|
Name |
Accession |
Description |
Interval |
E-value |
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
407-714 |
0e+00 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 654.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 407 NLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAG 486
Cdd:cd17757 1 NLVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 487 LTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG 566
Cdd:cd17757 81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 567 RYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRLYSLDEIRRYLLFARQFKPKISS 646
Cdd:cd17757 161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKLTK 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012734757 647 ESEEFIVEQYKRLRQRDASGGvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:cd17757 241 EAKDELVEQYKELRQDDASGS-TRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
361-714 |
0e+00 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 534.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 361 VAPTNPRFGGKELRDEEQT---AESIK---------------SQMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEV 422
Cdd:smart00350 132 NVPYGFKLNTVKGLPVFATyieANHVRkldykrsfedssfsvQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDI 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 423 KRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVRDEESHEFVI 502
Cdd:smart00350 212 KKAILLLLFGGVHKNLPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTL 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 503 EAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTA 582
Cdd:smart00350 292 EAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPA 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 583 PIMSRFDLFFILVDECNEVTDYAIARRIVDLH----SRVEESVDRLYSLDEIRRYLLFAR-QFKPKISSESEEFIVEQYK 657
Cdd:smart00350 372 PILSRFDLLFVVLDEVDEERDRELAKHVVDLHryshPEEDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYV 451
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1012734757 658 RLRQRDASGGvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:smart00350 452 DLRKEDSQTE-SRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRES 507
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
391-614 |
2.24e-141 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 421.17 E-value: 2.24e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 391 EWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEF 470
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 471 SPRAVYTSGKASTAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKAT 550
Cdd:pfam00493 81 APRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVAT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012734757 551 LNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH 614
Cdd:pfam00493 161 LNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| minchrom_main_MCM |
NF040949 |
minichromosome maintenance protein MCM; |
386-710 |
7.78e-132 |
|
minichromosome maintenance protein MCM;
Pssm-ID: 468880 [Multi-domain] Cd Length: 681 Bit Score: 413.17 E-value: 7.78e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 386 QMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLK 465
Cdd:NF040949 263 EITEEDEEKILELAKDPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQ 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 466 HVEEFSPRAVYTSGKASTAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKA 545
Cdd:NF040949 343 YVARLAPRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKA 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 546 GVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRLy 625
Cdd:NF040949 423 GIVATLNARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEI- 501
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 626 SLDEIRRYLLFARQF-KPKISSESEEFIVEQYKRLRQRDASGGVSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHV 704
Cdd:NF040949 502 DPDLLKKYIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDPDSPIPITARQLEALIRLSEAHAKMRLKDEVTAEDA 581
|
....*.
gi 1012734757 705 KEAFRL 710
Cdd:NF040949 582 ERAIRL 587
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
376-710 |
1.60e-131 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 412.27 E-value: 1.60e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 376 EEQTAESIksQMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGD 455
Cdd:COG1241 246 EEKEFEEI--EITEEDEEKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGD 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 456 PSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVRDEESH-EFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEA 534
Cdd:COG1241 324 PGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGTgRWTLEAGALVLADGGLACIDELDKMREEDRSALHEA 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 535 MEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH 614
Cdd:COG1241 404 MEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVH 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 615 SRVE----------ESVDRLYSLDEIRRYLLFARQF-KPKISSESEEFIVEQYKRLRQRDASGGvskSAWRITVRQLESM 683
Cdd:COG1241 484 RAGElleqeieeetEEVKPEIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDED---SPVPITARQLEAL 560
|
330 340
....*....|....*....|....*..
gi 1012734757 684 IRLSEAMARMHCCDEVQPKHVKEAFRL 710
Cdd:COG1241 561 IRLAEASARMRLSDTVTEEDAERAIRL 587
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
388-714 |
1.18e-77 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 273.02 E-value: 1.18e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 388 TEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTT---------MEGTSLRGDVNVCIVGDPST 458
Cdd:PTZ00111 424 SDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSdfnkspdacYKVDNFRGIINVLLCGDPGT 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 459 AKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAV-VRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQ 537
Cdd:PTZ00111 504 AKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQ 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 538 QTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIA---------- 607
Cdd:PTZ00111 584 QTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISlsiakdfllp 663
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 608 ----------------RRIVDLHSRVEESVDRLYSLDEIRRYLLFAR-QFKPKISSESEEFIVEQYKRLRQ--------- 661
Cdd:PTZ00111 664 hmtgsgndedtydrsnTMHVEDESLRSEKDYNKNDLDMLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQgnfqtsnld 743
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012734757 662 --------RDASGGVSKSAWR---ITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:PTZ00111 744 elehaqedDDDDLYYQSSGTRmiyVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
|
|
| MCM6_C |
pfam18263 |
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the ... |
893-984 |
6.03e-26 |
|
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD.
