTKVLHLSMNpaAEAYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPE-----TTSTM 540

                          490       500
                   ....*....|....*....|....
gi 344240178   618 AEQQRCVTKMEAESRSLMEQREQE 641
Cdd:pfam05557  541 NFKEVLDLRKELESAELKNQRLKE 564
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 578-712 3.12e-06

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 48.76  E-value: 3.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   578 REKVMQEKAQLQEQLLALEETLQITKGSLEEEkHRTADALAEQQRcvtKMEAESRSLmeqrEQEQKALEQEKAgrkglea 657
Cdd:pfam20492    1 REEAEREKQELEERLKQYEEETKKAQEELEES-EETAEELEEERR---QAEEEAERL----EQKRQEAEEEKE------- 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178   658 RLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEE 712
Cdd:pfam20492   66 RLEESAEMEAEEKEQLEAELAEAQEEIARLEEEVERKEEEARRLQEELEEAREEE 120
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
410-759 3.21e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 52.21  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  410 ASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQdhaqQLAIVAEAREASLRERDA 489
Cdd:COG4372    23 GILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE----ELEELNEQLQAAQAELAQ 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  490 ARQQLETLEKEKaaklESLQQQLEAANEARDsvqtsvtQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLK 569
Cdd:COG4372    99 AQEELESLQEEA----EELQEELEELQKERQ-------DLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELA 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  570 AEQQKVAEREKVMQEKaQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQrcvTKMEAESRSLMEQREQEQKALEQEK 649
Cdd:COG4372   168 ALEQELQALSEAEAEQ-ALDELLKEANRNAEKEEELAEAEKLIESLPRELAE---ELLEAKDSLEAKLGLALSALLDALE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  650 AGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGD 729
Cdd:COG4372   244 LEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLE 323

                         330       340       350
                  ....*....|....*....|....*....|
gi 344240178  730 HEKAGQEAQEEAVEVHGEGQIGEQQSPLAQ 759
Cdd:COG4372   324 LAKKLELALAILLAELADLLQLLLVGLLDN 353
growth_prot_Scy NF041483
polarized growth protein Scy;
548-1550 3.43e-06

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 53.29  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  548 EAAHQEQRQAQAHvTELEAQLKAE--QQKVAEREKVMQEkaqlqeqllaLEETLQITKGSLEEEKhrtadALAEQQRCVT 625
Cdd:NF041483   98 DARAQTQRILQEH-AEHQARLQAElhTEAVQRRQQLDQE----------LAERRQTVESHVNENV-----AWAEQLRART 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 kmEAESRSLMEQREQEQkalEQEKAGRKGLEARLQqlEEARQ---AETEALRrelAEATASQHRAESESEQLIREVESwq 702
Cdd:NF041483  162 --ESQARRLLDESRAEA---EQALAAARAEAERLA--EEARQrlgSEAESAR---AEAEAILRRARKDAERLLNAAST-- 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  703 krfearQQEEARYSAmiqEQL-AALKGDHEKAGQEAQEeaVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKL 781
Cdd:NF041483  230 ------QAQEATDHA---EQLrSSTAAESDQARRQAAE--LSRAAEQRMQEAEEALREARAEAEKVVAEAKEAAAKQLAS 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  782 ADdltTLQEKMASTSKvaACLKTLVLKAGEQQEMTSLELLKEPPGAGNKESNWLEEqrggpfSSPQAALKAMEQEAEQMG 861
Cdd:NF041483  299 AE---SANEQRTRTAK--EEIARLVGEATKEAEALKAEAEQALADARAEAEKLVAE------AAEKARTVAAEDTAAQLA 367

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  862 SELERLRVALMKSQGQQQEERGQQEREVARLTRErSQAQADLAQEKAAKA--ELEVRLQNTLNEQRVEFAALQEALDHAL 939
Cdd:NF041483  368 KAARTAEEVLTKASEDAKATTRAAAEEAERIRRE-AEAEADRLRGEAADQaeQLKGAAKDDTKEYRAKTVELQEEARRLR 446

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  940 TEKEGKDQELA----KLRGQ---EAAQRTElkELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKTEAPD 1012
Cdd:NF041483  447 GEAEQLRAEAVaegeRIRGEarrEAVQQIE--EAARTAEELLTKAKADADELRSTATAESERVRTEAIERATTLRRQAEE 524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1013 P------EVEALRAEVSKLEQQCQQQKQQVEGLTHSlESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELT 1086
Cdd:NF041483  525 TlertraEAERLRAEAEEQAEEVRAAAERAARELRE-ETERAIAARQAEAAEELTRLHTEAEERLTAAEEALADARAEAE 603

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1087 ALHAKAQDHS-----KAEEEWKAQVARGQQEAERKSSlissleEEVSILNRQVLEKEGESKELKRLVVAESEK----SQK 1157
Cdd:NF041483  604 RIRREAAEETerlrtEAAERIRTLQAQAEQEAERLRT------EAAADASAARAEGENVAVRLRSEAAAEAERlkseAQE 677

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1158 LEERLRllqVETASSSAR----AAERSSALREEVQSLREEVEKqrvISENLRQELTSQAERAEELGQELKAWQEKFFQKE 1233
Cdd:NF041483  678 SADRVR---AEAAAAAERvgteAAEALAAAQEEAARRRREAEE---TLGSARAEADQERERAREQSEELLASARKRVEEA 751

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1234 QALSALQLEHTSTQAlvSELLPAkhlcqqlqaeQAAAEKRHREEI----EQSKQAAGGLR-AELMRAQRELGELGPLRQK 1308
Cdd:NF041483  752 QAEAQRLVEEADRRA--TELVSA----------AEQTAQQVRDSVaglqEQAEEEIAGLRsAAEHAAERTRTEAQEEADR 819

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1309 V-----AEQERA---AQQLRAEKASYAEQL-SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTD 1379
Cdd:NF041483  820 VrsdayAERERAsedANRLRREAQEETEAAkALAERTVSEAIAEAERLRSDASEYAQRVRTEASDTLASAEQDAARTRAD 899

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1380 AETHLAEMRQEAQS--------TTRELEVMTAKYEGAKVKVLEE-RQRFQEERQKLTAQVEELSKKLTEydqaskvQQQK 1450
Cdd:NF041483  900 AREDANRIRSDAAAqadrligeATSEAERLTAEARAEAERLRDEaRAEAERVRADAAAQAEQLIAEATG-------EAER 972

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1451 LKAFQAQG-GESQQEVQRLQAqlnELQTQLSQKEQAAEHYK--LQMEKAKTHYDAKKQQNQELQDQLrdlEQLQKENKEL 1527
Cdd:NF041483  973 LRAEAAETvGSAQQHAERIRT---EAERVKAEAAAEAERLRteAREEADRTLDEARKDANKRRSEAA---EQADTLITEA 1046

                        1050      1060
                  ....*....|....*....|....
gi 344240178 1528 RAEAERLGRELQQAGLK-TKEAEQ 1550
Cdd:NF041483 1047 AAEADQLTAKAQEEALRtTTEAEA 1070
Rabaptin pfam03528
Rabaptin;
331-728 3.89e-06

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 52.42  E-value: 3.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   331 DCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEEleqASQAQGAQLTAQVASLTALNTTLQQQQDQ--- 407
Cdd:pfam03528    3 DEDLQQRVAELEKENAEFYRLKQQLEAEFNQKRAKFKELYLAKEE---DLKRQNAVLQEAQVELDALQNQLALARAEmen 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   408 --ELASLKEQAKKEQAQMVQSlQEQEQAAqglrqqveqlSSSLKLKEQQLEEAAKDQEAARQDHAQQlaivAEAREASLR 485
Cdd:pfam03528   80 ikAVATVSENTKQEAIDEVKS-QWQEEVA----------SLQAIMKETVREYEVQFHRRLEQERAQW----NQYRESAER 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   486 ERDAARQQLETLEKEkaaklESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEElhacieaahqeqrqAQAHVTELE 565
Cdd:pfam03528  145 EIADLRRRLSEGQEE-----ENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTE--------------AEDKIKELE 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   566 AQLKAEQQKVAEREK------------VMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRS 633
Cdd:pfam03528  206 ASKMKELNHYLEAEKscrtdlemyvavLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   634 LMEQREQEQKALEQEKagrkglearLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVeswqkrFEARQQEEA 713
Cdd:pfam03528  286 LMRDMQRMESVLTSEQ---------LRQVEEIKKKDQEEHKRARTHKEKETLKSDREHTVSIHAV------FSPAGVETS 350

                          410
                   ....*....|....*
gi 344240178   714 RYSAMIQEQLAALKG 728
Cdd:pfam03528  351 APLSNVEEQINSAHG 365
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
461-598 4.82e-06

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 51.59  E-value: 4.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  461 DQEAARQDHAQQLAiVAEAREASLRERDAARQQLETLEkekaAKLESLQQQLEAANEARDSVQT-----SVTQVQQEKAE 535
Cdd:COG1566    80 DLQAALAQAEAQLA-AAEAQLARLEAELGAEAEIAAAE----AQLAAAQAQLDLAQRELERYQAlykkgAVSQQELDEAR 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178  536 LSQkieelhaciEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEET 598
Cdd:COG1566   155 AAL---------DAAQAQLEAAQAQLAQAQAGLREEEELAAAQAQVAQAEAALAQAELNLART 208
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2231-2334 4.90e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 4.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2231 LLGAIQEGQLGIVQQLLESGSDAsgggplrNVEESEDRSwreALNLAIRLGHEAITDVLLANIKFDFRQIHE-ALLVAVD 2309
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADA-------NLQDKNGRT---ALHLAAKNGHLEIVKLLLEHADVNLKDNGRtALHYAAR 70

                           90       100
                   ....*....|....*....|....*
gi 344240178  2310 TNQPAVVRCLLarlerEKGRKVDTK 2334
Cdd:pfam12796   71 SGHLEIVKLLL-----EKGADINVK 90
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 219-548 5.05e-06

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 51.99  E-value: 5.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   219 REFASHLQQLQGAFNDLTEEHnkasqewaekqthleKELSTALQD----KKYLEEKNEILQGKLSQLEERASQQCEspaq 294
Cdd:pfam15070  165 RELKEQLAELQNGFVKLTNEN---------------MELTSALQSeqhvKKELAKKLGQLQEELGELKETLELKSQ---- 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   295 ekgevlgdalQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKE 374
Cdd:pfam15070  226 ----------EAQSLQEQRDQYLAHLQQYVAAYQQLASEKEELHKQYLLQTQLMDRLQHEEVQGKVAAEMARQELQETQE 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   375 ELEQASQaQGAQLTAQVASLtaLNTTLQQQQDQElaSLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQ 454
Cdd:pfam15070  296 RLEALTQ-QNQQLQAQLSLL--ANPGEGDGLESE--EEEEEAPRPSLSIPEDFESREAMVAFFNSALAQAEEERAELRRQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   455 LEEaakdQEAARQDHAQQlaiVAEAREASLRERDAARQQLETLEKEkaaklesLQQQLEAANEardSVQTSVTQVQQEKA 534
Cdd:pfam15070  371 LKE----QKRRCRRLAQQ---AAPAQEEPEHEAHAPGTGGDSVPVE-------VHQALQVAME---KLQSRFTELMQEKA 433

                          330
                   ....*....|....*
gi 344240178   535 ELSQKIEEL-HACIE 548
Cdd:pfam15070  434 DLKERVEELeHRCIQ 448
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1347-1573 5.14e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 51.82  E-value: 5.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1347 LGERANLGRQFLEVELDQAREKYV-----QELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKvkvlEERQRFQE 1421
Cdd:pfam07888   40 LQERAELLQAQEAANRQREKEKERykrdrEQWERQRRELESRVAELKEELRQSREKHEELEEKYKELS----ASSEELSE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1422 ERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNE-------LQTQLSQKEQAAEHYKLQME 1494
Cdd:pfam07888  116 EKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEeeaerkqLQAKLQQTEEELRSLSKEFQ 195

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  1495 KAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQL 1573
Cdd:pfam07888  196 ELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAEL 274
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 421-622 5.23e-06

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 50.06  E-value: 5.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   421 AQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIvAEAREASLRErdAARQQLETLEKE 500
Cdd:pfam04012   11 ANIHEGLDKAEDPEKMLEQAIRDMQSELVKARQALAQTIARQKQLERRLEQQTEQ-AKKLEEKAQA--ALTKGNEELARE 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   501 KAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEA--AHQEQRQAQAHVTELEAQLKAE------- 571
Cdd:pfam04012   88 ALAEKKSLEKQAEALETQLAQQRSAVEQLRKQLAALETKIQQLKAKKNLlkARLKAAKAQEAVQTSLGSLSTSsatdsfe 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 344240178   572 --QQKVAEREKVMQEKAQLqEQLLALEETLQitkgSLEEEKHRTADALAEQQR 622
Cdd:pfam04012  168 riEEKIEEREARADAAAEL-ASAVDLDAKLE----QAGIQMEVSEDVLARLKA 215
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2220-2376 6.50e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 6.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2220 IVNKKLKFPPTLLGAIQEGQLGIVQQLLESGSDAsgggplrnveESEDRSWREALNLAIRLGHEAITDVLL---ANIKFD 2296
Cdd:COG0666    47 LALADALGALLLLAAALAGDLLVALLLLAAGADI----------NAKDDGGNTLLHAAARNGDLEIVKLLLeagADVNAR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2297 FRQIHEALLVAVDTNQPAVVRCLLarlerEKGRKVDTKSFSlaffdssidgsrfapGVTPLTLACQKDLYEIAQLLMDQG 2376
Cdd:COG0666   117 DKDGETPLHLAAYNGNLEIVKLLL-----EAGADVNAQDND---------------GNTPLHLAAANGNLEIVKLLLEAG 176
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 389-745 6.60e-06

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 51.68  E-value: 6.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   389 AQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGL-RQQVEQLSSSLKlkeqqleEAAKDQEAARQ 467
Cdd:pfam09731  106 KEATKDAAEAKAQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDaIQAVKAHTDSLK-------EASDTAEISRE 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   468 DHAQQLAIVAEAREASLRERDAARQQLEtlEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEkAELSQKIEELHAci 547
Cdd:pfam09731  179 KATDSALQKAEALAEKLKEVINLAKQSE--EEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSL-AKLVDQYKELVA-- 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   548 EAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKA-----QLQEQLLALEETLQITKGSLEEEKHRTADALAEQQR 622
Cdd:pfam09731  254 SERIVFQQELVSIFPDIIPVLKEDNLLSNDDLNSLIAHAhreidQLSKKLAELKKREEKHIERALEKQKEELDKLAEELS 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   623 CVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEArlqQLEEARQAETEALRRELAEAtasqhRAESESEQLiREVEswq 702
Cdd:pfam09731  334 ARLEEVRAADEAQLRLEFEREREEIRESYEEKLRT---ELERQAEAHEEHLKDVLVEQ-----EIELQREFL-QDIK--- 401

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 344240178   703 krfEARQQEEARYSAMIQEQLAALKGDHEKAGQ--EAQEEAVEVH 745
Cdd:pfam09731  402 ---EKVEEERAGRLLKLNELLANLKGLEKATSShsEVEDENRKAQ 443
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 348-592 6.73e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 51.00  E-value: 6.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   348 FEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVasltalnttlQQQQDQELASLKEQAKKEQAQmvqsl 427
Cdd:TIGR02794   52 ANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELE----------QRAAAEKAAKQAEQAAKQAEE----- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   428 QEQEQAAQGLRQQVEQlssslKLKEQQLEEAAKDQEAARQDHAQQLaivAEAREASLRERDAARQQLETLEKEKAAKLES 507
Cdd:TIGR02794  117 KQKQAEEAKAKQAAEA-----KAKAEAEAERKAKEEAAKQAEEEAK---AKAAAEAKKKAEEAKKKAEAEAKAKAEAEAK 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   508 LQqqleaANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQ 587
Cdd:TIGR02794  189 AK-----AEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSEVDK 263


                   ....*
gi 344240178   588 LQEQL 592
Cdd:TIGR02794  264 YAAII 268
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1431-1540 7.66e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 51.78  E-value: 7.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1431 EELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQEL 1510
Cdd:COG2433   388 KELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREI 467

                          90       100       110
                  ....*....|....*....|....*....|
gi 344240178 1511 QDQLRDLEQLQKENKELRAEAERLGRELQQ 1540
Cdd:COG2433   468 SRLDREIERLERELEEERERIEELKRKLER 497
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1060-1575 8.14e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 51.72  E-value: 8.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1060 LQGQLEEKTQELGHSQAASASAQRELTALH-----AKAQDHSKAEEEWKAQVAR-GQQEAERKSSLISSLEEEVSILN-- 1131
Cdd:PRK10246  255 LQQEASRRQQALQQALAAEEKAQPQLAALSlaqpaRQLRPHWERIQEQSAALAHtRQQIEEVNTRLQSTMALRARIRHha 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1132 -RQVLEKEGESKELKRLVVAEseksqkleERLRLLQVETASSSARAAERSS------ALREEVQSLREEVEKQRVISENL 1204
Cdd:PRK10246  335 aKQSAELQAQQQSLNTWLAEH--------DRFRQWNNELAGWRAQFSQQTSdreqlrQWQQQLTHAEQKLNALPAITLTL 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1205 RQELTSQA----ERAEELGQELKAWQEKFFQKEQALSALQL---EHTSTQALVSELLP---------------AKHLCQQ 1262
Cdd:PRK10246  407 TADEVAAAlaqhAEQRPLRQRLVALHGQIVPQQKRLAQLQVaiqNVTQEQTQRNAALNemrqrykektqqladVKTICEQ 486

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1263 LQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELgELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKK------- 1335
Cdd:PRK10246  487 EARIKDLEAQRAQLQAGQPCPLCGSTSHPAVEAYQAL-EPGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKqlqrdes 565

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1336 -AHGLLAEEN------RGLGERANLGRQFLEVELD--QAREKYVQEL------AAVRTDAETHLAEMRQ-EAQSTTRELE 1399
Cdd:PRK10246  566 eAQSLRQEEQaltqqwQAVCASLNITLQPQDDIQPwlDAQEEHERQLrllsqrHELQGQIAAHNQQIIQyQQQIEQRQQQ 645

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1400 V--------MTAKYEGAKVKVLEER-------QRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQE 1464
Cdd:PRK10246  646 LltalagyaLTLPQEDEEASWLATRqqeaqswQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVHEQ 725

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1465 VQRLQAQLNELQTQLSQKEQaaehyklQMEKAKTHYDAKkQQNQELQDQLRDLEQLQKENKELRAEA--ERLGRELQQA- 1541
Cdd:PRK10246  726 CLSLHSQLQTLQQQDVLEAQ-------RLQKAQAQFDTA-LQASVFDDQQAFLAALLDEETLTQLEQlkQNLENQRQQAq 797

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 344240178 1542 GLKTKEAEQACRHLSAQ---------VRSLEAQVAHADQQLRD 1575
Cdd:PRK10246  798 TLVTQTAQALAQHQQHRpdgldltvtVEQIQQELAQLAQQLRE 840
growth_prot_Scy NF041483
polarized growth protein Scy;
220-800 8.30e-06

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 51.75  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  220 EFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKElstALQDKKYLEEKNEILQGklsQLEERASQQCESPAQEKGEV 299
Cdd:NF041483  412 EAADQAEQLKGAAKDDTKEYRAKTVELQEEARRLRGE---AEQLRAEAVAEGERIRG---EARREAVQQIEEAARTAEEL 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  300 LGDAlqletlKQEAAKLAAHNTQLQARIETLDCERS-----QQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQA-K 373
Cdd:NF041483  486 LTKA------KADADELRSTATAESERVRTEAIERAttlrrQAEETLERTRAEAERLRAEAEEQAEEVRAAAERAARElR 559

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  374 EELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQA---KKEQAQMVQSLQ-EQEQAAQGLRQQVEQLSSSLK 449
Cdd:NF041483  560 EETERAIAARQAEAAEELTRLHTEAEERLTAAEEALADARAEAeriRREAAEETERLRtEAAERIRTLQAQAEQEAERLR 639

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  450 lkeqqlEEAAKDQEAARQD------------HAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQqlEAAN- 516
Cdd:NF041483  640 ------TEAAADASAARAEgenvavrlrseaAAEAERLKSEAQESADRVRAEAAAAAERVGTEAAEALAAAQE--EAARr 711

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  517 --EARDSVQTSVTQVQQEKAELSQKIEELHACI-----EAAHQEQR---QAQAHVTELEAqlKAEQQKVAEREKVMQEKA 586
Cdd:NF041483  712 rrEAEETLGSARAEADQERERAREQSEELLASArkrveEAQAEAQRlveEADRRATELVS--AAEQTAQQVRDSVAGLQE 789

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  587 QLQEQLLAL----EETLQITKGSLEEEKHRT-ADALAEQQRCvtkmeAESRSLMEQREQEQKALEQEKAGRKGLEA---- 657
Cdd:NF041483  790 QAEEEIAGLrsaaEHAAERTRTEAQEEADRVrSDAYAERERA-----SEDANRLRREAQEETEAAKALAERTVSEAiaea 864

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  658 ---RLQQLEEARQAETEAL-RRELAEATASQHRAE-------------SESEQLIREVESWQKRFEARQQEEArysamiQ 720
Cdd:NF041483  865 erlRSDASEYAQRVRTEASdTLASAEQDAARTRADaredanrirsdaaAQADRLIGEATSEAERLTAEARAEA------E 938

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  721 EQLAALKGDHEKAGQEAQEEAVEVHGEGqIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAA 800
Cdd:NF041483  939 RLRDEARAEAERVRADAAAQAEQLIAEA-TGEAERLRAEAAETVGSAQQHAERIRTEAERVKAEAAAEAERLRTEAREEA 1017
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 2297-2813 9.26e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 51.33  E-value: 9.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2297 FRQIHEALLVAVDTNQPAVVRCLLarlerEKGRKVDTKSFSlAFFDSSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQG 2376
Cdd:cd22193    73 YYEGQTALHIAIERRQGDIVALLV-----ENGADVHAHAKG-RFFQPKYQGEGFYFGELPLSLAACTNQPDIVQYLLENE 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2377 HTIA-------RPHPVSCACLECSN---------ARRYDLL---------KFSLSRINTYRGIASrahLSLASEDAMLAA 2431
Cdd:cd22193   147 HQPAdieaqdsRGNTVLHALVTVADntkentkfvTRMYDMIlirgaklcpTVELEEIRNNDGLTP---LQLAAKMGKIEI 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2432 FQ--LSRELrrlarKEPEFKPQYIALESLCqdYGfellgmcrnqsEVTAVLNDLGEDSETEPESEGLGQAFEEGIPNlar 2509
Cdd:cd22193   224 LKyiLQREI-----KEPELRHLSRKFTDWA--YG-----------PVSSSLYDLSNVDTCEKNSVLEIIVYNSKIDN--- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2510 lrlavnyNQKQFVAHPIcQQVLSSIWcgnlagWRGSTTIWKLFVAFLIFLTMPFLCIGYWlapKSRLGhllKIPVLKFLL 2589
Cdd:cd22193   283 -------RHEMLTLEPL-NTLLQDKW------DKFAKYMFFFSFCFYLFYMIIFTLVAYY---RPRED---EPPPPLAKT 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2590 HSASYLWFL---IFLLGESLVMETQLSTFKGRSQSVW----ETSLHMIW-------VTERSEWRTEDPQFLAEVLFAV-- 2653
Cdd:cd22193   343 TKMDYMRLLgeiLVLLGGVYFFVKEIAYFLLRRSDLQssfsDSYFEILFfvqavlvILSVVLYLFAYKEYLACLVLALal 422

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2654 --TSMLSFTRlayilpAHESLGTLQISIGRMI-DDMIRFMFILMIILTAFLCGLNNIYVP--YQET--EKLGNFNETFQF 2726
Cdd:cd22193   423 gwANMLYYTR------GFQSMGIYSVMIQKVIlRDLLRFLFVYLLFLFGFAVALVSLIEKcsSDKKdcSSYGSFSDAVLE 496

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2727 LFWTMFGMEEHTVVDMPQFlvpefvgRALYGIFTIVMVIV----LLNMLIAMITNSFQKIEDDADVEWKFARSKLYL--- 2799
Cdd:cd22193   497 LFKLTIGMGDLEFQENSTY-------PAVFLILLLTYVILtfvlLLNMLIALMGETVNNVSKESKRIWKLQRAITILefe 569

                         570       580
                  ....*....|....*....|..
gi 344240178 2800 --------SYFREGLTLPVPFN 2813
Cdd:cd22193   570 ksfpecmrKAFRSGRLLKVGLC 591
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 552-741 9.39e-06

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 50.96  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  552 QEQRQAQAHVTELEAQLKAEQQKvaerEKVMQEKAQLQEQLLALEEtlqitkgsleeekhrtaDALAEQQRCVTKMEAES 631
Cdd:PRK09510   67 QQQQQKSAKRAEEQRKKKEQQQA----EELQQKQAAEQERLKQLEK-----------------ERLAAQEQKKQAEEAAK 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  632 RSLMEQREQEQKALEQEKAGRKGLEARLQQLEE-ARQAETEALRRELAEAtasQHRAESESEQLIREVESWQKRFEARQQ 710
Cdd:PRK09510  126 QAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAaAKKAAAEAKKKAEAEA---AKKAAAEAKKKAEAEAAAKAAAEAKKK 202

                         170       180       190
                  ....*....|....*....|....*....|.
gi 344240178  711 EEARYSAMiQEQLAALKGDHEKAGQEAQEEA 741
Cdd:PRK09510  203 AEAEAKKK-AAAEAKKKAAAEAKAAAAKAAA 232
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 295-477 1.08e-05

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 50.50  E-value: 1.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   295 EKGEVLgdaLQLE--TLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGhfeeEKQQLASLIADLQSSISNLSQA 372
Cdd:pfam00529   43 KAGDVL---FQLDptDYQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAI----SRQDYDGATAQLRAAQAAVKAA 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   373 KEELEQA-SQAQGAQLTAQVASLTALNTTlqqQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLklk 451
Cdd:pfam00529  116 QAQLAQAqIDLARRRVLAPIGGISRESLV---TAGALVAQAQANLLATVAQLDQIYVQITQSAAENQAEVRSELSGA--- 189

                          170       180
                   ....*....|....*....|....*.
gi 344240178   452 EQQLEEAAKDQEAARQDhAQQLAIVA 477
Cdd:pfam00529  190 QLQIAEAEAELKLAKLD-LERTEIRA 214
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 145-587 1.11e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 51.29  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   145 MQQRIDHLALLNEKQAASSQESRELEE-LRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFAS 223
Cdd:pfam07111  333 VKQLRGQVAELQEQVTSQSQEQAILQRaLQDKAAEVEVERMSAKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSS 412

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   224 HLQQLQGAFNDLTEEhnkasqewAEKQTHLEKELSTALQDKKYLEEkneiLQGKLSQLEERASQQCESPAQEKGEVLGDA 303
Cdd:pfam07111  413 TQIWLETTMTRVEQA--------VARIPSLSNRLSYAVRKVHTIKG----LMARKVALAQLRQESCPPPPPAPPVDADLS 480

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   304 LQLETLKQEAAKLAAHnTQLQARIETLDCERSQQEAQllAERGHFEEEKQQLASLIADLQSSISNLSQakeELEQASQAQ 383
Cdd:pfam07111  481 LELEQLREERNRLDAE-LQLSAHLIQQEVGRAREQGE--AERQQLSEVAQQLEQELQRAQESLASVGQ---QLEVARQGQ 554

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   384 gAQLTAQVASLTALNTTLQQQQDQEL--------ASLKEQAKKEQAQMVQSLQEQEQAAQGLRQqVEQLSSSLKLKEQQL 455
Cdd:pfam07111  555 -QESTEEAASLRQELTQQQEIYGQALqekvaeveTRLREQLSDTKRRLNEARREQAKAVVSLRQ-IQHRATQEKERNQEL 632

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   456 EeaaKDQEAARQDHAQQLAivaeareaslrerdaarQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAE 535
Cdd:pfam07111  633 R---RLQDEARKEEGQRLA-----------------RRVQELERDKNLMLATLQQEGLLSRYKQQRLLAVLPSGLDKKSV 692

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 344240178   536 LS--QKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQ 587
Cdd:pfam07111  693 VSspRPECSASAPIPAAVPTRESIKGSLTVLLDNLQGLSEAISREEAVCQEDNQ 746
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 414-532 1.17e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 50.98  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  414 EQAKKEQA-------QMVQSLQEQE-------QAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQlaIVAEA 479
Cdd:PRK00409  505 EEAKKLIGedkeklnELIASLEELEreleqkaEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQ--AIKEA 582

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 344240178  480 R-EASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQE 532
Cdd:PRK00409  583 KkEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKKKQKEKQEE 636
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
396-743 1.17e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 50.67  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  396 ALNTTLQQQQDQELASLkEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAI 475
Cdd:COG4372    24 ILIAALSEQLRKALFEL-DKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  476 VAEAREaslrERDAARQQLETLEKEKA---AKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQ 552
Cdd:COG4372   103 LESLQE----EAEELQEELEELQKERQdleQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  553 EQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESR 632
Cdd:COG4372   179 AEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILK 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  633 SLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEE 712
Cdd:COG4372   259 EIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAE 338

                         330       340       350
                  ....*....|....*....|....*....|.
gi 344240178  713 ARYSAMIQEQLAALKGDHEKAGQEAQEEAVE 743
Cdd:COG4372   339 LADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1058-1472 1.22e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 50.66  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1058 ETLQGQLEEKTQELGHSQAASASAQRELtalHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEK 1137
Cdd:pfam07888   30 ELLQNRLEECLQERAELLQAQEAANRQR---EKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKEL 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1138 EGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALR------EEVQSLREEVEKQRVISENLRQELTSQ 1211
Cdd:pfam07888  107 SASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELErmkeraKKAGAQRKEEEAERKQLQAKLQQTEEE 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1212 AERAEELGQELKAWQEkffqkEQALSALQLEHTSTQalVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAE 1291
Cdd:pfam07888  187 LRSLSKEFQELRNSLA-----QRDTQVLQLQDTITT--LTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEE 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1292 L--MRAQRELGElgplrqkvAEQERAaqqlRAEKASYAEQLSMLKKAhgLLAEENRGLGERANLGRQfleVELDQAReky 1369
Cdd:pfam07888  260 LssMAAQRDRTQ--------AELHQA----RLQAAQLTLQLADASLA--LREGRARWAQERETLQQS---AEADKDR--- 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1370 VQELAAVRTDAEthlaEMRQEAQSTTRELEVMTAKyegakvkvleerqrfqeERQKLTAQVEELSKKLTEYDQASKVQQQ 1449
Cdd:pfam07888  320 IEKLSAELQRLE----ERLQEERMEREKLEVELGR-----------------EKDCNRVQLSESRRELQELKASLRVAQK 378

                          410       420
                   ....*....|....*....|...
gi 344240178  1450 KLKAFQAQGGESQQEVQRLQAQL 1472
Cdd:pfam07888  379 EKEQLQAEKQELLEYIRQLEQRL 401
PRK11281 PRK11281
mechanosensitive channel MscK;
470-684 1.22e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 51.07  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  470 AQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLES--LQQQLEAANEARDSVQtsvtQVQQEKAELSQKIEElhaci 547
Cdd:PRK11281   21 CLSSAFARAASNGDLPTEADVQAQLDALNKQKLLEAEDklVQQDLEQTLALLDKID----RQKEETEQLKQQLAQ----- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  548 eaAHQEQRQAQAHVTELEAQLKAE-------------QQKVAEREkvmQEKAQLQEQLL--------------------- 593
Cdd:PRK11281   92 --APAKLRQAQAELEALKDDNDEEtretlstlslrqlESRLAQTL---DQLQNAQNDLAeynsqlvslqtqperaqaaly 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  594 -ALEETLQIT---KGSLEEEKhrtadALAEQQRcvTKMEAESRSLMEQREQEQKALE-----QE--KAGRKGLEARLQQL 662
Cdd:PRK11281  167 aNSQRLQQIRnllKGGKVGGK-----ALRPSQR--VLLQAEQALLNAQNDLQRKSLEgntqlQDllQKQRDYLTARIQRL 239

