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Conserved domains on  [gi|444729459|gb|ELW69875|]
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Reversion-inducing cysteine-rich protein with Kazal motif [Tupaia chinensis]

Protein Classification

CAP family protein( domain architecture ID 10143546)

CAP (CSP/antigen 5/PR1) family protein similar to human Golgi-associated plant pathogenesis related protein 1 (GAPR1) that forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids

PubMed:  18824526
SCOP:  4001882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 943-1074 5.99e-68

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


:

Pssm-ID: 349401  Cd Length: 132  Bit Score: 223.63  E-value: 5.99e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  943 EFNKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKHSPESSrgqCGENLAWAS---YDQTGKEVADRWY 1019
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSS---YGENLAYFSgsgYDLTGEEAVDSWY 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 444729459 1020 SEIKNYNFQQPGFTSGTGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNV 1074
Cdd:cd05382    78 NEIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 401-467 6.30e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17336:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 411  Bit Score: 49.93  E-value: 6.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444729459  401 CNCAD-QFVPVCGQNGRTYPSACIARC--VGLQDHQFEFG--SCISKDPCNPNPCQKNQRCIPRPQVCLTTF 467
Cdd:cd17336   316 CNCSDsSFSPVCGSDGITYFSPCHAGCtsSDAGNGTKTYSncSCINSGTATSSGCPPDCSVAPNCCSKLIPF 387
Amnionless super family cl28792
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 752-836 2.37e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


The actual alignment was detected with superfamily member pfam14828:

Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.61  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459   752 CAAV--KCPLLSatgCK-PIIPPGACCPLCAGMLRVLY-DKEKLDTI-AKVTNKkpITVLDILQKIRMHVS-VPQCDVFG 825
Cdd:pfam14828  209 CANVlqRCPPPH---CLsPLRPEGHCCDVCGAIVSLDYsSCFDLQTYrARLRHL--FLALPKYKGVQLAVSkVGKDQRLH 283

                           90
                   ....*....|.
gi 444729459   826 YLSIESEIVIL 836
Cdd:pfam14828  284 ISDNEIQIVIL 294
 
Name Accession Description Interval E-value
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 943-1074 5.99e-68

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 223.63  E-value: 5.99e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  943 EFNKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKHSPESSrgqCGENLAWAS---YDQTGKEVADRWY 1019
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSS---YGENLAYFSgsgYDLTGEEAVDSWY 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 444729459 1020 SEIKNYNFQQPGFTSGTGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNV 1074
Cdd:cd05382    78 NEIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 946-1070 8.45e-23

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 95.53  E-value: 8.45e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459    946 KEVLKAHNEYRKQHGV-----PPLTLCKKL--NREAQQYSEALASTRILKHSPesSRGQCGENLAWAS-----YDQTGKE 1013
Cdd:smart00198    4 QEILDAHNKLRSQVAGgflaaPAASNMLKLtwDCELASSAQNWANQCPFGHST--PRPGYGENLAWWSsstalPDTYASA 81

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 444729459   1014 VADRWYSEIKNYNFQQPGFT---SGTGHFTAMVWKNTKKMGVGKASASDGSS---FVVARYFP 1070
Cdd:smart00198   82 AVQLWYDEFQDYGYSSNTCKdtnGKIGHYTQVVWAKTYKVGCGVANCPDGTKkktVVVCNYDP 144
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 949-1065 2.19e-18

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 81.87  E-value: 2.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459   949 LKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKH-SPESSR-----GQCGENLAWASYDqTGKEVADRWYSEI 1022
Cdd:pfam00188    1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHrSPYGGNiyarvVAAGYALGDAGPD-SAEDAVDGWYDSP 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 444729459  1023 KNYNfqqpgftsgTGHFTAMVWKNTKKMGVGKASASDGSSFVV 1065
Cdd:pfam00188   80 GTYN---------CGHRTNLLWPKSTKVGCAVAKCGDGGTYYF 113
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 928-1068 5.39e-18

