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Conserved domains on  [gi|1819075505|gb|KAF3157455|]
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hypothetical protein TWF569_000036 [Orbilia oligospora]

Protein Classification

SET domain-containing protein( domain architecture ID 14448404)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 164-328 7.23e-34

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


:

Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 123.64  E-value: 7.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 164 SKGRGLIATVNIPTGTRILTESPLFTIPSppipsletsisktlNSLSkekqsayhslhnnypppssaskvktpplsgifk 243
Cdd:cd20071     8 SKGRGLVATRDIEPGELILVEKPLVSVPS--------------NSFS--------------------------------- 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 244 tnaIPCGYNSSIAGIYLTICLINHSCIPNTYHNWNENLEQeTIHAIRPINAGEEITISYISESMS-NPRRKRLQEYFGFD 322
Cdd:cd20071    41 ---LTDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNGTL-RVRALRDIKAGEELTISYIDPLLPrTERRRELLEKYGFT 116


                  ....*.
gi 1819075505 323 CQCQLC 328
Cdd:cd20071   117 CSCPRC 122
 
Name Accession Description Interval E-value
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 164-328 7.23e-34

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 123.64  E-value: 7.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 164 SKGRGLIATVNIPTGTRILTESPLFTIPSppipsletsisktlNSLSkekqsayhslhnnypppssaskvktpplsgifk 243
Cdd:cd20071     8 SKGRGLVATRDIEPGELILVEKPLVSVPS--------------NSFS--------------------------------- 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 244 tnaIPCGYNSSIAGIYLTICLINHSCIPNTYHNWNENLEQeTIHAIRPINAGEEITISYISESMS-NPRRKRLQEYFGFD 322
Cdd:cd20071    41 ---LTDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNGTL-RVRALRDIKAGEELTISYIDPLLPrTERRRELLEKYGFT 116


                  ....*.
gi 1819075505 323 CQCQLC 328
Cdd:cd20071   117 CSCPRC 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 166-302 5.55e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 65.24  E-value: 5.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 166 GRGLIATVNIPTGTRIltesplFTIPSPPIpsletsISKTLNSLSKEKQSAYHSLHNNYPPPSSASKVKTPPLSGifktn 245
Cdd:pfam00856   1 GRGLFATEDIPKGEFI------GEYVEVLL------ITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDA----- 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505 246 aiPCGYNSSIAgiyltiCLINHSCIPNTYHNWNENLEQETI--HAIRPINAGEEITISY 302
Cdd:pfam00856  64 --RALYYGNWA------RFINHSCDPNCEVRVVYVNGGPRIviFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
157-329 1.44e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 58.82  E-value: 1.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 157 FKIQTIPSKGRGLIATVNIPTGTRILTesplftIPSPPIPSletsisKTLNSLSKEKQSAY-HSLHNNypppssaskvkt 235
Cdd:COG2940     8 IEVRPSPIHGRGVFATRDIPKGTLIGE------YPGEVITW------AEAERREPHKEPLHtYLFELD------------ 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 236 pplsgifKTNAIPCGYNSSIAGiylticLINHSCIPNTYHNWNENleQETIHAIRPINAGEEITISYiSESMSNPRrkrl 315
Cdd:COG2940    64 -------DDGVIDGALGGNPAR------FINHSCDPNCEADEEDG--RIFIVALRDIAAGEELTYDY-GLDYDEEE---- 123

                         170
                  ....*....|....
gi 1819075505 316 qeyfgFDCQCQLCT 329
Cdd:COG2940   124 -----YPCRCPNCR 132
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 163-309 5.58e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 54.26  E-value: 5.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505  163 PSKGRGLIATVNIPTGTRILTESPLFtipsppIPSLETSisktlnslSKEKQSAYHSLHNNYpppssaskvktpplsgIF 242
Cdd:smart00317   9 PGKGWGVRATEDIPKGEFIGEYVGEI------ITSEEAE--------ERPKAYDTDGAKAFY----------------LF 58

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505  243 KTNAIPCGYNSSIAGIyltICLINHSCIPNTYHNWNENLEQE--TIHAIRPINAGEEITISYISESMSN 309
Cdd:smart00317  59 DIDSDLCIDARRKGNL---ARFINHSCEPNCELLFVEVNGDDriVIFALRDIKPGEELTIDYGSDYANE 124
 