Pssm-ID: 465688 Cd Length: 107 Bit Score: 103.05 E-value: 6.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 893 PSLRLSFAEYKRISNLLVLHLRRAEEAEEEEeLTKTAVVNWYLKEIEAEIDSEEELINRKGLIEKVIHRLVHyDHILIEL 972
Cdd:pfam18263 1 KKLRITYDKYVKIMNLLVLHLREVEEEEGEG-VDRSELIQWYLEQIEDEIESEEELEEEKELVEKVIKRLIK-DNILLEI 78
|
90
....*....|..
gi 1012734757 973 SRAGLKGSESQS 984
Cdd:pfam18263 79 RGEGLEDEGEED 90
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
75-234 |
7.73e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 46.68 E-value: 7.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 75 ADQAREKHPPGELLRPGGLQPGAGHHHPGGVLQGVPLPLPGCAQLR-QGS--WERPPQQGVLRChrrSAHQTQDPGAVLH 151
Cdd:pfam03154 162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPpQGSpaTSQPPNQTQSTA---APHTLIQQTPTLH 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 152 ANWHPGEdqRPGGEDAPGPPGAGERYLPVHGLPGAHQRRPPAVQVLAA--DHLQEPRLQQPLPLPPRHAQVQVHRLPEGT 229
Cdd:pfam03154 239 PQRLPSP--HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTgpSHMQHPVPPQPFPLTPQSSQSQVPPGPSPA 316
|
....*
gi 1012734757 230 DPGDS 234
Cdd:pfam03154 317 APGQS 321
|
|
| KLF9_13_N-like |
cd21975 |
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
147-251 |
6.21e-03 |
|
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.
Pssm-ID: 409240 [Multi-domain] Cd Length: 163 Bit Score: 38.52 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 147 GAVLHAnwhpgedQRPGGEDAPGPPG----AGERYLPVHGLPGAHQRR---PPAVQVLAADHLQEPRLQQPLPLPPRHAQ 219
Cdd:cd21975 15 GAVVHG-------VRPDPEGAGLAAGldvrATREVAKGPGPPGPAWKPdgaDSPGLVTAAPHLLAANVLAPLRGPSVEGS 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1012734757 220 VQVHRL---------------PEGTDPGDSGGAASGVHPALSGHHPA 251
Cdd:cd21975 88 SLESGDadmgsdsdvapasgaAASTSPESSSDAASSPSPLSLLHPGE 134
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
407-714 |
0e+00 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 654.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 407 NLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAG 486
Cdd:cd17757 1 NLVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 487 LTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG 566
Cdd:cd17757 81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 567 RYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRLYSLDEIRRYLLFARQFKPKISS 646
Cdd:cd17757 161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKLTK 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012734757 647 ESEEFIVEQYKRLRQRDASGGvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:cd17757 241 EAKDELVEQYKELRQDDASGS-TRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
361-714 |
0e+00 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 534.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 361 VAPTNPRFGGKELRDEEQT---AESIK---------------SQMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEV 422
Cdd:smart00350 132 NVPYGFKLNTVKGLPVFATyieANHVRkldykrsfedssfsvQSLSDEEEEEIRKLSKDPDIYERLARSLAPSIYGHEDI 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 423 KRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVRDEESHEFVI 502
Cdd:smart00350 212 KKAILLLLFGGVHKNLPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTL 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 503 EAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTA 582
Cdd:smart00350 292 EAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPA 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 583 PIMSRFDLFFILVDECNEVTDYAIARRIVDLH----SRVEESVDRLYSLDEIRRYLLFAR-QFKPKISSESEEFIVEQYK 657
Cdd:smart00350 372 PILSRFDLLFVVLDEVDEERDRELAKHVVDLHryshPEEDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYV 451
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1012734757 658 RLRQRDASGGvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:smart00350 452 DLRKEDSQTE-SRSSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRES 507
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
411-711 |
5.60e-142 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 425.99 E-value: 5.60e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 411 SLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAA 490
Cdd:cd17706 5 SIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGLTAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 491 VVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDR 570
Cdd:cd17706 85 VVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGRYNP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 571 SKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHS-------RVEESVDRLYSLDEIRRYLLFARQFKPK 643
Cdd:cd17706 165 KLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRgsdpeeqVKPEEDGIPIDIELLRKYILYARQIHPK 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012734757 644 ISSESEEFIVEQYKRLRQRDAsggvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLL 711
Cdd:cd17706 245 ISEEAREKLVRWYVELRKESE----RRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLV 308
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
391-614 |
2.24e-141 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 421.17 E-value: 2.24e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 391 EWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEF 470
Cdd:pfam00493 1 DEEEIKELAKRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 471 SPRAVYTSGKASTAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKAT 550
Cdd:pfam00493 81 APRAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVAT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012734757 551 LNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH 614