                         250       260
                  ....*....|....*....|....*
gi 344240178  663 EEARQAETEAL---RRELAEATASQ 684
Cdd:PRK11281  240 EHQLQLLQEAInskRLTLSEKTVQE 264
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1273-1538 1.24e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.33  E-value: 1.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1273 RHREEIEQSKQAAGGLRAELMRAQRELGEL-GPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGEra 1351
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELeKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHE-- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1352 nlgrqfLEVELDQAREKyVQELAAVRTDAETHLAEMRQ-----EAQSTTRELEVMTAKyegAKVKVLEE--------RQR 1418
Cdd:pfam01576   80 ------LESRLEEEEER-SQQLQNEKKKMQQHIQDLEEqldeeEAARQKLQLEKVTTE---AKIKKLEEdillledqNSK 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1419 FQEERQKLTAQVEELSKKLTEYDQASKV---------------------------QQQKLK-AFQAQGGESQQEVQRLQA 1470
Cdd:pfam01576  150 LSKERKLLEERISEFTSNLAEEEEKAKSlsklknkheamisdleerlkkeekgrqELEKAKrKLEGESTDLQEQIAELQA 229

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  1471 QLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGREL 1538
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDL 297
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 2649-2806 1.35e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 50.96  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2649 VLFAVTSM-LSFTRLAYILPAHESLGTLQISIGRMI-DDMIRFMFILMIILTAFLCGL-------------NNIYVPYQE 2713
Cdd:cd22196   430 VAFMVISLaLGWANVLYYTRGFQQMGIYSVMIQKMIlRDICRFLFVYLVFLFGFSAALvtliedgppkgdvNTSQKECVC 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2714 TEKLGNFNE---TFQFLFWTMFGMEEHTVVDMPQFlVPEFVgrALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEW 2790
Cdd:cd22196   510 KSGYNSYNSlysTCLELFKFTIGMGDLEFTENYKF-KEVFI--FLLISYVILTYILLLNMLIALMGETVSKIAQESKNIW 586

                         170       180
                  ....*....|....*....|...
gi 344240178 2791 KFARS-------KLYLSYFREGL 2806
Cdd:cd22196   587 KLQRAitildleKSLLRCLRDRF 609
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 305-535 1.43e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.21  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  305 QLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQasQAQG 384
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGE--RARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  385 AQLTAqvASLTALNTTLQQQQDQELASlkeqakkeQAQMVQSLQEQEQAA----QGLRQQVEQLSSSLKLKEQQLEEAAK 460
Cdd:COG3883    95 LYRSG--GSVSYLDVLLGSESFSDFLD--------RLSALSKIADADADLleelKADKAELEAKKAELEAKLAELEALKA 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  461 DQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAE 535
Cdd:COG3883   165 ELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
916-1113 1.49e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.79  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  916 RLQNTLNEQRVEFAALQEALDHALTEKEGK--DQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKE-----QHPAG 988
Cdd:COG3206   186 ELRKELEEAEAALEEFRQKNGLVDLSEEAKllLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDAlpellQSPVI 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  989 STGGEEASAPEAQLETVRKTEAPD-PEVEALRAEVSKLEQQCQQQkqqVEGLTHSLESERASRAEQDKALETLQGQLEEK 1067
Cdd:COG3206   266 QQLRAQLAELEAELAELSARYTPNhPDVIALRAQIAALRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEAR 342

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 344240178 1068 TQELGHSQAASASAQRELTALHAKAQDHSKAEEEwkAQVARGQQEA 1113
Cdd:COG3206   343 LAELPELEAELRRLEREVEVARELYESLLQRLEE--ARLAEALTVG 386
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1192-1608 1.49e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.88  E-value: 1.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1192 EEVEKQRVISEN-LRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLC---QQLQAEQ 1267
Cdd:pfam05483   88 EKIKKWKVSIEAeLKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCnllKETCARS 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1268 AAAEKRHREEIEQSKQAAGGLRA---------ELMRAQRELGELgPLRQKVAEQERAAQQLRAEkasYAEQLSMLKKAHG 1338
Cdd:pfam05483  168 AEKTKKYEYEREETRQVYMDLNNniekmilafEELRVQAENARL-EMHFKLKEDHEKIQHLEEE---YKKEINDKEKQVS 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1339 LLAEEnrgLGERANLGRQfLEVELDQAREKYVQELAAVRTDAEtHLAEMRQEAQSTTRELE--VMTAKYEGAKVKVLEER 1416
Cdd:pfam05483  244 LLLIQ---ITEKENKMKD-LTFLLEESRDKANQLEEKTKLQDE-NLKELIEKKDHLTKELEdiKMSLQRSMSTQKALEED 318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1417 --------QRFQEERQkltAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEh 1488
Cdd:pfam05483  319 lqiatktiCQLTEEKE---AQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELE- 394

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1489 yklQMEKAKTHydaKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAH 1568
Cdd:pfam05483  395 ---EMTKFKNN---KEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEH 468

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 344240178  1569 ADQQLRDLgKFQVATDALKSREPQKPQLDLSIDSLDLSLE 1608
Cdd:pfam05483  469 YLKEVEDL-KTELEKEKLKNIELTAHCDKLLLENKELTQE 507
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 425-630 1.54e-05

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 49.76  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   425 QSLQEQEQAAQGLRQQVEQLSSSLKlkeqqleeaakdqEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKE---- 500
Cdd:pfam09787    7 QELADYKQKAARILQSKEKLIASLK-------------EGSGVEGLDSSTALTLELEELRQERDLLREEIQKLRGQiqql 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   501 KAAKLESLQQQLEAANEARDSVQTSVTQVQQEK-------AELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQ 573
Cdd:pfam09787   74 RTELQELEAQQQEEAESSREQLQELEEQLATERsarreaeAELERLQEELRYLEEELRRSKATLQSRIKDREAEIEKLRN 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178   574 KVAEREKVMQEKAQLQEQLLALEETL---QITKGSLEEEKHRTADAL--AEQQRCVTKMEAE 630
Cdd:pfam09787  154 QLTSKSQSSSSQSELENRLHQLTETLiqkQTMLEALSTEKNSLVLQLerMEQQIKELQGEGS 215
PRK09039 PRK09039
peptidoglycan -binding protein;
493-620 1.63e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 49.96  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  493 QLETLEKEKAAKLES----LQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQL 568
Cdd:PRK09039   67 DLLSLERQGNQDLQDsvanLRASLSAAEAERSRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELLNQQI 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  569 kaeqqkvaerekvmqekAQLQEQLLALEETLQITKGSLEEEKHRTAD-------ALAEQ 620
Cdd:PRK09039  147 -----------------AALRRQLAALEAALDASEKRDRESQAKIADlgrrlnvALAQR 188
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
490-789 1.75e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.90  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  490 ARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLK 569
Cdd:COG4372    11 ARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQ 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  570 AEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEK 649
Cdd:COG4372    91 AAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  650 AGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGD 729
Cdd:COG4372   171 QELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEE 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  730 HEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQ 789
Cdd:COG4372   251 LLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLI 310
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
441-677 1.78e-05

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 48.67  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  441 VEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAivaeareaslrERDAARQQLETLEKEkAAKLES-LQQQLEAANE-- 517
Cdd:COG1842    18 LDKAEDPEKMLDQAIRDMEEDLVEARQALAQVIA-----------NQKRLERQLEELEAE-AEKWEEkARLALEKGREdl 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  518 ARdsvqtsvtQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEA---QLKAEQQKVAEREKVMQEKAQLQEQLLA 594
Cdd:COG1842    86 AR--------EALERKAELEAQAEALEAQLAQLEEQVEKLKEALRQLESkleELKAKKDTLKARAKAAKAQEKVNEALSG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  595 LEETlqitkgsleeekhRTADALAEQQRCVTKMEAESRSLmeqreqeqkaleQEKAGRKGLEARLQQLEEARQAETE--A 672
Cdd:COG1842   158 IDSD-------------DATSALERMEEKIEEMEARAEAA------------AELAAGDSLDDELAELEADSEVEDElaA 212


                  ....*
gi 344240178  673 LRREL 677
Cdd:COG1842   213 LKAKM 217
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
352-542 1.80e-05

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 50.26  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  352 KQQLASLIADlQSSISNLSQAKEELEQAsQAQGAQLTAQVASLTALNTTLQQQQDQEL----ASLKEQAKKEQAQMVQSL 427
Cdd:COG2268   191 RRKIAEIIRD-ARIAEAEAERETEIAIA-QANREAEEAELEQEREIETARIAEAEAELakkkAEERREAETARAEAEAAY 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  428 QEQEQAAQglRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRER---DAARQQLETLEKEKAAK 504
Cdd:COG2268   269 EIAEANAE--REVQRQLEIAEREREIELQEKEAEREEAELEADVRKPAEAEKQAAEAEAEaeaEAIRAKGLAEAEGKRAL 346

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 344240178  505 LESLQQQLEAAneARDSVQTSVTQVQQEKAELSQKIEE 542
Cdd:COG2268   347 AEAWNKLGDAA--ILLMLIEKLPEIAEAAAKPLEKIDK 382
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1379-1595 1.83e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.83  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1379 DAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQG 1458
Cdd:COG3883    20 AKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1459 GESQQEVQRLQAQ-LNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERlgre 1537
Cdd:COG3883   100 GSVSYLDVLLGSEsFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEA---- 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178 1538 lqqaglKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQKPQ 1595
Cdd:COG3883   176 ------QQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAA 227
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1044-1254 1.88e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.40  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1044 ESERASRAEQDKALETLQGQLEEKTQELghsqaasASAQRELTALHAKAQdhskaeeewkaqVARGQQEAERKSSLISSL 1123
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKEL-------EEAEAALEEFRQKNG------------LVDLSEEAKLLLQQLSEL 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1124 EEEVSILNRQVLEKEGESKELKRLV---------VAESEKSQKLEERLRLLQVETASSSARAAERSS---ALREEVQSLR 1191
Cdd:COG3206   225 ESQLAEARAELAEAEARLAALRAQLgsgpdalpeLLQSPVIQQLRAQLAELEAELAELSARYTPNHPdviALRAQIAALR 304

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178 1192 EEVEKQ-RVISENLRQELTSQAERAEELGQELKAWQEKFF---QKEQALSALQLEHTSTQALVSELL 1254
Cdd:COG3206   305 AQLQQEaQRILASLEAELEALQAREASLQAQLAQLEARLAelpELEAELRRLEREVEVARELYESLL 371
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
460-597 1.89e-05

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 49.66  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  460 KDQEAARQDHAQQLAIVAEAREAslreRDAARQQLETLEKEKAAK--LESLQQQLEAANEARDSVQTSVTQVQQ--EKAE 535
Cdd:COG1566    69 KGQVLARLDPTDLQAALAQAEAQ----LAAAEAQLARLEAELGAEaeIAAAEAQLAAAQAQLDLAQRELERYQAlyKKGA 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  536 LSQkiEELhaciEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEE 597
Cdd:COG1566   145 VSQ--QEL----DEARAALDAAQAQLEAAQAQLAQAQAGLREEEELAAAQAQVAQAEAALAQ 200
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 362-557 1.90e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 49.80  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  362 LQSSISNLSQAKEELEQASQAQGAQLTAQVAsltALNTTLQQQQDQELASLKEQAKKEQAQMvQSLQEQEQAAQGLRQQV 441
Cdd:PRK09510   67 QQQQQKSAKRAEEQRKKKEQQQAEELQQKQA---AEQERLKQLEKERLAAQEQKKQAEEAAK-QAALKQKQAEEAAAKAA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  442 EQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDS 521
Cdd:PRK09510  143 AAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAE 222

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 344240178  522 VQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQA 557
Cdd:PRK09510  223 AKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 918-1526 1.95e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   918 QNTLNEQRVEFAALQEALDhalTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQhpagstggEEASA 997
Cdd:TIGR04523  213 NKSLESQISELKKQNNQLK---DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKEL--------EQNNK 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   998 PEAQLETvrkteapdpEVEALRAEVSKLEQQCqqqkqqVEGLTHSLESERASraeQDKALETLQGQLEEKTQELGHSQAA 1077
Cdd:TIGR04523  282 KIKELEK---------QLNQLKSEISDLNNQK------EQDWNKELKSELKN---QEKKLEEIQNQISQNNKIISQLNEQ 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1078 SASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKEL-KRLVVAESEKSQ 1156
Cdd:TIGR04523  344 ISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKdEQIKKLQQEKEL 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1157 KLEERLRLLQVETasssaRAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1236
Cdd:TIGR04523  424 LEKEIERLKETII-----KNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1237 SALQLEHTSTQALVSELlpakhlcqqlqaeqaaaekrhREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVaEQERAA 1316
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDL---------------------TKKISSLKEKIEKLESEKKEKESKISDLEDELNKD-DFELKK 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1317 QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERanlgrqfleveldqarekyVQELAAVRTDAETHLAEMRQEAQSTTR 1396
Cdd:TIGR04523  557 ENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQEL-------------------IDQKEKEKKDLIKEIEEKEKKISSLEK 617

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1397 ELEVMTAKYE---GAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFqaqggesqqeVQRLQAQLN 1473
Cdd:TIGR04523  618 ELEKAKKENEklsSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDI----------IELMKDWLK 687

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  1474 ELQtqLSQKEQAAEHYKLQ-MEKAKTHYDAKKQQNQELQDQLRDLEQLQKE-NKE 1526
Cdd:TIGR04523  688 ELS--LHYKKYITRMIRIKdLPKLEEKYKEIEKELKKLDEFSKELENIIKNfNKK 740
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 305-698 1.98e-05

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 50.22  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  305 QLETLKQEAAKLAAHNTQLQARIEtlDCERSQQEAQ--LLAERGHFEEEKQQLASLIADLQSSIS---------NLSQAK 373
Cdd:PRK04778  120 DIEQILEELQELLESEEKNREEVE--QLKDLYRELRksLLANRFSFGPALDELEKQLENLEEEFSqfveltesgDYVEAR 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  374 EELEQAsQAQGAQLTAQVASLTALNTTLQQ---QQDQELAS----LKEQ----AKKEQAQMVQSLQEQeqaaqglRQQVE 442
Cdd:PRK04778  198 EILDQL-EEELAALEQIMEEIPELLKELQTelpDQLQELKAgyreLVEEgyhlDHLDIEKEIQDLKEQ-------IDENL 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  443 QLSSSLKLKEqqleeaAKDQEAARQDHAQQLaivaeareaslrerdaarqqLETLEKEKAAK------LESLQQQLEAAN 516
Cdd:PRK04778  270 ALLEELDLDE------AEEKNEEIQERIDQL--------------------YDILEREVKARkyveknSDTLPDFLEHAK 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  517 EARDSVQTSVTQVQQeKAELSQKieELHacieaahqEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEkaqLQEQLLALE 596
Cdd:PRK04778  324 EQNKELKEEIDRVKQ-SYTLNES--ELE--------SVRQLEKQLESLEKQYDEITERIAEQEIAYSE---LQEELEEIL 389

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  597 ETLQitkgSLEEEKHRTADALAEQQrcvtKMEAESRSLMEQREQE-----------------QKALEQEKAGRKGLEARL 659
Cdd:PRK04778  390 KQLE----EIEKEQEKLSEMLQGLR----KDELEAREKLERYRNKlheikryleksnlpglpEDYLEMFFEVSDEIEALA 461

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 344240178  660 QQLEEARqAETEALRRELAEATASQHRAESESEQLIREV 698
Cdd:PRK04778  462 EELEEKP-INMEAVNRLLEEATEDVETLEEETEELVENA 499
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 342-708 2.09e-05

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 50.03  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   342 LAERGHFEEEKQQLASLIADLQSSIS---NLSQAKEELEQASQaqgaQLTAQ--VASLTALNTTLQQQQDQELASLKEQA 416
Cdd:pfam05701  198 SAHAAHLEAEEHRIGAALAREQDKLNwekELKQAEEELQRLNQ----QLLSAkdLKSKLETASALLLDLKAELAAYMESK 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   417 KKEQAQMVQSLQEQEQAAQGlrqqveqlssSLKLKEQQLEEAAKDQEAARqDHAQQLAIVAeareASLRERdaarqqlet 496
Cdd:pfam05701  274 LKEEADGEGNEKKTSTSIQA----------ALASAKKELEEVKANIEKAK-DEVNCLRVAA----ASLRSE--------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   497 LEKEKAAkLESLQQQLEAAN-------EARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAhvtelEAQLK 569
Cdd:pfam05701  330 LEKEKAE-LASLRQREGMASiavssleAELNRTKSEIALVQAKEKEAREKMVELPKQLQQAAQEAEEAKS-----LAQAA 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   570 AEQQKVAeREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTA--DALAEQQRCVTKMEAESR------SLMEQREQE 641
Cdd:pfam05701  404 REELRKA-KEEAEQAKAAASTVESRLEAVLKEIEAAKASEKLALAaiKALQESESSAESTNQEDSprgvtlSLEEYYELS 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   642 QKALEQEKAGRKGLEARLQQLEEARQAETEAL-------------RRELAEATASQHRAESESEQLIREVESWQKRFEAR 708
Cdd:pfam05701  483 KRAHEAEELANKRVAEAVSQIEEAKESELRSLekleevnremeerKEALKIALEKAEKAKEGKLAAEQELRKWRAEHEQR 562
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1071-1325 2.41e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.44  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1071 LGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVa 1150
Cdd:COG3883     4 LALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1151 esEKSQKLEERLRLLQVE-----------TASSSARAAERSSALR----------EEVQSLREEVEKQRVISENLRQELT 1209
Cdd:COG3883    83 --ERREELGERARALYRSggsvsyldvllGSESFSDFLDRLSALSkiadadadllEELKADKAELEAKKAELEAKLAELE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1210 SQAERAEELGQELKAWQEkffQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLR 1289
Cdd:COG3883   161 ALKAELEAAKAELEAQQA---EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 344240178 1290 AELMRAQRELGELGPLRQKVAEQERAAQQLRAEKAS 1325
Cdd:COG3883   238 AAAAAAASAAGAGAAGAAGAAAGSAGAAGAAAGAAG 273
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1123-1534 2.45e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 49.89  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1123 LEEEVSILNRQVLEKEGESKEL--KRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVI 1200
Cdd:pfam07888    3 LDELVTLEEESHGEEGGTDMLLvvPRAELLQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1201 SEnLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQ 1280
Cdd:pfam07888   83 AE-LKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1281 SKQAAG-------GLRAELMRAQREL----GELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKK---AHGLLAEENRG 1346
Cdd:pfam07888  162 AGAQRKeeeaerkQLQAKLQQTEEELrslsKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRkeaENEALLEELRS 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1347 LGERANLGRQFLEveldqAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTakyegakVKVLEERQRFQEERQKL 1426
Cdd:pfam07888  242 LQERLNASERKVE-----GLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADAS-------LALREGRARWAQERETL 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1427 TAQVEelskklteydqASKVQQQKLKAfqaqggesqqEVQRLQAQLnelqtqlsqKEQAAEHYKLQMEKAKTHYDAKKQQ 1506
Cdd:pfam07888  310 QQSAE-----------ADKDRIEKLSA----------ELQRLEERL---------QEERMEREKLEVELGREKDCNRVQL 359

                          410       420       430
                   ....*....|....*....|....*....|.
gi 344240178  1507 NQ---ELQDQLRDLEQLQKENKELRAEAERL 1534
Cdd:pfam07888  360 SEsrrELQELKASLRVAQKEKEQLQAEKQEL 390
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1015-1546 2.88e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 49.90  E-value: 2.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1015 VEALRAEVSK---LEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAasasaqrELTALHAK 1091
Cdd:PRK01156  175 IDMLRAEISNidyLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKS-------ALNELSSL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1092 AQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEerlrllQVETAS 1171
Cdd:PRK01156  248 EDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILS------NIDAEI 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1172 SSARAAERSSalrEEVQSLREEVEKQRVISENLRQELTSQAERAEELG------QELKAWQEKFFQKEQALSALQLEHTS 1245
Cdd:PRK01156  322 NKYHAIIKKL---SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNsylksiESLKKKIEEYSKNIERMSAFISEILK 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1246 TQALVSELLpakhlcqqlqaeqaaaeKRHREEIeqskqaagglRAELMRAQRELGEL----GPLRQKVAEQERAAQQLRA 1321
Cdd:PRK01156  399 IQEIDPDAI-----------------KKELNEI----------NVKLQDISSKVSSLnqriRALRENLDELSRNMEMLNG 451

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1322 EKASYA-------EQLSMLKKAHGllaEENRGLGERANlgrqFLEVELDQAREKYVQELAAV----RTDAETHLAEMRQ- 1389
Cdd:PRK01156  452 QSVCPVcgttlgeEKSNHIINHYN---EKKSRLEEKIR----EIEIEVKDIDEKIVDLKKRKeyleSEEINKSINEYNKi 524

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1390 ---EAQSTTRELEVMTAKYEGAKVKVLEERQRfqeerqklTAQVEELSKKLTEYDQASKVQQQ-KLKAFQAQGGESQQEV 1465
Cdd:PRK01156  525 esaRADLEDIKIKINELKDKHDKYEEIKNRYK--------SLKLEDLDSKRTSWLNALAVISLiDIETNRSRSNEIKKQL 596

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1466 QRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQqnqELQDQLRDLEQLQKENKELRAE-AERLGRELQQAGLK 1544
Cdd:PRK01156  597 NDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYN---EIQENKILIEKLRGKIDNYKKQiAEIDSIIPDLKEIT 673


                  ..
gi 344240178 1545 TK 1546
Cdd:PRK01156  674 SR 675
46 PHA02562
endonuclease subunit; Provisional
 199-461 2.94e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 49.63  E-value: 2.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  199 QMDR----KISQLSEENGDLSFKVRefasHLQQLQGAFNDLTEEHNKAS-QEWAEKQTHLEKELSTALQDKKYLEEKNEI 273
Cdd:PHA02562  167 EMDKlnkdKIRELNQQIQTLDMKID----HIQQQIKTYNKNIEEQRKKNgENIARKQNKYDELVEEAKTIKAEIEELTDE 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  274 LQGKLSQLEERASqqcespaqekgevlgdalQLETLKQEAAKlaahntqLQARIETLdcersQQEAQLLAERGHFEEEKQ 353
Cdd:PHA02562  243 LLNLVMDIEDPSA------------------ALNKLNTAAAK-------IKSKIEQF-----QKVIKMYEKGGVCPTCTQ 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  354 QLASLIADLQSSISNLSQAKEELEQASQAQGA------QLTAQVASLTALNTTLqQQQDQELASLKEQAKKEQAQMvqsl 427
Cdd:PHA02562  293 QISEGPDRITKIKDKLKELQHSLEKLDTAIDEleeimdEFNEQSKKLLELKNKI-STNKQSLITLVDKAKKVKAAI---- 367

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 344240178  428 qEQEQAAQGLR-QQVEQLSSSLKLKEQQLEEAAKD 461
Cdd:PHA02562  368 -EELQAEFVDNaEELAKLQDELDKIVKTKSELVKE 401
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1411-1609 3.64e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 48.75  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1411 KVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYK 1490
Cdd:COG4372    35 KALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQ 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1491 LQMEKAKTHYDAKKQQNQELQDQLRDLEQL----QKENKELRAEAERLGRELQQAGLKTKEAEQAcrHLSAQVRSLEAQV 1566
Cdd:COG4372   115 EELEELQKERQDLEQQRKQLEAQIAELQSEiaerEEELKELEEQLESLQEELAALEQELQALSEA--EAEQALDELLKEA 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 344240178 1567 AHADQQLRDLGKFQVATDALKSREPQKPQLDLSIDSLDLSLEE 1609
Cdd:COG4372   193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLAL 235
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 749-987 3.97e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  749 QIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVaaclktlvLKAGEQQemtsLELLKEPPGAG 828
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARR--------IRALEQE----LAALEAELAEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  829 NKESNWLEEQRggpfSSPQAALKAMEQEAEQMGSElERLRVALmksQGQQQEERGQQEREVARLTRERSQAQADLAQEKA 908
Cdd:COG4942    89 EKEIAELRAEL----EAQKEELAELLRALYRLGRQ-PPLALLL---SPEDFLDAVRRLQYLKYLAPARREQAEELRADLA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  909 AKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPA 987
Cdd:COG4942   161 ELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
381-513 4.20e-05

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 48.51  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  381 QAQGAQLTAQVASLTA--LNTTLQQQQDQELASLKEQAKKEQAQMVQsLQEQEQAAQGLRQQveQLSSslklkEQQLEEA 458
Cdd:COG1566    82 QAALAQAEAQLAAAEAqlARLEAELGAEAEIAAAEAQLAAAQAQLDL-AQRELERYQALYKK--GAVS-----QQELDEA 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  459 AKDQEAARQDHAQQLAIVAEAREA--SLRERDAARQQLETLEkekaAKLESLQQQLE 513
Cdd:COG1566   154 RAALDAAQAQLEAAQAQLAQAQAGlrEEEELAAAQAQVAQAE----AALAQAELNLA 206
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 952-1568 4.28e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 49.44  E-value: 4.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   952 LRGQEAAQRTELKE----LQQTLEHLK--TQLVKKEKEQH------------PAGSTGGEEASAPEAQLETVRKTEApdp 1013
Cdd:pfam10174   47 LRKEEAARISVLKEqyrvTQEENQHLQltIQALQDELRAQrdlnqllqqdftTSPVDGEDKFSTPELTEENFRRLQS--- 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1014 EVEALRAEVSKLEQQCQQQKQQVEGLTHSLESerasRAEQ-DKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKA 1092
Cdd:pfam10174  124 EHERQAKELFLLRKTLEEMELRIETQKQTLGA----RDESiKKLLEMLQSKGLPKKSGEEDWERTRRIAEAEMQLGHLEV 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1093 QDHSKAEEEWKAQVA-----RGQQEA----------ERKSSLISSLE-------EEVSILNRQ-VLEKEGESKELKRLVV 1149
Cdd:pfam10174  200 LLDQKEKENIHLREElhrrnQLQPDPaktkalqtviEMKDTKISSLErnirdleDEVQMLKTNgLLHTEDREEEIKQMEV 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1150 AESEkSQKLEERLRLLQVETAsssaRAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKF 1229
Cdd:pfam10174  280 YKSH-SKFMKNKIDQLKQELS----KKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1230 FQKEQALSALQ------LEHTSTQAlvSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLrAELMRAQRELGE-- 1301
Cdd:pfam10174  355 EEKESFLNKKTkqlqdlTEEKSTLA--GEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQL-AGLKERVKSLQTds 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1302 ------LGPLRQKVAEQERAAQQLRAEKASyaeqlsmlkkahgllaeENRGLGERANLGRQflevELDQAREKyVQELAA 1375
Cdd:pfam10174  432 sntdtaLTTLEEALSEKERIIERLKEQRER-----------------EDRERLEELESLKK----ENKDLKEK-VSALQP 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1376 VRTDAETHLAEMRQEAQSTTRELEVMTAKY---EGAKVKVLEERQRFQEERQKlTAQVEELSKKLTEYDQASKVQQQKLK 1452
Cdd:pfam10174  490 ELTEKESSLIDLKEHASSLASSGLKKDSKLkslEIAVEQKKEECSKLENQLKK-AHNAEEAVRTNPEINDRIRLLEQEVA 568

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1453 AFQAQGGESQQEVQRLQAQLNELQTQLSQKEQ---AAEHYKLQMEKAKTHYDAKKQQNQElQDQLRDLEQLQ----KENK 1525
Cdd:pfam10174  569 RYKEESGKAQAEVERLLGILREVENEKNDKDKkiaELESLTLRQMKEQNKKVANIKHGQQ-EMKKKGAQLLEearrREDN 647

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 344240178  1526 ELRAEAERLGRELQQAGLKTK-EAEQACRHLSAQVRSLEAQVAH 1568
Cdd:pfam10174  648 LADNSQQLQLEELMGALEKTRqELDATKARLSSTQQSLAEKDGH 691
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1419-1588 4.69e-05

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 48.13  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1419 FQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQmekakt 1498
Cdd:cd22656   112 LEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIARKEIKDLQ------ 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1499 hyDAKKQQNQELQDQLRD-LEQLQKENKELRAEaerlgrelqqagLKTKEAEQAC-RHLSAQVRSLEAQVAHAdqqLRDL 1576
Cdd:cd22656   186 --KELEKLNEEYAAKLKAkIDELKALIADDEAK------------LAAALRLIADlTAADTDLDNLLALIGPA---IPAL 248

                         170
                  ....*....|..
gi 344240178 1577 GKFQVATDALKS 1588
Cdd:cd22656   249 EKLQGAWQAIAT 260
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 442-667 4.74e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 48.79  E-value: 4.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   442 EQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREaslrERDAARQQLETLEKEKAAKLESLQQQLEAANEARDS 521
Cdd:pfam15709  317 EEDPSKALLEKREQEKASRDRLRAERAEMRRLEVERKRRE----QEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLR 392

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   522 VQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKvmQEKAQLQEQLLALEETLQi 601
Cdd:pfam15709  393 KQRLEEERQRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEK--QRQKELEMQLAEEQKRLM- 469

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178   602 tkGSLEEEKhrtadalAEQQRcvTKMEAESRSLMEQREQEQKALEQEKAGRKglEARLQQLEEARQ 667
Cdd:pfam15709  470 --EMAEEER-------LEYQR--QKQEAEEKARLEAEERRQKEEEAARLALE--EAMKQAQEQARQ 522
antiphage_ZorA_2 NF033915
anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel ...
 286-462 5.24e-05

anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.