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 81.58  E-value: 5.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  928 GVEVSGCFAEQPASKEFNKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKH-SPESSR----------- 995
Cdd:COG2340     4 ALLLAAAAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHtGPDGSSpfdrlkaagys 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 444729459  996 -GQCGENLAWASydQTGKEVADRWYSEiknynfqqpgftsgTGHFTAMVWKNTKKMGVGKASASDGSSFVVARY 1068
Cdd:COG2340    84 yRAAGENIAAGY--STAEEAVDGWMNS--------------PGHRANILNPDFTEIGVGVAYGGDGGVYWTQVF 141
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 401-467 6.30e-06

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 49.93  E-value: 6.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444729459  401 CNCAD-QFVPVCGQNGRTYPSACIARC--VGLQDHQFEFG--SCISKDPCNPNPCQKNQRCIPRPQVCLTTF 467
Cdd:cd17336   316 CNCSDsSFSPVCGSDGITYFSPCHAGCtsSDAGNGTKTYSncSCINSGTATSSGCPPDCSVAPNCCSKLIPF 387
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 752-836 2.37e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.61  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459   752 CAAV--KCPLLSatgCK-PIIPPGACCPLCAGMLRVLY-DKEKLDTI-AKVTNKkpITVLDILQKIRMHVS-VPQCDVFG 825
Cdd:pfam14828  209 CANVlqRCPPPH---CLsPLRPEGHCCDVCGAIVSLDYsSCFDLQTYrARLRHL--FLALPKYKGVQLAVSkVGKDQRLH 283

                           90
                   ....*....|.
gi 444729459   826 YLSIESEIVIL 836
Cdd:pfam14828  284 ISDNEIQIVIL 294
 
Name Accession Description Interval E-value
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 943-1074 5.99e-68

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 223.63  E-value: 5.99e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  943 EFNKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKHSPESSrgqCGENLAWAS---YDQTGKEVADRWY 1019
Cdd:cd05382     1 VFQKECLKAHNEYRALHGAPPLKLDKELSKEAQKWAEKLASSGTLQHSSPSS---YGENLAYFSgsgYDLTGEEAVDSWY 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 444729459 1020 SEIKNYNFQQPGFTSGTGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNV 1074
Cdd:cd05382    78 NEIKNYNFNKPGFQSGTGHFTQVVWKSSTELGVGVAKSKDGCVYVVARYSPAGNV 132
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 947-1069 1.06e-48

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 168.95  E-value: 1.06e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  947 EVLKAHNEYRKQH-----GVPPLTLCKKLNREAQQYSEALastrILKHSPESSRGQCGENLAWASYDQTGKEVADRWYSE 1021
Cdd:cd00168     3 EILDLHNSYRSSVsppasNMPLMAWDQELADVAIGYAKDC----IFSHSSPTSRQLAGENIAASSYDMDGVAALQAWHNE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 444729459 1022 IKNYNFQ--QPGFTSGTGHFTAMVWKNTKKMGVGKASASDGSSFVVARYF 1069
Cdd:cd00168    79 IKNYNFGtaQPGFNSGTGHYTQMVWEKTTKLGCGVADCSDNSKFVVCNYI 128
CAP_PRY1-like cd05384
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 943-1076 5.55e-34

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349403  Cd Length: 129  Bit Score: 127.06  E-value: 5.55e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  943 EFNKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKHSPessrGQCGENLAwASYdQTGKEVADRWYSEI 1022
Cdd:cd05384     1 SFASSILDAHNKKRALHGTQPLTWNDTLAEYAQDYADSYDCSGNLVHSG----GPYGENLA-LGY-SSGAAAVDAWYDEI 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 444729459 1023 KNYNFQQPGFTSGTGHFTAMVWKNTKKMGVG-KASASDGSSFVVARYFPAGNVVN 1076
Cdd:cd05384    75 SDYDYSNPGFSESTGHFTQLVWKSTTQVGCAyKDCGGAWGLYIVCEYDPAGNVIG 129
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 946-1077 5.91e-24