Name Accession Description Interval E-value
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 164-328 7.23e-34

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 123.64  E-value: 7.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 164 SKGRGLIATVNIPTGTRILTESPLFTIPSppipsletsisktlNSLSkekqsayhslhnnypppssaskvktpplsgifk 243
Cdd:cd20071     8 SKGRGLVATRDIEPGELILVEKPLVSVPS--------------NSFS--------------------------------- 40

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 244 tnaIPCGYNSSIAGIYLTICLINHSCIPNTYHNWNENLEQeTIHAIRPINAGEEITISYISESMS-NPRRKRLQEYFGFD 322
Cdd:cd20071    41 ---LTDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNGTL-RVRALRDIKAGEELTISYIDPLLPrTERRRELLEKYGFT 116


                  ....*.
gi 1819075505 323 CQCQLC 328
Cdd:cd20071   117 CSCPRC 122
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 163-329 1.79e-17

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 80.87  E-value: 1.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 163 PSKGRGLIATVNIPTGTRILTESPLFTIPSPPIPSLEtSISKTLNSL------SKEKQSAYHSLHNNYPPPSSASKV--- 233
Cdd:cd19203     9 AEKGRGLRAVTPLKPGELVLKADPFAYTVCNPPDSVR-LEGRIIFKLldkapsESEKLYSFYDLQSNINKLSEDRKEglr 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 234 ------------------KTPPLSGIFKTNA-IPCgyNS-SIA---------GIYLTICLINHSCIPNTYHNWN-ENLEq 283
Cdd:cd19203    88 qlamvlqhylreeiqdasQLPPAFDIFELFAkVTC--NSfTICdaemqevgvGLYPSASLLNHSCDPNCVIVFNgPHLL- 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1819075505 284 etIHAIRPINAGEEITISYISE-SMSNPRRKRLQEYFGFDCQCQLCT 329
Cdd:cd19203   165 --LRAIREIEVGEELTISYIDMlMPSEERRKQLRDQYCFECDCFRCQ 209
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 163-328 6.62e-17

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 79.65  E-value: 6.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 163 PSKGRGLIATVNIPTGTRILTE----SPLFTIPSP--PIPSLETSISKTlnSLSKEKQSA------YHSL---------- 220
Cdd:cd10536    14 EEKGRFLVATRDIKAGEVLIVEkpyaSVLLPYSSDyrSVYNLVTHTENR--SPEDLFQRAltavflAKCLqlsgyfllwe 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 221 -HNNYPPPSSASKVKTPPLS--GIFKTNAIP---CGYNSS-----------IA-GIYLTICLINHSCIPNTYHNWNENle 282
Cdd:cd10536    92 aSTELNGEEPESILGGLLLRhlQQLQCNAHAiteLQTTSSgsqvdtskqvrIAtAIYPTLSLLNHSCDPNTIRSFYGN-- 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1819075505 283 QETIHAIRPINAGEEITISY--------ISEsmsnpRRKRLQEYFGFDCQCQLC 328
Cdd:cd10536   170 TIVVRATRPIKKGEEITICYgphfsrmkRSE-----RQRLLKEQYFFDCSCEAC 218
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 163-330 9.87e-16

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 75.92  E-value: 9.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 163 PSKGRGLIATVNIPTGTRILTESPLFTIPSPPIPSLETSISKT--------------------------LNSLSKEKQSA 216
Cdd:cd10526     9 EGKGRGLKATKEFWAGDVIFAEPPYAAVVFGKAPNENIRLAARilwriereggglkegelvsiedlqdhLEDFSEEEKKD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 217 Y----HSLHNNYPPPSSASKVKT-PPLSGIFKTNAIPC----GYNSSIAGIYLTICLINHSCIPN-TYHNWNENLEqetI 286
Cdd:cd10526    89 LredvHSFLDYWPYQSQQFSMEYiSHIFGVINCNGFTLsdqrGLQAVGVGIFPNLCLVNHDCWPNcTVIFNNGRIE---L 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1819075505 287 HAIRPINAGEEITISYI-SESMSNPRRKRLQEYFGFDCQCQLCTS 330
Cdd:cd10526   166 RALGKISEGDELTVSYIdFLNTSEDRKEQLKKQYYFDCTCEHCTK 210
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 163-329 1.53e-15