Pssm-ID: 411476 [Multi-domain]  Cd Length: 383  Bit Score: 48.61  E-value: 5.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  286 SQQCESPAQEKGEVLGDALQlETLKQ-----EAAKLAAHNTQLQARIETLDCERSQQEAQLLaerghfeeekQQLASLIA 360
Cdd:NF033915  215 SKESKEALQELHERIGDRLQ-ESLNGmseamQTALTDALNNIMAPAIQTLVSTTSQQSTQVL----------ESLVGNFM 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  361 DLQSSISNlsQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQ 440
Cdd:NF033915  284 DGMTSAGR--EQGLQMQQAAADVNAAVSGMSERLNQLFNSLSEQQGRQMERAQQQSSTFETQLQRLSGSANERQAQLEQR 361

                         170       180
                  ....*....|....*....|..
gi 344240178  441 VEQLSSSLKLKEQQLEEAAKDQ 462
Cdd:NF033915  362 FEELMSGLTEQLQTQLGAAQQR 383
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
 366-474 5.47e-05

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 48.18  E-value: 5.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   366 ISNLSQAKEELEQA-SQAQGAQLTAQVASLTALNTTLQQQQDqeLASlkeqAKKEQAQMVQSL-QEQEQAAQGLRQQVEQ 443
Cdd:TIGR04320  249 IPNPPNSLAALQAKlATAQADLAAAQTALNTAQAALTSAQTA--YAA----AQAALATAQKELaNAQAQALQTAQNNLAT 322

                           90       100       110
                   ....*....|....*....|....*....|.
gi 344240178   444 LSSSLKLKEQQLEEAAKDQEAARQDHAQQLA 474
Cdd:TIGR04320  323 AQAALANAEARLAKAKEALANLNADLAKKQA 353
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 556-920 5.65e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.97  E-value: 5.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   556 QAQAHVTELEAQLKAEQQkvaEREKVMQEKAQLQEQLlALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAE-SRSL 634
Cdd:pfam17380  279 QHQKAVSERQQQEKFEKM---EQERLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERElERIR 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   635 MEQREQEQKALEQEKAGRKGLEAR-LQQLEEARQAETEALRRELaEATASQHRAESESEQLIREVESWQKRFEArQQEEA 713
Cdd:pfam17380  355 QEERKRELERIRQEEIAMEISRMReLERLQMERQQKNERVRQEL-EAARKVKILEEERQRKIQQQKVEMEQIRA-EQEEA 432

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   714 RysamiQEQLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSplaqlhtTLARALQQVKEKEVRAQKLADdlttlqekma 793
Cdd:pfam17380  433 R-----QREVRRLEEERAREMERVRLEEQERQQQVERLRQQE-------EERKRKKLELEKEKRDRKRAE---------- 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   794 stskvaaclktlvlkagEQQEMTSLELLKEppgagnKESNWLEEQRggpfsSPQAALKAMEQEAEQMGSELERLRVALMK 873
Cdd:pfam17380  491 -----------------EQRRKILEKELEE------RKQAMIEEER-----KRKLLEKEMEERQKAIYEEERRREAEEER 542

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178   874 SQGQQQEERGQQEREVARLTRERSQAQA---------DLAQEKAAKAELEVRLQNT 920
Cdd:pfam17380  543 RKQQEMEERRRIQEQMRKATEERSRLEAmereremmrQIVESEKARAEYEATTPIT 598
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 523-937 6.17e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 48.35  E-value: 6.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAhvtELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQIT 602
Cdd:pfam07888   33 QNRLEECLQERAELLQAQEAANRQREKEKERYKRDRE---QWERQRRELESRVAELKEELRQSREKHEELEEKYKELSAS 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   603 KGSLEEEKhrtaDALAEQQrcvtkmeAESRSLMEQREQEQKALEQEKAGRkglEARLQQLEEaRQAETEALRRElaeata 682
Cdd:pfam07888  110 SEELSEEK----DALLAQR-------AAHEARIRELEEDIKTLTQRVLER---ETELERMKE-RAKKAGAQRKE------ 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   683 sqhrAESESEQLireveswQKRFEARQQEEARYSAMIQEqlaaLKGDHEKAGQEAQEEAVEVhgegqigeqqsplaqlhT 762
Cdd:pfam07888  169 ----EEAERKQL-------QAKLQQTEEELRSLSKEFQE----LRNSLAQRDTQVLQLQDTI-----------------T 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   763 TLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAACLKTLVLKAGEQQEMTSLELLKEPPGAGN------KESNWLE 836
Cdd:pfam07888  217 TLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQltlqlaDASLALR 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   837 EQRGGPFSSPQAALKAMEQEAEQmgseLERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVR 916
Cdd:pfam07888  297 EGRARWAQERETLQQSAEADKDR----IEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKAS 372

                          410       420
                   ....*....|....*....|.
gi 344240178   917 LQNTLNEQRVEFAALQEALDH 937
Cdd:pfam07888  373 LRVAQKEKEQLQAEKQELLEY 393
PRK09039 PRK09039
peptidoglycan -binding protein;
349-515 6.21e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 48.04  E-value: 6.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  349 EEEKQQLASLIADLQSSISNLSQAKEELeqasQAQGAQLTAQVASLTALNTTLQQQQDqELASLKEQAKKEQAQMVQSLQ 428
Cdd:PRK09039   52 DSALDRLNSQIAELADLLSLERQGNQDL----QDSVANLRASLSAAEAERSRLQALLA-ELAGAGAAAEGRAGELAQELD 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  429 EQEQAAQGLRQQVEQLSsslklkeQQLeeaakdqEAARqdhaQQLAIVAEAREASlrerdaarqqlETLEKEKAAKLESL 508
Cdd:PRK09039  127 SEKQVSARALAQVELLN-------QQI-------AALR----RQLAALEAALDAS-----------EKRDRESQAKIADL 177


                  ....*..
gi 344240178  509 QQQLEAA 515
Cdd:PRK09039  178 GRRLNVA 184
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
 407-797 6.55e-05

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 461718 [Multi-domain]  Cd Length: 562  Bit Score: 48.49  E-value: 6.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   407 QELASLKEQAKKEQAQMVQSLQEQEQA-------------AQGLRQQVEQLSSSLKLKEQQLEEAAKDQE--AARqdhaQ 471
Cdd:pfam05701   49 EEIPEYKKQSEAAEAAKAQVLEELESTkrlieelklnlerAQTEEAQAKQDSELAKLRVEEMEQGIADEAsvAAK----A 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   472 QLAIVAEAREASLRERDAARQQLETLEKEKAAKLEslqQQLEAANEARDSVQTSVtQVQQEKAELSQKIEELHACIEAAH 551
Cdd:pfam05701  125 QLEVAKARHAAAVAELKSVKEELESLRKEYASLVS---ERDIAIKRAEEAVSASK-EIEKTVEELTIELIATKESLESAH 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   552 QEQRQAQAHvtELEAQLKAEQQKVA---EREKVMQEKAQLQEQLLA-------LEETLQITKGSLEEEKHRTADALAEQQ 621
Cdd:pfam05701  201 AAHLEAEEH--RIGAALAREQDKLNwekELKQAEEELQRLNQQLLSakdlkskLETASALLLDLKAELAAYMESKLKEEA 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   622 RCVTKMEAESRSLMEQREQEQKALEQ-----EKAGR-----KGLEARLQQLEEARQAETEALRRELAEATASQHRAESES 691
Cdd:pfam05701  279 DGEGNEKKTSTSIQAALASAKKELEEvkaniEKAKDevnclRVAAASLRSELEKEKAELASLRQREGMASIAVSSLEAEL 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   692 EQLIREVESWQKRFEARQQEEARYSAMIQEqlAALKGDHEKA-GQEAQEEAVEVHGEgqiGEQQSplAQLHTTLARaLQQ 770
Cdd:pfam05701  359 NRTKSEIALVQAKEKEAREKMVELPKQLQQ--AAQEAEEAKSlAQAAREELRKAKEE---AEQAK--AAASTVESR-LEA 430

                          410       420       430
                   ....*....|....*....|....*....|..
gi 344240178   771 VKeKEVRAQKLADDLTT-----LQEKMASTSK 797
Cdd:pfam05701  431 VL-KEIEAAKASEKLALaaikaLQESESSAES 461
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1362-1582 6.88e-05

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 48.53  E-value: 6.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1362 LDQAREKYvQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKY---EGAKVKVLEErQRFQEERQKLtAQVEELSKKLT 1438
Cdd:COG0497   153 LEELLEEY-REAYRAWRALKKELEELRADEAERARELDLLRFQLeelEAAALQPGEE-EELEEERRRL-SNAEKLREALQ 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1439 E------------YDQASKVQQ--QKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEH---------------- 1488
Cdd:COG0497   230 EalealsggeggaLDLLGQALRalERLAEYDPSLAELAERLESALIELEEAASELRRYLDSLEFdperleeveerlallr 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1489 -----YKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAglktkeaeqacRHLSAQvrSLE 1563
Cdd:COG0497   310 rlarkYGVTVEELLAYAEELRAELAELENSDERLEELEAELAEAEAELLEAAEKLSAA-----------RKKAAK--KLE 376

                         250       260
                  ....*....|....*....|...
gi 344240178 1564 AQVAhadQQLRDLG----KFQVA 1582
Cdd:COG0497   377 KAVT---AELADLGmpnaRFEVE 396
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1043-1239 7.37e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 48.51  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1043 LESERASRAEQDKALEtLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAeeewkaQVARGQQEAERKSSLISS 1122
Cdd:PRK10929  119 LEKSRQAQQEQDRARE-ISDSLSQLPQQQTEARRQLNEIERRLQTLGTPNTPLAQA------QLTALQAESAALKALVDE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1123 LE-EEVSILNRQvlekegeskELKRLVVAESEK-SQKLEERLRLLQVETASSSARAAE----RSSALREEVQSLREEVEK 1196
Cdd:PRK10929  192 LElAQLSANNRQ---------ELARLRSELAKKrSQQLDAYLQALRNQLNSQRQREAEraleSTELLAEQSGDLPKSIVA 262

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 344240178 1197 QRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSAL 1239
Cdd:PRK10929  263 QFKINRELSQALNQQAQRMDLIASQQRQAASQTLQVRQALNTL 305
mukB PRK04863
chromosome partition protein MukB;
894-1587 7.44e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.80  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  894 RERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAK----LRGQEAAQR--TELKELQ 967
Cdd:PRK04863  282 RVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLvqtaLRQQEKIERyqADLEELE 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  968 QTLEhlktqlvkkekEQHPAgstgGEEASapEAQLETVRKTEAPDPEVEALRAEVSKLEQQCQQQKqqveglTHSLESER 1047
Cdd:PRK04863  362 ERLE-----------EQNEV----VEEAD--EQQEENEARAEAAEEEVDELKSQLADYQQALDVQQ------TRAIQYQQ 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1048 ASRA-------------EQDKA---LETLQGQLEEKTQELGH-----SQAASASAQRELTA-LHAKAQDHSKAEEEWkaQ 1105
Cdd:PRK04863  419 AVQAlerakqlcglpdlTADNAedwLEEFQAKEQEATEELLSleqklSVAQAAHSQFEQAYqLVRKIAGEVSRSEAW--D 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1106 VARgqqeaerksSLISSLEEEVsILNRQVLEKEGESKELKRlvvaESEKSQKLEERLRLLQvetasssaRAAERSSALRE 1185
Cdd:PRK04863  497 VAR---------ELLRRLREQR-HLAEQLQQLRMRLSELEQ----RLRQQQRAERLLAEFC--------KRLGKNLDDED 554

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1186 EVQSLREEVEKQRvisENLRQELTSQAERAEELGQELKAWQEKFFQKEQ----------ALSALQL---EHTSTQALVSE 1252
Cdd:PRK04863  555 ELEQLQEELEARL---ESLSESVSEARERRMALRQQLEQLQARIQRLAArapawlaaqdALARLREqsgEEFEDSQDVTE 631

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1253 LLpAKHLCQQLQAEQAAAEKRHR-----EEIEQSKQAAGGLRAELMR-AQRELGEL--------------------GPLR 1306
Cdd:PRK04863  632 YM-QQLLERERELTVERDELAARkqaldEEIERLSQPGGSEDPRLNAlAERFGGVLlseiyddvsledapyfsalyGPAR 710

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1307 QK--VAEQERAAQQLRA-------------------EKASYAEQLsmlkkAHGLLAEENrglgERANLGRQFLEVEL--D 1363
Cdd:PRK04863  711 HAivVPDLSDAAEQLAGledcpedlyliegdpdsfdDSVFSVEEL-----EKAVVVKIA----DRQWRYSRFPEVPLfgR 781

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1364 QAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQrfQEERQKLTAQVEELSKKLTeyDQA 1443
Cdd:PRK04863  782 AAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFIGSHLAVAFEADP--EAELRQLNRRRVELERALA--DHE 857

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1444 SKVQQQKLKAFQAQggESQQEVQRLQAQLN------------ELQTQLSQKEQAA----EHYKL--QMEKA-------KT 1498
Cdd:PRK04863  858 SQEQQQRSQLEQAK--EGLSALNRLLPRLNlladetladrveEIREQLDEAEEAKrfvqQHGNAlaQLEPIvsvlqsdPE 935

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1499 HYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGL------------KTKEAEQACRHLSAQVRSLEAQV 1566
Cdd:PRK04863  936 QFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLaknsdlneklrqRLEQAEQERTRAREQLRQAQAQL 1015

                         810       820
                  ....*....|....*....|..
gi 344240178 1567 AHADQQLRDL-GKFQVATDALK 1587
Cdd:PRK04863 1016 AQYNQVLASLkSSYDAKRQMLQ 1037
mukB PRK04863
chromosome partition protein MukB;
138-443 7.90e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.80  E-value: 7.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  138 KDAQIAMMQQRIDHLAllnEKQAASSQESRELEelrgknesltvRLHETLKQC-----------------QNLKTEKNQM 200
Cdd:PRK04863  784 REKRIEQLRAEREELA---ERYATLSFDVQKLQ-----------RLHQAFSRFigshlavafeadpeaelRQLNRRRVEL 849

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  201 DRKISQLSEENGDLSFKV---REFASHLQQLQGAFNDLTEEHnkasqeWAEKQTHLEKELSTALQDKKYLEEKneilQGK 277
Cdd:PRK04863  850 ERALADHESQEQQQRSQLeqaKEGLSALNRLLPRLNLLADET------LADRVEEIREQLDEAEEAKRFVQQH----GNA 919

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  278 LSQLEERASQQCESP---AQEKGEVLGDALQLETLKQEA----------------------AKLAAHNTQLQARIETLDC 332
Cdd:PRK04863  920 LAQLEPIVSVLQSDPeqfEQLKQDYQQAQQTQRDAKQQAfaltevvqrrahfsyedaaemlAKNSDLNEKLRQRLEQAEQ 999

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  333 ERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEEL-----------EQASQAQGAQLTAQVASLTALNTTL 401
Cdd:PRK04863 1000 ERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELqdlgvpadsgaEERARARRDELHARLSANRSRRNQL 1079

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 344240178  402 QQQQDQELASLKEQAKKeqaqmvqsLQEQEQAAQGLRQQVEQ 443
Cdd:PRK04863 1080 EKQLTFCEAEMDNLTKK--------LRKLERDYHEMREQVVN 1113
mukB PRK04863
chromosome partition protein MukB;
941-1576 8.38e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.41  E-value: 8.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  941 EKEGKDQELAKLRGQEAAQRTELKELQQTLehlkTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRkteapdpevEALRA 1020
Cdd:PRK04863  280 ERRVHLEEALELRRELYTSRRQLAAEQYRL----VEMARELAELNEAESDLEQDYQAASDHLNLVQ---------TALRQ 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1021 EvSKLEQQCQQqkqqVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKA---QDHSK 1097
Cdd:PRK04863  347 Q-EKIERYQAD----LEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAiqyQQAVQ 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1098 AEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKE-------------GESKELKRLVVAESEKSQ------KL 1158
Cdd:PRK04863  422 ALERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEqklsvaqaahsqfEQAYQLVRKIAGEVSRSEawdvarEL 501

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1159 EERLRLLQVETASSSA-----RAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKE 1233
Cdd:PRK04863  502 LRRLREQRHLAEQLQQlrmrlSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERR 581

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1234 QALSALQLEhtsTQALVSELlpakhlcqqlqaeqaaaeKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQE 1313
Cdd:PRK04863  582 MALRQQLEQ---LQARIQRL------------------AARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERE 640

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1314 RAAQQ----LRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN---LGRQFLEVELDQAreKYVQEL------AAVRTD- 1379
Cdd:PRK04863  641 RELTVerdeLAARKQALDEEIERLSQPGGSEDPRLNALAERFGgvlLSEIYDDVSLEDA--PYFSALygparhAIVVPDl 718

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1380 --AETHLAEMR-------------QEAQSTTRELEVMtakyEGAKVKVLEERQ----RFQEE-------RQKLTAQV-EE 1432
Cdd:PRK04863  719 sdAAEQLAGLEdcpedlyliegdpDSFDDSVFSVEEL----EKAVVVKIADRQwrysRFPEVplfgraaREKRIEQLrAE 794

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1433 LSKKLTEYDQAS----KVQQ--QKLKAFQAQ------GGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHY 1500
Cdd:PRK04863  795 REELAERYATLSfdvqKLQRlhQAFSRFIGShlavafEADPEAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGL 874

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1501 dakkQQNQELQDQLRDL--EQLQKENKELRAE---AERLGRELQQAGLKTKEAEQ---ACRHLSAQVRSLEAQVAHADQQ 1572
Cdd:PRK04863  875 ----SALNRLLPRLNLLadETLADRVEEIREQldeAEEAKRFVQQHGNALAQLEPivsVLQSDPEQFEQLKQDYQQAQQT 950


                  ....
gi 344240178 1573 LRDL 1576
Cdd:PRK04863  951 QRDA 954
PRK09039 PRK09039
peptidoglycan -binding protein;
420-580 8.58e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 47.65  E-value: 8.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  420 QAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQqleeaakdqeaarqdHAQQLAIVAEAREASLRERDAARQQLETLEK 499
Cdd:PRK09039   41 QFFLSREISGKDSALDRLNSQIAELADLLSLERQ---------------GNQDLQDSVANLRASLSAAEAERSRLQALLA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  500 EKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEEL-------HACIEAAHQEQRQAQAHVTELEAQLK-AE 571
Cdd:PRK09039  106 ELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELLNQQIAALrrqlaalEAALDASEKRDRESQAKIADLGRRLNvAL 185


                  ....*....
gi 344240178  572 QQKVAEREK 580
Cdd:PRK09039  186 AQRVQELNR 194
Caldesmon pfam02029
Caldesmon;
429-739 9.33e-05

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 47.94  E-value: 9.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   429 EQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKL-ES 507
Cdd:pfam02029    3 DEEEAARERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLqEA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   508 LQQQLE---AANEARDSVQTSVTQVQQEKAELSQKieelHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQE 584
Cdd:pfam02029   83 LERQKEfdpTIADEKESVAERKENNEEEENSSWEK----EEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   585 KAQLQEQLLALE------ETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQ---------KALEQEK 649
Cdd:pfam02029  159 EEDKSEEAEEVPtenfakEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTtkrrqgglsQSQEREE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   650 AGRKGLEARlQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEA----RQQEEARYSAMIQEQLAA 725
Cdd:pfam02029  239 EAEVFLEAE-QKLEELRRRRQEKESEEFEKLRQKQQEAELELEELKKKREERRKLLEEeeqrRKQEEAERKLREEEEKRR 317

                          330
                   ....*....|....
gi 344240178   726 LKGDHEKAGQEAQE 739
Cdd:pfam02029  318 MKEEIERRRAEAAE 331
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1194-1550 9.48e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.20  E-value: 9.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1194 VEKQRVISENLRQELTS--QAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSEllPAKHLCQQLQAEQAAAE 1271
Cdd:pfam17380  278 VQHQKAVSERQQQEKFEkmEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAE--QERMAMERERELERIRQ 355

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1272 KRHREEIEQSKQAAGGLRAELMRaqrELGELGPLRQKvaEQERAAQQLRAekasyaeqlsmlKKAHGLLAEENRGLGERA 1351
Cdd:pfam17380  356 EERKRELERIRQEEIAMEISRMR---ELERLQMERQQ--KNERVRQELEA------------ARKVKILEEERQRKIQQQ 418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1352 NLGRQFLEVELDQAREKYVQELAAVRtdaETHLAEMRQEAQSTTRELEVMtakyegakvkvleERQRFQEERQKLTAQVE 1431
Cdd:pfam17380  419 KVEMEQIRAEQEEARQREVRRLEEER---AREMERVRLEEQERQQQVERL-------------RQQEEERKRKKLELEKE 482

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1432 ELSKKLTEyDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHyklqmekakthyDAKKQQNQELQ 1511
Cdd:pfam17380  483 KRDRKRAE-EQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREA------------EEERRKQQEME 549

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 344240178  1512 DQLRDLEQLQKENKEL-RAEAERLGRELQQAGLKTKEAEQ 1550
Cdd:pfam17380  550 ERRRIQEQMRKATEERsRLEAMEREREMMRQIVESEKARA 589
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 401-791 9.81e-05

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 47.75  E-value: 9.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   401 LQQQQDQELASLKE-----QAKKEQ--AQMVQSLQEQEQAAQglrqQVEQLSSSL-KLKEQQLEEAAK---------DQE 463
Cdd:pfam15070    9 LQTERDQYAENLKEegavwQQKMQQlsEQVRTLREEKERSVS----QVQELETSLaELKNQAAVPPAEeeqppagpsEEE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   464 AARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKA--------- 534
Cdd:pfam15070   85 QRLQEEAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILEDMQSDRAtisralsqn 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   535 -ELSQKIEELHACIEAAHQEQrqaqahvTELEAQLKAEQQKVAEREKVMqekAQLQEQLLALEETLqitkgsleEEKHRT 613
Cdd:pfam15070  165 rELKEQLAELQNGFVKLTNEN-------MELTSALQSEQHVKKELAKKL---GQLQEELGELKETL--------ELKSQE 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   614 ADALAEQQ-RCVTKME---AESRSLMEQREQEQKALEQEKAgrkgLEARLQQLEEARQAETEALRRELAEAtasqhraes 689
Cdd:pfam15070  227 AQSLQEQRdQYLAHLQqyvAAYQQLASEKEELHKQYLLQTQ----LMDRLQHEEVQGKVAAEMARQELQET--------- 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   690 eseqlireveswQKRFEARQQEEARYSAMIQEQLAALKGDhEKAGQEAQEEAVEV---------HGEGQIGEQQSPLAQL 760
Cdd:pfam15070  294 ------------QERLEALTQQNQQLQAQLSLLANPGEGD-GLESEEEEEEAPRPslsipedfeSREAMVAFFNSALAQA 360

                          410       420       430
                   ....*....|....*....|....*....|.
gi 344240178   761 HTTLARALQQVKEKEVRAQKLADDLTTLQEK 791
Cdd:pfam15070  361 EEERAELRRQLKEQKRRCRRLAQQAAPAQEE 391
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 521-1160 1.00e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 48.20  E-value: 1.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   521 SVQTSVTQVQQEKA--ELSQKIE--ELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALE 596
Cdd:pfam05557    6 ESKARLSQLQNEKKqmELEHKRAriELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   597 ETLqitkGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKagrKGLEARLqQLEEARQAETEALRRE 676
Cdd:pfam05557   86 EAL----NKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEL---EELQERL-DLLKAKASEAEQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   677 LAEATASQHRAESESEQLIREV---ESWQKRFEARQQEEARYSAMIQE---------QLAALKGD-----HEKAGQEAQE 739
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKELEFEIqsqEQDSEIVKNSKSELARIPELEKElerlrehnkHLNENIENklllkEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   740 EAVEvhgegqigEQQSPLAQLHTTLARALQQVKEKEVRAQklaDDLTTLQEKMASTSKVAACLktlvlkageQQEMTsle 819
Cdd:pfam05557  238 EREE--------KYREEAATLELEKEKLEQELQSWVKLAQ---DTGLNLRSPEDLSRRIEQLQ---------QREIV--- 294

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   820 lLKEPPGAGNKESNWLEEQRggpfsspqaalKAMEQEAEQMGSELERLRVAlmksqgqqqeergqqerevarltRERSQA 899
Cdd:pfam05557  295 -LKEENSSLTSSARQLEKAR-----------RELEQELAQYLKKIEDLNKK-----------------------LKRHKA 339

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   900 QADLAQEKAAkaelevrlqnTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRgqEAAQRTElkELQQTLEHLKTQLVK 979
Cdd:pfam05557  340 LVRRLQRRVL----------LLTKERDGYRAILESYDKELTMSNYSPQLLERIE--EAEDMTQ--KMQAHNEEMEAQLSV 405

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   980 KEKEQhpagSTGGEEASAPEAQLETVRKTEAPDpEVEALRAEVSKLEQQCQqqkqqveglthSLESERASRAEQDKALET 1059
Cdd:pfam05557  406 AEEEL----GGYKQQAQTLERELQALRQQESLA-DPSYSKEEVDSLRRKLE-----------TLELERQRLREQKNELEM 469

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1060 lqgqleektqELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLE---EEVSILNRQVLE 1136
Cdd:pfam05557  470 ----------ELERRCLQGDYDPKKTKVLHLSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLEddlEQVLRLPETTST 539

                          650       660
                   ....*....|....*....|....*
gi 344240178  1137 -KEGESKELKRLVVAESEKSQKLEE 1160
Cdd:pfam05557  540 mNFKEVLDLRKELESAELKNQRLKE 564
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1395-1540 1.09e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 46.93  E-value: 1.09e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   1395 TRELEVMTAKYEgakvKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQK----LKAFQAQGGESQQEVQRLQA 1470
Cdd:smart00787  150 DENLEGLKEDYK----LLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCdpteLDRAKEKLKKLLQEIMIKVK 225

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178   1471 QLNELQTQLSQKEQAAEhyklqmekakthydAKKQQNQELQDQLRDLEQLQKENKELRA-EAERLGRELQQ 1540
Cdd:smart00787  226 KLEELEEELQELESKIE--------------DLTNKKSELNTEIAEAEKKLEQCRGFTFkEIEKLKEQLKL 282
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 1455-1593 1.09e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 48.02  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1455 QAQGGESQQEVQRLQAQLNELQtqlSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEA-ER 1533
Cdd:PRK11448  141 ENLLHALQQEVLTLKQQLELQA---REKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSQERkQK 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178 1534 LGRELQQAGLKTKEAEQACRHLsaqvrsleaqvahADQQLRDLGkFQVATDAL---KSREPQK 1593
Cdd:PRK11448  218 RKEITDQAAKRLELSEEETRIL-------------IDQQLRKAG-WEADSKTLrfsKGARPEK 266
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
844-1387 1.15e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  844 SSPQAALKAM-EQEAEQMGSELERLRVALMKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVRLQNTln 922
Cdd:COG4717    37 STLLAFIRAMlLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL-- 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  923 EQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQL 1002
Cdd:COG4717   115 REELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEEL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1003 ETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLEserasRAEQDKALETLQGQLEEKTQELGhsqAASAsaq 1082
Cdd:COG4717   195 QDLAE------ELEELQQRLAELEEELEEAQEELEELEEELE-----QLENELEAAALEERLKEARLLLL---IAAA--- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1083 reLTALHAKAQDHSKAEEEWKAQVArgqqeaerksSLISSLEEEVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERL 1162
Cdd:COG4717   258 --LLALLGLGGSLLSLILTIAGVLF----------LVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELL 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1163 RLLQVETASSSARAAERSSALREEVQSLREEVEKQRVIS-ENLRQELTS-----QAERAEELGQELKAWQEkFFQKEQAL 1236
Cdd:COG4717   326 AALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEELEQEIAAllaeaGVEDEEELRAALEQAEE-YQELKEEL 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1237 SALQLEHTSTQALVSELLPAkhlcqqlqaeqaAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGpLRQKVAEQERAA 1316
Cdd:COG4717   405 EELEEQLEELLGELEELLEA------------LDEEELEEELEELEEELEELEEELEELREELAELE-AELEQLEEDGEL 471

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178 1317 QQLRAEKASYAEQLSMLKKAHGllaeenrglgeRANLGRQFLEVELDQAREKYvqeLAAVRTDAETHLAEM 1387
Cdd:COG4717   472 AELLQELEELKAELRELAEEWA-----------ALKLALELLEEAREEYREER---LPPVLERASEYFSRL 528
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
484-744 1.17e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.83  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  484 LRERDAARQQLETLEKekaaKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTE 563
Cdd:COG1340    14 EEKIEELREEIEELKE----KRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  564 LEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKH------------RTADALAEQQRCVTKMEAES 631
Cdd:COG1340    90 LREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKElvekikelekelEKAKKALEKNEKLKELRAEL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  632 RSLMEQREQEQKALEQ--EKAGRKglearLQQLEEARQaETEALRRELAEATAS----QHRAESESEQLIreveswQKRF 705
Cdd:COG1340   170 KELRKEAEEIHKKIKElaEEAQEL-----HEEMIELYK-EADELRKEADELHKEiveaQEKADELHEEII------ELQK 237

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 344240178  706 EARQQEEArYSAMIQEQLAALKgdhEKAGQEAQEEAVEV 744
Cdd:COG1340   238 ELRELRKE-LKKLRKKQRALKR---EKEKEELEEKAEEI 272
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1414-1541 1.18e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1414 EERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGE--SQQEVQRLQAQLNELQTQLSQKEQAAEHYKL 1491
Cdd:COG1579    38 DELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNvrNNKEYEALQKEIESLKRRISDLEDEILELME 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 344240178 1492 QMEKAKTHYDAKKQQNQELQDqlrDLEQLQKENKELRAEAERLGRELQQA 1541
Cdd:COG1579   118 RIEELEEELAELEAELAELEA---ELEEKKAELDEELAELEAELEELEAE 164
Filament pfam00038
Intermediate filament protein;
1305-1541 1.20e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 46.84  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1305 LRQKVAE-QERAAQQLRAEKASYAEQLSMLKKAHGLLAEENrglgERANLGRQFLEVELDQAREKYVQELAaVRTDAETH 1383
Cdd:pfam00038   30 LETKISElRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVER----ARLQLELDNLRLAAEDFRQKYEDELN-LRTSAEND 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1384 LAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE--------------ELSKKLTEY-----DQAS 1444
Cdd:pfam00038  105 LVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdtqvnvemdaarklDLTSALAEIraqyeEIAA 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1445 KVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQkeqaaehYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQ-LQKE 1523
Cdd:pfam00038  185 KNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITE-------LRRTIQSLEIELQSLKKQKASLERQLAETEErYELQ 257

                          250
                   ....*....|....*...
gi 344240178  1524 NKELRAEAERLGRELQQA 1541
Cdd:pfam00038  258 LADYQELISELEAELQET 275
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 349-587 1.21e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  349 EEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQdQELASLKEQAKKeqaqMVQSLQ 428
Cdd:COG3883    22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE-AEIEERREELGE----RARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  429 EQEQAAQGLrqqvEQLSSSlklkeQQLEEAAKDQEAARQDHAQQLAIVAEARE--ASLRERDAARQQLETLEKEKAAKLE 506
Cdd:COG3883    97 RSGGSVSYL----DVLLGS-----ESFSDFLDRLSALSKIADADADLLEELKAdkAELEAKKAELEAKLAELEALKAELE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  507 SLQQQLEAAneardsvqtsVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKA 586
Cdd:COG3883   168 AAKAELEAQ----------QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237


                  .
gi 344240178  587 Q 587
Cdd:COG3883   238 A 238
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 921-1101 1.39e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  921 LNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEKeqhpagstggeeasapea 1000
Cdd:COG1579    19 LDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEE------------------ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1001 QLETVRKTEapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELghsQAASAS 1080
Cdd:COG1579    81 QLGNVRNNK----EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAEL---DEELAE 153

                         170       180
                  ....*....|....*....|.
gi 344240178 1081 AQRELTALHAKAQDHSKAEEE 1101
Cdd:COG1579   154 LEAELEELEAEREELAAKIPP 174
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
250-458 1.49e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  250 QTHLEKELSTALQDKKYLEEKNEILQGKLSQLEE-----RASQQCESPAQEKGEVLGdalQLETLKQEAAKLAAHNTQLQ 324
Cdd:COG3206   163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAaleefRQKNGLVDLSEEAKLLLQ---QLSELESQLAEARAELAEAE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  325 ARIETLD--CERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLS-------QAKEELEQASQAQGAQLTAQVASLT 395
Cdd:COG3206   240 ARLAALRaqLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTpnhpdviALRAQIAALRAQLQQEAQRILASLE 319

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178  396 ALNTTLQQQQdQELASLKEQAKKEqaqmVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEA 458
Cdd:COG3206   320 AELEALQARE-ASLQAQLAQLEAR----LAELPELEAELRRLEREVEVARELYESLLQRLEEA 377
Filament pfam00038
Intermediate filament protein;
948-1197 1.63e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 46.45  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   948 ELAKLRGQEAAQRTELKEL-QQTLEHLKTQLVkkekeqhpagSTGGEEASApEAQLETVRKteapdpEVEALRAEVSKLE 1026
Cdd:pfam00038   33 KISELRQKKGAEPSRLYSLyEKEIEDLRRQLD----------TLTVERARL-QLELDNLRL------AAEDFRQKYEDEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1027 QQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQL--------EEKTQELGHSQAAS-------------ASAQREL 1085
Cdd:pfam00038   96 NLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELaflkknheEEVRELQAQVSDTQvnvemdaarkldlTSALAEI 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1086 TALHAKAQDHSK--AEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGEskelkrlvvAESEKSQK--LEER 1161
Cdd:pfam00038  176 RAQYEEIAAKNReeAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE---------LQSLKKQKasLERQ 246

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 344240178  1162 LRLLQVETASSSARAAERSSALREEVQSLREEVEKQ 1197
Cdd:pfam00038  247 LAETEERYELQLADYQELISELEAELQETRQEMARQ 282
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
253-612 1.65e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.82  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  253 LEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLdc 332
Cdd:COG4372    29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL-- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  333 ersqqeaqllaerghfEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASL 412
Cdd:COG4372   107 ----------------QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  413 KEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRErDAARQ 492
Cdd:COG4372   171 QELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALEL-EEDKE 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  493 QLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQ 572
Cdd:COG4372   250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 344240178  573 QKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHR 612
Cdd:COG4372   330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1272-1455 1.69e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1272 KRHREEIEQSKQAAGGLRAELMRAQRELGELgplRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAeenrglgera 1351
Cdd:COG1579    27 KELPAELAELEDELAALEARLEAAKTELEDL---EKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEA---------- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1352 nlgrqfLEVELDQAREKyvqelaavRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVE 1431
Cdd:COG1579    94 ------LQKEIESLKRR--------ISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159

                         170       180
                  ....*....|....*....|....
gi 344240178 1432 ELSKKLTEYdqASKVQQQKLKAFQ 1455
Cdd:COG1579   160 ELEAEREEL--AAKIPPELLALYE 181
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1059-1530 1.76e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1059 TLQGQLEEKTQELGHSQAASASAQRELTALhakaqdhSKAEEEWKAQVARGQQEAERKSSLISSLEE-------EVSILN 1131
Cdd:TIGR04523  229 QLKDNIEKKQQEINEKTTEISNTQTQLNQL-------KDEQNKIKKQLSEKQKELEQNNKKIKELEKqlnqlksEISDLN 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1132 RQvlEKEGESKELKrlvvaesEKSQKLEERLRLLQVETASSSaraaERSSALREEVQSLREEVEKqrviSENLRQELTSQ 1211
Cdd:TIGR04523  302 NQ--KEQDWNKELK-------SELKNQEKKLEEIQNQISQNN----KIISQLNEQISQLKKELTN----SESENSEKQRE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1212 AERAEELGQELKAWQEKFFQKEQALSalqlehTSTQALVSELlpakhlcqqlqaeqaaaekRHREEIEQSKQaagglrae 1291
Cdd:TIGR04523  365 LEEKQNEIEKLKKENQSYKQEIKNLE------SQINDLESKI-------------------QNQEKLNQQKD-------- 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1292 lmraqrelGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKahgllaeenrglgERANLGRQFLEVE-LDQAREKYV 1370
Cdd:TIGR04523  412 --------EQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTN-------------QDSVKELIIKNLDnTRESLETQL 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1371 QELAAVRTDAETHLAEMRQEAQSTTRELEVMTA--KYEGAKVKVLEERQR-FQEERQKLTAQVEELSKKLTEYDQASKVQ 1447
Cdd:TIGR04523  471 KVLSRSINKIKQNLEQKQKELKSKEKELKKLNEekKELEEKVKDLTKKISsLKEKIEKLESEKKEKESKISDLEDELNKD 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1448 QQKLKAFQAQGgesqqEVQRLQAQLNEL-QTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ--NQELQDQL-RDLEQLQKE 1523
Cdd:TIGR04523  551 DFELKKENLEK-----EIDEKNKEIEELkQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIeeKEKKISSLeKELEKAKKE 625


                   ....*..
gi 344240178  1524 NKELRAE 1530
Cdd:TIGR04523  626 NEKLSSI 632
HpsJ_fam NF038305
HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the ...
 397-512 1.79e-04

HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the biosynthesis or secretion of an extracellular polysaccharide shared by many Cyanobacteria.