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 98.47  E-value: 5.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  946 KEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYsealASTRILKHSPESSRGQCGENLAWASYDQ-TGKEVADRWYSEIKN 1024
Cdd:cd05381     2 QDFLDAHNQARAAVGVPPLVWDDTLAAYAQKY----ANQRRGDCSLVHSNGPYGENLFWGSGDNwSPADAVKSWVDEKPY 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444729459 1025 YNfqqpgFTSGT-------GHFTAMVWKNTKKMGVGKASAS-DGSSFVVARYFPAGNVVNQ 1077
Cdd:cd05381    78 YD-----YASNTcvggkmcGHYTQVVWRNSTRLGCARVVCDnNGGTFVICNYDPPGNYIGE 133
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 946-1070 8.45e-23

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 95.53  E-value: 8.45e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459    946 KEVLKAHNEYRKQHGV-----PPLTLCKKL--NREAQQYSEALASTRILKHSPesSRGQCGENLAWAS-----YDQTGKE 1013
Cdd:smart00198    4 QEILDAHNKLRSQVAGgflaaPAASNMLKLtwDCELASSAQNWANQCPFGHST--PRPGYGENLAWWSsstalPDTYASA 81

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 444729459   1014 VADRWYSEIKNYNFQQPGFT---SGTGHFTAMVWKNTKKMGVGKASASDGSS---FVVARYFP 1070
Cdd:smart00198   82 AVQLWYDEFQDYGYSSNTCKdtnGKIGHYTQVVWAKTYKVGCGVANCPDGTKkktVVVCNYDP 144
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 946-1068 2.56e-22

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 94.06  E-value: 2.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  946 KEVLKAHNEYRKQH------------GVPPLTLCKKLNREAQQYsealASTRILKHSPESSRGQCGENLAWASY-----D 1008
Cdd:cd05380     2 QEILDAHNELRSKVakgklkglppaaNMPKLKWDCELAKLAQNW----AKTCVFAHSPCRNTGGVGQNLASVSSsgkdlK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 444729459 1009 QTGKEVADRWYSEIKNYNFQQ---PGFTSGTGHFTAMVWKNTKKMGVGKASASDGS---SFVVARY 1068
Cdd:cd05380    78 ELIEDAVNAWFDELKDYGFGSnpnNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGgnkTYVVCNY 143
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 949-1065 2.19e-18

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 81.87  E-value: 2.19e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459   949 LKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKH-SPESSR-----GQCGENLAWASYDqTGKEVADRWYSEI 1022
Cdd:pfam00188    1 LDLHNEYRAAAGLPPLSWDNELAAAAQDHAKYCADNGSHNHrSPYGGNiyarvVAAGYALGDAGPD-SAEDAVDGWYDSP 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 444729459  1023 KNYNfqqpgftsgTGHFTAMVWKNTKKMGVGKASASDGSSFVV 1065
Cdd:pfam00188   80 GTYN---------CGHRTNLLWPKSTKVGCAVAKCGDGGTYYF 113
YkwD COG2340
Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell ...
 928-1068 5.39e-18

Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain [Cell cycle control, cell division, chromosome partitioning, General function prediction only];


Pssm-ID: 441910  Cd Length: 144  Bit Score: 81.58  E-value: 5.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  928 GVEVSGCFAEQPASKEFNKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKH-SPESSR----------- 995
Cdd:COG2340     4 ALLLAAAAAAPAALSALEQEVLELVNAYRAAAGLPPLTWDPRLTAAARAHAQDMAENGYFSHtGPDGSSpfdrlkaagys 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 444729459  996 -GQCGENLAWASydQTGKEVADRWYSEiknynfqqpgftsgTGHFTAMVWKNTKKMGVGKASASDGSSFVVARY 1068
Cdd:COG2340    84 yRAAGENIAAGY--STAEEAVDGWMNS--------------PGHRANILNPDFTEIGVGVAYGGDGGVYWTQVF 141
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 946-1071 2.41e-15