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 75.16  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 163 PSKGRGLIATVNIPTGTRILTESPLFTIPSPP--------------------------IPSLETSISKTLNSLSKEKQSA 216
Cdd:cd19167     9 PGKGRGLRALKPFEPGDLIFSERPYAYVLTPPehvrltgrilykqhirktrtsgkllsVYDLESHVEKLDEEKKDGLRSD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 217 YHSLHNNYPPpssasKVKTPPLSGIFKTNA-IPC-GYN------SSIA-GIYLTICLINHSCIPNTYHNWN-ENLEqetI 286
Cdd:cd19167    89 VATLHQFMSK-----DLQLPDAAYLVELFGkVNCnGFTisdeelQHVGvGIYPQAALLNHSCCPNCIVTFNgPNIE---V 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1819075505 287 HAIRPINAGEEITISYISESM-SNPRRKRLQEYFGFDCQCQLCT 329
Cdd:cd19167   161 RAVQEIEPGEEVFHSYIDLLYpTEERRDQLRDQYFFLCQCADCQ 204
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 166-302 5.55e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 65.24  E-value: 5.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 166 GRGLIATVNIPTGTRIltesplFTIPSPPIpsletsISKTLNSLSKEKQSAYHSLHNNYPPPSSASKVKTPPLSGifktn 245
Cdd:pfam00856   1 GRGLFATEDIPKGEFI------GEYVEVLL------ITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDA----- 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505 246 aiPCGYNSSIAgiyltiCLINHSCIPNTYHNWNENLEQETI--HAIRPINAGEEITISY 302
Cdd:pfam00856  64 --RALYYGNWA------RFINHSCDPNCEVRVVYVNGGPRIviFALRDIKPGEELTIDY 114
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 256-330 4.12e-12

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 66.56  E-value: 4.12e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505 256 AGIYLTICLINHSCIPNTYHNWNENLEQETIHAIRPINAGEEITISYISESMSN----PRRKRLQEYFGFDCQCQLCTS 330
Cdd:cd10521   203 SGLYLLQSCCNHSCVPNAEITFPENNFTLSLKALRDIQEGEEICISYLDECQRErsrhSRQKILRENYLFICNCPKCEA 281
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
157-329 1.44e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 58.82  E-value: 1.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 157 FKIQTIPSKGRGLIATVNIPTGTRILTesplftIPSPPIPSletsisKTLNSLSKEKQSAY-HSLHNNypppssaskvkt 235
Cdd:COG2940     8 IEVRPSPIHGRGVFATRDIPKGTLIGE------YPGEVITW------AEAERREPHKEPLHtYLFELD------------ 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 236 pplsgifKTNAIPCGYNSSIAGiylticLINHSCIPNTYHNWNENleQETIHAIRPINAGEEITISYiSESMSNPRrkrl 315
Cdd:COG2940    64 -------DDGVIDGALGGNPAR------FINHSCDPNCEADEEDG--RIFIVALRDIAAGEELTYDY-GLDYDEEE---- 123

                         170
                  ....*....|....
gi 1819075505 316 qeyfgFDCQCQLCT 329
Cdd:COG2940   124 -----YPCRCPNCR 132
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 163-309 5.58e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 54.26  E-value: 5.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505  163 PSKGRGLIATVNIPTGTRILTESPLFtipsppIPSLETSisktlnslSKEKQSAYHSLHNNYpppssaskvktpplsgIF 242
Cdd:smart00317   9 PGKGWGVRATEDIPKGEFIGEYVGEI------ITSEEAE--------ERPKAYDTDGAKAFY----------------LF 58

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505  243 KTNAIPCGYNSSIAGIyltICLINHSCIPNTYHNWNENLEQE--TIHAIRPINAGEEITISYISESMSN 309
Cdd:smart00317  59 DIDSDLCIDARRKGNL---ARFINHSCEPNCELLFVEVNGDDriVIFALRDIKPGEELTIDYGSDYANE 124
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 157-302 6.16e-09

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 53.80  E-value: 6.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1819075505 157 FKIQTIPSKGRGLIATVNIPTGTRIlTESPLFTIPSppipsletsisktlnslsKEKQSAYHSLHNNYpppssaskvktp 236
Cdd:cd10540     2 LEVKPSTLKGRGVFATRPIKKGEVI-EEAPVIVLPK------------------EEYQHLCKTVLDHY------------ 50