Pssm-ID: 468465 [Multi-domain]  Cd Length: 230  Bit Score: 45.65  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  397 LNTTlQQQQDQELASLKEQAKKEQAQmVQSLQEQEQAAQGlRQQVEQLSSSLKLKEQQLEEAAKDQEaARQDHAQQLAIV 476
Cdd:NF038305   99 LNNT-RRLSTQALQQINQQAGQQETQ-LQQQLNQLQAQTS-PQQLNQLLKSEQKQGQALASGQLPEE-QKEQLQQFKSNP 174

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 344240178  477 AEAREASLRERDAARQQLETLEKEkaAKLESLQQQL 512
Cdd:NF038305  175 QALDKFLAQQLTQIRTQAEEAEKQ--ARLEALKSSL 208
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 403-725 1.80e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.45  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   403 QQQDQELASLKEQAKkeQAQMVQSLQEQEQAAQGLRQQveqlssslkLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREA 482
Cdd:pfam13868    2 RENSDELRELNSKLL--AAKCNKERDAQIAEKKRIKAE---------EKEEERRLDEMMEEERERALEEEEEKEEERKEE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   483 SLRERDAARQQLETLEKEKaakleslQQQLEAANEARDSVQTSVTQVQQEKAELSQKieelhacieaAHQEQRQAQAHVT 562
Cdd:pfam13868   71 RKRYRQELEEQIEEREQKR-------QEEYEEKLQEREQMDEIVERIQEEDQAEAEE----------KLEKQRQLREEID 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   563 ELEAQLKAEQQKVAEREKVMQEK-AQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQE 641
Cdd:pfam13868  134 EFNEEQAEWKELEKEEEREEDERiLEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDEKAERDELRAKLYQE 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   642 QKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREveswQKRFEARQQEEARYSAMIQE 721
Cdd:pfam13868  214 EQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRK----QAEDEEIEQEEAEKRRMKRL 289


                   ....
gi 344240178   722 QLAA 725
Cdd:pfam13868  290 EHRR 293
PRK10920 PRK10920
putative uroporphyrinogen III C-methyltransferase; Provisional
 390-455 2.17e-04

putative uroporphyrinogen III C-methyltransferase; Provisional


Pssm-ID: 236795  Cd Length: 390  Bit Score: 46.63  E-value: 2.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  390 QVASLTALNTTLQQQqdqeLASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQL 455
Cdd:PRK10920   61 QAQNQTATNDALANQ----LTALQKAQESQKQELEGILKQQAKALDQANRQQAALAKQLDELQQKV 122
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
434-699 2.33e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 46.61  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  434 AQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDaarqqLETLEKEKA--AKLESLQQQ 511
Cdd:COG0497   153 LEELLEEYREAYRAWRALKKELEELRADEAERARELDLLRFQLEELEAAALQPGE-----EEELEEERRrlSNAEKLREA 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  512 LEAANEARDSVQTSV-TQVQQEKAELsQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQE 590
Cdd:COG0497   228 LQEALEALSGGEGGAlDLLGQALRAL-ERLAEYDPSLAELAERLESALIELEEAASELRRYLDSLEFDP---ERLEEVEE 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  591 QLLALEETLQitkgsleeeKHR-TADALAEqqrcvtkmeaesrsLMEQREQEQKALEqekagrkGLEARLQQLEEARQAE 669
Cdd:COG0497   304 RLALLRRLAR---------KYGvTVEELLA--------------YAEELRAELAELE-------NSDERLEELEAELAEA 353

                         250       260       270
                  ....*....|....*....|....*....|
gi 344240178  670 TEALrRELAEAtASQHRAESeSEQLIREVE 699
Cdd:COG0497   354 EAEL-LEAAEK-LSAARKKA-AKKLEKAVT 380
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 303-600 2.38e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.07  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   303 ALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQA 382
Cdd:pfam13868   51 EERERALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLRE 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   383 QGAQLTAQVASLTALNttlQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSsslklkeqQLEEAAKDQ 462
Cdd:pfam13868  131 EIDEFNEEQAEWKELE---KEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLR--------AQQEKAQDE 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   463 EAARQDHAQQLAIVAEAREASLRERDAARQQLEtlekEKAAKLESLQQQLEAANEARDsvqtsvTQVQQEKAELSQKIEE 542
Cdd:pfam13868  200 KAERDELRAKLYQEEQERKERQKEREEAEKKAR----QRQELQQAREEQIELKERRLA------EEAEREEEEFERMLRK 269

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178   543 LHACIE----AAHQEQRQAQAHVTELEAQLKA-EQQKVAEREKVMQEKAQLQEQLLALEETLQ 600
Cdd:pfam13868  270 QAEDEEieqeEAEKRRMKRLEHRRELEKQIEErEEQRAAEREEELEEGERLREEEAERRERIE 332
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
99-600 2.61e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 46.55  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   99 ILQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAASSQESRELEELRGKNES 178
Cdd:COG0840     1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  179 LTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEWAEKQTHLEKELS 258
Cdd:COG0840    81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  259 TALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQEKGEVLGDALQ--LETLKQEAAKLAAHNtqLQARIETldceRSQ 336
Cdd:COG0840   161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITrpLRELLEVLERIAEGD--LTVRIDV----DSK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  337 QEAQLLAErgHFEEEKQQLASLIADLQSSISNLSQAKEELEQAS-------QAQGAQLTAQVASLTALNTTLQQ--QQDQ 407
Cdd:COG0840   235 DEIGQLAD--AFNRMIENLRELVGQVRESAEQVASASEELAASAeelaagaEEQAASLEETAAAMEELSATVQEvaENAQ 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  408 ELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLklkeQQLEEAAK-------------DQ----------EA 464
Cdd:COG0840   313 QAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETI----EELGESSQeigeivdviddiaEQtnllalnaaiEA 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  465 ARQ-DHAQQLAIVA-EAREASLRERDAArqqletleKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEE 542
Cdd:COG0840   389 ARAgEAGRGFAVVAdEVRKLAERSAEAT--------KEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEE 460

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  543 LHACIE----------AAHQEQRQAQAHVTELEAQLKAE-QQKVAEREKVMQEKAQLQEQLLALEETLQ 600
Cdd:COG0840   461 IVEAVEevsdliqeiaAASEEQSAGTEEVNQAIEQIAAAaQENAASVEEVAAAAEELAELAEELQELVS 529
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 226-551 2.77e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 46.97  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  226 QQLQGAFNDLTEehNKASQEWAEK-QTHLEK--ELSTALQDKKYLEEKN---------------EILQGKlSQLEERASQ 287
Cdd:PRK10929   48 EALQSALNWLEE--RKGSLERAKQyQQVIDNfpKLSAELRQQLNNERDEprsvppnmstdaleqEILQVS-SQLLEKSRQ 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  288 -QCEspaQEKGEVLGDALQLETLKQEAAKLA--------------------AHNTQLQA-------RIETLDCER-SQQE 338
Cdd:PRK10929  125 aQQE---QDRAREISDSLSQLPQQQTEARRQlneierrlqtlgtpntplaqAQLTALQAesaalkaLVDELELAQlSANN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  339 AQLLAeRGHFEEEKQQLASLIADLQSSISNL-SQAKEELEQAsQAQGAQLTAQVASLTAlNTTLQQQQDQELAslkeQAK 417
Cdd:PRK10929  202 RQELA-RLRSELAKKRSQQLDAYLQALRNQLnSQRQREAERA-LESTELLAEQSGDLPK-SIVAQFKINRELS----QAL 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  418 KEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHA--------QQL-AIVAEAREASLRERD 488
Cdd:PRK10929  275 NQQAQRMDLIASQQRQAASQTLQVRQALNTLREQSQWLGVSNALGEALRAQVArlpempkpQQLdTEMAQLRVQRLRYED 354

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178  489 --AARQQLETLEKEKAAKLESLQQ-----QLEAANEARDSV----QTSVTQVQQEKAELSQKIEELHACIEAAH 551
Cdd:PRK10929  355 llNKQPQLRQIRQADGQPLTAEQNrildaQLRTQRELLNSLlsggDTLILELTKLKVANSQLEDALKEVNEATH 428
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
571-790 2.82e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  571 EQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEE--EKHRTADAlaeqqrcvtkmEAESRSLMEQREQEQKALEQE 648
Cdd:COG3206   163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEfrQKNGLVDL-----------SEEAKLLLQQLSELESQLAEA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  649 KAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAEseseqlIREVEswQKRFEARQQEEARYSAMI--QEQLAAL 726
Cdd:COG3206   232 RAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQ------LAELE--AELAELSARYTPNHPDVIalRAQIAAL 303

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  727 KgdhEKAGQEAQEEAVEVHGEGQIGEQQspLAQLHTTLARALQQVK---EKEVRAQKLADDLTTLQE 790
Cdd:COG3206   304 R---AQLQQEAQRILASLEAELEALQAR--EASLQAQLAQLEARLAelpELEAELRRLEREVEVARE 365
PRK09039 PRK09039
peptidoglycan -binding protein;
1420-1541 2.89e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 45.73  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1420 QEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNEL-------QTQLSQKEQAAEHYKLQ 1492
Cdd:PRK09039   52 DSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELagagaaaEGRAGELAQELDSEKQV 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 344240178 1493 MEKAKTHYDAKKQQNQELQDQLRDLEQL----QKENKELRAEAERLGRELQQA 1541
Cdd:PRK09039  132 SARALAQVELLNQQIAALRRQLAALEAAldasEKRDRESQAKIADLGRRLNVA 184
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1424-1576 3.02e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1424 QKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKThydak 1503
Cdd:COG1579    13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRN----- 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178 1504 kqqNQELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQAC----RHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:COG1579    88 ---NKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELaeleAELEEKKAELDEELAELEAELEEL 161
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 154-480 3.07e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.64  E-value: 3.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   154 LLNEKQaassQESRELEELRGKNESLTVRLHETLKQCQNL-------KTEKNQMDRKISQLSEENGDLSFKVREFASHLQ 226
Cdd:pfam05483  420 LLDEKK----QFEKIAEELKGKEQELIFLLQAREKEIHDLeiqltaiKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCD 495

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   227 QLQGAFNDLTEEHNKASQEWAEKQTHL---EKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPA--QEKGEVLG 301
Cdd:pfam05483  496 KLLLENKELTQEASDMTLELKKHQEDIincKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKckLDKSEENA 575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   302 DALQLETLKQEAAKLAAHN--TQLQARIE--TLDCERSQQEAQLLAERG-------------------HFEEEKQQLASL 358
Cdd:pfam05483  576 RSIEYEVLKKEKQMKILENkcNNLKKQIEnkNKNIEELHQENKALKKKGsaenkqlnayeikvnklelELASAKQKFEEI 655

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   359 IADLQSSISNLSQAKEELeqASQAQGAQLTAQVASLTALNTTLQ-QQQDQELASLKEQAKKEQAQMVQSL---------- 427
Cdd:pfam05483  656 IDNYQKEIEDKKISEEKL--LEEVEKAKAIADEAVKLQKEIDKRcQHKIAEMVALMEKHKHQYDKIIEERdselglyknk 733

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 344240178   428 -QEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAR 480
Cdd:pfam05483  734 eQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKDKK 787
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 449-617 3.20e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 44.51  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   449 KLKEQQLEEAAKDQEAAR--QDHAQQLAIVAEAREASLRERDAARQQLETLEKEKaakleslqQQLEAANEARDSVQTSV 526
Cdd:pfam13851   30 SLKEEIAELKKKEERNEKlmSEIQQENKRLTEPLQKAQEEVEELRKQLENYEKDK--------QSLKNLKARLKVLEKEL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   527 TQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHV---TELEAQLKaeQQKVAEREKVMQEK-AQLQEQLLALE---ETL 599
Cdd:pfam13851  102 KDLKWEHEVLEQRFEKVERERDELYDKFEAAIQDVqqkTGLKNLLL--EKKLQALGETLEKKeAQLNEVLAAANldpDAL 179

                          170       180
                   ....*....|....*....|.
gi 344240178   600 QITKGSLEE---EKHRTADAL 617
Cdd:pfam13851  180 QAVTEKLEDvleSKNQLIKDL 200
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
523-647 3.56e-04

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 45.42  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  523 QTSVTQVQQEKAELSQKIEELHAcIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQIT 602
Cdd:COG1566    82 QAALAQAEAQLAAAEAQLARLEA-ELGAEAEIAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAA 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 344240178  603 KGSLE--EEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQ 647
Cdd:COG1566   161 QAQLEaaQAQLAQAQAGLREEEELAAAQAQVAQAEAALAQAELNLAR 207
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1037-1437 3.60e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.04  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1037 EGLTHSLESERASRAEQDKALETLQGQLEEKTQELghsQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERK 1116
Cdd:pfam07888   51 EAANRQREKEKERYKRDREQWERQRRELESRVAEL---KEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAH 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1117 SSLISSLEEEVSILNRQVLEKEGESKELKrlvvaeseksqkleerlrllqvetasssaRAAERSSALREEVQSLREEVEK 1196
Cdd:pfam07888  128 EARIRELEEDIKTLTQRVLERETELERMK-----------------------------ERAKKAGAQRKEEEAERKQLQA 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1197 QRVISENLRQELTSQAeraeelgQELKAWQEkffqkEQALSALQLEHTSTQalVSELLPAKHLCQQLQAEQAAAEKRHRE 1276
Cdd:pfam07888  179 KLQQTEEELRSLSKEF-------QELRNSLA-----QRDTQVLQLQDTITT--LTQKLTTAHRKEAENEALLEELRSLQE 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1277 EIEQSKQAAGGLRAEL--MRAQRELG--ELGPLRQKVAEQE----RAAQQLRAEKASYAEQLSMLKKAhgllAEENRGLG 1348
Cdd:pfam07888  245 RLNASERKVEGLGEELssMAAQRDRTqaELHQARLQAAQLTlqlaDASLALREGRARWAQERETLQQS----AEADKDRI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1349 ERANLGRQFLEVELDQAR---EKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTakyegakvkvlEERQRFQEERQK 1425
Cdd:pfam07888  321 EKLSAELQRLEERLQEERmerEKLEVELGREKDCNRVQLSESRRELQELKASLRVAQ-----------KEKEQLQAEKQE 389

                          410
                   ....*....|..
gi 344240178  1426 LTAQVEELSKKL 1437
Cdd:pfam07888  390 LLEYIRQLEQRL 401
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 350-526 3.72e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  350 EEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTL------QQQQDQELASLKEQAKKEQAQM 423
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELedlekeIKRLELEIEEVEARIKKYEEQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  424 VQSLQEQEQAAqgLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDhaqqlaiVAEAREaslrERDAARQQLETLEKEKAA 503
Cdd:COG1579    83 GNVRNNKEYEA--LQKEIESLKRRISDLEDEILELMERIEELEEE-------LAELEA----ELAELEAELEEKKAELDE 149

                         170       180
                  ....*....|....*....|...
gi 344240178  504 KLESLQQQLEAANEARDSVQTSV 526
Cdd:COG1579   150 ELAELEAELEELEAEREELAAKI 172
F-BAR_FCHO2 cd07673
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein; ...
 407-590 3.91e-04

The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein; F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. The specific function of FCH domain Only 2 (FCHO2) is still unknown. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCHO1 and endophilin interacting protein 1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.


Pssm-ID: 153357 [Multi-domain]  Cd Length: 269  Bit Score: 45.05  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  407 QELasLKEQAKKEQAQMVQSLQEQEQAAQGLR--QQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQlaivAEAREASL 484
Cdd:cd07673    91 QEL--IKEVQKYGEEQVKSHKKTKEEVAGTLEavQNIQSITQALQKSKENYNAKCLEQERLKKEGATQ----REIEKAAV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  485 RERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTel 564
Cdd:cd07673   165 KSKKATESYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIRIKEIIGSYSNSVKEIHIQIGQVHEEFINNMANTT-- 242

                         170       180
                  ....*....|....*....|....*.
gi 344240178  565 eaqLKAEQQKVAEREKVMQEKAQLQE 590
Cdd:cd07673   243 ---VESLIQKFAESKGTGKERPGPIE 265
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
335-571 3.92e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 45.84  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  335 SQQEAQLLaerghFEEEKQ--------QLASLIADLQSSISNLSQAKEELEQASQAQGAQ------LTAQVASLTALNtt 400
Cdd:COG0497   130 GQHEHQSL-----LDPDAQrelldafaGLEELLEEYREAYRAWRALKKELEELRADEAERareldlLRFQLEELEAAA-- 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  401 LQQQQDQELA----------SLKEQAkkeqAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAAR---Q 467
Cdd:COG0497   203 LQPGEEEELEeerrrlsnaeKLREAL----QEALEALSGGEGGALDLLGQALRALERLAEYDPSLAELAERLESALielE 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  468 DHAQQLAIVAEAREASLRERDAARQQLETLEKEK----------AAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELS 537
Cdd:COG0497   279 EAASELRRYLDSLEFDPERLEEVEERLALLRRLArkygvtveelLAYAEELRAELAELENSDERLEELEAELAEAEAELL 358

                         250       260       270
                  ....*....|....*....|....*....|....
gi 344240178  538 QKIEELHacieaahqEQRQAQAhvTELEAQLKAE 571
Cdd:COG0497   359 EAAEKLS--------AARKKAA--KKLEKAVTAE 382
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 1417-1516 3.94e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 46.10  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1417 QRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKE-QAAEHYKLQMEK 1495
Cdd:PRK11448  145 HALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSqERKQKRKEITDQ 224

                          90       100
                  ....*....|....*....|..
gi 344240178 1496 AKTHYDAKKQQNQELQD-QLRD 1516
Cdd:PRK11448  225 AAKRLELSEEETRILIDqQLRK 246
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 380-542 4.02e-04

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 45.49  E-value: 4.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   380 SQAQGAQLTAQVASLTALNTTLQQQQDQelaslKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQlssslklKEQQLEEAA 459
Cdd:pfam00529   56 YQAALDSAEAQLAKAQAQVARLQAELDR-----LQALESELAISRQDYDGATAQLRAAQAAVKA-------AQAQLAQAQ 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   460 KDQEAARQDHAQQLAIvaeaREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQK 539
Cdd:pfam00529  124 IDLARRRVLAPIGGIS----RESLVTAGALVAQAQANLLATVAQLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAE 199


                   ...
gi 344240178   540 IEE 542
Cdd:pfam00529  200 LKL 202
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 168-494 4.03e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 46.32  E-value: 4.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   168 ELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHnkASQEWA 247
Cdd:pfam01576  778 DLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDL--AASERA 855

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   248 EKQTHLEK-----ELSTALQDKKYLEEKNEILQGKLSQLEErasqqcespaqekgevlgdalQLETLKQEAAKLAAHNTQ 322
Cdd:pfam01576  856 RRQAQQERdeladEIASGASGKSALQDEKRRLEARIAQLEE---------------------ELEEEQSNTELLNDRLRK 914

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   323 LQARIETLDcersqqeAQLLAERGH---FEEEKQQLASLIADLQSSISnlsqakeELEQASQAQgaqLTAQVASLTALNT 399
Cdd:pfam01576  915 STLQVEQLT-------TELAAERSTsqkSESARQQLERQNKELKAKLQ-------EMEGTVKSK---FKSSIAALEAKIA 977

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   400 TLQQQQDQEL------ASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEA---AKDQEAARQDHA 470
Cdd:pfam01576  978 QLEEQLEQESrerqaaNKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAeeeASRANAARRKLQ 1057

                          330       340
                   ....*....|....*....|....
gi 344240178   471 QQLAIVAEAREASLRERDAARQQL 494
Cdd:pfam01576 1058 RELDDATESNESMNREVSTLKSKL 1081
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
191-425 4.42e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 4.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  191 QNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFN--DLTEEHNKASQEWAEkqthLEKELSTALQDKKYLE 268
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGlvDLSEEAKLLLQQLSE----LESQLAEARAELAEAE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  269 EKNEILQGKLSQLEERASQQCESPAqekgeVLGDALQLETLKQEAAKLAAHNT-------QLQARIETLDCERSQQEAQL 341
Cdd:COG3206   240 ARLAALRAQLGSGPDALPELLQSPV-----IQQLRAQLAELEAELAELSARYTpnhpdviALRAQIAALRAQLQQEAQRI 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  342 L----AERGHFEEEKQQLASLIADLQSSISNLSQAkeeleqasQAQGAQLTAQVASLTALNTTLQQQQDQelASLKEQAK 417
Cdd:COG3206   315 LasleAELEALQAREASLQAQLAQLEARLAELPEL--------EAELRRLEREVEVARELYESLLQRLEE--ARLAEALT 384


                  ....*...
gi 344240178  418 KEQAQMVQ 425
Cdd:COG3206   385 VGNVRVID 392
PRK12704 PRK12704
phosphodiesterase; Provisional
 452-631 4.68e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.54  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  452 EQQLEEAAKDQEAARQDhaqqlaIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQ 531
Cdd:PRK12704   41 KRILEEAKKEAEAIKKE------ALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKREEELEK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  532 EKAELSQK---IEELHACIEAAHQEQRQaqahvtELE--AQLKAEQQKvaerEKVMQEkaqlqeqllaLEETLQITKGSL 606
Cdd:PRK12704  115 KEKELEQKqqeLEKKEEELEELIEEQLQ------ELEriSGLTAEEAK----EILLEK----------VEEEARHEAAVL 174

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 344240178  607 ----EEEKHRTADALAEQ------QRCVTKMEAES 631
Cdd:PRK12704  175 ikeiEEEAKEEADKKAKEilaqaiQRCAADHVAET 209
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1275-1544 4.87e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 4.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1275 REEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRA--EKASYAEQL----SMLKKAHGLLAEENRGLG 1348
Cdd:COG5185   274 AESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAaeAEQELEESKreteTGIQNLTAEIEQGQESLT 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1349 ERANLGRQFLE-VELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1427
Cdd:COG5185   354 ENLEAIKEEIEnIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQAT 433

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1428 AQVEELSKKLTEY-DQASKVQQQKLKAFQAQGGESQQEV-QRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1505
Cdd:COG5185   434 SSNEEVSKLLNELiSELNKVMREADEESQSRLEEAYDEInRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLE 513

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 344240178 1506 QNQELQDQ----LRDLEQLQKENKELRAEAERLGRELQQAGLK 1544
Cdd:COG5185   514 GVRSKLDQvaesLKDFMRARGYAHILALENLIPASELIQASNA 556
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 459-739 5.05e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.71  E-value: 5.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   459 AKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSvtQVQQEKAELSQ 538
Cdd:pfam15709  275 VEDPWLSSKYDAEESQVSIDGRSSPTQTFVVTGNMESEEERSEEDPSKALLEKREQEKASRDRLRAE--RAEMRRLEVER 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   539 KIEElhacieaaHQEQRQaqahvteleaqlkaEQQKVAEREKVMQEKAQLQEQLLAleETLQITKGSLEEEKHRTADala 618
Cdd:pfam15709  353 KRRE--------QEEQRR--------------LQQEQLERAEKMREELELEQQRRF--EEIRLRKQRLEEERQRQEE--- 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   619 eqqrcvtkmEAESRSLMEQREQEQKALEQEKAGRKglearLQQLEEARQAEtealrrELAEATASQHRAESESEQLIREv 698
Cdd:pfam15709  406 ---------EERKQRLQLQAAQERARQQQEEFRRK-----LQELQRKKQQE------EAERAEAEKQRQKELEMQLAEE- 464

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 344240178   699 eswQKRFeARQQEEARYSAMIQEQLAAlkgdhEKAGQEAQE 739
Cdd:pfam15709  465 ---QKRL-MEMAEEERLEYQRQKQEAE-----EKARLEAEE 496
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 225-593 5.12e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 45.60  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  225 LQQLQGAFNDLT---EEHNKASQEWAEKQTHLEKELST-------ALqdkKYLEEKNEILQGKLSQLEERAsqqcespaq 294
Cdd:PRK04778  121 IEQILEELQELLeseEKNREEVEQLKDLYRELRKSLLAnrfsfgpAL---DELEKQLENLEEEFSQFVELT--------- 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  295 EKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLA------ERG-HFEEekQQLASLIADLQSSIS 367
Cdd:PRK04778  189 ESGDYVEAREILDQLEEELAALEQIMEEIPELLKELQTELPDQLQELKAgyrelvEEGyHLDH--LDIEKEIQDLKEQID 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  368 NLSQAKEELEqasqaqgaqltaqVASLTALNTTLQQQQDQELASL------KEQAKKEQAQMVQSLQEQEQAAQGLRQQV 441
Cdd:PRK04778  267 ENLALLEELD-------------LDEAEEKNEEIQERIDQLYDILerevkaRKYVEKNSDTLPDFLEHAKEQNKELKEEI 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  442 EQLSSSLKLKE------QQLEEAAKDQEAARQDHAQQLAiVAEAREASLRER-DAARQQLETLEKEKAAKLESLQQQLEA 514
Cdd:PRK04778  334 DRVKQSYTLNEselesvRQLEKQLESLEKQYDEITERIA-EQEIAYSELQEElEEILKQLEEIEKEQEKLSEMLQGLRKD 412

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  515 ANEARDSVQtsvtQVQQEKAELSQKIEELH----------------ACIEAAHQEQRQAQAHVTELEAQL-KAEQQ--KV 575
Cdd:PRK04778  413 ELEAREKLE----RYRNKLHEIKRYLEKSNlpglpedylemffevsDEIEALAEELEEKPINMEAVNRLLeEATEDveTL 488

                         410
                  ....*....|....*...
gi 344240178  576 AEREKVMQEKAQLQEQLL 593
Cdd:PRK04778  489 EEETEELVENATLTEQLI 506
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 428-688 5.13e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 45.71  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  428 QEQEQAAQGlRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLaiVAEAreaslRERDAARQQLETLEKEKAAKLES 507
Cdd:PRK05035  443 QEKKKAEEA-KARFEARQARLEREKAAREARHKKAAEARAAKDKDA--VAAA-----LARVKAKKAAATQPIVIKAGARP 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  508 LQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAhQEQRQAQAHVTElEAQLKAEQQKVAEREKVMQEKAQ 587
Cdd:PRK05035  515 DNSAVIAAREARKAQARARQAEKQAAAAADPKKAAVAAAIARA-KAKKAAQQAANA-EAEEEVDPKKAAVAAAIARAKAK 592

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  588 LQEQLLALEETlqiTKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKAleQEKAGRKGLEARLQQLEEARQ 667
Cdd:PRK05035  593 KAAQQAASAEP---EEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKA--AVAAAIARAKARKAAQQQANA 667

                         250       260
                  ....*....|....*....|.
gi 344240178  668 AETEALRRELAEATASQHRAE 688
Cdd:PRK05035  668 EPEEAEDPKKAAVAAAIARAK 688
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 995-1238 5.64e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 5.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  995 ASAPEAQLETVRKTEApdpEVEALRAEVSKLEQQcqqqkqqveglthsLESERASRAEQDKALETLQGQLEEKTQELGHS 1074
Cdd:COG4942    12 ALAAAAQADAAAEAEA---ELEQLQQEIAELEKE--------------LAALKKEEKALLKQLAALERRIAALARRIRAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1075 QAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSS-----LISSLEEEVSILNRQVLEKEgESKELKRLVV 1149
Cdd:COG4942    75 EQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRqpplaLLLSPEDFLDAVRRLQYLKY-LAPARREQAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1150 AESEKSQKLEERLRLLQVETASSSARAAErssaLREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKF 1229
Cdd:COG4942   154 ELRADLAELAALRAELEAERAELEALLAE----LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229


                  ....*....
gi 344240178 1230 FQKEQALSA 1238
Cdd:COG4942   230 ARLEAEAAA 238
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 626-752 5.80e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.59  E-value: 5.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  626 KMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASqhrAESESEQLIREVESWQKRF 705
Cdd:PRK00409  524 SLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKE---AKKEADEIIKELRQLQKGG 600

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 344240178  706 EARQQEEArysamIQEQLAALKGDHEKAgQEAQEEAVEVHGEGQIGE 752
Cdd:PRK00409  601 YASVKAHE-----LIEARKRLNKANEKK-EKKKKKQKEKQEELKVGD 641
DUF4200 pfam13863
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ...
 1384-1490 5.84e-04

Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.


Pssm-ID: 464003 [Multi-domain]  Cd Length: 119  Bit Score: 42.17  E-value: 5.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1384 LAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQ 1463
Cdd:pfam13863    1 LLEKKREMFLVQLALDAKREEIERLEELLKQREEELEKKEQELKEDLIKFDKFLKENDAKRRRALKKAEEETKLKKEKEK 80

                           90       100
                   ....*....|....*....|....*..
gi 344240178  1464 EVQRLQAQLNELQTQLSQKEQAAEHYK 1490
Cdd:pfam13863   81 EIKKLTAQIEELKSEISKLEEKLEEYK 107
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 162-336 5.86e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 5.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   162 SSQESReLEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNK 241
Cdd:TIGR02169  808 SRIEAR-LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD 886

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   242 ASQEWAEKQTHLEK------ELSTALQDKKY----LEEKNEILQGKLSQLEERASQQCESPA---------------QEK 296
Cdd:TIGR02169  887 LKKERDELEAQLRElerkieELEAQIEKKRKrlseLKAKLEALEEELSEIEDPKGEDEEIPEeelsledvqaelqrvEEE 966

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 344240178   297 GEVLGD------------ALQLETLKQEAAKLAAHNTQLQARIETLDCERSQ 336
Cdd:TIGR02169  967 IRALEPvnmlaiqeyeevLKRLDELKEKRAKLEEERKAILERIEEYEKKKRE 1018
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
566-750 6.03e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 45.25  E-value: 6.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  566 AQLKAEQQK-VAEREKVMQEKAQLQEQLLALEETLQITkgslEEEKHRTADALAEQQrcvtKMEAEsrslmEQREQEQKA 644
Cdd:COG2268   195 AEIIRDARIaEAEAERETEIAIAQANREAEEAELEQER----EIETARIAEAEAELA----KKKAE-----ERREAETAR 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  645 LEQEKAGRkgLEARLQQLEEARQAETEALRRELAEATASQHRAEsesEQLIREVeswqkrfeaRQQEEARYSAMIQEQLA 724
Cdd:COG2268   262 AEAEAAYE--IAEANAEREVQRQLEIAEREREIELQEKEAEREE---AELEADV---------RKPAEAEKQAAEAEAEA 327

                         170       180       190
                  ....*....|....*....|....*....|.
gi 344240178  725 -----ALKGDHEKAGQEAQEEAVEVHGEGQI 750
Cdd:COG2268   328 eaeaiRAKGLAEAEGKRALAEAWNKLGDAAI 358
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1116-1578 6.57e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.60  E-value: 6.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1116 KSSLISSLEE-----EVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLR-----LLQVETASSSARAAERSSALRE 1185
Cdd:pfam12128  199 KSMIVAILEDdgvvpPKSRLNRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNtlesaELRLSHLHFGYKSDETLIASRQ 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1186 EVQSLREEVEKQRVISenLRQELtsqAERAEELGQELKAWQEKFFQKEQALSALQLEHtstQALVSELLPAKHLCQQLQA 1265
Cdd:pfam12128  279 EERQETSAELNQLLRT--LDDQW---KEKRDELNGELSAADAAVAKDRSELEALEDQH---GAFLDADIETAAADQEQLP 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1266 EQAAAEKRHREEIEQSKQAAGGL-----RAELMRAQRELGELGPLRQKVAEQ-ERAAQQLRAEKASYAEQLSMLKKAH-G 1338
Cdd:pfam12128  351 SWQSELENLEERLKALTGKHQDVtakynRRRSKIKEQNNRDIAGIKDKLAKIrEARDRQLAVAEDDLQALESELREQLeA 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1339 LLAEENRG-LGERANLGRQFLEVELDQAREKYVQELAAvrTDAETHLAEMRQEA-----QSTTRELEVMTAKYEGAKVKV 1412
Cdd:pfam12128  431 GKLEFNEEeYRLKSRLGELKLRLNQATATPELLLQLEN--FDERIERAREEQEAanaevERLQSELRQARKRRDQASEAL 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1413 LEERQRFQEERQKLTAQVEELSKK---LTEY--DQASKVQQQKLKAFQAQ------------GGESQQEVQRLQAQLNEL 1475
Cdd:pfam12128  509 RQASRRLEERQSALDELELQLFPQagtLLHFlrKEAPDWEQSIGKVISPEllhrtdldpevwDGSVGGELNLYGVKLDLK 588

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1476 QTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQlrdLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHL 1555
Cdd:pfam12128  589 RIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQ---LVQANGELEKASREETFARTALKNARLDLRRLFDEKQSE 665

                          490       500
                   ....*....|....*....|....
gi 344240178  1556 SAQV-RSLEAQVAHADQQLRDLGK 1578
Cdd:pfam12128  666 KDKKnKALAERKDSANERLNSLEA 689
TorS_sensor_domain cd16172
sensor domain of the sensor histidine kinase TorS; TorS is part of the trimethylamine-N-oxide ...
 353-600 7.01e-04

sensor domain of the sensor histidine kinase TorS; TorS is part of the trimethylamine-N-oxide (TMAO) reductase (Tor) pathway, which consists TorT, a periplasmic binding protein that binds TMAO; TorS, a sensor histidine kinase that forms a complex with TorT, and TorR, the response regulator. The Tor pathway is involved in regulating a cellular response to trimethylamine-N-oxide (TMAO), a terminal electron receptor in anaerobic respiration. TorS consists of a periplasmic sensor domain, as well as a HAMP domain, a histidine kinase domain, and a receiver domain.