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 73.93  E-value: 2.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  946 KEVLKAHNEYRKQHGVPPLTLCK-KLNREAQQYSEALASTRILKHSPESSR----GQCGENLAWASYDQTGKEVADRWYS 1020
Cdd:cd05383     4 QEIVDLHNALRRSVNPPASNMLKmSWNPEAAENAQRWANRCNFTHSPPNGRtipgIRCGENIFMSSYPASWSEVIQAWYD 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 444729459 1021 EIKNYNFQ----QPGftSGTGHFTAMVWKNTKKMGVGKASASDGSS---FVVARYFPA 1071
Cdd:cd05383    84 EYKDFKYGvgakPPG--SVTGHYTQVVWYSSYLVGCAVAYCPSQGSlkyFYVCQYCPA 139
CAP_bacterial cd05379
Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 945-1065 4.42e-13

Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.


Pssm-ID: 349398  Cd Length: 120  Bit Score: 67.02  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  945 NKEVLKAHNEYRKQHGVPPLTLCKKLNREAQQYSEALASTRILKHSPESSRGQC-----------GENLAWASYdqTGKE 1013
Cdd:cd05379     1 EQEVLELINEYRAKAGLPPLSWDPRLEKAAQDHAEDMAANGYFSHTGPDGSSDRaaragywyrgaGENIAYGQG--SAEE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 444729459 1014 VADRWYSEIknynfqqpgftsgtGHFTAMVWKNTKKMGVGKASASDGSSFVV 1065
Cdd:cd05379    79 AVNQWINSP--------------GHRANILDPDFTEIGVGVAYNSSGGTYWT 116
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 946-1053 1.72e-11

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 62.82  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  946 KEVLKAHNEYRKQHGvPPLTLCKKL--NREAQQYSEALASTRILKHSPEssRGQCGENL-AWASYDQTGKEVADRWYSEI 1022
Cdd:cd05559     2 KLLVDLHNQYRSQVS-PSAANMLKMtwDTELEALAKAYARKCIWEHNPD--RGRVGENLfASTGKPLDVELAVEDWHNEK 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 444729459 1023 KNYNFQQPGFTSGT--GHFTAMVWKNTKKMGVG 1053
Cdd:cd05559    79 EYYNFETKTCAPGKmcGHYTQVVWANTEKIGCG 111
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 943-1072 2.03e-07

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 51.64  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  943 EFNKEVLKAHNEYRKqhGV-PPLTLCKKL--NREAQQYSEALASTRILKHSPESS-RGQC-------GENLaW--ASYDQ 1009
Cdd:cd05385     1 AFIDECVRIHNELRS--KVsPPAANMRYMswDKALAKTARAWARKCKFSHNICLKePGKChpnfttlGENI-WlgSIFSF 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444729459 1010 TGKEVADRWYSEIKNYNFQQPGFTSGTGHFTAMVWKNTKKMGVGKASASDGSSFV--------VARYFPAG 1072
Cdd:cd05385    78 SVESAITSWYNEVKDYNFKTNSCSRVCGHYTQVVWADSYKVGCAVHVCPNGGGFFsgsssaifVCNYGPAG 148
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 401-467 6.30e-06

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 49.93  E-value: 6.30e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 444729459  401 CNCAD-QFVPVCGQNGRTYPSACIARC--VGLQDHQFEFG--SCISKDPCNPNPCQKNQRCIPRPQVCLTTF 467
Cdd:cd17336   316 CNCSDsSFSPVCGSDGITYFSPCHAGCtsSDAGNGTKTYSncSCINSGTATSSGCPPDCSVAPNCCSKLIPF 387
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 946-1051 1.25e-05

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 46.13  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  946 KEVLKAHNEYRKQhgVPP-------LTLCKKLNREAqqysEALASTRILKHSPESSRGQCGENLA--WASYDQTGKEVaD 1016
Cdd:cd18816     2 EEILQLHNKLRGQ--VYPsasnmeyMTWDDELERSA----EAWAQQCIWEHGPTSLLPSIGQNLAvhWGRYRSPAFHV-Q 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 444729459 1017 RWYSEIKNYNFQQPG--------FTSG--TGHFTAMVWKNTKKMG 1051
Cdd:cd18816    75 SWYDEVKDYTYPYPHecnpwcpeRCSGpmCTHYTQIVWATTNKVG 119
CAP_PI15-like cd18812
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 947-1051 3.65e-04