Cdd:pfam00493 161 LNARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
|
|
| minchrom_main_MCM |
NF040949 |
minichromosome maintenance protein MCM; |
386-710 |
7.78e-132 |
|
minichromosome maintenance protein MCM;
Pssm-ID: 468880 [Multi-domain] Cd Length: 681 Bit Score: 413.17 E-value: 7.78e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 386 QMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLK 465
Cdd:NF040949 263 EITEEDEEKILELAKDPWIREKIIASIAPSIYGHWEIKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQ 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 466 HVEEFSPRAVYTSGKASTAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKA 545
Cdd:NF040949 343 YVARLAPRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKA 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 546 GVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRLy 625
Cdd:NF040949 423 GIVATLNARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEI- 501
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 626 SLDEIRRYLLFARQF-KPKISSESEEFIVEQYKRLRQRDASGGVSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHV 704
Cdd:NF040949 502 DPDLLKKYIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDPDSPIPITARQLEALIRLSEAHAKMRLKDEVTAEDA 581
|
....*.
gi 1012734757 705 KEAFRL 710
Cdd:NF040949 582 ERAIRL 587
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
376-710 |
1.60e-131 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 412.27 E-value: 1.60e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 376 EEQTAESIksQMTEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGD 455
Cdd:COG1241 246 EEKEFEEI--EITEEDEEKIKELSKDPDIYEKIIASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGD 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 456 PSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAVVRDEESH-EFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEA 534
Cdd:COG1241 324 PGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGTgRWTLEAGALVLADGGLACIDELDKMREEDRSALHEA 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 535 MEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH 614
Cdd:COG1241 404 MEQQTISIAKAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVH 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 615 SRVE----------ESVDRLYSLDEIRRYLLFARQF-KPKISSESEEFIVEQYKRLRQRDASGGvskSAWRITVRQLESM 683
Cdd:COG1241 484 RAGElleqeieeetEEVKPEIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDED---SPVPITARQLEAL 560
|
330 340
....*....|....*....|....*..
gi 1012734757 684 IRLSEAMARMHCCDEVQPKHVKEAFRL 710
Cdd:COG1241 561 IRLAEASARMRLSDTVTEEDAERAIRL 587
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
407-714 |
3.40e-125 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 382.89 E-value: 3.40e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 407 NLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAG 486
Cdd:cd17756 1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 487 LTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG 566
Cdd:cd17756 81 LTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 567 RYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH-----SRVEESVDRLYSLDEIRRYLLFAR-QF 640
Cdd:cd17756 161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHasarkASQSQENEGEIPISKLKRYIAYCRaKC 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012734757 641 KPKISSESEEFIVEQYKRLRQ---RDASGGVSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:cd17756 241 APRLSEEAAEKLSNHYVTIRKdvrQNELESDNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
411-711 |
5.89e-115 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 355.61 E-value: 5.89e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 411 SLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAA 490
Cdd:cd17761 6 SIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGLTAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 491 VVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDR 570
Cdd:cd17761 86 VVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKFGRFDS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 571 SKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDR-LYSLDEIRRYLLFARQF-KPKISSES 648
Cdd:cd17761 166 YRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGEMREIKpEIDPDLLRKYIAYARKNvRPVLTEEA 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012734757 649 EEFIVEQYKRLRQRDASggvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLL 711
Cdd:cd17761 246 KQLIKDFYVEMRKSGQE---TPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIM 305
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
411-714 |
2.76e-114 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 354.45 E-value: 2.76e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 411 SLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGLTAA 490
Cdd:cd17753 5 SIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 491 VVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDR 570
Cdd:cd17753 85 VRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYNP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 571 SKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESVDRLYSLDE--------------------I 630
Cdd:cd17753 165 TLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHPENDEDREGEEeknqrqrpketkvepipqelL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 631 RRYLLFARQ-FKPKISSESEEFIVEQYKRLRQR-DASGGVSksawrITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAF 708
Cdd:cd17753 245 RKYIHYAREkVRPKLNQMDMDKVSRVYADLRKEsMATGSLP-----ITVRHLESIIRISEAHAKMHLREYVSEEDVDMAI 319
|
....*.