Pssm-ID: 293930 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 7.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  353 QQLASLIADLQSSISNLSQAKEELEQasQAQGAQLTAQVASLTALNTTLQQQ--QDQELASLKEQAKkeqaQMVQSLQEQ 430
Cdd:cd16172     2 RQLSELSSRIIASAQLLANADSEAER--QQQGRQLTAQLEALLRLLKALGQDsfDSFLLSRLEQTVQ----EIIDNLAQL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  431 EQAAQ---GLRQQVEQLSSSLKLKEQQLEEAAKDQeaarqdhAQQLAIVAEAREASL------RERDAARQQLETL---- 497
Cdd:cd16172    76 GELVGqrlQLRQQFQQLFERLRAAAGELAQLARTQ-------VANASTIAVANVSGLydlieqNDKEAAYQALDRLievd 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  498 ----EKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHqeqRQAQAHvtELEAQLKAEQQ 573
Cdd:cd16172   149 ldllERMHELRLLALQLGNLINELRTASDIARLAELRQQFNANLAILQRRVQAVEDPG---RRAQMA--QLLSDLEQGQG 223

                         250       260
                  ....*....|....*....|....*..
gi 344240178  574 KVAEREKVMQEKAQLQEQLLALEETLQ 600
Cdd:cd16172   224 LFALRRQLLALEQRLQALMQNNLVLFT 250
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
336-699 7.02e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.89  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  336 QQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQdQELASLKEQ 415
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQAR-SELEQLEEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  416 AKKEQAQMVQSLQEQEQAAQGLrQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLE 495
Cdd:COG4372    82 LEELNEQLQAAQAELAQAQEEL-ESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  496 TLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKV 575
Cdd:COG4372   161 SLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  576 AEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGL 655
Cdd:COG4372   241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAA 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 344240178  656 EARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVE 699
Cdd:COG4372   321 LLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAE 364
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 321-469 7.79e-04

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 43.83  E-value: 7.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   321 TQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNtt 400
Cdd:pfam12795   88 LQTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQRLQQIRNRLNGPAPPGEPLSEAQRWALQAELAALKAQI-- 165

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178   401 lqQQQDQELAS---LKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLssSLKLKEQQLEEAAKDQEAARQDH 469
Cdd:pfam12795  166 --DMLEQELLSnnnRQDLLKARRDLLTLRIQRLEQQLQALQELLNEK--RLQEAEQAVAQTEQLAEEAAGDH 233
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 910-1563 7.89e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 7.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   910 KAELEVRLQNtLNEQRVEFAALQEALDHA-------LTEKEGKDQELAKLRGQEAAQRTELKELQQTLEHLKTQLVKKEK 982
Cdd:TIGR04523  109 NSEIKNDKEQ-KNKLEVELNKLEKQKKENkknidkfLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQK 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   983 EQHPAGStggeEASAPEAQLETVRKTEAPDPEveaLRAEVSKLEQQCQQqkqqvegLTHSLESERASRAEQDKALETLQG 1062
Cdd:TIGR04523  188 NIDKIKN----KLLKLELLLSNLKKKIQKNKS---LESQISELKKQNNQ-------LKDNIEKKQQEINEKTTEISNTQT 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1063 QLEEKTQELghsqaasasaqreltalhakaqdhskaeEEWKAQVARGQQEAERKSSLISSLEE-------EVSILNRQvl 1135
Cdd:TIGR04523  254 QLNQLKDEQ----------------------------NKIKKQLSEKQKELEQNNKKIKELEKqlnqlksEISDLNNQ-- 303

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1136 EKEGESKELKrlvvaesEKSQKLEERLRLLQVETASSSaraaERSSALREEVQSLREEVEKqrviSENLRQELTSQAERA 1215
Cdd:TIGR04523  304 KEQDWNKELK-------SELKNQEKKLEEIQNQISQNN----KIISQLNEQISQLKKELTN----SESENSEKQRELEEK 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1216 EELGQELKAWQEKFFQKEQALSalqlehTSTQALVSELlpakhlcqqlqaeqaaaekRHREEIEQSKQaagglraelmra 1295
Cdd:TIGR04523  369 QNEIEKLKKENQSYKQEIKNLE------SQINDLESKI-------------------QNQEKLNQQKD------------ 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1296 qrelGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAhgllaeenrglgeranlgrqflevelDQAREKYVQELAA 1375
Cdd:TIGR04523  412 ----EQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQ--------------------------DSVKELIIKNLDN 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1376 VRTDAETHLAEMRQEAQSTTRELEvmtakyegAKVKVLEERqrfQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQ 1455
Cdd:TIGR04523  462 TRESLETQLKVLSRSINKIKQNLE--------QKQKELKSK---EKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLE 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1456 AQGGESQQEVQRLQAQLNELQTQL--SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDqlrDLEQLQKENKELRAEAER 1533
Cdd:TIGR04523  531 SEKKEKESKISDLEDELNKDDFELkkENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQE---LIDQKEKEKKDLIKEIEE 607

                          650       660       670
                   ....*....|....*....|....*....|
gi 344240178  1534 LGRELQQAGLKTKEAEQACRHLSAQVRSLE 1563
Cdd:TIGR04523  608 KEKKISSLEKELEKAKKENEKLSSIIKNIK 637
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 322-794 8.10e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 8.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   322 QLQARIETLDCERSQQEAQLLAERGHF---EEEKQQLASLIADLQSSISNLsqaKEELEQASQaqgaQLTAQVASLTALN 398
Cdd:TIGR04523   37 QLEKKLKTIKNELKNKEKELKNLDKNLnkdEEKINNSNNKIKILEQQIKDL---NDKLKKNKD----KINKLNSDLSKIN 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   399 TTLQQQQDQ------ELASLKEQAKKEQAQMVQSLQEQEQaaqgLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQ 472
Cdd:TIGR04523  110 SEIKNDKEQknklevELNKLEKQKKENKKNIDKFLTEIKK----KEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNI 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   473 LAIVAEAReaslRERDAARQQLETLEKeKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQ 552
Cdd:TIGR04523  186 QKNIDKIK----NKLLKLELLLSNLKK-KIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKD 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   553 EQ--------------RQAQAHVTELEAQLkaeQQKVAEREKVMQEKAQ-----LQEQLLALEETLQITKGSLEEEKHRT 613
Cdd:TIGR04523  261 EQnkikkqlsekqkelEQNNKKIKELEKQL---NQLKSEISDLNNQKEQdwnkeLKSELKNQEKKLEEIQNQISQNNKII 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   614 A---DALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEearqAETEALRRELAEATASQHRAESE 690
Cdd:TIGR04523  338 SqlnEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLE----SQINDLESKIQNQEKLNQQKDEQ 413

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   691 SEQLIREVESWQKRFEARQQEEARYSAMIQ---EQLAALKGDHEKAGQ--EAQEEAVEVHgEGQIGEQQSPLAQLHTTLA 765
Cdd:TIGR04523  414 IKKLQQEKELLEKEIERLKETIIKNNSEIKdltNQDSVKELIIKNLDNtrESLETQLKVL-SRSINKIKQNLEQKQKELK 492

                          490       500
                   ....*....|....*....|....*....
gi 344240178   766 RALQQVKEKEVRAQKLADDLTTLQEKMAS 794
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEKVKDLTKKISS 521
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 2649-2810 8.26e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 45.13  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2649 VLFAVTSM-LSFTRLAYILPAHESLGTLQISIGRMI-DDMIRFMFILMIILTAF---LCGLNNIYVPYQETEKLGNFNET 2723
Cdd:cd22194   474 LACLVLAMaLGWANMLYYTRGFQSLGIYSVMIQKVIlNDVLKFLLVYILFLLGFgvaLASLIEDCPDDSECSSYGSFSDA 553

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 2724 FQFLFWTMFGMEEHTVVDMPQFlvPEfVGRALYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFR 2803
Cdd:cd22194   554 VLELFKLTIGLGDLEIQQNSKY--PI-LFLLLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEK 630


                  ....*..
gi 344240178 2804 eglTLPV 2810
Cdd:cd22194   631 ---SLPE 634
PRK11281 PRK11281
mechanosensitive channel MscK;
928-1240 8.34e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 45.29  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  928 FAALQEALDHALTEKEGKDQ--ELAKLRGQEAAQRTELKELQQTLEHLktqlvkkekeqhpagstggeeasapeAQLETV 1005
Cdd:PRK11281   25 AFARAASNGDLPTEADVQAQldALNKQKLLEAEDKLVQQDLEQTLALL--------------------------DKIDRQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1006 RKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEqDKALETLQGQLEEKTQELGHSQAASASAQREL 1085
Cdd:PRK11281   79 KE------ETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLS-TLSLRQLESRLAQTLDQLQNAQNDLAEYNSQL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1086 TALHAKAQdhsKAEEEWKAQVARGQQ-----------EAERKSSLISSLEEEVSILN------RQVLEKEGESKELKRLV 1148
Cdd:PRK11281  152 VSLQTQPE---RAQAALYANSQRLQQirnllkggkvgGKALRPSQRVLLQAEQALLNaqndlqRKSLEGNTQLQDLLQKQ 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1149 VAE-SEKSQKLEERLRLLQveTASSSARAAErSSALREEVQSLREEVEKQ------RVISENLR--QELTSQAERAEELG 1219
Cdd:PRK11281  229 RDYlTARIQRLEHQLQLLQ--EAINSKRLTL-SEKTVQEAQSQDEAARIQanplvaQELEINLQlsQRLLKATEKLNTLT 305

                         330       340
                  ....*....|....*....|....*...
gi 344240178 1220 QE---LKAWQEKFFQKEQAL----SALQ 1240
Cdd:PRK11281  306 QQnlrVKNWLDRLTQSERNIkeqiSVLK 333
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 223-377 8.57e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.76  E-value: 8.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  223 SHLQQLQGAFNDLTEEHNKASQEWAEkqthLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQqcespAQEK-GEVLG 301
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAA----LEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK-----YEEQlGNVRN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  302 ----DALQ--LETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEE 375
Cdd:COG1579    88 nkeyEALQkeIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREE 167


                  ..
gi 344240178  376 LE 377
Cdd:COG1579   168 LA 169
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1047-1198 8.96e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.76  E-value: 8.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1047 RASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQV--ARGQQEAERKSSLISSLE 1124
Cdd:COG1579    23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnVRNNKEYEALQKEIESLK 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178 1125 EEVSILNRQVLEKEGESKELKRLVvaeseksQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQR 1198
Cdd:COG1579   103 RRISDLEDEILELMERIEELEEEL-------AELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELA 169
PRK11281 PRK11281
mechanosensitive channel MscK;
1272-1562 9.15e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.90  E-value: 9.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1272 KRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLgerA 1351
Cdd:PRK11281   76 DRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQL---V 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1352 NLgrqfleveldQAREKYVQelaAVRTDAETHLAEMRQEAQSTTrelevmtakyEGAKVKVLEERQRFQEERQKLTAQVE 1431
Cdd:PRK11281  153 SL----------QTQPERAQ---AALYANSQRLQQIRNLLKGGK----------VGGKALRPSQRVLLQAEQALLNAQND 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1432 ELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNelQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1511
Cdd:PRK11281  210 LQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQEAIN--SKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEIN 287

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178 1512 DQLRD--LEQLQKENkelraeaerlgrELQQAGLKTKE----AEQACRHLSAQVRSL 1562
Cdd:PRK11281  288 LQLSQrlLKATEKLN------------TLTQQNLRVKNwldrLTQSERNIKEQISVL 332
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1053-1301 9.40e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 9.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1053 QDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNR 1132
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1133 QVLEKEgesKELKRLVVAesekSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEkqrvisenlrqELTSQA 1212
Cdd:COG4942    98 ELEAQK---EELAELLRA----LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAE-----------ELRADL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1213 ERAEELGQELKawqekffQKEQALSALQLEHTSTQALVSELLPAKhlcQQLQAEQAAAEKRHREEIEQSKQAAGGLRAEL 1292
Cdd:COG4942   160 AELAALRAELE-------AERAELEALLAELEEERAALEALKAER---QKLLARLEKELAELAAELAELQQEAEELEALI 229


                  ....*....
gi 344240178 1293 MRAQRELGE 1301
Cdd:COG4942   230 ARLEAEAAA 238
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
362-599 9.45e-04

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 44.68  E-value: 9.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  362 LQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQD--QELASLKEQ----AKK---EQAQMVQSLQEQEQ 432
Cdd:PRK09793  273 MHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQNADnaRQASELAKNaattAQAggvQVSTMTHTMQEIAT 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  433 AAQGLRQQVEQLsSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVA-EAREASLRERDAARqQLETLEKEKAAKLESLQQQ 511
Cdd:PRK09793  353 SSQKIGDIISVI-DGIAFQTNILALNAAVEAARAGEQGRGFAVVAgEVRNLASRSAQAAK-EIKGLIEESVNRVQQGSKL 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  512 LEAANEARDSVQTSVTQVQQEKAElsqkieelhacIEAAHQEQRQAQAHVTeleaqlkaeqQKVAEREKVMQEKAQLQEQ 591
Cdd:PRK09793  431 VNNAAATMTDIVSSVTRVNDIMGE-----------IASASEEQRRGIEQVA----------QAVSQMDQVTQQNASLVEE 489


                  ....*...
gi 344240178  592 LLALEETL 599
Cdd:PRK09793  490 AAVATEQL 497
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 1396-1578 9.81e-04

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 43.13  E-value: 9.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1396 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKlteydqaskVQQQKLKAFQAQGGESQQEVQRLQAQLNEL 1475
Cdd:pfam04012   32 RDMQSELVKARQALAQTIARQKQLERRLEQQTEQAKKLEEK---------AQAALTKGNEELAREALAEKKSLEKQAEAL 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1476 QTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQlrdlEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHL 1555
Cdd:pfam04012  103 ETQLAQQRSAVEQLRKQLAALETKIQQLKAKKNLLKAR----LKAAKAQEAVQTSLGSLSTSSATDSFERIEEKIEEREA 178

                          170       180
                   ....*....|....*....|...
gi 344240178  1556 SAQVRSLEAQVAHADQQLRDLGK 1578
Cdd:pfam04012  179 RADAAAELASAVDLDAKLEQAGI 201
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
305-600 1.06e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 43.75  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  305 QLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASqaqg 384
Cdd:COG1340    16 KIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELR---- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  385 aqltaqvasltalnttlqqqqdQELASLKEQAKKEQaQMVQSLQEQEQAAQGL--RQQVEQLSSS----LKLKEQQLEEA 458
Cdd:COG1340    92 ----------------------EELDELRKELAELN-KAGGSIDKLRKEIERLewRQQTEVLSPEeekeLVEKIKELEKE 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  459 AKDQEAARQDHAQQLAIVAEAREASlRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDsvqtsvtqvqqEKAELSQ 538
Cdd:COG1340   149 LEKAKKALEKNEKLKELRAELKELR-KEAEEIHKKIKELAEEAQELHEEMIELYKEADELRK-----------EADELHK 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  539 KIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVmQEKAQLQEQLLALEETLQ 600
Cdd:COG1340   217 EIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKRE-KEKEELEEKAEEIFEKLK 277
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
660-1222 1.12e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.91  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  660 QQLEEARQaETEALR--RELAEATASQHRAESESEQLIREVESW--QKRFEARQQEEARysamIQEQLAALKGDHEKAGQ 735
Cdd:COG4913   242 EALEDARE-QIELLEpiRELAERYAAARERLAELEYLRAALRLWfaQRRLELLEAELEE----LRAELARLEAELERLEA 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  736 ---EAQEEAVEVHGE-GQIGEQQspLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVaacLKTLVLKAGE 811
Cdd:COG4913   317 rldALREELDELEAQiRGNGGDR--LEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEE---FAALRAEAAA 391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  812 QQEmtslellkeppgAGNKESNWLEEQRggpfSSPQAALKAMEQEAEQMGSELerlrvalmksqgqqqeergqqerevAR 891
Cdd:COG4913   392 LLE------------ALEEELEALEEAL----AEAEAALRDLRRELRELEAEI-------------------------AS 430

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  892 LTRERSQAQADLAQekaAKAELEVRLQntLNEQRVEFAAlqEALDhaLTEKEGKDQ---ELAkLRGqeaaQRTEL----K 964
Cdd:COG4913   431 LERRKSNIPARLLA---LRDALAEALG--LDEAELPFVG--ELIE--VRPEEERWRgaiERV-LGG----FALTLlvppE 496

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  965 ELQQTLE-----HLKTQLV--KKEKEQHPAGSTGGEEASAPEaQLETvrkteAPDPEVEALRAEVSKL----------EQ 1027
Cdd:COG4913   497 HYAAALRwvnrlHLRGRLVyeRVRTGLPDPERPRLDPDSLAG-KLDF-----KPHPFRAWLEAELGRRfdyvcvdspeEL 570

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1028 QCQQQKQQVEGLTHSLES------ERASRAEQ------DKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDH 1095
Cdd:COG4913   571 RRHPRAITRAGQVKGNGTrhekddRRRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREAL 650

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1096 SKAEEEWKAQ--VARGQQEAERKSSLISSLEE---EVSILNRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETA 1170
Cdd:COG4913   651 QRLAEYSWDEidVASAEREIAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD 730

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178 1171 SSSARAAERSSALREEVQSLREEV-------EKQRVISENLRQELTSQAERAEELGQEL 1222
Cdd:COG4913   731 ELQDRLEAAEDLARLELRALLEERfaaalgdAVERELRENLEERIDALRARLNRAEEEL 789
PLN03188 PLN03188
kinesin-12 family protein; Provisional
 495-706 1.13e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 44.93  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  495 ETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSqkieelhacieaahQEQRQAQahvtELEaqlKAEQQK 574
Cdd:PLN03188 1047 KKLEQERLRWTEAESKWISLAEELRTELDASRALAEKQKHELD--------------TEKRCAE----ELK---EAMQMA 1105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  575 VAEREKVMQEKAQLQE---QLLALEETLQITKGSLEEEKHRTADALAEqQRCVTKMEAESRSLMEQREQEQKALEQEKag 651
Cdd:PLN03188 1106 MEGHARMLEQYADLEEkhiQLLARHRRIQEGIDDVKKAAARAGVRGAE-SKFINALAAEISALKVEREKERRYLRDEN-- 1182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  652 rKGLEARLQQLEEARQAETEALRReLAEA----TASQHR---AESESEQLIREVESWQKRFE 706
Cdd:PLN03188 1183 -KSLQAQLRDTAEAVQAAGELLVR-LKEAeealTVAQKRamdAEQEAAEAYKQIDKLKRKHE 1242
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
 488-596 1.16e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 43.95  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   488 DAARQQLETLEkekaAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHAcieaahQEQRQAQAHVTELEAQ 567
Cdd:TIGR04320  257 AALQAKLATAQ----ADLAAAQTALNTAQAALTSAQTAYAAAQAALATAQKELANAQA------QALQTAQNNLATAQAA 326

                           90       100       110
                   ....*....|....*....|....*....|
gi 344240178   568 LK-AEQQKVAEREKVMQEKAQLQEQLLALE 596
Cdd:TIGR04320  327 LAnAEARLAKAKEALANLNADLAKKQAALD 356
PRK11281 PRK11281
mechanosensitive channel MscK;
336-593 1.21e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  336 QQEAQLLAERGHFEEEKqqlASLIADLQSSISNLSQA---KEELEQASQ--AQGAQLTAQV-ASLTALNTTLQQQQDQEL 409
Cdd:PRK11281   42 QAQLDALNKQKLLEAED---KLVQQDLEQTLALLDKIdrqKEETEQLKQqlAQAPAKLRQAqAELEALKDDNDEETRETL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  410 ASLkeqakkEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKdQEAARQDHAQQL-AIVAEAREASLRERD 488
Cdd:PRK11281  119 STL------SLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQA-ALYANSQRLQQIrNLLKGGKVGGKALRP 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  489 AARQQLETlekEKAAkLE---SLQQQLEAANeardSVQTSVTQVQQ-EKAELSQKIEELHACIEAAHQEQRQAQAHVTEL 564
Cdd:PRK11281  192 SQRVLLQA---EQAL-LNaqnDLQRKSLEGN----TQLQDLLQKQRdYLTARIQRLEHQLQLLQEAINSKRLTLSEKTVQ 263

                         250       260       270
                  ....*....|....*....|....*....|..
gi 344240178  565 EAQLKAEQQKVAEREKVMQEKA---QLQEQLL 593
Cdd:PRK11281  264 EAQSQDEAARIQANPLVAQELEinlQLSQRLL 295
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 608-757 1.24e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 44.17  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   608 EEKHRTADALAEQQRCVTKMEAES--RSLMEQREQEQKALEQEKAGRKGLEA-----------RLQQLEEARQAETEALR 674
Cdd:pfam15709  329 EQEKASRDRLRAERAEMRRLEVERkrREQEEQRRLQQEQLERAEKMREELELeqqrrfeeirlRKQRLEEERQRQEEEER 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   675 RELAEATASQHRAESESEQLIREVESWQKRfeaRQQEEARYSAM-------IQEQLAAlkgDHEKAGQEAQEEAVEVHGE 747
Cdd:pfam15709  409 KQRLQLQAAQERARQQQEEFRRKLQELQRK---KQQEEAERAEAekqrqkeLEMQLAE---EQKRLMEMAEEERLEYQRQ 482

                          170
                   ....*....|
gi 344240178   748 GQIGEQQSPL 757
Cdd:pfam15709  483 KQEAEEKARL 492
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
295-463 1.32e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 43.88  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  295 EKGEVLgdaLQLETLKQEAAKlaahnTQLQARIETLDCERSQQEAQLLAErghfeeekQQLASLIADLQSSISNLSQAKE 374
Cdd:COG1566    68 KKGQVL---ARLDPTDLQAAL-----AQAEAQLAAAEAQLARLEAELGAE--------AEIAAAEAQLAAAQAQLDLAQR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  375 ELEQASQAQGAQLTAQvasltalnttlqqqqdQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQ--QVEQLSSSLKLKE 452
Cdd:COG1566   132 ELERYQALYKKGAVSQ----------------QELDEARAALDAAQAQLEAAQAQLAQAQAGLREeeELAAAQAQVAQAE 195

                         170
                  ....*....|.
gi 344240178  453 QQLEEAAKDQE 463
Cdd:COG1566   196 AALAQAELNLA 206
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1358-1551 1.45e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.74  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1358 LEVELDQAREKyVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKvkvlEERQRFQEERQKLTAQVEELSKKL 1437
Cdd:COG4372    50 LREELEQAREE-LEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ----EELESLQEEAEELQEELEELQKER 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1438 TEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHyDAKKQQNQELQDQLRDL 1517
Cdd:COG4372   125 QDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD-ELLKEANRNAEKEEELA 203

                         170       180       190
                  ....*....|....*....|....*....|....
gi 344240178 1518 EQLQKENKELRAEAERLGRELQQAGLKTKEAEQA 1551
Cdd:COG4372   204 EAEKLIESLPRELAEELLEAKDSLEAKLGLALSA 237
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 1319-1439 1.50e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 41.09  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1319 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANlgrqfleveldQAREKYVQELAAVRTDAEThLAEMRQEAQSTTREL 1398
Cdd:pfam07926    6 LQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAR-----------EAQQNYERELVLHAEDIKA-LQALREELNELKAEI 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 344240178  1399 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTE 1439
Cdd:pfam07926   74 AELKAEAESAKAELEESEESWEEQKKELEKELSELEKRIED 114
PRK09039 PRK09039
peptidoglycan -binding protein;
274-445 1.51e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.80  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  274 LQGKLSQLEERASQQCEspaqekgevLGDALQLETLkqeaaklaaHNTQLQARIETLDCERSQQEAqllaERGHFEEEKQ 353
Cdd:PRK09039   48 ISGKDSALDRLNSQIAE---------LADLLSLERQ---------GNQDLQDSVANLRASLSAAEA----ERSRLQALLA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  354 QLASLIADLQSSISNLSQAKEELEQASQAQGAQ---LTAQVASLTAlnttlQQQQDQELASLKEQAKKEQAQMVQSLQEQ 430
Cdd:PRK09039  106 ELAGAGAAAEGRAGELAQELDSEKQVSARALAQvelLNQQIAALRR-----QLAALEAALDASEKRDRESQAKIADLGRR 180

                         170
                  ....*....|....*
gi 344240178  431 EQAAqgLRQQVEQLS 445
Cdd:PRK09039  181 LNVA--LAQRVQELN 193
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1272-1551 1.54e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 43.36  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1272 KRHREEIEQSKQAAGGLRAEL--MRAQRELgelgpLRQKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE 1349
Cdd:COG1340    18 EELREEIEELKEKRDELNEELkeLAEKRDE-----LNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELRE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1350 ranlgrqflevELDQAREKYvQELAAVRTDaethLAEMRQEAQSTTRELE--VMTAKYEG---AKVKVLEERQRFQEERQ 1424
Cdd:COG1340    93 -----------ELDELRKEL-AELNKAGGS----IDKLRKEIERLEWRQQteVLSPEEEKelvEKIKELEKELEKAKKAL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1425 KLTAQVEELSKKLTE-YDQASKVQQQKlkafqaqgGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAK 1503
Cdd:COG1340   157 EKNEKLKELRAELKElRKEAEEIHKKI--------KELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADEL 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 344240178 1504 KQQNQELQDQLRDleqLQKENKELRAEAERLGRELQQAGLKtKEAEQA 1551
Cdd:COG1340   229 HEEIIELQKELRE---LRKELKKLRKKQRALKREKEKEELE-EKAEEI 272
PRK01156 PRK01156
chromosome segregation protein; Provisional
 349-700 1.62e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.12  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  349 EEEKQQLASLIADLQSSISNLSQAKEELeQASQAQGAQLTAQVASLTALNTTLQ----------QQQDQELASLKEQAKK 418
Cdd:PRK01156  165 ERNYDKLKDVIDMLRAEISNIDYLEEKL-KSSNLELENIKKQIADDEKSHSITLkeierlsieyNNAMDDYNNLKSALNE 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  419 EQAQ--MVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQ----------LAIVAEAREASLRE 486
Cdd:PRK01156  244 LSSLedMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDyfkykndienKKQILSNIDAEINK 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  487 RDAARQQLETLEK------EKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKaelsQKIEElhaciEAAHQEQRQAQAH 560
Cdd:PRK01156  324 YHAIIKKLSVLQKdyndyiKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLK----KKIEE-----YSKNIERMSAFIS 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  561 VTELEAQLKAEQQKvAEREKVMQEKAQLQEQLlaleETLQITKGSL---EEEKHRTADALAEQQRC-------------- 623
Cdd:PRK01156  395 EILKIQEIDPDAIK-KELNEINVKLQDISSKV----SSLNQRIRALrenLDELSRNMEMLNGQSVCpvcgttlgeeksnh 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  624 VTKMEAESRSLMEQR----EQEQKALEQEKAGRKGLEARLQQlEEARQAET-----EALRRELAEATASQHR---AESES 691
Cdd:PRK01156  470 IINHYNEKKSRLEEKireiEIEVKDIDEKIVDLKKRKEYLES-EEINKSINeynkiESARADLEDIKIKINElkdKHDKY 548


                  ....*....
gi 344240178  692 EQLIREVES 700
Cdd:PRK01156  549 EEIKNRYKS 557
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 437-542 1.63e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 44.30  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  437 LRQQVEQLssslklkEQQLEEAAKDQEAARQDHAQQLaivaEAREASLRER-DAARQQLETlEKEKAAKLESLQQQLEAA 515
Cdd:COG0542   416 LERRLEQL-------EIEKEALKKEQDEASFERLAEL----RDELAELEEElEALKARWEA-EKELIEEIQELKEELEQR 483

                          90       100
                  ....*....|....*....|....*..
gi 344240178  516 NEARDSVQTSVTQVQQEKAELSQKIEE 542
Cdd:COG0542   484 YGKIPELEKELAELEEELAELAPLLRE 510
PRK09039 PRK09039
peptidoglycan -binding protein;
1018-1159 1.66e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.42  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1018 LRAEVSKLEQQCQQQKQQVEGLTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSK 1097
Cdd:PRK09039   44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEGRAGELAQ 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1098 AEEEWKAQVARGQQEAERKSSLISSLEEEVSILNR--QVLEKEGESKELK------RLVVAESEKSQKLE 1159
Cdd:PRK09039  124 ELDSEKQVSARALAQVELLNQQIAALRRQLAALEAalDASEKRDRESQAKiadlgrRLNVALAQRVQELN 193
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
 1189-1534 1.74e-03

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 44.17  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1189 SLREEVEKQRvisenLRQELTSQAEraEELG------QELKaWQEKFFQKEQalSALQLEHTSTQALVSELLPAKHLCQQ 1262
Cdd:pfam15818    8 SLLEALEELR-----MRREAETQYE--EQIGkiivetQELK-WQKETLQNQK--ETLAKQHKEAMAVFKKQLQMKMCALE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1263 LQAEQAAAEKRHRE-EIEQSKQAAGGLRAELMRAQRelgelgplrqKVAEQERAAQQLRAEKASYAEQLSMLKKAHGLLA 1341
Cdd:pfam15818   78 EEKGKYQLATEIKEkEIEGLKETLKALQVSKYSLQK----------KVSEMEQKLQLHLLAKEDHHKQLNEIEKYYATIT 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1342 EENRGLGERanlgrqflEVELDQAREKYVQ---ELAAVRTDAETHLAEMRQEAQSTTREL--EVMTAKYegakvKVLEE- 1415
Cdd:pfam15818  148 GQFGLVKEN--------HGKLEQNVQEAIQlnkRLSALNKKQESEICSLKKELKKVTSDLikSKVTCQY-----KMGEEn 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1416 ------RQRFQEERQKLTAQVeELSKKLTEydQASKVQQQKLK---AFQAQGGESQQEVQ---RLQAQLNELQTQLSQKE 1483
Cdd:pfam15818  215 inltikEQKFQELQERLNMEL-ELNKKINE--EITHIQEEKQDiiiSFQHMQQLLQQQTQantEMEAELKALKENNQTLE 291