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349406  Cd Length: 146  Bit Score: 41.81  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  947 EVLKAHNEYRKQHgVPP------LTLCKKLNREAqqysEALASTRILKHSPESSRGQCGENLA--WASYDQTGKEVADrW 1018
Cdd:cd18812     3 AILDYHNKLRGQV-YPPaanmeyMVWDKELARSA----EAWATQCIWEHGPSSLLRSIGQNLSahWGRYRSPVFLVKS-W 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 444729459 1019 YSEIKNYNFQQPG----------FTSGTGHFTAMVWKNTKKMG 1051
Cdd:cd18812    77 YDEVKDYLFPYPRdcnphcpwrcSGPMCTHYTQMVWATSNRIG 119
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 752-836 2.37e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.61  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459   752 CAAV--KCPLLSatgCK-PIIPPGACCPLCAGMLRVLY-DKEKLDTI-AKVTNKkpITVLDILQKIRMHVS-VPQCDVFG 825
Cdd:pfam14828  209 CANVlqRCPPPH---CLsPLRPEGHCCDVCGAIVSLDYsSCFDLQTYrARLRHL--FLALPKYKGVQLAVSkVGKDQRLH 283

                           90
                   ....*....|.
gi 444729459   826 YLSIESEIVIL 836
Cdd:pfam14828  284 ISDNEIQIVIL 294
CAP_PI15 cd18814
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 948-1051 3.54e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15; Peptidase inhibitor 15 (PI15) is also called 25 kDa trypsin inhibitor (p25TI), cysteine-rich secretory protein 8 (CRISP-8), or SugarCrisp. It is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. PI15 may also participate in the regulation of drug resistance in ovarian cancer and serve as a potential target in targeted therapies. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349408  Cd Length: 146  Bit Score: 39.21  E-value: 3.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  948 VLKAHNEYRKQHgVPPLTLCKKL--NREAQQYSEALASTRILKHSPESSRGQCGENLAWasydQTGK-----EVADRWYS 1020
Cdd:cd18814     4 ILDYHNQVRGKV-FPPAANMEYMvwDENLAKSAEAWAATCIWDHGPSYLLRFLGQNLSV----RTGRyrsilQLVKPWYD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 444729459 1021 EIKNYNFQQPG----------FTSGTGHFTAMVWKNTKKMG 1051
Cdd:cd18814    79 EVKDYAFPYPQdcnprcplrcYGPMCTHYTQMVWATSNRIG 119
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
 401-426 5.59e-03

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....*..
gi 444729459  401 CNCAD-QFVPVCGQNGRTYPSACIARC 426
Cdd:cd17457   357 CNCDEsQWDPVCGNNGITYISACLAGC 383
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 400-444 7.59e-03

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 40.22  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 444729459  400 PCNCA-DQFVPVCGQNGRTYPSACIARC---VGL-QDHQFEFGSCISKDP 444
Cdd:cd17458   428 DCDCPlKVWDPVCGNNGLTYVSACLAGCkasVGTgKNMVFQNCSCVAASG 477
CAP_CRISPLD1 cd18813
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 946-1051 9.67e-03

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349407  Cd Length: 146  Bit Score: 37.68  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444729459  946 KEVLKAHNEYRKQHgVPPLTLCKKL--NREAQQYSEALASTRILKHSPESSRGQCGENLA--WASYDQTGKEVaDRWYSE 1021
Cdd:cd18813     2 QLILDLHNKLRGQV-YPPASNMEYMtwDVELERSAEAWAETCLWEHGPAHLLPSIGQNLGahWGRYRPPTFHV-QAWYDE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 444729459 1022 IKNYNFQQPG--------FTSG--TGHFTAMVWKNTKKMG 1051
Cdd:cd18813    80 VRDFSYPYPQecnpycpfRCSGpvCTHYTQVVWATSNRIG 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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