gi 1012734757 709 RLLNKS 714
Cdd:cd17753 320 RVMLDS 325
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
408-711 |
9.20e-114 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 352.51 E-value: 9.20e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 408 LCTSLFPTIHGNDEVKRGILLMLFGGVPKT-TMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAG 486
Cdd:cd17755 2 LARSIAPSIYELEDVKKGILLQLFGGTRKDfTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 487 LTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG 566
Cdd:cd17755 82 LTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 567 RYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH--SRVEESVDRLYSLDEIRRYLLFARQ-FKPK 643
Cdd:cd17755 162 RYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLYleDTPEHIQDEVLDVEVLTDYISYAREhIHPK 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012734757 644 ISSESEEFIVEQYKRLRQRDASGGVSKSAwriTVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLL 711
Cdd:cd17755 242 LSEEAAQELVQAYVDMRKMGSDARKRITA---TPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLI 306
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
408-714 |
7.79e-107 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 333.99 E-value: 7.79e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 408 LCTSLFPTIHGNDEVKRGILLMLFGGVPKTTmEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGL 487
Cdd:cd17758 2 LAASIAPEIYGHEDVKKALLLLLVGGVDKRG-DGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 488 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGR 567
Cdd:cd17758 81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 568 YDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEE--SVDRLYSLDEIRRYLLFARQFKPKIS 645
Cdd:cd17758 161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQpdSDFEPLDPKLLRAYIALAKRKRPTVP 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1012734757 646 SESEEFIVEQYKRLRQRDASggvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:cd17758 241 PALADYIVQAYVEMRQEAKR---SKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
408-712 |
1.87e-104 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 327.50 E-value: 1.87e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 408 LCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGL 487
Cdd:cd17754 2 LSKSLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 488 TAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGR 567
Cdd:cd17754 82 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYGR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 568 YDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEesvdrlysldEIRRYLLFARQ-FKPKISS 646
Cdd:cd17754 162 YDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRYIK----------FLRKYIHYAKErIKPKLTQ 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1012734757 647 ESEEFIVEQYKRLRQRDASGGVSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLN 712
Cdd:cd17754 232 EAAEYIAEEYADLRNDDNTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLR 297
|
|
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
408-714 |
1.07e-86 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 280.20 E-value: 1.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 408 LCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGTSLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAAGL 487
Cdd:cd17760 2 ILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 488 TAAVVRDeeSHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPvSGR 567
Cdd:cd17760 82 TVTAVKD--GGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 568 YDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRVEESvDRLYSLDEIRRYLLFARQFKPKISSE 647
Cdd:cd17760 159 YDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKS-SKLWSMEKMRTYFCLIKNLRPVLSDE 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012734757 648 SEEFIVEQYKRLRQRDasggvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:cd17760 238 ANAILLRYYQLQRQSD-----CRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
|
|
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
408-714 |