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  1484 QAAEhykLQMEKAKTHYDA----KKQQNQELQDQLRDLEQLQKENKELRAEAERL 1534
Cdd:pfam15818  292 RDNE---LQREKVKENEEKflnlQNEHEKALGTWKKHVEELNGEINEIKNELSSL 343
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 530-794 1.78e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 43.26  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   530 QQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQK----VAEREKVMQEKAQLQEQLLALEETLQITKGS 605
Cdd:pfam15905   65 SQKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKlnaaVREKTSLSASVASLEKQLLELTRVNELLKAK 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   606 LEEEKHRTadalaeqqrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLE---EARQAETEALRRELAEATA 682
Cdd:pfam15905  145 FSEDGTQK------------KMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQknlEHSKGKVAQLEEKLVSTEK 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   683 SQHRAESESEQLIREVEswqkrfeaRQQEEARYSAMIQEQLAALKGDHEKAGQEAQE-----EAVEVHGEGQIGEQQSPL 757
Cdd:pfam15905  213 EKIEEKSETEKLLEYIT--------ELSCVSEQVEKYKLDIAQLEELLKEKNDEIESlkqslEEKEQELSKQIKDLNEKC 284

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 344240178   758 AQLHTTLARALQQVKEKEvraQKLADDLTTLQEKMAS 794
Cdd:pfam15905  285 KLLESEKEELLREYEEKE---QTLNAELEELKEKLTL 318
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 947-1484 1.80e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.04  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   947 QELAKLRGQEAAQRT-ELKELQQTLEHLKTQLVKKEKE-QHPAGSTGGEEASAPEAQletvrKTEAPDPEVEALRAEVSK 1024
Cdd:pfam10174  170 KGLPKKSGEEDWERTrRIAEAEMQLGHLEVLLDQKEKEnIHLREELHRRNQLQPDPA-----KTKALQTVIEMKDTKISS 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1025 LEQQCQQQKQQVEGLTHSLESERASRAEQDKALET-------LQGQLEEKTQELGHSQAASASAQRELTALHAKAQDHSK 1097
Cdd:pfam10174  245 LERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVykshskfMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQ 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1098 AEEEWKAQVARGQQEAerkssliSSLEEEVSILNRQVLEKEG----ESKELKRLVVAESEKSQKL----------EERLR 1163
Cdd:pfam10174  325 HIEVLKESLTAKEQRA-------AILQTEVDALRLRLEEKESflnkKTKQLQDLTEEKSTLAGEIrdlkdmldvkERKIN 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1164 LLQ--VETASSSARAAERS-SALREEVQSLREE---------------VEKQRVIsENLRQELTSQ-AERAEELGQELKA 1224
Cdd:pfam10174  398 VLQkkIENLQEQLRDKDKQlAGLKERVKSLQTDssntdtalttleealSEKERII-ERLKEQREREdRERLEELESLKKE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1225 WQEKffqkEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRE------ 1298
Cdd:pfam10174  477 NKDL----KEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAeeavrt 552

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1299 ----LGELGPLRQKV-----------AEQERAAQQLR---AEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV 1360
Cdd:pfam10174  553 npeiNDRIRLLEQEVarykeesgkaqAEVERLLGILReveNEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKK 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1361 E-LDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTE 1439
Cdd:pfam10174  633 KgAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAERRKQLEEILEMKQE 712

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 344240178  1440 YDQASKVQQQK----LKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQ 1484
Cdd:pfam10174  713 ALLAAISEKDAnialLELSSSKKKKTQEEVMALKREKDRLVHQLKQQTQ 761
PRK11281 PRK11281
mechanosensitive channel MscK;
139-573 1.81e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.13  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  139 DAQIAMMQQRIDHLALLNEKQAASSQESRELEELrgknESltvRLHETLKQCQNLKteknqmdrkiSQLSEENGDLsfkv 218
Cdd:PRK11281   93 PAKLRQAQAELEALKDDNDEETRETLSTLSLRQL----ES---RLAQTLDQLQNAQ----------NDLAEYNSQL---- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  219 refashlqqlqgafndlteehnkASQewaekQTHLE---KELSTALQDkkyLEEKNEILQ-GKLSQLEERASQQCESPAQ 294
Cdd:PRK11281  152 -----------------------VSL-----QTQPEraqAALYANSQR---LQQIRNLLKgGKVGGKALRPSQRVLLQAE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  295 EkgevlgDALQLETLKQEaaKLAAHNTQLQarietlDCERSQQEaqLLAERghfeeeKQQLASLIADLQSSIS--NLSQA 372
Cdd:PRK11281  201 Q------ALLNAQNDLQR--KSLEGNTQLQ------DLLQKQRD--YLTAR------IQRLEHQLQLLQEAINskRLTLS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  373 KEELEQASQAQGAQLTAQ---VASLTALNTTLQQ---QQDQELASLKEQakkeQAQMVQSLQEQEQAAQGLRQQVEQLSS 446
Cdd:PRK11281  259 EKTVQEAQSQDEAARIQAnplVAQELEINLQLSQrllKATEKLNTLTQQ----NLRVKNWLDRLTQSERNIKEQISVLKG 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  447 SLKL-----KEQQ-LEEAAKDQEAARQdhaqqlaIvaeareASLR----ERDAARQQLETLEkEKAAKLESLQQQleaan 516
Cdd:PRK11281  335 SLLLsrilyQQQQaLPSADLIEGLADR-------I------ADLRleqfEINQQRDALFQPD-AYIDKLEAGHKS----- 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178  517 EARDSVQTSVTQVQQEKAE-LSQKIEELHACIEAA---HQEQRQAQAHVTELEAQLkaEQQ 573
Cdd:PRK11281  396 EVTDEVRDALLQLLDERRElLDQLNKQLNNQLNLAinlQLNQQQLLSVSDSLQSTL--TQQ 454
DUF4175 pfam13779
Domain of unknown function (DUF4175);
210-511 1.85e-03

Domain of unknown function (DUF4175);


Pssm-ID: 463981 [Multi-domain]  Cd Length: 833  Bit Score: 43.82  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   210 ENGDLSFKVREfashLQQLQGAFNDLTEehNKASQEWAEKQThleKELSTALQDKkyleekneilqgkLSQLEERASQQC 289
Cdd:pfam13779  480 EDGDLSDAERR----LRAAQERLSEALE--RGASDEEIAKLM---QELREALDDY-------------MQALAEQAQQNP 537

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   290 ESPAQ----EKGEVLGDALQ-----LETLKQEAAKLAAHN--TQLQARIETLDCERSQQEAQLLAERGHfeEEKQQLASL 358
Cdd:pfam13779  538 QDLQQpddpNAQEMTQQDLQrmldrIEELARSGRRAEAQQmlSQLQQMLENLQAGQPQQQQQQGQSEMQ--QAMDELGDL 615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   359 IADlQSSISNlsQAKEELEQASQAQGAQltaqvasltalnttlQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLR 438
Cdd:pfam13779  616 LRE-QQQLLD--ETFRQLQQQGGQQQGQ---------------PGQQGQQGQGQQPGQGGQQPGAQMPPQGGAEALGDLA 677

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178   439 QQVEQLSSslKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREAsLRERDAAR---QQLETLE--KEKAAKL-ESLQQQ 511
Cdd:pfam13779  678 ERQQALRR--RLEELQDELKELGGKEPGQALGDAGRAMRDAEEA-LGQGDLAGavdAQGRALEalRKGAQQLaEAMQQQ 753
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 480-612 1.88e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 41.84  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   480 REASLRERDAARQQ-----LETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQ 554
Cdd:pfam08614   15 RTALLEAENAKLQSepesvLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRGELAQRLVDLNEELQELEKKL 94

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178   555 RQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHR 612
Cdd:pfam08614   95 REDERRLAALEAERAQLEEKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRK 152
RNase_Y_N pfam12072
RNase Y N-terminal region;
474-597 1.97e-03

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 42.18  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   474 AIVAEAREASLRERDAARQQLETLEKEK--AAKLESLQQQLEAANEARDS---VQTSVTQVQQEKAELSQKIEELhacie 548
Cdd:pfam12072   27 AKIGSAEELAKRIIEEAKKEAETKKKEAllEAKEEIHKLRAEAERELKERrneLQRQERRLLQKEETLDRKDESL----- 101

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 344240178   549 aahqEQRQAQahVTELEAQLKAEQQKVAEREKVMQEKaqLQEQLLALEE 597
Cdd:pfam12072  102 ----EKKEES--LEKKEKELEAQQQQLEEKEEELEEL--IEEQRQELER 142
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 290-613 2.02e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.59  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   290 ESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQlqARIETLDCERSQQEAQLLAERGHFEEEKqqlaslIADLQSSISNL 369
Cdd:pfam09731  114 EAKAQLPKSEQEKEKALEEVLKEAISKAESATA--VAKEAKDDAIQAVKAHTDSLKEASDTAE------ISREKATDSAL 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   370 SQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSL---QEQEQAAQGLRQQVEQLSS 446
Cdd:pfam09731  186 QKAEALAEKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKlvdQYKELVASERIVFQQELVS 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   447 -----SLKLKEqqLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLEtLEKEKAAKLESLQQQLEAANEARDS 521
Cdd:pfam09731  266 ifpdiIPVLKE--DNLLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERA-LEKQKEELDKLAEELSARLEEVRAA 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   522 vqtsvtQVQQEKAELSQKIEELHACIEAAHQEQ--RQAQAH-------VTELEAQLKAEQQKVAErEKVMQEKA----QL 588
Cdd:pfam09731  343 ------DEAQLRLEFEREREEIRESYEEKLRTEleRQAEAHeehlkdvLVEQEIELQREFLQDIK-EKVEEERAgrllKL 415

                          330       340
                   ....*....|....*....|....*..
gi 344240178   589 QEQLLALEETLQITKG--SLEEEKHRT 613
Cdd:pfam09731  416 NELLANLKGLEKATSShsEVEDENRKA 442
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 167-512 2.03e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 43.52  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   167 RELEELRGKNESLTVRLHET---------LKQC--------QNLKTEKNQMD------RKISQLSEEN-------GDLSF 216
Cdd:pfam05622   94 KEVLELQHRNEELTSLAEEAqalkdemdiLRESsdkvkkleATVETYKKKLEdlgdlrRQVKLLEERNaeymqrtLQLEE 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   217 KVREFASHLQQLQGAFNDLTEEHNKASQE------WA-------EKQTHLEKELSTALQDKKYLEEKNEILQ-GKLSQLE 282
Cdd:pfam05622  174 ELKKANALRGQLETYKRQVQELHGKLSEEskkadkLEfeykkleEKLEALQKEKERLIIERDTLRETNEELRcAQLQQAE 253

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   283 ERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAE---RGHFEEEKQQLAsli 359
Cdd:pfam05622  254 LSQADALLSPSSDPGDNLAAEIMPAEIREKLIRLQHENKMLRLGQEGSYRERLTELQQLLEDanrRKNELETQNRLA--- 330

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   360 adlQSSISNLSQAKEELEQASQAQGAQltAQVASLtaLNTTLQQQQDQeLASLKEQAKKEQAQmvqsLQEQEQAA-QGLR 438
Cdd:pfam05622  331 ---NQRILELQQQVEELQKALQEQGSK--AEDSSL--LKQKLEEHLEK-LHEAQSELQKKKEQ----IEELEPKQdSNLA 398

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   439 QQVEQLSSSLKLKEQQL----EEAAKDQEAARQ-----DHAQQLAIVAEAR--EASLRERDAARQQLETlEKEKAAKLES 507
Cdd:pfam05622  399 QKIDELQEALRKKDEDMkameERYKKYVEKAKSviktlDPKQNPASPPEIQalKNQLLEKDKKIEHLER-DFEKSKLQRE 477


                   ....*
gi 344240178   508 LQQQL 512
Cdd:pfam05622  478 QEEKL 482
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 377-652 2.05e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 43.30  E-value: 2.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   377 EQASQAQGAQLTAQVASLTALNTTLQQQQD-----QELASLKEQAKKEQAQMvqslQEQEQAAQglrqqveqlssslklk 451
Cdd:TIGR02794   32 GGGAEIIQAVLVDPGAVAQQANRIQQQKKPaakkeQERQKKLEQQAEEAEKQ----RAAEQARQ---------------- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   452 eQQLEEAAKDQEAARQdhaqqlaiVAEAREASLRERDAARQQLETLEKEKAAKleslqqqLEAANEardsvqtsvtqvQQ 531
Cdd:TIGR02794   92 -KELEQRAAAEKAAKQ--------AEQAAKQAEEKQKQAEEAKAKQAAEAKAK-------AEAEAE------------RK 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   532 EKAELSQKIEElhaciEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKH 611
Cdd:TIGR02794  144 AKEEAAKQAEE-----EAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAA 218

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 344240178   612 RTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGR 652
Cdd:TIGR02794  219 AAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGS 259
PRK12704 PRK12704
phosphodiesterase; Provisional
 273-430 2.09e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  273 ILQGKLSQLEERASQQCESpAQEKGEVLGDALQLEtLKQEAAKLaahNTQLQARIETLDCERSQQEAQLLAERGHFEEEK 352
Cdd:PRK12704   28 IAEAKIKEAEEEAKRILEE-AKKEAEAIKKEALLE-AKEEIHKL---RNEFEKELRERRNELQKLEKRLLQKEENLDRKL 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  353 QQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTAL-NTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQ 430
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERIsGLTAEEAKEILLEKVEEEARHEAAVLIKEIEEE 181
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1387-1565 2.20e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.57  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1387 MRQEAQSTTRELEVMTAKYEGAKVKVLE---------ERQRFQEERQKLTAQVEELSKKlteyDQASKVQQQKLkafqAQ 1457
Cdd:pfam17380  301 LRQEKEEKAREVERRRKLEEAEKARQAEmdrqaaiyaEQERMAMERERELERIRQEERK----RELERIRQEEI----AM 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1458 GGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQmekakthydaKKQQNQELQDQLRDLEQLQKENKELRA-EAERLGR 1536
Cdd:pfam17380  373 EISRMRELERLQMERQQKNERVRQELEAARKVKIL----------EEERQRKIQQQKVEMEQIRAEQEEARQrEVRRLEE 442

                          170       180
                   ....*....|....*....|....*....
gi 344240178  1537 ELQQAGLKTKEAEQACRHLSAQVRSLEAQ 1565
Cdd:pfam17380  443 ERAREMERVRLEEQERQQQVERLRQQEEE 471
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 530-638 2.29e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 43.79  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  530 QQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLAL-EETLQITKGSLEE 608
Cdd:PRK11448  141 ENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELE---EKQQELEAQLEQLqEKAAETSQERKQK 217

                          90       100       110
                  ....*....|....*....|....*....|
gi 344240178  609 EKHRTADALAEqqrcVTKMEAESRSLMEQR 638
Cdd:PRK11448  218 RKEITDQAAKR----LELSEEETRILIDQQ 243
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
234-478 2.36e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 43.53  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  234 DLTEEHNKASQEWAEkqthLEKELSTALQDKKYLEEKNEILQGKLSQLEErasqqcespAQ-EKGEvlgdalqLETLKQE 312
Cdd:COG0497   155 ELLEEYREAYRAWRA----LKKELEELRADEAERARELDLLRFQLEELEA---------AAlQPGE-------EEELEEE 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  313 AAKLAaHNTQLQarietldcERSQQEAQLLAER--------GHFEEEKQQLASLIADLQSSISNLSQAKEELEQAS---Q 381
Cdd:COG0497   215 RRRLS-NAEKLR--------EALQEALEALSGGeggaldllGQALRALERLAEYDPSLAELAERLESALIELEEAAselR 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  382 AQGAQLTAQVASLTALNTTLQQQQD---------QELASLKEQAKKEQAQmvqsLQEQEQAAQGLRQQVEQLssslklkE 452
Cdd:COG0497   286 RYLDSLEFDPERLEEVEERLALLRRlarkygvtvEELLAYAEELRAELAE----LENSDERLEELEAELAEA-------E 354

                         250       260
                  ....*....|....*....|....*...
gi 344240178  453 QQLEEAAKDQEAARQDHAQQL--AIVAE 478
Cdd:COG0497   355 AELLEAAEKLSAARKKAAKKLekAVTAE 382
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 401-722 2.57e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 42.50  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   401 LQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEar 480
Cdd:pfam17045   11 LMKQIDIMVAHKKSEWEGQTRALETRLDIREEELLSARNTLERKHKEIGLLRQQLEELEKGKQELVAKYEQQLQKLQE-- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   481 easlrERDAARQQLETLEKekaakleslqQQLEAANEARDSVQtsvtQVQQEKAELSQKIEELHACIEAAHQEQRQAQAH 560
Cdd:pfam17045   89 -----ELSKLKRSYEKLQR----------KQLKEAREEAKSRE----EDRSELSRLNGKLEEFRQKSLEWEQQRLQYQQQ 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   561 VTELEAQLKAeqqkVAEREKVMQEKAQLQEqllaleetlqitkgsLEEEKHRTADALAEQQRCVTKMEAESRSLmeqreq 640
Cdd:pfam17045  150 VASLEAQRKA----LAEQSSLIQSAAYQVQ---------------LEGRKQCLEASQSEIQRLRSKLERAQDSL------ 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   641 eqkaleqekagrkglearlqqleEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQ 720
Cdd:pfam17045  205 -----------------------CAQELELERLRMRVSELGDSNRKLLEEQQRLLEELRMSQRQLQVLQNELMELKATLQ 261


                   ..
gi 344240178   721 EQ 722
Cdd:pfam17045  262 SQ 263
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
403-751 2.60e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 43.10  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  403 QQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREA 482
Cdd:COG3064     6 EEKAAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEEAREAKAEAEQRAAELAAEAAKKLAEAEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  483 SLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEElhaciEAAHQEQRQAQAHVT 562
Cdd:COG3064    86 AAEAEKKAAAEKAKAAKEAEAAAAAEKAAAAAEKEKAEEAKRKAEEEAKRKAEEERKAAE-----AEAAAKAEAEAARAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  563 ELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQ 642
Cdd:COG3064   161 AAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEAT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  643 KALEQEKAGRKGLEARLQQLEEARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQ 722
Cdd:COG3064   241 EEAALGGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLAA 320

                         330       340
                  ....*....|....*....|....*....
gi 344240178  723 LAALKGDHEKAGQEAQEEAVEVHGEGQIG 751
Cdd:COG3064   321 AAAAGALVVRGGGAASLEAALSLLAAGAA 349
HpsJ_fam NF038305
HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the ...
 320-449 2.61e-03

HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the biosynthesis or secretion of an extracellular polysaccharide shared by many Cyanobacteria.


Pssm-ID: 468465 [Multi-domain]  Cd Length: 230  Bit Score: 42.19  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  320 NTQLQARIETldcERSQQEAQLlaerghfeeeKQQLASLIAdlQSSISNLSQ-AKEELEQASQAQGAQLTAQVASLtaln 398
Cdd:NF038305  106 STQALQQINQ---QAGQQETQL----------QQQLNQLQA--QTSPQQLNQlLKSEQKQGQALASGQLPEEQKEQ---- 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  399 ttLQQQQDQELAsLKEQAKKEQAQMVQSLQEQEQaaqglRQQVEQLSSSLK 449
Cdd:NF038305  167 --LQQFKSNPQA-LDKFLAQQLTQIRTQAEEAEK-----QARLEALKSSLR 209
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 486-580 2.63e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 40.64  E-value: 2.63e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    486 ERDAARQQLETLEKEKAAKLESLQQQLEAANEA--RDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTE 563
Cdd:smart00935   15 AGKAAQKQLEKEFKKRQAELEKLEKELQKLKEKlqKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQ 94

                            90
                    ....*....|....*...
gi 344240178    564 -LEAQLKAEQQKVAEREK 580
Cdd:smart00935   95 kILDKINKAIKEVAKKKG 112
PRK12704 PRK12704
phosphodiesterase; Provisional
 1400-1550 2.65e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1400 VMTAKYEGAK---VKVLEERQRFQEE--RQKLTAQVEELSKKLTEYDQASKvqqqklkafqaqggESQQEVQRLQAQLNE 1474
Cdd:PRK12704   28 IAEAKIKEAEeeaKRILEEAKKEAEAikKEALLEAKEEIHKLRNEFEKELR--------------ERRNELQKLEKRLLQ 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1475 LQTQLSQKEQAAEhyklqmekakthydakkQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQQ-----AGLKTKEAE 1549
Cdd:PRK12704   94 KEENLDRKLELLE-----------------KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEAK 156


                  .
gi 344240178 1550 Q 1550
Cdd:PRK12704  157 E 157
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 336-495 2.70e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  336 QQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEqasqaqgaqltAQVASLTALNTTLQQQQDQeLASLKE- 414
Cdd:COG1579    24 HRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLE-----------LEIEEVEARIKKYEEQLGN-VRNNKEy 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  415 -QAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQ 493
Cdd:COG1579    92 eALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171


                  ..
gi 344240178  494 LE 495
Cdd:COG1579   172 IP 173
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2274-2376 2.75e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2274 LNLAIRLGHEAITDVLL---ANIKFDFRQIHEALLVAVDTNQPAVVRCLLARlerekgrkvdtksfslaffdssIDGSRF 2350
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLengADANLQDKNGRTALHLAAKNGHLEIVKLLLEH----------------------ADVNLK 58

                           90       100
                   ....*....|....*....|....*.
gi 344240178  2351 APGVTPLTLACQKDLYEIAQLLMDQG 2376
Cdd:pfam12796   59 DNGRTALHYAARSGHLEIVKLLLEKG 84
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1417-1551 2.77e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 42.87  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1417 QRFQEERQKLTA-QVEELSKKLTEYDQasKVQQQKLKAFQAQGGESQQEVQRLQAQLnelqtqlsQKEQAAEHYKLQMEK 1495
Cdd:PRK09510   75 KRAEEQRKKKEQqQAEELQQKQAAEQE--RLKQLEKERLAAQEQKKQAEEAAKQAAL--------KQKQAEEAAAKAAAA 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178 1496 AKTHYDAKKQQNQELQDQLRDlEQLQKENKELRAEAERLGRELQQAGLKTKEAEQA 1551
Cdd:PRK09510  145 AKAKAEAEAKRAAAAAKKAAA-EAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEA 199
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 349-577 2.78e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 42.29  E-value: 2.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   349 EEEKQQLASLIADLQSSISNLSQAKEELEQASQAQG------AQLTAQVASLTALNTTLQQQQDQELASLK-EQAKKEQA 421
Cdd:pfam12795    9 KLDEAAKKKLLQDLQQALSLLDKIDASKQRAAAYQKalddapAELRELRQELAALQAKAEAAPKEILASLSlEELEQRLL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   422 QMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQqlaivaeAREASLRERDAARQQLETLEKEK 501
Cdd:pfam12795   89 QTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQRLQQIRNRLNG-------PAPPGEPLSEAQRWALQAELAAL 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178   502 AAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQ-RQAQAHVTELEAQLKAEQQKVAE 577
Cdd:pfam12795  162 KAQIDMLEQELLSNNNRQDLLKARRDLLTLRIQRLEQQLQALQELLNEKRLQEaEQAVAQTEQLAEEAAGDHPLVQQ 238
PRK09039 PRK09039
peptidoglycan -binding protein;
1463-1590 2.83e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 42.65  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1463 QEVQRLQAQLNELQTQLSQKEQAaehykLQMEKAKTHydAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGREL-QQA 1541
Cdd:PRK09039   46 REISGKDSALDRLNSQIAELADL-----LSLERQGNQ--DLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAeGRA 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 344240178 1542 GLKTKEAEQAcRHLSAQVRS----LEAQVAHADQQLRDLgkfQVATDALKSRE 1590
Cdd:PRK09039  119 GELAQELDSE-KQVSARALAqvelLNQQIAALRRQLAAL---EAALDASEKRD 167
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 523-805 2.83e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.50  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQA-QAHVTELEAQlKAEQQKVAEREKVMQE----KAQLQEQLLALEE 597
Cdd:PRK10929   15 WGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEAlQSALNWLEER-KGSLERAKQYQQVIDNfpklSAELRQQLNNERD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  598 TLQITKGSLeeekhrTADALaEQQrcvtkMEAESRSLMEQREQEQKalEQEKAGR--KGLEARLQQLEEARQAETEALRR 675
Cdd:PRK10929   94 EPRSVPPNM------STDAL-EQE-----ILQVSSQLLEKSRQAQQ--EQDRAREisDSLSQLPQQQTEARRQLNEIERR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  676 ---------ELAEATASQHRAESESEQ-LIREVE----SWQKRFE-ARQQEE--ARYSAMIQEQLAALKGDHEKAGQEAQ 738
Cdd:PRK10929  160 lqtlgtpntPLAQAQLTALQAESAALKaLVDELElaqlSANNRQElARLRSElaKKRSQQLDAYLQALRNQLNSQRQREA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178  739 EEAVEvHGEgQIGEQ-----QSPLAQLHT--TLARALQQvkekevRAQKLadDLTTLQEKMAS--TSKVAACLKTL 805
Cdd:PRK10929  240 ERALE-STE-LLAEQsgdlpKSIVAQFKInrELSQALNQ------QAQRM--DLIASQQRQAAsqTLQVRQALNTL 305
Tropomyosin_1 pfam12718
Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and ...
 504-649 2.84e-03

Tropomyosin like; This family is a set of eukaryotic tropomyosins. Within the yeast Tpm1 and Tpm2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpm1p spans five. Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis. The family also contains higher eukaryote Tpm3 members.


Pssm-ID: 403808 [Multi-domain]  Cd Length: 142  Bit Score: 40.75  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   504 KLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEqrqaqahVTELEAQLKAEQQKVAEREKVMQ 583
Cdd:pfam12718    1 KMNSLKLEAENAQERAEELEEKVKELEQENLEKEQEIKSLTHKNQQLEEE-------VEKLEEQLKEAKEKAEESEKLKT 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178   584 EKAQLQEQLLALEETLQITKGSLEE--EKHRTADALAEQ-QRCVTKMEAESRSLMEQREQEQKALEQEK 649
Cdd:pfam12718   74 NNENLTRKIQLLEEELEESDKRLKEttEKLRETDVKAEHlERKVQALEQERDEWEKKYEELEEKYKEAK 142
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 446-648 2.86e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.07  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   446 SSLKLKEQQLEEAAKDQEAARQdhaqqlAIVAEAREAslrERDAARQQLETLEKEKAAK-LESLQQQLEAANEARDSVQT 524
Cdd:pfam05262  178 SDKKVVEALREDNEKGVNFRRD------MTDLKERES---QEDAKRAQQLKEELDKKQIdADKAQQKADFAQDNADKQRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   525 SVTQVQQEKAELSQKieelhACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAqlqeqllalEETLQITKG 604
Cdd:pfam05262  249 EVRQKQQEAKNLPKP-----ADTSSPKEDKQVAENQKREIEKAQIEIKKNDEEALKAKDHKA---------FDLKQESKA 314

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 344240178   605 SLEEEKHRTADAlaeqQRCVTKMEAESRSLMEQREQEQKALEQE 648
Cdd:pfam05262  315 SEKEAEDKELEA----QKKREPVAEDLQKTKPQVEAQPTSLNED 354
BAR cd07307
The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects ...
 366-569 3.09e-03

The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. Mutations in BAR containing proteins have been linked to diseases and their inactivation in cells leads to altered membrane dynamics. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysins and endophilins, among others. BAR domains are also frequently found alongside domains that determine lipid specificity, such as the Pleckstrin Homology (PH) and Phox Homology (PX) domains which are present in beta centaurins (ACAPs and ASAPs) and sorting nexins, respectively. A FES-CIP4 Homology (FCH) domain together with a coiled coil region is called the F-BAR domain and is present in Pombe/Cdc15 homology (PCH) family proteins, which include Fes/Fes tyrosine kinases, PACSIN or syndapin, CIP4-like proteins, and srGAPs, among others. The Inverse (I)-BAR or IRSp53/MIM homology Domain (IMD) is found in multi-domain proteins, such as IRSp53 and MIM, that act as scaffolding proteins and transducers of a variety of signaling pathways that link membrane dynamics and the underlying actin cytoskeleton. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The I-BAR domain induces membrane protrusions in the opposite direction compared to classical BAR and F-BAR domains, which produce membrane invaginations. BAR domains that also serve as protein interaction domains include those of arfaptin and OPHN1-like proteins, among others, which bind to Rac and Rho GAP domains, respectively.


Pssm-ID: 153271 [Multi-domain]  Cd Length: 194  Bit Score: 41.66  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  366 ISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQaaqGLRQQVEQLS 445
Cdd:cd07307     9 LKKLIKDTKKLLDSLKELPAAAEKLSEALQELGKELPDLSNTDLGEALEKFGKIQKELEEFRDQLEQ---KLENKVIEPL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  446 SSLKLKE-QQLEEAAKDQEAARQDHaqqlaivaeareaslrerDAARQQLETLEK--EKAAKLESLQQQLEAA----NEA 518
Cdd:cd07307    86 KEYLKKDlKEIKKRRKKLDKARLDY------------------DAAREKLKKLRKkkKDSSKLAEAEEELQEAkekyEEL 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  519 RDSVQTSVTQVQQEKAELSQKIeeLHACIEAahqeQRQAQAHVTELEAQLK 569
Cdd:cd07307   148 REELIEDLNKLEEKRKELFLSL--LLSFIEA----QSEFFKEVLKILEQLL 192
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1380-1593 3.16e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1380 AETHLAEMRQEAQSTTRELEvmtakyegakvKVLEERQRFQEERQKLTAQVEELSKKLTEydqaskvQQQKLKAFQAQGG 1459
Cdd:COG3883    14 ADPQIQAKQKELSELQAELE-----------AAQAELDALQAELEELNEEYNELQAELEA-------LQAEIDKLQAEIA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1460 ESQQEVQRLQAQLNElQTQLSQKEQAAEHYKLQMEKAKTHYDA----------KKQQNQELQDQLRDLEQLQKENKELRA 1529
Cdd:COG3883    76 EAEAEIEERREELGE-RARALYRSGGSVSYLDVLLGSESFSDFldrlsalskiADADADLLEELKADKAELEAKKAELEA 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 344240178 1530 EAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQK 1593
Cdd:COG3883   155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAA 218
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1175-1499 3.22e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1175 RAAERSSALREEVQSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELL 1254
Cdd:COG4372    42 KLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1255 PAKHLCQQLQAEQAAAEKRHREEIEQSKQAAGGLRAELMRAQRELGELGPLRQKVAEQE--RAAQQLRAEKASYAEQLSM 1332
Cdd:COG4372   122 KERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEaeQALDELLKEANRNAEKEEE 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1333 LKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKV 1412
Cdd:COG4372   202 LAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIA 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1413 LEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQ 1492
Cdd:COG4372   282 ALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSK 361


                  ....*..
gi 344240178 1493 MEKAKTH 1499
Cdd:COG4372   362 GAEAGVA 368
DUF4175 pfam13779
Domain of unknown function (DUF4175);
1290-1564 3.28e-03

Domain of unknown function (DUF4175);


Pssm-ID: 463981 [Multi-domain]  Cd Length: 833  Bit Score: 43.05  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1290 AELMRAQRELGElgPLRQKVAEQE--RAAQQLRAEKASYAEQLSmlKKAHGLLAEENRGLGERAN-LGRQFLEVELDQar 1366
Cdd:pfam13779  489 RRLRAAQERLSE--ALERGASDEEiaKLMQELREALDDYMQALA--EQAQQNPQDLQQPDDPNAQeMTQQDLQRMLDR-- 562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1367 ekyVQELAAV--RTDAETHLAEMRQ---EAQSTTRELEVMTAKyegakvkvlEERQRFQEERQKLTAQVEELSkklteyD 1441
Cdd:pfam13779  563 ---IEELARSgrRAEAQQMLSQLQQmleNLQAGQPQQQQQQGQ---------SEMQQAMDELGDLLREQQQLL------D 624

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1442 QA-SKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYklqmekakthydakkQQNQELQDQLRD-LEQ 1519
Cdd:pfam13779  625 ETfRQLQQQGGQQQGQPGQQGQQGQGQQPGQGGQQPGAQMPPQGGAEAL---------------GDLAERQQALRRrLEE 689

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1520 LQKENKELRAEAErlGRELQQAGLKTKEAEQACRH------LSAQVRSLEA 1564
Cdd:pfam13779  690 LQDELKELGGKEP--GQALGDAGRAMRDAEEALGQgdlagaVDAQGRALEA 738
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 497-578 3.43e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 43.02  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  497 LEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVA 576
Cdd:PRK11448  143 LLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSQERKQKRKEIT 222


                  ..
gi 344240178  577 ER 578
Cdd:PRK11448  223 DQ 224
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1395-1511 3.46e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.89  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1395 TRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQ--ASKVQQQKLKAFQAQgGESQQEVQRLQAQL 1472
Cdd:PRK00409  515 KEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEeeDKLLEEAEKEAQQAI-KEAKKEADEIIKEL 593

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 344240178 1473 NELQ--TQLSQKEQAAE----HYKLQMEKAKTHYDAKKQQNQELQ 1511
Cdd:PRK00409  594 RQLQkgGYASVKAHELIearkRLNKANEKKEKKKKKQKEKQEELK 638
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 453-556 3.46e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 43.02  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  453 QQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSvqtsvtQVQQE 532
Cdd:PRK11448  141 ENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAE------TSQER 214

                          90       100
                  ....*....|....*....|....
gi 344240178  533 KAELSQKIEELHACIEAAHQEQRQ 556
Cdd:PRK11448  215 KQKRKEITDQAAKRLELSEEETRI 238
DUF4201 pfam13870
Domain of unknown function (DUF4201); This is a family of coiled-coil proteins from eukaryotes. ...
 1420-1547 3.54e-03

Domain of unknown function (DUF4201); This is a family of coiled-coil proteins from eukaryotes. The function is not known.