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1819075505 237 plsgIF----KTNAIPCGYNSsiagiylticLINHSCIPNTYhnWNENLEQETI--HAIRPINAGEEITISY 302
Cdd:cd10540    51 ----VFswgdGCLALALGYGS----------MFNHSYTPNAE--YEIDFENQTIvfYALRDIEAGEELTINY 106
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 240-302 6.61e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 49.56  E-value: 6.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1819075505 240 GIFKTNAIPcgynssiAGIYLTIC-LINHSCIPNTYHNWNENLEQET--IHAIRPINAGEEITISY 302
Cdd:cd08161    13 GLFATRDIP-------KGEVIGLArFINHSCEPNCEFEEVYVGGKPRvfIVALRDIKAGEELTVDY 71
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 256-330 2.80e-07

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 50.98  E-value: 2.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1819075505 256 AGIYLTICLINHSCIPNTYHNWNENLEQetIHAIRPINAGEEITISYISESM-SNPRRKRLQEYFGFDCQCQLCTS 330
Cdd:cd19202   133 SAIFPDVALMNHSCCPNVIVTYKGTLAE--VRAVQEIKPGEEVFTSYIDLLYpTEDRNDRLRDSYFFTCECQECTT 206
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 264-328 4.47e-07

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 49.20  E-value: 4.47e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505 264 LINHSCIPNTyhNWNENLEQET-IHAIRPINAGEEITISYiSEsmsnprrkrlqEYFGF---DCQCQLC 328
Cdd:cd10524    79 FINHDCRPNC--KFVPTGKSTAcVKVLRDIEPGEEITVYY-GD-----------NYFGEnneECECETC 133
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 265-325 2.10e-06

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 47.25  E-value: 2.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1819075505 265 INHSCIPNTY-HNWNENLE-QETIHAIRPINAGEEITISYISESMSNPrrkrlqeyfGFDCQC 325
Cdd:cd10531    77 INHSCEPNCEtQKWIVNGEyRIGIFALRDIPAGEELTFDYNFVNYNEA---------KQVCLC 130
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 265-302 2.87e-05

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 43.94  E-value: 2.87e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1819075505 265 INHSCIPNT-YHNWNENLEQET-IHAIRPINAGEEITISY 302
Cdd:cd19175    77 INHSCDPNCeLQKWQVDGETRIgVFAIRDIKKGEELTYDY 116
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 264-321 5.55e-05

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 44.36  E-value: 5.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1819075505 264 LINHS-CIPNTYHNWNENLEQETIHAIRPINAGEEITISYisESMSNPrrkRLQEYFGF 321
Cdd:cd10527   182 MLNHSpDAPNVRYEYDEDEGSFVLVATRDIAAGEEVFISY--GPKSND---ELLLYYGF 235
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 265-325 1.03e-04

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 43.82  E-value: 1.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1819075505 265 INHSCIPN--TYHNWNENLEqETIH-----AIRPINAGEEITISYI------SESMSNPRRKRlqeyFGFDCQC 325
Cdd:cd10542   168 INHSCDPNlaVYAVWINHLD-PRLPriaffAKRDIKAGEELTFDYLmtgtggSSESTIPKPKD----VRVPCLC 236
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 265-302 2.67e-04

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 41.17  E-value: 2.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1819075505 265 INHSCIPNTYHN--WNENLEQETIHAIRPINAGEEITISY 302
Cdd:cd19169    90 INHSCNPNCYAKiiTVESQKKIVIYSKRPIAVNEEITYDY 129
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 265-302 1.21e-03

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 39.10  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1819075505 265 INHSCIPNTY-HNWNENLEQET-IHAIRPINAGEEITISY 302
Cdd:cd19172    79 INHSCEPNCEtQKWTVNGELRVgFFAKRDIPAGEELTFDY 118
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 264-302 9.59e-03

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 36.50  E-value: 9.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1819075505 264 LINHSCIPNTY-HNWNEN-LEQETIHAIRPINAGEEITISY 302
Cdd:cd19174    75 FVNHSCDPNCEmQKWSVNgVYRIGLFALKDIPAGEELTYDY 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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