1.08e-82 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 269.02 E-value: 1.08e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 408 LCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGT--SLRGDVNVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASTAA 485
Cdd:cd17759 2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNriPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 486 GLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQvAIHEAMEQQTISITKAGVKATLNARTSILAAANPVS 565
Cdd:cd17759 82 GLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGSQHQ-ALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 566 GRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYaiarrIVDLHSRVeesvdrlysldeIRRYLLFARQF-KPKI 644
Cdd:cd17759 161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDH-----LLSEHHQL------------LRKYISYARQYvNPVL 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 645 SSESEEFIVEQYKRLRQRDASGGVSKsawrITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:cd17759 224 SKDASEALQEFYLELRKQNQLADSSP----ITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
388-714 |
1.18e-77 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 273.02 E-value: 1.18e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 388 TEKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTT---------MEGTSLRGDVNVCIVGDPST 458
Cdd:PTZ00111 424 SDLQVYKILELSRNPMIYRILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSdfnkspdacYKVDNFRGIINVLLCGDPGT 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 459 AKSQFLKHVEEFSPRAVYTSGKASTAAGLTAAV-VRDEESHEFVIEAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQ 537
Cdd:PTZ00111 504 AKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQ 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 538 QTISITKAGVKATLNARTSILAAANPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDECNEVTDYAIA---------- 607
Cdd:PTZ00111 584 QTVTIAKAGIVATLKAETAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISlsiakdfllp 663
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 608 ----------------RRIVDLHSRVEESVDRLYSLDEIRRYLLFAR-QFKPKISSESEEFIVEQYKRLRQ--------- 661
Cdd:PTZ00111 664 hmtgsgndedtydrsnTMHVEDESLRSEKDYNKNDLDMLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQgnfqtsnld 743
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012734757 662 --------RDASGGVSKSAWR---ITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKS 714
Cdd:PTZ00111 744 elehaqedDDDDLYYQSSGTRmiyVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
628-714 |
3.92e-34 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 125.73 E-value: 3.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 628 DEIRRYLLFAR-QFKPKISSESEEFIVEQYKRLRQRDASggvSKSAWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKE 706
Cdd:pfam17855 1 ELLRKYIAYAReKIKPKLSEEAREKLVDAYVELRKESTG---SGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEE 77
|
....*...
gi 1012734757 707 AFRLLNKS 714
Cdd:pfam17855 78 AIRLLKES 85
|
|
| MCM6_C |
pfam18263 |
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the ... |
893-984 |
6.03e-26 |
|
MCM6 C-terminal winged-helix domain; The minichromosome maintenance (Mcm) complex is the replicative helicase in eukaryotic species, that plays essential roles in the initiation and elongation phases of DNA replication. During late M and early G(1), the Mcm complex is loaded onto chromatin to form prereplicative complex in a Cdt1-dependent manner. This entry represents the C-terminal domain of human Mcm6 which is the Cdt1 binding domain (CBD). The structure of CBD exhibits a typical winged helix fold that is generally involved in protein-nucleic acid interaction. The CBD failed to interact with DNA in experiments. The CBD-Cdt1 interaction involves the helix-turn-helix motif of CBD.
Pssm-ID: 465688 Cd Length: 107 Bit Score: 103.05 E-value: 6.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 893 PSLRLSFAEYKRISNLLVLHLRRAEEAEEEEeLTKTAVVNWYLKEIEAEIDSEEELINRKGLIEKVIHRLVHyDHILIEL 972
Cdd:pfam18263 1 KKLRITYDKYVKIMNLLVLHLREVEEEEGEG-VDRSELIQWYLEQIEDEIESEEELEEEKELVEKVIKRLIK-DNILLEI 78
|
90
....*....|..