Pssm-ID: 464008 [Multi-domain]  Cd Length: 177  Bit Score: 41.05  E-value: 3.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1420 QEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQaqggesqQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTH 1499
Cdd:pfam13870   48 QIENQALNEKIEERNKELKRLKLKVTNTVHALTHLK-------EKLHFLSAELSRLKKELRERQELLAKLRKELYRVKLE 120

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  1500 YDAKKQQNQELQDQ---------LRDLEQLQKENKELRAEAERLGRELQQAGLKTKE 1547
Cdd:pfam13870  121 RDKLRKQNKKLRQQggllhvpalLHDYDKTKAEVEEKRKSVKKLRRKVKILEMRIKE 177
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 459-741 3.60e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 42.72  E-value: 3.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   459 AKDQEAARQDHAQQLAivAEAREaSLRERDAARQqlETLEKEKAAKLESLQQQLEAANEARdsvQTSVTQVQQEKAELSQ 538
Cdd:pfam15558   15 ARHKEEQRMRELQQQA--ALAWE-ELRRRDQKRQ--ETLERERRLLLQQSQEQWQAEKEQR---KARLGREERRRADRRE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   539 KIEELhacieaaHQEQRQAQAhvtelEAQLKAEQQKVAEREKVMQEKAQLQEQLL-ALEETLQITKGSLEEEKHRTadal 617
Cdd:pfam15558   87 KQVIE-------KESRWREQA-----EDQENQRQEKLERARQEAEQRKQCQEQRLkEKEEELQALREQNSLQLQER---- 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   618 aEQQRCVTKMEAESRSLMEQREQEQKAL--------------EQEKAGRKG-LEARLQQLEEARQAETEALRRELAEata 682
Cdd:pfam15558  151 -LEEACHKRQLKEREEQKKVQENNLSELlnhqarkvlvdcqaKAEELLRRLsLEQSLQRSQENYEQLVEERHRELRE--- 226

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178   683 sqhRAESESEQLIReVESWQKRFEARQQEEARysAMIQEQLAALKGDHEKAGQEAQEEA 741
Cdd:pfam15558  227 ---KAQKEEEQFQR-AKWRAEEKEEERQEHKE--ALAELADRKIQQARQVAHKTVQDKA 279
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 2551-2779 3.61e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.49  E-value: 3.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2551 LFVAFLIFLTMPFLCIgYWLAPKSRLGHLLKIpvLKFLLHSASYLWFLIFLLGESLVMetqlstfkGRSQSVWETSLHMI 2630
Cdd:pfam08016   16 VFVVFFLYFVVEEILK-IRKHRPSYLRSVWNL--LDLAIVILSVVLIVLNIYRDFLAD--------RLIKSVEASPVTFI 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2631 WVTERSEWrtedpQFLAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGRMIDDMIRFMFILMIILTAFLCGLnniYVP 2710
Cdd:pfam08016   85 DFDRVAQL-----DNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFG---YLL 156

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  2711 Y-QETEKLGNFNETFQFLFWTMFGMEEHTVVdmpqFLVPEFVGRALYGIFTIVMVIVLLNMLIAMITNSF 2779
Cdd:pfam08016  157 FgTQAPNFSNFVKSILTLFRTILGDFGYNEI----FSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSY 222
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
532-731 3.63e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 41.73  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  532 EKAE-----LSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmqEKAQlqeqlLALEetlqitKGsl 606
Cdd:COG1842    19 DKAEdpekmLDQAIRDMEEDLVEARQALAQVIANQKRLERQLEELEAEAEKWE----EKAR-----LALE------KG-- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  607 EEEKHRtaDALAEQQrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEeaRQAETEALRRELAEATASQHR 686
Cdd:COG1842    82 REDLAR--EALERKA----ELEAQAEALEAQLAQLEEQVEKLKEALRQLESKLEELK--AKKDTLKARAKAAKAQEKVNE 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 344240178  687 A-----ESESEQLIREVESWQKRFEARQQ--EEARYSAMIQEQLAALKGDHE 731
Cdd:COG1842   154 AlsgidSDDATSALERMEEKIEEMEARAEaaAELAAGDSLDDELAELEADSE 205
Nup88 pfam10168
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...
 1366-1523 3.64e-03

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.


Pssm-ID: 462975 [Multi-domain]  Cd Length: 713  Bit Score: 43.11  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1366 REKYV--QELAavrtdaethlaemRQEAQSTTRELEVMtakyegaKVKVLEERQRFQEERQKLTAQVEELSKKLTE--YD 1441
Cdd:pfam10168  545 REEYLkkHDLA-------------REEIQKRVKLLKLQ-------KEQQLQELQSLEEERKSLSERAEKLAEKYEEikDK 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1442 QASKVQQQK--LKAFQAQ-------GGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAK--------- 1503
Cdd:pfam10168  605 QEKLMRRCKkvLQRLNSQlpvlsdaEREMKKELETINEQLKHLANAIKQAKKKMNYQRYQIAKSQSIRKKSslslsekqr 684

                          170       180
                   ....*....|....*....|....*..
gi 344240178  1504 -------KQQNQELQDQLRDLEQLQKE 1523
Cdd:pfam10168  685 ktikeilKQLGSEIDELIKQVKDINKH 711
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 490-679 3.83e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 42.27  E-value: 3.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   490 ARQQLETLEKEKAAK----LESLQQQLEAaneaRDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRqaqahvtELE 565
Cdd:pfam02841  156 ERDKLEAKYNQVPRKgvkaEEVLQEFLQS----KEAVEEAILQTDQALTAKEKAIEAERAKAEAAEAEQE-------LLR 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   566 AQLKAEQQKVAEREKVMQE-KAQLQEQllaleetlqitkgsLEEEKHrtadalaeqqrcvtKMEAESRSLMEQREQEQKA 644
Cdd:pfam02841  225 EKQKEEEQMMEAQERSYQEhVKQLIEK--------------MEAERE--------------QLLAEQERMLEHKLQEQEE 276

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 344240178   645 LeqekagrkglearlqqLEEARQAETEALRRELAE 679
Cdd:pfam02841  277 L----------------LKEGFKTEAESLQKEIQD 295
PRK10920 PRK10920
putative uroporphyrinogen III C-methyltransferase; Provisional
 1461-1519 3.85e-03

putative uroporphyrinogen III C-methyltransferase; Provisional


Pssm-ID: 236795  Cd Length: 390  Bit Score: 42.39  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178 1461 SQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKA----KTHYDAKKQQNQELQDQLRDLEQ 1519
Cdd:PRK10920   58 GKQQAQNQTATNDALANQLTALQKAQESQKQELEGIlkqqAKALDQANRQQAALAKQLDELQQ 120
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
891-1220 3.89e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  891 RLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTL 970
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEEL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  971 EHLKTQLVKKEKEQHPAgstggeeasapEAQLETVRKteapdpEVEALRAEVSKLEQQCQQQKQQVEGLTHSLESERASR 1050
Cdd:COG4372    83 EELNEQLQAAQAELAQA-----------QEELESLQE------EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1051 AEQDKALETLQGQLEEKTQELghsQAASASAQRELTALHAKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSIL 1130
Cdd:COG4372   146 AEREEELKELEEQLESLQEEL---AALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLE 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1131 NRQVLEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARAAERSSALREEVQSLREEVEKQRVISENLRQELTS 1210
Cdd:COG4372   223 AKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLL 302

                         330
                  ....*....|
gi 344240178 1211 QAERAEELGQ 1220
Cdd:COG4372   303 NLAALSLIGA 312
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 321-535 4.02e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.97  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  321 TQLQARIETLDCERSQQEaqllaerghFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTT 400
Cdd:cd22656    94 AEILELIDDLADATDDEE---------LEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  401 LQQQQDQELASLKEQAKKE-QAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEA 479
Cdd:cd22656   165 LKDLLTDEGGAIARKEIKDlQKELEKLNEEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGPA 244

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178  480 REAslrerdaarqqLETLEK---EKAAKLESLQQQLEaaNEARDSVQTSVTQVQQEKAE 535
Cdd:cd22656   245 IPA-----------LEKLQGawqAIATDLDSLKDLLE--DDISKIPAAILAKLELEKAI 290
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 335-722 4.05e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.69  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  335 SQQEAQLLAERGHFEEEKQQLASLIADLQSSIsnlsqakEELEQASQAQGAQLTAQVASLTALNTTLqqqqdqELASLKE 414
Cdd:NF033838  117 SKTKKELDAAFEQFKKDTLEPGKKVAEATKKV-------EEAEKKAKDQKEEDRRNYPTNTYKTLEL------EIAESDV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  415 QAKKEQAQMVQSlQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDhaqqlaivaEAREASLRERDAARQQL 494
Cdd:NF033838  184 EVKKAELELVKE-EAKEPRDEEKIKQAKAKVESKKAEATRLEKIKTDREKAEEE---------AKRRADAKLKEAVEKNV 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  495 ETLEKEKA---AKLESLQQQlEAANEARDSVQTSVTQVQQEK-AELSQKieelhacieaahQEQRQAQAHVTELEAQLKA 570
Cdd:NF033838  254 ATSEQDKPkrrAKRGVLGEP-ATPDKKENDAKSSDSSVGEETlPSPSLK------------PEKKVAEAEKKVEEAKKKA 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  571 EQQKVAERE------------KVMQEKAQLQEQLLAL--EEtlqiTKGSLEEEKHRTADALAEQQRC-VTKMEAESRSLM 635
Cdd:NF033838  321 KDQKEEDRRnyptntyktlelEIAESDVKVKEAELELvkEE----AKEPRNEEKIKQAKAKVESKKAeATRLEKIKTDRK 396

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  636 EQREQ-EQKALEQEKAGRKGLEArlQQLEEARQAETEALRrelAEATASQHRAESESEQLIREVeswqkrfEARQQEEaR 714
Cdd:NF033838  397 KAEEEaKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPK---PEKPAEQPKAEKPADQQAEED-------YARRSEE-E 463


                  ....*...
gi 344240178  715 YSAMIQEQ 722
Cdd:NF033838  464 YNRLTQQQ 471
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 285-621 4.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 42.79  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  285 ASQQCESPAQEKGEVLGDALQLEtLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQS 364
Cdd:PRK14949  384 ALAAAVQAPHANEPQFVNAAPAE-KKTALTEQTTAQQQVQAANAEAVAEADASAEPADTVEQALDDESELLAALNAEQAV 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  365 SISN-LSQAKEELEQASQAQGAQ--LTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQ---EQEQAAQGL- 437
Cdd:PRK14949  463 ILSQaQSQGFEASSSLDADNSAVpeQIDSTAEQSVVNPSVTDTQVDDTSASNNSAADNTVDDNYSAEdtlESNGLDEGDy 542

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  438 -----------------------RQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLAIVAEARE----ASLRERDAA 490
Cdd:PRK14949  543 aqdsapldayqddyvafssesynALSDDEQHSANVQSAQSAAEAQPSSQSLSPISAVTTAAASLADDdildAVLAARDSL 622

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  491 RQQLETLE-KEKAAKLESLQQQL-------EAANEARDSVQTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQ---- 558
Cdd:PRK14949  623 LSDLDALSpKEGDGKKSSADRKPktppsraPPASLSKPASSPDASQTSASFDLDPDFELATHQSVPEAALASGSAPappp 702

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  559 ------------AHVTELEAQLK---AEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEEEKHRTADALAEQQ 621
Cdd:PRK14949  703 vpdpydrppweeAPEVASANDGPnnaAEGNLSESVEDASNSELQAVEQQATHQPQVQAEAQSPASTTALTQTSSEVQD 780
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 497-1228 4.39e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.89  E-value: 4.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   497 LEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQqekAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVA 576
Cdd:pfam10174   47 LRKEEAARISVLKEQYRVTQEENQHLQLTIQALQ---DELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQS 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   577 EREKVMQEKAQLQEQLLALEetlqitkgsleeekhrtadalaeqqrcvTKMEAESRSLMEQREQEQKALEQEKAgrKGLE 656
Cdd:pfam10174  124 EHERQAKELFLLRKTLEEME----------------------------LRIETQKQTLGARDESIKKLLEMLQS--KGLP 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   657 ARLQQleearqaETEALRRELAEATASQHRAESESEQLIREV----ESWQKRFEArQQEEARYSAM--IQEQLAALKGDH 730
Cdd:pfam10174  174 KKSGE-------EDWERTRRIAEAEMQLGHLEVLLDQKEKENihlrEELHRRNQL-QPDPAKTKALqtVIEMKDTKISSL 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   731 EKAGQEAQEEAVEVHGEGQIG--EQQSPLAQLH----------TTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKV 798
Cdd:pfam10174  246 ERNIRDLEDEVQMLKTNGLLHteDREEEIKQMEvykshskfmkNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQH 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   799 AACLKTlVLKAGEQQ------EMTSLEL-LKEPPGAGNKESNWLEEqrggpFSSPQAALKAMEQEAEQMGSELERLRVAL 871
Cdd:pfam10174  326 IEVLKE-SLTAKEQRaailqtEVDALRLrLEEKESFLNKKTKQLQD-----LTEEKSTLAGEIRDLKDMLDVKERKINVL 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   872 MKSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEvrlqNTLNEQRVEFAALQEaldhaltEKEGKDQElak 951
Cdd:pfam10174  400 QKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLE----EALSEKERIIERLKE-------QREREDRE--- 465

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   952 lRGQEAAQ-RTELKELQQTLEHLKTQLVKKEKEQHPAGSTGGEEASAPeaqLETVRKTEAPDPEVEALRAEVSKLEQQCQ 1030
Cdd:pfam10174  466 -RLEELESlKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSG---LKKDSKLKSLEIAVEQKKEECSKLENQLK 541

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1031 QqkqqveglTHSLESERASRAEQDKALETLQGQLEEKTQELGHSQAasaSAQRELTAL-HAKAQDHSKAE--EEWKAQVA 1107
Cdd:pfam10174  542 K--------AHNAEEAVRTNPEINDRIRLLEQEVARYKEESGKAQA---EVERLLGILrEVENEKNDKDKkiAELESLTL 610

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1108 RGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKElkrlVVAESEKSQKLEERLRLLQvetasssaRAAERSSALREEV 1187
Cdd:pfam10174  611 RQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRRED----NLADNSQQLQLEELMGALE--------KTRQELDATKARL 678

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|...
gi 344240178  1188 QSLREEVEKQRVISENLRQELTSQAERAEELGQE--LKAWQEK 1228
Cdd:pfam10174  679 SSTQQSLAEKDGHLTNLRAERRKQLEEILEMKQEalLAAISEK 721
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 1149-1534 4.43e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 42.87  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1149 VAESEKSQKLEerLRLLQVETASSSARAAERSSALREEVQSLREEvEKQRVISENLRQELTSQAERAEELGQELKAWQEK 1228
Cdd:PRK10246  189 VFEQHKSARTE--LEKLQAQASGVALLTPEQVQSLTASLQVLTDE-EKQLLTAQQQQQQSLNWLTRLDELQQEASRRQQA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1229 FFQKEQAL--SALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHrEEIEQSKQAAGGLRAELMRAQrelgelgplr 1306
Cdd:PRK10246  266 LQQALAAEekAQPQLAALSLAQPARQLRPHWERIQEQSAALAHTRQQI-EEVNTRLQSTMALRARIRHHA---------- 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1307 qkvaeqERAAQQLRAEKASYAEQLSmlkkAHgllaeenrglgERANLGRQflevELDQAREKYVQElaavrTDAETHLAE 1386
Cdd:PRK10246  335 ------AKQSAELQAQQQSLNTWLA----EH-----------DRFRQWNN----ELAGWRAQFSQQ-----TSDREQLRQ 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1387 MRQEAQSTTRELEVMTAkyegakvkvleerqrfqeerQKLTAQVEELSKKLTEYDQaSKVQQQKLKAFQAQGGESQQEVQ 1466
Cdd:PRK10246  385 WQQQLTHAEQKLNALPA--------------------ITLTLTADEVAAALAQHAE-QRPLRQRLVALHGQIVPQQKRLA 443

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178 1467 RLQAQLNELQTQLSQKEQAAEHYKLQMekakthydakKQQNQELQDqLRDLEQLQKENKELRAEAERL 1534
Cdd:PRK10246  444 QLQVAIQNVTQEQTQRNAALNEMRQRY----------KEKTQQLAD-VKTICEQEARIKDLEAQRAQL 500
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 238-664 4.43e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 42.59  E-value: 4.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   238 EHNKASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKL--------------SQLEERASQQCESPAQEKGEVLGdA 303
Cdd:pfam15964  200 SHNLAERLKSATTGEDEKWRLELEKLKLLYEAKTEVLESQVkslrkdlaesqktcEDLKERLKHKESLVAASTSSRVG-G 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   304 LQLETLKQEAAKLAAHNTQLQARIETLDCERSQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEE----LEQA 379
Cdd:pfam15964  279 LCLKCAQHEAVLAQTHTNVHMQTIERLTKERDDLMSALVSVRSSLAEAQQRESSAYEQVKQAVQMTEEANFEktkaLIQC 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   380 SQAQgAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAA 459
Cdd:pfam15964  359 EQLK-SELERQKERLEKELASQQEKRAQEKEALRKEMKKEREELGATMLALSQNVAQLEAQVEKVTREKNSLVSQLEEAQ 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   460 KDQEAARQDHAQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELSQK 539
Cdd:pfam15964  438 KQLASQEMDVTKVCGEMRYQLNQTKMKKDEAEKEHREYRTKTGRQLEIKDQEIEKLGLELSESKQRLEQAQQDAARAREE 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   540 IEELHACIeaahqEQRQAQAHVTELEAQlkAEQQKVAEREKVMQEKAQLQEQllALEETLQITKGSLEEEKHRTADALAE 619
Cdd:pfam15964  518 CLKLTELL-----GESEHQLHLTRLEKE--SIQQSFSNEAKAQALQAQQREQ--ELTQKMQQMEAQHDKTVNEQYSLLTS 588

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 344240178   620 QQRCVTKMEAE--------------SRSLMEQREQEQKALeQEKAGRkgLEARLQQLEE 664
Cdd:pfam15964  589 QNTFIAKLKEEcctlakkleeitqkSRSEVEQLSQEKEYL-QDRLEK--LQKRNEELEE 644
PRK11637 PRK11637
AmiB activator; Provisional
 1301-1550 4.44e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 42.37  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1301 ELGPLRQKVAEQERAAQQLRAEKASYAEQLsmlKKAHGLLAEENRGLGE-RANLGRqfLEVELD---------QAREKYV 1370
Cdd:PRK11637   48 QLKSIQQDIAAKEKSVRQQQQQRASLLAQL---KKQEEAISQASRKLREtQNTLNQ--LNKQIDelnasiaklEQQQAAQ 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1371 QELAAVRTDAETHLAEMR--------QEAQSTTRELEVMTAKYEgAKVKVLEErqrFQEERQKLTAQVEELSKKLTEydq 1442
Cdd:PRK11637  123 ERLLAAQLDAAFRQGEHTglqlilsgEESQRGERILAYFGYLNQ-ARQETIAE---LKQTREELAAQKAELEEKQSQ--- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1443 askvQQQKLkafqaqgGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMekakthydAKKQQNQElqdQLRDleQLQK 1522
Cdd:PRK11637  196 ----QKTLL-------YEQQAQQQKLEQARNERKKTLTGLESSLQKDQQQL--------SELRANES---RLRD--SIAR 251

                         250       260
                  ....*....|....*....|....*...
gi 344240178 1523 ENKELRAEAERLGRELQQAGLKTKEAEQ 1550
Cdd:PRK11637  252 AEREAKARAEREAREAARVRDKQKQAKR 279
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1395-1540 4.44e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.79  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1395 TRELEVMTAKYE---GAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQGGESQQEVQRLQAQ 1471
Cdd:cd16269   148 LEDREKLVEKYRqvpRKGVKAEEVLQEFLQSKEAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLEEQQRELEQK 227

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1472 LNElqtqlsQKEQAAEHYKLQMEK-AKTHYDAKKQQNQELQDQLRDLEQLQKEnkELRAEAERLGRELQQ 1540
Cdd:cd16269   228 LED------QERSYEEHLRQLKEKmEEERENLLKEQERALESKLKEQEALLEE--GFKEQAELLQEEIRS 289
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1392-1576 4.56e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 4.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1392 QSTTRELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAFQAQggesQQEVQRLQAQ 1471
Cdd:pfam07888   37 EECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEK----YKELSASSEE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1472 LNELQTQLSQKEQAAEHYKLQMEKaktHYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLGRELQqagLKTKEAEQA 1551
Cdd:pfam07888  113 LSEEKDALLAQRAAHEARIRELEE---DIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQ---AKLQQTEEE 186

                          170       180
                   ....*....|....*....|....*
gi 344240178  1552 CRHLSAQVRSLEAQVAHADQQLRDL 1576
Cdd:pfam07888  187 LRSLSKEFQELRNSLAQRDTQVLQL 211
46 PHA02562
endonuclease subunit; Provisional
 1356-1587 4.56e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 42.69  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1356 QFLEVELDQARE------KYVQELAAVRTDAETHLAEMRQEAQSTTRELEvmtAKYEGAKVKVLEerqrFQEERQKLTAQ 1429
Cdd:PHA02562  184 QTLDMKIDHIQQqiktynKNIEEQRKKNGENIARKQNKYDELVEEAKTIK---AEIEELTDELLN----LVMDIEDPSAA 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1430 VEELSKKLTeyDQASKVQQ-QKLKAFQAQGGES---QQEVQRLQAQLNELQTQLSQkeqaaehYKLQMEKAKTHYDakkq 1505
Cdd:PHA02562  257 LNKLNTAAA--KIKSKIEQfQKVIKMYEKGGVCptcTQQISEGPDRITKIKDKLKE-------LQHSLEKLDTAID---- 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1506 qnqELQDQLRDLEQLQKENKELRAEAERLGRELQQAGLKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGK------- 1578
Cdd:PHA02562  324 ---ELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKtkselvk 400

                         250
                  ....*....|...
gi 344240178 1579 ----FQVATDALK 1587
Cdd:PHA02562  401 ekyhRGIVTDLLK 413
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 1350-1491 4.73e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 42.03  E-value: 4.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1350 RANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRELEVMTAKYEGAKVKV---LEERQRFQEERQKL 1426
Cdd:pfam00529   71 QAQVARLQAELDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLApigGISRESLVTAGALV 150

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 344240178  1427 TAQVEELSKKLTEYDQASKVQQQKLKAFQAqggESQQEVQRLQAQLNELQTQLSQKEQAAEHYKL 1491
Cdd:pfam00529  151 AQAQANLLATVAQLDQIYVQITQSAAENQA---EVRSELSGAQLQIAEAEAELKLAKLDLERTEI 212
PRK12704 PRK12704
phosphodiesterase; Provisional
 605-741 4.81e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  605 SLEEEKHRTADALAEQQRCVTKMEAESRS---LMEQREQEQKA---LEQEKAGRKG----LEARLQQLEEARQAETEALR 674
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKKEAEAIKkeaLLEAKEEIHKLrneFEKELRERRNelqkLEKRLLQKEENLDRKLELLE 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 344240178  675 RElaeatasqhraESESEQLIREVESWQKRFEARQQEearYSAMIQEQLAALkgdhEKAGQEAQEEA 741
Cdd:PRK12704  107 KR-----------EEELEKKEKELEQKQQELEKKEEE---LEELIEEQLQEL----ERISGLTAEEA 155
PRK12704 PRK12704
phosphodiesterase; Provisional
 404-542 4.85e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 4.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  404 QQDQELASLKEQAKKEQAQMVQSLQEQEQAaqgLRQQVEQL---SSSLKLKEQQLEEAAKDqeaarqdhaqqlaivAEAR 480
Cdd:PRK12704   61 EAKEEIHKLRNEFEKELRERRNELQKLEKR---LLQKEENLdrkLELLEKREEELEKKEKE---------------LEQK 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178  481 EASLRERdaaRQQLETLEKEKAAKLESLQQQleAANEARDSVQTSV-TQVQQEKAELSQKIEE 542
Cdd:PRK12704  123 QQELEKK---EEELEELIEEQLQELERISGL--TAEEAKEILLEKVeEEARHEAAVLIKEIEE 180
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
169-449 4.99e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  169 LEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLS--EENGDLSFKVREFASHLQQLQGAFNDLTEEHN------ 240
Cdd:COG4913   612 LAALEAELAELEEELAEAEERLEALEAELDALQERREALQrlAEYSWDEIDVASAEREIAELEAELERLDASSDdlaale 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  241 KASQEWAEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASqqcespAQEKGEVLGDALQLETLKQEAAKLAAHN 320
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLE------AAEDLARLELRALLEERFAAALGDAVER 765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  321 T---QLQARIETLDCERSQQEAQLlaeRGHFEEEKQQLASLIADLQSSISNLSQAKEELEQasqaqgaqltaqvasLTAL 397
Cdd:COG4913   766 ElreNLEERIDALRARLNRAEEEL---ERAMRAFNREWPAETADLDADLESLPEYLALLDR---------------LEED 827

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 344240178  398 NttLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAqglRQQVEQLSSSLK 449
Cdd:COG4913   828 G--LPEYEERFKELLNENSIEFVADLLSKLRRAIREI---KERIDPLNDSLK 874
46 PHA02562
endonuclease subunit; Provisional
 392-612 5.05e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 42.31  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  392 ASLTALNTTLQQQQDQELASLKEQAK--KEQAQMVQSLQEQEQAAQGLRQQVEQlssslKLKEQQLEEA--AKDQEAARQ 467
Cdd:PHA02562  166 SEMDKLNKDKIRELNQQIQTLDMKIDhiQQQIKTYNKNIEEQRKKNGENIARKQ-----NKYDELVEEAktIKAEIEELT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  468 DHAQQLAIVAEAREASLrerdaarQQLETLEKEKAAKLESLQ----------------QQLEAANEARDSVQTSVTQVQQ 531
Cdd:PHA02562  241 DELLNLVMDIEDPSAAL-------NKLNTAAAKIKSKIEQFQkvikmyekggvcptctQQISEGPDRITKIKDKLKELQH 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  532 EKAELSQKIEELhaciEAAHQEQRQAQAHVTELEAQLKAE-QQKVAEREKVMQEKAQLQE-------------QLLALEE 597
Cdd:PHA02562  314 SLEKLDTAIDEL----EEIMDEFNEQSKKLLELKNKISTNkQSLITLVDKAKKVKAAIEElqaefvdnaeelaKLQDELD 389

                         250
                  ....*....|....*
gi 344240178  598 TLQITKGSLEEEKHR 612
Cdd:PHA02562  390 KIVKTKSELVKEKYH 404
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 369-694 5.50e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.95  E-value: 5.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   369 LSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQ-MVQSLQEQEQAAQGLRQQveqlsSS 447
Cdd:pfam15558   14 LARHKEEQRMRELQQQAALAWEELRRRDQKRQETLERERRLLLQQSQEQWQAEKeQRKARLGREERRRADRRE-----KQ 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   448 LKLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASlrerdaARQQLETLEKEKAAKLESLQQQL-EAANEARDSVQTSV 526
Cdd:pfam15558   89 VIEKESRWREQAEDQENQRQEKLERARQEAEQRKQC------QEQRLKEKEEELQALREQNSLQLqERLEEACHKRQLKE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   527 TQVQQEKAELSQKIEELH-------ACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAE----REKVMQEKAQLQEQLLAL 595
Cdd:pfam15558  163 REEQKKVQENNLSELLNHqarkvlvDCQAKAEELLRRLSLEQSLQRSQENYEQLVEERhrelREKAQKEEEQFQRAKWRA 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   596 EETLQITKGSLE------EEKHRTADALAEQQ-RCVTKMEAESRSLME--QREQEQKALEQEKAGRKGLEA-------RL 659
Cdd:pfam15558  243 EEKEEERQEHKEalaelaDRKIQQARQVAHKTvQDKAQRARELNLEREknHHILKLKVEKEEKCHREGIKEaikkkeqRS 322

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 344240178   660 QQLEEARQAETEALRRelaEATASQHRAESESEQL 694
Cdd:pfam15558  323 EQISREKEATLEEARK---TARASFHMREKVREET 354
CCDC154 pfam15450
Coiled-coil domain-containing protein 154; CCDC154 is an osteopetrosis-related protein that ...
 353-736 5.50e-03

Coiled-coil domain-containing protein 154; CCDC154 is an osteopetrosis-related protein that suppresses cell proliferation by inducing G2/M arrest.


Pssm-ID: 464723 [Multi-domain]  Cd Length: 526  Bit Score: 42.13  E-value: 5.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   353 QQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLtalnttlqQQQDQELASLKeqakkeqaqmvqslQEQEQ 432
Cdd:pfam15450   16 KQLEQWVADLQAEVVSLRGHKERCEHATLSLLRELLQVRAHV--------QLQDSELKQLR--------------QEVQQ 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   433 AAQGLRQQVEQLSSSLKLKEQQLEEaakdqeaarqdhaQQLAIVAEAREASLRERDAARQQLETLEKEKAAKLESLQQQL 512
Cdd:pfam15450   74 AARAPEKEALEFPGPQNQNQMQALD-------------KRLVEVREALTQIRRKQALQDSERKGAEQEANLRLTKLTGKL 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   513 EAANEARdsvQTSVTQVQQEKAELSQKIEelhacieaahQEQRQAQAHVTELEAQLKAeqqKVAEREKVMQekAQLQEQL 592
Cdd:pfam15450  141 KQEEQGR---EAACSALQKSQEEASQKVD----------HEVARMQAQVTKLGEEMSL---RFLKREAKLC--SFLQKSF 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   593 LALEETLQITKGS-LEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKagrKGLEARLQQLEE-ARQAET 670
Cdd:pfam15450  203 LALEKRMKASESTrLKAESSLREELEGRWQKLQELTEERLRALQGQREQEEGHLLEQC---RGLDAAVVQLTKfVRQNQV 279

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178   671 EALRRELAEATA-------SQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQE 736
Cdd:pfam15450  280 SLNRVLLAEQKArdakgqlEESQAGELASYVQENLEAVQLAGELAQQETQGALELLQEKSQVLEGSVAELVRQ 352
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 639-1059 5.51e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 41.98  E-value: 5.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   639 EQEQKALEQEKAGRKGLEARLQQLeearQAETEALRRELAEATASQHRAESEseqlireveswqkrfearqqeearysam 718
Cdd:pfam19220   37 EAILRELPQAKSRLLELEALLAQE----RAAYGKLRRELAGLTRRLSAAEGE---------------------------- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   719 iQEQLAALKGDHEKAGQEAQEEAVEvhgegqigeQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKV 798
Cdd:pfam19220   85 -LEELVARLAKLEAALREAEAAKEE---------LRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKA 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   799 AACLKTLVLKAGEQQEMTSLEllkeppgagNKESNWLEEQRGGPFSSPQAALKAMEQEAEQMGSELERLRVALMKSQGQQ 878
Cdd:pfam19220  155 LQRAEGELATARERLALLEQE---------NRRLQALSEEQAAELAELTRRLAELETQLDATRARLRALEGQLAAEQAER 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   879 QEERGQQEREVARLTRERSQAQADL--AQEKAAKAE-LEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELAKLRGQ 955
Cdd:pfam19220  226 ERAEAQLEEAVEAHRAERASLRMKLeaLTARAAATEqLLAEARNQLRDRDEAIRAAERRLKEASIERDTLERRLAGLEAD 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   956 EAAQRTELKELQQ---TLEHLKTQLVKKEKEQHPAGSTGGEEASAPEAQLETVRKteapDPEVEALRAEvskleqqcqqq 1032
Cdd:pfam19220  306 LERRTQQFQEMQRaraELEERAEMLTKALAAKDAALERAEERIASLSDRIAELTK----RFEVERAALE----------- 370

                          410       420
                   ....*....|....*....|....*..
gi 344240178  1033 kQQVEGLTHSLESERASRAEQDKALET 1059
Cdd:pfam19220  371 -QANRRLKEELQRERAERALAQGALEI 396
PRK10927 PRK10927
cell division protein FtsN;
350-525 5.51e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.59  E-value: 5.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  350 EEKQQLASLIADLQSSISNLSQAK-EELEQASQAQGAQLTAQVASLTalnttlQQQQDQELASLKEQAKKEQAQMVQSLQ 428
Cdd:PRK10927  117 EQRQLLEQMQADMRQQPTQLVEVPwNEQTPEQRQQTLQRQRQAQQLA------EQQRLAQQSRTTEQSWQQQTRTSQAAP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  429 EQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAqqlaivAEAREASLRERDAARQQLETLEKEKAAKLESL 508
Cdd:PRK10927  191 VQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPVTRA------ADAPKPTAEKKDERRWMVQCGSFRGAEQAETV 264

                         170
                  ....*....|....*..
gi 344240178  509 QQQLeaANEARDSVQTS 525
Cdd:PRK10927  265 RAQL--AFEGFDSKITT 279
Apolipoprotein pfam01442
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a ...
 1358-1488 5.59e-03

Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.


Pssm-ID: 460211 [Multi-domain]  Cd Length: 175  Bit Score: 40.32  E-value: 5.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1358 LEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTTRE----LEVMTAKYEGAKVKVLEE-----RQRFQEERQKLTA 1428
Cdd:pfam01442   31 LEKETEALRERLQKDLEEVRAKLEPYLEELQAKLGQNVEElrqrLEPYTEELRKRLNADAEElqeklAPYGEELRERLEQ 110

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178  1429 QVEELSKKLTEYDQASKVQ-QQKLKAFQAQGGESQQEVQ-RLQAQLNELQTQLSQKEQAAEH 1488
Cdd:pfam01442  111 NVDALRARLAPYAEELRQKlAERLEELKESLAPYAEEVQaQLSQRLQELREKLEPQAEDLRE 172
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 87-328 6.03e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   87 FLSGSPSSPMGDILQTPQFQMRRLKKQLADERNNRDELELELSESLKLLTEKDAQIAMMQQRIDHLallnekqaassqeS 166
Cdd:COG4942     9 LLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL-------------E 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  167 RELEELRGKNESLTVRLHETLKQCQNLKTEKNQMDRKISQLSEENGDLSFKVREFASHLQQLQGAFNDLTEEHNKASQEW 246
Cdd:COG4942    76 QELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEEL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  247 AEKQTHLEKELSTALQDKKYLEEKNEILQGKLSQLEERASQQCESPAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQAR 326
Cdd:COG4942   156 RADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235


                  ..
gi 344240178  327 IE 328
Cdd:COG4942   236 AA 237
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1443-1596 6.18e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1443 ASKVQQQKLKAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLE---- 1518
Cdd:COG4942    14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEkeia 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1519 QLQKENKELRAEAERLGRELQQAG--------LKTKEAEQACRHLSAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1590
Cdd:COG4942    94 ELRAELEAQKEELAELLRALYRLGrqpplallLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173


                  ....*.
gi 344240178 1591 PQKPQL 1596
Cdd:COG4942   174 AELEAL 179
Rootletin pfam15035
Ciliary rootlet component, centrosome cohesion;
414-544 6.32e-03

Ciliary rootlet component, centrosome cohesion;


Pssm-ID: 464459 [Multi-domain]  Cd Length: 190  Bit Score: 40.41  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   414 EQAKKEQAQMVQSLQ----EQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKDQEAARqdhaqqlaiVAEAREASLRErda 489
Cdd:pfam15035    8 QEAQQRQAQLVQKLQakvlQYKKRCSELEQQLLEKTSELEKTELLLRKLTLEPRLQR---------LEREHSADLEE--- 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178   490 ARQQLETlEKEKAAKL----ESLQQQLEAANEA----RDSVQTSVTQVQQEKAELSQKIEELH 544
Cdd:pfam15035   76 ALIRLEE-ERQRSESLsqvnSLLREQLEQASRAnealREDLQKLTNDWERAREELEQKESEWR 137
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
947-1176 6.61e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.93  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  947 QELAKLRGQEAAQRTELkeLQQTLEHLKTQLVKKE------KEQHPAGSTGgEEASAPEAQLETVRKteapdpEVEALRA 1020
Cdd:COG3206   163 EQNLELRREEARKALEF--LEEQLPELRKELEEAEaaleefRQKNGLVDLS-EEAKLLLQQLSELES------QLAEARA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1021 EVSKLEQQCQQQKQQVEGLTHSLESERASRAEQD--KALETLQGQLEEKTQELG--HSQAASASAQRElTALHAKAQDHS 1096
Cdd:COG3206   234 ELAEAEARLAALRAQLGSGPDALPELLQSPVIQQlrAQLAELEAELAELSARYTpnHPDVIALRAQIA-ALRAQLQQEAQ 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1097 KAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNrqvlEKEGESKELKRLVVAESEKSQKLEERLRLLQVETASSSARA 1176
Cdd:COG3206   313 RILASLEAELEALQAREASLQAQLAQLEARLAELP----ELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNV 388
Rab5-bind pfam09311
Rabaptin-like protein; Members of this family are predominantly found in Rabaptin and allow ...
 335-600 6.64e-03

Rabaptin-like protein; Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes.


Pssm-ID: 462752 [Multi-domain]  Cd Length: 307  Bit Score: 41.49  E-value: 6.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   335 SQQEAQLLAERGHFEEEKQQ---LASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQDQELAS 411
Cdd:pfam09311    5 SNYEKQLQAIQEQEAETRDQvkkLQEMLRQANDQLEKTMKDKKELEDKMNQLSEETSNQVSTLAKRNQKSETLLDELQQA 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   412 LKEQAKKEQAQMVQSLQEQEQAAQG---LRQQVEQLSSSLKLkEQQLEEAAKDQEAARQDHAQQLaiVAEAREASLRERD 488
Cdd:pfam09311   85 FSQAKRNFQDQLAVLMDSREQVSDElvrLQKDNESLQGKHSL-HVSLQQAEKFDMPDTVQELQEL--VLKYREELIEVRT 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   489 AARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQE-------KAELSQKI---EELHACIEAAHQEQRQAQ 558
Cdd:pfam09311  162 AADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQAEIENCKEEiasisslKVELERIKaekEQLENGLTEKIRQLEDLQ 241

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 344240178   559 AHVTELEAQLKAEQQKVAEREKVMQE---KAQLQEQLLALEETLQ 600
Cdd:pfam09311  242 TTKGSLETQLKKETNEKAAVEQLVFEeknKAQRLQTELDVSEQVQ 286
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 339-501 6.79e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.54  E-value: 6.79e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    339 AQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQ----------ASQAQGAQLTAQVASLTALNTTLQQQQDQE 408
Cdd:smart00787  126 ARLEAKKMWYEWRMKLLEGLKEGLDENLEGLKEDYKLLMKelellnsikpKLRDRKDALEEELRQLKQLEDELEDCDPTE 205

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178    409 LASLKEQAKKEQAQMVQSLQEQEQaaqgLRQQVEQLssslklkEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERD 488
Cdd:smart00787  206 LDRAKEKLKKLLQEIMIKVKKLEE----LEEELQEL-------ESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIE 274

                           170
                    ....*....|...
gi 344240178    489 AARQQLETLEKEK 501
Cdd:smart00787  275 KLKEQLKLLQSLT 287
PRK01156 PRK01156
chromosome segregation protein; Provisional
 98-686 6.98e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.20  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   98 DILQTPQFQMRRLKKQLADERNNrdelelelseslklltekdaqiammqqridHLALLNEKQAASSQESRELEELrgkne 177
Cdd:PRK01156  190 EKLKSSNLELENIKKQIADDEKS------------------------------HSITLKEIERLSIEYNNAMDDY----- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  178 sltVRLHETLKQCQNLKTEKNQMDrkiSQLSEENGDLSFKVREFAShlqqlqgaFNDLTEEHNKASQEWAEKQthlEKEL 257
Cdd:PRK01156  235 ---NNLKSALNELSSLEDMKNRYE---SEIKTAESDLSMELEKNNY--------YKELEERHMKIINDPVYKN---RNYI 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  258 STALQDKKYLEEKNEILQG-------------KLSQLEERASQQCESpAQEKGEVLGDALQLETLKQEAAKLAAHNTQLQ 324
Cdd:PRK01156  298 NDYFKYKNDIENKKQILSNidaeinkyhaiikKLSVLQKDYNDYIKK-KSRYDDLNNQILELEGYEMDYNSYLKSIESLK 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  325 ARIETLDCERSQQEAQ--------------LLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQAQGAQLTAQ 390
Cdd:PRK01156  377 KKIEEYSKNIERMSAFiseilkiqeidpdaIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCP 456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  391 VASlTALNTT----LQQQQDQELASLKE-------QAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAA 459
Cdd:PRK01156  457 VCG-TTLGEEksnhIINHYNEKKSRLEEkireieiEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIK 535

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  460 KDQEAARQDHAQQLAIVAEAREASLRERDAARQQ-LETLEKEKAAKLESLQQQLEAANEARDSVQTSVTQVQQEKAELS- 537
Cdd:PRK01156  536 IKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSwLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKs 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  538 ------QKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREKVMQEKAQLQEQLLALEETLQITKGSLEeekh 611
Cdd:PRK01156  616 yidksiREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALD---- 691

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  612 rtaDALAEQQRCVTKMEAeSRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQAETEA-----LRRELAEATASQHR 686
Cdd:PRK01156  692 ---DAKANRARLESTIEI-LRTRINELSDRINDINETLESMKKIKKAIGDLKRLREAFDKSgvpamIRKSASQAMTSLTR 767
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 1384-1541 7.03e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.66  E-value: 7.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1384 LAEMRQEAQSTTRELEVMTAkyegakvkvleERQRFQEERQKLTAQVEELSKKLTEYDQaskvQQQKLKAFQAQGGESQQ 1463
Cdd:pfam13851   35 IAELKKKEERNEKLMSEIQQ-----------ENKRLTEPLQKAQEEVEELRKQLENYEK----DKQSLKNLKARLKVLEK 99

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  1464 EVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYdakkQQNQELQDQLrdleqLQKENKELRAEAERLGRELQQA 1541
Cdd:pfam13851  100 ELKDLKWEHEVLEQRFEKVERERDELYDKFEAAIQDV----QQKTGLKNLL-----LEKKLQALGETLEKKEAQLNEV 168
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
889-1026 7.03e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 41.57  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  889 VARLTRERSQAQADLAQEKAAKAELEVRLQNTLNEQRVEFAALQEALDHALTEKEGKDQELA---KLRGQEAAQRTELKE 965
Cdd:COG1566    73 LARLDPTDLQAALAQAEAQLAAAEAQLARLEAELGAEAEIAAAEAQLAAAQAQLDLAQRELEryqALYKKGAVSQQELDE 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178  966 LQQTLEHLKTQLVKKEKEQhpagstggEEASAPEAQLETVRKTEApdpEVEALRAEVSKLE 1026
Cdd:COG1566   153 ARAALDAAQAQLEAAQAQL--------AQAQAGLREEEELAAAQA---QVAQAEAALAQAE 202
46 PHA02562
endonuclease subunit; Provisional
 535-745 7.10e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 7.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  535 ELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQK--------VAEREKVMQEKAQLQEQLLALEETLQITKGSL 606
Cdd:PHA02562  178 ELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARkqnkydelVEEAKTIKAEIEELTDELLNLVMDIEDPSAAL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  607 EEEKHRTADALAEQQRC--VTKMEAESR---SLMEQREQEQKALEQEKAGRKGLEARLQQLEEARQaETEALRRELAEAT 681
Cdd:PHA02562  258 NKLNTAAAKIKSKIEQFqkVIKMYEKGGvcpTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAID-ELEEIMDEFNEQS 336

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  682 ASQH----RAESESEQLIREVESwQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQEEAVEVH 745
Cdd:PHA02562  337 KKLLelknKISTNKQSLITLVDK-AKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKY 403
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 279-528 7.10e-03

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 41.24  E-value: 7.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   279 SQLEERASQqcESPAQEKGEVLGDalQLETLKQEAAKLAAHNTQLQARIETL--DCERSQQEAQLLAErghfeeekqQLA 356
Cdd:pfam06008   26 KQLQEYLSP--ENAHKIQIEILEK--ELSSLAQETEELQKKATQTLAKAQQVnaESERTLGHAKELAE---------AIK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   357 SLIADLQSSISNLSQAKEELEQASqaqgaqltaqvasltalNTTLQQQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQG 436
Cdd:pfam06008   93 NLIDNIKEINEKVATLGENDFALP-----------------SSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQD 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   437 LRQQVEQLSSSLKLKEQQLEEAAKDQEAARQDHAQQLaivaearEASLRERDAARQQLETLEKEKAAKLESLQQQLEAAN 516
Cdd:pfam06008  156 LLSRIQTWFQSPQEENKALANALRDSLAEYEAKLSDL-------RELLREAAAKTRDANRLNLANQANLREFQRKKEEVS 228

                          250
                   ....*....|..
gi 344240178   517 EARDSVQTSVTQ 528
Cdd:pfam06008  229 EQKNQLEETLKT 240
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 1396-1540 7.15e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 41.12  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1396 RELEVMTAKYE---GAKVKVLEERQRFQEERQKLTAQVEELSKKLTEYDQASKVQQQKLKAfqaqggeSQQEVQRLQAQL 1472
Cdd:pfam02841  155 EERDKLEAKYNqvpRKGVKAEEVLQEFLQSKEAVEEAILQTDQALTAKEKAIEAERAKAEA-------AEAEQELLREKQ 227

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1473 NELQTQLSQKEQAAEHYKLQM-EKAKThydAKKQQNQELQDQLRDLEQLQKE--NKELRAEAERLGRELQQ 1540
Cdd:pfam02841  228 KEEEQMMEAQERSYQEHVKQLiEKMEA---EREQLLAEQERMLEHKLQEQEEllKEGFKTEAESLQKEIQD 295
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 583-824 7.23e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 41.86  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  583 QEKAQLQEQllaleetlqitkgslEEEKHRtadalAEQQRcvtkmeaesrslmeQR-EQEQKALEQEKAGRkglEARLQQ 661
Cdd:PRK05035  433 QAKAEIRAI---------------EQEKKK-----AEEAK--------------ARfEARQARLEREKAAR---EARHKK 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  662 LEEARQAET-----EALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGD------- 729
Cdd:PRK05035  476 AAEARAAKDkdavaAALARVKAKKAAATQPIVIKAGARPDNSAVIAAREARKAQARARQAEKQAAAAADPKKAavaaaia 555

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  730 HEKAGQEAQEEAvevhGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMAstsKVAACLKTLVLKA 809
Cdd:PRK05035  556 RAKAKKAAQQAA----NAEAEEEVDPKKAAVAAAIARAKAKKAAQQAASAEPEEQVAEVDPKKA---AVAAAIARAKAKK 628

                         250
                  ....*....|....*
gi 344240178  810 GEQQEMTSLELLKEP 824
Cdd:PRK05035  629 AEQQANAEPEEPVDP 643
Apolipoprotein pfam01442
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a ...
 347-513 7.27e-03

Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.


Pssm-ID: 460211 [Multi-domain]  Cd Length: 175  Bit Score: 39.94  E-value: 7.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   347 HFEEEKQQLASLIADLQSsisNLSQAKEELEQASQAQGAQLTAQVASLTA-LNTTLQQQQD---QELASLKEQAKKEQAQ 422
Cdd:pfam01442   12 YAEELQEQLGPVAQELVD---RLEKETEALRERLQKDLEEVRAKLEPYLEeLQAKLGQNVEelrQRLEPYTEELRKRLNA 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   423 MVQSLQEQ-EQAAQGLRQQVEQLSSSLKlkeQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRERdaARQQLETLEKEK 501
Cdd:pfam01442   89 DAEELQEKlAPYGEELRERLEQNVDALR---ARLAPYAEELRQKLAERLEELKESLAPYAEEVQAQ--LSQRLQELREKL 163

                          170
                   ....*....|..
gi 344240178   502 AAKLESLQQQLE 513
Cdd:pfam01442  164 EPQAEDLREKLD 175
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 369-538 7.43e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 41.28  E-value: 7.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   369 LSQAKEELEQAsQAQGAQLTAQVASLTALNTTLQQQQDQELASLKEQakkeqaqmVQSLQEQEQAAQGLRQQVEQLSSSL 448
Cdd:pfam09787   49 LEELRQERDLL-REEIQKLRGQIQQLRTELQELEAQQQEEAESSREQ--------LQELEEQLATERSARREAEAELERL 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   449 KLKEQQLEEAAKDQEAARQDHAQQLAIVAEAREASLRER---DAARQQLETLEKEKAAKLESLQQQLEAANEARDSVQTS 525
Cdd:pfam09787  120 QEELRYLEEELRRSKATLQSRIKDREAEIEKLRNQLTSKsqsSSSQSELENRLHQLTETLIQKQTMLEALSTEKNSLVLQ 199

                          170
                   ....*....|...
gi 344240178   526 VTQVQQEKAELSQ 538
Cdd:pfam09787  200 LERMEQQIKELQG 212
PTZ00491 PTZ00491
major vault protein; Provisional
 510-684 7.52e-03

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 41.93  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  510 QQLEAANEA-RDSVQTSVtqvqQEKAELSQKIEELHACIEAAHQEQrqaqahvtelEAQLKAEQQKVAEREKVMQEKAQL 588
Cdd:PTZ00491  636 QSVEPVDERtRDSLQKSV----QLAIEITTKSQEAAARHQAELLEQ----------EARGRLERQKMHDKAKAEEQRTKL 701

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  589 QEqLLALEETLQITKGSLEEEKHRTADALAEQQRCV--TKMEAESRSLME--QREQEQKALEQEkagrkglearLQQleE 664
Cdd:PTZ00491  702 LE-LQAESAAVESSGQSRAEALAEAEARLIEAEAEVeqAELRAKALRIEAeaELEKLRKRQELE----------LEY--E 768

                         170       180
                  ....*....|....*....|.
gi 344240178  665 ARQAETE-ALRRELAEATASQ 684
Cdd:PTZ00491  769 QAQNELEiAKAKELADIEATK 789
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 847-1535 7.73e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 42.09  E-value: 7.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  847 QAALKAMEQEAEQMGSELERLRVALmkSQGQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAeLEVRLQNTLNEQRV 926
Cdd:PRK10246  263 QQALQQALAAEEKAQPQLAALSLAQ--PARQLRPHWERIQEQSAALAHTRQQIEEVNTRLQSTMA-LRARIRHHAAKQSA 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  927 EFAALQEALDHALTEKEGK---DQELAKLRGQEAAQ---RTELKELQQTLEHLKTQLvkkekeqhpagstggeeASAPEA 1000
Cdd:PRK10246  340 ELQAQQQSLNTWLAEHDRFrqwNNELAGWRAQFSQQtsdREQLRQWQQQLTHAEQKL-----------------NALPAI 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1001 QLetvrkTEAPDpEVEALRAEvskleqqcqqqkqqveglthsLESERASRaeqdKALETLQGQLEEKTQELGHSQAASAS 1080
Cdd:PRK10246  403 TL-----TLTAD-EVAAALAQ---------------------HAEQRPLR----QRLVALHGQIVPQQKRLAQLQVAIQN 451

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1081 AQRELT----ALHAKAQDHSKAEEEWKAQVARGQQEAErksslISSLEEEVSILNR------------------QVLEKe 1138
Cdd:PRK10246  452 VTQEQTqrnaALNEMRQRYKEKTQQLADVKTICEQEAR-----IKDLEAQRAQLQAgqpcplcgstshpaveayQALEP- 525

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1139 geSKELKRLVVAESEKSQKLEERLRLL-QVETASSS-ARAAERSSALREEVQSLREEvekqrvisenlRQELTSQAERAE 1216
Cdd:PRK10246  526 --GVNQSRLDALEKEVKKLGEEGAALRgQLDALTKQlQRDESEAQSLRQEEQALTQQ-----------WQAVCASLNITL 592

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1217 ELGQELKAWQEKFFQKEQALsalqlehtstqalvsELLPAKHLCQQLQAEQAAAEKRHREEIEQSKQAaggLRAELMRAQ 1296
Cdd:PRK10246  593 QPQDDIQPWLDAQEEHERQL---------------RLLSQRHELQGQIAAHNQQIIQYQQQIEQRQQQ---LLTALAGYA 654

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1297 RELGELGPLRQKVAEQERAA---QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANlgrqfleVELDQAREKYVQEL 1373
Cdd:PRK10246  655 LTLPQEDEEASWLATRQQEAqswQQRQNELTALQNRIQQLTPLLETLPQSDDLPHSEET-------VALDNWRQVHEQCL 727

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1374 AAvrtdaETHLAEMRQEAQSTTRELEVMTAKYEGA-KVKVLEERQRFqeerqkLTAQV-EELSKKLTEYDQASKVQQQKL 1451
Cdd:PRK10246  728 SL-----HSQLQTLQQQDVLEAQRLQKAQAQFDTAlQASVFDDQQAF------LAALLdEETLTQLEQLKQNLENQRQQA 796

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1452 KAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQDQLRDLEQLQKENKELRAEA 1531
Cdd:PRK10246  797 QTLVTQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALMQQIAQATQQV 876


                  ....
gi 344240178 1532 ERLG 1535
Cdd:PRK10246  877 EDWG 880
PRK12705 PRK12705
hypothetical protein; Provisional
 508-684 7.96e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 41.62  E-value: 7.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  508 LQQQLEAANEARDSVQTSVTQVQQEKAELSQKIEELhaCIEAAHQEQRQAQAHVTELEAQ----LKAEQQKVAEREKVmq 583
Cdd:PRK12705   25 LKKRQRLAKEAERILQEAQKEAEEKLEAALLEAKEL--LLRERNQQRQEARREREELQREeerlVQKEEQLDARAEKL-- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  584 ekAQLQEQLLALEETLQITKGSLEEEKHRTADALaeqQRCVTKMEAESRSLMEQReqEQKALEQEKAGRKGL---EARLQ 660
Cdd:PRK12705  101 --DNLENQLEEREKALSARELELEELEKQLDNEL---YRVAGLTPEQARKLLLKL--LDAELEEEKAQRVKKieeEADLE 173

                         170       180
                  ....*....|....*....|....
gi 344240178  661 QLEEARQAETEALRReLAEATASQ 684
Cdd:PRK12705  174 AERKAQNILAQAMQR-IASETASD 196
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 847-1238 8.04e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 41.65  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   847 QAALKAMEQEAEQMGSELERLRVALMKSQGQQQEErgqqerevarLTRERSQAQADLAQEKAAKaELEVRLQNTLNEQRV 926
Cdd:pfam05557    8 KARLSQLQNEKKQMELEHKRARIELEKKASALKRQ----------LDRESDRNQELQKRIRLLE-KREAEAEEALREQAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   927 EFAALQEALDHALTEKEGKDQELAKLRGQEAAQRTELKELQQTLE----HLKTQLVKKE--KEQHPAGSTGGEEASAPEA 1000
Cdd:pfam05557   77 LNRLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQraelELQSTNSELEelQERLDLLKAKASEAEQLRQ 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1001 QLETVRKTEA-PDPEVEALRAEVSKLEQQCQQQKQQVEGLTH--SLESERASRAEQDKALETLQGQ---LEEKTQELGH- 1073
Cdd:pfam05557  157 NLEKQQSSLAeAEQRIKELEFEIQSQEQDSEIVKNSKSELARipELEKELERLREHNKHLNENIENkllLKEEVEDLKRk 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1074 ------SQAASASAQRELTALHAK-------AQDHS---KAEEEWKAQVARGQQE----AERKSSLISS----------L 1123
Cdd:pfam05557  237 lereekYREEAATLELEKEKLEQElqswvklAQDTGlnlRSPEDLSRRIEQLQQReivlKEENSSLTSSarqlekarreL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  1124 EEEVSILNRQVLEKEGESKELKRLVvaeseksQKLEERLRLLQVE----------------TASSSARAAERSSALREEV 1187
Cdd:pfam05557  317 EQELAQYLKKIEDLNKKLKRHKALV-------RRLQRRVLLLTKErdgyrailesydkeltMSNYSPQLLERIEEAEDMT 389

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 344240178  1188 QSLREEVEKQRVISENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSA 1238
Cdd:pfam05557  390 QKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLADPSYSK 440
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 677-962 8.15e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  677 LAEATASQHRAESESEQLIREVESWQKRFEARQQEEARysamIQEQLAALkgdhekagqeaqeeavevhgEGQIGEQQSP 756
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKA----LLKQLAAL--------------------ERRIAALARR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  757 LAQLHTTLARALQQVKEKEVRAQKLADDLTTLQEKMASTSKVAAclktlvlKAGEQQEMTSLeLLKEPPGAGNKESNWLe 836
Cdd:COG4942    71 IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALY-------RLGRQPPLALL-LSPEDFLDAVRRLQYL- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  837 eqrggpfsspQAALKAMEQEAEQMGSELERLRvalmksqgQQQEERGQQEREVARLTRERSQAQADLAQEKAAKAELEVR 916
Cdd:COG4942   142 ----------KYLAPARREQAEELRADLAELA--------ALRAELEAERAELEALLAELEEERAALEALKAERQKLLAR 203

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 344240178  917 LQNTLNEQRVEFAALQEaldhaltEKEGKDQELAKLRGQEAAQRTE 962
Cdd:COG4942   204 LEKELAELAAELAELQQ-------EAEELEALIARLEAEAAAAAER 242
HemX COG2959
Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis ...
 523-595 8.30e-03

Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis) [General function prediction only];


Pssm-ID: 442199 [Multi-domain]  Cd Length: 361  Bit Score: 41.49  E-value: 8.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178  523 QTSVTQVQQEKAELSQKIEELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKVAEREkvmQEKAQLQEQLLAL 595
Cdd:COG2959    52 WQQLQQQQAELAQLAQQLAALQQQAQELRALAQQLQELLQQLAARLAQLEQRLAELQ---QQLAALQQLLQSL 121
Mt_ATP-synt_B pfam05405
Mitochondrial ATP synthase B chain precursor (ATP-synt_B); The Fo sector of the ATP synthase ...
 410-543 8.37e-03

Mitochondrial ATP synthase B chain precursor (ATP-synt_B); The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport. It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L).


Pssm-ID: 368426 [Multi-domain]  Cd Length: 163  Bit Score: 39.56  E-value: 8.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   410 ASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKeQQLEEAAKDQeaarqdhaqqLAIVAEAREASLRERDA 489
Cdd:pfam05405   40 EWLDKRIEKIQDELNQSRNLHEEALKERIEQVKKLQSVVELT-KVLFVVSKET----------VALEAEAFERELQAALA 108

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178   490 --ARQQLETLEKEKAAKLESLQQQLeaANEARDSVQTSVTQVQQEKAELSQKIEEL 543
Cdd:pfam05405  109 reIKSKLDTLVRKESSRRQREQDHL--VNWVISSVLKELSTPKFQKESLQESIADL 162
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 392-695 8.44e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 41.76  E-value: 8.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   392 ASLTALNTTLQ------QQQDQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQLSSSLKLKEQQLEEAAKD---- 461
Cdd:pfam06160   86 KALDEIEELLDdieediKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSYGPAIDELEKQLAEIEEEfsqf 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   462 -QEAARQDHAQQLAIVAEAREaslrERDAARQQLE-------TLEKEKAAKLESLQ---QQLEAANEARDSVQTS--VTQ 528
Cdd:pfam06160  166 eELTESGDYLEAREVLEKLEE----ETDALEELMEdipplyeELKTELPDQLEELKegyREMEEEGYALEHLNVDkeIQQ 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   529 VQQEKAELSQKIEELHacIEAAHQEQRQAQAHVTELEAQLKAEqqkVAEREKVMQEKAQLQEQLLALEETLQITKGSLEE 608
Cdd:pfam06160  242 LEEQLEENLALLENLE--LDEAEEALEEIEERIDQLYDLLEKE---VDAKKYVEKNLPEIEDYLEHAEEQNKELKEELER 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   609 EKHR---TADALAEQQrcvtKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLEEaRQAETEALRRELAEATASQH 685
Cdd:pfam06160  317 VQQSytlNENELERVR----GLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILE-QLEEIEEEQEEFKESLQSLR 391

                          330
                   ....*....|
gi 344240178   686 RAESESEQLI 695
Cdd:pfam06160  392 KDELEAREKL 401
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1301-1496 8.45e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1301 ELGPLRQKVAEQERAAQQLRAEKASYAEQL-SMLKKAHGLLAEENRGLGERANLGRQF--LEVELDQAREKYVQELAAV- 1376
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELeELNEEYNELQAELEALQAEIDKLQAEIaeAEAEIEERREELGERARALy 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178 1377 RTDAETHLAEMRQEAQSTTRELEVMTAkyegakVKVLEERQR-----FQEERQKLTAQVEELSKKLTEYDQASKVQQQKL 1451
Cdd:COG3883    97 RSGGSVSYLDVLLGSESFSDFLDRLSA------LSKIADADAdlleeLKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 344240178 1452 KAFQAQGGESQQEVQRLQAQLNELQTQLSQKEQAAEHYKLQMEKA 1496
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
MreC COG1792
Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome ...
 1498-1559 8.60e-03

Cell shape-determining protein MreC [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 441397  Cd Length: 282  Bit Score: 41.02  E-value: 8.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 344240178 1498 THYDAKKQQNQELQDQLRDLEQLQKENKELRAEAERLgRELqqagLKTKEAEQAcRHLSAQV 1559
Cdd:COG1792    68 RSLFNLREENERLKEENAELRAELQRLEELEAENARL-REL----LDLKERLDY-KFVAAEV 123
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 303-532 8.88e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 41.37  E-value: 8.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   303 ALQLETLKQEAAKLAAHNTQLQARIEtldcersQQEAQLLAERGHFEEEKQQLASLIADLQSSISNLSQAKEELEQASQA 382
Cdd:TIGR02794   49 AQQANRIQQQKKPAAKKEQERQKKLE-------QQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQA 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178   383 QGAQLTAQVASLTALNTTLQQQQDQELASLKEQAKKEQAQmvqslQEQEQAAQGLRQQVEQLSSSLKLKEQQL--EEAAK 460
Cdd:TIGR02794  122 EEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAA-----AEAKKKAEEAKKKAEAEAKAKAEAEAKAkaEEAKA 196

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 344240178   461 DQEAARQDHAQQLAIVAEArEASLRERDAARQQLETLEKEKAAKLES----LQQQLEAANEARDSVQTSVTQVQQE 532
Cdd:TIGR02794  197 KAEAAKAKAAAEAAAKAEA-EAAAAAAAEAERKADEAELGDIFGLASgsnaEKQGGARGAAAGSEVDKYAAIIQQA 271
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
655-778 8.97e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 41.19  E-value: 8.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  655 LEARLQQLEEARQAetealrrelAEATASQHRAESESEQLIR----EVESWQKRFEARQQEEARYSAMIQE--------- 721
Cdd:COG1566    81 LQAALAQAEAQLAA---------AEAQLARLEAELGAEAEIAaaeaQLAAAQAQLDLAQRELERYQALYKKgavsqqeld 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 344240178  722 ----QLAALKGDHEKAGQEAQEEAVEVHGEGQIGEQQSPLAQLHTTLARALQQVKEKEVRA 778
Cdd:COG1566   152 earaALDAAQAQLEAAQAQLAQAQAGLREEEELAAAQAQVAQAEAALAQAELNLARTTIRA 212
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 371-443 9.40e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 39.10  E-value: 9.40e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 344240178   371 QAKEELEQASQAQGAQLTAQVASLTALNTTLQQQQdQELASLKEQAKKEQAQMVQSLQEQEQAAQGLRQQVEQ 443
Cdd:pfam03938   19 AAQAQLEKKFKKRQAELEAKQKELQKLYEELQKDG-ALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQ 90
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 587-739 9.62e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 9.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 344240178  587 QLQEQLLALEEtLQITKGSLEEEKHRTADALAEQQRCVTKMEAESRSLMEQREQEQKALEQEKAGRKGLEARLQQLE--- 663
Cdd:COG1579    11 DLQELDSELDR-LEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRnnk 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 344240178  664 --EARQAETEALRRELAEATASQHRAESESEQLIREVESWQKRFEARQQEEARYSAMIQEQLAALKGDHEKAGQEAQE 739
Cdd:COG1579    90 eyEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREE 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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