gi 1012734757 973 SRAGLKGSESQS 984
Cdd:pfam18263 79 RGEGLEDEGEED 90
|
|
| PRK09862 |
PRK09862 |
ATP-dependent protease; |
503-707 |
3.05e-07 |
|
ATP-dependent protease;
Pssm-ID: 182120 [Multi-domain] Cd Length: 506 Bit Score: 54.22 E-value: 3.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 503 EAGALMLADNGVCCIDEFDKMDIKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANP-----VSGRYDRS---KSL 574
Cdd:PRK09862 286 GPGEISLAHNGVLFLDELPEFERRTLDALREPIESGQIHLSRTRAKITYPARFQLVAAMNPsptghYQGNHNRCtpeQTL 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 575 KQNVNLTAPIMSRFDLFF--------ILVDECNE-VTDYAIARRIVDLHSRVEESVDRLYS-LD--EIRRYLlfarqfkp 642
Cdd:PRK09862 366 RYLNRLSGPFLDRFDLSLeiplpppgILSKTVVPgESSATVKQRVMAARERQFKRQNKLNAwLDspEIRQFC-------- 437
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1012734757 643 KISSESEEFIVEQYKRLrqrdasgGVSKSAWritvrqlESMIRLSEAMARMHCCDEVQPKHVKEA 707
Cdd:PRK09862 438 KLESEDARWLEETLIHL-------GLSIRAW-------QRLLKVARTIADIDQSDIITRQHLQEA 488
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
75-234 |
7.73e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 46.68 E-value: 7.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 75 ADQAREKHPPGELLRPGGLQPGAGHHHPGGVLQGVPLPLPGCAQLR-QGS--WERPPQQGVLRChrrSAHQTQDPGAVLH 151
Cdd:pfam03154 162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPpQGSpaTSQPPNQTQSTA---APHTLIQQTPTLH 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 152 ANWHPGEdqRPGGEDAPGPPGAGERYLPVHGLPGAHQRRPPAVQVLAA--DHLQEPRLQQPLPLPPRHAQVQVHRLPEGT 229
Cdd:pfam03154 239 PQRLPSP--HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTgpSHMQHPVPPQPFPLTPQSSQSQVPPGPSPA 316
|
....*
gi 1012734757 230 DPGDS 234
Cdd:pfam03154 317 APGQS 321
|
|
| MoxR |
COG0714 |
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ... |
494-711 |
2.78e-04 |
|
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 440478 [Multi-domain] Cd Length: 292 Bit Score: 44.00 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 494 DEESHEFVIEAGALMladNGVCCIDEFDKMDIKDQVAIHEAMEQQTISItkAGVKATLNARTSILAAANPVS--GRYDrs 571
Cdd:COG0714 80 DQQTGEFEFRPGPLF---ANVLLADEINRAPPKTQSALLEAMEERQVTI--PGGTYKLPEPFLVIATQNPIEqeGTYP-- 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 572 kslkqnvnLTAPIMSRFdLFFILVD------EcnevtdyaiaRRIVDLH-SRVEESVDRLYSLDEIRRYLLFARQFkpKI 644
Cdd:COG0714 153 --------LPEAQLDRF-LLKLYIGypdaeeE----------REILRRHtGRHLAEVEPVLSPEELLALQELVRQV--HV 211
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1012734757 645 SSESEEFIVEQYKRLRQ-RDASGGVSksawritVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLL 711
Cdd:COG0714 212 SEAVLDYIVDLVRATREhPDLRKGPS-------PRASIALLRAARALALLDGRDYVTPDDVKAVAGPV 272
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
449-588 |
1.37e-03 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 39.97 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 449 NVCIVGDPSTAKSQFLKHVEEF---SPRAVYTSGKASTAAGLTAAVVRDEESHEFVieAGALMLADN--GVCCIDEFDKM 523
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAAlsnRPVFYVQLTRDTTEEDLFGRRNIDPGGASWV--DGPLVRAARegEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012734757 524 DIKDQVAIHEAMEQQTISITKAG--VKATLNARtSILAAANPVsgryDRSKSlkqnvNLTAPIMSRF 588
Cdd:pfam07728 79 NPDVLNSLLSLLDERRLLLPDGGelVKAAPDGF-RLIATMNPL----DRGLN-----ELSPALRSRF 135
|
|
| KLF9_13_N-like |
cd21975 |
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ... |
147-251 |
6.21e-03 |
|
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.
Pssm-ID: 409240 [Multi-domain] Cd Length: 163 Bit Score: 38.52 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012734757 147 GAVLHAnwhpgedQRPGGEDAPGPPG----AGERYLPVHGLPGAHQRR---PPAVQVLAADHLQEPRLQQPLPLPPRHAQ 219
Cdd:cd21975 15 GAVVHG-------VRPDPEGAGLAAGldvrATREVAKGPGPPGPAWKPdgaDSPGLVTAAPHLLAANVLAPLRGPSVEGS 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1012734757 220 VQVHRL---------------PEGTDPGDSGGAASGVHPALSGHHPA 251
Cdd:cd21975 88 SLESGDadmgsdsdvapasgaAASTSPESSSDAASSPSPLSLLHPGE 134
|
|
| |
